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8 results on '"Perez-Erviti, Julio A."'

3. Inhibition of Pertussis Toxin by Human α-Defensins-1 and -5: Differential Mechanisms of Action

Author

Kling, Carolin, primary, Sommer, Anja, additional, Almeida-Hernandez, Yasser, additional, Rodríguez, Armando, additional, Perez-Erviti, Julio A., additional, Bhadane, Rajendra, additional, Ständker, Ludger, additional, Wiese, Sebastian, additional, Barth, Holger, additional, Pupo-Meriño, Mario, additional, Pulliainen, Arto T., additional, Sánchez-García, Elsa, additional, and Ernst, Katharina, additional

Published
2023
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4. Cm-p5 Peptide Dimers Inhibit Biofilms of Candida albicans Clinical Isolates, C. parapsilosis and Fluconazole-Resistant Mutants of C. auris

Author

Amann, Valerie, primary, Kissmann, Ann-Kathrin, additional, Mildenberger, Vanessa, additional, Krebs, Imke, additional, Perez-Erviti, Julio A., additional, Martell-Huguet, Ernesto M., additional, Otero-Gonzalez, Anselmo J., additional, Morales-Vicente, Fidel, additional, Rodríguez-Castaño, Gina P., additional, Firacative, Carolina, additional, Rodríguez, Armando, additional, Ständker, Ludger, additional, Weil, Tanja, additional, Spellerberg, Barbara, additional, Stenger, Steffen, additional, and Rosenau, Frank, additional

Published
2023
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5. Combination of Six Individual Derivatives of the Pom-1 Antibiofilm Peptide Doubles Their Efficacy against Invasive and Multi-Resistant Clinical Isolates of the Pathogenic Yeast Candida albicans

Author

Häring, Michelle, primary, Amann, Valerie, additional, Kissmann, Ann-Kathrin, additional, Herberger, Tilmann, additional, Synatschke, Christopher, additional, Kirsch-Pietz, Nicole, additional, Perez-Erviti, Julio A., additional, Otero-Gonzalez, Anselmo J., additional, Morales-Vicente, Fidel, additional, Andersson, Jakob, additional, Weil, Tanja, additional, Stenger, Steffen, additional, Rodríguez, Armando, additional, Ständker, Ludger, additional, and Rosenau, Frank, additional

Published
2022
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6. Combination of six individual derivatives of the pom-1 antibiofilm peptide doubles their efficacy against invasive and multi-resistant clinical isolates of the pathogenic yeast candida albicans

Author

Häring, Michelle, Amann, Valerie, Kissmann, Ann-Kathrin, Herberger, Tilmann, Synatschke, Christopher, Kirsch-Pietz, Nicole, Perez-Erviti, Julio A., Otero-Gonzalez, Anselmo J., Morales-Vicente, Fidel, Andersson, Jakob, Weil, Tanja, Stenger, Steffen, Rodríguez, Armando, Ständker, Ludger, Rosenau, Frank, Cacciatore, Ivana, European Union (EU), and Horizon 2020

Subjects
Peptide antibiotics, antimicrobial peptides, DDC 570 / Life sciences, invasive clinical isolates, ddc:570, ddc:610, DDC 610 / Medicine & health, Kombinationstherapie, combination therapy
Abstract

In previous studies, derivatives of the peptide Pom-1, which was originally extracted from the freshwater mollusk Pomacea poeyana, showed an exceptional ability to specifically inhibit biofilm formation of the laboratory strain ATCC 90028 as a model strain of the pathogenic yeast Candida albicans. In follow-up, here, we demonstrate that the derivatives Pom-1A to Pom-1F are also active against biofilms of invasive clinical C. albicans isolates, including strains resistant against fluconazole and/or amphotericin B. However, efficacy varied strongly between the isolates, as indicated by large deviations in the experiments. This lack of robustness could be efficiently bypassed by using mixtures of all peptides. These mixed peptide preparations were active against biofilm formation of all the isolates with uniform efficacies, and the total peptide concentration could be halved compared to the original MIC of the individual peptides (2.5 µg/mL). Moreover, mixing the individual peptides restored the antifungal effect of fluconazole against fluconazole-resistant isolates even at 50% of the standard therapeutic concentration. Without having elucidated the reason for these synergistic effects of the peptides yet, both the gain of efficacy and the considerable increase in efficiency by combining the peptides indicate that Pom-1 and its derivatives in suitable formulations may play an important role as new antibiofilm antimycotics in the fight against invasive clinical infections with (multi-) resistant C. albicans., publishedVersion

Published
2022
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7. Increased Activities against Biofilms of the Pathogenic Yeast Candida albicans of Optimized Pom-1 Derivatives

Author

Amann, Valerie, primary, Kissmann, Ann-Kathrin, additional, Krämer, Markus, additional, Krebs, Imke, additional, Perez-Erviti, Julio A., additional, Otero-Gonzalez, Anselmo J., additional, Morales-Vicente, Fidel, additional, Rodríguez, Armando, additional, Ständker, Ludger, additional, Weil, Tanja, additional, and Rosenau, Frank, additional

Published
2022
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