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1. Electrochemical Halogenation of Naphthoquinones: A Modular and Sustainable Strategy Towards Trypanocidal Compounds.

Author

Guimarães, Eduardo F. S., Graça, Gabriela A. P., Diogo, Emilay B. T., Almeida, Renata G., Pereira, Daiane B., Araujo, Maria H., da Silva, Caren D. G., Gatto, Claudia C., Ramos, Victor F. S., Menna‐Barreto, Rubem F. S., Jardim, Guilherme A. M., and da Silva Júnior, Eufrânio N.

Subjects
CHAGAS' disease, PHARMACEUTICAL chemistry, HALOGENATION, DRUG marketing, DRUG utilization
Abstract

An eco‐friendly electrochemical halogenation of 2‐amino‐1,4‐naphthoquinones has been developed. The new mild and energy efficient methodology comprises sustainable features like oxidant free and double role of the halogen source as electrolyte, originating twenty‐six amino‐halogenated naphthoquinoidal derivatives in good yields under mild conditions. This novel methodology permitted access to new potent trypanocidal prototypes, where six compounds were more active than benznidazole, the current market drug used in the treatment of Chagas Disease. [ABSTRACT FROM AUTHOR]

Published
2024
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