50 results on '"Perilhou A"'
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2. Real life condition evaluation of Inoserp PAN-AFRICA antivenom effectiveness in Cameroon.
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Jean-Philippe Chippaux, Rodrigue Ntone, David Benhammou, Yoann Madec, Gaëlle Noël, Anais Perilhou, Fai Karl, Pierre Amta, Marie Sanchez, Lucrece Matchim, Pedro Clauteaux, Lucrèce Eteki, Mark Ndifon, Yap Boum, Armand S Nkwescheu, and Fabien Taieb more...
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Arctic medicine. Tropical medicine ,RC955-962 ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundSnakebites is a serious public health issue but remains a neglected tropical disease. Data on antivenom effectiveness are urgently needed in Africa. We assessed effectiveness of Inoserp PAN-AFRICA (IPA), the recommended antivenom available in Cameroon.Methodology/principal findingsWe enrolled 447 patients presenting with snakebite in 14 health facilities across Cameroon. At presentation, cytotoxicity, coagulation troubles and neurotoxicity were graded. We administered two to four vials of antivenom to patients based on hemotoxic or neurotoxic signs. We renewed antivenom administration to patients with persistence of bleedings or neurotoxicity 2 hours after each injection. We defined early improvement as a reduction of the grade of envenomation symptoms 2 hours after first injection. Medium-term effectiveness was investigated looking at disappearance of symptoms during hospitalization. After hospital discharge, a home visit was planned to assess long-term outcomes. Between October 2019 and May 2021, we enrolled 447 (93.7%), including 72% from the savannah regions. The median [IQR] age was 25 [14-40]. Envenomation was diagnosed in 369 (82.6%) participants. The antivenom was administered to 356 patients (96.5%) of whom 256 (71.9%) received one administration. Among these patients, cytotoxic symptoms were observed in 336 (94.4%) participants, coagulation disorders in 234 (65.7%) participants and neurotoxicity in 23 (6.5%) participants. Two hours after the first administration of antivenom, we observed a decrease in coagulation disorders or neurotoxicity in 75.2% and 39.1% of patients, respectively. Complete cessation of bleedings and neurotoxicity occurred in 96% and 93% of patients within 24 hours, respectively. Sequelae have been observed in 9 (3%) patients at the home visit 15 days after hospital admission and 11 (3%) died including one before antivenom injection.Conclusions/significanceWe confirmed good effectiveness of the IPA and highlighted the rapid improvement in bleeding or neurotoxicity after the first administration. Sequential administrations of low doses of antivenom, rigorously assessed at short intervals for an eventual renewal, can preserve patient safety and save antivenom.Trial registrationNCT03326492. more...
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- 2023
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3. Snakebites in Cameroon: Tolerance of a Snake Antivenom (Inoserp™ PAN-AFRICA) in Africa in Real-Life Conditions
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David Benhammou, Jean-Philippe Chippaux, Rodrigue Ntone, Yoann Madec, Pierre Amta, Gaëlle Noel, Fai Njuwa Karl, Anaïs Perilhou, Lucrece Matchim, Marie Sanchez, Mark Ndifon, Pedro Clauteaux, Lucrèce Eteki, Yap Boum, Armand Seraphin Nkwescheu, and Fabien Taieb more...
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snakebite ,envenomation ,antivenom ,tolerance ,sub-Saharan Africa ,Cameroon ,Medicine - Abstract
Snakebite envenomation (SBE) is a public health issue in sub-Saharan countries. Antivenom is the only etiological treatment. Excellent tolerance is essential in managing SBE successfully. This study aimed to evaluate tolerance of InoserpTM PAN-AFRICA (IPA). It was conducted on fourteen sites across Cameroon. IPA was administered intravenously and repeated at the same dose every two hours if needed. Early and late tolerance was assessed by the onset of clinical signs within two hours and at a visit two weeks or more after the first IPA administration, respectively. Over 20 months, 447 patients presenting with a snakebite were included. One dose of IPA was administered to 361 patients and repeated at least once in 106 patients. No significant difference was shown between the proportion of adverse events in patients who received IPA (266/361, 73.7%) and those who did not (69/85, 81.2%) (p = 0.95). Adverse reactions, probably attributable to IPA, were identified in four (1.1%) patients, including one severe (angioedema) and three mild. All these reactions resolved favorably. None of the serious adverse events observed in twelve patients were attributed to IPA. No signs of late intolerance were observed in 302 patients. Tolerance appears to be satisfactory. The availability of effective and well-tolerated antivenoms would reduce the duration of treatment and prevent most disabilities and/or deaths. more...
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- 2024
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4. Use of herbal medicine in French Guiana: Influences and challenges for prevention strategies in the context of the COVID-19 pandemic
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Forsans, Glwadys, Tareau, Marc-alexandre, Ramiz, Leïla, Sarmento, Christelle Alves, Clément, Nathalie, Perilhou, Anaïs, Vignier, Nicolas, Odonne, Guillaume, Nacher, Mathieu, Flamand, Claude, Forsans, Glwadys, Tareau, Marc-alexandre, Ramiz, Leïla, Sarmento, Christelle Alves, Clément, Nathalie, Perilhou, Anaïs, Vignier, Nicolas, Odonne, Guillaume, Nacher, Mathieu, and Flamand, Claude more...
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Introduction In French Guiana, the COVID-19 pandemic was marked by very high levels of transmission in the population, low rates of hospitalizations and deaths and high vaccine hesitancy. The use of traditional herbal remedies is very common in the population and understanding its influence as part of the population’s healing strategy is important. We investigated the use of traditional remedies for the prevention or treatment of COVID-19 in French Guiana and its influence on vaccine hesitancy. Methods An online survey was conducted between April and May 2021 among 1,295 participants aged 18 years or older. Demographic characteristics, attitudes and perceptions of the population about the pandemic, vaccination intentions and use of traditional remedies were collected through a standardized questionnaire. The cited plants were collected and deposited at the Cayenne herbarium for identification. Results For combating COVID-19, 31.7% of people used traditional remedies while 71.4% reported usually treating themselves with remedies unrelated to COVID-19. A total of 604 use reports were recorded as "anti-coronavirus". Quassia amara (Simaroubaceae) was the most frequently used species (153/604), representing 25.3% of the citations. Preventive use was more prevalent than curative use. Vaccine hesitancy was more common among people using traditional remedies. Discussion/Conclusions Several species commonly used in French Guiana such as Quassia amara, Neurolaena lobata, Alpinia zerumbet, and Tinospora crispa were found to be used in the context of COVID-19. Further studies would be useful to investigate qualitative and quantitative components of interest, mechanisms and effects. more...
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- 2024
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5. Seroprevalence of anti-SARS-CoV-2 IgG at the first epidemic peak in French Guiana, July 2020.
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Claude Flamand, Christelle Alves Sarmento, Antoine Enfissi, Sarah Bailly, Emmanuel Beillard, Mélanie Gaillet, Céline Michaud, Véronique Servas, Nathalie Clement, Anaïs Perilhou, Thierry Carage, Didier Musso, Jean-François Carod, Stéphanie Eustache, Céline Tourbillon, Elodie Boizon, Samantha James, Félix Djossou, Henrik Salje, Simon Cauchemez, and Dominique Rousset more...
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Arctic medicine. Tropical medicine ,RC955-962 ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundWhile Latin America has been heavily affected by the pandemic, only a few seroprevalence studies have been conducted there during the first epidemic wave in the first half of 2020.Methodology/principal findingsA cross-sectional survey was performed between 15 July 2020 and 23 July 2020 among individuals who visited 4 medical laboratories or 5 health centers for routine screening or clinical management, with the exception of symptomatic suggestive cases of covid-19. Samples were screened for the presence of anti-SARS-CoV-2 IgG directed against domain S1 of the SARS-CoV-2 spike protein using the anti-SARS-CoV-2 enzyme-linked immunosorbent assay (ELISA) from Euroimmun.Conclusions/significanceThe overall seroprevalence was 15.4% [9.3%-24.4%] among 480 participants, ranging from 4.0% to 25.5% across the different municipalities. The seroprevalence did not differ according to gender (p = 0.19) or age (p = 0.51). Among SARS-CoV-2 positive individuals, we found that 24.6% [11.5%-45.2%] reported symptoms consistent with COVID-19. Our findings revealed high levels of infection across the territory but a low number of resulting deaths, which can be explained by French Guiana's young population structure. more...
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- 2021
- Full Text
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6. Real life condition evaluation of Inoserp PAN-AFRICA antivenom effectiveness in Cameroon
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Chippaux, Jean-Philippe, primary, Ntone, Rodrigue, additional, Benhammou, David, additional, Madec, Yoann, additional, Noël, Gaëlle, additional, Perilhou, Anais, additional, Karl, Fai, additional, Amta, Pierre, additional, Sanchez, Marie, additional, Matchim, Lucrece, additional, Clauteaux, Pedro, additional, Eteki, Lucrèce, additional, Ndifon, Mark, additional, Boum, Yap, additional, Nkwescheu, Armand S., additional, and Taieb, Fabien, additional more...
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- 2023
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7. Snakebites in Cameroon: Tolerance of a Snake Antivenom (Inoserp™ PAN-AFRICA) in Africa in Real-Life Conditions.
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Benhammou, David, Chippaux, Jean-Philippe, Ntone, Rodrigue, Madec, Yoann, Amta, Pierre, Noel, Gaëlle, Karl, Fai Njuwa, Perilhou, Anaïs, Matchim, Lucrece, Sanchez, Marie, Ndifon, Mark, Clauteaux, Pedro, Eteki, Lucrèce, Boum II, Yap, Nkwescheu, Armand Seraphin, and Taieb, Fabien more...
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SNAKEBITES ,ANTIVENINS ,SNAKES ,PUBLIC health - Abstract
Snakebite envenomation (SBE) is a public health issue in sub-Saharan countries. Antivenom is the only etiological treatment. Excellent tolerance is essential in managing SBE successfully. This study aimed to evaluate tolerance of Inoserp
TM PAN-AFRICA (IPA). It was conducted on fourteen sites across Cameroon. IPA was administered intravenously and repeated at the same dose every two hours if needed. Early and late tolerance was assessed by the onset of clinical signs within two hours and at a visit two weeks or more after the first IPA administration, respectively. Over 20 months, 447 patients presenting with a snakebite were included. One dose of IPA was administered to 361 patients and repeated at least once in 106 patients. No significant difference was shown between the proportion of adverse events in patients who received IPA (266/361, 73.7%) and those who did not (69/85, 81.2%) (p = 0.95). Adverse reactions, probably attributable to IPA, were identified in four (1.1%) patients, including one severe (angioedema) and three mild. All these reactions resolved favorably. None of the serious adverse events observed in twelve patients were attributed to IPA. No signs of late intolerance were observed in 302 patients. Tolerance appears to be satisfactory. The availability of effective and well-tolerated antivenoms would reduce the duration of treatment and prevent most disabilities and/or deaths. [ABSTRACT FROM AUTHOR] more...- Published
- 2024
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8. Increased Risk of Serious Bacterial Infections Due to Maternal Immunosuppression in HIV-Exposed Uninfected Infants in a European Country
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France REcherche Nord&Sud Sida-HIV Hepatites - Enquete Perinatale Francaise - C01/C011 Study Group, Taron-Brocard, Clement, Le Chenadec, Jerome, Faye, Albert, Dollfus, Catherine, Goetghebuer, Tessa, Gajdos, Vincent, Labaune, Jean-Marc, Perilhou, Anais, Mandelbrot, Laurent, Blanche, Stephane, and Warszawski, Josiane more...
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- 2014
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9. Use of Herbal Medicine in French Guiana: Influences and Challenges for Prevention Strategies in the Context of the COVID-19 Pandemic
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Glwadys Forsans, Marc-Alexandre Tareau, Leïla Ramiz, Christelle Alves Sarmento, Nathalie Clément, Anaïs Perilhou, nicolas vignier, Guillaume Odonne, Mathieu Nacher, and Claude Flamand
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- 2022
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10. Seroprevalence of anti-SARS-CoV-2 IgG at the first epidemic peak in French Guiana, July 2020
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Anais Perilhou, Elodie Boizon, Dominique Rousset, Nathalie Clement, Antoine Enfissi, Véronique Servas, Didier Musso, Thierry Carage, Félix Djossou, Céline Michaud, E. Beillard, Christelle Alves Sarmento, Stephanie Eustache, Sarah Bailly, Simon Cauchemez, Jean-François Carod, Samantha James, Mélanie Gaillet, Claude Flamand, Henrik Salje, Celine Tourbillon, Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP), Modélisation mathématique des maladies infectieuses - Mathematical modelling of Infectious Diseases, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Centre de Recherche Translationnelle - Center for Translational Science (CRT), Institut Pasteur [Paris], Laboratoire d'Analyses Médicales [Kourou], Eurofins Labazur, Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées (IRBA), Centre Hospitalier de l'Ouest Guyanais Franck Joly [Saint-Laurent-du-Maroni, Guyane Française], Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), University of Cambridge [UK] (CAM), Johns Hopkins Bloomberg School of Public Health [Baltimore], Johns Hopkins University (JHU), This study was supported by the National Research Agency to CF, the 'European Regional Development Fund' (GY0027257) to CF, the 'Regional Health Agency of French Guiana' to CF and the « URGENCE COVID-19 » fundraising campaign of Institut Pasteur to CF., Unité d'Epidémiologie [Cayenne, Guyane française], Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire de virologie [Cayenne, Guyane française], Laboratoire de biologie médicale [Cayenne, Guyane française] (LBM), Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), This study was supported by the National Research Agency to CF, the 'European Regional Development Fund' (GY0027257) to CF, the 'Regional Health Agency of French Guiana' to CF and the « URGENCE COVID-19 » fundraising campaign of Institut Pasteur to CF. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript, We are grateful to all field workers, collaborators, technical and medical staff from Health Centers Department of Cayenne Hospital Center and biological laboratories and health centers involved in the EPI-COVID-19 project. We thank Bhety LABEAU, David MOUA, Laetitia BREMAND, Sylvie ALOEPOE, Elisabeth CHAN from Institut Pasteur in French Guiana, Nathalie JOLLY from Clinical Core of the Center for Translational Research of Institut Pasteur. We also thank Sophie GAULIN, Lysiane ROMAIN, Véronique TOGNERI and Tadens MPWENE from La Liberté., ANR-20-COVI-0014,EPI-COVID-19,Étude de la transmission intra-ménage autour des cas confirmés de COVID-19 en Guyane(2020), Flamand, Claude [0000-0002-8064-445X], Beillard, Emmanuel [0000-0002-2546-7614], Michaud, Céline [0000-0001-5410-6298], Cauchemez, Simon [0000-0001-9186-4549], Apollo - University of Cambridge Repository, and Salje, Henrik [0000-0003-3626-4254] more...
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RNA viruses ,Viral Diseases ,Pulmonology ,Coronaviruses ,Physiology ,RC955-962 ,030204 cardiovascular system & hematology ,Antibodies, Viral ,Serology ,MESH: Aged, 80 and over ,Medical Conditions ,0302 clinical medicine ,Seroepidemiologic Studies ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Arctic medicine. Tropical medicine ,MESH: Child ,Pandemic ,MESH: COVID-19 ,Medicine ,030212 general & internal medicine ,[MATH]Mathematics [math] ,Enzyme-Linked Immunoassays ,Child ,Pathology and laboratory medicine ,Virus Testing ,MESH: Immunoglobulin G ,MESH: Aged ,Aged, 80 and over ,[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases ,MESH: Middle Aged ,Medical microbiology ,Middle Aged ,MESH: Infant ,French Guiana ,3. Good health ,Bioassays and Physiological Analysis ,Infectious Diseases ,Physiological Parameters ,MESH: Young Adult ,Child, Preschool ,Viruses ,Public aspects of medicine ,RA1-1270 ,SARS CoV 2 ,Pathogens ,Research Article ,Adult ,SARS coronavirus ,Adolescent ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Research and Analysis Methods ,Microbiology ,Respiratory Disorders ,Young Adult ,03 medical and health sciences ,MESH: Cross-Sectional Studies ,Diagnostic Medicine ,MESH: French Guiana ,Humans ,Seroprevalence ,MESH: SARS-CoV-2 ,Immunoassays ,Enzyme Assays ,Aged ,MESH: Adolescent ,Medicine and health sciences ,MESH: Humans ,MESH: Seroepidemiologic Studies ,Routine screening ,Biology and life sciences ,SARS-CoV-2 ,business.industry ,MESH: Child, Preschool ,Body Weight ,Organisms ,Viral pathogens ,Public Health, Environmental and Occupational Health ,COVID-19 ,Infant ,Spike Protein ,MESH: Adult ,Covid 19 ,Microbial pathogens ,Cross-Sectional Studies ,Young population ,Immunoglobulin G ,Respiratory Infections ,Immunologic Techniques ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Biochemical Analysis ,business ,MESH: Antibodies, Viral ,Demography - Abstract
Background While Latin America has been heavily affected by the pandemic, only a few seroprevalence studies have been conducted there during the first epidemic wave in the first half of 2020. Methodology/Principal findings A cross-sectional survey was performed between 15 July 2020 and 23 July 2020 among individuals who visited 4 medical laboratories or 5 health centers for routine screening or clinical management, with the exception of symptomatic suggestive cases of covid-19. Samples were screened for the presence of anti-SARS-CoV-2 IgG directed against domain S1 of the SARS-CoV-2 spike protein using the anti-SARS-CoV-2 enzyme-linked immunosorbent assay (ELISA) from Euroimmun. Conclusions/Significance The overall seroprevalence was 15.4% [9.3%-24.4%] among 480 participants, ranging from 4.0% to 25.5% across the different municipalities. The seroprevalence did not differ according to gender (p = 0.19) or age (p = 0.51). Among SARS-CoV-2 positive individuals, we found that 24.6% [11.5%-45.2%] reported symptoms consistent with COVID-19. Our findings revealed high levels of infection across the territory but a low number of resulting deaths, which can be explained by French Guiana’s young population structure., Author summary While Latin America has been heavily affected by the pandemic, only a few seroprevalence studies have been conducted there during the first epidemic wave in the first half of 2020. A cross-sectional survey was performed between 15 July 2020 and 23 July 2020 among individuals who visited 4 medical laboratories or 5 health centers for routine screening or clinical management, with the exception of symptomatic suggestive cases of covid-19. Samples were screened for the presence of anti-SARS-CoV-2 IgG using the anti-SARS-CoV-2 enzyme-linked immunosorbent assay (ELISA) from Euroimmun. The overall seroprevalence was 15.4% [9.3%-24.4%] among 480 participants, ranging from 4.0% to 25.5% across the different municipalities. The seroprevalence did not differ according to gender (p = 0.19) or age (p = 0.51). Among SARS-CoV-2 positive individuals, we found that 24.6% [11.5%-45.2%] reported symptoms consistent with COVID-19. Our findings revealed high levels of infection across the territory but a low number of resulting deaths, which can be explained by French Guiana’s young population structure. more...
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- 2021
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11. Use of Herbal Medicine in French Guiana: Influences and Challenges for Prevention Strategies in the Context of the COVID-19 Pandemic
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Forsans, Glwadys, primary, Tareau, Marc-Alexandre, additional, Ramiz, Leïla, additional, Sarmento, Christelle Alves, additional, Clément, Nathalie, additional, Perilhou, Anaïs, additional, vignier, nicolas, additional, Odonne, Guillaume, additional, Nacher, Mathieu, additional, and Flamand, Claude, additional more...
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- 2022
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12. Seroprevalence of anti-SARS-CoV-2 IgG at the first epidemic peak in French Guiana, July 2020
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Flamand, Claude, primary, Alves Sarmento, Christelle, additional, Enfissi, Antoine, additional, Bailly, Sarah, additional, Beillard, Emmanuel, additional, Gaillet, Mélanie, additional, Michaud, Céline, additional, Servas, Véronique, additional, Clement, Nathalie, additional, Perilhou, Anaïs, additional, Carage, Thierry, additional, Musso, Didier, additional, Carod, Jean-françois, additional, Eustache, Stéphanie, additional, Tourbillon, Céline, additional, Boizon, Elodie, additional, James, Samantha, additional, Djossou, Félix, additional, Salje, Henrik, additional, Cauchemez, Simon, additional, and Rousset, Dominique, additional more...
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- 2021
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13. Optimization of Arthrospira platensis (Spirulina) Growth: From Laboratory Scale to Pilot Scale
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Florian Delrue, Emilie Alaux, Lagia Moudjaoui, Clément Gaignard, Gatien Fleury, Amaury Perilhou, Pierre Richaud, Martin Petitjean, and Jean-François Sassi
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Spirulina cultivation ,iron content ,light intensity ,medium rationalization ,Fermentation industries. Beverages. Alcohol ,TP500-660 - Abstract
Arthrospira platensis (Spirulina) is the most cultivated microalga worldwide. Improving its cultivation in terms of biomass productivity, quality, or production cost could significantly impact the Spirulina industry. The objectives of this paper were defined as to contribute to this goal. Spirulina biomass productivity was investigated through medium choice. A modified Zarrouk’s medium was selected as it gave higher final dry weights and longer sustained growth than Hiri’s and Jourdan’s media. Then, in order to reduce Spirulina production cost, modified Zarrouk’s medium was rationalized by testing different dilutions. It was found that modified Zarrouk’s medium could be diluted up to five times without impacting the growth rates in a 28-days batch cultivation. Higher dry weights were even observed after 21 days of batch cultivation (1.21 g/L for 20%-modified Zarrouk’s medium in comparison to 0.84 g/L for modified Zarrouk’s medium). Iron uptake was then investigated as one of the major contributors to Spirulina nutritional quality. An increase in iron content was obtained by replacing iron sulfate by iron EDTA at a concentration of 10 mgFe/L (2.11 ± 0.13 mgFe/gbiomass for EDTA-FeNa, 3 H2O at 10 mgFe/L compared to 0.18 ± 0.13 for FeSO4,6H2O at 2 mgFe/L). Impact of light intensity on Spirulina biomass productivity was also investigated in a 2 L Photobioreactor (PBR). Specific growth rates were calculated for Photosynthetically Photon Flux Densities (PPFD) from 85 to 430 µmol/m2/s. At 430 µmol/m2/s, photoinhibition was not observed and the specific growth rate was maximum (0.12/day). Finally, a 40-day cultivation experiment was conducted in a 1000 L PBR giving a maximum daily areal productivity of 58.4 g/m2/day. A techno-economic analysis gave production cost two to 20 times higher for PBR (from 18.71 to 74.29 €/kg) than for open ponds (from 3.86 to 9.59 €/kg) depending on Spirulina productivity. more...
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- 2017
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14. Seroprevalence of anti-SARS-CoV-2 IgG at the epidemic peak in French Guiana
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Christelle Alves Sarmento, Mélanie Gaillet, Thierry Carage, Antoine Enfissi, Elodie Boizon, Véronique Servas, Celine Tourbillon, Félix Djossou, E. Beillard, Jean-François Carod, Anais Perilhou, Céline Michaud, Sarah Bailly, Stephanie Eustache, Didier Musso, Samantha James, Simon Cauchemez, Henrik Salje, Dominique Rousset, Claude Flamand, and Nathalie Clement more...
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Coronavirus disease 2019 (COVID-19) ,business.industry ,Young population ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Pandemic ,Medicine ,Spike Protein ,Seroprevalence ,business ,Demography ,Herd immunity - Abstract
BackgroundSARS-CoV-2 seroprevalence studies are crucial for clarifying dynamics in affected countries and determining the route that has already been achieved towards herd immunity. While Latin America has been heavily affected by the pandemic, only a few seroprevalence studies have been conducted there.MethodsA cross-sectional survey was performed between 15 July 2020 and 23 July 2020 in 4 medical biology laboratories and 5 health centers of French Guiana, representing a period shortly after the epidemic peak. Samples were screened for the presence of anti-SARS-CoV-2 IgG directed against domain S1 of the SARS-CoV-2 spike protein using the anti-SARS-CoV-2 enzyme-linked immunosorbent assay (ELISA) from Euroimmun.ResultsThe overall seroprevalence was 15.4% [9.3%-24.4%] among 480 participants, ranging from 4.0% to 25.5% across the different municipalities. The seroprevalence did not differ according to gender (p=0.19) or age (p=0.51). Among SARS-CoV-2 positive individuals, we found that 24.6% [11.5%-45.2%] reported symptoms consistent with COVID-19.ConclusionsOur findings revealed high levels of infection across the territory but a low number of resulting deaths, which can be explained by young population structure. more...
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- 2020
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15. Glucose-dependent regulation of NR2F2 promoter and influence of SNP-rs3743462 on whole body insulin sensitivity.
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Marie Boutant, Oscar Henrique Pereira Ramos, Cécile Lecoeur, Emmanuel Vaillant, Julien Philippe, Pili Zhang, Anaïs Perilhou, Beatriz Valcarcel, Sylvain Sebert, Mario-Ritta Jarvelin, Beverley Balkau, Donald Scott, Philippe Froguel, Martine Vaxillaire, and Mireille Vasseur-Cognet more...
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Medicine ,Science - Abstract
The Nuclear Receptor 2F2 (NR2F2/COUP-TFII) heterozygous knockout mice display low basal insulinemia and enhanced insulin sensitivity. We previously established that insulin represses NR2F2 gene expression in pancreatic β-cells. The cis-regulatory region of the NR2F2 promoter is unknown and its influence on metabolism in humans is poorly understood. The present study aimed to identify the regulatory regions that control NR2F2 gene transcription and to evaluate the effect of NR2F2 promoter variation on glucose homeostasis in humans.Regulation of the NR2F2 promoter was assessed using gene reporter assays, ChIP and gel shift experiments. The effects of variation at SNP rs3743462 in NR2F2 on quantitative metabolic traits were studied in two European prospective cohorts. We identified a minimal promoter region that down-regulates NR2F2 expression by attenuating HNF4α activation in response to high glucose concentrations. Subjects of the French DESIR population, who carried the rs3743462 T-to-C polymorphism, located in the distal glucose-responsive promoter, displayed lower basal insulin levels and lower HOMA-IR index. The C-allele at rs3743462 was associated with increased NR2F2 binding and decreased NR2F2 gene expression.The rs3743462 polymorphism affects glucose-responsive NR2F2 promoter regulation and thereby may influence whole-body insulin sensitivity, suggesting a role of NR2F2 in the control of glucose homeostasis in humans. more...
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- 2012
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16. Seroprevalence of anti-SARS-CoV-2 IgG at the epidemic peak in French Guiana
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Flamand, Claude, primary, Enfissi, Antoine, additional, Bailly, Sarah, additional, Sarmento, Christelle Alves, additional, Beillard, Emmanuel, additional, Gaillet, Mélanie, additional, Michaud, Céline, additional, Servas, Véronique, additional, Clement, Nathalie, additional, Perilhou, Anaïs, additional, Carage, Thierry, additional, Musso, Didier, additional, Carod, Jean-François, additional, Eustache, Stéphanie, additional, Tourbillon, Céline, additional, Boizon, Elodie, additional, James, Samantha, additional, Djossou, Félix, additional, Salje, Henrik, additional, Cauchemez, Simon, additional, and Rousset, Dominique, additional more...
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- 2020
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17. Essential Role of Chicken Ovalbumin Upstream Promoter-Transcription Factor II in Insulin Secretion and Insulin Sensitivity Revealed by Conditional Gene Knockout
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Bardoux, Pascale, Zhang, Pili, Flamez, Daisy, Perilhou, Anaïs, Lavin, Tiphaine Aguirre, Tanti, Jean-François, Hellemans, Karine, Gomas, Emmanuel, Godard, Cécile, Andreelli, Fabrizio, Buccheri, Maria Antonietta, Kahn, Axel, Le Marchand-Brustel, Yannick, Burcelin, Rémy, Schuit, Frans, and Vasseur-Cognet, Mireille more...
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- 2005
18. Optimization of Arthrospira platensis (Spirulina) Growth: From Laboratory Scale to Pilot Scale
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Martin Petitjean, Pierre Richaud, Amaury Perilhou, Emilie Alaux, Jean-François Sassi, Florian Delrue, Gatien Fleury, Clément Gaignard, and Lagia Moudjaoui
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0106 biological sciences ,Photoinhibition ,Serial dilution ,Biomass ,Photobioreactor ,iron content ,Plant Science ,Spirulina cultivation ,light intensity ,medium rationalization ,010501 environmental sciences ,01 natural sciences ,Biochemistry, Genetics and Molecular Biology (miscellaneous) ,chemistry.chemical_compound ,Animal science ,Botany ,0105 earth and related environmental sciences ,Spirulina (genus) ,lcsh:TP500-660 ,biology ,Chemistry ,010604 marine biology & hydrobiology ,biology.organism_classification ,lcsh:Fermentation industries. Beverages. Alcohol ,Iron sulfate ,Light intensity ,Productivity (ecology) ,Food Science - Abstract
Arthrospira platensis (Spirulina) is the most cultivated microalga worldwide. Improving its cultivation in terms of biomass productivity, quality, or production cost could significantly impact the Spirulina industry. The objectives of this paper were defined as to contribute to this goal. Spirulina biomass productivity was investigated through medium choice. A modified Zarrouk’s medium was selected as it gave higher final dry weights and longer sustained growth than Hiri’s and Jourdan’s media. Then, in order to reduce Spirulina production cost, modified Zarrouk’s medium was rationalized by testing different dilutions. It was found that modified Zarrouk’s medium could be diluted up to five times without impacting the growth rates in a 28-days batch cultivation. Higher dry weights were even observed after 21 days of batch cultivation (1.21 g/L for 20%-modified Zarrouk’s medium in comparison to 0.84 g/L for modified Zarrouk’s medium). Iron uptake was then investigated as one of the major contributors to Spirulina nutritional quality. An increase in iron content was obtained by replacing iron sulfate by iron EDTA at a concentration of 10 mgFe/L (2.11 ± 0.13 mgFe/gbiomass for EDTA-FeNa, 3 H2O at 10 mgFe/L compared to 0.18 ± 0.13 for FeSO4,6H2O at 2 mgFe/L). Impact of light intensity on Spirulina biomass productivity was also investigated in a 2 L Photobioreactor (PBR). Specific growth rates were calculated for Photosynthetically Photon Flux Densities (PPFD) from 85 to 430 µmol/m2/s. At 430 µmol/m2/s, photoinhibition was not observed and the specific growth rate was maximum (0.12/day). Finally, a 40-day cultivation experiment was conducted in a 1000 L PBR giving a maximum daily areal productivity of 58.4 g/m2/day. A techno-economic analysis gave production cost two to 20 times higher for PBR (from 18.71 to 74.29 €/kg) than for open ponds (from 3.86 to 9.59 €/kg) depending on Spirulina productivity. more...
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- 2017
19. The Transcription Factor COUP-TFII Is Negatively Regulated by Insulin and Glucose via Foxo1- and ChREBP-Controlled Pathways
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Ilham Kharroubi, Anaïs Perilhou, Mireille Vasseur-Cognet, Carole Hénique, Véronique Fauveau, Christophe Magnan, Catherine Postic, Cécile Tourrel-Cuzin, Carina Prip-Buus, Tadahiro Kitamura, Laboratoire de physiopathologie de la nutrition (LPN), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Probabilités et Modèles Aléatoires (LPMA), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Université Pierre et Marie Curie - Paris 6 (UPMC), Department of Earth and Planetary Sciences [Kobe], Kobe University, Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), and Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7) more...
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Male ,[SDV]Life Sciences [q-bio] ,medicine.medical_treatment ,Mice, Obese ,FOXO1 ,COUP Transcription Factor II ,Mice ,0302 clinical medicine ,Insulin-Secreting Cells ,Insulin receptor substrate ,Glucokinase ,Insulin Secretion ,Insulin ,ComputingMilieux_MISCELLANEOUS ,Mice, Knockout ,0303 health sciences ,biology ,Basic Helix-Loop-Helix Leucine Zipper Transcription Factors ,Forkhead Box Protein O1 ,Nuclear Proteins ,Forkhead Transcription Factors ,Articles ,3. Good health ,Insulin oscillation ,Liver ,030220 oncology & carcinogenesis ,Beta cell ,Signal Transduction ,medicine.medical_specialty ,Down-Regulation ,Cell Line ,03 medical and health sciences ,Downregulation and upregulation ,Internal medicine ,medicine ,Animals ,RNA, Messenger ,Molecular Biology ,Triglycerides ,030304 developmental biology ,Cell Biology ,Rats ,Mice, Inbred C57BL ,Insulin receptor ,Glucose ,Endocrinology ,Hepatocytes ,biology.protein ,Transcription Factors - Abstract
COUP-TFII has an important role in regulating metabolism in vivo. We showed this previously by deleting COUP-TFII from pancreatic beta cells in heterozygous mutant mice, which led to abnormal insulin secretion. Here, we report that COUP-TFII expression is reduced in the pancreas and liver of mice refed with a carbohydrate-rich diet and in the pancreas and liver of hyperinsulinemic and hyperglycemic mice. In pancreatic beta cells, COUP-TFII gene expression is repressed by secreted insulin in response to glucose through Foxo1 signaling. Ex vivo COUP-TFII reduces insulin production and secretion. Our results suggest that beta cell insulin secretion is under the control of an autocrine positive feedback loop by alleviating COUP-TFII repression. In hepatocytes, both insulin, through Foxo1, and high glucose concentrations repress COUP-TFII expression. We demonstrate that this negative glucose effect involves ChREBP expression. We propose that COUP-TFII acts in a coordinate fashion to control insulin secretion and glucose metabolism. more...
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- 2008
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20. The MODY1 Gene for Hepatocyte Nuclear Factor 4α and a Feedback Loop Control COUP-TFII Expression in Pancreatic Beta Cells
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Véronique Fauveau, Mireille Vasseur-Cognet, Donald K. Scott, Claes B. Wollheim, Ilham Kharroubi, Haiyan Wang, Anaïs Perilhou, Pili Zhang, and Cécile Tourrel-Cuzin
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Male ,Transcriptional Activation ,endocrine system ,Biology ,digestive system ,Hepatocyte Nuclear Factor 4/genetics/metabolism ,Cell Line ,COUP Transcription Factor II ,Mice ,Transactivation ,Insulin-Secreting Cells/metabolism ,Insulin-Secreting Cells ,medicine ,Animals ,Gene Regulatory Networks ,COUP Transcription Factor II/genetics/metabolism ,ddc:612 ,Promoter Regions, Genetic ,Molecular Biology ,Transcription factor ,COUP-TFII ,Pancreatic islets ,Promoter ,Articles ,Cell Biology ,Molecular biology ,Rats ,Mice, Inbred C57BL ,medicine.anatomical_structure ,Hepatocyte Nuclear Factor 4 ,Hepatocyte nuclear factor 4 ,Mutation ,PAX4 ,Beta cell - Abstract
Pancreatic islet beta cell differentiation and function are dependent upon a group of transcription factors that maintain the expression of key genes and suppress others. Knockout mice with the heterozygous deletion of the gene for chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) or the complete disruption of the gene for hepatocyte nuclear factor 4alpha (HNF4alpha) in pancreatic beta cells have similar insulin secretion defects, leading us to hypothesize that there is transcriptional cross talk between these two nuclear receptors. Here, we demonstrate specific HNF4alpha activation of a reporter plasmid containing the COUP-TFII gene promoter region in transfected pancreatic beta cells. The stable association of the endogenous HNF4alpha with a region of the COUP-TFII gene promoter that contains a direct repeat 1 (DR-1) binding site was revealed by chromatin immunoprecipitation. Mutation experiments showed that this DR-1 site is essential for HNF4alpha transactivation of COUP-TFII. The dominant negative suppression of HNF4alpha function decreased endogenous COUP-TFII expression, and the specific inactivation of COUP-TFII by small interfering RNA caused HNF4alpha mRNA levels in 832/13 INS-1 cells to decrease. This positive regulation of HNF4alpha by COUP-TFII was confirmed by the adenovirus-mediated overexpression of human COUP-TFII (hCOUP-TFII), which increased HNF4alpha mRNA levels in 832/13 INS-1 cells and in mouse pancreatic islets. Finally, hCOUP-TFII overexpression showed that there is direct COUP-TFII autorepression, as COUP-TFII occupies the proximal DR-1 binding site of its own gene in vivo. Therefore, COUP-TFII may contribute to the control of insulin secretion through the complex HNF4alpha/maturity-onset diabetes of the young 1 (MODY1) transcription factor network operating in beta cells. more...
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- 2008
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21. Optimization of Arthrospira platensis (Spirulina) Growth: From Laboratory Scale to Pilot Scale
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Delrue, Florian, primary, Alaux, Emilie, additional, Moudjaoui, Lagia, additional, Gaignard, Clément, additional, Fleury, Gatien, additional, Perilhou, Amaury, additional, Richaud, Pierre, additional, Petitjean, Martin, additional, and Sassi, Jean-François, additional more...
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- 2017
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22. Increased risk of serious bacterial infections due to maternal immunosuppression in HIV-exposed uninfected infants in a European country
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Marie Medus, Vincent Gajdos, Laure Clech, Céline Goissen, Arnaud Chalvon Demersay, Virginie Zarouk, Louis Bernard, Pierre-François Ceccaldi, René-Charles Rudigoz, Patricia Murger, Philippe Le Moine, Catherine Chirouze, Mandovi Rajguru, Ludovic Cravello, Véronique Lefevre Elbert, Luminata Shneider, Guy Leverger, Tessa Goetghebuer, Kamila Kebaili, Eliane Galiba, Claudine Touboul, Françoise Meier, Didier Tardif, Dieudoné Ekoukou, Michèle Granier, Ahmed Zakaria, Corinne Cudeville, Laurence Benoist, Emilie Piet, Emmanuelle Vintejoux, Yves Hatchuel, Christophe Michau, Jean-Luc Schmidt, Michel Françoise, Claire Briandet, Stéphane Blanche, Philippe Bailly-Salin, Anne Vanderbergh, Jeanne Sibiude, Christiane Kommé, Benoît Martha, Camille Runel-Belliard, Claire Pluchart, Imad Nahri, Vincent Jeantils, François Hervé, Isabelle Hau, Agnès Lefort, Dominique Ayral, Delphine Peretti, Stéphanie Proust, Marie Belloy, Christine Rouzioux, Arnaud Boutet, Philippe Van de Perre, Elisabeth Broustal, Cécile Hafner Mauvais, Thierry Pistone, Marie-Dominique Tabone, Hélène Dauphin, Laurent Cotte, Clement Taron-Brocard, Jean-Marie Lang, Christine Boissinot, Antoine Doumet, André Bongain, Narcisse Elenga, Geneviève Mouchnino, Anne Boutemy, Christine Cheneau, Pascale Perfezou, Pierre Frange, Mathilde Niault, Christelle Dupre, Anne Chacé, Jean-Paul Teglas, Corinne Daniel, Sophie Matheron, Severine Ansart, Martine Levine, Fabienne Caby, Marc Duval-Arnould, Isabelle Metheron, Kareen Billiemaz, Albert Faye, Didier Armangaud, Yamina Hammou, Neila Elaoun, Anne Deville, Philippe Arsac, Lydie Sanchez, Odile Luycx Vaillant, Philippe Lumbroso, Marie-Gisèle Lebrette, Norbert Winer, Elise Maurel, Ramona Abrudan, Luc De Saint Martin, Françoise Jacquier, Christian Calvez, Fabrice Monpoux, Louis Mesnard, Marie-Aude Khuong-Josses, David Rey, Isabelle Belzic, Christine Allisy, Claire Genet, Hervé Seaume, Roland Tubiana, Jacques Reynes, Pascale Nau, Gilles Blondin, Eric Lachassine, Yves Poinsignon, Cédric Arvieux, Leila Karaoui, Anaïs Perilhou, Amélie Benbara, Marine Joras, Sophie Leautez-Nainville, Sophie Ducroix-Roubert, Raghad Moalim, Pascal Bolot, Jacques Gaillat, Olivier Bollengier Stragier, Alain Devidas, Muriel Lalande, Delphine Lemercier, Jean-Pierre Brossier, Emmanuelle Boutard, Isolde Pauly-Ravelly, Marie-Françoise Le Coz, Anne Grelier, Alain Alissa, Christiane De Gennes, Jean-Luc Delassus, Emmanuel Mortier, Faiza Ajana, Ghislaine Firtion, Alain Berrebi, Rose Nguyen, Sarah Ducrocq, Jean-Marc Chamouilli, Fabienne Mazy, Maïa Banigé, Khaled Mohamed, Natacha Entz-Werle, Jacques Brouard, Germaine Bachelard, Sandrine Delmas, Anne Constanty, Véronique Reliquet, Sophie Couderc, Florence Veber, Lahcene Allal, Catherine Crenn-Hebert, Blandine Muanza, Gaelle Pinto-Cardoso, Laurent Mandelbrot, Ama Johnson, Fabienne Messaoudi, Christian Burle, Josiane Warszawski, Bénédicte Carpentier, Dominique Brault, Suzanne Braig, Pascale Fialaire, Corinne Fourcade, Elisabeth Questiaux, Véronique Chambrin, Alain Lafeuillade, Véronique Hentgen, Yves Aubrard, Anne Borgne, Sandrine-Anne Martha, Evelyne Werner, Corinne Floch-Tudal, Agnès Bourgeois Moine, Corinne Routier, Jérôme Le Chenadec, Anne Coursol, Alain Fisher, Amélie Chabrol, Cécile Winter, Cécile Brunet-Cartier, Philippe Labrune, Claudine Cayla, Françoise Mazingue, Virginie Vitrat, Cyril Clavel, Michel Segondy, Ruxandra-Oana Calin, Lise Selleret, Pierre Weinbreck, Zaitoun Abdallah Moussa, Joël Gaudelus, Gaetane Mousset, Thomas Guimard, Agnès Villemant Uludag, Emmanuelle Pannier, Brigitte Clavier, Nicole Ciraru-Vigneron, Alain Checoury, Christophe Elleau, Manuela Bonmarchand, Catherine Dollfus, Joëlle Dendale-Nguyen, Adrien May, Pierre Chevojon, Claire Hubert, Constance Borie, Marialuisa Partisani, Elie Azria, Edouard Vaucel, Erianna Bellaton Marouts, Philippe Moreau, Jean-Luc Esnault, Mahfoud Rouha, Mary-France Courcoux, Brigitte Heller-Roussin, Gilles Hittinger, Christine Rouger, Lanto Ratsimbazafy, Jean-Marc Labaune, Mohamed Abdelhadi, Brigitte Elharrar, Joëlle Tricoire, Eric David, Hassan Safwan, Karine Guimard, Bruno Carbonne, Muriel Barat, Marion Dehlinger-Paul, Stéphane Bounan, Myriam Costa, Estelle Bauville, Didier Pinquier, Valérie Garrait, Etienne Dienga, Odile Launay, Zoha Maakroun, and Dominique Salmon Ceron more...
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Microbiology (medical) ,Pediatrics ,medicine.medical_specialty ,medicine.medical_treatment ,Human immunodeficiency virus (HIV) ,HIV Infections ,Kaplan-Meier Estimate ,medicine.disease_cause ,Infant, Newborn, Diseases ,Pregnancy ,medicine ,Humans ,Pregnancy Complications, Infectious ,Retrospective Studies ,business.industry ,Proportional hazards model ,Risk of infection ,Hazard ratio ,Infant, Newborn ,Infant ,Immunosuppression ,Bacterial Infections ,medicine.disease ,Confidence interval ,Infectious Disease Transmission, Vertical ,CD4 Lymphocyte Count ,Infectious Diseases ,Immunology ,Cohort ,Female ,France ,business ,Immunosuppressive Agents - Abstract
BACKGROUND Morbidity and mortality are higher among human immunodeficiency virus (HIV) exposed but uninfected (HEU) infants than unexposed infants, particularly if the mother had a low CD4 count. We investigated the possible association between maternal immune depression during pregnancy and the risk of infection in HEU infants in the national French Perinatal Cohort (EPF). METHODS All neonates, born alive, to HIV-1-infected women enrolled in the EPF between 2002 and 2010 were included. The primary outcome was the first serious (hospitalization or death) infection during the first year of life. The main exposure variable was maternal CD4 cell count near delivery. The Kaplan-Meier method and multivariate Cox models were applied, with the different types of infections managed as competing events. RESULTS Among 7638 HEU neonates, 699 had at least 1 serious infection (of which 159 were bacterial) with a Kaplan-Meier probability of 9.3% (95% confidence interval, 8.7-10.0) at 1 year. The risk of serious bacterial infection during the first year of life significantly increased with lower maternal CD4 cell count, before and after adjustment for maternal CD4 cell count more...
- Published
- 2014
23. Glucose-dependent regulation of NR2F2 promoter and influence of SNP-rs3743462 on whole body insulin sensitivity
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Mario-Ritta Jarvelin, Donald K. Scott, Sylvain Sebert, Marie Boutant, Beatriz Valcarcel, Emmanuel Vaillant, Martine Vaxillaire, Cécile Lecoeur, Mireille Vasseur-Cognet, Oscar Henrique Pereira Ramos, Beverley Balkau, Anaïs Perilhou, Pili Zhang, J. Philippe, Philippe Froguel, and Medical Research Council (MRC) more...
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Blood Glucose ,HOMEOSTASIS ,Mouse ,IMPACT ,medicine.medical_treatment ,LOCI ,lcsh:Medicine ,NR2F2 Gene ,COUP Transcription Factor II ,Cohort Studies ,Mice ,0302 clinical medicine ,Molecular cell biology ,Endocrinology ,Insulin-Secreting Cells ,Glucose homeostasis ,Insulin ,Prospective Studies ,lcsh:Science ,Promoter Regions, Genetic ,COUP-TFII ,Regulation of gene expression ,Genetics ,Mice, Knockout ,0303 health sciences ,education.field_of_study ,Multidisciplinary ,Animal Models ,Multidisciplinary Sciences ,Hepatocyte Nuclear Factor 4 ,Regulatory sequence ,030220 oncology & carcinogenesis ,embryonic structures ,Science & Technology - Other Topics ,Medicine ,Research Article ,Signal Transduction ,EXPRESSION ,Adult ,medicine.medical_specialty ,General Science & Technology ,Population ,Molecular Sequence Data ,DNA transcription ,Biology ,Carbohydrate metabolism ,Polymorphism, Single Nucleotide ,Cell Line ,03 medical and health sciences ,Insulin resistance ,Model Organisms ,Internal medicine ,Sequence Homology, Nucleic Acid ,medicine ,Animals ,Humans ,GENOME-WIDE ASSOCIATION ,education ,030304 developmental biology ,Diabetic Endocrinology ,Science & Technology ,Base Sequence ,Population Biology ,Endocrine Physiology ,lcsh:R ,DNA ,Diabetes Mellitus Type 2 ,medicine.disease ,GENE ,Glucose ,Gene Expression Regulation ,Genetic Polymorphism ,lcsh:Q ,TYPE-2 DIABETES RISK ,Gene expression ,Insulin Resistance ,Nuclear Receptor Signaling ,Endocrine Cells ,Population Genetics ,FASTING GLUCOSE ,DESIR - Abstract
Background The Nuclear Receptor 2F2 (NR2F2/COUP-TFII) heterozygous knockout mice display low basal insulinemia and enhanced insulin sensitivity. We previously established that insulin represses NR2F2 gene expression in pancreatic β-cells. The cis-regulatory region of the NR2F2 promoter is unknown and its influence on metabolism in humans is poorly understood. The present study aimed to identify the regulatory regions that control NR2F2 gene transcription and to evaluate the effect of NR2F2 promoter variation on glucose homeostasis in humans. Methodology/Principal Findings Regulation of the NR2F2 promoter was assessed using gene reporter assays, ChIP and gel shift experiments. The effects of variation at SNP rs3743462 in NR2F2 on quantitative metabolic traits were studied in two European prospective cohorts. We identified a minimal promoter region that down-regulates NR2F2 expression by attenuating HNF4α activation in response to high glucose concentrations. Subjects of the French DESIR population, who carried the rs3743462 T-to-C polymorphism, located in the distal glucose-responsive promoter, displayed lower basal insulin levels and lower HOMA-IR index. The C-allele at rs3743462 was associated with increased NR2F2 binding and decreased NR2F2 gene expression. Conclusions/Significance The rs3743462 polymorphism affects glucose-responsive NR2F2 promoter regulation and thereby may influence whole-body insulin sensitivity, suggesting a role of NR2F2 in the control of glucose homeostasis in humans. more...
- Published
- 2012
24. Essential role of chicken ovalbumin upstream promoter-transcription factor II in insulin secretion and insulin sensitivity revealed by conditional gene knockout
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Emmanuel Gomas, Tiphaine Aguirre Lavin, Rémy Burcelin, Cécile Godard, Pascale Bardoux, Axel Kahn, Jean-François Tanti, Mireille Vasseur-Cognet, Daisy Flamez, Fabrizio Andreelli, Yannick Le Marchand-Brustel, Anaïs Perilhou, Pili Zhang, Karine Hellemans, Frans Schuit, and Maria Antoinietta Buccheri more...
- Subjects
Blood Glucose ,Leptin ,medicine.medical_specialty ,Receptors, Steroid ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Chicken ovalbumin upstream promoter-transcription factor ,Carbohydrate metabolism ,Biology ,Fatty Acids, Nonesterified ,Glucagon ,COUP Transcription Factor II ,Islets of Langerhans ,Mice ,Internal medicine ,Insulin Secretion ,Internal Medicine ,medicine ,Glucose homeostasis ,Animals ,Homeostasis ,Insulin ,COUP-TFII ,Mice, Knockout ,Glucose transporter ,Lipids ,Insulin oscillation ,Rats ,DNA-Binding Proteins ,Endocrinology ,COUP Transcription Factors ,Glucose ,Chickens ,Gene Deletion ,Transcription Factors - Abstract
Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) has been implicated in the control of blood glucose by its potent effect on expression and signaling of various nuclear receptors. To understand the role of COUP-TFII in glucose homeostasis, conditional COUP-TFII-deficient mice were generated and crossed with mice expressing Cre under the control of rat insulin II gene promoter, resulting in deletion of COUP-TFII in pancreatic β-cells. Homozygous mutants died before birth for yet undetermined reasons. Heterozygous mice appeared healthy at birth and showed normal growth and fertility. When challenged intraperitoneally, the animals had glucose intolerance associated with reduced glucose-stimulated insulin secretion. Moreover, these heterozygous mice presented a mild increase in fasting and random-fed circulating insulin levels. In accordance, islets isolated from these animals exhibited higher insulin secretion in low glucose conditions and markedly decreased glucose-stimulated insulin secretion. Their pancreata presented normal microscopic architecture and insulin content up to 16 weeks of study. Altered insulin secretion was associated with peripheral insulin resistance in whole animals. It can be concluded that COUP-TFII is a new, important regulator of glucose homeostasis and insulin sensitivity. more...
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- 2005
25. Essential role of chicken ovalbumin upstream promoter-transcription factor II in insulin secretion and insulin sensitivity revealed by conditional gene knockout
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Bardoux, P, Zhang, P, Flamez, D, Perilhou, A, Lavin, Ta, Hellemans, Karine, and Pathologic Biochemistry and Physiology
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Insulin - Abstract
Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) has been implicated in the control of blood glucose by its potent effect on expression and signaling of various nuclear receptors. To understand the role of COUP-TFII in glucose homeostasis, conditional COUP-TFII-deficient mice were generated and crossed with mice expressing Cre under the control of rat insulin II gene promoter, resulting in deletion of COUP-TFII in pancreatic beta-cells. Homozygous mutants died before birth for yet undetermined reasons. Heterozygous mice appeared healthy at birth and showed normal growth and fertility. When challenged intraperitoneally, the animals had glucose intolerance associated with reduced glucose-stimulated insulin secretion. Moreover, these heterozygous mice presented a mild increase in fasting and random-fed circulating insulin levels. In accordance, islets isolated from these animals exhibited higher insulin secretion in low glucose conditions and markedly decreased glucose-stimulated insulin secretion. Their pancreata presented normal microscopic architecture and insulin content up to 16 weeks of study. Altered insulin secretion was associated with peripheral insulin resistance in whole animals. It can be concluded that COUP-TFII is a new, important regulator of glucose homeostasis and insulin sensitivity. more...
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- 2005
26. Increased risk of serious bacterial infections due to maternal immunosuppression in HIV-exposed uninfected infants in a European country
- Author
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Taron-Brocard, Clement, Chenadec, Jerome Le, Gajdos, Vincent, Perilhou, Anais, Mandelbrot, Laurent, Warszawski, Josiane, Faye, Albert, Dollfus, Catherine, Goetghebuer, Tessa, MarcLabaune, Jean, Blanche, Stéphane, Taron-Brocard, Clement, Chenadec, Jerome Le, Gajdos, Vincent, Perilhou, Anais, Mandelbrot, Laurent, Warszawski, Josiane, Faye, Albert, Dollfus, Catherine, Goetghebuer, Tessa, MarcLabaune, Jean, and Blanche, Stéphane more...
- Abstract
Morbidity and mortality are higher among human immunodeficiency virus (HIV) exposed but uninfected (HEU) infants than unexposed infants, particularly if the mother had a low CD4 count. We investigated the possible association between maternal immune depression during pregnancy and the risk of infection in HEU infants in the national French Perinatal Cohort (EPF). Methods.All neonates, born alive, to HIV-1-infected women enrolled in the EPF between 2002 and 2010 were included. The primary outcome was the first serious (hospitalization or death) infection during the first year of life. The main exposure variable was maternal CD4 cellcount near delivery. The Kaplan-Meier method and multivariate Cox models were applied, with the different types of infections managed as competing events. Results.Among 7638 HEU neonates, 699 had at least 1 serious infection (of which 159 were bacterial) with a Kaplan-Meier probability of 9.3% (95% confidence interval, 8.7-10.0) at 1 year. The risk of serious bacterial infection during the first year of life significantly increased with lower maternal CD4 cell count, before and after adjustment for maternal CD4 cell count <350 and 350-499 CD4/mm3 (adjusted hazard ratio = 1.7 [1.2-2.6] and 1.2 [0.8-1.9], respectively; P =. 03). This association mainly concerned infections involving encapsulated bacteria (P =. 03).The risk of serious viral infection was, by contrast, independent of the mother's CD4 cellcount. Conclusions.Maternal CD4 count is significantly and specifically associated with the risk of serious infections with encapsulated bacteria in HEU infants., SCOPUS: ar.j, info:eu-repo/semantics/published more...
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- 2014
27. Le chien errant en Guadeloupe
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Perilhou, Maïlys and Ecole Nationale Vétérinaire de Toulouse - ENVT (FRANCE)
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Médecine vétérinaire et santé animal ,Fourrière ,Maladie tropicale ,Chien errant ,Zoonose ,Infection ,Parasitisme ,Guadeloupe ,SPA - Abstract
Les chiens errants se multiplient en Guadeloupe en profitant des avantages climatiques et géographiques de l'archipel. Ce climat tropical ne leur est pourtant pas toujours favorable car il favorise le développement de nombreuses pathologies infectieuses et parasitaires. D'autre part, leur prolifération représente pour l'île une source potentielle de nuisances et de zoonoses non négligeable pour ses habitants et ses touristes. La gestion des chiens errants en Guadeloupe enfin est complexe car elle fait appel à des structures identiques à celles de la métropole mais s'inscrit en contre partie dans un contexte tropical tout à fait particulier. more...
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- 2003
28. Glucose-dependent regulation of NR2F2 promoter and influence of SNP-rs3743462 on whole body insulin sensitivity
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Boutant, M, Ramos, OHP, Lecoeur, C, Vaillant, E, Philippe, J, Zhang, P, Perilhou, A, Valcarcel, B, Sebert, S, Jarvelin, MR, Balkau, B, Scott, D, Froguel, P, Vaxillaire, M, Vasseur-Cognet, M, Boutant, M, Ramos, OHP, Lecoeur, C, Vaillant, E, Philippe, J, Zhang, P, Perilhou, A, Valcarcel, B, Sebert, S, Jarvelin, MR, Balkau, B, Scott, D, Froguel, P, Vaxillaire, M, and Vasseur-Cognet, M more...
- Abstract
Background: The Nuclear Receptor 2F2 (NR2F2/COUP-TFII) heterozygous knockout mice display low basal insulinemia and enhanced insulin sensitivity. We previously established that insulin represses NR2F2 gene expression in pancreatic β-cells. The cis-regulatory region of the NR2F2 promoter is unknown and its influence on metabolism in humans is poorly understood. The present study aimed to identify the regulatory regions that control NR2F2 gene transcription and to evaluate the effect of NR2F2 promoter variation on glucose homeostasis in humans. Methodology/Principal Findings: Regulation of the NR2F2 promoter was assessed using gene reporter assays, ChIP and gel shift experiments. The effects of variation at SNP rs3743462 in NR2F2 on quantitative metabolic traits were studied in two European prospective cohorts. We identified a minimal promoter region that down-regulates NR2F2 expression by attenuating HNF4α activation in response to high glucose concentrations. Subjects of the French DESIR population, who carried the rs3743462 T-to-C polymorphism, located in the distal glucose-responsive promoter, displayed lower basal insulin levels and lower HOMA-IR index. The C-allele at rs3743462 was associated with increased NR2F2 binding and decreased NR2F2 gene expression. Conclusions/Significance: The rs3743462 polymorphism affects glucose-responsive NR2F2 promoter regulation and thereby may influence whole-body insulin sensitivity, suggesting a role of NR2F2 in the control of glucose homeostasis in humans. © 2012 Boutant et al. more...
- Published
- 2012
29. Glucose-Dependent Regulation of NR2F2 Promoter and Influence of SNP-rs3743462 on Whole Body Insulin Sensitivity
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Boutant, Marie, primary, Ramos, Oscar Henrique Pereira, additional, Lecoeur, Cécile, additional, Vaillant, Emmanuel, additional, Philippe, Julien, additional, Zhang, Pili, additional, Perilhou, Anaïs, additional, Valcarcel, Beatriz, additional, Sebert, Sylvain, additional, Jarvelin, Mario-Ritta, additional, Balkau, Beverley, additional, Scott, Donald, additional, Froguel, Philippe, additional, Vaxillaire, Martine, additional, and Vasseur-Cognet, Mireille, additional more...
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- 2012
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30. P75 Étude de la régulation et de la fonction du récepteur nucléaire COUP-TFII dans les neurones hypothalamiques
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Sabra-Makke, L., primary, Tourrel, C., additional, Perilhou, A., additional, Boutant, M., additional, Vasseur-Cognet, M., additional, and Bossard, P., additional
- Published
- 2009
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31. The Transcription Factor COUP-TFII Is Negatively Regulated by Insulin and Glucose via Foxo1- and ChREBP-Controlled Pathways
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Perilhou, Anaïs, primary, Tourrel-Cuzin, Cécile, additional, Kharroubi, Ilham, additional, Henique, Carole, additional, Fauveau, Véronique, additional, Kitamura, Tadahiro, additional, Magnan, Christophe, additional, Postic, Catherine, additional, Prip-Buus, Carina, additional, and Vasseur-Cognet, Mireille, additional more...
- Published
- 2008
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32. The MODY1 Gene for Hepatocyte Nuclear Factor 4α and a Feedback Loop Control COUP-TFII Expression in Pancreatic Beta Cells
- Author
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Perilhou, Anaïs, primary, Tourrel-Cuzin, Cécile, additional, Zhang, Pili, additional, Kharroubi, Ilham, additional, Wang, Haiyan, additional, Fauveau, Véronique, additional, Scott, Donald K., additional, Wollheim, Claes B., additional, and Vasseur-Cognet, Mireille, additional more...
- Published
- 2008
- Full Text
- View/download PDF
33. P75 Étude de la régulation et de la fonction du récepteur nucléaire COUP-TFII dans les neurones hypothalamiques
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Mireille Vasseur-Cognet, Anaïs Perilhou, C. Tourrel, Pascale Bossard, Marie Boutant, and L. Sabra-Makke
- Subjects
Endocrinology ,Endocrinology, Diabetes and Metabolism ,Internal Medicine ,General Medicine - Abstract
Introduction De nombreuses etudes montrent que l’hypothalamus est un organe implique dans le controle de l’homeostasie energetique. Toute perturbation de la detection des signaux emis par les nutriments et/ou les hormones par cet organe peut conduire en peripherie a une insulino-resistance et/ou a l’obesite. Notre equipe travaille sur le facteur de transcription Chicken Ovalbumin Upstream Promoter-Transcription Factor II (COUP-TFII). Des donnees obtenues a partir de nos differents modeles de souris transgeniques avec une specificite cellulaire de la deletion de ce gene suggerent fortement que son expression dans le systeme nerveux central pourrait etre liee au maintien d’une sensibilite peripherique a l’insuline. Resultats Par des techniques d’immunofluorescence, nous avons observe que l’expression de la proteine COUP-TFII est restreinte au noyau ventromedian de l’hypothalamus (VMN). Elle est presente dans des neurones exprimant le recepteur a la melanocortine MC4-R, cellules impliquees dans l’homeostasie energetique et co-localise avec la proteine Steroidogenic Factor 1 (SF1) un marqueur du noyau ventromedian. Afin d’etudier la fonction de ce facteur, nous generons une lignee de souris inactivee pour le gene COUP-TFII dans les neurones SF1 de l’hypothalamus. Parallelement, nous etudions la regulation de l’expression de COUP-TFII en reponse au statut nutritionnel et hormonal dans differents modeles murins. Une augmentation de l’insulinemie active in vivo l’expression des messagers COUP-TFII dans l’hypothalamus. Cependant, l’etude de sa regulation dans une lignee de cellules derivees de l’hypothalamus suggere fortement que les effets de l’insuline sur l’expression de COUP-TFII dans le VMN pourraient etre indirectement lies a une augmentation de la production locale du ligand du recepteur MC-4R. Ex vivo des experiences utilisant un agoniste du recepteur MC-4R montrent une augmentation de l’expression des messagers COUP-TFII. Nous testons les effets de cet agoniste chez la souris par des injections intra-cerebroventriculaires. Conclusion De par ces observations, COUP-TFII pourrait etre un nouvel acteur du controle central de l’homeostasie glucidique. more...
- Published
- 2009
- Full Text
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34. The Vibratory Sense.
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Perilhou, Pierre
- Published
- 1947
- Full Text
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35. Intensified tomography: enhancement of soft-tissue discrimination in conventional tomography of the brain. A comparison with computed tomography
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J R Perilhou, J R Metzger, E A Cabanis, and A G Maugis
- Subjects
medicine.diagnostic_test ,Tomography, X-Ray ,business.industry ,Brain ,Soft tissue ,Industrial computed tomography ,Computed tomography ,Image contrast ,Radiographic Image Enhancement ,Humans ,Medicine ,Superimposition ,Radiology, Nuclear Medicine and imaging ,Tomography ,Tomography, X-Ray Computed ,Nuclear medicine ,business ,Computed tomography laser mammography ,Image-guided radiation therapy - Abstract
A new technique to enhance the conventional tomographic images of soft tissues such as the brain is described. The method, called intensified tomography, optimizes the information available from conventional tomography through the use of three modifications: a specially designed filter to attenuate selectively the x-ray beam at the source to compensate for the variable shape of the skull, an improved blurring movement to reduce system artifacts, and enhanced image contrast by the superimposition of several identical images on the same film or television screen. Intensified tomography was performed in 200 patients. Ten of these tomographic images later were compared with computed tomographic (CT) scans to confirm that the ventricles could be imaged with intensified tomography. An unexpected case of lenticulocapsular calcification was also demonstrated by intensified tomography and confirmed by CT. It is proposed that intensified tomography be developed as a preliminary screening technique to be used in places where CT is not readily available. more...
- Published
- 1981
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36. Un tube transformateur d'image pour l'infrarouge moyen a couche photoconductrice et couche photoemissive juxtaposees: 'Le serval'
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J. Perilhou, H. Dormont, M. Auphan, J.J. Brissot, G. Pietri, and G.-A. Boutry
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Materials science ,General Engineering - Published
- 1963
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37. The Vibratory Sense
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Pierre Perilhou
- Subjects
Gender Studies ,Vibratory sense ,Arts and Humanities (miscellaneous) ,Vibration sense ,Acoustics ,Sensation ,Humans ,Experimental and Cognitive Psychology ,Psychology ,Vibration - Published
- 1947
- Full Text
- View/download PDF
38. Compensated X-ray attenuation in skull radiography
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E A, Cabanis, A, Maugis, J, Metzger, and J, Perilhou
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Radiographic Image Enhancement ,Skull ,Humans ,Filtration - Published
- 1979
39. [Measurement of the carotid flow by means of a flowmeter with thermal dilution]
- Author
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D, Dilenge, J, Perilhou, M, Auphan, H, Fischgold, J, Metzger, M, David, and R, Bourrée
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Carotid Arteries ,Blood Flow Velocity - Published
- 1967
40. [Carotid flowmetry simultaneous with cerebral angiography]
- Author
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M, Auphan, D, Dilenge, J, Perilhou, and J, Metzger
- Subjects
Adult ,Male ,Carotid Arteries ,Cerebrovascular Circulation ,Methods ,Humans ,Indicator Dilution Techniques ,Female ,Middle Aged ,Technology, Radiologic ,Blood Flow Velocity ,Aged ,Cerebral Angiography - Published
- 1969
41. [A new method of blood flow measurement based on the in vivo activation of blood oxygen by neutron irradiation]
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M, Auphan, J, Perilhou, and H, Spaa
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Adult ,Neutrons ,Oxygen ,Radiation Effects ,Radioisotope Dilution Technique ,Cerebrovascular Circulation ,Methods ,Humans ,Blood Flow Velocity ,Activation Analysis - Published
- 1971
42. Seroprevalence of anti-SARS-CoV-2 IgG at the first epidemic peak in French Guiana, July 2020
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Flamand, Claude, Alves Sarmento, Christelle, Enfissi, Antoine, Bailly, Sarah, Beillard, Emmanuel, Gaillet, M��lanie, Michaud, C��line, Servas, V��ronique, Clement, Nathalie, Perilhou, Ana��s, Carage, Thierry, Musso, Didier, Carod, Jean-Fran��ois, Eustache, St��phanie, Tourbillon, C��line, Boizon, Elodie, James, Samantha, Djossou, F��lix, Salje, Henrik, Cauchemez, Simon, and Rousset, Dominique more...
- Subjects
Medicine and health sciences ,Research and analysis methods ,Biology and life sciences ,3. Good health ,Research Article - Abstract
Funder: National Research Agency, Funder: Regional Health Agency of French Guiana, Funder: Institut Pasteur Urgence COVID-19 fundraising, BACKGROUND: While Latin America has been heavily affected by the pandemic, only a few seroprevalence studies have been conducted there during the first epidemic wave in the first half of 2020. METHODOLOGY/PRINCIPAL FINDINGS: A cross-sectional survey was performed between 15 July 2020 and 23 July 2020 among individuals who visited 4 medical laboratories or 5 health centers for routine screening or clinical management, with the exception of symptomatic suggestive cases of covid-19. Samples were screened for the presence of anti-SARS-CoV-2 IgG directed against domain S1 of the SARS-CoV-2 spike protein using the anti-SARS-CoV-2 enzyme-linked immunosorbent assay (ELISA) from Euroimmun. CONCLUSIONS/SIGNIFICANCE: The overall seroprevalence was 15.4% [9.3%-24.4%] among 480 participants, ranging from 4.0% to 25.5% across the different municipalities. The seroprevalence did not differ according to gender (p = 0.19) or age (p = 0.51). Among SARS-CoV-2 positive individuals, we found that 24.6% [11.5%-45.2%] reported symptoms consistent with COVID-19. Our findings revealed high levels of infection across the territory but a low number of resulting deaths, which can be explained by French Guiana's young population structure. more...
43. Seroprevalence of anti-SARS-CoV-2 IgG at the first epidemic peak in French Guiana, July 2020
- Author
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Flamand, Claude, Alves Sarmento, Christelle, Enfissi, Antoine, Bailly, Sarah, Beillard, Emmanuel, Gaillet, Mélanie, Michaud, Céline, Servas, Véronique, Clement, Nathalie, Perilhou, Anaïs, Carage, Thierry, Musso, Didier, Carod, Jean-François, Eustache, Stéphanie, Tourbillon, Céline, Boizon, Elodie, James, Samantha, Djossou, Félix, Salje, Henrik, Cauchemez, Simon, and Rousset, Dominique more...
- Subjects
Adult ,Aged, 80 and over ,Adolescent ,SARS-CoV-2 ,COVID-19 ,Infant ,Middle Aged ,Antibodies, Viral ,3. Good health ,French Guiana ,Young Adult ,Cross-Sectional Studies ,Seroepidemiologic Studies ,Child, Preschool ,Immunoglobulin G ,Humans ,Child ,Aged - Abstract
Funder: National Research Agency, Funder: Regional Health Agency of French Guiana, Funder: Institut Pasteur Urgence COVID-19 fundraising, BACKGROUND: While Latin America has been heavily affected by the pandemic, only a few seroprevalence studies have been conducted there during the first epidemic wave in the first half of 2020. METHODOLOGY/PRINCIPAL FINDINGS: A cross-sectional survey was performed between 15 July 2020 and 23 July 2020 among individuals who visited 4 medical laboratories or 5 health centers for routine screening or clinical management, with the exception of symptomatic suggestive cases of covid-19. Samples were screened for the presence of anti-SARS-CoV-2 IgG directed against domain S1 of the SARS-CoV-2 spike protein using the anti-SARS-CoV-2 enzyme-linked immunosorbent assay (ELISA) from Euroimmun. CONCLUSIONS/SIGNIFICANCE: The overall seroprevalence was 15.4% [9.3%-24.4%] among 480 participants, ranging from 4.0% to 25.5% across the different municipalities. The seroprevalence did not differ according to gender (p = 0.19) or age (p = 0.51). Among SARS-CoV-2 positive individuals, we found that 24.6% [11.5%-45.2%] reported symptoms consistent with COVID-19. Our findings revealed high levels of infection across the territory but a low number of resulting deaths, which can be explained by French Guiana's young population structure. more...
44. Intensified tomography: enhancement of soft-tissue discrimination in conventional tomography of the brain. A comparison with computed tomography.
- Author
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Perilhou, J R, primary, Metzger, J R, additional, Cabanis, E A, additional, and Maugis, A G, additional
- Published
- 1981
- Full Text
- View/download PDF
45. Device for ultrasonic examination of biological structures
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Perilhou, Jean R., primary and Coursant, Roger H., additional
- Published
- 1984
- Full Text
- View/download PDF
46. Un tube transformateur d'image pour l'infrarouge moyen a couche photoconductrice et couche photoemissive juxtaposees: “Le serval”
- Author
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Auphan, M., primary, Boutry, G.-A., additional, Brissot, J.J., additional, Dormont, H., additional, Perilhou, J., additional, and Pietri, G., additional
- Published
- 1963
- Full Text
- View/download PDF
47. LE DÉVELOPPEMENT DES COMPÉTENCES, une arme d'adaptation massive face aux transformations.
- Author
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Perilhou, Christophe
- Published
- 2020
48. Device for ultrasonic examination of biological structures
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Jean Perilhou and Roger Henri Coursant
- Subjects
Brightness ,Adder ,Transducer ,Acoustics and Ultrasonics ,Arts and Humanities (miscellaneous) ,Acoustics ,Ultrasonic sensor ,Signal ,Display device ,Mathematics - Abstract
A device for determining preferred directions in biological structures by ultrasonic examination. The device comprises an electroacoustic converter which is sub-divided into at least four sectors and which comprises transducers which are combined in groups in sectors which are diametrically situated with respect to the center. The transducers of each group are connected to the inputs of an adder. The outputs of the adders are connected to an arithmetic circuit which is adapted to form a first signal which is dependent of the sum of all signals generated by the transducers, and to form also a number of second signals which are dependent of the differences between signals generated by different transducer groups. The arithmetic circuit is connected to a display device for color images in a manner so that the first signals determines the brightness of the image, while the second signals determine the color information. more...
- Published
- 1984
- Full Text
- View/download PDF
49. Fantaisie : romantic French flute music.
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Beckett, Edward., London Festival Orchestra., Pople, Ross., Busser, Henri, 1872-1973. Andalucia; arr., Fauré, Gabriel, 1845-1924. Fantaisies, flute, piano, op. 79; arr., Godard, Benjamin, 1849-1895. Suite de trois morceaux, flute, string orchestra., Hüe, Georges Adolphe, 1858-1948. Gigue, flute, piano; arr., Hüe, Georges Adolphe, 1858-1948. Nocturnes, flute, orchestra., Périlhou, A. (Albert), 1846-1936. Ballade, flute, piano; arr., Ravel, Maurice, 1875-1937. Vocalise en forme d'habanera; arr., Saint-Saëns, Camille, 1835-1921. Odelette., Saint-Saëns, Camille, 1835-1921. Romances, flute, orchestra, op. 37,, Villette, Pierre. Complainte; arr., Widor, Charles Marie, 1844-1937. Suites, flute, piano, op. 34. Romance; arr., and Widor, Charles Marie, 1844-1937. Suites, flute, piano, op. 34. Scherzo; arr. more...
- Published
- 2000
50. Gamma-radiation tomography system
- Author
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Perilhou, J
- Published
- 1978
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