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1. The Northern Cross Fast Radio Burst project IV. Multi-wavelength study of the actively repeating FRB 20220912A

Author

Pelliciari, D., Bernardi, G., Pilia, M., Naldi, G., Maccaferri, G., Verrecchia, F., Casentini, C., Perri, M., Kirsten, F., Bianchi, G., Bortolotti, C., Bruno, L., Dallacasa, D., Esposito, P., Geminardi, A., Giarratana, S., Giroletti, M., Lulli, R., Maccaferri, A., Magro, A., Mattana, A., Perini, F., Pupillo, G., Roma, M., Schiaffino, M., Setti, G., Tavani, M., Trudu, M., and Zanichelli, A.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

Fast radio bursts (FRBs) are energetic, millisecond-duration radio pulses observed at extragalactic distances and whose origins are still a subject of heated debate. A fraction of the FRB population have shown repeating bursts, however it's still unclear whether these represent a distinct class of sources. We investigated the bursting behaviour of FRB 20220912A, one of the most active repeating FRBs known thus far. In particular, we focused on its burst energy distribution, linked to the source energetics, and its emission spectrum, with the latter directly related to the underlying emission mechanism. We monitored FRB 20220912A at $408$ MHz with the Northern Cross radio telescope and at $1.4$ GHz using the $32$-m Medicina Grueff radio telescope. Additionally, we conducted $1.2$ GHz observations taken with the upgraded Giant Meter Wave Radio Telescope (uGMRT) searching for a persistent radio source coincident with FRB 20220912A, which included high energy observations in the $0.3-10$ keV, $0.4-100$ MeV and $0.03-30$ GeV energy range. We report $16$ new bursts from FRB 20220912A at $408$ MHz during the period between October 16$^{\rm th}$ 2022 and December 31$^{\rm st}$ 2023. Their cumulative spectral energy distribution follows a power law with slope $\alpha_E = -1.3 \pm 0.2$ and we measured a repetition rate of $0.19 \pm 0.03$ hr$^{-1}$ for bursts having a fluence of $\mathcal{F} \geq 17$ Jy ms. Furthermore, we report no detections at 1.4 GHz for $\mathcal{F} \geq 20$ Jy ms. These non-detections imply an upper limit of $\beta < -2.3$, with $\beta$ being the $408$ MHz $-$ $1.4$ GHz spectral index of FRB 20220912A. This is inconsistent with positive $\beta$ values found for the only two known cases in which an FRB has been detected in separate spectral bands. We find that FRB 20220912A shows a decline of four orders of magnitude in its bursting activity at $1.4$ GHz over a .. (abridged), Comment: accepted for publication, 13 pages, 4 figures

Published
2024

2. The Northern Cross Fast Radio Burst project - II. Monitoring of repeating FRB 20180916B, 20181030A, 20200120E and 20201124A

Author

Trudu, M., Pilia, M., Bernardi, G., Addis, A., Bianchi, G., Magro, A., Naldi, G., Pelliciari, D., Pupillo, G., Setti, G., Bortolotti, C., Casentini, C., Dallacasa, D., Gajjar, V., Locatelli, N., Lulli, R., Maccaferri, G., Mattana, A., Michilli, D., Perini, F., Possenti, A., Roma, M., Schiaffino, M., Tavani, M., and Verrecchia, F.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

In this work we report the results of a nineteen-month Fast Radio Burst observational campaign carried out with the North-South arm of the Medicina Northern Cross radio telescope at 408~MHz in which we monitored four repeating sources: FRB20180916B, FRB20181030A, FRB20200120E and FRB20201124A. We present the current state of the instrument and the detection and characterisation of three bursts from FRB20180916B. Given our observing time, our detections are consistent with the event number we expect from the known burst rate ($2.7 \pm 1.9$ above our 10$\sigma$, 38~Jy~ms detection threshold) in the 5.2 day active window of the source, further confirming the source periodicity. We detect no bursts from the other sources. We turn this result into a 95\% confidence level lower limit on the slope of the differential fluence distribution $\alpha$ to be $\alpha > 2.1$ and $\alpha > 2.2$ for FRB20181030A and FRB20200120E respectively. Given the known rate for FRB20201124A, we expect $1.0 \pm 1.1$ bursts from our campaign, consistent with our non-detection., Comment: MNRAS Accepted, 10 pages, 6 figures

Published
2022
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3. The Aperture Array Verification System 1: System overview and early commissioning results

Author

Benthem, P., Wayth, R., Acedo, E. de Lera, Adami, K. Zarb, Alderighi, M., Belli, C., Bolli, P., Booler, T., Borg, J., Broderick, J. W., Chiarucci, S., Chiello, R., Ciani, L., Comoretto, G., Crosse, B., Davidson, D., DeMarco, A., Emrich, D., van Es, A., Fierro, D., Faulkner, A., Gerbers, M., Razavi-Ghods, N., Hall, P., Horsley, L., Juswardy, B., Kenney, D., Steele, K., Magro, A., Mattana, A., McKinley, B., Monari, J., Naldi, G., Nanni, J., Di Ninni, P., Paonessa, F., Perini, F., Poloni, M., Pupillo, G., Rusticelli, S., Schiaffino, M., Schillirò, F., Schnetler, H., Singuaroli, R., Sokolowski, M., Sutinjo, A., Tartarini, G., Ung, D., de Vaate, J. G. Bij, Virone, G., Walker, M., Waterson, M., Wijnholds, S. J., and Williams, A.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The design and development process for the Square Kilometre Array (SKA) radio telescope, the Low Frequency Aperture Array component, was progressed during the SKA pre-construction phase by an international consortium, with the goal of meeting requirements for a critical design review. As part of the development process a full-sized prototype SKA Low station was deployed, the Aperture Array Verification System 1 (AAVS1). We provide a system overview and describe the commissioning results of AAVS1, which is a low frequency radio telescope with 256 dual-polarisation log-periodic dipole antennas working as a phased array. A detailed system description is provided, including an in-depth overview of relevant sub-systems, ranging from hardware, firmware, software, calibration,and control sub-systems. Early commissioning results cover initial bootstrapping, array calibration, stability testing, beam-forming,and on-sky sensitivity validation. Lessons learned are presented, along with future developments.

Published
2021
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4. A Southern-Hemisphere all-sky radio transient monitor for SKA-Low prototype stations

Author

Sokolowski, M., Wayth, R. B., Bhat, N. D. R., Price, D., Broderick, J. W., Bernardi, G., Bolli, P., Chiello, R., Comoretto, G., Crosse, B., Davidson, D. B., Macario, G., Magro, A., Mattana, A., Minchin, D., McPhail, A., Monari, J., Perini, F., Pupillo, G., Sleap, G., Tingay, S., Ung, D., and Williams, A.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract

We present the first southern-hemisphere all-sky imager and radio-transient monitoring system implemented on two prototype stations of the low-frequency component of the Square Kilometre Array. Since its deployment the system has been used for real-time monitoring of the recorded commissioning data. Additionally, a transient searching algorithm has been executed on the resulting all-sky images. It uses a difference imaging technique, and has enabled identification of a wide variety of transient classes, ranging from human-made radio-frequency interference to genuine astrophysical events. Observations at the frequency 159.4 MHz and higher in a single coarse channel (0.926 MHz) were made with 2s time resolution, and multiple nights were analysed. Despite having modest sensitivity (~few Jy/beam), using a single coarse channel and 2-s imaging, the system detected bright transients from PSR B0950+08, proving that it can be used to detect bright transients of an astrophysical origin. The unusual, extreme activity of the pulsar PSR B0950+08 (up to ~155 Jy/beam) was initially detected in a "blind" search in the 2020-04-10/11 data and later assigned to this specific pulsar. The limitations of our data, however, prevent use from making firm conclusions of the effect being due to a combination of refractive and diffractive scintillation or intrinsic emission mechanisms. The system can routinely collect data over many days without interruptions; the large amount of recorded data at 159.4 and 229.7 MHz allowed us to determine a preliminary transient surface density upper limit of $1.32 \times 10^{-9} \text{deg}^{-2}$ for a timescale and limiting flux density of 2s and 42 Jy, respectively. We plan to extend the observing bandwidth to tens of MHz and improve time resolution to tens of milliseconds in order to increase the sensitivity and enable detections of Fast Radio Bursts below 300 MHz., Comment: 22 pages, 11 figures, 3 tables, Accepted for publication in PASA

Published
2021
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6. The Northern Cross Fast Radio Burst project. III. The FRB-magnetar connection in a sample of nearby galaxies

Author

Pelliciari, D., primary, Bernardi, G., additional, Pilia, M., additional, Naldi, G., additional, Pupillo, G., additional, Trudu, M., additional, Addis, A., additional, Bianchi, G., additional, Bortolotti, C., additional, Dallacasa, D., additional, Lulli, R., additional, Maccaferri, G., additional, Magro, A., additional, Mattana, A., additional, Perini, F., additional, Roma, M., additional, Schiaffino, M., additional, Setti, G., additional, Tavani, M., additional, Verrecchia, F., additional, and Casentini, C., additional

Published
2023
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11. The northern cross fast radio burst project - II. monitoring of repeating FRB 20180916B, 20181030A, 20200120E and 20201124A

Author

Trudu, M, primary, Pilia, M, additional, Bernardi, G, additional, Addis, A, additional, Bianchi, G, additional, Magro, A, additional, Naldi, G, additional, Pelliciari, D, additional, Pupillo, G, additional, Setti, G, additional, Bortolotti, C, additional, Casentini, C, additional, Dallacasa, D, additional, Gajjar, V, additional, Locatelli, N, additional, Lulli, R, additional, Maccaferri, G, additional, Mattana, A, additional, Michilli, D, additional, Perini, F, additional, Possenti, A, additional, Roma, M, additional, Schiaffino, M, additional, Tavani, M, additional, and Verrecchia, F, additional

Published
2022
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15. The Aperture Array Verification System 1: System overview and early commissioning results

Author

Benthem, P., primary, Wayth, R., additional, de Lera Acedo, E., additional, Zarb Adami, K., additional, Alderighi, M., additional, Belli, C., additional, Bolli, P., additional, Booler, T., additional, Borg, J., additional, Broderick, J. W., additional, Chiarucci, S., additional, Chiello, R., additional, Ciani, L., additional, Comoretto, G., additional, Crosse, B., additional, Davidson, D., additional, DeMarco, A., additional, Emrich, D., additional, van Es, A., additional, Fierro, D., additional, Faulkner, A., additional, Gerbers, M., additional, Razavi-Ghods, N., additional, Hall, P., additional, Horsley, L., additional, Juswardy, B., additional, Kenney, D., additional, Steele, K., additional, Magro, A., additional, Mattana, A., additional, McKinley, B., additional, Monari, J., additional, Naldi, G., additional, Nanni, J., additional, Di Ninni, P., additional, Paonessa, F., additional, Perini, F., additional, Poloni, M., additional, Pupillo, G., additional, Rusticelli, S., additional, Schiaffino, M., additional, Schillirò, F., additional, Schnetler, H., additional, Singuaroli, R., additional, Sokolowski, M., additional, Sutinjo, A., additional, Tartarini, G., additional, Ung, D., additional, Bij de Vaate, J. G., additional, Virone, G., additional, Walker, M., additional, Waterson, M., additional, Wijnholds, S. J., additional, and Williams, A., additional

Published
2021
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18. northern cross fast radio burst project – II. Monitoring of repeating FRB 20180916B, 20181030A, 20200120E, and 20201124A.

Author

Trudu, M, Pilia, M, Bernardi, G, Addis, A, Bianchi, G, Magro, A, Naldi, G, Pelliciari, D, Pupillo, G, Setti, G, Bortolotti, C, Casentini, C, Dallacasa, D, Gajjar, V, Locatelli, N, Lulli, R, Maccaferri, G, Mattana, A, Michilli, D, and Perini, F

Subjects
RADIO telescopes
Abstract

In this work, we report the results of a 19-month fast radio burst observational campaign carried out with the north–south arm of the Medicina Northern Cross radio telescope at 408 MHz in which we monitored four repeating sources: FRB20180916B, FRB20181030A, FRB20200120E, and FRB20201124A. We present the current state of the instrument and the detection and characterization of three bursts from FRB20180916B. Given our observing time, our detections are consistent with the event number we expect from the known burst rate (2.7 ± 1.9 above our 10σ, 38 Jy ms detection threshold) in the 5.2 d active window of the source, further confirming the source periodicity. We detect no bursts from the other sources. We turn this result into a 95 per cent confidence level lower limit on the slope of the differential fluence distribution α to be α > 2.1 and α > 2.2 for FRB20181030A and FRB20200120E, respectively. Given the known rate for FRB20201124A, we expect 1.0 ± 1.1 bursts from our campaign, consistent with our non-detection. [ABSTRACT FROM AUTHOR]

Published
2022
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19. Preliminary sensitivity verification of the SKA-Low AAVS2 prototype

Author

Sokolowski, M., primary, Broderick, J. W., additional, Wayth, R. B., additional, Davidson, D. B., additional, Tingay, S. J., additional, Ung, D., additional, Benthem, P., additional, Bercigli, M., additional, Bolli, P., additional, Booler, T., additional, Chiello, R., additional, Comoretto, G., additional, Di Ninni, P., additional, Kovaleva, M., additional, Macario, G., additional, Magrok, A., additional, Mattana, A., additional, Monari, J., additional, Perini, F., additional, Pupillo, G., additional, Schiaffino, M., additional, Sutinjo, A., additional, van Es, A., additional, Virone, G., additional, and Waterson, M., additional

Published
2021
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24. Neural representations of haptic object size in the human brain revealed by multivoxel fMRI patterns

Author

Perini, F., Powell, T., Watt, S.J., and Downing, P.E.

Subjects
clinical article, logic, skin, adult, abrain region, lateral prefrontal cortex, intraparietal sulcus, behavioral disciplines and activities, functional magnetic resonance imaging, decision making, size estimation, human experiment, multivoxel pattern analysis, female, haptics, male, functional MRI, controlled study, human, psychological phenomena and processes
Abstract

The brain must interpret sensory input from diverse receptor systems to estimate object properties. Much has been learned about the brain mechanisms behind these processes in vision, but our understanding of haptic perception remains less clear. Here we examined haptic judgments of object size, which require integrating multiple cutaneous and proprioceptive afferent signals, as a model problem. To identify candidate human brain regions that support this process, participants (n = 16) in an event-related functional MRI experiment grasped objects to categorize them as one of four sizes. Object sizes were calibrated psychophysically to be equally distinct for each participant. We applied representational similarity logic to whole brain, multivoxel searchlight analyses to identify brain regions that exhibit size-relevant voxelwise activity patterns. Of particular interest was to identify regions for which more similar sizes produce more similar patterns of activity, which constitutes evidence of a metric size code. Regions of the intraparietal sulcus and the lateral prefrontal cortex met this criterion, both within hands and across hands. We suggest that these regions compute representations of haptic size that abstract over the specific peripheral afferent signals generated in a grasp. Results of a matched visual size task, performed by the same participants and analyzed in the same fashion, identified similar regions, indicating that these representations may be partly modality general. We consider these results with respect to perspectives on magnitude estimation in general and to computational views on perceptual signal integration.NEW & NOTEWORTHY Our understanding of the neural basis of haptics (perceiving the world through touch) remains incomplete. We used functional MRI to study human haptic judgments of object size, which require integrating multiple afferent signals. Multivoxel pattern analyses identified intraparietal and prefrontal regions that encode size haptically in a metric and hand-invariant fashion. Effector-independent haptic size estimates are useful on their own and in combination with other sensory estimates for a variety of perceptual and motor tasks.

Published
2020

28. A Southern-Hemisphere all-sky radio transient monitor for SKA-Low prototype stations

Author

Sokolowski, M., primary, Wayth, R. B., additional, Bhat, N. D. R., additional, Price, D., additional, Broderick, J. W., additional, Bernardi, G., additional, Bolli, P., additional, Chiello, R., additional, Comoretto, G., additional, Crosse, B., additional, Davidson, D. B., additional, Macario, G., additional, Magro, A., additional, Mattana, A., additional, Minchin, D., additional, McPhail, A., additional, Monari, J., additional, Perini, F., additional, Pupillo, G., additional, Sleap, G., additional, Tingay, S., additional, Ung, D., additional, and Williams, A., additional

Published
2021
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37. PyBIRALES: A Radar Data Processing Backend for the Real-Time Detection of Space Debris

Author

Cutajar, D., primary, Magro, A., additional, Borg, J., additional, Adami, K. Z., additional, Bianchi, G., additional, Pupillo, G., additional, Mattana, A., additional, Naldi, G., additional, Bortolotti, C., additional, Perini, F., additional, Lama, L., additional, Schiaffino, M., additional, Roma, M., additional, Maccaferri, A., additional, Lizia, P. Di, additional, Massari, M., additional, and Losacco, M., additional

Published
2020
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41. The State of Open Data: Histories and Horizons

Author

Davies, Tim, Walker, Stephen B, Rubinstein, M, and Perini, F

Subjects
transparency, accountability, data, open government data, open data, ddc:004
Abstract

It’s been ten years since open data first broke onto the global stage. Over the past decade, thousands of programmes and projects around the world have worked to open data and use it to address a myriad of social and economic challenges. Meanwhile, issues related to data rights and privacy have moved to the centre of public and political discourse. As the open data movement enters a new phase in its evolution, shifting to target real-world problems and embed open data thinking into other existing or emerging communities of practice, big questions still remain. How will open data initiatives respond to new concerns about privacy, inclusion, and artificial intelligence? And what can we learn from the last decade in order to deliver impact where it is most needed? The State of Open Data brings together over 60 authors from around the world to address these questions and to take stock of the real progress made to date across sectors and around the world, uncovering the issues that will shape the future of open data in the years to come., Published by African Minds and the IDRC.

Published
2019
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42. Introduction

Author

Davies, T, Walker, SB, Rubinstein, M, and Perini, F

Subjects
transparency, accountability, open government data, open data movement, open data
Abstract

Introductory chapter to the book The State of Open Data: Histories and Horizons.

Published
2019
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48. IER-SICH Nomogram to Predict Symptomatic Intracerebral Hemorrhage After Thrombectomy for Stroke

Author

Cappellari, M., Mangiafico, S., Saia, V., Pracucci, G., Nappini, S., Nencini, P., Konda, D., Sallustio, F., Vallone, S., Zini, A., Bracco, S., Tassi, R., Bergui, M., Cerrato, P., Pitrone, A., Grillo, F., Saletti, A., De Vito, A., Gasparotti, Roberto, Magoni, M., Puglielli, E., Casalena, A., Causin, F., Baracchini, C., Castellan, L., Malfatto, L., Menozzi, R., Scoditti, U., Comelli, C., Duc, E., Comai, A., Franchini, E., Cosottini, M., Mancuso, M., Peschillo, S., De Michele, M., Giorgianni, A., Delodovici, M. L., Lafe, E., Denaro, M. F., Burdi, N., Interno, S., Cavasin, N., Critelli, A., Chiumarulo, L., Petruzzellis, M., Doddi, M., Carolei, A., Auteri, W., Petrone, A., Padolecchia, R., Tassinari, T., Pavia, M., Invernizzi, P., Turcato, G., Forlivesi, S., Ciceri, E. F. M., Bonetti, B., Inzitari, D., Toni D., Limbucci N, Consoli, A, Renieri, L, Fainardi, E, Gandini, R, Pampana, E, Diomedi, M, Koch, G, Verganti, L, Sacchetti, F, Zelent, G, Bigliardi, G, Picchetto, L, Vandelli, L, Romano, Dg, Cioni, S, Gennari, P, Cerase, A, Martini, G, Stura, G, Daniele, D, Naldi, A, Papa, R, Vinci, Sl, Bernava, G, Velo, M, Caragliano, A, Tessitore, A, Buonomo, O, Musolino, R, La Spina, P, Casella, C, Carolina Fazio, M, Cotroneo, M, Onofrio, M, Azzini, C, Casetta, I, Mardighian, D, Frigerio, M, Costa, A, Di Egidio, V, Lattanzi, R, Assetta, M, Cester, G, Mavilio, N, Serrati, C, Piazza, P, Epifani, E, Andreone, A, Castellini, P, Latte, L, Grisendi, I, Vaudano, G, Comelli, S, Cavallo, R, Chianale, G, Simonetti, L, Taglialatela, F, Isceri, S, Procaccianti, G, Zaniboni, A, Borghi, A, Bonatti, G, Ferro, F, Bonatti, M, Dall'Ora, E, Currò Dossi, R, Turri, E, Turri, M, Puglioli, M, Lazzarotti, G, Lauretti, D, Giannini, N, Maccarone, M, Orlandi, G, Chiti, A, Guidetti, G, Biraschi, F, Falcou, A, Anzini, A, Mancini, A, Fausti, S, Di Mascio, Mt, Durastanti, L, Sbardella, E, Mellina, V, Baruzzi, F, Pellegrino, C, Terrana, A, Carimati, F, Ruggiero, M, Sanna, A, Passarin, Mg, Colosimo, C, Pedicelli, A, D'Argento, F, Alexandre, A, Frisullo, G, Zappoli, F, Martignoni, A, Cavallini, A, Persico, A, Valvassori, L, Piano, M, Agostoni, E, Motto, C, Gatti, A, Longoni, M, Guccione, A, Tortorella, R, Zampieri, P, Zimatore, D, Grazioli, A, Ricciardi, Gk, Augelli, R, Bovi, P, Tomelleri, G, Micheletti, N, Semeraro, V, Lucarelli, N, Ganimede, M, Tinelli, A, Pia Prontera, M, Pesare, A, Cagliari, E, Quatrale, R, Federico, F, Passalacqua, G, Filauri, P, Orlandi, B, De Santis, F, Gabriele, A, Tiseo, C, Armentano, A, Di Benedetto, O, Silvagni, U, Perrotta, P, Crispino, E, Stancati, F, Rizzuto, S, Pugliese, P, Pisani, E, Siniscalchi, A, Gaudiano, C, Pirritano, D, Del Giudice, F, Calia, S, Ganci, G, Sugo, A, Scomazzoni, F, Simionato, F, Roveri, L, De Nicola, M, Giannoni, M, Bruni, S, Gambelli, E, Provinciali, L, Carriero, A, Coppo, L, Baldan, J, Paolo Nuzzi, N, Marcheselli, S, Corato, M, Cotroneo, E, Ricciardi, F, Gigli, R, Pozzessere, C, Pezzella, Fr, Corsi, F, Squassina, G, Cobelli, M, Morassi, M, Magni, Eugenio, Pepe, F, Bigni, B, Costa, P, Crabbio, M, Griffini, S, Palmerini, F, Piras, Mp, Natrella, M, Fanelli, G, Cristoferi, M, Bottacchi, E, Corso, G, Tosi, P, Amistà, P, Russo, M, Tettoni, S, Gallesio, I, Mascolo, Mc, Meloni, Gb, Fabio, C, Maiore, M, Pintus, F, Pischedda, A, Manca, A, Mongili, C, Zanda, B, Baule, A, Pappalardo, Mp, Craparo, G, Gallo, C, Monaco, S, Mannino, M, Terruso, V, Muto, M, Guarnieri, G, Andreone, V, Dui, G, Ticca, A, Salmaggi, A, Iannucci, G, Pinna, V, Di Clemente, L, Perini, F, De Boni, A, De Luca, C, De Giorgi, F, Corraine, S, Enne, P, Ganau, C, Piras, V., Gasparotti R., Magni E (ORCID:0000-0002-2235-2280), Cappellari, M., Mangiafico, S., Saia, V., Pracucci, G., Nappini, S., Nencini, P., Konda, D., Sallustio, F., Vallone, S., Zini, A., Bracco, S., Tassi, R., Bergui, M., Cerrato, P., Pitrone, A., Grillo, F., Saletti, A., De Vito, A., Gasparotti, Roberto, Magoni, M., Puglielli, E., Casalena, A., Causin, F., Baracchini, C., Castellan, L., Malfatto, L., Menozzi, R., Scoditti, U., Comelli, C., Duc, E., Comai, A., Franchini, E., Cosottini, M., Mancuso, M., Peschillo, S., De Michele, M., Giorgianni, A., Delodovici, M. L., Lafe, E., Denaro, M. F., Burdi, N., Interno, S., Cavasin, N., Critelli, A., Chiumarulo, L., Petruzzellis, M., Doddi, M., Carolei, A., Auteri, W., Petrone, A., Padolecchia, R., Tassinari, T., Pavia, M., Invernizzi, P., Turcato, G., Forlivesi, S., Ciceri, E. F. M., Bonetti, B., Inzitari, D., Toni D., Limbucci N, Consoli, A, Renieri, L, Fainardi, E, Gandini, R, Pampana, E, Diomedi, M, Koch, G, Verganti, L, Sacchetti, F, Zelent, G, Bigliardi, G, Picchetto, L, Vandelli, L, Romano, Dg, Cioni, S, Gennari, P, Cerase, A, Martini, G, Stura, G, Daniele, D, Naldi, A, Papa, R, Vinci, Sl, Bernava, G, Velo, M, Caragliano, A, Tessitore, A, Buonomo, O, Musolino, R, La Spina, P, Casella, C, Carolina Fazio, M, Cotroneo, M, Onofrio, M, Azzini, C, Casetta, I, Mardighian, D, Frigerio, M, Costa, A, Di Egidio, V, Lattanzi, R, Assetta, M, Cester, G, Mavilio, N, Serrati, C, Piazza, P, Epifani, E, Andreone, A, Castellini, P, Latte, L, Grisendi, I, Vaudano, G, Comelli, S, Cavallo, R, Chianale, G, Simonetti, L, Taglialatela, F, Isceri, S, Procaccianti, G, Zaniboni, A, Borghi, A, Bonatti, G, Ferro, F, Bonatti, M, Dall'Ora, E, Currò Dossi, R, Turri, E, Turri, M, Puglioli, M, Lazzarotti, G, Lauretti, D, Giannini, N, Maccarone, M, Orlandi, G, Chiti, A, Guidetti, G, Biraschi, F, Falcou, A, Anzini, A, Mancini, A, Fausti, S, Di Mascio, Mt, Durastanti, L, Sbardella, E, Mellina, V, Baruzzi, F, Pellegrino, C, Terrana, A, Carimati, F, Ruggiero, M, Sanna, A, Passarin, Mg, Colosimo, C, Pedicelli, A, D'Argento, F, Alexandre, A, Frisullo, G, Zappoli, F, Martignoni, A, Cavallini, A, Persico, A, Valvassori, L, Piano, M, Agostoni, E, Motto, C, Gatti, A, Longoni, M, Guccione, A, Tortorella, R, Zampieri, P, Zimatore, D, Grazioli, A, Ricciardi, Gk, Augelli, R, Bovi, P, Tomelleri, G, Micheletti, N, Semeraro, V, Lucarelli, N, Ganimede, M, Tinelli, A, Pia Prontera, M, Pesare, A, Cagliari, E, Quatrale, R, Federico, F, Passalacqua, G, Filauri, P, Orlandi, B, De Santis, F, Gabriele, A, Tiseo, C, Armentano, A, Di Benedetto, O, Silvagni, U, Perrotta, P, Crispino, E, Stancati, F, Rizzuto, S, Pugliese, P, Pisani, E, Siniscalchi, A, Gaudiano, C, Pirritano, D, Del Giudice, F, Calia, S, Ganci, G, Sugo, A, Scomazzoni, F, Simionato, F, Roveri, L, De Nicola, M, Giannoni, M, Bruni, S, Gambelli, E, Provinciali, L, Carriero, A, Coppo, L, Baldan, J, Paolo Nuzzi, N, Marcheselli, S, Corato, M, Cotroneo, E, Ricciardi, F, Gigli, R, Pozzessere, C, Pezzella, Fr, Corsi, F, Squassina, G, Cobelli, M, Morassi, M, Magni, Eugenio, Pepe, F, Bigni, B, Costa, P, Crabbio, M, Griffini, S, Palmerini, F, Piras, Mp, Natrella, M, Fanelli, G, Cristoferi, M, Bottacchi, E, Corso, G, Tosi, P, Amistà, P, Russo, M, Tettoni, S, Gallesio, I, Mascolo, Mc, Meloni, Gb, Fabio, C, Maiore, M, Pintus, F, Pischedda, A, Manca, A, Mongili, C, Zanda, B, Baule, A, Pappalardo, Mp, Craparo, G, Gallo, C, Monaco, S, Mannino, M, Terruso, V, Muto, M, Guarnieri, G, Andreone, V, Dui, G, Ticca, A, Salmaggi, A, Iannucci, G, Pinna, V, Di Clemente, L, Perini, F, De Boni, A, De Luca, C, De Giorgi, F, Corraine, S, Enne, P, Ganau, C, Piras, V., Gasparotti R., and Magni E (ORCID:0000-0002-2235-2280)

Abstract

Background and Purpose - As a reliable scoring system to detect the risk of symptomatic intracerebral hemorrhage after thrombectomy for ischemic stroke is not yet available, we developed a nomogram for predicting symptomatic intracerebral hemorrhage in patients with large vessel occlusion in the anterior circulation who received bridging of thrombectomy with intravenous thrombolysis (training set), and to validate the model by using a cohort of patients treated with direct thrombectomy (test set). Methods - We conducted a cohort study on prospectively collected data from 3714 patients enrolled in the IER (Italian Registry of Endovascular Stroke Treatment in Acute Stroke). Symptomatic intracerebral hemorrhage was defined as any type of intracerebral hemorrhage with increase of ≥4 National Institutes of Health Stroke Scale score points from baseline ≤24 hours or death. Based on multivariate logistic models, the nomogram was generated. We assessed the discriminative performance by using the area under the receiver operating characteristic curve. Results - National Institutes of Health Stroke Scale score, onset-to-end procedure time, age, unsuccessful recanalization, and Careggi collateral score composed the IER-SICH nomogram. After removing Careggi collateral score from the first model, a second model including Alberta Stroke Program Early CT Score was developed. The area under the receiver operating characteristic curve of the IER-SICH nomogram was 0.778 in the training set (n=492) and 0.709 in the test set (n=399). The area under the receiver operating characteristic curve of the second model was 0.733 in the training set (n=988) and 0.685 in the test set (n=779). Conclusions - The IER-SICH nomogram is the first model developed and validated for predicting symptomatic intracerebral hemorrhage after thrombectomy. It may provide indications on early identification of patients for more or less postprocedural intensive management.

Published
2019

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