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1. Evidence of Zika Virus Reinfection by Genome Diversity and Antibody Response Analysis, Brazil

Author

Castilho, Marcia da Costa, de Filippis, Ana Maria Bispo, Machado, Lais Ceschini, de Lima Calvanti, Thaise Yasmine Vasconcelos, Lima, Morganna Costa, Fonseca, Vagner, Giovanetti, Marta, Docena, Cassia, Neto, Armando Menezes, Botto-Menezes, Camila Helena Aguiar, Kara, Edna Oliveira, de La Barrera, Rafael, Modjarrad, Kayvon, Giozza, Silvana Pereira, Pereira, Gerson Fernando, Alcantara, Luiz Carlos Junior, Broutet, Nathalie Jeanne Nicole, Calvet, Guilherme Amaral, Wallau, Gabriel Luz, and Franca, Rafael Freitas Oliveira

Subjects
Diagnosis, Genetic aspects, Recurrence (Disease) -- Genetic aspects -- Diagnosis, Zika virus infection -- Genetic aspects -- Diagnosis, Diseases -- Relapse
Abstract

Zika virus (ZIKV) is an arthropodborne virus belonging to the Flaviviridae family. Virions are enveloped for a single-stranded positive-sense RNA genome of [approximately equal to]10.8-kb (1). ZIKV is transmitted through [...]

Published
2024
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2. Detection and persistence of Zika virus in body fluids and associated factors: a prospective cohort study

Author

Calvet, Guilherme Amaral, Kara, Edna Oliveira, Bôtto-Menezes, Camila Helena Aguiar, da Costa Castilho, Marcia, de Oliveira Franca, Rafael Freitas, Habib, Ndema, Neto, Armando Menezes, Pereira, Gerson Fernando Mendes, Giozza, Silvana Pereira, Bermúdez, Ximena Pamela Díaz, Fernandes, Tatiana Jorge, Modjarrad, Kayvon, Brasil, Patrícia, Broutet, Nathalie Jeanne Nicole, and de Filippis, Ana Maria Bispo

Published
2023
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4. Accuracy of capillary blood sampling for diagnosing syphilis infection.

Author

dos Santos, Aniúsca Vieira, da Rocha, Ana Carolina Monteiro, dos Santos, Giovana Tavares, Vieira, Igor Araujo, de Oliveira, Cáren Nunes, Basgalupp, Suelen, Pedrotti, Luana Giongo, Roglio, Vinicius Serafini, de Brito, Emerson Silveira, Dornelles, Thayane Martins, Pereira, Gerson Fernando Mendes, de Souza, Flávia Moreno Alves, and Wendland, Eliana Marcia

Subjects
BLOOD collection, SERODIAGNOSIS, SYPHILIS, BLOOD sampling, DEVELOPING countries
Abstract

Capillary blood collection presents advantages such as reduced invasiveness over venous serum for syphilis diagnosing. This study aimed to compare diagnostic accuracy between capillary and venous blood samples for syphilis diagnosis. Individuals aged ≥ 18 years were included in a cross-sectional study. Syphilis screening was done using Rapid tests (RT) followed by collection of serum capillary and venous samples for VDRL and TPHA test. Sensitivity, specificity, and Kappa coefficient were calculated. Of 191 participants, 115 RT + and 76 RT-. Diagnostic properties did not significantly differ between capillary and venous samples. Capillary VDRL showed 99% sensitivity and 100% specificity, mirroring TPHA results. Furthermore, there was significant agreement between sample types for both serological tests (p < 0.001). Capillary sampling offers comparable diagnostic accuracy to venous collection, regardless of serum quality. Capillary sampling holds promise, particularly in developing countries and large-scale testing initiatives. [ABSTRACT FROM AUTHOR]

Published
2025
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11. Dolutegravir and pregnancy outcomes in women on antiretroviral therapy in Brazil: a retrospective national cohort study

Author

Pereira, Gerson Fernando Mendes, Kim, Ahra, Jalil, Emilia M, Fernandes Fonseca, Fernanda, Shepherd, Bryan E, Veloso, Valdilea G, Rick, Fernanda, Ribeiro, Rachel, Pimenta, Maria Cristina, Beber, Andrea, Corrêa, Renato Girade, Lima, Renato, Maruri, Fernanda, McGowan, Catherine C, Schwartz Benzaken, Adele, Grinsztejn, Beatriz, and Castilho, Jessica L

Published
2021
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12. Comparative evaluation of HPV genotyping: A study on the performance concordance between Anyplex II HPV28 detection and Linear Array genotyping tests in nationwide studies in Brazil

Author

Bandeira, Isabel Cristina, primary, Comerlato, Juliana, additional, Bessel, Marina, additional, Fernandes, Bruna Vieira, additional, Mota, Giana, additional, Villa, Luisa Lina, additional, de Souza, Flávia Moreno Alves, additional, Pereira, Gerson Fernando Mendes, additional, and Wendland, Eliana Marcia, additional

Published
2024
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14. Recent dynamics in Neisseria gonorrhoeae genomic epidemiology in Brazil : antimicrobial resistance and genomic lineages in 2017-20 compared to 2015-16

Author

Golparian, Daniel, Bazzo, Maria Luiza, Ahlstrand, Josefine, Schörner, Marcos André, Gaspar, Pamela Cristina, Machado, Hanalydia de Melo, Martins, Jéssica Motta, Bigolin, Alisson, Ramos, Mauro Cunha, Ferreira, William Antunes, Pereira, Gerson Fernando Mendes, Miranda, Angelica Espinosa, Unemo, Magnus, Golparian, Daniel, Bazzo, Maria Luiza, Ahlstrand, Josefine, Schörner, Marcos André, Gaspar, Pamela Cristina, Machado, Hanalydia de Melo, Martins, Jéssica Motta, Bigolin, Alisson, Ramos, Mauro Cunha, Ferreira, William Antunes, Pereira, Gerson Fernando Mendes, Miranda, Angelica Espinosa, and Unemo, Magnus

Abstract

OBJECTIVES: Regular quality-assured WGS with antimicrobial resistance (AMR) and epidemiological data of patients is imperative to elucidate the shifting gonorrhoea epidemiology, nationally and internationally. We describe the dynamics of the gonococcal population in 11 cities in Brazil between 2017 and 2020 and elucidate emerging and disappearing gonococcal lineages associated with AMR, compare to Brazilian WGS and AMR data from 2015 to 2016, and explain recent changes in gonococcal AMR and gonorrhoea epidemiology. METHODS: WGS was performed using Illumina NextSeq 550 and genomes of 623 gonococcal isolates were used for downstream analysis. Molecular typing and AMR determinants were obtained and links between genomic lineages and AMR (determined by agar dilution/Etest) examined. RESULTS: Azithromycin resistance (15.6%, 97/623) had substantially increased and was mainly explained by clonal expansions of strains with 23S rRNA C2611T (mostly NG-STAR CC124) and mtr mosaics (mostly NG-STAR CC63, MLST ST9363). Resistance to ceftriaxone and cefixime remained at the same levels as in 2015-16, i.e. at 0% and 0.2% (1/623), respectively. Regarding novel gonorrhoea treatments, no known zoliflodacin-resistance gyrB mutations or gepotidacin-resistance gyrA mutations were found. Genomic lineages and sublineages showed a phylogenomic shift from sublineage A5 to sublineages A1-A4, while isolates within lineage B remained diverse in Brazil. CONCLUSIONS: Azithromycin resistance, mainly caused by 23S rRNA C2611T and mtrD mosaics/semi-mosaics, had substantially increased in Brazil. This mostly low-level azithromycin resistance may threaten the recommended ceftriaxone-azithromycin therapy, but the lack of ceftriaxone resistance is encouraging. Enhanced gonococcal AMR surveillance, including WGS, is imperative in Brazil and other Latin American and Caribbean countries., This study was supported by the Örebro County Council Research Committee (2021) and the Foundation for Medical Research at Örebro University Hospital (2020), Örebro, Sweden and the Brazilian Ministry of Health, through its Secretariat for Health Surveillance and its Department of Chronic Conditions and Sexually Transmitted Infection (2017-2020).

Published
2024
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16. Hepatitis C disease burden and strategies for elimination by 2030 in Brazil. A mathematical modeling approach

Author

Benzaken, Adele Schwartz, Girade, Renato, Catapan, Elisa, Pereira, Gerson Fernando Mendes, Almeida, Elton Carlos de, Vivaldini, Simone, Fernandes, Neide, Razavi, Homie, Schmelzer, Jonathan, Ferraz, Maria Lucia, Ferreira, Paulo Roberto Abrão, Pessoa, Mario Guimarães, Martinelli, Ana, Souto, Francisco José Dutra, Walsh, Nick, and Mendes-Correa, Maria Cassia

Published
2019
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19. Evidence of Zika Virus Reinfection by Genome Diversity and Antibody Response Analysis, Brazil

Author

da Costa Castilho, Marcia, primary, de Filippis, Ana Maria Bispo, additional, Machado, Lais Ceschini, additional, de Lima Calvanti, Thaise Yasmine Vasconcelos, additional, Lima, Morganna Costa, additional, Fonseca, Vagner, additional, Giovanetti, Marta, additional, Docena, Cassia, additional, Neto, Armando Menezes, additional, Bôtto-Menezes, Camila Helena Aguiar, additional, Kara, Edna Oliveira, additional, de La Barrera, Rafael, additional, Modjarrad, Kayvon, additional, Giozza, Silvana Pereira, additional, Pereira, Gerson Fernando, additional, Alcantara, Luiz Carlos Junior, additional, Broutet, Nathalie Jeanne Nicole, additional, Calvet, Guilherme Amaral, additional, Wallau, Gabriel Luz, additional, and Franca, Rafael Freitas Oliveira, additional

Published
2024
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22. Comparison of cumulative viraemia following treatment initiation with different antiretroviral regimens: a real-life study in Brazil

Author

Pascom, Ana R., Pinho, Rosana E.G.G., Rick, Fernanda, Veras, Nazle M.C., de Barros Perini, Filipe, Meireles, Mariana V., Pereira, Gerson F., Benzaken, Adele S., and Avelino-Silva, Vivian I.

Subjects
Comparative analysis, Efavirenz -- Comparative analysis, Highly active antiretroviral therapy -- Comparative analysis, Lamivudine -- Comparative analysis, Atazanavir -- Comparative analysis, Dolutegravir -- Comparative analysis, Patient compliance -- Comparative analysis, Medical research -- Comparative analysis, Virus diseases -- Comparative analysis
Abstract

1 | INTRODUCTION The relative efficacy of different antiretroviral treatment (ART) regimens has been extensively evaluated in the context of clinical trials [1-3]. Nevertheless, real-life studies may still contribute with [...], Introduction: The relative efficacy of different antiretroviral (ART) regimens has been extensively evaluated in the context of clinical trials, using HIV viral load (VL) measurements at pre-specified timepoints after ART onset. However, data from real-life studies using combined longitudinal measurements of cumulative viraemia are scarce. This study aimed to address the independent effect of different ART regimens on HIV cumulative viraemia over the first 12 months after treatment initiation, using programmatic data from the Ministry of Health of Brazil. Methods: Retrospective cohort study analysing cumulative viraemia under the most frequently used ART regimens in Brazi (tenofovir, lamivudine and dolutegravir (regimen 1); tenofovir, lamivudine and efavirenz (regimen 2); tenofovir, lamivudine and ritonavir-boosted atazanavir (regimen 3)). Results and Discussion: We included 112,243 patients >12 years old who received their first ART prescription between January 2014 and August 2017. Univariate analysis indicated that cumulative viraemia was significantly lower in patients receiving regimen 1 as compared with those receiving regimens 2 or 3 (p Conclusions: Our findings could bring direct benefits to patients as suggested by lower viral replication during treatment, lower risk of HIV transmission, and a potential reduction in resistance mutations in the initial 12 months under ART. Keywords: HIV; antiretroviral treatment; cumulative viremia; efficacy; antiretroviral regimen; real-life

Published
2019
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25. Phase II trial evaluating the clinical efficacy of cefixime for treatment of active syphilis in non-pregnant women in Brazil (CeBra)

Author

Taylor, Melanie M., Kara, Edna Oliveira, Araujo, Maria Alix Leite, Silveira, Mariangela Freitas, Miranda, Angelica Espinosa, Branco Coelho, Ivo Castelo, Bazzo, Maria Luiza, Mendes Pereira, Gerson Fernando, Pereira Giozza, Silvana, Bermudez, Ximena Pamela Díaz, Mello, Maeve B., Habib, Ndema, Nguyen, My Huong, Thwin, Soe Soe, and Broutet, Nathalie

Published
2020
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29. Perspectives and challenges for mother-to-child transmission of HIV, hepatitis B, and syphilis in Brazil

Author

Miranda, Angelica E., primary, Santos, Patricia C., additional, Coelho, Ronaldo A., additional, Pascom, Ana Roberta P., additional, de Lannoy, Leonor Henriette, additional, Ferreira, Ana Cristina Garcia, additional, Gaspar, Pamela Cristina, additional, Maciel, Ethel Leonor, additional, Barreira, Draurio, additional, and Pereira, Gerson Fernando Mendes, additional

Published
2023
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33. O ENSINO RELIGIOSO COMO PROPOSTA DE EDUCAÇÃO INTERCULTURAL E POSSIBILIDADES DE COMBATE À INTOLERÂNCIA RELIGIOSA NA BAIXADA FLUMINENSE

Author

Pereira, Gerson Lourenço and Pereira, Gerson Lourenço

Abstract

Dentre variados setores desafiados, a Educação Básica, oferecida pelas escolas públicas municipais e estaduais, pode ser instada a desempenhar um papel primordial no combate a toda forma de discriminação e intolerância, contribuindo de maneira fundamental para a construção de uma cultura de paz e particular na Baixada Fluminense, no estado do Rio de Janeiro, cenário de múltiplas necessidades e desafios políticos e sociais. Mas, de que tipo de educação e prática educativa ter-se-ia em vista para esse fim? Haveria uma área de conhecimento e/ou componente curricular que viabilizasse essa construção? O entendimento do presente artigo é que a educação praticada em perspectiva intercultural, conforme a Base Nacional Comum Curricular (BNCC) preconiza em relação a Área de Conhecimento e Componente Curricular do Ensino Religioso, atenderia esse propósito junto às redes públicas de educação da região. Um ensino calcado no princípio democrático, na tolerância e consciência cidadã no contexto da Baixada Fluminense. PALAVRAS-CHAVE: Educação intercultural. Ensino religioso. Baixada Fluminense. Tolerância religiosa. Cultura de paz., Among several challenged sectors, Basic Education, offered by municipal and state public schools, can be urged to play a key role in combating all forms of discrimination and intolerance, contributing in a fundamental way to the construction of a culture of peace and particularly in Baixada Fluminense, in the state of Rio de Janeiro, a scenario of multiple needs and political and social challenges. But, what kind of education and educational practice would one have in mind for this purpose? Would there be an area of knowledge and/or curricular component that would make this construction possible? The understanding of this article is that education practiced in an intercultural perspective, as recommended by the National Common Curricular Base (NCCB) in relation to the Area of Knowledge and Curriculum Component of Religious Education, would serve this purpose together with the public education networks in the region. Teaching based on the democratic principle, tolerance and citizen awareness in the context of Baixada Fluminense. KEYWORDS: Intercultural education. Religious education. Baixada Fluminense. Religious tolerance. Culture of peace. &nbsp

Published
2023

34. Additional file 5 of Impact of pre-exposure prophylaxis uptake among gay, bisexual, and other men who have sex with men in urban centers in Brazil: a modeling study

Author

Luz, Paula M., Deshpande, Vijeta, Kazemian, Pooyan, Scott, Justine A., Shebl, Fatma M., Spaeth, Hailey, Pimenta, Cristina, Stern, Madeline, Pereira, Gerson, Struchiner, Claudio J., Grinsztejn, Beatriz, Veloso, Valdilea G., and Freedberg, Kenneth A.

Abstract

Additional file 5. Derivation of inputs for ART adherence, DTG-associated viral suppression, and late failure.

Published
2023
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35. Additional file 1 of Impact of pre-exposure prophylaxis uptake among gay, bisexual, and other men who have sex with men in urban centers in Brazil: a modeling study

Author

Luz, Paula M., Deshpande, Vijeta, Kazemian, Pooyan, Scott, Justine A., Shebl, Fatma M., Spaeth, Hailey, Pimenta, Cristina, Stern, Madeline, Pereira, Gerson, Struchiner, Claudio J., Grinsztejn, Beatriz, Veloso, Valdilea G., and Freedberg, Kenneth A.

Abstract

Additional file 1. Indirect community benefit.

Published
2023
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36. Additional file 4 of Impact of pre-exposure prophylaxis uptake among gay, bisexual, and other men who have sex with men in urban centers in Brazil: a modeling study

Author

Luz, Paula M., Deshpande, Vijeta, Kazemian, Pooyan, Scott, Justine A., Shebl, Fatma M., Spaeth, Hailey, Pimenta, Cristina, Stern, Madeline, Pereira, Gerson, Struchiner, Claudio J., Grinsztejn, Beatriz, Veloso, Valdilea G., and Freedberg, Kenneth A.

Abstract

Additional file 4. CEPAC modules: HIV natural history and Antiretroviral therapy regimens.

Published
2023
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37. Additional file 2 of Impact of pre-exposure prophylaxis uptake among gay, bisexual, and other men who have sex with men in urban centers in Brazil: a modeling study

Author

Luz, Paula M., Deshpande, Vijeta, Kazemian, Pooyan, Scott, Justine A., Shebl, Fatma M., Spaeth, Hailey, Pimenta, Cristina, Stern, Madeline, Pereira, Gerson, Struchiner, Claudio J., Grinsztejn, Beatriz, Veloso, Valdilea G., and Freedberg, Kenneth A.

Abstract

Additional file 2. CEPAC module: transmission network.

Published
2023
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38. Additional file 3 of Impact of pre-exposure prophylaxis uptake among gay, bisexual, and other men who have sex with men in urban centers in Brazil: a modeling study

Author

Luz, Paula M., Deshpande, Vijeta, Kazemian, Pooyan, Scott, Justine A., Shebl, Fatma M., Spaeth, Hailey, Pimenta, Cristina, Stern, Madeline, Pereira, Gerson, Struchiner, Claudio J., Grinsztejn, Beatriz, Veloso, Valdilea G., and Freedberg, Kenneth A.

Abstract

Additional file 3. Estimating HIV incidence rate by city.

Published
2023
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42. Certificação subnacional da eliminação da transmissão vertical de HIV e/ou sífilis: relato da experiência brasileira

Author

Miranda, Angélica Espinosa, primary, Gaspar, Pâmela Cristina, additional, Lannoy, Leonor Henriette de, additional, Guarabyra, Aranaí Sampaio Diniz, additional, Souto, Rayone Moreira Costa Veloso, additional, Pereira, Esdras Daniel dos Santos, additional, Pereira, Gerson Fernando, additional, Dias, Guilherme Borges, additional, Domingues, Carmen Silvia Bruniera, additional, Lima, Aparecida Morais, additional, Matos, Ariane Tiago Bernardo de, additional, Oliveira, Maria da Guia de, additional, Aragón, Mayra Gonçalves, additional, Machado, Nádia Maria da Silva, additional, Aires Junior, Luíz Fernando, additional, Souza, Isabella Mayara Diana de, additional, Maciel, Ethel Leonor, additional, and Barreira, Draurio, additional

Published
2023
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44. Detection of HPV DNA in vaginal samples self-collected by women living with HIV treated through the Brazilian public health system: Prevalence and analysis of risk factors

Author

Silveira, Mariângela Freitas da, primary, Buffarini, Romina, additional, Gaspar, Pâmela Cristina, additional, Machado, Hanalydia de Melo, additional, Bazzo, Maria Luiza, additional, Scherer, Aline, additional, Colusso, Álvaro Luis, additional, Travassos, Ana Gabriela Álvares, additional, Arakaki-Sanchez, Denise, additional, Baia-da-Silva, Djane Clarys, additional, Oliveira, Eduardo Campos de, additional, Zago, Isabella Ribeiro, additional, Moura, Marcos de Assis, additional, Lacerda, Marcus Vinicius Guimarães de, additional, Martins, Simone Murta, additional, Reuter, Tânia, additional, Pinto, Valdir Monteiro, additional, Perini, Waltesia, additional, Pereira, Gerson Fernando Mendes, additional, and Miranda, Angélica Espinosa, additional

Published
2023
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45. Certificación subnacional de la eliminación de la trasmisión vertical de VIH y/o sífilis: relato de la experiencia brasileña

Author

Miranda, Angélica Espinosa, primary, Gaspar, Pâmela Cristina, additional, Lannoy, Leonor Henriette de, additional, Guarabyra, Aranaí Sampaio Diniz, additional, Souto, Rayone Moreira Costa Veloso, additional, Pereira, Esdras Daniel dos Santos, additional, Pereira, Gerson Fernando, additional, Dias, Guilherme Borges, additional, Domingues, Carmen Silvia Bruniera, additional, Lima, Aparecida Morais, additional, Matos, Ariane Tiago Bernardo de, additional, Oliveira, Maria da Guia de, additional, Aragón, Mayra Gonçalves, additional, Machado, Nádia Maria da Silva, additional, Aires Junior, Luíz Fernando, additional, Souza, Isabella Mayara Diana de, additional, Maciel, Ethel Leonor, additional, and Barreira, Draurio, additional

Published
2023
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47. Subnational certification of elimination of mother-to-child transmission of HIV and/or syphilis: a Brazilian experience report

Author

Miranda, Angélica Espinosa, primary, Gaspar, Pâmela Cristina, additional, Lannoy, Leonor Henriette de, additional, Guarabyra, Aranaí Sampaio Diniz, additional, Souto, Rayone Moreira Costa Veloso, additional, Pereira, Esdras Daniel dos Santos, additional, Pereira, Gerson Fernando, additional, Dias, Guilherme Borges, additional, Domingues, Carmen Silvia Bruniera, additional, Lima, Aparecida Morais, additional, Matos, Ariane Tiago Bernardo de, additional, Oliveira, Maria da Guia de, additional, Aragón, Mayra Gonçalves, additional, Machado, Nádia Maria da Silva, additional, Aires Junior, Luíz Fernando, additional, Souza, Isabella Mayara Diana de, additional, Maciel, Ethel Leonor, additional, and Barreira, Draurio, additional

Published
2023
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