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5. Development, multi-institutional external validation, and algorithmic audit of an artificial intelligence-based Side-specific Extra-Prostatic Extension Risk Assessment tool (SEPERA) for patients undergoing radical prostatectomy: a retrospective cohort study

Author

Kwong, Jethro C C, Khondker, Adree, Meng, Eric, Taylor, Nicholas, Kuk, Cynthia, Perlis, Nathan, Kulkarni, Girish S, Hamilton, Robert J, Fleshner, Neil E, Finelli, Antonio, van der Kwast, Theodorus H, Ali, Amna, Jamal, Munir, Papanikolaou, Frank, Short, Thomas, Srigley, John R, Colinet, Valentin, Peltier, Alexandre, Diamand, Romain, Lefebvre, Yolene, Mandoorah, Qusay, Sanchez-Salas, Rafael, Macek, Petr, Cathelineau, Xavier, Eklund, Martin, Johnson, Alistair E W, Feifer, Andrew, and Zlotta, Alexandre R

Published
2023
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8. MP68-07 PROPORTION OF GLEASON 8-10 PROSTATE CANCER FOUND ON BIOPSY AND TUMOR AGGRESSIVENESS IN MATCHED COHORTS OF MEN IN ASIA AND WESTERN COUNTRIES

Author

Dong, Liang, primary, Lajkosz, Katherine, additional, Sanchez-Salas, Rafael, additional, Tiwari, Raj Vikesh, additional, Dias dos Santos, Caio Pasquali, additional, Dong, Baijun, additional, Pan, Jiahua, additional, Chan, Amy, additional, Woon, Dixon, additional, Kulkarni, Girish S., additional, Perlis, Nathan, additional, Hamilton, Rob, additional, Klotz, Laurence, additional, Wallis, Christopher J. D., additional, Macek, Petr, additional, Kae, Jack Tay, additional, Toi, Ants, additional, Finelli, Antonio, additional, Fleshner, Neil E., additional, Cathelineau, Xavier, additional, van der Kwast, Theodorus H., additional, Xue, Wei, additional, and Zlotta, Alexandre R., additional

Published
2024
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10. PD19-04 IMPACT OF NOVEL PATIENT-CENTERED PATHOLOGY REPORTS ON MEN UNDERGOING PROSTATE BIOPSY: THE PAPR RANDOMIZED CONTROLLED TRIAL

Author

Kumar, Ravi M, primary, Lajkosz, Katherine, additional, Silberman, Amalia, additional, Finelli, Antonio, additional, Fleshner, Neil, additional, Hamilton, Robert, additional, Kulkarni, Girish, additional, Zlotta, Alexandre, additional, Berlin, Alejandro, additional, Papadakos, Janet, additional, Ghai, Sangeet, additional, Deniffel, Dominik, additional, Wiljer, David, additional, Alibhai, Shabbir, additional, Cafazzo, Joseph, additional, Haider, Masoom, additional, Lee, Odelia, additional, Calicchia, Lauren, additional, Janusonis, Isabella, additional, Lovas, Mike, additional, Kreidstein, Jayson, additional, Hiemstra, Jenna, additional, and Perlis, Nathan, additional

Published
2024
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11. PD27-10 TEMPORAL VALIDATION OF AN ARTIFICIAL INTELLIGENCE TOOL (SEPERA) TO INFORM NERVE-SPARING STRATEGY DURING RADICAL PROSTATECTOMY AND COMPARISON AGAINST UROLOGISTS

Author

Pickel, Lauren, primary, Zhang, Kevin, additional, Booth, Ryan, additional, Shahid, Aiman, additional, Ringa, Maximiliano, additional, Ali, Amna, additional, Chan, Amy, additional, Perlis, Nathan, additional, Hamilton, Robert J., additional, Fleshner, Neil E., additional, Finelli, Antonio, additional, Johnson, Alistair E. W., additional, Kulkarni, Girish S., additional, Feifer, Andrew, additional, Zlotta, Alexandre R., additional, and Kwong, Jethro C. C., additional

Published
2024
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13. Extended Results and Independent Validation of a Phase 2 Trial of Metastasis-Directed Therapy for Molecularly Defined Oligometastatic Prostate Cancer

Author

Glicksman, Rachel M., Ramotar, Matthew, Metser, Ur, Chung, Peter W., Liu, Zhihui, Vines, Douglass, Finelli, Antonio, Hamilton, Robert, Fleshner, Neil E., Perlis, Nathan, Zlotta, Alexandre R., Bayley, Andrew, Helou, Joelle, Raman, Srinivas, Kulkarni, Girish, Catton, Charles, Lam, Tony, Chan, Rosanna, Warde, Padraig, Gospodarowicz, Mary, Jaffray, David A., and Berlin, Alejandro

Published
2022
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14. A novel predictor of clinical progression in patients on active surveillance for prostate cancer

Author

Tan, Guan Hee, Finelli, Antonio, Ahmad, Ardalan, Wettstein, Marian S, Chandrasekar, Thenappan, Zlotta, Alexandre R, Fleshner, Neil E, Hamilton, Robert J, Kulkarni, Girish S, Ajib, Khaled, Nason, Gregory, and Perlis, Nathan

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Brain Disorders, Prevention, Cancer, Urologic Diseases, Aging, Clinical Research, Patient Safety, Prostate Cancer, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Urology & Nephrology, Clinical sciences, Oncology and carcinogenesis
Abstract

IntroductionActive surveillance (AS) is standard of care in low-risk prostate cancer (PCa). This study describes a novel total cancer location (TCLo) density metric and aims to determine its performance in predicting clinical progression (CP) and grade progression (GP).MethodsThis was a retrospective study of patients on AS after confirmatory biopsy (CBx). We excluded patients with Gleason ≥7 at CBx and 0.05) was independently associated with time to CP (hazard ratio [HR] 4.70; 95% confidence interval [CI] 2.62-8.42; p

Published
2019

15. “Bring the Hoses to Where the Fire Is!”: Differential Impacts of Marginalization and Socioeconomic Status on COVID-19 Case Counts and Healthcare Costs

Author

Cheung, Douglas C., Bremner, Karen E., Tsui, Teresa C.O., Croxford, Ruth, Lapointe-Shaw, Lauren, Giudice, Lisa Del, Mendlowitz, Andrew, Perlis, Nathan, Pataky, Reka E., Teckle, Paulos, Zeitouny, Seraphine, Wong, William W.L., Sander, Beate, Peacock, Stuart, Krahn, Murray D., Kulkarni, Girish S., and Mulder, Carol

Published
2022
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17. Replacing surveillance cystoscopy with urinary biomarkers in followup of patients with non-muscle-invasive bladder cancer: Patients’ and urologic oncologists’ perspectives

Author

Sayyid, Rashid K, Sayyid, Abdallah K, Klaassen, Zachary, Hersey, Karen, Goldberg, Hanan, Perlis, Nathan, Ahmad, Ardalanejaz, Leao, Ricardo, Chandrasekar, Thenappan, Fadaak, Kamel, Madi, Rabii, Terris, Martha K, Finelli, Antonio, Hamilton, Robert J, Kulkarni, Girish S, Zlotta, Alexandre R, and Fleshner, Neil E

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Urologic Diseases, Cancer, Clinical Research, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, Clinical Sciences, Urology & Nephrology, Clinical sciences, Oncology and carcinogenesis
Abstract

INTRODUCTION:Urinary biomarkers are being developed to detect bladder cancer recurrence/progression in patients with non-muscle-invasive bladder cancer (NMIBC). We conducted a questionnaire-based study to determine what diagnostic accuracy and cost would such test(s) need for both patients and urologic oncologists to comfortably forgo surveillance cystoscopy in favour of these tests. METHODS:Surveys were administered to NMIBC patients at followup cystoscopy visit and to physician members of the Society of Urologic Oncology. Participants were questioned about acceptable false-negative (FN) rates and costs for such alternatives, in addition to demographics that could influence chosen error rates and costs. RESULTS:A total of 137 patient and 51 urologic oncologist responses were obtained. Seventy-seven percent of patients were not comfortable with urinary biomarker(s) alternatives to repeat cystoscopy, with a further 14% willing to accept such alternatives only if the FN rate were 0.5% or lower. Seventy-five percent of urologic oncologists were comfortable with an alternative urinary biomarker test(s), with 37% and 33% willing to accept FN rates of 5% and 1%, respectively. Forty-seven percent of patients were not willing to pay out-of-pocket for such tests, while 61% of urologic oncologists felt that a price range of $100-500 would be reasonable. CONCLUSIONS:This is the first survey evaluating patient and urologic oncologist perspectives on acceptable error rates and costs for urinary biomarker alternatives to surveillance cystoscopy for patients with NMIBC. Despite potential responder bias, this study suggests that urinary biomarker(s) will require sensitivity equivalent to that of cystoscopy in order to completely replace it in surveillance of patients with NMIBC.

Published
2018

18. MRI-guided Focused Ultrasound Focal Therapy for Intermediate-Risk Prostate Cancer: Final Results from a 2-year Phase II Clinical Trial

Author

Ghai, Sangeet, primary, Finelli, Antonio, additional, Corr, Kateri, additional, Lajkosz, Katherine, additional, McCluskey, Stuart, additional, Chan, Rosanna, additional, Gertner, Mark, additional, van der Kwast, Theodorus H., additional, Incze, Peter F., additional, Zlotta, Alexandre R., additional, Kucharczyk, Walter, additional, and Perlis, Nathan, additional

Published
2024
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19. DEVELOPMENT AND EXTERNAL VALIDATION OF NIMBLE, AN ARTIFICIAL INTELLIGENCE-BASED TOOL TO PREDICT PROGRESSION IN NON-MUSCLE INVASIVE BLADDER CANCER: A RETROSPECTIVE MULTI-INSTITUTIONAL COHORT STUDY

Author

Kwong, Jethro C.C., primary, Al-Daqqaq, Zizo, additional, Chelliahpillai, Yashan, additional, Lee, Soomin, additional, Kim, Kellie, additional, Chan, Amy, additional, Kuk, Cynthia, additional, Zlotta, Alexandre R., additional, Ringa, Maximiliano, additional, Ali, Amna, additional, Feifer, Andrew, additional, Perlis, Nathan, additional, Lee, Jason Y., additional, Hamilton, Robert J., additional, Fleshner, Neil E., additional, Finelli, Antonio, additional, Kulkarni, Girish S., additional, and Johnson, Alistair E.W., additional

Published
2024
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25. Extraprostatic Extension in Core Biopsies Epitomizes High-risk but Locally Treatable Prostate Cancer

Author

Goldberg, Hanan, Ramiz, Abu-Hijlih, Glicksman, Rachel, Salgado, Noelia S., Chandrasekar, Thenappan, Klaassen, Zachary, Wallis, Christopher J.D., Hosni, Ali, Moraes, Fabio Ynoe, Ghai, Sangeet, Kulkarni, Girish S., Hamilton, Robert J., Perlis, Nathan, Toi, Ants, Chung, Peter, Evans, Andrew, van der Kwast, Theo, Finelli, Antonio, Fleshner, Neil, and Berlin, Alejandro

Published
2019
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27. Stockholm3 validation in a multi-ethnic cohort for prostate cancer (SEPTA) detection: A multicentered, prospective trial.

Author

Vigneswaran, Hari Thambiah, Eklund, Martin, Discacciati, Andrea, Nordström, Tobias, Hubbard, Rebecca A., Perlis, Nathan, Abern, Michael, Moreira, Daniel, Eggener, Scott E., Yonover, Paul M., Chow, Alexander, Watts, Kara, Liss, Michael A., Thoreson, Gregory R, Abreu, Andre Luis, Sonn, Geoffrey A, Palsdottir, Thorgerdur, Wiklund, Fredrik, Gronberg, Henrik, and Murphy, Adam B

Published
2024
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28. A Systematic Review and Meta-Analysis of the Cancer-Related and Functional Outcomes of High-Intensity Focused Ultrasound, Open Radical Prostatectomy, Robot Assisted Radical Prostatectomy, and External Beam Radiation Therapy in Primary Treatment of Localized Low- or Intermediate-Risk Prostate Cancer

Author

Toeama, Bassem, Papadimitropoulos, Emmanuel, Perlis, Nathan, Grootendorst, Paul, and Hamandi, Bassem

Subjects
CAUSES of death, MEDICAL databases, META-analysis, IMPOTENCE, MEDICAL information storage & retrieval systems, FUNCTIONAL status, RADICAL prostatectomy, SURGICAL robots, SYSTEMATIC reviews, CASE-control method, PRIMARY health care, TREATMENT effectiveness, RANDOMIZED controlled trials, URINARY incontinence, DESCRIPTIVE statistics, ULTRASONIC therapy, RADIOTHERAPY, PROGRESSION-free survival, MEDLINE, ABLATION techniques, PROSTATE tumors, DISEASE risk factors
Abstract

Objective: Prostate cancer is the second-leading cause of cancer death among men. We aimed to evaluate high-intensity focused ultrasound (HIFU), open radical prostatectomy (ORP), robot-assisted radical prostatectomy (RARP), and external beam radiation therapy (RT) in the treatment of localized low- and intermediate-risk prostate cancer. Methods: We searched bibliographic databases for case-control, cohort, and randomized controlled studies. We used MeSH subject headings and free text terms for prostate cancer, HIFU, ORP, RARP, RT, failure-free survival (FFS), biochemical disease-free survival (BDFS), urinary incontinence (UI), and erectile dysfunction (ED). Results: Fourteen studies were included in the review, for a total of 34 927 participants. Among the 8 studies of HIFU as the primary treatment of localized low- and intermediate-risk prostate cancer, 4 studies reported 5-year FFS rates ranging from 67.8% to 97.8%, 3 studies reported 5-year BDFS ranging from 58% to 85.4%, 5 studies reported 1-year UI rates ranging from 0% to 6%, and 4 studies reported 1-year ED rates ranging from 11.4% to 38.7%. Furthermore, our search revealed a 5-year FFS benefit favoring ORP compared to RT, a 1-year UI rate favoring ORP compared to RARP, and a 1-year ED rate favoring ORP compared to RARP. Conclusion: Our systematic review and meta-analysis revealed lack of studies with active comparators comparing HIFU to standard of care (ORP, RARP, or RT) in primary treatment of localized low- and intermediate-risk prostate cancer. Open radical prostatectomy has favorable efficacy outcomes compared to RT, while RARP has beneficial functional outcomes compared to ORP, respectively. [ABSTRACT FROM AUTHOR]

Published
2024
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29. The impact of the early COVID-19 pandemic on healthcare system resource use and costs in two provinces in Canada: An interrupted time series analysis

Author

Zeitouny, Seraphine, primary, Cheung, Douglas C., additional, Bremner, Karen E., additional, Pataky, Reka E., additional, Pequeno, Priscila, additional, Matelski, John, additional, Peacock, Stuart, additional, Del Giudice, M. Elisabeth, additional, Lapointe-Shaw, Lauren, additional, Tomlinson, George, additional, Mendlowitz, Andrew B., additional, Mulder, Carol, additional, Tsui, Teresa C. O., additional, Perlis, Nathan, additional, Walker, Jennifer D., additional, Sander, Beate, additional, Wong, William W. L., additional, Krahn, Murray D., additional, and Kulkarni, Girish S., additional

Published
2023
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38. MP61-02 DEVELOPMENT, MULTI-INSTITUTIONAL EXTERNAL VALIDATION, AND ALGORITHMIC AUDIT OF SEPERA - AN ARTIFICIAL INTELLIGENCE-BASED SIDE-SPECIFIC EXTRA-PROSTATIC EXTENSION RISK ASSESSMENT TOOL FOR PATIENTS UNDERGOING RADICAL PROSTATECTOMY

Author

Kwong, Jethro, primary, Khondker, Adree, additional, Meng, Eric, additional, Taylor, Nicholas, additional, Kuk, Cynthia, additional, Perlis, Nathan, additional, Kulkarni, Girish, additional, Hamilton, Robert, additional, Fleshner, Neil, additional, Finelli, Antonio, additional, Kwast, Theodorus Van Der, additional, Ali, Amna, additional, Jamal, Munir, additional, Papanikolaou, Frank, additional, Short, Thomas, additional, Srigley, John, additional, Colinet, Valentin, additional, Peltier, Alexandre, additional, Diamand, Romain, additional, Lefebvre, Yolene, additional, Mandoorah, Qusay, additional, Sanchez-Salas, Rafael, additional, Macek, Petr, additional, Cathelineau, Xavier, additional, Eklund, Martin, additional, Johnson, Alistair, additional, Feifer, Andrew, additional, and Zlotta, Alexandre, additional

Published
2023
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41. Validating the total cancer location density metric for stratifying patients with low-risk localized prostate cancer at higher risk of grade group reclassification while on active surveillance

Author

Tan, Guan Hee, primary, Deniffel, Dominik, additional, Finelli, Antonio, additional, Wettstein, Marian, additional, Ahmad, Ardalan, additional, Zlotta, Alexandre, additional, Fleshner, Neil, additional, Hamilton, Robert, additional, Kulkarni, Girish, additional, Nason, Gregory, additional, Ajib, Khaled, additional, Herrera-Caceres, Jaime, additional, Chandrasekar, Thenappan, additional, and Perlis, Nathan, additional

Published
2023
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44. Comparison of Micro-US and Multiparametric MRI for Prostate Cancer Detection in Biopsy-Naive Men

Author

Ghai, Sangeet, primary, Perlis, Nathan, additional, Atallah, Chantal, additional, Jokhu, Sarah, additional, Corr, Kateri, additional, Lajkosz, Katherine, additional, Incze, Peter F., additional, Zlotta, Alexandre R., additional, Jain, Umesh, additional, Fleming, Hannah, additional, Finelli, Antonio, additional, van der Kwast, Theodorus H., additional, and Haider, Masoom A., additional

Published
2022
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48. Initial health care costs for COVID-19 in British Columbia and Ontario, Canada: an interprovincial population-based cohort study

Author

Tsui, Teresa C.O., primary, Zeitouny, Seraphine, additional, Bremner, Karen E., additional, Cheung, Douglas C., additional, Mulder, Carol, additional, Croxford, Ruth, additional, Del Giudice, Lisa, additional, Lapointe-Shaw, Lauren, additional, Mendlowitz, Andrew, additional, Wong, William W.L., additional, Perlis, Nathan, additional, Sander, Beate, additional, Teckle, Paulos, additional, Tomlinson, George, additional, Walker, Jennifer D., additional, Malikov, Kamil, additional, McGrail, Kimberlyn M., additional, Peacock, Stuart, additional, Kulkarni, Girish S., additional, Pataky, Reka E., additional, and Krahn, Murray D., additional

Published
2022
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50. Testosterone Responders to Continuous Androgen Deprivation Therapy Show Considerable Variations in Testosterone Levels on Followup: Implications for Clinical Practice

Author

Sayyid, Rashid K., Sayyid, Abdallah K., Klaassen, Zachary, Fadaak, Kamel, Goldberg, Hanan, Chandrasekar, Thenappan, Ahmad, Ardalanejaz, Leao, Ricardo, Perlis, Nathan, Chadwick, Karen, Hamilton, Robert J., Kulkarni, Girish S., Finelli, Antonio, Zlotta, Alexandre R., and Fleshner, Neil E.

Published
2018
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