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13 results on '"Peres, Diulle Spat"'

3. Targeting TRPV4 Channels for Cancer Pain Relief

Author

Antoniazzi, Caren Tatiane de David, primary, Ruviaro, Náthaly Andrighetto, additional, Peres, Diulle Spat, additional, Rodrigues, Patrícia, additional, Viero, Fernanda Tibolla, additional, and Trevisan, Gabriela, additional

Published
2024
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4. Increased levels of advanced oxidation protein products (AOPPs) were associated with nociceptive behavior and clinical scores in an experimental progressive autoimmune encephalomyelitis model (PMS‐EAE).

Author

Rodrigues, Patrícia, Frare, Julia Maria, Peres, Diulle Spat, Viero, Fernanda Tibolla, Ruviaro, Náthaly Andrighetto, dos Santos Stein, Carolina, da Silva Brum, Evelyne, Moresco, Rafael Noal, Oliveira, Sara Marchesan, Bochi, Guilherme Vargas, and Trevisan, Gabriela

Subjects
NADPH oxidase, ENCEPHALOMYELITIS, CENTRAL nervous system, NEURALGIA, NEST building, FOOT, INDUCED labor (Obstetrics), NEURITIS
Abstract

Multiple sclerosis (MS) is a neurodegenerative disease that affects the central nervous system (CNS) generating neuropathic pain and anxiety. Primary progressive MS (PPMS) is the most disabling clinical form, and the patients present an intense neurodegenerative process. In this context, the advanced oxidation protein products (AOPPs) are oxidized compounds and their accumulation in plasma has been related to clinical disability in MS patients. However, the involvement of AOPPs in neuropathic pain‐ and anxiety‐like symptoms was not previously evaluated. To assess this, female mice C57BL/6J were used to induce progressive experimental autoimmune encephalomyelitis (PMS‐EAE). Clinical score, weight, strength of plantar pressure, rotarod test, mechanical allodynia, and cold hypersensitivity were evaluated before induction (baseline) and on days 7th, 10th, and 14th post‐immunization. We assessed nest building, open field, and elevated plus‐maze tests 13 days post‐immunization. Animals were killed at 14 days post‐immunization; then, AOPPs levels, NADPH oxidase, and myeloperoxidase (MPO) activity were measured in the prefrontal cortex, hippocampus, and spinal cord samples. The clinical score increased 14th post‐immunization without changes in weight and mobility. Reduced paw strength, mechanical allodynia, and cold allodynia increased in the PMS‐EAE animals. PMS‐EAE mice showed spontaneous nociception and anxiety‐like behavior. AOPPs concentration, NADPH oxidase, and MPO activity increase in CNS structures. Multivariate analyses indicated that the rise of AOPPs levels, NADPH oxidase, and MPO activity influenced the clinical score and cold allodynia. Thus, we indicated the association between non‐stimuli painful perception, anxiety‐like, and CNS oxidative damage in the PMS‐EAE model. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Hydroalcoholic extract of leaf of Arachis hypogaea L. (Fabaceae) did not induce toxic effects in the repeated-dose toxicity study in rats

Author

Cossetin, Jocelene Filippin, de Almeida, Amanda Spring, Antoniazzi, Caren Tatiane de David, Kudsi, Sabrina Qader, Engelmann, Ana Martiele, Guex, Camille Gaube, de Oliveira, Juliana Sorraila, Theisen, Maria Carolina, Ritter, Camila Santos, Doleski, Pedro Henrique, Brum, Evelyne da Silva, Dalenogare, Diéssica Padilha, Peres, Diulle Spat, Pintos, Francieli Guedes, de Andrade, Cinthia Melazzo, Leal, Daniela Bitencourt Rosa, Oliveira, Sara Marchesan, Bauermann, Liliane de Freitas, Riéffel, Roberta Cougo, Sagrillo, Michele Rorato, Machado, Alencar Kolinski, Santos, Adair Roberto Soares, and Trevisan, Gabriela

Published
2020
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9. TRPA1 involvement in depression- and anxiety-like behaviors in a progressive multiple sclerosis model in mice

Author

Peres, Diulle Spat, primary, Theisen, Maria Carolina, additional, Fialho, Maria Fernanda Pessano, additional, Dalenogare, Diéssica Padilha, additional, Rodrigues, Patrícia, additional, Kudsi, Sabrina Qader, additional, Bernardes, Laura de Barros, additional, Ruviaro da Silva, Náthaly Andrighetto, additional, Lückemeyer, Débora Denardin, additional, Sampaio, Tuane Bazanella, additional, Pereira, Gabriele Cheiran, additional, Mello, Fernanda Kulinski, additional, Ferreira, Juliano, additional, Bochi, Guilherme Vargas, additional, Oliveira, Sara Marchesan, additional, de David Antoniazzi, Caren Tatiane, additional, and Trevisan, Gabriela, additional

Published
2021
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11. Characterisation of nociception and inflammation observed in a traumatic muscle injury model in rats

Author

Kudsi, Sabrina Qader, primary, Antoniazzi, Caren Tatiane de David, additional, Camponogara, Camila, additional, Brum, Evelyne da Silva, additional, Brusco, Indiara, additional, Peres, Diulle Spat, additional, Fischer, Susana Paula Moreira, additional, Dalenogare, Diéssica Padilha, additional, Stein, Carolina dos Santos, additional, Zaccaron, Rubya Pereira, additional, Silveira, Paulo Cesar Lock, additional, Moresco, Rafael Noal, additional, Oliveira, Sara Marchesan, additional, and Trevisan, Gabriela, additional

Published
2020
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12. TRPA1 activation mediates nociception behaviors in a mouse model of relapsing-remitting experimental autoimmune encephalomyelitis

Author

Dalenogare, Diéssica Padilha, primary, Theisen, Maria Carolina, additional, Peres, Diulle Spat, additional, Fialho, Maria Fernanda Pessano, additional, Lückemeyer, Débora Denardin, additional, Antoniazzi, Caren Tatiane de David, additional, Kudsi, Sabrina Qader, additional, Ferreira, Marcella de Amorim, additional, Ritter, Camila dos Santos, additional, Ferreira, Juliano, additional, Oliveira, Sara Marchesan, additional, and Trevisan, Gabriela, additional

Published
2020
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13. Effects of nanocapsules containing all-trans-retinoic acid under hemolytic and coagulation activity

Author

Sousa Filho, Walter Paixão de, primary, Homrich, Shayenne Schaeffer, additional, Copetti, Priscila Marquezan, additional, Peres, Diulle Spat, additional, Souza, Diulie Valente de, additional, Riéffel, Roberta Cougo, additional, Machado, Alencar Kolinski, additional, Ourique, Aline Ferreira, additional, and Sagrillo, Michele Rorato, additional

Published
2019
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