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749 results on '"Perez-Atayde, Antonio R."'

6. Accuracy of Cardiac Magnetic Resonance Imaging in Diagnosing Pediatric Cardiac Masses: A Multicenter Study

Author

Beroukhim, Rebecca S., Ghelani, Sunil, Ashwath, Ravi, Balasubramanian, Sowmya, Biko, David M., Buddhe, Sujatha, Campbell, M. Jay, Cross, Russell, Festa, Pierluigi, Griffin, Lindsay, Grotenhuis, Heynric, Hasbani, Keren, Hashemi, Sassan, Hegde, Sanjeet, Hussain, Tarique, Jain, Supriya, Kiaffas, Maria, Kutty, Shelby, Lam, Christopher Z., Liberato, Gabriela, Merlocco, Anthony, Misra, Nilanjana, Mowers, Katie L., Muniz, Juan Carlos, Nutting, Arni, Parra, David A., Patel, Jyoti K., Perez-Atayde, Antonio R., Prasad, Deepa, Rosental, Carlos F., Shah, Amee, Samyn, Margaret M., Sleeper, Lynn A., Slesnick, Timothy, Valsangiacomo, Emanuela, and Geva, Tal

Published
2022
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15. Recurrent EML4–NTRK3 fusions in infantile fibrosarcoma and congenital mesoblastic nephroma suggest a revised testing strategy

Author

Church, Alanna J, Calicchio, Monica L, Nardi, Valentina, Skalova, Alena, Pinto, Andre, Dillon, Deborah A, Gomez-Fernandez, Carmen R, Manoj, Namitha, Haimes, Josh D, Stahl, Joshua A, Dela Cruz, Filemon S, Tannenbaum-Dvir, Sarah, Glade-Bender, Julia L, Kung, Andrew L, DuBois, Steven G, Kozakewich, Harry P, Janeway, Katherine A, Perez-Atayde, Antonio R, and Harris, Marian H

Published
2018
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16. A somatic activating NRAS variant associated with kaposiform lymphangiomatosis

Author

Barclay, Sarah F., Inman, Kyle W., Luks, Valerie L., McIntyre, John B., Al-Ibraheemi, Alyaa, Church, Alanna J., Perez-Atayde, Antonio R., Mangray, Shamlal, Jeng, Michael, Kreimer, Sara R., Walker, Lori, Fishman, Steven J., Alomari, Ahmad I., Chaudry, Gulraiz, Trenor III, Cameron C., Adams, Denise, Kozakewich, Harry P. W., and Kurek, Kyle C.

Published
2019
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17. Foregut Duplication Cysts

Author

Kieran, Stephen, Perez-Atayde, Antonio R., Rahbar, Reza, Rahbar, Reza, editor, Rodriguez-Galindo, Carlos, editor, Meara, John G., editor, Smith, Edward R., editor, and Perez-Atayde, Antonio R., editor

Published
2014
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21. Data from EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma

Author

Durbin, Adam D., primary, Wang, Tingjian, primary, Wimalasena, Virangika K., primary, Zimmerman, Mark W., primary, Li, Deyao, primary, Dharia, Neekesh V., primary, Mariani, Luca, primary, Shendy, Noha A.M., primary, Nance, Stephanie, primary, Patel, Anand G., primary, Shao, Ying, primary, Mundada, Maya, primary, Maxham, Lily, primary, Park, Paul M.C., primary, Sigua, Logan H., primary, Morita, Ken, primary, Conway, Amy Saur, primary, Robichaud, Amanda L., primary, Perez-Atayde, Antonio R., primary, Bikowitz, Melissa J., primary, Quinn, Taylor R., primary, Wiest, Olaf, primary, Easton, John, primary, Schönbrunn, Ernst, primary, Bulyk, Martha L., primary, Abraham, Brian J., primary, Stegmaier, Kimberly, primary, Look, A. Thomas, primary, and Qi, Jun, primary

Published
2023
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22. Supplementary Data from EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma

Author

Durbin, Adam D., primary, Wang, Tingjian, primary, Wimalasena, Virangika K., primary, Zimmerman, Mark W., primary, Li, Deyao, primary, Dharia, Neekesh V., primary, Mariani, Luca, primary, Shendy, Noha A.M., primary, Nance, Stephanie, primary, Patel, Anand G., primary, Shao, Ying, primary, Mundada, Maya, primary, Maxham, Lily, primary, Park, Paul M.C., primary, Sigua, Logan H., primary, Morita, Ken, primary, Conway, Amy Saur, primary, Robichaud, Amanda L., primary, Perez-Atayde, Antonio R., primary, Bikowitz, Melissa J., primary, Quinn, Taylor R., primary, Wiest, Olaf, primary, Easton, John, primary, Schönbrunn, Ernst, primary, Bulyk, Martha L., primary, Abraham, Brian J., primary, Stegmaier, Kimberly, primary, Look, A. Thomas, primary, and Qi, Jun, primary

Published
2023
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26. Data from Differentiation of NUT Midline Carcinoma by Epigenomic Reprogramming

Author

Schwartz, Brian E., primary, Hofer, Matthias D., primary, Lemieux, Madeleine E., primary, Bauer, Daniel E., primary, Cameron, Michael J., primary, West, Nathan H., primary, Agoston, Elin S., primary, Reynoird, Nicolas, primary, Khochbin, Saadi, primary, Ince, Tan A., primary, Christie, Amanda, primary, Janeway, Katherine A., primary, Vargas, Sara O., primary, Perez-Atayde, Antonio R., primary, Aster, Jon C., primary, Sallan, Stephen E., primary, Kung, Andrew L., primary, Bradner, James E., primary, and French, Christopher A., primary

Published
2023
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27. Supplementary Figures 1-2 from Differentiation of NUT Midline Carcinoma by Epigenomic Reprogramming

Author

Schwartz, Brian E., primary, Hofer, Matthias D., primary, Lemieux, Madeleine E., primary, Bauer, Daniel E., primary, Cameron, Michael J., primary, West, Nathan H., primary, Agoston, Elin S., primary, Reynoird, Nicolas, primary, Khochbin, Saadi, primary, Ince, Tan A., primary, Christie, Amanda, primary, Janeway, Katherine A., primary, Vargas, Sara O., primary, Perez-Atayde, Antonio R., primary, Aster, Jon C., primary, Sallan, Stephen E., primary, Kung, Andrew L., primary, Bradner, James E., primary, and French, Christopher A., primary

Published
2023
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32. LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors

Author

Massachusetts Institute of Technology. Department of Biology, Whitehead Institute for Biomedical Research, Tao, Ting, Shi, Hui, Mariani, Luca, Abraham, Brian J., Durbin, Adam D., Zimmerman, Mark W., Powers, John T., Missios, Pavlos, Ross, Kenneth N., Perez-Atayde, Antonio R., Bulyk, Martha L., Young, Richard A., Daley, George Q., Look, A. Thomas, Massachusetts Institute of Technology. Department of Biology, Whitehead Institute for Biomedical Research, Tao, Ting, Shi, Hui, Mariani, Luca, Abraham, Brian J., Durbin, Adam D., Zimmerman, Mark W., Powers, John T., Missios, Pavlos, Ross, Kenneth N., Perez-Atayde, Antonio R., Bulyk, Martha L., Young, Richard A., Daley, George Q., and Look, A. Thomas

Abstract

© 2020 National Academy of Sciences. All rights reserved. LIN28B is highly expressed in neuroblastoma and promotes tumorigenesis, at least, in part, through inhibition of let-7 microRNA biogenesis. Here, we report that overexpression of either wild-type (WT) LIN28B or a LIN28B mutant that is unable to inhibit let-7 processing increases the penetrance of MYCN-induced neuroblastoma, potentiates the invasion and migration of transformed sympathetic neuroblasts, and drives distant metastases in vivo. Genome-wide chromatin immunoprecipitation coupled with massively parallel DNA sequencing (ChIP-seq) and coimmunoprecipitation experiments show that LIN28B binds active gene promoters in neuroblastoma cells through protein–protein interaction with the sequence-specific zinc-finger transcription factor ZNF143 and activates the expression of downstream targets, including transcription factors forming the adrenergic core regulatory circuitry that controls the malignant cell state in neuroblastoma as well as GSK3B and L1CAM that are involved in neuronal cell adhesion and migration. These findings reveal an unexpected let-7–independent function of LIN28B in transcriptional regulation during neuroblastoma pathogenesis.

Published
2022

33. Accuracy of Cardiac Magnetic Resonance Imaging in Diagnosing Pediatric Cardiac Masses: A Multicenter Study

Author

Cardiologie patientenzorg, Child Health, Circulatory Health, Beroukhim, Rebecca S, Ghelani, Sunil, Ashwath, Ravi, Balasubramanian, Sowmya, Biko, David M, Buddhe, Sujatha, Campbell, M Jay, Cross, Russell, Festa, Pierluigi, Griffin, Lindsay, Grotenhuis, Heynric, Hasbani, Keren, Hashemi, Sassan, Hegde, Sanjeet, Hussain, Tarique, Jain, Supriya, Kiaffas, Maria, Kutty, Shelby, Lam, Christopher Z, Liberato, Gabriela, Merlocco, Anthony, Misra, Nilanjana, Mowers, Katie L, Muniz, Juan Carlos, Nutting, Arni, Parra, David A, Patel, Jyoti K, Perez-Atayde, Antonio R, Prasad, Deepa, Rosental, Carlos F, Shah, Amee, Samyn, Margaret M, Sleeper, Lynn A, Slesnick, Timothy, Valsangiacomo, Emanuela, Geva, Tal, Cardiologie patientenzorg, Child Health, Circulatory Health, Beroukhim, Rebecca S, Ghelani, Sunil, Ashwath, Ravi, Balasubramanian, Sowmya, Biko, David M, Buddhe, Sujatha, Campbell, M Jay, Cross, Russell, Festa, Pierluigi, Griffin, Lindsay, Grotenhuis, Heynric, Hasbani, Keren, Hashemi, Sassan, Hegde, Sanjeet, Hussain, Tarique, Jain, Supriya, Kiaffas, Maria, Kutty, Shelby, Lam, Christopher Z, Liberato, Gabriela, Merlocco, Anthony, Misra, Nilanjana, Mowers, Katie L, Muniz, Juan Carlos, Nutting, Arni, Parra, David A, Patel, Jyoti K, Perez-Atayde, Antonio R, Prasad, Deepa, Rosental, Carlos F, Shah, Amee, Samyn, Margaret M, Sleeper, Lynn A, Slesnick, Timothy, Valsangiacomo, Emanuela, and Geva, Tal

Published
2022

36. Kaposiform Lymphangiomatosis

Author

Perez-Atayde, Antonio R., primary, Debelenko, Larisa, additional, Al-Ibraheemi, Alyaa, additional, Eng, Whitney, additional, Ruiz-Gutierrez, Melisa, additional, O’Hare, Meghan, additional, Croteau, Stacy E., additional, Trenor, Cameron C., additional, Boyer, Debra, additional, Balkin, Daniel M., additional, Barclay, Sarah F., additional, Hsi Dickie, Belinda, additional, Liang, Marilyn G., additional, Chaudry, Gulraiz, additional, Alomari, Ahmad I., additional, Mulliken, John B., additional, Adams, Denise M., additional, Kurek, Kyle C., additional, Fishman, Steven J., additional, and Kozakewich, Harry P.W., additional

Published
2022
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37. Aberrant AKT activation drives well-differentiated liposarcoma

Author

Gutierrez, Alejandro, Snyder, Eric L., Marino-Enriquez, Adrian, Zhang, Yi-Xiang, Sioletic, Stefano, Kozakewich, Elena, Grebliunaite, Ruta, Ou, Wen-bin, Sicinska, Ewa, Raut, Chandrajit P., Demetri, George D., Perez-Atayde, Antonio R., Wagner, Andrew J., Fletcher, Jonathan A., Fletcher, Christopher D. M., and Look, A. Thomas

Published
2011

39. EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma

Author

Durbin, Adam D., primary, Wang, Tingjian, additional, Wimalasena, Virangika K., additional, Zimmerman, Mark W., additional, Li, Deyao, additional, Dharia, Neekesh V., additional, Mariani, Luca, additional, Shendy, Noha A.M., additional, Nance, Stephanie, additional, Patel, Anand G., additional, Shao, Ying, additional, Mundada, Maya, additional, Maxham, Lily, additional, Park, Paul M.C., additional, Sigua, Logan H., additional, Morita, Ken, additional, Conway, Amy Saur, additional, Robichaud, Amanda L., additional, Perez-Atayde, Antonio R., additional, Bikowitz, Melissa J., additional, Quinn, Taylor R., additional, Wiest, Olaf, additional, Easton, John, additional, Schönbrunn, Ernst, additional, Bulyk, Martha L., additional, Abraham, Brian J., additional, Stegmaier, Kimberly, additional, Look, A. Thomas, additional, and Qi, Jun, additional

Published
2022
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46. LAMP2 Cardiomyopathy: Consequences of Impaired Autophagy in the Heart

Author

Alcalai, Ronny, primary, Arad, Michael, additional, Wakimoto, Hiroko, additional, Yadin, Dor, additional, Gorham, Joshua, additional, Wang, Libin, additional, Burns, Elia, additional, Maron, Barry J., additional, Roberts, William C., additional, Konno, Tetsuo, additional, Conner, David A., additional, Perez‐Atayde, Antonio R., additional, Seidman, Jon G., additional, and Seidman, Christine E., additional

Published
2021
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48. LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors

Author

Tao, Ting, Shi, Hui, Mariani, Luca, Abraham, Brian J, Durbin, Adam D, Zimmerman, Mark W, Powers, John T, Missios, Pavlos, Ross, Kenneth N, Perez-Atayde, Antonio R, Bulyk, Martha L, Young, Richard A, Daley, George Q, Look, A Thomas, Tao, Ting, Shi, Hui, Mariani, Luca, Abraham, Brian J, Durbin, Adam D, Zimmerman, Mark W, Powers, John T, Missios, Pavlos, Ross, Kenneth N, Perez-Atayde, Antonio R, Bulyk, Martha L, Young, Richard A, Daley, George Q, and Look, A Thomas

Abstract

© 2020 National Academy of Sciences. All rights reserved. LIN28B is highly expressed in neuroblastoma and promotes tumorigenesis, at least, in part, through inhibition of let-7 microRNA biogenesis. Here, we report that overexpression of either wild-type (WT) LIN28B or a LIN28B mutant that is unable to inhibit let-7 processing increases the penetrance of MYCN-induced neuroblastoma, potentiates the invasion and migration of transformed sympathetic neuroblasts, and drives distant metastases in vivo. Genome-wide chromatin immunoprecipitation coupled with massively parallel DNA sequencing (ChIP-seq) and coimmunoprecipitation experiments show that LIN28B binds active gene promoters in neuroblastoma cells through protein–protein interaction with the sequence-specific zinc-finger transcription factor ZNF143 and activates the expression of downstream targets, including transcription factors forming the adrenergic core regulatory circuitry that controls the malignant cell state in neuroblastoma as well as GSK3B and L1CAM that are involved in neuronal cell adhesion and migration. These findings reveal an unexpected let-7–independent function of LIN28B in transcriptional regulation during neuroblastoma pathogenesis.

Published
2021

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