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156 results on '"Percivale P"'

1. Limit of nonlinear Signorini problems for incompressible materials

Author

Mainini, Edoardo, Percivale, Danilo, and van der Putten, Robertus

Subjects
Mathematical Physics, Mathematics - Optimization and Control, 49J45, 74K30, 74K35, 74R10
Abstract

The paper is devoted to the linearization of the non linear Signorini functional in the incompressible case. The limit functional, in the sense of Gamma-convergence, may coincide with the expected one only in some particular cases.

Published
2024

2. On the weighted inertia-energy approach to forced wave equations

Author

Mainini, Edoardo and Percivale, Danilo

Subjects
Mathematics - Analysis of PDEs
Abstract

We show convergence of minimizers of weighted inertia-energy functionals to solutions of initial value problems for a class of nonlinear wave equations. The result is given for the nonhomogeneous case under a natural growth assumption on the forcing term.

Published
2023

3. Newton's second law as limit of variational problems

Author

Mainini, Edoardo and Percivale, Danilo

Subjects
Mathematics - Analysis of PDEs
Abstract

We show that the solution of the Cauchy problem for the classical ode $m \mathbf y''=\mathbf f$ can be obtained as limit of minimizers of exponentially weighted convex variational integrals. This complements the known results about weighted inertia-energy approach to Lagrangian mechanics and hyperbolic equations.

Published
2023
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4. Signorini problem as a variational limit of obstacle problems in nonlinear elasticity

Author

Francesco Maddalena, Danilo Percivale, and Franco Tomarelli

Subjects
calculus of variations, signorini problem, linear elasticity, nonlinear elasticity, finite elasticity, gamma-convergence, asymptotic analysis, unilateral constraint, Applied mathematics. Quantitative methods, T57-57.97
Abstract

An energy functional for the obstacle problem in linear elasticity is obtained as a variational limit of nonlinear elastic energy functionals describing a material body subject to pure traction load under a unilateral constraint representing the rigid obstacle. There exist loads pushing the body against the obstacle, but unfit for the geometry of the whole system body-obstacle, so that the corresponding variational limit turns out to be different from the classical Signorini problem in linear elasticity. However, if the force field acting on the body fulfils an appropriate geometric admissibility condition, we can show coincidence of minima. The analysis developed here provides a rigorous variational justification of the Signorini problem in linear elasticity, together with an accurate analysis of the unilateral constraint.

Published
2024
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6. Asymptotic behavior of constrained local minimizers in finite elasticity

Author

Mainini, Edoardo, Ognibene, Roberto, and Percivale, Danilo

Subjects
Mathematics - Analysis of PDEs, Mathematical Physics, Mathematics - Optimization and Control
Abstract

We provide an approximation result for the pure traction problem of linearized elasticity in terms of local minimizers of finite elasticity, under the constraint of vanishing average curl for admissible deformation maps. When suitable rotations are included in the constraint, the limit is shown to be the linear elastic equilibrium associated to rotated loads.

Published
2021

7. Elastic-brittle reinforcement of flexural structures

Author

Maddalena, Francesco, Percivale, Danilo, and Tomarelli, Franco

Subjects
Mathematics - Optimization and Control, Mathematical Physics, Mathematics - Analysis of PDEs
Abstract

This note provides a variational description of the mechanical effects of flexural stiffening of a 2D plate glued to an elastic-brittle or an elastic-plastic reinforcement. The reinforcement is assumed to be linear elastic outside possible free plastic yield lines or free crack. Explicit Euler equations and a compliance identity are shown for the reinforcement of a 1D beam., Comment: 30 pages

Published
2021

8. Sharp conditions for the linearization of finite elasticity

Author

Mainini, Edoardo and Percivale, Danilo

Subjects
Mathematics - Analysis of PDEs, Mathematical Physics, Mathematics - Optimization and Control
Abstract

We consider the topic of linearization of finite elasticity for pure traction problems. We characterize the variational limit for the approximating sequence of rescaled nonlinear elastic energies. We show that the limiting minimal value can be strictly lower than the minimal value of the standard linear elastic energy if a strict compatibility condition for external loads does not hold. The results are provided for both the compressible and the incompressible case.

Published
2020

9. Variational linearization of pure traction problems in incompressible elasticity

Author

Mainini, Edoardo and Percivale, Danilo

Subjects
Mathematics - Analysis of PDEs, Mathematical Physics, Mathematics - Optimization and Control
Abstract

We consider pure traction problems and we show that incompressible linearized elasticity can be obtained as variational limit of incompressible finite elasticity under suitable conditions on external loads.

Published
2020

10. Linearization of elasticity models for incompressible materials

Author

Mainini, Edoardo and Percivale, Danilo

Subjects
Mathematics - Analysis of PDEs, Mathematical Physics, Mathematics - Optimization and Control
Abstract

We obtain linear elasticity as $\Gamma$-limit of finite elasticity under incompressibility assumption and Dirichlet boundary conditions. The result is shown for a large class of energy densities for rubber-like materials.

Published
2020

12. Euler's optimal profile problem

Author

Maddalena, Francesco, Mainini, Edoardo, and Percivale, Danilo

Subjects
Mathematics - Optimization and Control, 49Q10, 49K30
Abstract

We study an old variational problem formulated by Euler as Proposition 53 of his `Scientia Navalis' by means of the direct method of the calculus of variations. Precisely, through relaxation arguments, we prove the existence of minimizers. We fully investigate the analytical structure of the minimizers in dependence of the geometric parameters and we identify the ranges of uniqueness and non-uniqueness.

Published
2019

15. A new variational approach to linearization of traction problems in elasticity

Author

Maddalena, Francesco, Percivale, Danilo, and Tomarelli, Franco

Subjects
Mathematics - Optimization and Control, Mathematics - Analysis of PDEs, 49J45, 74K30, 74K35, 74R10
Abstract

A new energy functional for pure traction problems in elasticity has been deduced in [23] as the variational limit of nonlinear elastic energy functional for a material body subject to an equilibrated force field: a sort of Gamma limit with respect to the weak convergence of strains when a suitable small parameter tends to zero. This functional exhibits a gap that makes it different from the classical linear elasticity functional. Nevertheless a suitable compatibility condition on the force field ensures coincidence of related minima and minimizers. Here we show some relevant properties of the new functional and prove stronger convergence of minimizing sequences for suitable choices of nonlinear elastic energies., Comment: arXiv admin note: text overlap with arXiv:1810.01339

Published
2018
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16. The gap in Pure Traction Problems between Linear Elasticity and Variational Limit of Finite Elasticity

Author

Maddalena, Francesco, Percivale, Danilo, and Tomarelli, Franco

Subjects
Mathematics - Analysis of PDEs, Mathematics - Optimization and Control
Abstract

A limit elastic energy for pure traction problem is derived from re-scaled nonlinear energy of an hyperelastic material body subject to an equilibrated force field. We show that the strains of minimizing sequences associated to re-scaled non linear energies weakly converge, up to subsequences, to the strains of minimizers of a limit energy, provided an additional compatibility condition is fulfilled by the force field. The limit energy is different from classical energy of linear elasticity; nevertheless the compatibility condition entails the coincidence of related minima and minimizers. A strong violation of this condition provides a limit energy which is unbounded from below, while a mild violation may produce a limit energy with infinitely many extra minimizers which are not minimizers of standard linear elastic energy and whose strains are not uniformly bounded. A relevant consequence of this analysis is that a rigorous validation of linear elasticity fails for compressive force fields that do not fulfil such compatibility condition.

Published
2018
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17. The minimal resistance problem in a class of non convex bodies

Author

Mainini, Edoardo, Monteverde, Manuel, Oudet, Edouard, and Percivale, Danilo

Subjects
Mathematics - Optimization and Control
Abstract

We characterize the solution to the Newton minimal resistance problem in a class of radial q-concave profiles. We also give the corresponding result for one-dimensional profiles. Moreover, we provide a numerical optimization algorithm for the general nonradial case.

Published
2017

18. Variational Problems for Foppl-von Karman plates

Author

Maddalena, Francesco, Percivale, Danilo, and Tomarelli, Franco

Subjects
Mathematics - Optimization and Control, Mathematical Physics
Abstract

Some variational problems for a Foppl-von Karman plate subject to general equilibrated loads are studied. The existence of global minimizers is proved under the assumption that the out-of-plane displacement fulfils homogeneous Dirichlet condition on the whole boundary while the in-plane displacement fulfils nonhomogeneous Neumann condition. If the Dirichlet condition is prescribed only on a subset of the boundary, then the energy may be unbounded from below over the set of admissible configurations, as shown by several explicit conterexamples: in these cases the analysis of critical points is addressed through an asymptotic development of the energy functional in a neighborhood of the flat configuration. By a $\Gamma$-convergence approach we show that critical points of the Foppl-von Karman energy can be strongly approximated by uniform Palais-Smale sequences of suitable functionals: this property leads to identify relevant features for critical points of approximating functionals, e.g. buckled configurations of the plate. Eventually we perform further analysis as the plate thickness tends to 0, by assuming that the plate is prestressed and the energy functional depends only on the transverse displacement around the given prestressed state: by this approach, first we identify suitable exponents of plate thickness for load scaling, then we show explicit asymptotic oscillating minimizers as a mechanism to relax compressive states in an annular plate., Comment: 32 pages

Published
2017
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20. Percutaneous microwave ablation of disappearing colorectal liver metastases using US-MR fusion imaging guidance with integration of pre-chemotherapy imaging: A case report

Author

Arianna Nivolli, Emanuele Barabino, Francesca Lacelli, Matteo Arnò, Diego Ivald, Giulia Pittaluga, Andrea Percivale, and Paolo Gazzo

Subjects
Colorectal cancer, Disappearing liver metastases, Microwave ablation, Fusion imaging, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Liver metastases that disappear after chemotherapy are called vanishing or disappearing liver metastases. These metastases represent a diagnostic and clinical challenge as their biological behaviour is hardly predictable and their treatment is not completely standardized. In this case report, we present an interesting solution to treat disappearing liver metastases using percutaneous microwave ablation and US/MRI fusion guidance employing pre-chemotherapy MRI as reference imaging.

Published
2022
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21. 18 months computed tomography follow-up after Covid-19 interstitial pneumonia

Author

Michela Barini, Ilaria Percivale, Pietro Danna, Vittorio Longo, Pietro Costantini, Andrea Paladini, Chiara Airoldi, Mattia Bellan, Luca Saba, and Alessandro Carriero

Subjects
Covid-19, coronavirus, CT, lung, pneumonia, Public aspects of medicine, RA1-1270
Abstract

Background: Our aim is to evaluate the possible persistence of lung parenchyma alterations, in patients who have recovered from Covid-19. Design and methods: We enrolled a cohort of 115 patients affected by Covid-19, who performed a chest CT scan in the Emergency Department and a chest CT 18 months after hospital discharge. We performed a comparison between chest CT scan 18 months after discharge and spirometric data of patients enrolled. We obtained quantitative scores related to well-aerated parenchyma, interstitial lung disease and parenchymal consolidation. A radiologist recorded the characteristics indicated by the Fleischner Society and “fibrotic like” changes, expressed through a CT severity score ranging from 0 (no involvement) to 25 (maximum involvement). Results: 115 patients (78 men, 37 women; mean age 60.15 years old ±12.52). On quantitative analysis, after 18 months, the volume of normal ventilated parenchyma was significantly increased (16.34 points on average ±14.54, p

Published
2022
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23. Mechanics of Reversible Unzipping

Author

Maddalena, F., Percivale, D., Puglisi, G., and Truskinovsky, L.

Subjects
Quantitative Biology - Other Quantitative Biology, Quantitative Biology - Biomolecules
Abstract

We study the mechanics of a reversible decohesion (unzipping) of an elastic layer subjected to quasi-static end-point loading. At the micro level the system is simulated by an elastic chain of particles interacting with a rigid foundation through breakable springs. Such system can be viewed as prototypical for the description of a wide range of phenomena from peeling of polymeric tapes, to rolling of cells, working of gecko's fibrillar structures and denaturation of DNA. We construct a rigorous continuum limit of the discrete model which captures both stable and metastable configurations and present a detailed parametric study of the interplay between elastic and cohesive interactions. We show that the model reproduces the experimentally observed abrupt transition from an incremental evolution of the adhesion front to a sudden complete decohesion of a macroscopic segment of the adhesion layer. As the microscopic parameters vary the macroscopic response changes from quasi-ductile to quasi-brittle, with corresponding decrease in the size of the adhesion hysteresis. At the micro-scale this corresponds to a transition from a `localized' to a `diffuse' structure of the decohesion front (domain wall). We obtain an explicit expression for the critical debonding threshold in the limit when the internal length scales are much smaller than the size of the system. The achieved parametric control of the microscopic mechanism can be used in the design of new biological inspired adhesion devices and machines.

Published
2009
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25. Outcomes after surgery for children in Africa (ASOS-Paeds): a 14-day prospective observational cohort study

Author

Torborg, Alexandra, Meyer, Heidi, El Fiky, Mahmoud, Fawzy, Maher, Elhadi, Muhammed, Ademuyiwa, Adesoji O, Osinaike, Babatunde Babasola, Hewitt-Smith, Adam, Nabukenya, Mary T, Bisegerwa, Ronald, Bouaoud, Souad, Abdoun, Meriem, El Adib, Ahmed Rhassane, Kifle Belachew, Fitsum, Gebre, Meseret, Taye, Desalegn Bekele, Kechiche, Nahla, Fadalla, Tarig, Abdallah, Bareeq, Chaibou, Maman Sani, Nyarko, Mame Yaa Adobea, Ki, Kélan Bertille, Shalongo, Sarah, Mulwafu, Wakisa, Thomson, Emma, Traore, Mamadou Mour, Ndonga, Andrew, Bittaye, Mustapha, Samateh, Ahmadou Lamin, Munlemvo, Dolly M., Kalongo, Jean Jacques, Coulibaly, Yacaria, Coulibaly, Youssouf, Ravelojaona, Vaonandianina, ANDRIAMANARIVO, Lalatiana, RAHERISON, Arsitide Romain, RANDRIAMIZAO, Harifetra Mamy Richard, RAMKALAWAN, Kushal, Omar, Mohamed Abdinor, Ndikontar, Raymond, Joseph, Donamou, Dahir, Shukri, Mohamed, Mubarak, Ali Daoud, Hassan, Ndarukwa, Pisirai, OTIOBANDA, Gilbert Fabrice, Banguti, Paulin, Neil, Kara, Derbew, Miliard, Fanny, Marvin, Smalle, Isaac, Taylor, Elliott H, Duvenage, Hanel, Hardy, Anneli, Kluyts, Hyla, Pearse, Rupert, Biccard, Bruce, AARON, Olurotimi Idowu, Abd Elazeem Mohammed, Hossam Aldein Samir, Abdalkarim, Batool, Abdalla, Abubaker, Abdallah, Mohamed Abubaker Ahmed, Abdeewi, Saedah, Abdel Ghafar, Taqwa, Abdelaleem, Ali, Abdelaleem, Ibrahim Abdelmonaem, Abdelgader, Khansaa, Abdelgadir, Waffa, Abdelhafez, Mohammed, Abdelhalim, Ahmed, Abdelkabir, Mohammed, Abdelkader Osman, Mohamed, Abdelkarim, Maha, Abdelkarim, Mohamed, Abdelmohsen, Sarah Magdy, Abdelnassir, Mazin, Abdelrahman, Ahmed Saber Mohamed, Abdelwahed, Aya Elsayed, Abdelzaher, Mohamed, Abderrahim, Baba Ahmed, Abdoulaye, Touré, Abdulai, Samira, Abdulghaffar, Yunus A., Abdullah, Fatimaalzahraa, Abdullahi, Lawal Barau, Abdullahi, Muzammil, Abdulrazik, Sarah, Abdulsalam, Khalifa Ibrahim, Abdulwahed, Eman, Abdus-Salam, Rukiyat, ABE, TOLUSHE, Abera Mulugeta, Gersam, Aboelghait, Aml Ali, Abol Oyoun, Nariman, Aboubekr, Boumediene, Abraham, Meera, Abu, Mohammed, Abuagila, Ahlam ali, Abubakar, Maimuna, Abugilah, Mohammed, Abuzeid, Issa A, Achouri, Djelloul, Acquah, Serwah Akua, Adam, Nusiba Bushra Ahmed, ADAMU, AUWAL, Adamu, Kabir Musa, ADAMU, MUHAMMAD, ADAMU, Sani, Adane, Samuel Gashu, Adeaga, Mojolaoluwa, Adebayo, Sikiru, Adedire, Adejare, Adegoke, Paul Aderemi, Ademuyiwa, Adesoji O, Adeniyi, Adebayo Augustine, Adeoye, Ibukunoluwa, Aderibigbe, Gbenga, ADEROUNMU, Azeezat, ADEYEMI, WILLIAMS, ADEYEMO, Adekunle, Adigun, Tinuola, Adika, Enoch Delad, ADISA, Adewale O, Adjei, Esther, Adjepong-Tandoh, Ernest Kwame, Ads, Alaa Mohamed, ADUMAH, Dr Collins Chijioke, ADUMAH, Lilian ogechi, Adzamli, Innocent, Afari, Jonas, Afedo, Wisdom, Affan, Abubaker, AFOLAYAN, Ayodeji Olawale, Agaba, Stuart, Agbeno, Evans, Agbonrofo, Peter, Aghadi, Ifeanyi, AGU, EDITH, Agyen, Thomas, Agyen-Mensah, Kwasi, Ahensan, Daasebre, Ahmad, Misbahu Haruna, AHMED, Awrayit, Ahmed, Linda, Ahmed, Nidal Youseef Altaher Aboh, Ahmed, Rubaa, Ahmed Jroush, Mohamed, ahmed maghur, Hasan, AHOGNI, G.N. Geofroid, Ait Yahia, Smain, Aji, Narjiss, Aji, Sani Ali, Akerele, William, Akhideno, Irene, Akinmokun, Israel, AKINNIYI, Akin Taofeek, Akinniyi, Ayodeji, AKINYEMI, Samuel, Akitoye, Olumide Adeleke, AKPAETTE, Iniofon Clement, Akuma, Terungwa Jacob, Akuokor, Daniel, Akwei, Clement Nii-Akwei, Al Bashir, Rayan Badran Hamed, Al Gharyani, Mohamed Fathi, al Islam ben Jouira, Rayet, Aladelusi, Timothy, Alakaloko, Felix, Alameen, Hind, Alameen Moheyaldeen, Mohammed, Alaogaly, Mona, Alarabi, Rehab, Alawami, Milud, Alazabi, Basma Masaud, Alazabi, Mona, Albakosh, Bashir Abobaker, ALBDULRRAZIQ, HUSAYN MOHAMMED ElFEETOURI, Aldieb, Asmma, Aldressi, Wafa, Alegbeleye, Godwin E., Alfa, Yakubu, Alhadad, Qamrah, Alhaddad, Arwa R, Alhaddad, Hayfa Faraj, Alhadi, Aliya, Alhamali, Aya, Alharam, Abtisam, Alhlafi, Majduldeen, Alhouwasi, Basmah, Alhudhairy, Sara, Ali, Abdallah Motasim Ahmed, Ali, Ahmed Jama, Ali, Almuaz, Ali, Asma, Ali, Enas, Ali, Mutwakil, Ali, Salem, Ali, Yunusa Y., Ali Ahmed, Abdelbaset, Aliozor, Sampson, Aljamal, Sarah, Alkaseek, Akram, Alkhalifa, Elmustafa, Alkoni, Samah, Allie, Abbaas, Almelyan, Khawla, Almugaddami, Ayman, Almujreesi, Asmaa, Alqady, Eithar, Alragheai, Alaa Ahmed, Alshareea, Entisar, Alshareef, Abulnasir, Alsori, Mohamed, Altomy, Seham Ahmed, Al-Touny, Aiman, Al-Touny, Shimaa A., Alum Aguma, Rachel, Alwaer, Nuha Miftah, Al-zletni, Hadeel, Alzwai, Marwa, Amaambo, Nelago, Amah, Christopher C, Amary, Marwa, Amengle, Ludovic Albert, Amesho, Shiwana Lineekela Omwene, Ametepe, Mawuli, Amkhatirah, Emad, Amnaina, Mohamed Gamal, Amoah, Benjamin, Amoah, Joseph Kofi, Amo-Aidoo, Nana Adjoa Simitsewa, Amoako-Boateng, Mabel, Ampong, Jude, Anane-Fenin, Betty, Anarfi, Samuel, Andriamanarivo, Mamy Lalatiana, Aniakwo, Luke, Aniteye, Ernest, Ankrah, Levi Nii-Ayi, Anno, Audrey, Anyanwu, Lofty-John Chukwuemeka, Anyigba, Edem, Appeadu-Mensah, William, Appiah-Thompson, Peter, Apraku-Peprah, Ewuarabena Lydia, Aremu, Shuaib Kayode, Arinaitwe, Moses, Armah, Ralph, Arthur, Augustine, Arthur, Douglas, Asah-Opoku, Kwaku, Asante, Mabel, Asante-Asamani, Alvin, Asare, Angbo, Asasira, Lausa, Ashfersh, Mohamed, ASHINDOITIANG, John A., Ashong, Joycelyn, Ashraf Salah, Mohamed, Asiedu, Charles, Asiedu, Isaac, Asiyanbi, Kolawole, Asla, Amir, Asman, Wilfred, Asoegwu, Emeka J., Assalhi, Mohamed, Assim, Claudia, Asudo, Felicia Dele, Atai, Alice Gertrude, Ateeqa, Sara Bin, Atim, Terkaa, Atindama, Solomon, ATIQUI, IJLAL, Atrih, Zoubir, Attah, Raphael Avidime, Awad, Ahmed K, Awedew, Atalel Fentahun, Awedew, Atalel Fentahun, Aween, Husayn, Awere-Kyere, Lawrence, Awindaogo, Joseph, Awori Achani, Margaret, Ayad, Kusay, Azab, Ahmed, Azas, Alberta, Aziza, Bochra, Azize, Diallo Abdoul, AZOUI, Abdelkrim, Azouz, Jomana, Baba, Suleiman, Babalola, Olakunle Fatai, Babiker, Mona, Baddoo, Daniel, Badi, Aml, BADMUS, Sarat Abolore, Badr, Helmy, Bah, Abdoulie, Bah, Fatoumata Yakhie, Bah, Kajali, Bah, Marma Tumaneh, Bahroun, Sumayyah, Baidoo, Ebikela, Baidoo, Kenneth, Baidoo, Richard, Bakare, Adewumi, Bakeer, Hiba Baliad, Baky Fahmy, Mohamed A, Balogun, James, Bamigboye, Babatunde, Bankah, Patrick, Banson, Mabel, Barhouma, Yehia Emad, Barongo, Mugisha, BASHIR RABIU, MOHAMMED, Bassem, Adham, Bedair, Mohamed Adel Ali, Beeharry, Hemanshu Rambojan, Beeharry, Shanjugsing, Bekele, Sintayehu, Belie, Orimisan, Belkhair, Abdulmunem, Ben Ahmed, Yosra, Ben Ashur, Abir, Ben Hamida, Bahaeddin, Benade, Christia, BENMANSEUR, Sawsen, Bensebti, Amina Amel, BERDAI, Mohamed Adnane, Beyuo, Vera, Biala, Marwa, Bilson-Amoah, Estella, Bin wali, Salema Subhi, Binnawara, Muhannud, Birlie Chekol, Wubie, Birqeeq, Ghada, Biyase, Thuli, Blankson, Paa Kwesi, Boakye, Benedict, Boakye, Benedict, Boakye-Acheampong, Kwame, Boakye-Yiadom, Kwaku, Boateng, Joseph, Bobaker, Salem, Bode, Christopher, Bogoslovskiy, Alexander, Bolarinwa, Eniola Sefiu, Boretti, Lorenzo, Botchway, Maame Tekyiwa, Botha, Christo, BOUDA, B. David, BOURENANE, Haithem, BOUZBID, Sabiha, Boye, Jeffrey, Branny, Mthelebofu, Brown, George Darko, Brown, Warren, Bua, Emmanuel, BWALA, KEFAS JOHN, Camara, Bakary, Camara, M'mah Lamine, Carol, Tisana, Ceesay, Winston, Chafee, Karim, Chaklie Agegnehu, Bewuketu, Chamir, Congo, Chaziya, Peter YC, Chellan, Chantal, Cheniki, Narimane, Chennouf, Sarra, Chepkoech, Eglah, Chilango, Creamy, Chinda, John Yola, Chokwe, Thomas M., Choutri, Hichem, Christian, Nana Ama, Chukwu, Isaac, Chummun, Girish, Cilliers, Celeste, Cloete, Estie, Collison, Carol, Cronje, Larissa, Daary, Dennis, DAD, Bouzid, Daddy, Hadjara, Dahilo, Enoch Auta, Dairam, Jenitha, Dalaf, Manar Salim, Damson, Pempho, Daneji, Sulaiman Muhammad, Daniel, Adekunle, Daoud, Asmaa, Daoud, Hassan, Darat, Tarik Darat, Darko, Kwadwo Opoku, Darko, Kwame, Davidson, Kerryn, Davies, Abigail, Dawang, Yusuf Davou, Dayal, Kishan, Dayie, Makafui, de Goede, Adele, de Goede, Adele, Deelawar, Bibi Waardanaaz, Derwish, Khawla, Desalu, Ibironke, Dessalegn Beza, Andinet, Dhege, Celestino, Dhilraj, Deepika, Diallo, Thierno Sadou, Diaw, Mbaye, Diaw Diop, Amadou, DIENE, Mansour, Dieng, Mactar, Dippenaar, Tinus, Djagbletey, Robert, Djedid, Nihel Klouche, Djouonang, Kamga Telly, Dominique, Shep, Drammeh, Basiru, Drissi, Hajer, du Bruyn, Aritha, Dube, Thandeka, Dufe, Rebecca, Dung, Dido, Earl, Ettiene, Ebrahem, Osama Khalifa Ali, Ebrahim, Zahier, Edena, Morrison E., Effa Ngono, Rosa, Egbuchulem, Kelvin, Egdeer, Amin, Eguma, Stella A., Ehimhantie, Martins, EJIOFOR, Ogochukwu Chidi, Ejuma, Lucy O., Ekenze, Sebastian, Ekhmaj, Reyad Almokhtar, Ekor, Oluwayemisi, EKPA, Sifonobong, Ekpemo, Chidi Samuel, Ekudo, Joseph, Ekwunife, Okechukwu Hyginus, El Koraichi, Alae, El Magrahi, Hamida, El Mejrab, Mohsen, El Sadek, Rania, El YOUBI, Haitam, Eladani, Oman, Elamesh, Sara Abdel Hamid, Elamien, Mohanad, Elamin Elnour, Moheyaldien Ahmed, Elbadawy, Merihan A, Elbaseet, Hesham, Elderwy, Ahmad A., Elebute, Olumide, Elgamal, Mostafa, Elgenidy, Anas, Elghareeb, Ahmed, Elgherwi, Laila, Elhadad, Rasha, Elhadi, Ahmed, Elhassan, Mohamed, Elkhouly, Abdallah Mohamed, Ellebedy, Mohamed, ELMAJRI, MOHAMED FUAD, Elmandouh, Omar, Elmandouh, Reem, Elmorsi, Rami, ELOMBILA, Marie, Elsadek, Menan, Elsalhawy, Shady, Elsayem, Karam, Elshafiey, Mahmoud, El-Sharkawi, Mohammad, Elshazly, Mohamed, Eltaub, Darine, Eltayeb, Almoutaz A, Eltayeb, Mohammed Eltayeb Zainelabdean, Eltegani Abdalla, Abeer, ElWakeel, Mai, Embu, Henry, Emoru, Arthur, Enicker, Basil, Enti, Donald, Entsua-Mensah, Kow, Eseile, Samuel Ideyonbe, Essuman, Vera Adobea, Et-taghy, Hiba, Etwire, Victor, Eyaman, Kuba Daniel, Ezbeida, Mabroukah, EZEKIEL, ANTHONY SABO, Ezidiegwu, Stanley Ugochukwu, Ezomike, Uchechukwu Obiora, FABOYA, Omolara, Fadlalmola, Hammad.A., FAGBAYIMU, Oluwatobiloba Micheal, Faida, Hamza, FALL, Khady, Farahat, Sherif, Faraj, Ali, Faraj, Noora, Farghaly, Amal, Farhat, Karima Omar Ahmed, Farinyaro, Aliyu Umar, Fathi Bani, Ghada, Fattah, Ahmed, Fawzy, Maher, Fening, Nana, Fentahun Emrie, Assefa, Fidieley, Melody, Fikadu Keneni, Dame, Fischer, Monique, Flint, Margot, Fodo, Naledi, Fofana, Naby, Fokeerah, Nitish, Folami, Emmanuel, Folokwe, Siyasanga, Fonternel, Doors, Fosi Kamga, Gacelle, Fotso, Luc Kamga, Fourtounas, Maria, Frankish, Leanne, Gabier, Ilhaam, Gacii, Vernon M., Gaffoor, M Sheik, Gagara, Moussa, GALADIMA, Hajara Aminu, Gamubaka, Richard, Ganey, Mike, Ganiyu, Oseni Oyediran, Gasa, Nompumelelo, Gatheru, Antony P., Gawu, Victoria Sena, Gaya, Subha Shita Devi, GAYE, Ibrahima, Gebremichael Ganta, Ashagre, Gelaw, Kassahun Girma, Geldenhuys, Lieze, Getachew Tegegn, Ayenachew, Ghemmied, Malak, Ghmagh, Reem, GILES, AHEREZA, Ginsburg, Ricky Ginsburg, Girma, Kassahun, Gjam, Fatima, Glover-Addy, Hope, Gobin, Veekash, Gomeh, Patricia, Gomez, Dimingo, Gorelyk, Alexandro, Gossaye, Abay, Govender, Veneshree, Grant, Jenny, Grayson, Britney L., Grobbelaar, Mariette, Gueye, Khadim Rassoul, GUIRO, Habibou, Gumede, Simphiwe, Gurure, Desire, Gusibat, Anwar, Gyeke-Boafo, Nana Kwame, HACHEMI, Sihem, Haddis, Kullehe, Haidar, Arwa, Haif, Assia, Hameed-Ikram, Sarwat, Hamid, Haytham, Hamukwaya, Dilona, Hanson, Nana Andoh, Hanzi, Joseph, Hardcastle, Timothy, Harissou, Adamou, Hasan, Ameerah, Hasan, Hayat Ben, Hasan, Najat Ben, Hashi, Abdullahi Said, Hashish, Amel A, Hassaan, Ibrahim, Hassan, Sadiq, Hassan, Sakariye Abdullaahi, Hassan, Tasneem, Hassan, Zeinab, Hassane, Maman Lawal, Hassanein, Mohamed, Hawu, Yoli, Haywood, David, Heelan, Halima, Hendricks, Natalie, Hillah, Ayayi, Hlela, Qinisile, HMAMOUCHI, Badreddine, Hoko, Zanele, Honny, Dorothy, Honore, Samba, Houidi, Senda, Human, Thys, Hussain, Eiman, Hussain Kona, Moataz Hashim, Hussein, Yara, Ibekwe, Titus Sunday, Ibiyemi, Akeem, IBIYEYE, TAIBAT, Ibrahim, Ibrahim Ali, Ibrahim, Lawal Ibrahim, Ibrahim, Soaleh, Ibrahim Abubakar, Amina, Ibrahim Alain, Traore, Idipo, Frieda, Idoko, Godwin, Idowu, Olusola, Idris, Mohammad El-Amin, Igaga, Elizabeth Namugaya, Iindongo, Etuuva, IITULA, Petrus, IKOTUN, Oluwafunmilayo, ILLE, Gloria, Imposo, Desire Hubert, Invernizzi, Jonathan, Irungu, Eric, Isbayqah, Areej Mohammed, Isbayqah, Eenas Mohammed, Ismael, Guibla, Ismail, Ali M, Itambi, Asoh Maxwell, Jabang, John Nute, Jaga, Rudhir, Jaganath, Ushir, Jaiteh, Lamin, Jallow, Cherno S, James, Olutayo, Javed, Sayed, Jithoo, Sandhya, Jlidi, Said, Joel, Lessan, Johnson, Marianne, JONES, TAIWO, Jooma, Zainub, Joomye, Shehzaad, Joosab, Mehboob, JOUINI, Riadh, Jubail, Mohamed J, Juggoo, Chaya, Jumbi, Timothy Mwai, Kaabar, Nejib, Kabirou, Mourtala, Kabiru, Abdulkadir Muhammad, Kabre, B. Yvette, Kache, Stephen, Kacimi, Salah Eddine Oussama, KADAS, ABUBAKAR SAIDU, KAHANSIM, Barminas, Kalipa, Mandisa, Kalongo, Jean Jacques Kabuley, Kalu, Nmesomachi Enyidiya, Kamate, Benoi, Kamwangen, Gracia Mitonga, Kandjimi, Matti, Kanjana-Zondo, Nokuzola, Kankpeyeng, Lawrence, Kapalamula, Tiyamike, Karadji, Souleymane, Kargbo, Mohamed Alieu, Karghul, Mohamed, Kaskar, Razeena, Kasker, Razeena, Kasobya, Faith, Kassem, Ossama, Kateregga, George, Kayima, Peter, Kedwany, Ahmed M., Ken-Amoah, Sebastian, Kenneth, Tomanya Kakura, KERISSE, Amina Nour El-Houd, KERKENI, Yosra, Khairi, Rania, Khaled, Mohamed, Khalifa, Eissa, Khalifa, Marwa Suliman, Khalil, Mohamed Kamal, Khattab, Mohamed S I, Khodary, Ahmed Refaat, Khumalo, Bridget Florence, Khumalo, Phindile, Kigayi, Jean Pierre, Kimutai, Timothy Kiprotich, KINDO, Bassirou, KIRFI, ABDULLAHI MUSA, Koggoh, Patience, Koko, Alshaima A, Kopieniak, Marcin, Kotagiri, Chandra, Kotey, Emily, Kouicem, Aya Tinhinane, Kpangkpari, Richard, Kudoh, Vincent, Kufonya, Norman, Kuhn, Warren, Kutor, Jasper, Kwakye, Akosua, Kynes, J. Matthew, Lambrechts, Lelanie, Lamiri, Rachida, LANRE, OLOKO NASIRUDEEN, Larvie, Prince, Lateef, Azeez Kehinde, LATRECHE, Samir, Lawal, Taiwo, Leballo, Gontse, Lebereki, Simon, Lee, Dorinda, Leeb, Gregory, Leonard, Tristan, LEYONO-MAWANDZA, Peggy Dalliah Gallou, Likongo, Ted Botawaosenge, Limalia, Ziyaad, LIMAN, HARUNA USMAN, Loae, Nada, Lompoli, Beinvenue Nkoy Ena, Lusungu, Dodo, M.Mokhtar, Fatma AL-Zahraa, Madany, Mohie El-Din Mostafa, Maddy, Reginald Jeff, Madombwe, Gladmore, Mafabi, Solomon, Magashi, Mahmoud Kawu, Maharaj, Sanvir, Mahfouz, Shaimaa Mahmoud, Mahlare, Korowe Rose Voncil, Mahmoud, Fathia, Maikassoua, Mamane, Maison, Patrick, Maiwald, Dela, Makhoba, Philisiwe, Makinita, Sewela Grace, Makou epse Tolefac, Myriam, Malau, Thomas Kefas, Mamathuntsha, Tshilidzi Godfrey, Mamo, Tihitena Negussie, Mamuda, Atiku, Mandundzo, Paidamoyo, Mangray, Hansie, Mani, Salma, Manneh, Ebrima K, Mansour, Noureldin Mohamed, Manyere, DV, Mapurisa, Amarylis, Mare, Pieter, Martin, Mogammad Ebrahim, Mashaal, Abdelhafeez, Mashaya, Sonela, Masilela, Patience Busisiwe, Mathebula, Ruth, Mathinya, Tlhapane, Matlala, Tumelo Kwena, Matlou, Mabitsela, Matos-Puig, Roel, Matoug, Salmin, Maudarbocus, Mohammad Jeelani, Mavesere, Haziel Pindukai, Mavila, Jackson, Mayet, Shafeeqa, Maygag, Mohamed, Mbatha, Nonhlanhla, Mbatudde, Rita, Mbiya Kapinga, Anne, Mbuyamba, Jojo, Mbuyi, Ali T, Mdlalose, Nkosinathi, Prowling, Megan, Mejeni, Nathalie, Mekonnen Ejigu, Yayehyirad, Merghani, Safa, Metogo, Junette Epse Njoki, Mhiri, Riadh, Mhone, Lyness, Michael, Afieharo, Miko, Abdullahi Mustapha, Milad, Ahmed, Mishra, Ravi, Mjadu, Londiwe, Mkhontwana, Nokonwaba, Mlambo, Nompilo, Mncwango, Zama, Mngoma, Gcina, Mnguni, Mzamo, Modekwe, Victor Ifeanyichukwu, Mogane, Palesa, Moghazy, Rama, Mogotsi, Kena, Mohalal, Mohamed Salah, Mohamed, Amin Awad Alamin, Mohamed, Maria, Mohamed, Molhema Eltaib Elamin, Mohamed, Suleyman Abdullahi, Mohamedkheir, Mohamed Abdelmoneim, Mohammad, Ahmad Lofty, Mohammad, Alhassan Datti, Mohammad, Aminu Mohammad, Mohammed, Abdulrahman, Mohammed, Muhanned, Mohammed, Rabiu Isah, Mohammed, Rehab, Mohammed, Taha Salah Abdelmaksaod, Mohammedosman, Doaa, Mohsen, Siham Moftah, Molla Getahun, Amsalu, Moloisi, Makwati, Monib, Fatma A, Moodley, Kirushin, Moopanar, Manogran, Morgan, Fatma, Moris, Baluku, Morna, Martin, Moses, Vaughn, Mostafa, Mahmoud Mohamed, Motiang, Mammie, Motseoile, Toni, Motshabi, Palesa, MOUSSAOUI, Nassima, Mpoto, Dany Bolimo, MPOY EMY MONKESSA, Christ Mayick, MRARA, BUSISIWE, Mshelbwala, Philip Mari, Msherghi, Ahmed, Msibi, Trevor, Mubunda, Raphael Kapend, Muhammad, Abubakar Bala, Muhammad, Saminu, Muhanguzi, Joshua, Muhindo, Ruth, Mukenga, Martin Mamba, Mukuna, Patrick Miteo, Mulewa, Deogracias, Munanzvi, Kudzayi Sarah, Mungur, Luckshmanraj, Munubi, Aziz, Munyalo, Francisca Syovata, Muriithi, Julius M., Musa, Abdullahi Aliyu, Musa, Kareem, Musa, Mosaab Abdelhafiz Ebrahim, Musana, Fred, Musewu, Tongo Douglas, Musiitwa, Albino Kiboonwa, Mwangi, Caroline M., Mwepu, Idesbald Mwebe, Mwepu, Michel Ilunga, Mwika, Peter Mwirichia, Mwiti, Timothy M., Myeni, Physician, Mzoneli, Nosisi, Naana, Reyam, Nabukenya, Gladys, Nabunya, Susan, Naidoo, Alishka, Naidoo, Verushka, Naidu, Priyanka, Nakyanzi, Caroline, Nambi, Esther, Nampawu, Mary Juliet, Nampiina, Gorret, Namutebi, Hasifah, Nana, Benedict, Nanda, Joëlle Sandra Youssa, Nanimambi, Juliana, Nantongo, Betty, Napolitano, Luisa, Naser, Alg, Nassar, Ahmad Sammy, Nassar, Muhammad Sammy, Nasser, Nadine, Nawezo, Jacob Gerald, NDIAYE, Alain, NDIAYE, Cheikh Ahmed Tidiane, Ndiaye, Françoise, Ndibarekera, Sarah Harriet, Ndjoko, Sylvie Mishondo, Ndlovu, Msizi, Nduwayezu, Richard, Negash, Samuel, Nehema, Sarah, Neil, Kara, Neizer, Margaret, NEJMI, Sifeddine, Nezam-Parast, Masoud, Ng How Tseung, Kenny, Ngcelwane, Thandokazi, Ngene, Ikenna, Nghidinwa, Hilka, Ngissah, Reuben, Ngock, George Farrar Fola Ngock, Ngouane, Diane, Ngumi, Zipporah, Nibret, Yonas, NIENGO OUTSOUTA, Gilles, Njie, Masirending, NJOKANMA, Rapheal Azuka, Nkhata, Lister, Nkhuna, Nyajane Thomas, Nkosi, Nobuhle, Nkosi, Sebenzile, Nkwembe, Christophe Mualuka, Nnaji, Chimaobi, Nneji-Akazie, Tochukwu, Nongqo, Nezisa, Nortey, Michael, Noutakdie Tochie, Joel, Nsaful, Josephine, Nsimire, Berthe Barhayiga, Nte, Stanley K., Ntshingila, Cebile, Ntsie, Nthabiseng Precious, Ntsoane, David, Ntumy, Michael Yao, Nuer-Allornuvor, Gloria, Nuhu, Samuel, Nutsuklo, Prudence, Nwachukwu, Callistus Uchenna, NWAFULUME, NNAEMEKA, Nwangwu, Emmanuel, Nwankwo, Elochukwu P, Nyame, Clement Agyekum, Nyamekye, Evelyn, Nyankah, Eunice, Nyoka-Mokgalong, Cecilia, Oase, Divine, Obande, Joseph Orinya, Obbeng, Ambe, Obeng-Adjei, Grace-Imelda, Obianyo, Ijeoma, Obianyo, Nene E, Obiechina, Sylvester, OBRI, Abraham I., ODI, TEMITOPE, Odingo, Jonathan, Oelofsen, Siobhan, Ofori, Emmanuel, Ofori-Adjei, Dziffa, Ogaji, Idoko Monday, Ogundoyin, Olakayode Olaolu, OGUNLEYE, OLABISI, OGUNS, Abayomi, Ogunsua, Oluseyi, Ohemeng-Mensah, Elvis, Ojediran, Olubukola, Ojediran, Oluwabukade, Ojewuyi, Abiodun, Ojewuyi, Olufemi, Ojo, Adedoyin, OJO, Olugbenga Olalekan, Ojo, Omotayo, Okedare, Amos, Okenwa, Samuel C., Oko, Adariku Godwin, Okojie, Nkechi, Okonkwo, Leonard Nduka, Okoth, Peter, Okunlola, Abiodun Idowu, Okunlola, Cecilia Kehinde, Okurut, Mathew, Oladimeji, Motunrayo, Oladiran, Ajibola, Olagunju, Ganiyat R., Olajide, Abdul-Rahman Lukman, Olajide, Adewale. Timothy, Olang, Patrick R., Olayinka, Oluwakemi, Olori, Samson, Olulana, Dare, Olulana, Dare Isaac, Olusanya, Bolutife, Omar, Duaa Eisa, Omar, Mohamed Abdinor, Onakpoya, Uvie, ONeil, Matthew, Onen, Hudson, ONYEKA, Chinonso, Oosthuizen, Alexis, Opandoh, Isabella, Opiyo, Sophy, Oppong, Jonathan, Orewole, Tesleem Olayinka, Orji, Mathias, Osagie, Olabisi, Osagie, Osasumwen T., Osaheni, Osayomwanbo, Osama Sleem, Adham, Osawa, Francis Omondi, Osei, Fred, Osei-Nketiah, Samuel, Osei-Poku, Dorcas, Osman, Alaa, Osman Ahmed, Mohammed, Osman Suliman, Sarah Omer, Otchere, Kofi, Othman, Amani Alsayd Abdulsalam, Othman, Eman, Othman, May, Otim, Paul, Otim, Tonny, Otman, Rema Hassan, Otoki, Violet, OUDJHIH, Messa, OUEDRAOGO, Issaka, OUEDRAOGO, P. Justin, Ousmane Hamady, Issa, Ouyahia, Amel, OWOJUYIGBE, Afolabi, Owoo, Christian, Owoo, Precious, Owusu Boamah, Matthew, Oyedele, Abisola, Oyedepo, Olanrewaju, Oyegbola, Christianah, Panday, Juniata, Parker, Ewomazino U. Evi, Parker, Ilyas, Parker, Robert K., Pembe, Julie Ndjondo, Percivale, Beatrice, Pereko, Janet, Pérez, Mariela, Perumal, Neville, Pillay, Leresse, Pretorius, Robyn, Prinsloo, Roz, Pryce, Charles, Puryag, Ashveen, QUADRI, Oladeji Raheem, Quansah, Kofi, Quarcoopome, Cornelia, Quarshie, Amanda, Quartson, Elizabeth, Quashie-Sam, James, Rabiu, Ayuba, Rabiu, Taofeek, Rahma, Manal, Rahman, Ganiyu Adebisi, Rais, Mounira, Rajah, Chantal, Rakotondrainibe, Aurélia, Ramakrishnan, Rema, Ramatou, Sabo, Ramdawon, Brinda, Ramdhani, Kirthi, Ramkaun, Yeswant, RAPHAEL, OSELE, Raslan, Hani Mohammed Ahmed, Redelinghuys, Cara, Riffi, Omar, Rikhotso, Hundzukani, Roberts, Charles AP, Robertson, Caroline, Roland, Nchufor, Roos, John, S. Abdalgadir, Esra, Saad, Alshaimaa, Saad, Mahmoud M., Saad El-Tanekhy, Aalaa, Saadi, Cyrine, Saadu, Tasiu, Saber, Mohamed, Sabir Yassin, Fatima Mohammed, Sabo, Vinishe Yakubu, Sabra, Tarek Abdelazem, Saeid, Dawoud Amhimmid, Safar, Amna, Sagboze, Sandra, Sahnoun, Lassaad, Salahu, Babangida Mohammed, Salami, Kelvin, Salawu, Adedayo Idris, Saleh, Hawazen, Saleh, Ismail Ali, Saleh, Khetam Mohamed, Salele, Aliyu Mohammed, Salem, Fatima, Salem, Osama, Salih, Mohammed Ali Ismael Alamin, Salisu, Ibrahim, Sall, Mouhamedoun, SAMB, Cheikh Fall, Sangak, Isam A, Sanoussi, Nanzir Moctar, Sanya, Douglas, Sanyang, Anaumana B, Sarpong, Pokua, SARR, Joseph Niame, Schnaubelt, Romy, Searyoh, Kafui, SECK, Ndèye Fatou, Secka, Abdoulie Sering, Seif, Mohamed, Seilbea, Yvonne, Semret Hailu, Berhe, Sepenu, Perez, Sewlall, Janice, Seyi-Olajide, Justina, Shai, Shiluva, Shalaby, Abdullah Mohamad Omar, SHAPHAT, IBRAHIM, Shava, Garai, Sheidu Owuda, Abdullahi, Sheshe, Abdurrahman Abba, Shetiwy, Mosab, Shezi, Nomusa, Shihab, Maryam Husam, Shitakumuna, Helena, Shitaye, Nebiyu, Shitta, Andrew H., Sholadoye, Tunde Talib, Shouasha, Princely, Shu'aibu, Naziru Garba, Shuiap, Nouran musbah, Sibeko, Bongekile, Sikhakhane, Sebe, Sikwete, Guigui, Sime Gizaw, Habtamu, Simelane, Nhlanhlenhle, Simon, Edwina, Singh, Usha, SIRAJALDIN, Abdulla, Siriboe, Esme, Siyothula, Thozama, Siyotula, Thozama, Smart-Yeboah, Awo, SMITH, Saidat, Solala, Sivuyisiwe, Soliman, Eman A., Solo, Corinne Eulalie, Sombéwendin Charles, Ilboudo, Sonaike, Monisola, Songden, David Zumnan, Sottie, Daniel, Soualili, Zineddine, Soula, Enas, Souleymane, Sidibe, SOWANDE, Oludayo Adedapo, Spytko, Alex, Srir, Daria Omar M, Ssebuguzi, Lawrence, Stegmann, George Frederik, Strauss, Lindsey, Struwig, Estee, Succi, Marcello, Suleiman, Abdul-Rasheed, Suliman, Mazin, Swartz, Mikhail, Taha, Taha M., Takai, Idris Usman, Takou, Bougoue Horline, Takrouney, Mohammed Hamada, Takure, Augustine, TALABI, Ademola Olusegun, Tall, Mamadou, Taute, Carla, Tawfik, Mohamed, Taylor, Jenna, Tembe, Dias Salomao, Temesgen, Fissha, Tesfaye, Emnet, Theko, Dineo, Thiart, Mari, Thompson, Ruary, Thuer, Linda, Tientcheu Fabrice, Tim, Tilahun, Zekaryas Belete, Tilahun Woldetsadik, Tsion, Timo, Manuella, Timotews, Namene, Tjiyokola, David, Tolani, Musliu Adetola, TOUABTI, Souhem, Traoré, Diakaridia, Tsegha, Livingfaith Jighjigh, Tseli, Mbeki, Tumuhimbise, Christine, Tumukunde, Janat, Tunkara, Salihu F S, Turshan, Laila, Turton, Edwin, Uchendu, Chukwudi Chukwuemeka, UDIE, Gabriel U., UDOSEN, Joseph E., Ugalahi, Mary, Ugwu, Euphemia M., UGWU, Ikechukwu Ethelbert, Ugwu, Jideofor Okechukwu, Ugwunne, Chuka A, Ukpabio, Ukpabio E.I., Umar, Aminu Muhammed, UMEH, Chizoba Linda, Ungen, Rowena, Usang, Usang, Usenbo, T, Usman, Mustapha Ibrahim, UWAYESU, Roda, Van Aswegen, Benjamin, van der Byl, Ashley, van der Linde, Pieter, van der Walt, Stephan, van Schalkwyk, Hendrik Petrus, van Tonder, Charme, van Vuuren, Suleen, van Wyk, Janri, van Zyl, Sudene, Wabule, Agnes, Wacays, Abdirahman, Waheed Mowafy, Ghada, Waisiko, Bethleen, Walawah, David, Walithandia, Eziron, Wamwaki, John, Wataaka, Nicholas, Wessels, Nelia, Wessels, Nelia, Williams, Emmanuel, WILLIAMS, Omolara, Woldegiorgis, Abel, Wolfaardt, George, Wondossen, Mekete, Woodun, Ritish, Workineh, Saleamlak Tigabie, Wubetu, Solomon, Yahia, Mohamed, Yakubu, Hamisu, Yakubu, Saidu Yusuf, Yalewu, Dawit Zerihun, YAMEOGO, T. Azer-Clovis, Yeboah, Francis, YENYI AHUKA LONGOMBE, Thérèse, Younes, Eman, Young, Chad, Younis, Nageia, Younus, Tarig Yousuf Ibrahim, YUSUF, STEPHEN, Zaki, Fatima, Zbida, Ibrahim, Zenda, Thubelihle, ZERIZER, Yassine, Zingoni, Kudzai, Zitouni, Hayett, ZONGO, P. Valentin, Zubi, Abdalrahem, Zulu, Nonhlanhla, Zulu, Nqobile, Yakubu, Hamisu, Yakubu, Saidu Yusuf, Yalewu, Dawit Zerihun, YAMEOGO, T. Azer-Clovis, Yeboah, Francis, YENYI AHUKA LONGOMBE, Thérèse, Younes, Eman, Young, Chad, Younis, Nageia, Younus, Tarig Yousuf Ibrahim, YUSUF, STEPHEN, Zaki, Fatima, Zbida, Ibrahim, Zenda, Thubelihle, ZERIZER, Yassine, Zingoni, Kudzai, Zitouni, Hayett, ZONGO, P. Valentin, Zubi, Abdalrahem, Zulu, Nonhlanhla, and Zulu, Nqobile

Abstract

Safe anaesthesia and surgery are a public health imperative. There are few data describing outcomes for children undergoing anaesthesia and surgery in Africa. We aimed to get robust epidemiological data to describe patient care and outcomes for children undergoing anaesthesia and surgery in hospitals in Africa.

Published
2024
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26. Fatality rate and predictors of mortality in an Italian cohort of hospitalized COVID-19 patients

Author

Bellan, Mattia, Patti, Giuseppe, Hayden, Eyal, Azzolina, Danila, Pirisi, Mario, Acquaviva, Antonio, Aimaretti, Gianluca, Aluffi Valletti, Paolo, Angilletta, Roberto, Arioli, Roberto, Avanzi, Gian Carlo, Avino, Gianluca, Balbo, Piero Emilio, Baldon, Giulia, Baorda, Francesca, Barbero, Emanuela, Baricich, Alessio, Barini, Michela, Barone-Adesi, Francesco, Battistini, Sofia, Beltrame, Michela, Bertoli, Matteo, Bertolin, Stephanie, Bertolotti, Marinella, Betti, Marta, Bobbio, Flavio, Boffano, Paolo, Boglione, Lucio, Borrè, Silvio, Brucoli, Matteo, Calzaducca, Elisa, Cammarata, Edoardo, Cantaluppi, Vincenzo, Cantello, Roberto, Capponi, Andrea, Carriero, Alessandro, Casciaro, Francesco Giuseppe, Castello, Luigi Mario, Ceruti, Federico, Chichino, Guido, Chirico, Emilio, Cisari, Carlo, Cittone, Micol Giulia, Colombo, Crizia, Comi, Cristoforo, Croce, Eleonora, Daffara, Tommaso, Danna, Pietro, Della Corte, Francesco, De Vecchi, Simona, Dianzani, Umberto, Di Benedetto, Davide, Esposto, Elia, Faggiano, Fabrizio, Falaschi, Zeno, Ferrante, Daniela, Ferrero, Alice, Gagliardi, Ileana, Gaidano, Gianluca, Galbiati, Alessandra, Gallo, Silvia, Garavelli, Pietro Luigi, Gardino, Clara Ada, Garzaro, Massimiliano, Gastaldello, Maria Luisa, Gavelli, Francesco, Gennari, Alessandra, Giacomini, Greta Maria, Giacone, Irene, Giai Via, Valentina, Giolitti, Francesca, Gironi, Laura Cristina, Gramaglia, Carla, Grisafi, Leonardo, Inserra, Ilaria, Invernizzi, Marco, Krengli, Marco, Labella, Emanuela, Landi, Irene Cecilia, Landi, Raffaella, Leone, Ilaria, Lio, Veronica, Lorenzini, Luca, Maconi, Antonio, Malerba, Mario, Manfredi, Giulia Francesca, Martelli, Maria, Marzari, Letizia, Marzullo, Paolo, Mennuni, Marco, Montabone, Claudia, Morosini, Umberto, Mussa, Marco, Nerici, Ilaria, Nuzzo, Alessandro, Olivieri, Carlo, Padelli, Samuel Alberto, Panella, Massimiliano, Parisini, Andrea, Paschè, Alessio, Pau, Alberto, Pedrinelli, Anita Rebecca, Percivale, Ilaria, Re, Roberta, Rigamonti, Cristina, Rizzi, Eleonora, Rognoni, Andrea, Roveta, Annalisa, Salamina, Luigia, Santagostino, Matteo, Saraceno, Massimo, Savoia, Paola, Sciarra, Marco, Schimmenti, Andrea, Scotti, Lorenza, Spinoni, Enrico, Smirne, Carlo, Tarantino, Vanessa, Tillio, Paolo Amedeo, Vaschetto, Rosanna, Vassia, Veronica, Zagaria, Domenico, Zavattaro, Elisa, Zeppegno, Patrizia, Zottarelli, Francesca, and Sainaghi, Pier Paolo

Published
2020
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28. Diagnostic Accuracy of the Magnetic Resonance Imaging in Adult Post-Ganglionic Brachial Plexus Traumatic Injuries: A Systematic Review and Meta-Analysis

Author

Massimiliano Leigheb, Stefano Tricca, Ilaria Percivale, Davide Licandro, Andrea Paladini, Michela Barini, Giuseppe Guzzardi, Federico A. Grassi, Alessandro Stecco, and Alessandro Carriero

Subjects
brachial plexus, MRI scan, MRI diffusion weighted, nervous system traumas, peripheral nerves, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Background: Traumatic brachial plexus injuries are rare but serious consequences of major traumas. Pre-ganglionic lesions are considered irreparable, while post-ganglionic injuries can be potentially treated if an early diagnosis is available. Pre-surgical diagnosis is important to distinguish low-grade from high-grade lesions and to identify their location. The aim of the review is to evaluate the diagnostic accuracy of magnetic resonance imaging (MRI) in the identification of adult post-ganglionic lesions due to traumatic brachial plexus injuries, compared to intraoperative findings. Methods: Research on the main scientific electronic databases was conducted. Studies of adults with traumatic post-ganglionic brachial plexus injuries were included. The index test was preoperative MRI and the reference standard was surgical exploration. Pooled sensitivity and specificity were calculated. Results: Four studies were included for the systematic review, of which three articles met the inclusion criteria for the meta-analysis. Pooled sensitivity and pooled specificity values resulted high. The sensitivity value is associated with a high heterogeneity index of the selected literature. Conclusion: MRI can be considered, despite the limits, the gold standard exam in morphological evaluation of brachial plexus injuries, particularly in the diagnosis of post-ganglionic traumatic injuries.

Published
2021
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29. Primary hyperparathyroidism: epidemiology, clinical features, diagnostic tools and current management

Author

Andrea Percivale, Paola Gnerre, Giulio Damonte, Sandra Buscaglia, Mario Monachesi, Lionello Parodi, Rodolfo Tassara, Gianluca Curletti, and Giovanni Saccomani

Subjects
Primary hyperparathyroidism, parathyroidectomy, hypercalcemic status., Medicine
Abstract

Primary hyperparathyroidism (PHPT) is a clinical condition characterized by overactive parathyroid gland secretion of parathyroid hormone with concurrent alteration of the phosphocalcemic metabolism. We present a literature review on primary hyperparathyroidism addressing key on clinical presentation, causes, medical and surgical treatment at the best of our knowledge. Based on this review we confirm the role of serum calcium and serum level examination, as well as we define the definitive treatment for PHPT being parathyroidectomy. In case of contraindication for surgery, medical treatment can play a relevant role.

Published
2015
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30. 'BEHAVIOURAL STUDY OF PRIMATES IN A ZOO SETTING IN MONTEVIDEO (URUGUAY)'.

Author

Ana Lucia Ilardia Elhordoy and Andrea Carlos Percivale

Subjects
Science, Biology (General), QH301-705.5
Abstract

En una búsqueda permanente de innovación educativa, surge el presente proyecto de trabajo interinstitucional, que contó con apoyo de la Facultad de Ciencias (UDELAR). El objetivo principal del mismo es que los estudiantes conozcan y se familiaricen con una investigación científica de comportamiento animal y de esa forma intentar responder a la pregunta: “Todos somos primates, pero ¿qué tan primates somos?” El proyecto se basa en el estudio del comportamiento en cautiverio de dos especies de primates, Papio hamadryas y Lemur catta, en el Zoológico “Villa Dolores”, Montevideo, Uruguay. Se realizó una valoración de aspectos positivos y negativos (tipo de recinto, ambientación y cuidados, estructura de grupo), habilitando una nueva dimensión de análisis: el “Enriquecimiento ambiental”. A partir de la construcción conjunta de un Etograma (entre estudiantes de los diferentes Centros Educativos de Secundaria) se realizó un análisis de los comportamientos más frecuentes registrados, en una comparación con el comportamiento humano. La Evaluación, considerada un aspecto fundamental, ha sido continua y coordinada durante el proceso. El trabajo deja abierto el debate sobre los objetivos y los roles que deberían cumplir los Parques Zoológicos, las Reservas. ¿Podríamos hablar de “Centros de Recuperación de Fauna”? ¿Quiénes deberían participar en la toma de decisiones al respecto?

Published
2015

35. Surgical treatment of liver and kidney metastasis from an adenoid cystic carcinoma of the submandibular gland: case report

Author

Ferrari, Cecilia, Franceschi, Angelo, Percivale, Andrea, and Griseri, Guido

Abstract

Introduction: Adenoid cystic carcinomas (ACCs) account for 10% of all malignant salivary tumours. They are slow-growing but locally aggressive. Reports of liver and renal metastases are rare.Case description: A 58-year-old woman who had undergone resection of a left submandibular ACC in 1995 was referred to our centre for follow-up in 2018. A computed tomography scan revealed two lesions: one on segment six of the liver and the other on a kidney. A hepatic wedge resection and right nephrectomy were performed. The postoperative course was uneventful. At 2-year follow-up, the patient was alive and well with no evidence of disease.Conclusion: Management of ACC is a therapeutic challenge because of its tendency for distant metastases. The literature recommends regular follow-up imaging and radical surgical treatment but specific guidelines for the approach to recurrence are lacking.

Published
2021
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37. The impact of COVID-19 lockdown on infectious diseases epidemiology: The experience of a tertiary Italian Pediatric Emergency Department.

Author

Rotulo, Gioacchino Andrea, Percivale, Beatrice, Molteni, Marta, Naim, Alessandro, Brisca, Giacomo, Piccotti, Emanuela, and Castagnola, Elio

Abstract

Introduction: The aim of this study was to describe the rate and types of community-acquired respiratory infections observed in a pediatric ED during the SARS-CoV-2 related lockdown in Italy and to compare data with the same period of previous year.Methods: A retrospective analysis of medical charts of patients arrived at the ED of Gaslini Children's Hospital from 10th March 2020 to 30th April 2019 and the same frame of 2020 were performed. We compared two groups by demographics, duration of fever before ED admission, triage code, number of patients hospitalized after ED evaluation. We calculated proportion and incidence rate for airborne infections, fever, and urinary tract infections (UTI), appendicitis, and gastroenteritis for control.Results: 1362 children arrived at the ED during the lockdown compared to 5628 in the same period of 2019 (-75,8%). No difference was noticed (27.7% vs 28.4%) in the total amount of infectious episodes. A significant reduction in rate of incidence and proportion were observed for upper respiratory tract infections (21,4% vs 28%), otitis (2,6% vs 16,2%), streptococcal infections (0,5% vs 5,2%) and bronchiolitis (2,1% vs 5,7%). Conversely, FUO (27,8 vs 11,1%), infectious mononucleosis (2,6% vs 0,4%), UTI (7,4% vs 2,9%) and appendicitis (6,8% vs 1,1%) significantly increased. Median time from the onset of fever and arrival in ED was significantly lower in 2020 group.Conclusion: Our results demonstrated a reduction in community-acquired respiratory infections during the lockdown for COVID-19. The increase in rate of FUO and febrile conditions, together with the short time from fever onset and ED visit could be related to the fear for a SARS-CoV-2 infection. [ABSTRACT FROM AUTHOR]

Published
2021
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38. The Pan - COVID - AGICT Study. The impact of COVID-19 pandemic on surgically treated pancreatic cancer patients. A multicentric Italian study.

Author

Dorma, Maria Pia Federica, Giuliani, Giuseppe, Guerra, Francesco, Santelli, Francesco, Esposito, Alessandro, De Pastena, Matteo, Turri, Giulia, Pedrazzani, Corrado, Kauffmann, Emanuele Federico, Boggi, Ugo, Solaini, Leonardo, Ercolani, Giorgio, Mastrangelo, Laura, Jovine, Elio, Di Franco, Gregorio, Morelli, Luca, Mazzola, Michele, Ferrari, Giovanni, Langella, Serena, Ferrero, Alessandro, La Mendola, Roberta, Abu Hilal, Mohamnad, Depalma, Norma, D’Ugo, Stefano, Spampinato, Marcello Giuseppe, Frisini, Marco, Brolese, Alberto, Palaia, Raffaele, Belli, Andrea, Cillara, Nicola, Deserra, Antonello, Cannavera, Alessandro, Sagnotta, Andrea, Mancini, Stefano, Pinotti, Enrico, Montuori, Mauro, Coppola, Alessandro, Di Benedetto, Fabrizio, Coratti, Andrea, Giuliani, Giuseppe, Guerra, Francesco, Santelli, Francesco, Esposito, Alessandro, De Pastena, Matteo, Cova, Chiara, Bianchi, Beatrice, Nobile, Sara, Maruccio, Martina, Faustini, Federico, Turri, Giulia, Pedrazzani, Corrado, Kauffmann, Emanuele Federico, Boggi, Ugo, Solaini, Leonardo, Ercolani, Giorgio, Mastrangelo, Laura, Jovine, Elio, Di Franco, Gregorio, Morelli, Luca, Mazzola, Michele, Ferrari, Giovanni, Langella, Serena, Ferrero, Alessandro, La Mendola, Roberta, Hilal, Mohamnad Abu, Depalma, Norma, D’Ugo, Stefano, Spampinato, Marcello Giuseppe, Frisini, Marco, Brolese, Alberto, Palaia, Raffaele, Belli, Andrea, Cillara, Nicola, Deserra, Antonello, Cannavera, Alessandro, Sagnotta, Andrea, Mancini, Stefano, Pinotti, Enrico, Montuori, Mauro, Pecora, Irene, Messinese, Simona, Salvischiani, Lucia, Esposito, Sofia, Ferraro, Luca, Rega, Daniela, Delrio, Paolo, La Raja, Carlotta, Spinelli, Antonino, Massaron, Simonetta, De Nardi, Paola, Deidda, Simona, Restivo, Angelo, Marano, Alessandra, Borghi, Felice, Piccoli, Micaela, Cozzani, Federico, Del Rio, Paolo, Marcellinaro, Rosa, Carlini, Massimo, De Rosa, Raffaele, Scabini, Stefano, Maiello, Fabio, Polastri, Roberto, Zese, Monica, Parini, Dario, Casaril, Andrea, Moretto, Gianluigi, De Leo, Antonio, Catarci, Marco, Trapani, Renza, Zonta, Sandro, Marsanic, Patrizia, Muratore, Andrea, Coppola, Alessandro, Caputo, Damiano, Andreuccetti, Jacopo, Pignata, Giusto, Mariani, Lorenzo, Ceccarelli, Graziano, Giuseppe, Rocco, Bolzon, Stefano, Grasso, Mariateresa, Testa, Silvio, Germani, Paola, de Manzini, Nicolò, Coletta, Diego, De Franco, Lorenzo, Benigni, Roberto, Tribuzi, Angela, Marra, Ubaldo, Di Marino, Michele, Zorcolo, Luigi, Lisi, Giorgio, Allisiardi, Fabrizio, Grieco, Michele, Righetti, Carolina, Grassia, Michele, Lucchi, Andrea, Bagaglini, Giulia, Sica, Giuseppe S., Manara, Michele, Turati, Luca, Macone, Lorenzo, Carminati, Roberta, Mariani, Pierpaolo, Rizzo, Gianluca, Coco, Claudio, Pennella, Francesca Pennetti, Rondelli, Fabio, Romano, Lucia, Giuliani, Antonio, Albino, Vittorio, Leongito, Maddalena, David, Giulia, Misitano, Pasquale, Pasulo, Silvia, Baiocchi, Gian Luca, Baldari, Ludovica, Cassinotti, Elisa, Boni, Luigi, Capolupo, Gabriella Teresa, Caricato, Marco, Bombardini, Cristina, Anania, Gabriele, Dibra, Rigers, Martines, Gennaro, Oliva, Renato, Carati, Maria Vittoria, Grazi, Gian Luca, Marchegiani, Francesco, Spolverato, Gaya, Celotto, Francesco, Pucciarelli, Salvatore, La Torre, Filippo, Iannone, Immacolata, Krizzuk, Dimitri, Sammartino, Francesco, Catalano, Giorgia, Strignano, Paolo, Romagnoli, Renato, Piccione, Domenico, Nardo, Bruno, Reddavid, Rossella, Degiuli, Maurizio, Gerosa, Martino, Maggioni, Dario, Zuolo, Michele, Rigamonti, Marco, Ghazouani, Omar, Galleano, Raffaele, Percivale, Andrea, Tirloni, Luca, Moraldi, Luca, Fabbri, Nicolò, Feo, Carlo Vittorio, Colombo, Samuele, Merlini, Ilenia, Di Saverio, Salomone, Barbato, Giuseppe, Coratti, Francesco, Formisano, Giampaolo, Bianchi, Paolo Pietro, Bengala, Carmelo, and Coratti, Andrea

Abstract

In this article we aimed to perform a subgroup analysis using data from the COVID-AGICT study, to investigate the perioperative outcomes of patients undergoing surgery for pancreatic cancers (PC) during the COVID-19 pandemic.

Published
2024
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39. Interim Results of Intra-Arterial 4’-Epi-Doxorubicin for Liver Metastases

Author

Simoni, G., Nobile, M. T., Repetto, M., Percivale, P. L., Razzi, S., Tatarek, R., Vidili, M. G., Muggianu, M., Civalleri, D., Herfarth, Ch., editor, Senn, H. J., editor, Baum, M., editor, Diehl, V., editor, von Essen, C., editor, Grundmann, E., editor, Hitzig, W., editor, Rajewsky, M. F., editor, Schlag, Peter, editor, Hohenberger, Peter, editor, and Metzger, Urs, editor

Published
1988
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45. Role of B72.3 iodine 125-labeled monoclonal antibody in colorectal cancer detection by radioimmunoguided surgery

Author

Di Carlo, V, Badellino, F, Stella, M, De Nardi, P, FAZIO, FERRUCCIO, Percivale, P, Bertoglio, S, Schenone, F, Benevento, A, Carcano, G., Di Carlo, V, Badellino, F, Stella, M, De Nardi, P, Fazio, F, Percivale, P, Bertoglio, S, Schenone, F, Benevento, A, and Carcano, G

Subjects
Adult, Male, Antibodies, Monoclonal, Predictive Value of Test, Colorectal Neoplasm, Equipment Design, Middle Aged, Sensitivity and Specificity, Iodine Radioisotope, Iodine Radioisotopes, Diagnostic Techniques, Surgical, Radioimmunodetection, Evaluation Studies as Topic, Predictive Value of Tests, Humans, Female, Neoplasm Recurrence, Local, Colorectal Neoplasms, Human, Aged, Neoplasm Staging
Abstract

Background. Radioimmunoguided surgery (RIGS) by means of radiolabeled monoclonal antibodies and a probe has been reported to be useful in recognizing subclinical tumor deposits during operation. Aim of this study was to understand the limits of this technique and to access the potential diagnostic use of RIGS in colorectal cancer surgery. Methods. Monoclonal antibody B72.3 reacting with TAG 72 antigen, labeled with iodine, 125, was injected in 32 patients with primary tumors and in 22 patients with recurrent colorectal cancer. One hundred thirty-three suspected tumor sites were evaluated during operation by means of probe and resected with immunohistochemistry as control. Results. Primary tumor sites were localized by RIGS in 60% of cases, and recurrent sites were localized in 82% of cases. There was a significant correlation both for primary (p

Published
1994

46. Prognostic value of sentinel lymph node biopsy in the pathologic staging of colorectal cancer patients

Author

Bertoglio, S, Sandrucci, Sergio, Percivale, P, Goss, M, Gipponi, M, Moresco, L, Mussa, Baudolino, and Mussa, Antonio

Subjects
Male, Rectal Neoplasms, Sentinel Lymph Node Biopsy, Biopsy, Middle Aged, Colorectal cancer, Sigmoid Neoplasms, Predictive Value of Tests, Lymphatic Metastasis, Feasibility Studies, Humans, Female, Neoplasm Metastasis, Sentinel lymph node, Lymph Nodes, Prospective Studies, Coloring Agents, Hematoxylin, Aged, Neoplasm Staging
Abstract

Over the last decade, lymphatic mapping and sentinel lymph node (sN) biopsy have greatly increased the possibility of identifying nodal metastasis in clinically node-negative patients with melanoma and breast cancer, thus improving the accuracy of pathologic staging. Recently, sN biopsy has been applied also in colorectal cancer. This prospective study aimed to assess its feasibility and accuracy in predicting regional lymph nodes metastases in colorectal cancer patients as well as the impact on treatment decision-making.Lymphatic mapping was accomplished by means of blue dye, which was intraoperatively injected into the subserosa overlying the tumor site in 26 patients undergoing colorectal cancer surgery. Following bowel resection, the operative specimen was inspected to identify each blue-stained node, the sN, which was sent separately to the pathologist. One half of each sN was examined by multiple 200 microm sections, while the second half was examined by standard bi-valving technique with hematoxylin-eosin (H and E) staining; all the other regional non-sentinel nodes were routinely examined by standard bi-valving technique and H and E staining.At least one sN was detected in 24 of 26 patients (92.3%); two patients with rectal cancer had no sN identified. Overall, 70 sN were retrieved into the operative specimens, with a mean of 2.9 sNs/patient, and 19 sNs were tumor-positive. An agreement between sN and regional lymph-node status was observed in 20 of 24 patients (83.4%). The sN was histologically negative in two of nine patients with positive regional nodes (sensitivity = 77.8%; false-negative rate of 22.2%); in two of seven patients with tumor-positive sN (28.6%), the sN was the exclusive site of regional nodal metastasis. The negative predictive value was 88.2% (15 of 17 patients), and the overall accuracy was 91.7% (22 of 24 patients). As regards the contribution to the detection of nodal metastasis according to the pathologic technique, standard H and E bi-valving technique detected 16 of 19 tumor-positive sNs (84.2%) while, by means of serial sectioning, metastases were detected in the remaining 3 of 19 sNs (15.8%).The sN biopsy proved feasible, with a rather short learning curve. The focused analysis of the sN by means of serial sectioning improved the detection rate of nodal metastasis compared to standard bi-valving examination, so that a more accurate nodal staging should be expected; finally, an elective localization of metastasis within the sN was observed in almost one third of regional node-positive patients.

Published
2004

49. Adjuvant post-operative radiotherapy vs radiotherapy plus 5-FU and levamisole in patients with TNM stage II-III resectable rectal cancer. A phase III randomized clinical trial. P.A.R. Cooperative Study Group

Author

Cafiero, Ferdinando, Gipponi, M., Somma, C. D., Scarpati, D., Sertoli, M. R., Peressini, A., Percivale, P., and Badellino, F.

Subjects
Adult, Male, Radiotherapy, Rectal Neoplasms, Middle Aged, drug therapy/pathology/radiotherapy/surgery, Treatment Outcome, Levamisole, therapeutic use, Antineoplastic Combined Chemotherapy Protocols, Chemotherapy, Humans, Female, Adult, Aged, Antineoplastic Combined Chemotherapy Protocols, therapeutic use, Chemotherapy, Adjuvant, Female, Fluorouracil, administration /&/ dosage, Humans, Levamisole, administration /&/ dosage, Male, Middle Aged, Neoplasm Staging, Radiotherapy, Adjuvant, Rectal Neoplasms, drug therapy/pathology/radiotherapy/surgery, Treatment Outcome, Fluorouracil, administration /&/ dosage, Adjuvant, Aged, Neoplasm Staging
Published
1995

50. Two-stage Hepatectomy in Two Regional District Community Hospitals: Perioperative Safety and Long-Term Survival

Author

Griseri, Guido, Ceriotti, Michela, Percivale, Andrea, Franceschi, Angelo, Santori, Gregorio, Benasso, Marco, and Pellicci, Riccardo

Abstract

Introduction Surgical resection offers the best chance of cure for patients with colorectal liver metastases (CRLMs). Two-stage hepatectomy (TSH) has been demonstrated to be safe and effective to obtain curative resection in patients with multiple, bilobar CRLMs that are unresectable in a single procedure. Up to now TSH has been the prerogative of dedicated liver surgery centers. The aim of this study was to assess the safety and effectiveness of TSH also in community hospitals.Methods Of 294 patients operated on for CRLMs between September 1997 and June 2012 in 2 district community hospitals (belonging to the same regional healthcare district), 43 (14.6%) were scheduled for TSH. Thirty-eight/43 received neoadjuvant and/or bridge chemotherapy (2 neoadjuvant only, 4 neoadjuvant and bridge, 32 bridge only).Results The mean follow-up was 35.74 ± 29.53 months. Five-year overall survival (OS) was 31.4%, with a median survival time of 31 months. Twenty-nine patients completed the planned procedure (OS: 42.9%; median 47 months), while 14 did not because of disease progression (OS: 0%; median 13 months). No operative mortality occurred within the first 90 days either after the first or second stage.Conclusions Our results suggest good efficacy and safety of TSH even when performed in a community hospital setting. Shifting patient selection from neoadjuvant to bridge chemotherapy had no impact on outcome once the clearing of the liver had been achieved. In patients presenting with synchronous CRLMs, simultaneous colorectal resection and clearing of the less involved hemiliver as the first surgical step is feasible without any negative impact on outcome.

Published
2017
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