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452 results on '"Perini, Giovanni"'

1. The transcriptional co-repressor Runx1t1 is essential for MYCN-driven neuroblastoma tumorigenesis

Author

Murray, Jayne E., Valli, Emanuele, Milazzo, Giorgio, Mayoh, Chelsea, Gifford, Andrew J., Fletcher, Jamie I., Xue, Chengyuan, Jayatilleke, Nisitha, Salehzadeh, Firoozeh, Gamble, Laura D., Rouaen, Jourdin R. C., Carter, Daniel R., Forgham, Helen, Sekyere, Eric O., Keating, Joanna, Eden, Georgina, Allan, Sophie, Alfred, Stephanie, Kusuma, Frances K., Clark, Ashleigh, Webber, Hannah, Russell, Amanda J., de Weck, Antoine, Kile, Benjamin T., Santulli, Martina, De Rosa, Piergiuseppe, Fleuren, Emmy D. G., Gao, Weiman, Wilkinson-White, Lorna, Low, Jason K. K., Mackay, Joel P., Marshall, Glenn M., Hilton, Douglas J., Giorgi, Federico M., Koster, Jan, Perini, Giovanni, Haber, Michelle, and Norris, Murray D.

Published
2024
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2. PainPoints: A Framework for Language-based Detection of Chronic Pain and Expert-Collaborative Text-Summarization

Author

Fadnavis, Shreyas, Dhurandhar, Amit, Norel, Raquel, Reinen, Jenna M, Agurto, Carla, Secchettin, Erica, Schweiger, Vittorio, Perini, Giovanni, and Cecchi, Guillermo

Subjects
Computer Science - Computation and Language, Computer Science - Artificial Intelligence, Computer Science - Machine Learning
Abstract

Chronic pain is a pervasive disorder which is often very disabling and is associated with comorbidities such as depression and anxiety. Neuropathic Pain (NP) is a common sub-type which is often caused due to nerve damage and has a known pathophysiology. Another common sub-type is Fibromyalgia (FM) which is described as musculoskeletal, diffuse pain that is widespread through the body. The pathophysiology of FM is poorly understood, making it very hard to diagnose. Standard medications and treatments for FM and NP differ from one another and if misdiagnosed it can cause an increase in symptom severity. To overcome this difficulty, we propose a novel framework, PainPoints, which accurately detects the sub-type of pain and generates clinical notes via summarizing the patient interviews. Specifically, PainPoints makes use of large language models to perform sentence-level classification of the text obtained from interviews of FM and NP patients with a reliable AUC of 0.83. Using a sufficiency-based interpretability approach, we explain how the fine-tuned model accurately picks up on the nuances that patients use to describe their pain. Finally, we generate summaries of these interviews via expert interventions by introducing a novel facet-based approach. PainPoints thus enables practitioners to add/drop facets and generate a custom summary based on the notion of "facet-coverage" which is also introduced in this work.

Published
2022

3. MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma

Author

Tao, Ling, Mohammad, Mahmoud A., Milazzo, Giorgio, Moreno-Smith, Myrthala, Patel, Tajhal D., Zorman, Barry, Badachhape, Andrew, Hernandez, Blanca E., Wolf, Amber B., Zeng, Zihua, Foster, Jennifer H., Aloisi, Sara, Sumazin, Pavel, Zu, Youli, Hicks, John, Ghaghada, Ketan B., Putluri, Nagireddy, Perini, Giovanni, Coarfa, Cristian, and Barbieri, Eveline

Published
2022
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4. EBV Type II latency relies on PARP1 activity and is essential for gastric epithelial cell transformation in EBV-associated Gastric Cancer (EBVaGC)

Author

Perini, Giovanni, Maestri, Davide <1995>, Perini, Giovanni, and Maestri, Davide <1995>

Abstract

Epstein-Barr virus (EBV) establishes a lifelong asymptomatic infection by replicating its chromatinized genome, called episome, together with the host genome. EBV exhibits different latency-associated transcriptional repertoires that mirror its three-dimensional structures of the genome. CTCF, Cohesin and PARP1 are involved in maintaining viral latency and establishing episome architecture. Epstein-Barr virus-associated gastric cancer (EBVaGC) represents almost 10% of all gastric cancers globally. EBVaGC exhibit an intermediate viral transcription profile known as "Latency II", expressing specific viral genes and non-coding RNAs. In this study, we investigated the impact of PARP1 inhibition on CTCF/Cohesin binding in Type II latency. We observed a destabilization of the binding of both factors, leading to a disrupted three-dimensional architecture of the episomes and consequently, an altered viral gene expression. Despite sharing the same CTCF binding profile, Type I, II, and III latencies display different 3D episomal structures that correlate with variations in viral gene expression. Additionally, our analysis of H3K27ac-enriched chromatin interactions revealed differences between Type II latency episomes and a link to cellular transformation through docking of the EBV episomes at specific sites of the Human genome, thus promoting oncogene expression. Overall, this work provides insights into the role of PARP1 in maintaining active latency and novel mechanisms of EBV-induced cellular transformation.

Published
2024

5. Role of CARM1 (PRMT4) in high grade serous ovarian cancer metabolism and function of PRMT5 in ARID1A- deficient endometrial cancer invasion

Author

Perini, Giovanni, Lombardi, Simona <1995>, Perini, Giovanni, and Lombardi, Simona <1995>

Abstract

The arginine methyltransferase CARM1 (PRMT4) is amplified and overexpressed in ~20% of high-grade serous ovarian cancer (HGSOC) and correlates with a poor survival. Therapeutic approaches based on CARM1 expression remain to be an unmet need. Here we show that fatty acid metabolism represents a metabolic vulnerability for HGSOC in a CARM1 expression status dependent manner. CARM1 promotes the de novo synthesis of fatty acids and monounsaturated fatty acids (MUFAs). The disruption of MUFAs synthesis by inhibition of SCD1 results in excessive accumulation of cytotoxic saturated fatty acids and it is synthetic lethal with CARM1 expression. Collectively, our data show that the pharmacological inhibition of MUFAs synthesis via SCD1 inhibition represents a therapeutic strategy for CARM1-high HGSOC. Another arginine methyltransferase, PRMT5, has been identified by our CRISPR screening analysis as a promising candidate for invasive ARID1A-deficient endometrial cancer. Endometrial Cancer frequently harbor somatic inactivating mutation of ARID1A that can promote an invasive phenotype. Our in vitro approach validated the CRISPR screening showing that both PRTM5 knock down and its pharmaceutical inhibition specifically hamper the invasion of ARID1A inactivated cells. Mechanistically, PRMT5 directly regulates the epithelia to mesenchymal transition pathway genes interacting with the SWI/SNF complexes. Moreover, in vivo experiments showed that PRMT5 inhibition contrasted the myometrium invasion highlighting PRMT5 inhibition as promising therapeutic strategy for ARID1A- inactivated aggressive endometrial cancer.

Published
2024

6. Restoration of the molecular clock is tumor suppressive in neuroblastoma

Author

Moreno-Smith, Myrthala, Milazzo, Giorgio, Tao, Ling, Fekry, Baharan, Zhu, Bokai, Mohammad, Mahmoud A., Di Giacomo, Simone, Borkar, Roshan, Reddy, Karthik Reddy Kami, Capasso, Mario, Vasudevan, Sanjeev A., Sumazin, Pavel, Hicks, John, Putluri, Nagireddy, Perini, Giovanni, Eckel-Mahan, Kristin, Burris, Thomas P., and Barbieri, Eveline

Published
2021
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8. PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis

Author

Mzoughi, Slim, Fong, Jia Yi, Papadopoli, David, Koh, Cheryl M., Hulea, Laura, Pigini, Paolo, Di Tullio, Federico, Andreacchio, Giuseppe, Hoppe, Michal Marek, Wollmann, Heike, Low, Diana, Caldez, Matias J., Peng, Yanfen, Torre, Denis, Zhao, Julia N., Uchenunu, Oro, Varano, Gabriele, Motofeanu, Corina-Mihaela, Lakshmanan, Manikandan, Teo, Shun Xie, Wun, Cheng Mun, Perini, Giovanni, Tan, Soo Yong, Ong, Chee Bing, Al-Haddawi, Muthafar, Rajarethinam, Ravisankar, Hue, Susan Swee-Shan, Lim, Soon Thye, Ong, Choon Kiat, Huang, Dachuan, Ng, Siok-Bian, Bernstein, Emily, Hasson, Dan, Wee, Keng Boon, Kaldis, Philipp, Jeyasekharan, Anand, Dominguez-sola, David, Topisirovic, Ivan, and Guccione, Ernesto

Published
2020
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11. Data from c-MYC Oncoprotein Dictates Transcriptional Profiles of ATP-Binding Cassette Transporter Genes in Chronic Myelogenous Leukemia CD34+ Hematopoietic Progenitor Cells

Author

Porro, Antonio, primary, Iraci, Nunzio, primary, Soverini, Simona, primary, Diolaiti, Daniel, primary, Gherardi, Samuele, primary, Terragna, Carolina, primary, Durante, Sandra, primary, Valli, Emanuele, primary, Kalebic, Thea, primary, Bernardoni, Roberto, primary, Perrod, Chiara, primary, Haber, Michelle, primary, Norris, Murray D., primary, Baccarani, Michele, primary, Martinelli, Giovanni, primary, and Perini, Giovanni, primary

Published
2023
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12. Supplementary Figures 1-4, Tables 1-2 from c-MYC Oncoprotein Dictates Transcriptional Profiles of ATP-Binding Cassette Transporter Genes in Chronic Myelogenous Leukemia CD34+ Hematopoietic Progenitor Cells

Author

Porro, Antonio, primary, Iraci, Nunzio, primary, Soverini, Simona, primary, Diolaiti, Daniel, primary, Gherardi, Samuele, primary, Terragna, Carolina, primary, Durante, Sandra, primary, Valli, Emanuele, primary, Kalebic, Thea, primary, Bernardoni, Roberto, primary, Perrod, Chiara, primary, Haber, Michelle, primary, Norris, Murray D., primary, Baccarani, Michele, primary, Martinelli, Giovanni, primary, and Perini, Giovanni, primary

Published
2023
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13. Supplementary Table S1 (Excel file) from The Histone Methyltransferase DOT1L Promotes Neuroblastoma by Regulating Gene Transcription

Author

Wong, Matthew, primary, Tee, Andrew E.L., primary, Milazzo, Giorgio, primary, Bell, Jessica L., primary, Poulos, Rebecca C., primary, Atmadibrata, Bernard, primary, Sun, Yuting, primary, Jing, Duohui, primary, Ho, Nicholas, primary, Ling, Dora, primary, Liu, Pei Yan, primary, Zhang, Xu Dong, primary, Hüttelmaier, Stefan, primary, Wong, Jason W.H., primary, Wang, Jenny, primary, Polly, Patsie, primary, Perini, Giovanni, primary, Scarlett, Christopher J., primary, and Liu, Tao, primary

Published
2023
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14. Supplementary Figure S4 A-E from Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface

Author

Koach, Jessica, primary, Holien, Jessica K., primary, Massudi, Hassina, primary, Carter, Daniel R., primary, Ciampa, Olivia C., primary, Herath, Mika, primary, Lim, Taylor, primary, Seneviratne, Janith A., primary, Milazzo, Giorgio, primary, Murray, Jayne E., primary, McCarroll, Joshua A., primary, Liu, Bing, primary, Mayoh, Chelsea, primary, Keenan, Bryce, primary, Stevenson, Brendan W., primary, Gorman, Michael A., primary, Bell, Jessica L., primary, Doughty, Larissa, primary, Hüttelmaier, Stefan, primary, Oberthuer, Andre, primary, Fischer, Matthias, primary, Gifford, Andrew J., primary, Liu, Tao, primary, Zhang, Xiaoling, primary, Zhu, Shizhen, primary, Gustafson, W. Clay, primary, Haber, Michelle, primary, Norris, Murray D., primary, Fletcher, Jamie I., primary, Perini, Giovanni, primary, Parker, Michael W., primary, Cheung, Belamy B., primary, and Marshall, Glenn M., primary

Published
2023
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15. Supplementary Information from Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface

Author

Koach, Jessica, primary, Holien, Jessica K., primary, Massudi, Hassina, primary, Carter, Daniel R., primary, Ciampa, Olivia C., primary, Herath, Mika, primary, Lim, Taylor, primary, Seneviratne, Janith A., primary, Milazzo, Giorgio, primary, Murray, Jayne E., primary, McCarroll, Joshua A., primary, Liu, Bing, primary, Mayoh, Chelsea, primary, Keenan, Bryce, primary, Stevenson, Brendan W., primary, Gorman, Michael A., primary, Bell, Jessica L., primary, Doughty, Larissa, primary, Hüttelmaier, Stefan, primary, Oberthuer, Andre, primary, Fischer, Matthias, primary, Gifford, Andrew J., primary, Liu, Tao, primary, Zhang, Xiaoling, primary, Zhu, Shizhen, primary, Gustafson, W. Clay, primary, Haber, Michelle, primary, Norris, Murray D., primary, Fletcher, Jamie I., primary, Perini, Giovanni, primary, Parker, Michael W., primary, Cheung, Belamy B., primary, and Marshall, Glenn M., primary

Published
2023
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16. Supplementary Materials and Methods, Figures, Figure Legends - Revised from The Histone Methyltransferase DOT1L Promotes Neuroblastoma by Regulating Gene Transcription

Author

Wong, Matthew, primary, Tee, Andrew E.L., primary, Milazzo, Giorgio, primary, Bell, Jessica L., primary, Poulos, Rebecca C., primary, Atmadibrata, Bernard, primary, Sun, Yuting, primary, Jing, Duohui, primary, Ho, Nicholas, primary, Ling, Dora, primary, Liu, Pei Yan, primary, Zhang, Xu Dong, primary, Hüttelmaier, Stefan, primary, Wong, Jason W.H., primary, Wang, Jenny, primary, Polly, Patsie, primary, Perini, Giovanni, primary, Scarlett, Christopher J., primary, and Liu, Tao, primary

Published
2023
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17. Supplementary Table S2 from The Histone Methyltransferase DOT1L Promotes Neuroblastoma by Regulating Gene Transcription

Author

Wong, Matthew, primary, Tee, Andrew E.L., primary, Milazzo, Giorgio, primary, Bell, Jessica L., primary, Poulos, Rebecca C., primary, Atmadibrata, Bernard, primary, Sun, Yuting, primary, Jing, Duohui, primary, Ho, Nicholas, primary, Ling, Dora, primary, Liu, Pei Yan, primary, Zhang, Xu Dong, primary, Hüttelmaier, Stefan, primary, Wong, Jason W.H., primary, Wang, Jenny, primary, Polly, Patsie, primary, Perini, Giovanni, primary, Scarlett, Christopher J., primary, and Liu, Tao, primary

Published
2023
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18. Data from The Histone Methyltransferase DOT1L Promotes Neuroblastoma by Regulating Gene Transcription

Author

Wong, Matthew, primary, Tee, Andrew E.L., primary, Milazzo, Giorgio, primary, Bell, Jessica L., primary, Poulos, Rebecca C., primary, Atmadibrata, Bernard, primary, Sun, Yuting, primary, Jing, Duohui, primary, Ho, Nicholas, primary, Ling, Dora, primary, Liu, Pei Yan, primary, Zhang, Xu Dong, primary, Hüttelmaier, Stefan, primary, Wong, Jason W.H., primary, Wang, Jenny, primary, Polly, Patsie, primary, Perini, Giovanni, primary, Scarlett, Christopher J., primary, and Liu, Tao, primary

Published
2023
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19. Supplementary Figure S1 F-I from Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface

Author

Koach, Jessica, primary, Holien, Jessica K., primary, Massudi, Hassina, primary, Carter, Daniel R., primary, Ciampa, Olivia C., primary, Herath, Mika, primary, Lim, Taylor, primary, Seneviratne, Janith A., primary, Milazzo, Giorgio, primary, Murray, Jayne E., primary, McCarroll, Joshua A., primary, Liu, Bing, primary, Mayoh, Chelsea, primary, Keenan, Bryce, primary, Stevenson, Brendan W., primary, Gorman, Michael A., primary, Bell, Jessica L., primary, Doughty, Larissa, primary, Hüttelmaier, Stefan, primary, Oberthuer, Andre, primary, Fischer, Matthias, primary, Gifford, Andrew J., primary, Liu, Tao, primary, Zhang, Xiaoling, primary, Zhu, Shizhen, primary, Gustafson, W. Clay, primary, Haber, Michelle, primary, Norris, Murray D., primary, Fletcher, Jamie I., primary, Perini, Giovanni, primary, Parker, Michael W., primary, Cheung, Belamy B., primary, and Marshall, Glenn M., primary

Published
2023
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20. Supplementary Figure S5 F-H from Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface

Author

Koach, Jessica, primary, Holien, Jessica K., primary, Massudi, Hassina, primary, Carter, Daniel R., primary, Ciampa, Olivia C., primary, Herath, Mika, primary, Lim, Taylor, primary, Seneviratne, Janith A., primary, Milazzo, Giorgio, primary, Murray, Jayne E., primary, McCarroll, Joshua A., primary, Liu, Bing, primary, Mayoh, Chelsea, primary, Keenan, Bryce, primary, Stevenson, Brendan W., primary, Gorman, Michael A., primary, Bell, Jessica L., primary, Doughty, Larissa, primary, Hüttelmaier, Stefan, primary, Oberthuer, Andre, primary, Fischer, Matthias, primary, Gifford, Andrew J., primary, Liu, Tao, primary, Zhang, Xiaoling, primary, Zhu, Shizhen, primary, Gustafson, W. Clay, primary, Haber, Michelle, primary, Norris, Murray D., primary, Fletcher, Jamie I., primary, Perini, Giovanni, primary, Parker, Michael W., primary, Cheung, Belamy B., primary, and Marshall, Glenn M., primary

Published
2023
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21. Supplementary Figure S3 F-G from Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface

Author

Koach, Jessica, primary, Holien, Jessica K., primary, Massudi, Hassina, primary, Carter, Daniel R., primary, Ciampa, Olivia C., primary, Herath, Mika, primary, Lim, Taylor, primary, Seneviratne, Janith A., primary, Milazzo, Giorgio, primary, Murray, Jayne E., primary, McCarroll, Joshua A., primary, Liu, Bing, primary, Mayoh, Chelsea, primary, Keenan, Bryce, primary, Stevenson, Brendan W., primary, Gorman, Michael A., primary, Bell, Jessica L., primary, Doughty, Larissa, primary, Hüttelmaier, Stefan, primary, Oberthuer, Andre, primary, Fischer, Matthias, primary, Gifford, Andrew J., primary, Liu, Tao, primary, Zhang, Xiaoling, primary, Zhu, Shizhen, primary, Gustafson, W. Clay, primary, Haber, Michelle, primary, Norris, Murray D., primary, Fletcher, Jamie I., primary, Perini, Giovanni, primary, Parker, Michael W., primary, Cheung, Belamy B., primary, and Marshall, Glenn M., primary

Published
2023
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22. Supplementary Figure S6 A-F from Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface

Author

Koach, Jessica, primary, Holien, Jessica K., primary, Massudi, Hassina, primary, Carter, Daniel R., primary, Ciampa, Olivia C., primary, Herath, Mika, primary, Lim, Taylor, primary, Seneviratne, Janith A., primary, Milazzo, Giorgio, primary, Murray, Jayne E., primary, McCarroll, Joshua A., primary, Liu, Bing, primary, Mayoh, Chelsea, primary, Keenan, Bryce, primary, Stevenson, Brendan W., primary, Gorman, Michael A., primary, Bell, Jessica L., primary, Doughty, Larissa, primary, Hüttelmaier, Stefan, primary, Oberthuer, Andre, primary, Fischer, Matthias, primary, Gifford, Andrew J., primary, Liu, Tao, primary, Zhang, Xiaoling, primary, Zhu, Shizhen, primary, Gustafson, W. Clay, primary, Haber, Michelle, primary, Norris, Murray D., primary, Fletcher, Jamie I., primary, Perini, Giovanni, primary, Parker, Michael W., primary, Cheung, Belamy B., primary, and Marshall, Glenn M., primary

Published
2023
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23. Supplementary Figure S2A-C from Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface

Author

Koach, Jessica, primary, Holien, Jessica K., primary, Massudi, Hassina, primary, Carter, Daniel R., primary, Ciampa, Olivia C., primary, Herath, Mika, primary, Lim, Taylor, primary, Seneviratne, Janith A., primary, Milazzo, Giorgio, primary, Murray, Jayne E., primary, McCarroll, Joshua A., primary, Liu, Bing, primary, Mayoh, Chelsea, primary, Keenan, Bryce, primary, Stevenson, Brendan W., primary, Gorman, Michael A., primary, Bell, Jessica L., primary, Doughty, Larissa, primary, Hüttelmaier, Stefan, primary, Oberthuer, Andre, primary, Fischer, Matthias, primary, Gifford, Andrew J., primary, Liu, Tao, primary, Zhang, Xiaoling, primary, Zhu, Shizhen, primary, Gustafson, W. Clay, primary, Haber, Michelle, primary, Norris, Murray D., primary, Fletcher, Jamie I., primary, Perini, Giovanni, primary, Parker, Michael W., primary, Cheung, Belamy B., primary, and Marshall, Glenn M., primary

Published
2023
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24. Supplementary Figure S6 G-K from Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface

Author

Koach, Jessica, primary, Holien, Jessica K., primary, Massudi, Hassina, primary, Carter, Daniel R., primary, Ciampa, Olivia C., primary, Herath, Mika, primary, Lim, Taylor, primary, Seneviratne, Janith A., primary, Milazzo, Giorgio, primary, Murray, Jayne E., primary, McCarroll, Joshua A., primary, Liu, Bing, primary, Mayoh, Chelsea, primary, Keenan, Bryce, primary, Stevenson, Brendan W., primary, Gorman, Michael A., primary, Bell, Jessica L., primary, Doughty, Larissa, primary, Hüttelmaier, Stefan, primary, Oberthuer, Andre, primary, Fischer, Matthias, primary, Gifford, Andrew J., primary, Liu, Tao, primary, Zhang, Xiaoling, primary, Zhu, Shizhen, primary, Gustafson, W. Clay, primary, Haber, Michelle, primary, Norris, Murray D., primary, Fletcher, Jamie I., primary, Perini, Giovanni, primary, Parker, Michael W., primary, Cheung, Belamy B., primary, and Marshall, Glenn M., primary

Published
2023
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25. Supplementary Dataset 2 from WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma

Author

Sun, Yuting, primary, Bell, Jessica L., primary, Carter, Daniel, primary, Gherardi, Samuele, primary, Poulos, Rebecca C., primary, Milazzo, Giorgio, primary, Wong, Jason W.H., primary, Al-Awar, Rima, primary, Tee, Andrew E., primary, Liu, Pei Y., primary, Liu, Bing, primary, Atmadibrata, Bernard, primary, Wong, Matthew, primary, Trahair, Toby, primary, Zhao, Quan, primary, Shohet, Jason M., primary, Haupt, Ygal, primary, Schulte, Johannes H., primary, Brown, Peter J., primary, Arrowsmith, Cheryl H., primary, Vedadi, Masoud, primary, MacKenzie, Karen L., primary, Hüttelmaier, Stefan, primary, Perini, Giovanni, primary, Marshall, Glenn M., primary, Braithwaite, Antony, primary, and Liu, Tao, primary

Published
2023
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26. Supplementary Dataset 1 from WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma

Author

Sun, Yuting, primary, Bell, Jessica L., primary, Carter, Daniel, primary, Gherardi, Samuele, primary, Poulos, Rebecca C., primary, Milazzo, Giorgio, primary, Wong, Jason W.H., primary, Al-Awar, Rima, primary, Tee, Andrew E., primary, Liu, Pei Y., primary, Liu, Bing, primary, Atmadibrata, Bernard, primary, Wong, Matthew, primary, Trahair, Toby, primary, Zhao, Quan, primary, Shohet, Jason M., primary, Haupt, Ygal, primary, Schulte, Johannes H., primary, Brown, Peter J., primary, Arrowsmith, Cheryl H., primary, Vedadi, Masoud, primary, MacKenzie, Karen L., primary, Hüttelmaier, Stefan, primary, Perini, Giovanni, primary, Marshall, Glenn M., primary, Braithwaite, Antony, primary, and Liu, Tao, primary

Published
2023
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27. Supplementary Dataset 5 from WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma

Author

Sun, Yuting, primary, Bell, Jessica L., primary, Carter, Daniel, primary, Gherardi, Samuele, primary, Poulos, Rebecca C., primary, Milazzo, Giorgio, primary, Wong, Jason W.H., primary, Al-Awar, Rima, primary, Tee, Andrew E., primary, Liu, Pei Y., primary, Liu, Bing, primary, Atmadibrata, Bernard, primary, Wong, Matthew, primary, Trahair, Toby, primary, Zhao, Quan, primary, Shohet, Jason M., primary, Haupt, Ygal, primary, Schulte, Johannes H., primary, Brown, Peter J., primary, Arrowsmith, Cheryl H., primary, Vedadi, Masoud, primary, MacKenzie, Karen L., primary, Hüttelmaier, Stefan, primary, Perini, Giovanni, primary, Marshall, Glenn M., primary, Braithwaite, Antony, primary, and Liu, Tao, primary

Published
2023
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28. Supplementary Figures from MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin

Author

O'Brien, Rosemary, primary, Tran, Sieu L., primary, Maritz, Michelle F., primary, Liu, Bing, primary, Kong, Cheng Fei, primary, Purgato, Stefania, primary, Yang, Chen, primary, Murray, Jayne, primary, Russell, Amanda J., primary, Flemming, Claudia L., primary, von Jonquieres, Georg, primary, Pickett, Hilda A., primary, London, Wendy B., primary, Haber, Michelle, primary, Gunaratne, Preethi H., primary, Norris, Murray D., primary, Perini, Giovanni, primary, Fletcher, Jamie I., primary, and MacKenzie, Karen L., primary

Published
2023
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30. Supplementary Dataset 4 from WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma

Author

Sun, Yuting, primary, Bell, Jessica L., primary, Carter, Daniel, primary, Gherardi, Samuele, primary, Poulos, Rebecca C., primary, Milazzo, Giorgio, primary, Wong, Jason W.H., primary, Al-Awar, Rima, primary, Tee, Andrew E., primary, Liu, Pei Y., primary, Liu, Bing, primary, Atmadibrata, Bernard, primary, Wong, Matthew, primary, Trahair, Toby, primary, Zhao, Quan, primary, Shohet, Jason M., primary, Haupt, Ygal, primary, Schulte, Johannes H., primary, Brown, Peter J., primary, Arrowsmith, Cheryl H., primary, Vedadi, Masoud, primary, MacKenzie, Karen L., primary, Hüttelmaier, Stefan, primary, Perini, Giovanni, primary, Marshall, Glenn M., primary, Braithwaite, Antony, primary, and Liu, Tao, primary

Published
2023
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31. Supplementary Figure Legends from MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin

Author

O'Brien, Rosemary, primary, Tran, Sieu L., primary, Maritz, Michelle F., primary, Liu, Bing, primary, Kong, Cheng Fei, primary, Purgato, Stefania, primary, Yang, Chen, primary, Murray, Jayne, primary, Russell, Amanda J., primary, Flemming, Claudia L., primary, von Jonquieres, Georg, primary, Pickett, Hilda A., primary, London, Wendy B., primary, Haber, Michelle, primary, Gunaratne, Preethi H., primary, Norris, Murray D., primary, Perini, Giovanni, primary, Fletcher, Jamie I., primary, and MacKenzie, Karen L., primary

Published
2023
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32. Data from N-Myc Regulates Expression of the Detoxifying Enzyme Glutathione Transferase GSTP1, a Marker of Poor Outcome in Neuroblastoma

Author

Fletcher, Jamie I., primary, Gherardi, Samuele, primary, Murray, Jayne, primary, Burkhart, Catherine A., primary, Russell, Amanda, primary, Valli, Emanuele, primary, Smith, Janice, primary, Oberthuer, André, primary, Ashton, Lesley J., primary, London, Wendy B., primary, Marshall, Glenn M., primary, Norris, Murray D., primary, Perini, Giovanni, primary, and Haber, Michelle, primary

Published
2023
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33. Data from WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma

Author

Sun, Yuting, primary, Bell, Jessica L., primary, Carter, Daniel, primary, Gherardi, Samuele, primary, Poulos, Rebecca C., primary, Milazzo, Giorgio, primary, Wong, Jason W.H., primary, Al-Awar, Rima, primary, Tee, Andrew E., primary, Liu, Pei Y., primary, Liu, Bing, primary, Atmadibrata, Bernard, primary, Wong, Matthew, primary, Trahair, Toby, primary, Zhao, Quan, primary, Shohet, Jason M., primary, Haupt, Ygal, primary, Schulte, Johannes H., primary, Brown, Peter J., primary, Arrowsmith, Cheryl H., primary, Vedadi, Masoud, primary, MacKenzie, Karen L., primary, Hüttelmaier, Stefan, primary, Perini, Giovanni, primary, Marshall, Glenn M., primary, Braithwaite, Antony, primary, and Liu, Tao, primary

Published
2023
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34. Supplementary Dataset 3 from WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma

Author

Sun, Yuting, primary, Bell, Jessica L., primary, Carter, Daniel, primary, Gherardi, Samuele, primary, Poulos, Rebecca C., primary, Milazzo, Giorgio, primary, Wong, Jason W.H., primary, Al-Awar, Rima, primary, Tee, Andrew E., primary, Liu, Pei Y., primary, Liu, Bing, primary, Atmadibrata, Bernard, primary, Wong, Matthew, primary, Trahair, Toby, primary, Zhao, Quan, primary, Shohet, Jason M., primary, Haupt, Ygal, primary, Schulte, Johannes H., primary, Brown, Peter J., primary, Arrowsmith, Cheryl H., primary, Vedadi, Masoud, primary, MacKenzie, Karen L., primary, Hüttelmaier, Stefan, primary, Perini, Giovanni, primary, Marshall, Glenn M., primary, Braithwaite, Antony, primary, and Liu, Tao, primary

Published
2023
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35. Supplementary Methods from MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin

Author

O'Brien, Rosemary, primary, Tran, Sieu L., primary, Maritz, Michelle F., primary, Liu, Bing, primary, Kong, Cheng Fei, primary, Purgato, Stefania, primary, Yang, Chen, primary, Murray, Jayne, primary, Russell, Amanda J., primary, Flemming, Claudia L., primary, von Jonquieres, Georg, primary, Pickett, Hilda A., primary, London, Wendy B., primary, Haber, Michelle, primary, Gunaratne, Preethi H., primary, Norris, Murray D., primary, Perini, Giovanni, primary, Fletcher, Jamie I., primary, and MacKenzie, Karen L., primary

Published
2023
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36. Supplementary Tables 1-6, Figures 1-4 from N-Myc Regulates Expression of the Detoxifying Enzyme Glutathione Transferase GSTP1, a Marker of Poor Outcome in Neuroblastoma

Author

Fletcher, Jamie I., primary, Gherardi, Samuele, primary, Murray, Jayne, primary, Burkhart, Catherine A., primary, Russell, Amanda, primary, Valli, Emanuele, primary, Smith, Janice, primary, Oberthuer, André, primary, Ashton, Lesley J., primary, London, Wendy B., primary, Marshall, Glenn M., primary, Norris, Murray D., primary, Perini, Giovanni, primary, and Haber, Michelle, primary

Published
2023
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39. Supplementary Figure 6 from MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin

Author

O'Brien, Rosemary, primary, Tran, Sieu L., primary, Maritz, Michelle F., primary, Liu, Bing, primary, Kong, Cheng Fei, primary, Purgato, Stefania, primary, Yang, Chen, primary, Murray, Jayne, primary, Russell, Amanda J., primary, Flemming, Claudia L., primary, von Jonquieres, Georg, primary, Pickett, Hilda A., primary, London, Wendy B., primary, Haber, Michelle, primary, Gunaratne, Preethi H., primary, Norris, Murray D., primary, Perini, Giovanni, primary, Fletcher, Jamie I., primary, and MacKenzie, Karen L., primary

Published
2023
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40. Supplementary Methods-Figures-Tables from WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma

Author

Sun, Yuting, primary, Bell, Jessica L., primary, Carter, Daniel, primary, Gherardi, Samuele, primary, Poulos, Rebecca C., primary, Milazzo, Giorgio, primary, Wong, Jason W.H., primary, Al-Awar, Rima, primary, Tee, Andrew E., primary, Liu, Pei Y., primary, Liu, Bing, primary, Atmadibrata, Bernard, primary, Wong, Matthew, primary, Trahair, Toby, primary, Zhao, Quan, primary, Shohet, Jason M., primary, Haupt, Ygal, primary, Schulte, Johannes H., primary, Brown, Peter J., primary, Arrowsmith, Cheryl H., primary, Vedadi, Masoud, primary, MacKenzie, Karen L., primary, Hüttelmaier, Stefan, primary, Perini, Giovanni, primary, Marshall, Glenn M., primary, Braithwaite, Antony, primary, and Liu, Tao, primary

Published
2023
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41. Supplementary Tables from MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin

Author

O'Brien, Rosemary, primary, Tran, Sieu L., primary, Maritz, Michelle F., primary, Liu, Bing, primary, Kong, Cheng Fei, primary, Purgato, Stefania, primary, Yang, Chen, primary, Murray, Jayne, primary, Russell, Amanda J., primary, Flemming, Claudia L., primary, von Jonquieres, Georg, primary, Pickett, Hilda A., primary, London, Wendy B., primary, Haber, Michelle, primary, Gunaratne, Preethi H., primary, Norris, Murray D., primary, Perini, Giovanni, primary, Fletcher, Jamie I., primary, and MacKenzie, Karen L., primary

Published
2023
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43. Harnessing the cellular and molecular complexity of high-risk neuroblastoma to investigate novel potential treatment approaches

Author

Perini, Giovanni, De Rosa, Piergiuseppe <1995>, Perini, Giovanni, and De Rosa, Piergiuseppe <1995>

Abstract

Neuroblastoma (NB) is the most common type of tumor in infants and the third most common cancer in children. Current clinical practices employ a variety of strategies for NB treatment, ranging from standard chemotherapy to immunotherapy. Due to a lack of knowledge about the molecular mechanisms underlying the disease's onset, aggressive phenotype, and therapeutic resistance, these approaches are ineffective in the majority of instances. MYCN amplification is one of the most well-known genetic alterations associated with high risk in NB. The following work is divided into three sections and aims to provide new insights into the biology of NB and hypothetical new treatment strategies. First, we identified RUNX1T1 as a key gene involved in MYCN-driven NB onset in a transgenic mouse model. Our results suggested that that RUNX1T1 may recruit the Co-REST complex on target genes that regulate the differentiation of NB cells and that the interaction with RCOR3 is essential. Second, we provided insights into the role of MYCN in dysregulating the CDK/RB/E2F pathway controlling the G1/S transition of the cell cycle. We found that RB is dispensable in regulating MYCN amplified NB's cell cycle, providing the rationale for using cyclin/CDK complexes inhibitors in NBs carrying MYCN amplification and relatively high levels of RB1 expression. Third, we generated an M13 bacteriophage platform to target GD2-expressing cells in NB. Here, we generated a recombinant M13 phage capable of binding GD2-expressing cells selectively (M13GD2). Our results showed that M13GD2 chemically conjugated with the photosensitizer ECB04 preserves the retargeting capability, inducing cell death even at picomolar concentrations upon light irradiation. These results provided proof of concept for M13 phage employment in targeted photodynamic therapy for NB, an exciting strategy to overcome resistance to classical immunotherapy.

Published
2023

44. JMJD6 is a tumorigenic factor and therapeutic target in neuroblastoma

Author

Wong, Matthew, Sun, Yuting, Xi, Zhichao, Milazzo, Giorgio, Poulos, Rebecca C., Bartenhagen, Christoph, Bell, Jessica L., Mayoh, Chelsea, Ho, Nicholas, Tee, Andrew E., Chen, Xiaoqiong, Li, Yang, Ciaccio, Roberto, Liu, Pei Y., Jiang, Chen C., Lan, Qing, Jayatilleke, Nisitha, Cheung, Belamy B., Haber, Michelle, Norris, Murray D., Zhang, Xu D., Marshall, Glenn M., Wang, Jenny Y., Hüttelmaier, Stefan, Fischer, Matthias, Wong, Jason W. H., Xu, Hongxi, Perini, Giovanni, Dong, Qihan, George, Rani E., and Liu, Tao

Published
2019
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46. Bipolar Spectrum Symptoms in Patients with Fibromyalgia: A Dimensional Psychometric Evaluation of 120 Patients

Author

Schweiger, Vittorio, primary, Perini, Giovanni, additional, Del Piccolo, Lidia, additional, Perlini, Cinzia, additional, Donisi, Valeria, additional, Gottin, Leonardo, additional, Martini, Alvise, additional, Donadello, Katia, additional, Del Balzo, Giovanna, additional, Moro, Valentina, additional, Secchettin, Erica, additional, and Polati, Enrico, additional

Published
2022
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49. Off-label long acting injectable antipsychotics in real-world clinical practice: a cross-sectional analysis of prescriptive patterns from the STAR Network DEPOT study

Author

D'Agostino, Armando, Aguglia, Andrea, Barbui, Corrado, Bartoli, Francesco, Carrà, Giuseppe, Cavallotti, Simone, Chirico, Margherita, Ostinelli, Edoardo G, Zangani, Caroline, Martinotti, Giovanni, Ostuzzi, Giovanni, Bertolini, Federico, Calandra, Carmela, Callegari, Camilla, D’Agostino, Armando, Lucii, Claudio, Mastromo, Daniele, Moretti, Daniele, Monzani, Emiliano, Porcellana, Matteo, Prestia, Davide, Nose, Michela, Purgato, Marianna, Turrini, Giulia, Mazzi, Maria, Angela, Papola, Davide, Gastaldon, Chiara, Terlizzi, Samira, Piccoli, Alberto, Ruggeri, Mirella, De Fazio, Pasquale, Magliocco, Fabio, Caroleo, Mariarita, Raffaele, Gaetano, Ostinelli, Edoardo, Giuseppe, Bolognesi, Simone, Debolini, Sara, Pierantozzi, Elisa, Fargnoli, Francesco, Del Zanna, Maria, Giannini, Alessandra, Luccarelli, Livia, De Capua, Alberto, Annese, Pasqua, Maria, Cerretini, Massimiliano, Tozzi, Fiorella, Magnani, Nadia, Cardamone, Giuseppe, Bardicchia, Francesco, Facchi, Edvige, Soscia, Federica, Zotos, Spyridon, Biancosino, Bruno, Zonta, Filippo, Pompei, Francesco, Zizolfi, Daniele, Ielmini, Marta, Caselli, Ivano, Giana, Edoardo, Buzzi, Aldo, Emanuele, Diurni, Marcello, Milano, Anna, Sani, Emanuele, Calzolari, Roberta, Bortolaso, Paola, Piccinelli, Marco, Cazzamalli, Sara, Caterina, Alberini, Gabro, Piantanida, Silvia, Costantini, Chiara, Paronelli, Chiara, Di Caro, Angela, Moretti, Valentina, Gozzi, Mauro, D'Ippolito, Chiara, Barbanti Silva, Veronica, Papalini, Alessandro, Corbo, Mariangela, Campese, Ornella, Fiori, Federica, Lorusso, Marco, Di Capro, Lucia, Viceconte, Daniela, Mancini, Valerio, Suraniti, Francesco, Signorelli, Maria, Salvina, Rossi, Eugenio, Lupoli, Pasqualino, Menchetti, Marco, Terzi, Laura, Boso, Marianna, Risaro, Paolo, De Paoli, Giuseppe, Catania, Cristina, Tarricone, Ilaria, Caretto, Valentina, Storbini, Viviana, Emiliani, Roberta, Balzarro, Beatrice, Carra, Giuseppe, Tabacchi, Tommaso, Nava, Roberto, Bono, Adele, Provenzi, Milena, Brambilla, Giulia, Aspesi, Flora, Tremolada, Martina, Castagna, Gloria, Bava, Mattia, Verrengia, Enrica, Lucchi, Sara, Oriani, Maria, Ginevra, Barchiesi, Michela, Pacetti, Monica, Magni, Laura, Rosa, Rossi, Giuseppe, Beneduce, Rossella, Tura, Giovanni, Battista, Laffranchini, Laura, Ferrato, Farida, Restaino, Francesco, Limosani, Ivan, Ghio, Lucio, Ferro, Maurizio, Parise, Vincenzo, Fricchione, Balletta, Giovanni, Addeo, Lelio, De Vivo, Elisa, Di Benedetto, Rossella, Pinna, Federica, Carpiniello, Bernardo, Spano, Mariangela, Giacomin, Marzio, Pecile, Damiano, Mattei, Chiara, Fabrici, Elisabetta, Pascolo, Panarello, Sofia, Peresson, Giulia, Vitucci, Claudio, Bonavigo, Tommaso, Perini, Giovanni, Boschello, Filippo, Strizzolo, Stefania, Gardellin, Francesco, Di Giannantonio, Massimo, Fizzotti, Carlo, Cossetta, Edoardo, Di Gregorio, Luana, Sozzi, Francesca, Boncompagni, Giancarlo, La Barbera, Daniele, Colli, Giuseppe, Laurenzi, Sabrina, Luca, Maria, D'Agostino A., Aguglia A., Barbui C., Bartoli F., Carra G., Cavallotti S., Chirico M., Ostinelli E.G., Zangani C., Martinotti G., Ostuzzi G., Nose M., Purgato M., Turrini G., Mazzi M.A., Papola D., Gastaldon C., Terlizzi S., Bertolini F., Piccoli A., Ruggeri M., De Fazio P., Magliocco F., Caroleo M., Raffaele G., Bergamelli E., Lucii C., Bolognesi S., Debolini S., Pierantozzi E., Fargnoli F., Del Zanna M., Giannini A., Luccarelli L., De Capua A., Annese P.M., Cerretini M., Tozzi F., Magnani N., Cardamone G., Bardicchia F., Facchi E., Soscia F., Zotos S., Biancosino B., Zonta F., Pompei F., Callegari C., Zizolfi D., Poloni N., Ielmini M., Caselli I., Giana E., Buzzi A., Diurni M., Milano A., Sani E., Calzolari R., Bortolaso P., Piccinelli M., Cazzamalli S., Alberini G., Piantanida S., Costantini C., Paronelli C., Di Caro A., Moretti V., Gozzi M., D'Ippolito C., Barbanti S.V., Alessandro P., Corbo M., Campese O., Fiori F., Lorusso M., Di Capro L., Viceconte D., Mancini V., Suraniti F., Signorelli M.S., Rossi E., Lupoli P., Menchetti M., Terzi L., Boso M., Risaro P., De Paoli G., Catania C., Tarricone I., Caretto V., Storbini V., Emiliani R., Balzarro B., Tabacchi T., Nava R., Bono A., Provenzi M., Brambilla G., Aspesi F., Trotta G., Tremolada M., Castagna G., Bava M., Verrengia E., Lucchi S., Oriani M.G., Barchiesi M., Pacetti M., Amerio A., Amore M., Serafini G., Magni L.R., Rossi G., Beneduce R., Tura G.B., Laffranchini L., Mastromo D., Ferrato F., Restaino F., Monzani E., Porcellana M., Limosani I., Ghio L., Ferro M., Parise V.F., Balletta G., Addeo L., De Vivo E., Di Benedetto R., Pinna F., Carpiniello B., Spano M., Giacomin M., Pecile D., Mattei C., Fabrici E.P., Panarello S., Peresson G., Vitucci C., Bonavigo T., Perini G., Boschello F., Strizzolo S., Gardellin F., di Giannantonio M., Moretti D., Fizzotti C., Cossetta E., Di Gregorio L., Sozzi F., Boncompagni G., La Barbera D., Colli G., Laurenzi S., Calandra C., Luca M., D'Agostino, A, Aguglia, A, Barbui, C, Bartoli, F, Carra, G, Cavallotti, S, Chirico, M, Ostinelli, E, Zangani, C, Martinotti, G, Ostuzzi, G, D'Agostino, Armando, Aguglia, Andrea, Barbui, Corrado, Bartoli, Francesco, Carrà, Giuseppe, Cavallotti, Simone, Chirico, Margherita, Ostinelli, Edoardo G, Zangani, Caroline, Martinotti, Giovanni, Ostuzzi, Giovanni, and LA BARBERA, DANIELE

Subjects
Long-acting injectable antipsychotic, Cross-Sectional Studies, Off-label, Personality disorder, Bipolar disorder, Delayed-Action Preparations, Schizophrenia, Humans, Long-acting injectable antipsychotics, Off-Label Use, Antipsychotic Agents, Settore MED/25 - Psichiatria
Abstract

Introduction: Information on the off–label use of Long–Acting Injectable (LAI) antipsychotics in the real world is lacking. In this study, we aimed to identify the sociodemographic and clinical features of patients treated with on– vs off–label LAIs and predictors of off–label First– or Second–Generation Antipsychotic (FGA vs. SGA) LAI choice in everyday clinical practice. Method: In a naturalistic national cohort of 449 patients who initiated LAI treatment in the STAR Network Depot Study, two groups were identified based on off– or on–label prescriptions. A multivariate logistic regression analysis was used to test several clinically relevant variables and identify those associated with the choice of FGA vs SGA prescription in the off–label group. Results: SGA LAIs were more commonly prescribed in everyday practice, without significant differences in their on– and off–label use. Approximately 1 in 4 patients received an off–label prescription. In the off–label group, the most frequent diagnoses were bipolar disorder (67.5%) or any personality disorder (23.7%). FGA vs SGA LAI choice was significantly associated with BPRS thought disorder (OR = 1.22, CI95% 1.04 to 1.43, p= 0.015) and hostility/suspiciousness (OR = 0.83, CI95% 0.71 to 0.97, p= 0.017) dimensions. The likelihood of receiving an SGA LAI grew steadily with the increase of the BPRS thought disturbance score. Conversely, a preference towards prescribing an FGA was observed with higher scores at the BPRS hostility/suspiciousness subscale. Conclusion: Our study is the first to identify predictors of FGA vs SGA choice in patients treated with off–label LAI antipsychotics. Demographic characteristics, i.e. age, sex, and substance/alcohol use co–morbidities did not appear to influence the choice towards FGAs or SGAs. Despite a lack of evidence, clinicians tend to favour FGA over SGA LAIs in bipolar or personality disorder patients with relevant hostility. Further research is needed to evaluate treatment adherence and clinical effectiveness of these prescriptive patterns.

Published
2022

50. Centromere sliding on a mammalian chromosome

Author

Purgato, Stefania, Belloni, Elisa, Piras, Francesca M., Zoli, Monica, Badiale, Claudia, Cerutti, Federico, Mazzagatti, Alice, Perini, Giovanni, Della Valle, Giuliano, Nergadze, Solomon G., Sullivan, Kevin F., Raimondi, Elena, Rocchi, Mariano, and Giulotto, Elena

Published
2015
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