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1. Attributable mortality of infections caused by carbapenem-resistant Enterobacterales: results from a prospective, multinational case-control-control matched cohorts study (EURECA)

Author

Serna, Almudena de la, Monteau, Sophie, Palomo, Virginia, Soriano, Elena, Gutierrez, David, Moreno, Elisa, Sojo-Dorado, Jesus, Morales, Isabel, Maldonado, Natalia, Santis, Lucia Valiente de, Ciezar, Antonio Plata, Ruiz Mesa, Juan Diego, Diaz, Beatriz Sobrino, Gomez, Ignacio Marquez, Camacho, Ines Perez, Cano, Angela, Frutos-Adame, Azahara, Guzman-Puche, Julia, Gracia-Ahufinger, Irene, Perez-Nadales, Elena, Torre-Gimenez, Julian, Pyrpasopoulou, Athina, Iosifidis, Elias, Chorafa, Elsa, Radovanovic, Ivana, Petrovic, Sladjana, Cvetkovi, Slavica, Melentijevic, Srdjan-Sanja, Bicmen, Can, Senol, Gunes, Tubau, Fe, Camara, Jordi, Daniel Gumucio, Victor, Bassoulis, Dimitris, Deliolanis, John, Pitiriga, Vassiliki Ch., Triarides, Nikolaos, Argiti, Efstathia, Legakis, Nikolaos J., Margarita, Kyriakidou, Gijón-Cordero, Desirée, Ruiz-Garbajosa, Patricia, Rossolini, Gian Maria, Nica, Maria, Talapan, Daniela, Medić, Deana, Prijić, Sanja Maričić, Caballero, Mireia Cantero, Ramírez, Lina M Parra, Bilgin, Hüseyin, Dalekos, George N., Stefos, Aggelos, Spyridis, Nikolaos, Michos, Athanasios, De Rosa, Francesco Giuseppe, Cavallo, Rossana, Petrosillo, Nicola, Dicaro, Antonio, Landini, Maria Paola, degli Atti, Marta Luisa Ciofi, Masanovic, Mileva, Matkovic, Dusan, Tsiodras, Sotirios, Blasi, Francesco, pasquale, Marta Di, Viscoli, Claudio, Vata, Andrei, Dorneanu, Olivia, Kapisyzi, Perlat, Vince, Adriana, Tsigou, Evdoxia, Maltezos, Efstratios, Komnos, Apostolos, Gogos, Charalampos, Franzetti, Fabio, Antonelli, Massimo, Lupse, Mihaela, Corneci, Dan, Tomescu, Dana, Georgescu, Anca, Bukarica, Ljiljana, Mitrović, Goran, Krstić, Nataša Lukić, Kurti, Arsim, Reuter, Sandra, Díaz-Pollán, Beatriz, Sabater, Julia Origüen, Muñoz, Patricia, Azap, Alpay, ancak, Banu, Sahin, Arife, Akalin, Halis, Paniagua-García, María, Bravo-Ferrer, Jose M., Pérez-Galera, Salvador, Kostyanev, Tomislav, de Kraker, Marlieke E.A., Feifel, Jan, Palacios-Baena, Zaira R., Schotsman, Joost, Cantón, Rafael, Daikos, George L., Carevic, Biljana, Dragovac, Gorana, Tan, Lionel K., Raka, Lul, Hristea, Adriana, Viale, Pierluigi, Akova, Murat, Cano, Ángela, Reguera, Jose María, Bartoloni, Alessandro, Florescu, Simin-Aysel, Benea, Serban, Asensio, Ángel, Korten, Volkan, Grundmann, Hajo, Goossens, Herman, Bonten, Marc J., Gutiérrez-Gutiérrez, Belén, and Rodríguez-Baño, Jesús

Published
2024
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2. Efficacy of ceftazidime-avibactam in solid organ transplant recipients with bloodstream infections caused by carbapenemase-producing Klebsiella pneumoniae

Author

Paul, Mical, Carratala, Jordi, Oriol, Isabel, Rodríguez-Álvarez, Regino José, Cordero, Elisa, Lepe, José Antonio, de Lucas, Esperanza Merino, Muñoz, Patricia, Fortún, Jesús, Coussement, Julien, Dewispelaere, Laurent, Eriksson, Britt Marie, van Delden, Christian, Manuel, Oriol, Clemente, Wanessa T., Strabelli, Tania Mara Varejão, Pilmis, Benoit, Roilides, Emmanuel, Ranganathan N, Iyer, Grossi, Paolo A., Soldani, Fabio, Rizzi, Marco, Tan, Ban Hock, Lowman, Warren, Gunseren, Filiz, Arslan, Hande, Tufan, Zeliha Koçak, Kazak, Esra, David, Miruna D., Steinke, Seema Mehta, Ostrander, Darin, Avery, Robin, Lease, Erika D., Pérez-Nadales, Elena, Fernández-Ruiz, Mario, Natera, Alejandra M., Gutiérrez-Gutiérrez, Belén, Mularoni, Alessandra, Russelli, Giovanna, Pierrotti, Ligia Camera, Pinheiro Freire, Maristela, Falcone, Marco, Tiseo, Giusy, Tumbarello, Mario, Raffaelli, Francesca, Abdala, Edson, Bodro, Marta, Gervasi, Elena, Fariñas, María Carmen, Seminari, Elena M., Castón, Juan José, Marín-Sanz, Juan Antonio, Gálvez-Soto, Víctor, Rana, Meenakshi M., Loeches, Belén, Martín-Dávila, Pilar, Pascual, Álvaro, Rodríguez-Baño, Jesús, Aguado, José María, Martínez-Martínez, Luis, and Torre-Cisneros, Julián

Published
2023
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3. Risk factors for infections caused by carbapenem-resistant Enterobacterales: an international matched case-control-control study (EURECA)

Author

de la Serna, Almudena, Monteau, Sophie, Palomo, Virginia, Soriano, Elena, Gutierrez, David, Moreno, Elisa, Palacios, Zaira, Morales, Isabel, Maldonado, Natalia, Ciezar, Antonio Plata, Ruiz Mesa, Juan Diego, Diaz, Beatriz Sobrino, Gomez, Ignacio Marquez, Camacho, Ines Perez, Frutos-Adame, Azahara, Guzman-Puche, Julia, Gracia-Ahufinger, Irene, Perez-Nadales, Elena, Torre-Gimenez, Julian, Pyrpasopoulou, Athina, Iosifidis, Elias, Chorafa, Elsa, Radovanovic, Ivana, Petrovic, Sladjana, Cvetkovi, Slavica, Melentijevic, Srdjan-Sanja, Bicmen, Can, Senol, Gunes, Tubau, Fe, Camara, Jordi, Gumucio, Victor Daniel, Bassoulis, Dimitris, Deliolanis, John, Pitiriga, Vassiliki Ch., Triarides, Nikolaos, Argiti, Efstathia, Legakis, Nikolaos J., Margarita, Kyriakidou, Gijón-Cordero, Desirée, Ruiz-Garbajosa, Patricia, Bartoloni, Alessandro, Rossolini, Gian Maria, Florescu, Simin-Aysel, Nica, Maria, Benea, Serban, Talapan, Daniela, Medić, Deana, Prijić, Sanja Maričić, Caballero, Mireia Cantero, Parra Ramírez, Lina M., Korten, Volkan, Bilgin, Hüseyin, Dalekos, George N., Stefos, Aggelos, Spyridis, Nikolaos, Michos, Athanasios, De Rosa, Francesco Giuseppe, Cavallo, Rossana, Petrosillo, Nicola, Dicaro, Antonio, Landini, Maria Paola, Ciofi degli Atti, Marta Luisa, Masanovic, Mileva, Matkovic, Dusan, Tsiodras, Sotirios, Blasi, Francesco, Di pasquale, Marta, Viscoli, Claudio, Vata, Andrei, Dorneanu, Olivia, Kapisyzi, Perlat, Vince, Adriana, Tsigou, Evdoxia, Maltezos, Efstratios, Komnos, Apostolos, Gogos, Charalampos, Franzetti, Fabio, Antonelli, Massimo, Lupse, Mihaela, Corneci, Dan, Tomescu, Dana, Georgescu, Anca, Bukarica, Ljiljana, Mitrović, Goran, Krstić, Nataša Lukić, Kurti, Arsim, Díaz-Pollán, Beatriz, Sabater, Julia Origüen, Muñoz, Patricia, Azap, Alpay, Sancak, Banu, Sahin, Arife, Akalin, Halis, Pérez-Galera, Salvador, Bravo-Ferrer, Jose M., Paniagua, María, Kostyanev, Tomislav, de Kraker, Marlieke E.A., Feifel, Jan, Sojo-Dorado, Jesús, Schotsman, Joost, Cantón, Rafael, Daikos, George L., Carevic, Biljana, Dragovac, Gorana, Tan, Lionel K., Raka, Lul, Hristea, Adriana, Viale, Pierluigi, Akova, Murat, Reguera, Jose María, Valiente de Santis, Lucía, Torre-Cisneros, Julián, Cano, Ángela, Roilides, Emmanuel, Radulovic, Lili, Kirakli, Cenk, Shaw, Evelyn, Falagas, Matthew E., Pintado, Vicente, Goossens, Herman, Bonten, Marc J., Gutiérrez-Gutiérrez, Belén, and Rodriguez-Baño, Jesús

Published
2023
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4. Proof‑of‑concept study to quantify changes in intestinal loads of KPC-producing Klebsiella pneumoniae in colonised patients following selective digestive decontamination with oral gentamicin

Author

Pérez-Nadales, Elena, Natera, Alejandra M., Recio-Rufíán, Manuel, Guzmán-Puche, Julia, Cano, Ángela, Frutos-Adame, Azahara, Castón, Juan José, Elías-López, Cristina, Romero-Saldaña, Manuel, López-Cerero, Lorena, Martínez-Martínez, Luis, and Torre-Cisneros, Julián

Published
2022
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5. Association between rectal colonisation by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae and mortality: a prospective, observational study

Author

Cano, Ángela, Gutiérrez-Gutiérrez, Belén, Machuca, Isabel, Torre-Giménez, Julián, Frutos-Adame, Azahara, García-Gutiérrez, Manuel, Gallo-Marín, Marina, Gracia-Ahufinger, Irene, Artacho, María J., Natera, Alejandra M., Pérez-Nadales, Elena, Castón, Juan José, Mameli, Sabrina, Gómez-Delgado, Francisco, de la Fuente, Carmen, Salcedo, Inmaculada, Rodríguez-Baño, Jesús, Martínez-Martínez, Luis, and Torre-Cisneros, Julián

Published
2022
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6. Attributable mortality of infections caused by carbapenem-resistant Enterobacterales: results from a prospective, multinational case-control-control matched cohorts study (EURECA)

Author

Paniagua-García, María, primary, Bravo-Ferrer, Jose M., additional, Pérez-Galera, Salvador, additional, Kostyanev, Tomislav, additional, de Kraker, Marlieke E.A., additional, Feifel, Jan, additional, Palacios-Baena, Zaira R., additional, Schotsman, Joost, additional, Cantón, Rafael, additional, Daikos, George L., additional, Carevic, Biljana, additional, Dragovac, Gorana, additional, Tan, Lionel K., additional, Raka, Lul, additional, Hristea, Adriana, additional, Viale, Pierluigi, additional, Akova, Murat, additional, Cano, Ángela, additional, Reguera, Jose María, additional, Bartoloni, Alessandro, additional, Florescu, Simin-Aysel, additional, Benea, Serban, additional, Bukarica, Ljiljana, additional, Asensio, Ángel, additional, Korten, Volkan, additional, Grundmann, Hajo, additional, Goossens, Herman, additional, Bonten, Marc J., additional, Gutiérrez-Gutiérrez, Belén, additional, Rodríguez-Baño, Jesús, additional, Serna, Almudena de la, additional, Monteau, Sophie, additional, Palomo, Virginia, additional, Soriano, Elena, additional, Gutierrez, David, additional, Moreno, Elisa, additional, Sojo-Dorado, Jesus, additional, Morales, Isabel, additional, Maldonado, Natalia, additional, Santis, Lucia Valiente de, additional, Ciezar, Antonio Plata, additional, Ruiz Mesa, Juan Diego, additional, Diaz, Beatriz Sobrino, additional, Gomez, Ignacio Marquez, additional, Camacho, Ines Perez, additional, Cano, Angela, additional, Frutos-Adame, Azahara, additional, Guzman-Puche, Julia, additional, Gracia-Ahufinger, Irene, additional, Perez-Nadales, Elena, additional, Torre-Gimenez, Julian, additional, Pyrpasopoulou, Athina, additional, Iosifidis, Elias, additional, Chorafa, Elsa, additional, Radovanovic, Ivana, additional, Petrovic, Sladjana, additional, Cvetkovi, Slavica, additional, Melentijevic, Srdjan-Sanja, additional, Bicmen, Can, additional, Senol, Gunes, additional, Tubau, Fe, additional, Camara, Jordi, additional, Daniel Gumucio, Victor, additional, Bassoulis, Dimitris, additional, Deliolanis, John, additional, Pitiriga, Vassiliki Ch., additional, Triarides, Nikolaos, additional, Argiti, Efstathia, additional, Legakis, Nikolaos J., additional, Margarita, Kyriakidou, additional, Gijón-Cordero, Desirée, additional, Ruiz-Garbajosa, Patricia, additional, Rossolini, Gian Maria, additional, Nica, Maria, additional, Talapan, Daniela, additional, Medić, Deana, additional, Prijić, Sanja Maričić, additional, Caballero, Mireia Cantero, additional, Ramírez, Lina M Parra, additional, Bilgin, Hüseyin, additional, Dalekos, George N., additional, Stefos, Aggelos, additional, Spyridis, Nikolaos, additional, Michos, Athanasios, additional, De Rosa, Francesco Giuseppe, additional, Cavallo, Rossana, additional, Petrosillo, Nicola, additional, Dicaro, Antonio, additional, Landini, Maria Paola, additional, degli Atti, Marta Luisa Ciofi, additional, Masanovic, Mileva, additional, Matkovic, Dusan, additional, Tsiodras, Sotirios, additional, Blasi, Francesco, additional, pasquale, Marta Di, additional, Viscoli, Claudio, additional, Vata, Andrei, additional, Dorneanu, Olivia, additional, Kapisyzi, Perlat, additional, Vince, Adriana, additional, Tsigou, Evdoxia, additional, Maltezos, Efstratios, additional, Komnos, Apostolos, additional, Gogos, Charalampos, additional, Franzetti, Fabio, additional, Antonelli, Massimo, additional, Lupse, Mihaela, additional, Corneci, Dan, additional, Tomescu, Dana, additional, Georgescu, Anca, additional, Mitrović, Goran, additional, Krstić, Nataša Lukić, additional, Kurti, Arsim, additional, Reuter, Sandra, additional, Díaz-Pollán, Beatriz, additional, Sabater, Julia Origüen, additional, Muñoz, Patricia, additional, Azap, Alpay, additional, ancak, Banu, additional, Sahin, Arife, additional, and Akalin, Halis, additional

Published
2024
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7. Invasive Fusariosis in Nonneutropenic Patients, Spain, 2000-2015

Author

Perez-Nadales, Elena, Alastruey-Izquierdo, Ana, Linares-Sicilia, Maria Jose, Soto-Debran, Juan Carlos, Abdala, Edson, Garcia-Rodriguez, Julio, Montejo, Miguel, Munoz, Patricia, Lleti, Miguel Salavert, Rezusta, Antonio, de Pipaon, Maite Ruiz Perez, Yanez, Lucrecia, Merino, Esperanza, Campos-Herrero, Maria Isolina, Costa-Mateo, Jose Maria, Fortun, Jesus, Garcia-Lozano, Tomas, Garcia-Vidal, Carolina, Fernandez-Ruiz, Mario, Sanchez-Reus, Ferran, Castro-Mendez, Carmen, Guerrero-Lozano, Inmaculada, Soler-Palacin, Pere, Aguado, Jose Maria, Martinez-Martinez, Luis, Torre-Cisneros, Julian, and Nucci, Marcio

Subjects
Neutropenia -- Complications and side effects -- Demographic aspects, Mycoses -- Diagnosis -- Risk factors -- Demographic aspects, Fusarium -- Health aspects, Health
Abstract

Invasive fusariosis (IF) is a fungal disease that mostly affects patients with hematologic malignancies or who have received hematopoietic cell transplants. These patients often have prolonged and profound neutropenia, low [...]

Published
2021
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9. Predictors of mortality in solid organ transplant recipients with bloodstream infections due to carbapenemase-producing Enterobacterales: The impact of cytomegalovirus disease and lymphopenia

Author

Pérez-Nadales, Elena, Gutiérrez-Gutiérrez, Belén, Natera, Alejandra M., Abdala, Edson, Reina Magalhães, Maira, Mularoni, Alessandra, Monaco, Francesco, Camera Pierrotti, Ligia, Pinheiro Freire, Maristela, Iyer, Ranganathan N., Mehta Steinke, Seema, Grazia Calvi, Elisa, Tumbarello, Mario, Falcone, Marco, Fernández-Ruiz, Mario, Costa-Mateo, José María, Rana, Meenakshi M., Mara Varejão Strabelli, Tania, Paul, Mical, Carmen Fariñas, María, Clemente, Wanessa Trindade, Roilides, Emmanuel, Muñoz, Patricia, Dewispelaere, Laurent, Loeches, Belén, Lowman, Warren, Hock Tan, Ban, Escudero-Sánchez, Rosa, Bodro, Marta, Antonio Grossi, Paolo, Soldani, Fabio, Gunseren, Filiz, Nestorova, Nina, Pascual, Álvaro, Martínez-Martínez, Luis, Aguado, JoséMaría, Rodríguez-Baño, Jesús, and Torre-Cisneros, Julián

Published
2020
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11. Effect of appropriate combination therapy on mortality of patients with bloodstream infections due to carbapenemase-producing Enterobacteriaceae (INCREMENT): a retrospective cohort study

Author

del Toro, M D, Gálvez, J, Falcone, M, Russo, A, Giamarellou, H, Trecarichi, E M, Losito, A R, García-Vázquez, E, Hernández, A, Gómez, J, Bou, G, Iosifidis, E, Prim, N, Navarro, F, Mirelis, B, Skiada, A, Origüen, J, Juan, R San, Fernández-Ruiz, M, Larrosa, N, Puig-Asensio, M, Cisneros, J M, Molina, J, González, V, Rucci, V, de Gopegui, E Ruiz, Marinescu, C I, Martínez-Martínez, L, Fariñas, M C, Cano, M E, Gozalo, M, Mora-Rillo, M, Francisco, C Navarro-San, Peña, C, Gómez-Zorrilla, S, Tubau, F, Tsakris, A, Zarkotou, O, Antoniadou, A, Poulakou, G, Pitout, J, Virmani, D, Torre-Cisneros, J, Guzmán-Puche, J, Helvaci, Ö, Sahin, A O, Pintado, V, Ruiz, P, Bartoletti, M, Giannella, M, Tacconelli, E, Riemenschneider, F, Calbo, E, Badia, C, Xercavins, M, Gasch, O, Fontanals, D, Jové, E, Gutiérrez-Gutiérrez, Belén, Salamanca, Elena, de Cueto, Marina, Hsueh, Po-Ren, Viale, Pierluigi, Paño-Pardo, José Ramón, Venditti, Mario, Tumbarello, Mario, Daikos, George, Cantón, Rafael, Doi, Yohei, Tuon, Felipe Francisco, Karaiskos, Ilias, Pérez-Nadales, Elena, Schwaber, Mitchell J, Azap, Özlem Kurt, Souli, Maria, Roilides, Emmanuel, Pournaras, Spyros, Akova, Murat, Pérez, Federico, Bermejo, Joaquín, Oliver, Antonio, Almela, Manel, Lowman, Warren, Almirante, Benito, Bonomo, Robert A, Carmeli, Yehuda, Paterson, David L, Pascual, Alvaro, and Rodríguez-Baño, Jesús

Published
2017
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12. In vitro and in vivo efficacy of combinations of colistin and different endolysins against clinical strains of multi-drug resistant pathogens

Author

Blasco, Lucia, Ambroa, Anton, Trastoy, Rocio, Bleriot, Ines, Moscoso, Miriam, Fernández-Garcia, Laura, Perez-Nadales, Elena, Fernández-Cuenca, Felipe, Torre-Cisneros, Julian, Oteo-Iglesias, Jesus, Oliver, Antonio, Canton, Rafael, Kidd, Tim, Navarro, Ferran, Miró, Elisenda, Pascual, Alvaro, Bou, German, Martínez-Martínez, Luis, and Tomas, Maria

Published
2020
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13. Role of IP-10 to Predict Clinical Progression and Response to IL-6 Blockade With Sarilumab in Early COVID-19 Pneumonia. A Subanalysis of the SARICOR Clinical Trial

Author

Trigo-Rodríguez, Marta, primary, Cárcel, Sheila, additional, Navas, Ana, additional, Espíndola-Gómez, Reinaldo, additional, Garrido-Gracia, José Carlos, additional, Esteban Moreno, María Ángeles, additional, León-López, Rafael, additional, Pérez-Crespo, Pedro María Martínez, additional, Alonso, Eduardo Aguilar, additional, Vinuesa, David, additional, Romero-Palacios, Alberto, additional, Pérez-Camacho, Inés, additional, Gutiérrez-Gutiérrez, Belén, additional, Martínez-Marcos, Francisco Javier, additional, Fernández-Roldán, Concepción, additional, León, Eva, additional, Caño, Alexandra Aceituno, additional, Corzo-Delgado, Juan E, additional, Perez-Nadales, Elena, additional, Riazzo, Cristina, additional, de la Fuente, Carmen, additional, Jurado, Aurora, additional, Torre-Cisneros, Julián, additional, and Merchante, Nicolás, additional

Published
2023
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14. Risk factors for infections caused by carbapenem-resistant Enterobacterales: an international matched case-control-control study (EURECA)

Author

Pérez-Galera, Salvador, primary, Bravo-Ferrer, Jose M., additional, Paniagua, María, additional, Kostyanev, Tomislav, additional, de Kraker, Marlieke E.A., additional, Feifel, Jan, additional, Sojo-Dorado, Jesús, additional, Schotsman, Joost, additional, Cantón, Rafael, additional, Daikos, George L., additional, Carevic, Biljana, additional, Dragovac, Gorana, additional, Tan, Lionel K., additional, Raka, Lul, additional, Hristea, Adriana, additional, Viale, Pierluigi, additional, Akova, Murat, additional, Reguera, Jose María, additional, Valiente de Santis, Lucía, additional, Torre-Cisneros, Julián, additional, Cano, Ángela, additional, Roilides, Emmanuel, additional, Radulovic, Lili, additional, Kirakli, Cenk, additional, Shaw, Evelyn, additional, Falagas, Matthew E., additional, Pintado, Vicente, additional, Goossens, Herman, additional, Bonten, Marc J., additional, Gutiérrez-Gutiérrez, Belén, additional, Rodriguez-Baño, Jesús, additional, de la Serna, Almudena, additional, Monteau, Sophie, additional, Palomo, Virginia, additional, Soriano, Elena, additional, Gutierrez, David, additional, Moreno, Elisa, additional, Palacios, Zaira, additional, Morales, Isabel, additional, Maldonado, Natalia, additional, Ciezar, Antonio Plata, additional, Ruiz Mesa, Juan Diego, additional, Diaz, Beatriz Sobrino, additional, Gomez, Ignacio Marquez, additional, Camacho, Ines Perez, additional, Frutos-Adame, Azahara, additional, Guzman-Puche, Julia, additional, Gracia-Ahufinger, Irene, additional, Perez-Nadales, Elena, additional, Torre-Gimenez, Julian, additional, Pyrpasopoulou, Athina, additional, Iosifidis, Elias, additional, Chorafa, Elsa, additional, Radovanovic, Ivana, additional, Petrovic, Sladjana, additional, Cvetkovi, Slavica, additional, Melentijevic, Srdjan-Sanja, additional, Bicmen, Can, additional, Senol, Gunes, additional, Tubau, Fe, additional, Camara, Jordi, additional, Gumucio, Victor Daniel, additional, Bassoulis, Dimitris, additional, Deliolanis, John, additional, Pitiriga, Vassiliki Ch., additional, Triarides, Nikolaos, additional, Argiti, Efstathia, additional, Legakis, Nikolaos J., additional, Margarita, Kyriakidou, additional, Gijón-Cordero, Desirée, additional, Ruiz-Garbajosa, Patricia, additional, Bartoloni, Alessandro, additional, Rossolini, Gian Maria, additional, Florescu, Simin-Aysel, additional, Nica, Maria, additional, Benea, Serban, additional, Talapan, Daniela, additional, Medić, Deana, additional, Prijić, Sanja Maričić, additional, Caballero, Mireia Cantero, additional, Parra Ramírez, Lina M., additional, Korten, Volkan, additional, Bilgin, Hüseyin, additional, Dalekos, George N., additional, Stefos, Aggelos, additional, Spyridis, Nikolaos, additional, Michos, Athanasios, additional, De Rosa, Francesco Giuseppe, additional, Cavallo, Rossana, additional, Petrosillo, Nicola, additional, Dicaro, Antonio, additional, Landini, Maria Paola, additional, Ciofi degli Atti, Marta Luisa, additional, Masanovic, Mileva, additional, Matkovic, Dusan, additional, Tsiodras, Sotirios, additional, Blasi, Francesco, additional, Di pasquale, Marta, additional, Viscoli, Claudio, additional, Vata, Andrei, additional, Dorneanu, Olivia, additional, Kapisyzi, Perlat, additional, Vince, Adriana, additional, Tsigou, Evdoxia, additional, Maltezos, Efstratios, additional, Komnos, Apostolos, additional, Gogos, Charalampos, additional, Franzetti, Fabio, additional, Antonelli, Massimo, additional, Lupse, Mihaela, additional, Corneci, Dan, additional, Tomescu, Dana, additional, Georgescu, Anca, additional, Bukarica, Ljiljana, additional, Mitrović, Goran, additional, Krstić, Nataša Lukić, additional, Kurti, Arsim, additional, Díaz-Pollán, Beatriz, additional, Sabater, Julia Origüen, additional, Muñoz, Patricia, additional, Azap, Alpay, additional, Sancak, Banu, additional, Sahin, Arife, additional, and Akalin, Halis, additional

Published
2023
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17. Propensity Score and Desirability of Outcome Ranking Analysis of Ertapenem for Treatment of Nonsevere Bacteremic Urinary Tract Infections Due to Extended-Spectrum-Beta-Lactamase-Producing Enterobacterales in Kidney Transplant Recipients

Author

Gutierrez-Gutierrez, Belen, Perez-Nadales, Elena, Perez-Galera, Salvador, Fernandez-Ruiz, Mario, Carratala, Jordi, Oriol, Isabel, Cordero, Elisa, Antonio Lepe, Jose, Tan, Ban Hock, Corbella, Laura, Paul, Mical, Natera, Alejandra M., David, Miruna D., Montejo, Miguel, Iyer, Ranganathan N., Pierrotti, Ligia Camera, Merino, Esperanza, Steinke, Seema Mehta, Rana, Meenakshi M., Munoz, Patricia, Mularoni, Alessandra, van Delden, Christian, Grossi, Paolo Antonio, Seminari, Elena Maria, Gunseren, Filiz, Lease, Erika D., Roilides, Emmanuel, Fortun, Jesus, Arslan, Hande, Coussement, Julien, Tufan, Zeliha Kocak, Pilmis, Benoit, Rizzi, Marco, Loeches, Belen, Eriksson, Britt-Marie, Abdala, Edson, Soldani, Fabio, Lowman, Warren, Clemente, Wanessa Trindade, Bodro, Marta, Carmen Farinas, Maria, Kazak, Esra, Martinez-Martinez, Luis, Maria Aguado, Jose, Torre-Cisneros, Julian, Pascual, Alvaro, Rodriguez-Bano, Jesus, Gutierrez-Gutierrez, Belen, Perez-Nadales, Elena, Perez-Galera, Salvador, Fernandez-Ruiz, Mario, Carratala, Jordi, Oriol, Isabel, Cordero, Elisa, Antonio Lepe, Jose, Tan, Ban Hock, Corbella, Laura, Paul, Mical, Natera, Alejandra M., David, Miruna D., Montejo, Miguel, Iyer, Ranganathan N., Pierrotti, Ligia Camera, Merino, Esperanza, Steinke, Seema Mehta, Rana, Meenakshi M., Munoz, Patricia, Mularoni, Alessandra, van Delden, Christian, Grossi, Paolo Antonio, Seminari, Elena Maria, Gunseren, Filiz, Lease, Erika D., Roilides, Emmanuel, Fortun, Jesus, Arslan, Hande, Coussement, Julien, Tufan, Zeliha Kocak, Pilmis, Benoit, Rizzi, Marco, Loeches, Belen, Eriksson, Britt-Marie, Abdala, Edson, Soldani, Fabio, Lowman, Warren, Clemente, Wanessa Trindade, Bodro, Marta, Carmen Farinas, Maria, Kazak, Esra, Martinez-Martinez, Luis, Maria Aguado, Jose, Torre-Cisneros, Julian, Pascual, Alvaro, and Rodriguez-Bano, Jesus

Abstract

There are scarce data on the efficacy of ertapenem in the treatment of bacteremia due to extended-spectrum-beta-lactamase (ESBL)-producing Enterobacterales (ESBL-E) in kidney transplant (KT) recipients. We evaluated the association between treatment with ertapenem or meropenem and clinical cure in KT recipients with nonsevere bacteremic urinary tract infections (B-UTI) caused by ESBL-E. We performed a registered, retrospective, international (29 centers in 14 countries) cohort study (INCREMENT-SOT, NCT02852902). The association between targeted therapy with ertapenem versus meropenem and clinical cure at day 14 (the principal outcome) was studied by logistic regression. Propensity score matching and desirability of outcome ranking (DOOR) analyses were also performed. A total of 201 patients were included; only 1 patient (treated with meropenem) in the cohort died. Clinical cure at day 14 was reached in 45/100 (45%) and 51/101 (50.5%) of patients treated with ertapenem and meropenem, respectively (adjusted OR 1.29; 95% CI 0.51 to 3.22; P = 0.76); the propensity score-matched cohort included 55 pairs (adjusted OR for clinical cure at day 14, 1.18; 95% CI 0.43 to 3.29; P = 0.74). In this cohort, the proportion of cases treated with ertapenem with better DOOR than with meropenem was 49.7% (95% CI, 40.4 to 59.1%) when hospital stay was considered. It ranged from 59 to 67% in different scenarios of a modified (weights-based) DOOR sensitivity analysis when potential ecological advantage or cost was considered in addition to outcome. In conclusion, targeted therapy with ertapenem appears as effective as meropenem to treat nonsevere B-UTI due to ESBL-E in KT recipients and may have some advantages.

Published
2021
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18. Efficacy of beta-lactam/beta-lactamase inhibitors to treat extended-spectrum beta-lactamase-producing Enterobacterales bacteremia secondary to urinary tract infection in kidney transplant recipients (INCREMENT-SOT Project)

Author

Pierrotti, Ligia C., Perez-Nadales, Elena, Fernandez-Ruiz, Mario, Gutierrez-Gutierrez, Belen, Hock Tan, Ban, Carratala, Jordi, Oriol, Isabel, Paul, Mical, Cohen-Sinai, Noa, Lopez-Medrano, Francisco, San-Juan, Rafael, Montejo, Miguel, Freire, Maristela P., Cordero, Elisa, David, Miruna D., Merino, Esperanza, Mehta Steinke, Seema, Grossi, Paolo A., Cano, Angela, Seminari, Elena M., Valerio, Maricela, Gunseren, Filiz, Rana, Meenakshi, Mularoni, Alessandra, Martin-Davila, Pilar, van Delden, Christian, Hamiyet Demirkaya, Melike, Kocak Tufan, Zeliha, Loeches, Belen, Iyer, Ranganathan N., Soldani, Fabio, Eriksson, Britt-Marie, Pilmis, Benoit, Rizzi, Marco, Coussement, Julien, Clemente, Wanessa T., Roilides, Emmanuel, Pascual, Alvaro, Martinez-Martinez, Luis, Rodriguez-Bano, Jesus, Torre-Cisneros, Julian, Maria Aguado, Jose, Pierrotti, Ligia C., Perez-Nadales, Elena, Fernandez-Ruiz, Mario, Gutierrez-Gutierrez, Belen, Hock Tan, Ban, Carratala, Jordi, Oriol, Isabel, Paul, Mical, Cohen-Sinai, Noa, Lopez-Medrano, Francisco, San-Juan, Rafael, Montejo, Miguel, Freire, Maristela P., Cordero, Elisa, David, Miruna D., Merino, Esperanza, Mehta Steinke, Seema, Grossi, Paolo A., Cano, Angela, Seminari, Elena M., Valerio, Maricela, Gunseren, Filiz, Rana, Meenakshi, Mularoni, Alessandra, Martin-Davila, Pilar, van Delden, Christian, Hamiyet Demirkaya, Melike, Kocak Tufan, Zeliha, Loeches, Belen, Iyer, Ranganathan N., Soldani, Fabio, Eriksson, Britt-Marie, Pilmis, Benoit, Rizzi, Marco, Coussement, Julien, Clemente, Wanessa T., Roilides, Emmanuel, Pascual, Alvaro, Martinez-Martinez, Luis, Rodriguez-Bano, Jesus, Torre-Cisneros, Julian, and Maria Aguado, Jose

Abstract

Background Whether active therapy with beta-lactam/beta-lactamase inhibitors (BLBLI) is as affective as carbapenems for extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-E) bloodstream infection (BSI) secondary to urinary tract infection (UTI) in kidney transplant recipients (KTRs) remains unclear. Methods We retrospectively evaluated 306 KTR admitted to 30 centers from January 2014 to October 2016. Therapeutic failure (lack of cure or clinical improvement and/or death from any cause) at days 7 and 30 from ESBL-E BSI onset was the primary and secondary study outcomes, respectively. Results Therapeutic failure at days 7 and 30 occurred in 8.2% (25/306) and 13.4% (41/306) of patients. Hospital-acquired BSI (adjusted OR [aOR]: 4.10; 95% confidence interval [CI]: 1.50-11.20) and Pitt score (aOR: 1.47; 95% CI: 1.21-1.77) were independently associated with therapeutic failure at day 7. Age-adjusted Charlson Index (aOR: 1.25; 95% CI: 1.05-1.48), Pitt score (aOR: 1.72; 95% CI: 1.35-2.17), and lymphocyte count <= 500 cells/mu L at presentation (aOR: 3.16; 95% CI: 1.42-7.06) predicted therapeutic failure at day 30. Carbapenem monotherapy (68.6%, primarily meropenem) was the most frequent active therapy, followed by BLBLI monotherapy (10.8%, mostly piperacillin-tazobactam). Propensity score (PS)-adjusted models revealed no significant impact of the choice of active therapy (carbapenem-containing vs any other regimen, BLBLI- vs carbapenem-based monotherapy) within the first 72 hours on any of the study outcomes. Conclusions Our data suggest that active therapy based on BLBLI may be as effective as carbapenem-containing regimens for ESBL-E BSI secondary to UTI in the specific population of KTR. Potential residual confounding and unpowered sample size cannot be excluded (ClinicalTrials.gov identifier: NCT02852902).

Published
2021
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19. Use of carbapenems in the combined treatment of emerging ceftazidime/avibactam-resistant and carbapenem-susceptible KPC-producing Klebsiella pneumoniae infections: Report of a case and review of the literature

Author

Cano, Ángela, Guzmán-Puche, Julia, García-Gutiérrez, Manuel, Castón, Juan José, Gracia-Ahufinger, Irene, Pérez-Nadales, Elena, Recio, Manuel, Natera, Alejandra M., Marfil-Pérez, Eduardo, Martínez-Martínez, Luis, and Torre-Cisneros, Julian

Published
2020
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20. Genomic analysis of 40 prophages located in the genomes of 16 carbapenemase-producing clinical strains of Klebsiella pneumoniae

Author

Bleriot, Ines, primary, Trastoy, Rocío, additional, Blasco, Lucia, additional, Fernández-Cuenca, Felipe, additional, Ambroa, Antón, additional, Fernández-García, Laura, additional, Pacios, Olga, additional, Perez-Nadales, Elena, additional, Torre-Cisneros, Julian, additional, Oteo-Iglesias, Jesús, additional, Navarro, Ferran, additional, Miró, Elisenda, additional, Pascual, Alvaro, additional, Bou, German, additional, Martínez-Martínez, Luis, additional, and Tomas, Maria, additional

Published
2020
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22. The transmembrane protein Sho1 cooperates with the mucin Msb2 to regulate invasive growth and plant infection in Fusarium oxysporum

Author

Perez‐Nadales, Elena and Di Pietro, Antonio

Subjects
Fungal Proteins, Fusarium, Virulence, Gene Expression Regulation, Fungal, Molecular Sequence Data, food and beverages, Plant Development, Original Articles, Plants, Protein Binding
Abstract

In the vascular wilt pathogen Fusarium oxysporum, the mitogen-activated protein kinase (MAPK) Fmk1 is essential for plant infection. The mucin-like membrane protein Msb2 regulates a subset of Fmk1-dependent functions. Here, we examined the role of the tetraspan transmembrane protein Sho1 as an additional regulator of the Fmk1 pathway and determined its genetic interaction with Msb2. Targeted Δsho1 mutants were generated in wild-type and Δmsb2 backgrounds to test possible interactions between the two genes. The mutants were examined for hyphal growth under different stress conditions, phosphorylation of the MAPK Fmk1 and an array of Fmk1-dependent virulence functions. Similar to Msb2, Sho1 was required for the activation of Fmk1 phosphorylation, as well as Fmk1-dependent gene expression and invasive growth functions, including extracellular pectinolytic activity, cellophane penetration, plant tissue colonization and virulence on tomato plants. Δsho1 mutants were hypersensitive to the cell wall-perturbing compound Calcofluor White, and this phenotype was exacerbated in the Δmsb2 Δsho1 double mutant. These results highlight that Sho1 and Msb2 have partially overlapping functions upstream of the Fmk1 MAPK cascade, to promote invasive growth and plant infection, as well as cell wall integrity, in F. oxysporum.

Published
2014

23. Fungal model systems and the elucidation of pathogenicity determinants

Author

Perez-Nadales, Elena, Almeida Nogueira, Maria Filomena, Baldin, Clara, Castanheira, Sónia, El Ghalid, Mennat, Grund, Elisabeth, Lengeler, Klaus, Marchegiani, Elisabetta, Mehrotra, Pankaj Vinod, Moretti, Marino, Naik, Vikram, Oses-Ruiz, Miriam, Oskarsson, Therese, Schäfer, Katja, Wasserstrom, Lisa, Brakhage, Axel A., Gow, Neil A.R., Kahmann, Regine, Lebrun, Marc-Henri, Perez-Martin, José, Di Pietro, Antonio, Talbot, Nicholas J., Toquin, Valerie, Walther, Andrea, Wendland, Jürgen, Universidad de Córdoba [Cordoba], University of Aberdeen, Leibniz Institute for Natural Product Research and Infection Biology (Hans Knoell Institute), Friedrich-Schiller-Universität = Friedrich Schiller University Jena [Jena, Germany], Universidad de Salamanca, Génomique fonctionnelle des champignons pathogènes des plantes (FungiPath), Microbiologie, adaptation et pathogénie (MAP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Carlsberg Group, Carlsberg Laboratory, BIOlogie et GEstion des Risques en agriculture (BIOGER), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Department of Organismic Interactions [Marburg], Max Planck Institute for Terrestrial Microbiology, Max-Planck-Gesellschaft-Max-Planck-Gesellschaft, School of Biosciences, University of Exeter, Bayer SAS, Carlsberg Laboratory-Carlsberg Laboratory, Green Infrastructure approach: linking environmental with social aspects in studying and managing urban forests, COST, European Cooperation in Science and Technology, Institut fur Genetik und Mikrobiologie, Max-Planck-Institut, Istituto Nazionale di Fisica Nucleare, Sezione di Catania (INFN), Università degli studi di Catania [Catania], Biochemistry Dept, Bayer Cropscience, Cooperative Institute for Meteorological Satellite Studies (CIMSS), and University of Wisconsin-Madison-NASA-National Oceanic and Atmospheric Administration (NOAA)

Subjects
Mitogen-Activated Protein Kinase Kinases, Virulence, Fungal model organism, [SDV]Life Sciences [q-bio], Fungi, Secondary Metabolism, food and beverages, Review, Genomics, Microbiology, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Genetics, Human fungal pathogen, Plant fungal pathogen, Chromosomes, Fungal, Genome, Fungal, ComputingMilieux_MISCELLANEOUS, [SDV.EE.IEO]Life Sciences [q-bio]/Ecology, environment/Symbiosis
Abstract

Highlights • History of seven fungal species used as models for studying development and pathogenicity. • Outline of central stages of their life cycle and their infection processes. • Molecular toolkits used to study different aspects of pathogenicity. • Insight gained from genome sequencing projects. • Current research trends and future challenges., Fungi have the capacity to cause devastating diseases of both plants and animals, causing significant harvest losses that threaten food security and human mycoses with high mortality rates. As a consequence, there is a critical need to promote development of new antifungal drugs, which requires a comprehensive molecular knowledge of fungal pathogenesis. In this review, we critically evaluate current knowledge of seven fungal organisms used as major research models for fungal pathogenesis. These include pathogens of both animals and plants; Ashbya gossypii, Aspergillus fumigatus, Candida albicans, Fusarium oxysporum, Magnaporthe oryzae, Ustilago maydis and Zymoseptoria tritici. We present key insights into the virulence mechanisms deployed by each species and a comparative overview of key insights obtained from genomic analysis. We then consider current trends and future challenges associated with the study of fungal pathogenicity.

Published
2014

24. Clinical characteristics, treatment and outcomes of MRSA bacteraemia in the elderly

Author

Cuervo, Guillermo, primary, Gasch, Oriol, additional, Shaw, Evelyn, additional, Camoez, Mariana, additional, Domínguez, María Ángeles, additional, Padilla, Belén, additional, Pintado, Vicente, additional, Almirante, Benito, additional, Lepe, José A., additional, López-Medrano, Francisco, additional, Ruiz de Gopegui, Enrique, additional, Martínez, José A., additional, Montejo, José Miguel, additional, Perez-Nadales, Elena, additional, Arnáiz, Ana, additional, Goenaga, Miguel Ángel, additional, Benito, Natividad, additional, Horcajada, Juan Pablo, additional, Rodríguez-Baño, Jesús, additional, Pujol, Miquel, additional, Jover, A., additional, Barcenilla, F., additional, Garcia, M., additional, Pujol, M., additional, Gasch, O., additional, Domínguez, M.A., additional, Camoez, M., additional, Dueñas, C., additional, Ojeda, E., additional, Martinez, J.A., additional, Marco, F., additional, Chaves, F., additional, Lagarde, M., additional, López-Medrano, F., additional, Montejo, J.M., additional, Bereciartua, E., additional, Hernández, J.L., additional, Von Wichmann, M.A., additional, Goenaga, M.A., additional, García-Arenzana, J.M., additional, Padilla, B., additional, Padilla, C., additional, Cercenado, E., additional, García-Pardo, G., additional, Tapiol, J., additional, Horcajada, J.P., additional, Montero, M., additional, Salvado, M., additional, Arnáiz, A., additional, Fernandez, C., additional, Calbo, E., additional, Xercavins, M., additional, Granados, A., additional, Fontanals, D., additional, Pintado, V., additional, Loza, E., additional, Torre-Cisneros, J., additional, Lara, R., additional, Rodríguez-López, F., additional, Rodríguez, M., additional, Natera, C., additional, Gracia-Ahufinger, I., additional, Blanco, J.R., additional, Olarte, I., additional, Benito, N., additional, Mirelis, B., additional, Murillas, J., additional, Ruiz de Gopegui, E., additional, Espejo, E., additional, Morera, M.A., additional, Rodríguez-Baño, J., additional, López-Cortés, L.E., additional, Pascual, A., additional, Martín, C., additional, Lepe, J.A., additional, Molina, J., additional, Sordé, R., additional, Almirante, B., additional, and Larrosa, N., additional

Published
2016
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25. Fungal model systems and the elucidation of pathogenicity determinants

Author

Wellcome Trust, European Commission, Perez-Nadales, Elena, Castanheira, Sónia, Pérez-Martín, José, Wellcome Trust, European Commission, Perez-Nadales, Elena, Castanheira, Sónia, and Pérez-Martín, José

Abstract

Fungi have the capacity to cause devastating diseases of both plants and animals, causing significant harvest losses that threaten food security and human mycoses with high mortality rates. As a consequence, there is a critical need to promote development of new antifungal drugs, which requires a comprehensive molecular knowledge of fungal pathogenesis. In this review, we critically evaluate current knowledge of seven fungal organisms used as major research models for fungal pathogenesis. These include pathogens of both animals and plants; Ashbya gossypii, Aspergillus fumigatus, Candida albicans, Fusarium oxysporum, Magnaporthe oryzae, Ustilago maydis and Zymoseptoria tritici. We present key insights into the virulence mechanisms deployed by each species and a comparative overview of key insights obtained from genomic analysis. We then consider current trends and future challenges associated with the study of fungal pathogenicity. © 2014 The Authors.

Published
2014

27. Comparative genomics of MAP kinase and calcium–calcineurin signalling components in plant and human pathogenic fungi

Author

Rispail, Nicolas, primary, Soanes, Darren M., additional, Ant, Cemile, additional, Czajkowski, Robert, additional, Grünler, Anke, additional, Huguet, Romain, additional, Perez-Nadales, Elena, additional, Poli, Anna, additional, Sartorel, Elodie, additional, Valiante, Vito, additional, Yang, Meng, additional, Beffa, Roland, additional, Brakhage, Axel A., additional, Gow, Neil A.R., additional, Kahmann, Regine, additional, Lebrun, Marc-Henri, additional, Lenasi, Helena, additional, Perez-Martin, José, additional, Talbot, Nicholas J., additional, Wendland, Jürgen, additional, and Di Pietro, Antonio, additional

Published
2009
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28. The transmembrane protein Sho1 cooperates with the mucin Msb2 to regulate invasive growth and plant infection in Fusarium oxysporum.

Author

Perez‐Nadales, Elena and Di Pietro, Antonio

Subjects
*FUSARIUM oxysporum, *MEMBRANE proteins, *PLANT growth regulation, *MITOGEN-activated protein kinases, *GENE expression in plants
Abstract

In the vascular wilt pathogen Fusarium oxysporum, the mitogen-activated protein kinase ( MAPK) Fmk1 is essential for plant infection. The mucin-like membrane protein Msb2 regulates a subset of Fmk1-dependent functions. Here, we examined the role of the tetraspan transmembrane protein Sho1 as an additional regulator of the Fmk1 pathway and determined its genetic interaction with Msb2. Targeted Δ sho1 mutants were generated in wild-type and Δ msb2 backgrounds to test possible interactions between the two genes. The mutants were examined for hyphal growth under different stress conditions, phosphorylation of the MAPK Fmk1 and an array of Fmk1-dependent virulence functions. Similar to Msb2, Sho1 was required for the activation of Fmk1 phosphorylation, as well as Fmk1-dependent gene expression and invasive growth functions, including extracellular pectinolytic activity, cellophane penetration, plant tissue colonization and virulence on tomato plants. Δ sho1 mutants were hypersensitive to the cell wall-perturbing compound Calcofluor White, and this phenotype was exacerbated in the Δ msb2 Δ sho1 double mutant. These results highlight that Sho1 and Msb2 have partially overlapping functions upstream of the Fmk1 MAPK cascade, to promote invasive growth and plant infection, as well as cell wall integrity, in F. oxysporum. [ABSTRACT FROM AUTHOR]

Published
2015
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32. Mortality Associated with Bacteremia Due to Colistin-Resistant Klebsiella pneumoniae with High-Level Meropenem Resistance: Importance of Combination Therapy without Colistin and Carbapenems

Author

Irene Gracia-Ahufinger, Elena Pérez-Nadales, Julia Guzmán-Puche, Jesús Rodríguez-Baño, Belén Gutiérrez-Gutiérrez, Clara Natera, Marina Rodríguez, Fernando Rodríguez-López, Rafael León, Isabel Machuca, Juan José Castón, Julián Torre-Cisneros, Francisco Rivera Espinar, Angela Cano, Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), Red Española de Investigación en Patología Infecciosa, European Commission, [Machuca, Isabel] Univ Cordoba, Hosp Univ Reina Sofia IMIBIC, Infect Dis Unit, Cordoba, Spain, [Cano, Angela] Univ Cordoba, Hosp Univ Reina Sofia IMIBIC, Infect Dis Unit, Cordoba, Spain, [Perez-Nadales, Elena] Univ Cordoba, Hosp Univ Reina Sofia IMIBIC, Infect Dis Unit, Cordoba, Spain, [Natera, Clara] Univ Cordoba, Hosp Univ Reina Sofia IMIBIC, Infect Dis Unit, Cordoba, Spain, [Caston, Juan J.] Univ Cordoba, Hosp Univ Reina Sofia IMIBIC, Infect Dis Unit, Cordoba, Spain, [Torre-Cisneros, Julian] Univ Cordoba, Hosp Univ Reina Sofia IMIBIC, Infect Dis Unit, Cordoba, Spain, [Gutierrez-Gutierrez, Belen] Univ Seville, Hosp Univ Virgen Macarena IBiS, Infect Dis & Clin Microbiol Unit, Seville, Spain, [Rodriguez-Bano, Jesus] Univ Seville, Hosp Univ Virgen Macarena IBiS, Infect Dis & Clin Microbiol Unit, Seville, Spain, [Gutierrez-Gutierrez, Belen] Univ Seville, Dept Med, Seville, Spain, [Rodriguez-Bano, Jesus] Univ Seville, Dept Med, Seville, Spain, [Gracia-Ahufinger, Irene] Univ Cordoba, Hosp Univ Reina Sofia IMIBIC, Microbiol Unit, Cordoba, Spain, [Guzman-Puche, Julia] Univ Cordoba, Hosp Univ Reina Sofia IMIBIC, Microbiol Unit, Cordoba, Spain, [Rodriguez-Lopez, Fernando] Univ Cordoba, Hosp Univ Reina Sofia IMIBIC, Microbiol Unit, Cordoba, Spain, [Rivera Espinar, Francisco] Univ Cordoba, Hosp Univ Reina Sofia IMIBIC, Intens Care Unit, Cordoba, Spain, [Rodriguez, Marina] Univ Cordoba, Hosp Univ Reina Sofia IMIBIC, Intens Care Unit, Cordoba, Spain, [Leon, Rafael] Univ Cordoba, Hosp Univ Reina Sofia IMIBIC, Intens Care Unit, Cordoba, Spain, European Development Regional Fund, and Planes Nacionales de, Instituto de Salud Carlos III, Subdireccion General de Redes y Centros de Investigacion Cooperativa, Ministerio de Economia y Competitividad, Spanish Network for Research in Infectious Diseases

Subjects
Male, 0301 basic medicine, Imipenem, Carbapenem, Minocycline, Bacteremia, Definitions, Tigecycline, Drug Resistance, Multiple, Bacterial, polycyclic compounds, Pharmacology (medical), Prospective Studies, Blood-stream infections, Gentamicin, Hazard ratio, Middle Aged, Shock, Septic, Anti-Bacterial Agents, Drug Combinations, Klebsiella pneumoniae, Impact, Infectious Diseases, K.-pneumoniae, carbapenems, Female, medicine.drug, medicine.medical_specialty, Combination therapy, 030106 microbiology, Outcomes, Emergence, Microbial Sensitivity Tests, Clinical Therapeutics, Meropenem, 03 medical and health sciences, Enterobacteriaceae, Fosfomycin, Sepsis, Internal medicine, medicine, Humans, Mortality, Aged, Pharmacology, Predictors, Colistin, Septic shock, business.industry, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, medicine.disease, mortality, Klebsiella Infections, Carbapenems, Thienamycins, Gentamicins, business
Abstract

Combination therapy including colistin and a carbapenem has been found to be associated with lower mortality in the treatment of bloodstream infections (BSI) due to KPC-producing Klebsiella pneumoniae when the isolates show a meropenem or imipenem MIC of, This study was funded by Planes Nacionales de I+D+i 2008-2011 and 2013-2016, Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Economía y Competitividad, Spanish Network for Research in Infectious Diseases (REIPI RD12/0015/0010 and REIPI RD16/0016/0001; RD16/0016/0001; RD16/00167008) and cofinanced by European Development Regional Fund “A way to achieve Europe” and operative program Intelligent Growth 2014-2020.

Published
2017

33. Fungal model systems and the elucidation of pathogenicity determinants.

Author

Perez-Nadales E, Nogueira MF, Baldin C, Castanheira S, El Ghalid M, Grund E, Lengeler K, Marchegiani E, Mehrotra PV, Moretti M, Naik V, Oses-Ruiz M, Oskarsson T, Schäfer K, Wasserstrom L, Brakhage AA, Gow NA, Kahmann R, Lebrun MH, Perez-Martin J, Di Pietro A, Talbot NJ, Toquin V, Walther A, and Wendland J

Subjects
Fungi metabolism, Mitogen-Activated Protein Kinase Kinases metabolism, Secondary Metabolism, Virulence, Chromosomes, Fungal, Fungi genetics, Fungi pathogenicity, Genome, Fungal
Abstract

Fungi have the capacity to cause devastating diseases of both plants and animals, causing significant harvest losses that threaten food security and human mycoses with high mortality rates. As a consequence, there is a critical need to promote development of new antifungal drugs, which requires a comprehensive molecular knowledge of fungal pathogenesis. In this review, we critically evaluate current knowledge of seven fungal organisms used as major research models for fungal pathogenesis. These include pathogens of both animals and plants; Ashbya gossypii, Aspergillus fumigatus, Candida albicans, Fusarium oxysporum, Magnaporthe oryzae, Ustilago maydis and Zymoseptoria tritici. We present key insights into the virulence mechanisms deployed by each species and a comparative overview of key insights obtained from genomic analysis. We then consider current trends and future challenges associated with the study of fungal pathogenicity., (Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.)

Published
2014
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34. Dissecting the contribution of p16(INK4A) and the Rb family to the Ras transformed phenotype.

Author

Mitchell PJ, Perez-Nadales E, Malcolm DS, and Lloyd AC

Subjects
Animals, Antigens, Viral, Tumor biosynthesis, Antigens, Viral, Tumor genetics, Cell Adhesion physiology, Cell Division genetics, Cell Transformation, Neoplastic metabolism, Cells, Cultured, Contact Inhibition genetics, Cyclin-Dependent Kinase Inhibitor p16 deficiency, Cyclin-Dependent Kinase Inhibitor p16 genetics, Genetic Vectors, Green Fluorescent Proteins, Luminescent Proteins genetics, Rats, Retinoblastoma Protein antagonists & inhibitors, Schwann Cells cytology, Schwann Cells metabolism, Transfection, Tumor Suppressor Protein p53 deficiency, Tumor Suppressor Protein p53 genetics, ras Proteins genetics, Cell Transformation, Neoplastic genetics, Cyclin-Dependent Kinase Inhibitor p16 metabolism, Retinoblastoma Protein genetics, ras Proteins metabolism
Abstract

Although oncogenic Ras commonly contributes to the development of cancer, in normal primary cells it induces cell cycle arrest rather than transformation. Here we analyze the additional genetic changes required for Ras to promote cell cycle progression rather than arrest. We show that loss of p53 is sufficient for oncogenic Ras to stimulate proliferation in the absence of extrinsic mitogens in attached cells. However, surprisingly, we find that p53 loss is not sufficient for Ras to overcome anchorage dependence or contact inhibition. In contrast, expression of simian virus 40 (SV40) large T antigen (LT) allows Ras to overcome these additional cell cycle controls. Mutational analysis of SV40 LT shows that this action of SV40 LT depends on its ability to inactivate the retinoblastoma (Rb) family of proteins, in concert with the loss of p53. Importantly, we show that inactivation of the Rb family of proteins can be mimicked by loss of the cyclin-dependent kinase inhibitor p16(INK4A). p16(INK4A) is commonly lost in human tumors, but its contribution to the transformed phenotype is unknown. We demonstrate here a role for p16(INK4A) in the loss of cell cycle controls required for tumorigenesis and show how accumulating genetic changes cooperate and contribute to the transformed phenotype.

Published
2003
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