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Your search keyword '"Perissoud, D."' showing total 3 results
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3 results on '"Perissoud, D."'

1. Novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors

Author

Fehrentz, Jean-Alain, Moulin, Aline, Martinez, Jean, Demange, Luc, Boeglin, D. B. D., Perissoud, D., Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), and Aeterna-Zentaris

Subjects
[CHIM.ORGA]Chemical Sciences/Organic chemistry, hormones, hormone substitutes, and hormone antagonists
Abstract

The present invention provides novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors according to formula (I) that are useful in the treatment or prophylaxis of physiological and/or pathophysiological conditions in mammals, preferably humans, that are mediated by GHS receptors. The present invention further provides GHS receptor antagonists and agonists that can be used for modulation of these receptors and are useful for treating above conditions, in particular growth retardation, cachexia, short-, medium- and/or long term regulation of energy balance; short-, medium- and/or long term regulation (stimulation and/or inhibition) of food intake; adipogenesis, adiposity and/or obesity; body weight gain and/or reduction; diabetes, diabetes type I, diabetes type II, tumor cell proliferation; inflammation, inflammatory effects, gastric postoperative ileus, postoperative ileus and/or gastrectomy (ghrelin replacement therapy).

Published
2008

2. New series of Ghrelin Receptor Ligands : Structure Activity Relationship Study on the triazole Moiety

Author

Moulin, Aline, Demange, L., Ryan, Joanne, Perissoud, D., Gagne, Didier, Bergé, Gilbert, Galleyrand, Jean-Claude, Martinez, Jean, Fehrentz, Jean-Alain, Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), and Zentaris GmbH

Subjects
[CHIM.ORGA]Chemical Sciences/Organic chemistry
Published
2007

3. Flavonoids and hepatic cyclic monophosphates in liver injury.

Author

Scevola D, Barbarini G, Grosso A, Bona S, and Perissoud D

Subjects
Animals, Bilirubin metabolism, Catechin analogs & derivatives, Hepatitis, Animal chemically induced, Liver drug effects, Male, Models, Biological, Rats, Rats, Inbred Strains, Benzopyrans pharmacology, Catechin pharmacology, Cyclic AMP metabolism, Cyclic GMP metabolism, Hepatitis, Animal metabolism, Liver metabolism
Abstract

Among the large spectrum of pharmacological activities of flavonoids, play an important role the recently investigated properties involving the arachidonic acid metabolism. In order to clarify the mechanisms of "cytoprotection" of the 3-palmitoyl-(+)-catechin (Palm-cat), a new flavonoid compound (C31 H44 O7) we have studied in experimental hepatitis of the rat, induced by Galactosamine (Ga1N) and E. coli 055:B 5 endotoxin (LPS), hepatic cAMP and cGMP, transaminases, bilirubin and endotoxemia. The Palm-cat significantly increases cyclic-GMP levels in the liver, whereas reduces or slightly modifies the cAMP. Transaminases and bilirubin values increase both in controls and flavonoid treated rats. The flavonoid significantly decreases the frequency of endotoxemia. These effects suggest that RES and hepatocytes functions, immune and inflammatory response can be affected in liver disease by flavonoids via cyclic nucleotides regulation.

Published
1984

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