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Your search keyword '"Pereira, Valéria R.A."' showing total 19 results
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19 results on '"Pereira, Valéria R.A."'

6. Thiosemicarbazones as Aedes aegypti larvicidal

Author

da Silva, João Bosco P., Navarro, Daniela Maria do A.F., da Silva, Aluizio G., Santos, Geanne K.N., Dutra, Kamilla A., Moreira, Diogo Rodrigo, Ramos, Mozart N., Espíndola, José Wanderlan P., de Oliveira, Ana Daura T., Brondani, Dalci José, Leite, Ana Cristina L., Hernandes, Marcelo Zaldini, Pereira, Valéria R.A., da Rocha, Lucas F., de Castro, Maria Carolina A.B., de Oliveira, Beatriz C., Lan, Que, and Merz, Kenneth M., Jr.

Published
2015
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11. Performance evaluation of anti-fixed Leishmania infantum promastigotes immunoglobulin G (IgG) detected by flow cytometry as a diagnostic tool for visceral Leishmaniasis

Author

Silva, Elis D., primary, Oliveira, Beatriz C., additional, Oliveira, Andresa P., additional, Santos, Wagner J.T., additional, Diniz, George T., additional, de Melo Neto, Osvaldo P., additional, Costa, Carlos H.N., additional, Silva, Mauro R.B., additional, Andrade, Luiz D., additional, Medeiros, Zulma M., additional, and Pereira, Valéria R.A., additional

Published
2019
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12. Antitumor and immunomodulatory activities of thiosemicarbazones and 1,3-Thiazoles in Jurkat and HT-29 cells

Author

dos Santos, Thiago André R., primary, da Silva, Aline Caroline, additional, Silva, Elany Barbosa, additional, Gomes, Paulo André Teixeira de Moraes, additional, Espíndola, José Wanderlan Pontes, additional, Cardoso, Marcos Veríssimo de Oliveira, additional, Moreira, Diogo Rodrigo Magalhaes, additional, Leite, Ana Cristina Lima, additional, and Pereira, Valéria R.A., additional

Published
2016
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13. Induction of cancer cell death by apoptosis and slow release of 5-fluoracil from metal-organic frameworks Cu-BTC

Author

Lucena, Flávia Raquel Santos, Araújo, Larissa C.C. de, Rodrigues, Maria do D., Silva, Teresinha G. da, Pereira, Valéria R.A., Militão, Gardênia C.G., Fontes, Danilo A.F., Rolim-Neto, Pedro J., Silva, Fausthon F. da, and Nascimento, Silene C.

Subjects
Apoptose, Morte Celular, Cancro
Abstract

This study aimed to evaluate the mechanism associated with cytotoxic activity displayed by the drug 5- fluorouracil incorporated in Cu-BTC MOF and its slow delivery from the Cu-BTC MOF. Structural characterization encompasses elemental analysis (CHNS), differential scanning calorimetry (DSC), thermogravimetric analysis (TG/DTG), Fournier transform infrared (FIT-IR) and X-ray diffraction (XRD) was performed to verify the process of association between the drug 5-FU and Cu-BTC MOF. Flow cytometry was done to indicate that apoptosis is the mechanism responsible for the cell death. The release profile of the drug 5-FU from Cu-BTC MOF for 48 hours was obeisant. Also, the anti-inflammatory activity was evaluated by the peritonitis testing and the production of nitric oxide and pro-inflammatory cytokines were measured. The chemical characterization of the material indicated the presence of drug associated with the coordination network in a proportion of 0.82 g 5-FU per 1.0 g of Cu-BTC MOF. The cytotoxic tests were carried out against four cell lines: NCI-H292, MCF-7, HT29 and HL60. The Cu-BTC MOF associated drug was extremely cytotoxic against the human breast cancer adenocarcinoma (MCF- 7) cell line and against human acute promyelocytic leukemia cells (HL60), cancer cells were killed by apoptosis mechanisms. The drug demonstrated a slow release profile where 82% of the drug was released in 48 hours. The results indicated that the drug incorporated in Cu-BTC MOF decreased significantly the number of leukocytes in the peritoneal cavity of rodents as well as reduced levels of cytokines and nitric oxide production.

Published
2013

14. Induction of cancer cell death by apoptosis and slow release of 5-fluoracil from metal-organic frameworks Cu-BTC

Author

Lucena, Flávia Raquel Santos, primary, de Araújo, Larissa C.C., additional, Rodrigues, Maria do D., additional, da Silva, Teresinha G., additional, Pereira, Valéria R.A., additional, Militão, Gardênia C.G., additional, Fontes, Danilo A.F., additional, Rolim-Neto, Pedro J., additional, da Silva, Fausthon F., additional, and Nascimento, Silene C., additional

Published
2013
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16. Cellular immune response from chagasic patients to CRA or FRA recombinant antigens ofTrypanosoma cruzi

Author

Lorena, Virginia M.B., primary, Verçosa, Alinne F.A., additional, Machado, Raquel C.A., additional, Moitinho‐Silva, Lucas, additional, Cavalcanti, Maria G.A., additional, Silva, Edimilson D., additional, Ferreira, Antonio G.P., additional, Correa‐Oliveira, Rodrigo, additional, Pereira, Valéria R.A., additional, and Gomes, Yara M., additional

Published
2008
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