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5. Using Functional Near-Infrared Spectroscopy to Assess Social Information Processing in Poor Urban Bangladeshi Infants and Toddlers

Author

Perdue, Katherine L., Jensen, Sarah K. G., Kumar, Swapna, Richards, John E., Kakon, Shahria Hafiz, Haque, Rashidul, Petri, William A., Lloyd-Fox, Sarah, Elwell, Clare, and Nelson, Charles A.

Abstract

Children living in low-resource settings are at risk for failing to reach their developmental potential. While the behavioral outcomes of growing up in such settings are well-known, the neural mechanisms underpinning poor outcomes have not been well elucidated, particularly in the context of low- and middle-income countries. In this study, we measure brain metabolic responses to social and nonsocial stimuli in a cohort of 6- and 36-month-old Bangladeshi children. Study participants in both cohorts lived in an urban slum and were exposed to a broad range of adversity early in life including extreme poverty, malnutrition, recurrent infections, and low maternal education. We observed brain regions that responded selectively to social stimuli in both ages indicating that these specialized brain responses are online from an early age. We additionally show that the magnitude of the socially selective response is related to maternal education, maternal stress, and the caregiving environment. Ultimately our results suggest that a variety of psychosocial hazards have a measurable relationship with the developing social brain.

Published
2019
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9. Differing Developmental Trajectories in Heart Rate Responses to Speech Stimuli in Infants at High and Low Risk for Autism Spectrum Disorder

Author

Perdue, Katherine L., Edwards, Laura A., Tager-Flusberg, Helen, and Nelson, Charles A.

Abstract

We investigated heart rate (HR) in infants at 3, 6, 9, and 12 months of age, at high (HRA) and low (LRC) familial risk for ASD, to identify potential endophenotypes of ASD risk related to attentional responses. HR was extracted from functional near-infrared spectroscopy recordings while infants listened to speech stimuli. Longitudinal analysis revealed that HRA infants and males generally had lower baseline HR than LRC infants and females. HRA infants showed decreased HR responses to early trials over development, while LRC infants showed increased responses. These findings suggest altered developmental trajectories in physiological responses to speech stimuli over the first year of life, with HRA infants showing less social orienting over time.

Published
2017
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10. Scalp-based parcellation for longitudinal fNIRS studies

Author

Magee, Abigail L., primary, Pirazzoli, Laura, additional, Sanchez-Alonso, Sara, additional, Sullivan, Eileen F., additional, Perdue, Katherine L., additional, Zinszer, Benjamin, additional, Bejjanki, Vikranth R., additional, Richards, John E., additional, Culver, Joseph P., additional, Aslin, Richard N., additional, Emberson, Lauren L., additional, and Eggebrecht, Adam T., additional

Published
2023
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11. Acute effects of subanesthetic ketamine on cerebrovascular hemodynamics in humans: A TD-fNIRS neuroimaging study

Author

Castillo, Adelaida, Dubois, Julien; https://orcid.org/0000-0002-3029-173X, Field, Ryan M; https://orcid.org/0000-0002-2254-7328, Fishburn, Frank; https://orcid.org/0000-0002-1227-2834, Gundran, Andrew, Ho, Wilson C, Jawhar, Sami, Kates-Harbeck, Julian; https://orcid.org/0000-0002-6294-909X, Aghajan, Zahra M; https://orcid.org/0000-0003-4245-3975, Miller, Naomi, Perdue, Katherine L; https://orcid.org/0000-0003-2846-3149, Phillips, Jake; https://orcid.org/0000-0002-1915-8268, Ryan, Wesley C, Shafiei, Mahdi, Scholkmann, Felix; https://orcid.org/0000-0002-1748-4852, Taylor, Moriah, Castillo, Adelaida, Dubois, Julien; https://orcid.org/0000-0002-3029-173X, Field, Ryan M; https://orcid.org/0000-0002-2254-7328, Fishburn, Frank; https://orcid.org/0000-0002-1227-2834, Gundran, Andrew, Ho, Wilson C, Jawhar, Sami, Kates-Harbeck, Julian; https://orcid.org/0000-0002-6294-909X, Aghajan, Zahra M; https://orcid.org/0000-0003-4245-3975, Miller, Naomi, Perdue, Katherine L; https://orcid.org/0000-0003-2846-3149, Phillips, Jake; https://orcid.org/0000-0002-1915-8268, Ryan, Wesley C, Shafiei, Mahdi, Scholkmann, Felix; https://orcid.org/0000-0002-1748-4852, and Taylor, Moriah

Abstract

Quantifying neural activity in natural conditions (i.e. conditions comparable to the standard clinical patient experience) during the administration of psychedelics may further our scientific understanding of the effects and mechanisms of action. This data may facilitate the discovery of novel biomarkers enabling more personalized treatments and improved patient outcomes. In this single-blind, placebo-controlled study with a non-randomized design, we use time-domain functional near-infrared spectroscopy (TD-fNIRS) to measure acute brain dynamics after intramuscular subanesthetic ketamine (0.75 mg/kg) and placebo (saline) administration in healthy participants (n= 15, 8 females, 7 males, age 32.4 ± 7.5 years) in a clinical setting. We found that the ketamine administration caused an altered state of consciousness and changes in systemic physiology (e.g. increase in pulse rate and electrodermal activity). Furthermore, ketamine led to a brain-wide reduction in the fractional amplitude of low frequency fluctuations (fALFF), and a decrease in the global brain connectivity of the prefrontal region. Lastly, we provide preliminary evidence that a combination of neural and physiological metrics may serve as predictors of subjective mystical experiences and reductions in depressive symptomatology. Overall, our studies demonstrated the successful application of fNIRS neuroimaging to study the physiological effects of the psychoactive substance ketamine and can be regarded as an important step toward larger scale clinical fNIRS studies that can quantify the impact of psychedelics on the brain in standard clinical settings.

Published
2023

13. Acute effects of subanesthetic ketamine on cerebrovascular hemodynamics in humans: A TD-fNIRS neuroimaging study

Author

Castillo, Adelaida, primary, Dubois, Julien, additional, Field, Ryan M., additional, Fishburn, Frank, additional, Gundran, Andrew, additional, Ho, Wilson C., additional, Jawhar, Sami, additional, Kates-Harbeck, Julian, additional, Aghajan, Zahra M., additional, Miller, Naomi, additional, Perdue, Katherine L., additional, Phillips, Jake, additional, Ryan, Wesley C., additional, Shafiei, Mahdi, additional, Scholkmann, Felix, additional, and Taylor, Moriah, additional

Published
2023
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16. Scalp-based parcellation for longitudinal fNIRS studies

Author

Contini, Davide, Hoshi, Yoko, O'Sullivan, Thomas D., Magee, Abigail L., Pirazzoli, Laura, Sanchez-Alonso, Sara, Sullivan, Eileen F., Perdue, Katherine L., Zinszer, Benjamin, Bejjanki, Vikranth R., Richards, John E., Culver, Joseph P., Aslin, Richard N., Emberson, Lauren L., and Eggebrecht, Adam T.

Published
2023
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17. Kernel Flow: a high channel count scalable time-domain functional near-infrared spectroscopy system

Author

Ban, Han Y., primary, Barrett, Geoffrey M., additional, Borisevich, Alex, additional, Chaturvedi, Ashutosh, additional, Dahle, Jacob L., additional, Dehghani, Hamid, additional, Dubois, Julien, additional, Field, Ryan M., additional, Gopalakrishnan, Viswanath, additional, Gundran, Andrew, additional, Henninger, Michael, additional, Ho, Wilson C., additional, Hughes, Howard D., additional, Jin, Rong, additional, Kates-Harbeck, Julian, additional, Landy, Thanh, additional, Leggiero, Michael, additional, Lerner, Gabriel, additional, Aghajan, Zahra M., additional, Moon, Michael, additional, Olvera, Isai, additional, Park, Sangyong, additional, Patel, Milin J., additional, Perdue, Katherine L., additional, Siepser, Benjamin, additional, Sorgenfrei, Sebastian, additional, Sun, Nathan, additional, Szczepanski, Victor, additional, Zhang, Mary, additional, and Zhu, Zhenye, additional

Published
2022
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19. Kernel Flow: a high channel count scalable TD-fNIRS system

Author

Ban, Han Y., primary, Barrett, Geoffry M., additional, Borisevich, Alex, additional, Chaturvedi, Ashutosh, additional, Dahle, Jacob L., additional, Dehghani, Hamid, additional, DoValle, Bruno, additional, Dubois, Julien, additional, Field, Ryan, additional, Gopalakrishnan, Viswanath, additional, Gundran, Andrew, additional, Henninger, Michael, additional, Ho, Wilson C., additional, Hughes, Howard D., additional, Jin, Rong, additional, Kates-Harbeck, Julian, additional, Landy, Thanh, additional, Lara, Antonio H., additional, Leggiero, Michael, additional, Lerner, Gabriel, additional, M. Aghajan, Zahra, additional, Moon, Michael, additional, Ojeda, Alejandro, additional, Olvera, Isai, additional, Ozturk, Meric, additional, Park, Sangyong, additional, Patel, Milin J., additional, Perdue, Katherine L., additional, Poon, Wing, additional, Sheldon, Zachary P., additional, Siepser, Benjamin, additional, Sorgenfrei, Sebastian, additional, Sun, Nathan, additional, Szczepanski, Victor, additional, Zhang, Mary, additional, and Zhu, Zhenye, additional

Published
2021
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26. Perception of Facial Emotions of Varying Intensities in 3-Year-Olds

Author

Bayet, Laurie, Perdue, Katherine L., Behrendt, Hannah F., Cataldo, Julia K, Almanza, Ruby, Richards, John E., and Nelson, Charles A.

Abstract

Bayet L., Perdue K., Behrendt H., Cataldo J. K., Almanza R., Richards J. E., & Nelson C. A. (2019) Perception of facial emotions of varying intensities in 3-year-olds. Biennial Meeting of the Society for Research in Child Development (SRCD), Baltimore, USA.

Published
2019
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29. Kernel flow: a high channel count scalable TD-fNIRS system

Author

Mohseni, Hooman, Ban, Han Y., Barrett, Geoffrey M., Borisevich, Alex, Chaturvedi, Ashutosh, Dahle, Jacob L., Dehghani, Hamid, DoValle, Bruno, Dubois, Julien, Field, Ryan M., Gopalakrishnan, Viswanath, Gundran, Andrew, Henninger, Michael, Ho, Wilson C., Hughes, Howard D., Jin, Rong, Kates-Harbeck, Julian, Landy, Thanh, Lara, Antonio H., Leggiero, Michael, Lerner, Gabriel, Aghajan, Zahra M., Moon, Michael, Ojeda, Alejandro, Olvera, Isai, Ozturk, Meric, Park, Sangyong, Patel, Milin J., Perdue, Katherine L., Poon, Wing, Sheldon, Zachary P., Siepser, Benjamin, Sorgenfrei, Sebastian, Sun, Nathan, Szczepanski, Victor, Zhang, Mary, and Zhu, Zhenye

Published
2021
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31. fNIRS in Africa & Asia: an Objective Measure of Cognitive Development for Global Health Settings

Author

Lloyd‐Fox, Sarah, primary, Moore, Sophie, additional, Darboe, Momodou, additional, Prentice, Andrew, additional, Papademetriou, Maria, additional, Blasi, Anna, additional, Kumar, Swapna, additional, Westerlund, Alissa, additional, Perdue, Katherine L, additional, Johnson, Mark H, additional, Nelson, Charles A, additional, and Elwell, Clare E, additional

Published
2016
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