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17. Neoplasie occupazionali

Author

Tomei, F., Candura, S. M., Sannolo, N., Sartorelli, P., Costa, G., Perbellini, L., LARESE FILON, F., Magrini, A., Bartolucci, G. B., Ricci, S, Ciocan, C, Pira, E, and Garzaro, G

Published
2018

18. Mesotelioma Maligno

Author

Tomei, F., Candura, S. M., Sannolo, N., Sartorelli, P., Costa, G., Perbellini, L., LARESE FILON, F., Magrini, A., Bartolucci, G. B., Ricci, S., Ciocan, C, Pira, E, and Garzaro, G

Published
2018

19. Carcinogenicity of some nitrobenzenes and other industrial chemicals

Author

Van den Berg, M, primary, Cattley, R, additional, Cherrie, J W, additional, Dorman, D C, additional, Dunnick, J K, additional, Gohlke, J M, additional, Jinot, J, additional, Käfferlein, H U, additional, Kopylev, L, additional, Matsumoto, M, additional, Nomiyama, T, additional, Ogawa, K, additional, Perbellini, L, additional, Sone, H, additional, Grosse, Y, additional, Guyton, K Z, additional, Schubauer-Berigan, M K, additional, El Ghissassi, F, additional, Bouvard, V, additional, Benbrahim-Tallaa, L, additional, Hall, A, additional, Paul, A, additional, Mattock, H, additional, and Straif, K, additional

Published
2018
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20. Carcinogenicity of some nitrobenzenes and other industrial chemicals

Author

Dunnick, J K, Schubauer-Berigan, M K, Grosse, Y, Straif, K, Jinot, J, Van den Berg, M, Perbellini, L, Nomiyama, T, Gohlke, J M, Bouvard, V, Sone, H, Paul, A, Matsumoto, M, Dorman, D C, Kopylev, L, Cherrie, J W, Benbrahim-Tallaa, L, Ogawa, K, El Ghissassi, F, Mattock, H, Käfferlein, H U, Hall, A, Guyton, K Z, Cattley, R, One Health Toxicologie, dIRAS RA-1, One Health Toxicologie, and dIRAS RA-1

Subjects
03 medical and health sciences, 0302 clinical medicine, Oncology, business.industry, 030220 oncology & carcinogenesis, Environmental chemistry, Medicine, Chemical industry, business, 030210 environmental & occupational health, Carcinogen
Published
2018

21. Carcinogenicity of some nitrobenzenes and other industrial chemicals

Author

One Health Toxicologie, dIRAS RA-1, Dunnick, J K, Schubauer-Berigan, M K, Grosse, Y, Straif, K, Jinot, J, Van den Berg, M, Perbellini, L, Nomiyama, T, Gohlke, J M, Bouvard, V, Sone, H, Paul, A, Matsumoto, M, Dorman, D C, Kopylev, L, Cherrie, J W, Benbrahim-Tallaa, L, Ogawa, K, El Ghissassi, F, Mattock, H, Käfferlein, H U, Hall, A, Guyton, K Z, Cattley, R, One Health Toxicologie, dIRAS RA-1, Dunnick, J K, Schubauer-Berigan, M K, Grosse, Y, Straif, K, Jinot, J, Van den Berg, M, Perbellini, L, Nomiyama, T, Gohlke, J M, Bouvard, V, Sone, H, Paul, A, Matsumoto, M, Dorman, D C, Kopylev, L, Cherrie, J W, Benbrahim-Tallaa, L, Ogawa, K, El Ghissassi, F, Mattock, H, Käfferlein, H U, Hall, A, Guyton, K Z, and Cattley, R

Published
2018

22. Methodology to define biological reference values in the environmental and occupational fields: The contribution of the Italian Society for Reference Values (SIVR)

Author

Aprea, Mc, Scapellato, Ml, Valsania, Mc, Perico, A, Perbellini, L, Ricossa, Mc, Pradella, M, Negri, S, Iavicoli, I, Lovreglio, P, Salamon, F, Bettinelli, M, Apostoli, P., Aprea, Maria Cristina, Scapellato, Maria Luisa, Valsania, Maria Carmen, Perico, Andrea, Perbellini, Luigi, Ricossa, Maria Cristina, Pradella, Marco, Negri, Sara, Iavicoli, Ivo, Lovreglio, Piero, Salamon, Fabiola, Bettinelli, Maurizio, and Apostoli, Pietro

Subjects
xenobiotici, Public Health, Environmental and Occupational Health, General population, general population, quality assurance, xenobiotics, Quality assurance, Biological monitoring, General population, quality assurance, xenobiotics/Popolazione generale, assicurazione della qualità, xenobiotici, Humans, Italy, Occupational Health, Reference Values, Environmental Pollution, xenobiotics/Popolazione generale, Xenobiotic, xenobiotics, assicurazione della qualità, Reference value
Abstract

Background: Biological reference values (RVs) explore the relationships between humans and their environment and habits. RVs are fundamental in the environmental field for assessing illnesses possibly associated with environmental pollution, and also in the occupational field, especially in the absence of established biological or environmental limits. Objectives: The Italian Society for Reference Values (SIVR) determined to test criteria and procedures for the definition of RVs to be used in the environmental and occupational fields. Methods: The paper describes the SIVR methodology for defining RVs of xenobiotics and their metabolites. Aspects regarding the choice of population sample, the quality of analytical data, statistical analysis and control of variability factors are considered. The simultaneous interlaboratory circuits involved can be expected to increasingly improve the quality of the analytical data. Results: Examples of RVs produced by SIVR are presented. In particular, levels of chromium, mercury, ethylenethiourea, 3,5,6-trichloro-2-pyridinol, 2,5-hexanedione, 1-hydroxypyrene and t,t-muconic acid measured in urine and expressed in micrograms/g creatinine (µg/g creat) or micrograms/L (µg/L) are reported. Conclusions: With the proposed procedure, SIVR intends to make its activities known to the scientific community in order to increase the number of laboratories involved in the definition of RVs for the Italian population. More research is needed to obtain further RVs in different biological matrices, such as hair, nails and exhaled breath. It is also necessary to update and improve the present reference values and broaden the portfolio of chemicals for which RVs are available. In the near future, SIVR intends to expand its scientific activity by using a multivariate approach for xenobiotics that may have a common origin, and to define RVs separately for children who may be exposed more than adults and be more vulnerable.

Published
2017

32. Trends in the prevalence of asthma and allergic rhinitis in Italy between 1991 and 2010

Author

de Marco R, Cappa V, Accordini S, Rava M, Antonicelli L, Bortolami O, Braggion M, Bugiani M, Casali L, Cazzoletti L, Cerveri I, Fois AG, Girardi P, Locatelli F, Marcon A, Marinoni A, Panico MG, Pirina P, Villani S, Zanolin ME, Verlato G, the GEIRD Study Group: de Marco, R., Verlato, G., Zanolin, M., Accordini, S., Bortolami, O., Braggion, M., Cappa, V., Cazzoletti, L., Girardi, P., Locatelli, F., Marcon, A., Montoli, E., Rava, M., Vesentini, R., Ferrari, M., Donatelli, L., Posenato, C., Cascio, V., Perbellini, L., Olivieri, M., D'Amato, J., Donatini, E., Martinelli, M., Pignatti, P., Bombieri, C., Bettin, M., Trabetti, E., Poli, A., Nicolis, M., Sembeni, S., Antonicelli, L., Bonifazi, F., Attena, F., Galdo, V., Cerveri, I., Corsico, A., Albicini, F., Grosso, A., Marinoni, A., Villani, S., Ferretti, V., Casali, L., Miniucchi, A., Briziarelli, L., Marcarelli, M., Panico, M., Pirina, P., Fois, A., Becciu, F., Deledda, A., Spada, V., Bugiani, M., Carosso, A., Piccioni, P., Castiglioni, G., Bono, R., Tassinari, R., Romanazzi, V., Rolla, G., Heffler, E., Migliore, E., BELLIA, Vincenzo, BATTAGLIA, Salvatore, de Marco R, Cappa V, Accordini S, Rava M, Antonicelli L, Bortolami O, Braggion M, Bugiani M, Casali L, Cazzoletti L, Cerveri I, Fois AG, Girardi P, Locatelli F, Marcon A, Marinoni A, Panico MG, Pirina P, Villani S, Zanolin ME, Verlato G, and the GEIRD Study Group: de Marco, R., Verlato, G., Zanolin, M., Accordini, S., Bortolami, O., Braggion, M., Cappa, V., Cazzoletti, L., Girardi, P., Locatelli, F., Marcon, A., Montoli, E., Rava, M., Vesentini, R., Ferrari, M., Donatelli, L., Posenato, C., Cascio, V., Perbellini, L., Olivieri, M., D'Amato, J., Donatini, E., Martinelli, M., Pignatti, P., Bombieri, C., Bettin, M., Trabetti, E., Poli, A., Nicolis, M., Sembeni, S., Antonicelli, L., Bonifazi, F., Attena, F., Galdo, V., Bellia, V., Battaglia, S., Cerveri, I., Corsico, A., Albicini, F., Grosso, A., Marinoni, A., Villani, S., Ferretti, V., Casali, L., Miniucchi, A., Briziarelli, L., Marcarelli, M., Panico, M., Pirina, P., Fois, A., Becciu, F., Deledda, A., Spada, V., Bugiani, M., Carosso, A., Piccioni, P., Castiglioni, G., Bono, R., Tassinari, R., Romanazzi, V., Rolla, G., Heffler, E., and Migliore, E.

Subjects
Male, Pediatrics, Cross-sectional study, 95% CI 1.19-1.59) from 1998-2000 to 2007-2010, but since then there has been no clear temporal pattern. The present study aimed to assess time trends in the prevalence of current asthma, Abstract The prevalence of asthma increased worldwide until the 1990s, temporal trends, Surveys and Questionnaires, Epidemiology, Surveys and Questionnaire, Medicine, asthma-like symptoms and allergic rhinitis in Italian adults from 1990 to 2010. The same screening questionnaire was administered by mail or phone to random samples of the general population (age 20-44 yrs) in Italy, Young adult, respectively. The prevalence of current asthma was stable during the 1990s and increased (relative risk 1.38, from 10.1% to 13.9% and from 16.8% to 25.8%, education.field_of_study, Allergic rhinitis, Asthma, Prevalence, Temporal trends, Wheezing, medicine.diagnostic_test, Smoking, the median prevalence of current asthma, allergic rhinitis, asthma, epidemiology, prevalence, temporal trends, wheezing, Italy, Abstract The prevalence of asthma increased worldwide until the 1990s, but since then there has been no clear temporal pattern. The present study aimed to assess time trends in the prevalence of current asthma, asthma-like symptoms and allergic rhinitis in Italian adults from 1990 to 2010. The same screening questionnaire was administered by mail or phone to random samples of the general population (age 20-44 yrs) in Italy, in the frame of three multicentre studies: the European Community Respiratory Health Survey (ECRHS) (1991-1993, n=6,031), the Italian Study on Asthma in Young Adults (ISAYA) (1998-2000, n=18,873), and the Gene Environment Interactions in Respiratory Diseases (GEIRD) study (2007-2010, n=10,494). Time trends in prevalence were estimated using Poisson regression models in the centres that repeated the survey at different points in time. From 1991 to 2010, the median prevalence of current asthma, wheezing and allergic rhinitis increased from 4.1% to 6.6%, from 10.1% to 13.9% and from 16.8% to 25.8%, respectively. The prevalence of current asthma was stable during the 1990s and increased (relative risk 1.38, 95% CI 1.19-1.59) from 1998-2000 to 2007-2010, mainly in subjects who did not report allergic rhinitis. The prevalence of allergic rhinitis has increased continuously since 1991. The asthma epidemic is not over in Italy. During the past 20 yrs, asthma prevalence has increased by 38%, in parallel with a similar increase in asthma-like symptoms and allergic rhinitis, mainly in subjects who did not report allergic rhinitis. The prevalence of allergic rhinitis has increased continuously since 1991. The asthma epidemic is not over in Italy. During the past 20 yrs, symbols, asthma prevalence has increased by 38%, Female, epidemiology, Human, Pulmonary and Respiratory Medicine, Adult, 494). Time trends in prevalence were estimated using Poisson regression models in the centres that repeated the survey at different points in time. From 1991 to 2010, in parallel with a similar increase in asthma-like symptoms and allergic rhinitis, medicine.medical_specialty, Rhinitis, Allergic, Perennial, Population, prevalence, Settore MED/10 - Malattie Dell'Apparato Respiratorio, 031), Settore MED/01 - Statistica Medica, symbols.namesake, Young Adult, Allergic rhiniti, Humans, Respiratory sounds, Poisson regression, education, Respiratory Sounds, Cross-Sectional Studie, allergic rhinitis, business.industry, wheezing, wheezing and allergic rhinitis increased from 4.1% to 6.6%, Rhinitis, Allergic, Seasonal, asthma, in the frame of three multicentre studies: the European Community Respiratory Health Survey (ECRHS) (1991-1993, medicine.disease, 873), Cross-Sectional Studies, n=10, Relative risk, Temporal trend, Respiratory Sound, n=6, n=18, business
Abstract

The prevalence of asthma increased worldwide until the 1990s, but since then there has been no clear temporal pattern. The present study aimed to assess time trends in the prevalence of current asthma, asthma-like symptoms and allergic rhinitis in Italian adults from 1990 to 2010. The same screening questionnaire was administered by mail or phone to random samples of the general population (age 20-44 yrs) in Italy, in the frame of three multicentre studies: the European Community Respiratory Health Survey (ECRHS) (1991-1993; n=6,031); the Italian Study on Asthma in Young Adults (ISAYA) (1998-2000; n=18,873); and the Gene Environment Interactions in Respiratory Diseases (GEIRD) study (2007-2010; n=10,494). Time trends in prevalence were estimated using Poisson regression models in the centres that repeated the survey at different points in time. From 1991 to 2010, the median prevalence of current asthma, wheezing and allergic rhinitis increased from 4.1% to 6.6%, from 10.1% to 13.9% and from 16.8% to 25.8%, respectively. The prevalence of current asthma was stable during the 1990s and increased (relative risk 1.38, 95% CI 1.19-1.59) from 1998-2000 to 2007-2010, mainly in subjects who did not report allergic rhinitis. The prevalence of allergic rhinitis has increased continuously since 1991. The asthma epidemic is not over in Italy. During the past 20 yrs, asthma prevalence has increased by 38%, in parallel with a similar increase in asthma-like symptoms and allergic rhinitis. Copyright©ERS 2012.

Published
2012

33. Linee Guida per la prevenzione dei disturbi e delle patologie muscoloscheletriche del rachide da movimentazione manuale dei carichi

Author

Violante, Fs, Bonfiglioli, R., Graziosi, F., Stefano Mattioli, Brach Del Prever, E., Baracco, A., Romano, C., Perbellini, L., Bovenzi, M., Draicchio, F., Baldasseroni, A., Camagni, A., Curti, S., Farioli, A., Zanardi, F., Apostoli, P., Violante FS, Bonfiglioli R, Graziosi F, Mattioli S, Brach del Prever E, Baracco A, Romano C, Perbellini L, Bovenzi M, Draicchio F, Baldasseroni A, Camagni A, Curti S, Farioli A, Zanardi F, and Apostoli P

Subjects
Economica, VALUTAZIONE DEL RISCHIO, movimentazione manuale carichi, Socio-culturale, DISTURBI MUSCOLOSCHELETRICI
Abstract

La prima edizione delle Linee Guida SIMLII sul rischio associato alla movimentazione manuale di carichi è stata pubblicata nel maggio 2004. Da allora sia in campo scientifico che legislativo si sono verificate numerose novità che hanno imposto una nuova edizione delle Linee Guida stesse. La movimentazione manuale di carichi è un compito lavorativo (e non) che può essere associato a un rischio per la salute (a causa di un possibile sovraccarico biomeccanico) e di questo un medico del lavoro dovrebbe comunque occuparsi, indipendentemente dall’eventuale esistenza di specifici obblighi normativi.

Published
2012

34. New biomarkers of exposure

Author

Apostoli, P., Bergonzi, R., Catalani, S., Neri, G., Sarnico, M., Foà, V., Fustinoni, S., Colombi, A., Buratti, M., Campo, L., Scibetta, L., Sannolo, N., Pieri, M., Basile, A., Bartolucci, G. B., Carrieri, M., Scapellato, M. L., Manini, P., Poli, D., Corradi, M., Andreoli, R., Goldoni, M., Mutti, A., Imbriani, M., Ghittori, S., Maestri, L., Negri, S., Pira, Enrico, Pavan, I., Discalzi, G., Perbellini, L., Apostoli, P, Bergonzi, R, Catalani, S, Neri, G, Sarnico, M, Foa, V, Fustinoni, S, Colombi, A, Buratti, M, Campo, L, Scibetta, L, Sannolo, Nicola, Pieri, M, Basile, A, Bartolucci, Gb, Carrieri, M, Scapellato, Ml, Manini, P, Poli, D, Corradi, M, Andreoli, R, Goldoni, M, Mutti, A, Imbriani, M, Ghittori, S, Maestri, L, Negri, S, Pira, E, Pavan, I, Discalzi, G, and Perbellini, L.

Subjects
Cost-Benefit Analysis, Research, Risk Assessment, Sensitivity and Specificity, Rats, Occupational Diseases, biological monitoring, exposure biomarkers, Reference Values, Occupational Exposure, Animals, Humans, risk assessment, occupational health, Occupations, Biomarkers, Occupational Health, Environmental Monitoring, Forecasting
Abstract

In this paper we have defined the new biomarkers of exposure (NBE) as those biomarkers discovered in the last five years and, among previously validated biomarkers, also those applied in different ranges of doses or those determined in biological matrices which differ from matrices originally considered. We examined the results from the surveys carried out by the main Italian research units involved in biological monitoring, i.e. those from the Universities of Brescia, Milan, Naples, Padua, Parma, Pavia, Turin and Verona. The data were collected using a standardized model and included the following: type of element or organic compound, type of biomarker, analytical technique and method, their relationship with environmental monitoring data, their relationship with effect indicators or effects in general, improvement with respect to old biomarkers, reference values. Twenty two NBEs were identified: 14 elements and chemical compounds as such or as metabolites, 4 examples of mixtures, 3 of new matrices, one of speciation. Among the others, aspects such as interest in requiring NBE, quality assurance, availability, cost-benefit ratio were discussed. We conclude that development of this specific field of research appears to be a crucial point for future improvement in risk assessment and health surveillance procedures.

Published
2004

35. New biomarkers of exposure [Nuovi indicatori di esposizione]

Author

Apostoli, P., Bergonzi, R., Catalani, S., Neri, G., Sarnico, M., Foà, V., Fustinoni, S., Colombi, A., Buratti, M., Campo, L., Scibetta, L., Sannolo, N., Pieri, M., Basile, A., Bartolucci, G. B., Carrieri, M., Scapellato, M. L., Manini, P., Poli, D., Corradi, M., Andreoli, R., Goldoni, M., Mutti, A., Imbriani, M., Ghittori, S., Maestri, L., Sara Negri, Pira, E., Pavan, I., Discalzi, G., Perbellini, L., Apostoli, P., Bergonzi, R., Catalani, S., Neri, G., Sarnico, M., Foà, V., Fustinoni, S., Colombi, A., Buratti, Marco, Campo, L., Scibetta, L., Sannolo, N., Pieri, M., Basile, A., Bartolucci, G. B., Carrieri, Miriam, Scapellato, M. L., Manini, P., Poli, Diego, Corradi, Antonio, Andreoli, Massimiliano, Goldoni, M., Mutti, A., Imbriani, M., Ghittori, S., Maestri, Alberto, Negri, Lucia, Pira, Francesco, Pavan, Ilaria, Discalzi, G., and Perbellini, L.

Published
2004

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