Search

Your search keyword '"Perdue, Philip W"' showing total 17 results
Start Over Author "Perdue, Philip W"
17 results on '"Perdue, Philip W"'

5. Intestinal obstruction complicating pregnancy

Author

Perdue, Philip W., Johnson, Harry W., Jr., and Stafford, Perry W.

Subjects
Pregnancy, Complications of -- Care and treatment, Intestines -- Obstructions, Health
Published
1992

6. Metalloproteinase Expression is Associated with Traumatic Wound Failure

Author

NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD, Utz, Edward R, Elster, Eric A, Tadaki, Douglas K, Gage, Frederick, Perdue, Philip W, Forsberg, Jonathan A, Stojadinovic, Alexander, Hawksworth, Jason S, Brown, Trevor S, NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD, Utz, Edward R, Elster, Eric A, Tadaki, Douglas K, Gage, Frederick, Perdue, Philip W, Forsberg, Jonathan A, Stojadinovic, Alexander, Hawksworth, Jason S, and Brown, Trevor S

Abstract

Matrix metalloproteinases (MMPs) are crucial in the inflammatory and remodeling phases of wound healing. We previously reported the correla tion between pro-inflammatory cytokines and timing of successful combat-wound closure. We now extend our studies to investigate the correlation between wound-remodeling MMP expression and wound healing. Methods. Thirty-eight wounds in 25 patients with traumatic extremity combat wounds were prospectively studied. Surgical debridement with vacuum-assisted closure (VAC) device application was repeated every 48 to 72h until surgical wound closure. Wound effluent and patient serum were collected at each wound debridement and analyzed for five matrix metalloproteinases using the Luminex multiplex system; Millipore Corp, Billerica, MA. The primary outcome was wound healing within 30 d of definitive wound closure. Impairment was defined as delayed wound closure ( 21 d from injury) or wound dehiscence. MMP expression was com pared between impaired and normal healing wounds. Results. Elevated levels of serum MMP-2 and MMP-7 and reduced levels of effluent MMP3 were seen in im paired wounds (n = 9) compared with wounds that healed (n = 29;P 0.001). Receiver operating characteristic (ROC) curve analysis yielded area-under-the-curve (AUC) of0.744, 0.783, and 0.805, respectively. Conclusions. Impaired wound healing is characterized by pro-inflammatory MMP-2 and MMP-7. Serum and effluent concentrations of MMP-2, MMP-3, and MMP-7 can effectively predict the outcome of 1 To whom correspondence and reprint requests should be addressed at Naval Medical Research Center, Regenerative Medicine Department, 503 Robert Grant Ave, Silver Spring, MD 20910. E-mail: Trevor.Brown@med.navy.mil. traumatic war wounds and can potentially provide decision-supportive, objective evidence for the timing of wound closure., Pub. in Journal of Surgical research, v159, p633-639, 2010.

Published
2010

7. Inflammatory Biomarkers in Combat Wound Healing

Author

Hawksworth, Jason S., primary, Stojadinovic, Alexander, additional, Gage, Frederick A., additional, Tadaki, Doug K., additional, Perdue, Philip W., additional, Forsberg, Jonathan, additional, Davis, Thomas A., additional, Dunne, James R., additional, Denobile, John W., additional, Brown, Trevor S., additional, and Elster, Eric A., additional

Published
2009
Full Text
View/download PDF

8. Perioperative Blood Transfusion in Combat Casualties: A Pilot Study

Author

Dunne, James R., primary, Hawksworth, Jason S., additional, Stojadinovic, Alexander, additional, Gage, Fred, additional, Tadaki, Doug K., additional, Perdue, Philip W., additional, Forsberg, Jonathan, additional, Davis, Tom, additional, Denobile, John W., additional, Brown, Trevor S., additional, and Elster, Eric A., additional

Published
2009
Full Text
View/download PDF

12. γ-Adrenergic Blockade Accelerates Conversion of Postoperative Supraventricular Tachyarrhythmias

Author

Balser, Jeffrey R., primary, Martinez, Elizabeth A., additional, Winters, Bradford D., additional, Perdue, Philip W., additional, Clarke, Ann Wray, additional, Huang, Wenzheng, additional, Tomaselli, Gordon F., additional, Dorman, Todd, additional, Campbell, Kurt, additional, Lipsett, Pamela, additional, Breslow, Michael J., additional, and Rosenfeld, Brian A., additional

Published
1998
Full Text
View/download PDF

15. PORCINE PERITONEAL SEPSIS

Author

Kazarian, Kirk K., primary, Perdue, Philip W., additional, Lynch, William, additional, Dziki, Adam, additional, Nevola, Joseph, additional, Lee, Che-Hung, additional, Hayward, Isaac, additional, Williams, Taffy, additional, and Law, William R., additional

Published
1994
Full Text
View/download PDF

17. Transforming an Academic Military Treatment Facility Into a Trauma Center: Lessons Learned From Operation Iraqi Freedom.

Author

Elster, Eric A., Pearl, Jonathan P., DeNobile, John W., Perdue, Philip W., Stojadinovic, Alexander, Liston, William A., and Dunne, James R.

Subjects
TRAUMA centers, IRAQ War, 2003-2011, TRAUMATOLOGY, RETROSPECTIVE studies, HOSPITAL admission & discharge, REPORTING of diseases, WAR casualties
Abstract

Background: To manage the influx of patients with predominately extremity injuries from Operation Iraqi Freedom (OIF), our center was required to transform from a nontrauma academic hospital to a trauma hospital by using amultidisciplinary approach. Study Design: A retrospective chart review was performed of casualties from OIF who were received over 14 months. Results: A total of 313 casualties were received. The average number of admissions was 16 per month, except during November 2004, when there were 88 admissions over 7 days. The mean ISS for all patients was 14.1 ± 10.3. A total of 113 patients (36%) required admission to the intensive care unit for an average of 7.5 ± 5.2 days. The mean interval between injury and arrival in the continental United States was 6.5 ± 4.6 days. Most casualties suffered multisystem trauma, with extremity injuries predominating. The multidisciplinary approach to casualty care consisted of several meetings a week and included everyone involved in caring for these combat casualties. Conclusions: A multidisciplinary approach transformed an existing medical center into a trauma receiving hospital capable of managing and maintaining a surge in patient admissions resulting in minimal morbidity and mortality. This model further supports a multidisciplinary approach to trauma care and could serve as a guideline for transforming existing medical centers into trauma receiving hospitals to deal with patient overflow in the event of future civilian mass casualties. [ABSTRACT FROM AUTHOR]

Published
2009

Catalog

Books, media, physical & digital resources
See catalog results