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26 results on '"Perfetti, Paola"'

1. The European Trauma Course: Transforming systems through training

Author

Thies, Karl-Christian, Bergmans, Elonka, Billington, Alistair, Fraga, Gustavo P., Trummer, Florian, Nasr, Ayman O., Tilsed, Jonathan, Kamaras, Georgie, Cebula, Gregorz, Protic, Alen, Khalifa, Gamal Eldin Abbas, Vänni, Ville, Alouini, Souhail, Uštar, Katja Kalan, Perfetti, Paola, Sari, Ferenc, Cimpoesu, Diana, Cassar, Mary Rose, Lott, Carsten, Blondeel, Lode, Kooij, Fabian, Neutel, Elizabete, and Verdonck, Philip

Published
2024
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3. Evaluating the performance of large language models in haematopoietic stem cell transplantation decision‐making

Author

Civettini, Ivan, primary, Zappaterra, Arianna, additional, Granelli, Bianca Maria, additional, Rindone, Giovanni, additional, Aroldi, Andrea, additional, Bonfanti, Stefano, additional, Colombo, Federica, additional, Fedele, Marilena, additional, Grillo, Giovanni, additional, Parma, Matteo, additional, Perfetti, Paola, additional, Terruzzi, Elisabetta, additional, Gambacorti‐Passerini, Carlo, additional, Ramazzotti, Daniele, additional, and Cavalca, Fabrizio, additional

Published
2023
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4. Evaluating the performance of large language models in haematopoietic stem cell transplantation decision‐making.

Author

Civettini, Ivan, Zappaterra, Arianna, Granelli, Bianca Maria, Rindone, Giovanni, Aroldi, Andrea, Bonfanti, Stefano, Colombo, Federica, Fedele, Marilena, Grillo, Giovanni, Parma, Matteo, Perfetti, Paola, Terruzzi, Elisabetta, Gambacorti‐Passerini, Carlo, Ramazzotti, Daniele, and Cavalca, Fabrizio

Subjects
LANGUAGE models, HEMATOPOIETIC stem cell transplantation, GENERATIVE pre-trained transformers, ARTIFICIAL intelligence
Abstract

Summary: In a first‐of‐its‐kind study, we assessed the capabilities of large language models (LLMs) in making complex decisions in haematopoietic stem cell transplantation. The evaluation was conducted not only for Generative Pre‐trained Transformer 4 (GPT‐4) but also conducted on other artificial intelligence models: PaLm 2 and Llama‐2. Using detailed haematological histories that include both clinical, molecular and donor data, we conducted a triple‐blind survey to compare LLMs to haematology residents. We found that residents significantly outperformed LLMs (p = 0.02), particularly in transplant eligibility assessment (p = 0.01). Our triple‐blind methodology aimed to mitigate potential biases in evaluating LLMs and revealed both their promise and limitations in deciphering complex haematological clinical scenarios. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Evaluating the performance of large language models in haematopoietic stem cell transplantation decision-making

Author

Civettini, I, Zappaterra, A, Granelli, B, Rindone, G, Aroldi, A, Bonfanti, S, Colombo, F, Fedele, M, Grillo, G, Parma, M, Perfetti, P, Terruzzi, E, Gambacorti-Passerini, C, Ramazzotti, D, Cavalca, F, Civettini, Ivan, Zappaterra, Arianna, Granelli, Bianca Maria, Rindone, Giovanni, Aroldi, Andrea, Bonfanti, Stefano, Colombo, Federica, Fedele, Marilena, Grillo, Giovanni, Parma, Matteo, Perfetti, Paola, Terruzzi, Elisabetta, Gambacorti-Passerini, Carlo, Ramazzotti, Daniele, Cavalca, Fabrizio, Civettini, I, Zappaterra, A, Granelli, B, Rindone, G, Aroldi, A, Bonfanti, S, Colombo, F, Fedele, M, Grillo, G, Parma, M, Perfetti, P, Terruzzi, E, Gambacorti-Passerini, C, Ramazzotti, D, Cavalca, F, Civettini, Ivan, Zappaterra, Arianna, Granelli, Bianca Maria, Rindone, Giovanni, Aroldi, Andrea, Bonfanti, Stefano, Colombo, Federica, Fedele, Marilena, Grillo, Giovanni, Parma, Matteo, Perfetti, Paola, Terruzzi, Elisabetta, Gambacorti-Passerini, Carlo, Ramazzotti, Daniele, and Cavalca, Fabrizio

Abstract

In a first-of-its-kind study, we assessed the capabilities of large language models (LLMs) in making complex decisions in haematopoietic stem cell transplantation. The evaluation was conducted not only for Generative Pre-trained Transformer 4 (GPT-4) but also conducted on other artificial intelligence models: PaLm 2 and Llama-2. Using detailed haematological histories that include both clinical, molecular and donor data, we conducted a triple-blind survey to compare LLMs to haematology residents. We found that residents significantly outperformed LLMs (p = 0.02), particularly in transplant eligibility assessment (p = 0.01). Our triple-blind methodology aimed to mitigate potential biases in evaluating LLMs and revealed both their promise and limitations in deciphering complex haematological clinical scenarios.

Published
2023

7. Validation of a new NGS-based myeloid panel in acute myeloid leukemia: A single-center experience

Author

Steidl, C, Aroldi, A, Mologni, L, Crespiatico, I, Fontana, D, Mastini, C, Fumagalli, M, Perfetti, P, Borin, L, Valentini, C, Piazza, R, Gambacorti-Passerini, C, Steidl, Carolina, Aroldi, Andrea, Mologni, Luca, Crespiatico, Ilaria, Fontana, Diletta, Mastini, Cristina, Fumagalli, Monica, Perfetti, Paola, Borin, Lorenza, Valentini, Claudia, Piazza, Rocco, Gambacorti-Passerini, Carlo, Steidl, C, Aroldi, A, Mologni, L, Crespiatico, I, Fontana, D, Mastini, C, Fumagalli, M, Perfetti, P, Borin, L, Valentini, C, Piazza, R, Gambacorti-Passerini, C, Steidl, Carolina, Aroldi, Andrea, Mologni, Luca, Crespiatico, Ilaria, Fontana, Diletta, Mastini, Cristina, Fumagalli, Monica, Perfetti, Paola, Borin, Lorenza, Valentini, Claudia, Piazza, Rocco, and Gambacorti-Passerini, Carlo

Abstract

Acute myeloid leukemia (AML) identifies a heterogeneous group of clonal disorders, both clinically and genetically. A large number of mutations have been described in AML, although only a few are currently employed in clinical practice. Next generation sequencing (NGS) allows for better understanding of the complex genetic background in AML and may direct individualized therapies. In this study, we aim to identify molecular aberrations that are not routinely investigated in AML using an NGS-based panel encompassing 101 genes and to evaluate how their oncogenic potential correlates with survival. Forty consecutive patients with newly diagnosed AML were enrolled between January 2018 and April 2020. We performed targeted NGS and detected 96 mutations in 36 patients (90%), while 14 fusion genes were detected in 13 patients (32%). Each mutation was weighed using OncoScore, a text-mining tool ranking genes according to their oncogenic potential. An OncoScore >= 100 was associated with shorter PFS among our patients (p = 0.05). In 11 patients with no available MRD markers at diagnosis, we were able to perform NGS-based MRD monitoring using targeted deep sequencing. Overall, our study shows that NGS is a powerful tool in AML and should be employed both in routine diagnostic workup and follow up.

Published
2022

10. Liver trauma: WSES 2020 guidelines

Author

Coccolini, Federico Coimbra, Raul Ordonez, Carlos Kluger, Yoram Vega, Felipe Moore, Ernest E. Biffl, Walt and Peitzman, Andrew Horer, Tal Abu-Zidan, Fikri M. Sartelli, Massimo Fraga, Gustavo P. Cicuttin, Enrico Ansaloni, Luca and Parra, Michael W. Millan, Mauricio DeAngelis, Nicola and Inaba, Kenji Velmahos, George Maier, Ron Khokha, Vladimir and Sakakushev, Boris Augustin, Goran di Saverio, Salomone and Pikoulis, Emanuil Chirica, Mircea Reva, Viktor Leppaniemi, Ari Manchev, Vassil Chiarugi, Massimo Damaskos, Dimitrios and Weber, Dieter Parry, Neil Demetrashvili, Zaza Civil, Ian and Napolitano, Lena Corbella, Davide Catena, Fausto and Bahouth, Hany Bahouth, Hany Tolonen, Matti Fugazzola, Paola and Serna, Jose Julian Rodriguez, Fernando Garcia, Alberto F. and Gonzalez, Adolfo Pino, Luis Fernando Guzman-Rodriguez, Monica Pereira, Bruno M. Kirkpatrick, Andrew Mefire, Alain Chichom Tarasconi, Antonio Chiara, Osvaldo Gomes, Carlos Augusto Galante, Joseph Bala, Miklosh Perfetti, Paola and Machado, Fernando Romeo, Oreste Salvetti, Francesco and Ghiadoni, Lorenzo Forfori, Francesco Malacarne, Paolo Pini, Silvia Pucciarelli, Marsia Ceresoli, Marco Arvieux, Catherine Khokha, Denis Spain, David A. Isik, Arda WSES Expert Panel

Abstract

Liver injuries represent one of the most frequent life-threatening injuries in trauma patients. In determining the optimal management strategy, the anatomic injury, the hemodynamic status, and the associated injuries should be taken into consideration. Liver trauma approach may require non-operative or operative management with the intent to restore the homeostasis and the normal physiology. The management of liver trauma should be multidisciplinary including trauma surgeons, interventional radiologists, and emergency and ICU physicians. The aim of this paper is to present the World Society of Emergency Surgery (WSES) liver trauma management guidelines.

Published
2020

13. Kidney and uro-trauma: WSES-AAST guidelines

Author

Coccolini, Federico Moore, Ernest E. Kluger, Yoram Biffl, Walter Leppaniemi, Ari Matsumura, Yosuke Kim, Fernando and Peitzman, Andrew B. Fraga, Gustavo P. Sartelli, Massimo and Ansaloni, Luca Augustin, Goran Kirkpatrick, Andrew and Abu-Zidan, Fikri Wani, Imitiaz Weber, Dieter Pikoulis, Emmanouil Larrea, Martha Arvieux, Catherine Manchev, Vassil and Reva, Viktor Coimbra, Raul Khokha, Vladimir Mefire, Alain Chichom Ordonez, Carlos Chiarugi, Massimo Machado, Fernando Sakakushev, Boris Matsumoto, Junichi Maier, Ron and di Carlo, Isidoro Catena, Fausto Fugazzola, Paola Stommel, Martijn Rajashekar, Mohan Tan, Edward Tolonen, Matti and Ceresoli, Marco Gomez, Carlos Augusto Allievi, Niccolo and Chirica, Mircea Salvetti, Francesco Bertelli, Riccardo and Ben-Ishay, Offir Bahouth, Hany Baiocchi, Gianluca Tarasconi, Antonio Cimbanassi, Stefania Chiara, Osvaldo Ten-Broek, Richard Montori, Giulia Picariello, Erika Solaini, Leonardo and Hecker, Andreas Tomasoni, Matteo Perfetti, Paola Parry, Neil DeAngelis, Nicola Pereira, Bruno M. Bado, Joaquin and Romeo, Oreste Pikoulis, Andreas Bala, Miklosh Napolitano, Lena Galante, Joseph Rizoli, Sandro Ferrada, Paula and Horer, Tal Brenner, Megan Ivatury, Rao WSES-AAST Expert Panel

Abstract

Renal and urogenital injuries occur in approximately 10-20% of abdominal trauma in adults and children. Optimal management should take into consideration the anatomic injury, the hemodynamic status, and the associated injuries. The management of urogenital trauma aims to restore homeostasis and normal physiology especially in pediatric patients where non-operative management is considered the gold standard. As with all traumatic conditions, the management of urogenital trauma should be multidisciplinary including urologists, interventional radiologists, and trauma surgeons, as well as emergency and ICU physicians. The aim of this paper is to present the World Society of Emergency Surgery (WSES) and the American Association for the Surgery of Trauma (AAST) kidney and urogenital trauma management guidelines.

Published
2019

15. A Strange Bullet

Author

Pratticò, Francesco and Perfetti, Paola

Published
2004

16. Phase II trial with sequential clofarabine and cyclophosphamide for refractory and relapsed philadelphia-negative adult acute lymphoblastic leukemia. Results of the GIMEMA LAL 1610 protocol

Author

Bassan, Renato, primary, Fumagalli, Monica, additional, Chiaretti, Sabina, additional, Audisio, Ernesta, additional, Cascavilla, Nicola, additional, Paolini, Stefania, additional, Delia, Mario, additional, Cerqui, Elisa, additional, Micò, Caterina, additional, Fabbiano, Francesco, additional, Canichella, Martina, additional, Scattolin, Anna Maria, additional, Perfetti, Paola, additional, Paoloni, Francesca, additional, Iodice, Mariangela, additional, Vitale, Antonella, additional, Della Starza, Irene, additional, Fazi, Paola, additional, Vignetti, Marco, additional, and Foà, Robin, additional

Published
2019
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17. SIE/Sies/GITMO Criteria in Elderly Patients with Acute Myeloid Leukemia (AML): Useful Also in the New Drug Era? a Multicentric Real-Life Study By the Hematological Network Rete Ematologica Lombarda (REL)

Author

Borlenghi, Erika, Masina, Lorenzo, Frigeni, Marco, Lotesoriere, Ivana, Molteni, Alfredo, Fumagalli, Monica, Riva, Marta, Zappasodi, Patrizia, Bernardi, Massimo, Fracchiolla, Nicola, Gigli, Federica, Basilico, Claudia, Pagani, Chiara, Lussana, Federico, Perfetti, Paola, Cattaneo, Chiara, Tajana, Monica, Viola, Silvia, Martini, Gianluca, Catalano, Gloria, Sciumè, Mariarita, Condorelli, Annalisa, Cela, Giselda, Rossi, Giuseppe, Tucci, Alessandra, Cairoli, Roberto, and Todisco, Elisabetta

Abstract

Introduction:In elderly acute myeloid leukemia (AML) patients (pts) the debate about the use of intensive chemotherapy (iC) as opposed to non-intensive therapy (niT) or best supportive care (BSC) is a hot topic, particularly after the introduction of venetoclax (VEN) use. Age, comorbidities, functional impairment, therapy benefits and risks, pts preferences, and AML features influence this choice. The SIE/SIES/GITMO (“fitness”) criteria (Ferrara, 2013) are a valuable and comprehensive tool, but a revalidation is needed in the light of the new treatment options.

Published
2023
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21. Validation of the SAA-102 home blood pressure monitor according to the protocols of the European Society of Hypertension, the Association for the Advancement of Medical Instrumentation and the British Society of Hypertension

Author

Zaetta, Vania, primary, Daniele, Longo, additional, Perkovic, Davor, additional, Pratticò, Francesco, additional, Barisa, Marlena, additional, Perfetti, Paola, additional, Gabrieli, Alberto, additional, Buonocore, Francesco, additional, and Winnicki, Mikolaj, additional

Published
2007
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24. Hydroxocobalamin treatment of acute cyanide poisoning from apricot kernels.

Author

Cigolini D, Ricci G, Zannoni M, Codogni R, De Luca M, Perfetti P, and Rocca G

Subjects
Adult, Female, Humans, Antidotes therapeutic use, Cyanides poisoning, Hydroxocobalamin therapeutic use, Prunus poisoning, Seeds poisoning
Abstract

Clinical experience with hydroxocobalamin in acute cyanide poisoning via ingestion remains limited. This case concerns a 35-year-old mentally ill woman who consumed more than 20 apricot kernels. Published literature suggests each kernel would have contained cyanide concentrations ranging from 0.122 to 4.09 mg/g (average 2.92 mg/g). On arrival, the woman appeared asymptomatic with a raised pulse rate and slight metabolic acidosis. Forty minutes after admission (approximately 70 min postingestion), the patient experienced headache, nausea and dyspnoea, and was hypotensive, hypoxic and tachypnoeic. Following treatment with amyl nitrite and sodium thiosulphate, her methaemoglobin level was 10%. This prompted the administration of oxygen, which evoked a slight improvement in her vital signs. Hydroxocobalamin was then administered. After 24 h, she was completely asymptomatic with normalised blood pressure and other haemodynamic parameters. This case reinforces the safety and effectiveness of hydroxocobalamin in acute cyanide poisoning by ingestion.

Published
2011
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25. Images in clinical medicine. Frey's syndrome.

Author

Prattico F and Perfetti P

Subjects
Adenoma, Pleomorphic surgery, Adult, Humans, Male, Parotid Neoplasms surgery, Sweating, Gustatory etiology, Parotid Gland surgery, Postoperative Complications diagnosis, Sweating, Gustatory diagnosis
Published
2006
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26. Corticosteroids can reverse severe imatinib-induced hepatotoxicity.

Author

Ferrero D, Pogliani EM, Rege-Cambrin G, Fava C, Mattioli G, Dellacasa C, Campa E, Perfetti P, Fumagalli M, and Boccadoro M

Subjects
Benzamides, Humans, Imatinib Mesylate, Liver drug effects, Methylprednisolone therapeutic use, Prednisone therapeutic use, Adrenal Cortex Hormones therapeutic use, Antineoplastic Agents adverse effects, Chemical and Drug Induced Liver Injury, Leukemia, Myelogenous, Chronic, BCR-ABL Positive drug therapy, Liver pathology, Liver Diseases drug therapy, Piperazines adverse effects, Pyrimidines adverse effects
Abstract

Background: Imatinib can induce severe hepatotoxicity, in 1-5% of CML patients, many of whom need permanent imatinib discontinuation., Design and Results: We report 5 CML patients who developed grade 3-4 hepatotoxicity after 2-8 months in imatinib. Different aetiologies of liver damage were ruled out and toxicity recurred in 2 patients with further attempts at low dose imatinib. In all patients prednisone or methylprednisolone at 25- 40 mg/day resolved hepatotoxicity in 3-8 weeks and allowed imatinib to be resumed at full doses. Corticosteroid were tapered off in 3-5 months without hepatotoxicity recurrence., Conclusions: Corticosteroid may avoid discontinuation for hepatotoxicity of the most effective anti-CML therapy.

Published
2006

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