273 results on '"Pereira de Almeida, Luís"'
Search Results
2. Exploring the potential of cell-derived vesicles for transient delivery of gene editing payloads
3. Blood and cerebellar abundance of ATXN3 splice variants in spinocerebellar ataxia type 3/Machado-Joseph disease
4. RNA-based liposomes for oral cancer: From biophysical characterization to biological evaluation
5. A new protocol for whole-brain biodistribution analysis of AAVs by tissue clearing, light-sheet microscopy and semi-automated spatial quantification
6. Extracellular communication between brain cells through functional transfer of Cre mRNA mediated by extracellular vesicles
7. Extracellular vesicle-based delivery of silencing sequences for the treatment of Machado-Joseph disease/spinocerebellar ataxia type 3
8. Using genetically modified extracellular vesicles as a non-invasive strategy to evaluate brain-specific cargo
9. miRNA-31 Improves Cognition and Abolishes Amyloid-β Pathology by Targeting APP and BACE1 in an Animal Model of Alzheimer’s Disease
10. Modelling Lysosomal Storage Disorders in an innovative way: Establishment and Characterization of Stem Cell Lines from Human Exfoliated Deciduous Teeth of Mucopolysaccharidoses Type II Patients
11. Neuropeptide Y (NPY) intranasal delivery alleviates Machado–Joseph disease
12. Modeling Lysosomal Storage Disorders in an Innovative Way: Establishment and Characterization of Stem Cell Lines from Human Exfoliated Deciduous Teeth of Mucopolysaccharidosis Type II Patients.
13. Stage‐dependent biomarker changes in spinocerebellar ataxia type 3
14. List of Contributors
15. Gene editing and central nervous system regeneration
16. Extracellular vesicles: Novel promising delivery systems for therapy of brain diseases
17. Unravelling Endogenous MicroRNA System Dysfunction as a New Pathophysiological Mechanism in Machado-Joseph Disease
18. Unraveling the Role of Ataxin-2 in Metabolism
19. The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples
20. Trehalose alleviates the phenotype of Machado–Joseph disease mouse models
21. In Vitro Evaluation of Biphasic Calcium Phosphate Scaffolds Derived from Cuttlefish Bone Coated with Poly(ester urea) for Bone Tissue Regeneration
22. Gene therapy for the CNS using AAVs: The impact of systemic delivery by AAV9
23. Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype
24. MicroRNAs in Obesity and Metabolism
25. MiR-186-5p inhibition restores synaptic transmission and neuronal network activity in a model of chronic stress
26. Extracellular communication between brain cells through functional transfer of Cre mRNA
27. Ataxin-2 in the hypothalamus at the crossroads between metabolism and clock genes
28. MiRNA-21 silencing mediated by tumor-targeted nanoparticles combined with sunitinib: A new multimodal gene therapy approach for glioblastoma
29. The stress granule protein G3BP1 alleviates spinocerebellar ataxia-associated deficits
30. Let-7 Coordinately Suppresses Components of the Amino Acid Sensing Pathway to Repress mTORC1 and Induce Autophagy
31. Differential Temporal Dynamics of Axial and Appendicular Ataxia in SCA3
32. SIRT2 Deficiency Exacerbates Hepatic Steatosis via a Putative Role of the ER Stress Pathway
33. Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia
34. ULK overexpression mitigates motor deficits and neuropathology in mouse models of Machado-Joseph disease
35. IGF-1 Intranasal Administration Rescues Huntington's Disease Phenotypes in YAC128 Mice
36. Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado–Joseph disease
37. Extracellular Vesicles Physiological Role and the Particular Case of Disease-Spreading Mechanisms in Polyglutamine Diseases
38. Characterization of Lifestyle in Spinocerebellar Ataxia Type 3 and Association with Disease Severity
39. The autophagy‐enhancing drug carbamazepine improves neuropathology and motor impairment in mouse models of Machado–Joseph disease
40. Highly Specific Blood-Brain Barrier Transmigrating Single-Domain Antibodies Selected by an In Vivo Phage Display Screening
41. Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado–Joseph disease
42. Transplantation of cerebellar neural stem cells improves motor coordination and neuropathology in Machado-Joseph disease mice
43. Identification of the calpain‐generated toxic fragment of ataxin‐3 protein provides new avenues for therapy of Machado–Joseph disease| Spinocerebellar ataxia type 3
44. Living Proof of Activity of Extracellular Vesicles in the Central Nervous System
45. Calpain inhibition reduces ataxin-3 cleavage alleviating neuropathology and motor impairments in mouse models of Machado–Joseph disease
46. Chapter 11 - Gene editing and central nervous system regeneration
47. Impact of SAPAP3 on mitochondrial function in Huntington’s disease
48. Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado–Joseph disease
49. MicroRNA-21 silencing enhances the cytotoxic effect of the antiangiogenic drug sunitinib in glioblastoma
50. Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado–Joseph disease
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