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16 results on '"Pereira, Alana Kelyene"'

2. Musa spp. cultivars as a neutralising source against some toxic activities of Bothrops and Crotalus genus snake venoms

Author

Matos da Silva, Márcia, Pereira Alexandre, Gerso, Magalhães, Marta Regina, Torres, Ana Maria, Kato, Lucilia, Costa da Silva, Victória, Teixeira de Saboia Morais, Simone Maria, Garcia Rodriguez, Armando, Pacheco Fill, Taícia, Pereira, Alana Kelyene, Roque, Jussara, Souza Simão, Jorge Luiz, and Pasqualotto Severino, Vanessa Gisele

Published
2023
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5. Dereplication of polar extracts from Croton antisyphiliticus Mart. roots and its anti-inflammatory and antinociceptive potential.

Author

Simão, Jorge Luiz Souza, Prado, Stephanie Vilela, Pereira, Alana Kelyene, Alexandre, Gerso Pereira, Pires Gomide, Núbia Alves Mariano Teixeira, Matos da Silva, Marcia, Almeida, Dionys de Souza, Martins, Aline Nazareth, Bueno da Silva, Daiany Priscilla, Costa, Elson Alves da, and Pasqualotto Severino, Vanessa Gisele

Subjects
PLANT extracts, CROTON (Genus), LABORATORY mice, MYELOPEROXIDASE, MASS spectrometers, ANTIARTHRITIC agents, DEXAMETHASONE
Abstract

Croton antisyphiliticus Mart. is a plant popularly used in folk medicine by traditional communities from Brazilian savannah to treat general inflammation. According to ethnopharmacological data, this specie can be considered a source of biologically active molecules for the development of new drugs. Thereby, this study reports the results of the dereplication approach of C. antisyphiliticus roots extracts and the in vivo evaluation of its potential antinociceptive and anti-inflammatory in albino Swiss mice. Based on HPLC coupled to Q-Exactive Orbitrap Mass Spectrometer and using GNPS, a total of thirteen polyphenolic compounds were noticed, including four compounds that have been reported for the first time in the genus Croton. Ethanolic and aqueous roots extracts demonstrated a dose-dependent inhibition for the number of writes, reduced pain induced by formalin and hyperalgesia induced by carrageenan. These extracts also reduced paw edema, cell migration, and myeloperoxidase activity, with effects similar to indomethacin and dexamethasone drugs. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Traversing the Cell Wall: The Chitinolytic Activity of Histoplasma capsulatum Extracellular Vesicles Facilitates Their Release

Author

Valdez, Alessandro F., primary, de Souza, Taiane Nascimento, additional, Bonilla, Jhon Jhamilton Artunduaga, additional, Zamith-Miranda, Daniel, additional, Piffer, Alicia Corbellini, additional, Araujo, Glauber R. S., additional, Guimarães, Allan J., additional, Frases, Susana, additional, Pereira, Alana Kelyene, additional, Fill, Taicia Pacheco, additional, Estevao, Igor L., additional, Torres, Angel, additional, Almeida, Igor C., additional, Nosanchuk, Joshua D., additional, and Nimrichter, Leonardo, additional

Published
2023
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8. Dereplication of polar extracts from Croton antisyphiliticus Mart. roots and its anti-inflammatory and antinociceptive potential

Author

Simão, Jorge Luiz Souza, Prado, Stephanie Vilela, Pereira, Alana Kelyene, Alexandre, Gerso Pereira, Gomide, Núbia Alves Mariano Teixeira Pires, da Silva, Marcia Matos, de Souza Almeida, Dionys, Martins, Aline Nazareth, da Silva, Daiany Priscilla Bueno, da Costa, Elson Alves, and Severino, Vanessa Gisele Pasqualotto

Abstract

Croton antisyphiliticus Mart. is a plant popularly used in folk medicine by traditional communities from Brazilian savannah to treat general inflammation. According to ethnopharmacological data, this specie can be considered a source of biologically active molecules for the development of new drugs. Thereby, this study reports the results of the dereplication approach of C. antisyphiliticus roots extracts and the in vivo evaluation of its potential antinociceptive and anti-inflammatory in albino Swiss mice. Based on HPLC coupled to Q-Exactive Orbitrap Mass Spectrometer and using GNPS, a total of thirteen polyphenolic compounds were noticed, including four compounds that have been reported for the first time in the genus Croton. Ethanolic and aqueous roots extracts demonstrated a dose-dependent inhibition for the number of writes, reduced pain induced by formalin and hyperalgesia induced by carrageenan. These extracts also reduced paw edema, cell migration, and myeloperoxidase activity, with effects similar to indomethacin and dexamethasone drugs.

Published
2023
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10. Metabolomic analysis reveals stress tolerance mechanisms in common bean (Phaseolus vulgaris L.) related to treatment with a biostimulant obtained from Corynebacterium glutamicum

Author

da Silva, Stephanie Nemesio, primary, de Oliveira, Luis Fernando, additional, Repke, Rodrigo Alberto, additional, Pereira, Alana Kelyene, additional, Barbosa, Luidy Darlan, additional, Nunes, Rafael Leiria, additional, Sussulini, Alessandra, additional, Pinheiro, Fabio, additional, and Fill, Taicia Pacheco, additional

Published
2023
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12. GUIA PARA PROCESSAMENTO DE DADOS DE CROMATOGRAFIA ACOPLADA A ESPECTROMETRIA DE MASSAS

Author

Borges,Ricardo Moreira, Resende,João Victor Mendes, Moraes,Aldebaran Oliveira de, Pereira,Alana Kelyene, Garrett,Rafael, Bauermeister,Anelize, and Silva,Antonio Jorge Ribeiro da

Subjects
GC-MS, MZMine2, data processing, mass spectrometry, LC-MS
Abstract

In this work, a discussed and step-wise tutorial for LC-MS and GC-MS data processing using the open-access software MZMine2 is presented and discussed. The rationale behind each step was demonstrated to enable the readers to go through their own data and process it accordingly. The main lesson to be learned is that each parameter must be chosen in light of the raw data and no guidelines should suggest a predetermined value. Still, it is worth mentioning that ideal values for each parameter do not exist, and that the user might end up investing too much time futilely optimizing values. Our suggestion is to process your data in light of the raw data (and the study design) following the preview figure result and the resulting feature list generated in each processing step, interpret your data, and go back to process it again to tune the detection of important features.

Published
2022

15. Molecular networking as a tool to annotate the metabolites of Bacillussp. and Serratia marcescensisolates and evaluate their fungicidal effects against Magnapothe oryzaeand Bipolaris oryzae

Author

Arriel-Elias, Marina Teixeira, Pereira, Alana Kelyene, Arriel, Gabriel Carlos T. F., Alexandre, Gerso, de Andrade Bezerra, Gustavo, Fill, Taícia Pacheco, Severino, Vanessa Gisele Pasqualotto, and de Filippi, Marta Cristina Corsi

Abstract

Rhizobacteria are valuable sources of compounds that can be used for the integrated management of diseases in rice. Here, we aimed to explore the metabolism and organize and annotate the metabolites of Bacillus sp. and Serratia marcescensisolates using molecular networking and evaluate their fungicidal effects against Magnaporthe oryzaeand Bipolaris oryzae.We obtained bacterial extracts after 6 and 16-h incubation via liquid–liquid extraction using ethyl acetate as solvent. We performed UHPLC-MS analysis and data processing using molecular networking and conducted biological assays in rice plants. Using the Global Natural Product Social spectral libraries, we annotated the following compounds: austinoneol, Phe-Pro, N-acetyl-l-leucine, Leu-Gly, Ile-Leu, Phe-Pro, 2,5-piperazinedione, 3-(1H-indol-3-methyl)-6-methyl-cyclo(d-Trp-l-Pro), and cholic acid. Results of the biological assays showed that the bacterial extracts reduced the mycelial growth of both pathogens in all treatments compared to the control. In the greenhouse setup, 8 days after the challenge for leaf gray spot and leaf blast, all treatments affected up to 4.4% of the leaf area, with an area under disease progress curve of 13.24, showing significant difference compared to the control, which affected 23% of the leaf area, with an AUDPC of 44.65. Our study provides potential new sources of natural products to be applied in the integrated management of rice.

Published
2023
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16. Recovery and purification of bikaverin produced by Fusarium oxysporum CCT7620.

Author

Mendonça M, Santos MCD, Pereira AK, Fill TP, Forte MBS, and Bicas JL

Abstract

Microbial pigments have a distinguished potential for applications in food and pharmaceutical industries, stimulating the research in this field. The present study evaluated the ideal conditions for extracting bikaverin (red pigment) from the biomass of Fusarium oxysporum CCT7620. Among the solvents tested, ethyl acetate extraction resulted in the highest bikaverin concentration and the kinetic study revealed a saturation in bikaverin concentration from 256 min on. Based on a preliminary economic study, three sequential extractions with ethyl acetate was considered the ideal protocol to recover bikaverin. After extraction, chromatographic methods were tested to purify bikaverin. The use of silica gel or Sephadex (open column) could not successfully purify bikaverin, but the semi-preparative HPLC resulted in a bikaverin-enriched fraction with a purity degree equivalent to the commercial analytical standard. This work provides relevant information regarding the extraction and purification of bikaverin, which may be useful for other downstraming processes., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2021 The Author(s).)

Published
2021
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