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1. Contents Vol. 152, 2010

Author

Hasan Yuksel, En-Chih Liao, Marc A. Riedl, Hirokazu Mizoguchi, Daniel Teschner, Riccardo Asero, Ajax Mercês Atta, Ulrike Körmöczi, Gen Tamura, Yuichi Ohkawara, Alberto Tedeschi, A. Martínez, Kaoru Kusama, Isao Ohno, Kyoko Futamura, Nozomu Ogihara, Massimo Cugno, Peter Steinberger, Erina Lin, İsmail Reisli, Akira Fukumoto, Winfried F. Pickl, Shuhei Fukuda, Yasushi Tomita, Motoaki Takayanagi, Esther von Stebut, Konosuke Omori, Arno Rottal, Kana Wada, Tomoko Nagai, Hirohisa Saito, I. Ibarrola, Shinobu Sakurada, Susetta Finotto, Manabu Nonaka, Manuel Sanchez-Solis, Fernanda Garcia Guerra, Mariana Menezes Pereira, Kaori Okuyama, Kenji Matsumoto, Chiharu Tabata, Mittermayer Barreto Santiago, Klaus G. Schmetterer, Fulya Tahan, Joachim H. Maxeiner, Ahmet Akcay, Yakup Canitez, Ozge Yilmaz, Toshiaki Yagi, Ömer Cevit, Fazil Orhan, Atsuko Sakanushi, Hironori Sagara, J.A. Asturias, Luis Garcia-Marcos, Hiroshi Komatsu, Kanami Orihara, M.C. Arilla, Ruby Pawankar, Sebastian Reuter, Chau-Mei Ho, Markus G. Seidel, Virginia Pérez-Fernández, Rie Tabata, Stephanie Dinges, Ichiro Sora, Maria Sanchez-Bahillo, Noriko Hashimoto, Hideaki Morita, Aysen Bingol Boz, Peri Caucig, Antonia Elena Martinez-Torres, Susanne Matthes-Martin, Nevin Uzuner, Martin D. Chapman, S. Brena, Andrew Saxon, Klaus Schwarz, Christian Taube, Semanur Kuyucu, Maria Luiza B. Sousa Atta, Chrystelle Colas, Demet Can, Jaw-Ji Tsai, and Akio Matsuda

Subjects
Immunology, Immunology and Allergy, General Medicine, Biology
Published
2010

2. Dual role of interleukin-1alpha in delayed-type hypersensitivity and airway hyperresponsiveness

Author

Joachim Maxeiner, Peri Caucig, Susetta Finotto, Sebastian Reuter, Christian Taube, Esther von Stebut, Daniel Teschner, and Stephanie Dinges

Subjects
Allergy, Neutrophils, Ovalbumin, medicine.medical_treatment, Immunology, Cell Count, Interferon-gamma, Mice, Th2 Cells, Immunopathology, Interleukin-1alpha, medicine, Immunology and Allergy, Animals, Hypersensitivity, Delayed, Interleukin 5, Mice, Inbred BALB C, business.industry, Interleukin, General Medicine, T lymphocyte, Immunoglobulin E, medicine.disease, Asthma, Eosinophils, medicine.anatomical_structure, Cytokine, Delayed hypersensitivity, Hemocyanins, Alum Compounds, Female, Interleukin-5, business, Bronchoalveolar Lavage Fluid, Respiratory tract
Abstract

Background: Using a T helper (Th)1/Th2 disease model, we previously showed that genetically determined Th development depends on dendritic cell-derived interleukin (IL)-1α. In Leishmania major infections, Th1 immunity develops if IL-1α is present during T cell priming, whereas at later time points, IL-1α worsens disease outcome. In the present study, we determined the role of IL-1α in other Th2-mediated diseases. Methods: BALB/c mice were subjected to delayed-type hypersensitivity (DTH) or ovalbumin (OVA)/alum-induced allergic asthma in the presence or absence of IL-1α. Results: In DTH, mice treated with IL-1α during sensitization with keyhole limpet hemocyanin (KLH)/alum developed decreased footpad swelling associated with elevated KLH-specific interferon-γ levels. In asthma, significantly decreased airway hypersensitivity responses (AHRs) were detected upon treatment with IL-1α during T cell priming. In contrast to control mice, IL-1α-treated mice showed reduced peribronchial inflammatory infiltrates. The bronchoalveolar lavage (BAL) fluid contained significantly decreased eosinophil numbers (approximately 50%), but 4 times more neutrophils. The BAL fluid of IL-1α-treated BALB/c exhibited reduced amounts of IL-5 and OVA-specific IgE serum levels. In contrast, IL-1α treatment at later time points after sensitization or during allergen challenge worsened AHR, had no effect on lung inflammation and BAL fluid cell composition. Furthermore, cytokine levels (IL-5, IL-13) and antigen-specific IgE were increased or unaltered under these conditions. Conclusion: Similarly to leishmaniasis, IL-1α administration during sensitization of Th2-mediated allergic reactions suppresses the course of disease by shifting the immune response towards Th1, whereas later treatments worsen disease outcome. Future studies will elucidate the therapeutic value of IL-1α in asthmatic patients.

Published
2009

4. Interleukin-2 immediate type hypersensitivity?

Author

Jürgen Knop, Peri Caucig, Susanne Lescau, Esther von Stebut, and Marcus Maurer

Subjects
Interleukin 2, Adult, Male, medicine.medical_treatment, Dermatology, Immunoglobulin E, Basophil degranulation, law.invention, law, medicine, Humans, biology, business.industry, Degranulation, Immunotherapy, Middle Aged, medicine.disease, In vitro, Immunology, biology.protein, Recombinant DNA, Interleukin-2, Female, Drug Eruptions, business, medicine.drug, Type I hypersensitivity
Abstract

Two patients with metastatic malignant melanoma developed immediate type hypersensitivity-like symptoms while being treated with recombinant interleukin-(IL-)2 immunotherapy. Both patients showed positive skin prick tests to IL-2, enhanced basophil degranulation in vitro and responded to anti-histamines, but laboratory investigations suggested an IgE-independent, pseudoallergic mast cell degranulation against IL-2.

Published
2008

5. An endogenous retrovirus derived from human melanoma cells

Author

Thomas, Muster, Andrea, Waltenberger, Andreas, Grassauer, Sonja, Hirschl, Peri, Caucig, Ingrid, Romirer, Dagmar, Födinger, Heide, Seppele, Oliver, Schanab, Christine, Magin-Lachmann, Roswitha, Löwer, Burkhard, Jansen, Hubert, Pehamberger, and Klaus, Wolff

Subjects
Skin Neoplasms, Base Sequence, Lymphatic Metastasis, Sequence Homology, Nucleic Acid, Endogenous Retroviruses, Molecular Sequence Data, Gene Products, env, Gene Products, gag, Gene Products, pol, Humans, Melanoma
Abstract

We show that human melanoma cells produce retrovirus-like particles that exhibit reverse transcriptase activity, package sequences homologous to human endogenous retrovirus K (HERV-K), and contain mature forms of the Gag and Env proteins. We also demonstrate expression of the pol gene and of Gag, Env, and Rec proteins in human melanomas and metastases but not in melanocytes or normal lymph nodes. The data suggest that expression of retroviral genes and production of retroviral particles is activated during development of melanoma.

Published
2003

6. Subject Index Vol. 152, 2010

Author

Hasan Yuksel, Atsuko Sakanushi, Erina Lin, Yakup Canitez, Ozge Yilmaz, Hirokazu Mizoguchi, Hiroshi Komatsu, Nevin Uzuner, Isao Ohno, Aysen Bingol Boz, Chiharu Tabata, Virginia Pérez-Fernández, Rie Tabata, Hironori Sagara, J.A. Asturias, Shuhei Fukuda, Peri Caucig, Demet Can, Motoaki Takayanagi, Jaw-Ji Tsai, Toshiaki Yagi, Hirohisa Saito, Maria Sanchez-Bahillo, Antonia Elena Martinez-Torres, Nozomu Ogihara, Manuel Sanchez-Solis, Mittermayer Barreto Santiago, Shinobu Sakurada, Kaoru Kusama, Akio Matsuda, Hideaki Morita, Chau-Mei Ho, Marc A. Riedl, Susanne Matthes-Martin, Akira Fukumoto, Yuichi Ohkawara, Stephanie Dinges, A. Martínez, Kyoko Futamura, En-Chih Liao, Ichiro Sora, Ajax Mercês Atta, Martin D. Chapman, S. Brena, Noriko Hashimoto, Kanami Orihara, Ahmet Akcay, M.C. Arilla, Peter Steinberger, Andrew Saxon, Winfried F. Pickl, Alberto Tedeschi, Tomoko Nagai, Klaus Schwarz, Fazil Orhan, I. Ibarrola, Mariana Menezes Pereira, Fernanda Garcia Guerra, Daniel Teschner, Susetta Finotto, Christian Taube, Massimo Cugno, Semanur Kuyucu, Klaus G. Schmetterer, Kaori Okuyama, Fulya Tahan, Ulrike Körmöczi, Ömer Cevit, Ruby Pawankar, İsmail Reisli, Markus G. Seidel, Maria Luiza B. Sousa Atta, Chrystelle Colas, Konosuke Omori, Kana Wada, Joachim H. Maxeiner, Esther von Stebut, Manabu Nonaka, Sebastian Reuter, Riccardo Asero, Kenji Matsumoto, Gen Tamura, Luis Garcia-Marcos, Yasushi Tomita, and Arno Rottal

Subjects
Index (economics), Immunology, Statistics, Immunology and Allergy, Subject (documents), General Medicine, Psychology
Published
2010

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