331 results on '"Pera C"'
Search Results
2. A New Strategy for Analysis and Visualization of Massively Parallel Computations of Turbulent and Transitional Flows
- Author
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Cadiou, A., Buffat, M., Di Pierro, B., Penven, L. Le, Pera, C., Schröder, Wolfgang, General editor, Boersma, Bendiks Jan, Series editor, Fujii, Kozo, Series editor, Haase, Werner, Series editor, Hirschel, Ernst Heinrich, Founded by, Leschziner, Michael A., Series editor, Periaux, Jacques, Series editor, Pirozzoli, Sergio, Series editor, Rizzi, Arthur, Series editor, Roux, Bernard, Series editor, Shokin, Yurii I., Series editor, Deville, Michel O., editor, Couaillier, Vincent, editor, Estivalezes, Jean-Luc, editor, Gleize, Vincent, editor, HiêpLê, Thiên, editor, Terracol, Marc, editor, and Vincent, Stéphane, editor
- Published
- 2018
- Full Text
- View/download PDF
3. A complex chemical kinetic mechanism for the oxidation of gasoline surrogate fuels: n heptane, iso octane and toluene - Mechanism development and validation
- Author
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Da Cruz, A. Pires, Pera, C., Anderlohr, Jörg, Bounaceur, Roda, and Battin-Leclerc, Frédérique
- Subjects
Physics - Chemical Physics - Abstract
The development and validation against experimental results of a new gasoline surrogate complex kinetic mechanism is presented in this paper. The surrogate fuel is a ternary mixture of n heptane, iso octane and toluene. The full three components mechanism is based on existing n heptane/iso octane (gasoline PRF) and toluene mechanisms which were modified and coupled for the purpose of this work. Mechanism results are compared against available experimental data from the literature. Simulations with the PRF plus toluene mechanism show that its behavior is in agreement with experimental results for most of the tested settings. These include a wide variety of thermodynamic conditions and fuel proportions in experimental configurations such as HCCI engine experiments, rapid compression machines, a shock tube and a jet stirred reactor., Comment: Proceedings of the European Combustion Meeting 2007, Chania : Gr\`ece (2007)
- Published
- 2009
4. Are all people with diabetes and cardiovascular risk factors or microvascular complications at very high risk? Findings from the Risk and Prevention Study
- Author
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Marzona, Irene, Avanzini, Fausto, Lucisano, Giuseppe, Tettamanti, Mauro, Baviera, Marta, Nicolucci, Antonio, Roncaglioni, Maria Carla, Tombesi, M., Tognoni, G., Massa, E., Marrocco, W., Micalella, M., Caimi, V., Longoni, P., Avanzini, F., Franzosi, M. G., Roncaglioni, M. C., Marzona, I., Baviera, M., Monesi, L., Pangrazzi, I., Barlera, S., Milani, V., Nicolis, E., Casola, C., Clerici, F., Palumbo, A., Sgaroni, G., Marchioli, R., Silletta, M. G., Pioggiarella, R., Scarano, M., Marfisi, R. M., Flamminio, A., Macino, L., Ferri, B., Pera, C., Polidoro, A., Abbatino, D., Acquati, M., Addorisio, G., Adinolfi, D., Adreani, L., Agistri, M. R., Agneta, A., Agnolio, M. L., Agostini, N., Agostino, G., Airò, A., Alaimo, N., Albano, M., Albano, N., Alecci, G., Alemanno, S., Alexanian, A., Alfarano, M., Alfè, L., Alonzo, N., Alvino, S., Ancora, A., Andiloro, S., Andreatta, E., Angeli, S., Angiari, F., Angilletti, V., Annicchiarico, C., Anzivino, M., Aprea, R., Aprile, A., Aprile, E., Aprile, I., Aprile, L., Armellani, V., Arnetoli, M., Aronica, A., Autiero, V., Bacca, G., Baccalaro, A. M., Bacci, M., Baglio, G., Bagnani, M., Baiano, A., Baldari, A., Ballarini, L., Banchi, G., Bandera, R., Bandini, F., Baratella, M., Barbieri, A., Barbieri Vita, A., Bardi, M., Barlocchi, M., Baron, P., Bartoli, M., Basile, A., Basile, F., Basile, S., Battaggia, A., Battaglia, A., Baù, A., Beconcini, G., Beggio, R., Belfiore, P. A., Belicchi, M., Bellamoli, S., Bellini, C., Bellomo, M., Benetollo, C., Benetti, R., Beretta, E., Bertalero, P., Bertaso, F. G., Bertolani, U., Bettelli, G., Biagiotti, G., Bianchi, S., Bianco, G., Biccari, F., Bigioli, F., Bindi, M., Bisanti, G., Bitetti, E. M., Blasetti, M. P., Blesi, F., Boato, V., Boga, S., Boidi, E., Boldrin, G., Bollati, A., Bolzan, L., Bolzonella, S., Bonardi, P., Bonato, G. B., Bonci, M., Bonfitto, G., Bonincontro, E., Boninsegna, F., Bonissone, D., Bono, L., Bonollo, E., Borghi, M., Borioli, N., Borsatto, M., Bosco, T., Bosisio Pioltelli, M., Botarelli, C., Botassis, S., Bottini, F., Bottos, C., Bova, G., Bova, V., Bozzani, A., Bozzetto, R. M., Braga, V. T., Braglia, M., Bramati, E., Brazzoli, C., Breglia, G., Brescia, A., Briganti, D., Brigato, G., Brocchi, A., Brosio, F. A., Bruni, E., Buscaglia, E., Bussini, M. D., Bussotti, A., Buzzaccarini, F., Buzzatti, A., Caccamo, G., Cacciavillani, C., Caggiano, G., Caimi, V., Calciano, F. P., Calderisi, M., Calienno, S., Caltagirone, P., Calzolari, I., Cammisa, M., Campanaro, M., Campanella, G. B., Campese, F., Canali, G., Candiani, D. E. L., Canepa, R., Canini, D., Canino, A., Cantoro, E. A., Capilupi, V., Capotosto, P., Cappelli, B., Capraro, G., Carafa, F. A., Carano, Q., Carcaterra, V., Carriero, D., Carrozzo, G., Cartanese, M., Casalena, M., Casarola, M., Caso, C., Casotto, M., Castaldi, F., Castegnaro, R., Castellani, G., Castri, S., Catalano, E., Catinello, N., Caturano, G., Cavallaro, R., Cavallo, A. M., Cavallo, G., Cavion, M. T., Cavirani, G., Cazzaniga, F., Cazzetta, D., Cecconi, V., Cefalo, A., Celebrano, M., Celora, A., Centonze, P., Cerati, D., Cesaretti, D., Checchia, G., Checchin, A., Cherubini, M., Chianese, L., Chiappa, A., Chiappa, M. V., Chiariello, G., Chiavini, G., Chicco, M., Chiumeo, F., Ciacciarelli, A., Ciaci, D., Ciancaglini, R., Cicale, C., Cicale, S., Cipolla, A., Ciruolo, A., Citeri, A. L., Citterio, G., Clerici, M., Coazzoli, E., Collecchia, G., Colletta, F., Colombo, I., Colorio, P., Coluccia, S., Comerio, M., Comoretto, P., Compagni, M., Conte, O., Contri, S., Contrisciani, A., Coppetti, T., Corasaniti, F., Corradi, M. T., Corsano, A., Corsini, A., Corti, N., Costantini, G., Costantino, A., Cotroneo, S., Cozzi, D., Cravello, M. G., Cristiano, E., Cucchi, R., Cusmai, L., D’Errico, G. B., D’Agostino, P., Dal Bianco, L., Dal Mutto, U., Dal Pozzo, G., Dallapiccola, P., Dallatorre, G., Dalle Molle, G., Dalloni, E., D’Aloiso, A., D’Amicis, G., Danese, R., Danieli, D., Danisi, G., D’Anna, M. A., Danti, G., D’Ascanio, S., Davidde, G., De Angeli, D., De Bastiani, R., De Battisti, A., De Bellis, A., De Berardinis, G., De Carlo, F., De Giorgi, D., De Gobbi, R., De Lorenzis, E., De Luca, P., De Martini, G., De Marzi, M., De Matteis, D., De Padova, S., De Polo, P., De Sabato, N., De Stefano, T., De Vita, M. T., De Vito, U., De Zolt, V., Debernardi, F., Del Carlo, A., Del Re, G., Del Zotti, F., D’Elia, R., Della Giovanna, P., Dell’Acqua, L., Dell’Orco, R. L., Demaria, G., Di Benedetto, M. G., Di Chiara, G., Di Corcia, V., Di Domizio, O., Di Donato, P., Di Donato, S., Di Fermo, G., Di Franco, M., Di Giovannantonio, G., Di Lascio, G., Di Lecce, G., Di Lorenzo, N., Di Maro, T., Di Mattia, Q., Di Michele, E., Di Modica, R. S., Di Murro, D., Di Noi, M. C., Di Paoli, V., Di Santi, M., Di Sanzo, A., Di Turi, C., Diazzi, A., Dileo, I., D’Ingianna, A. P., Dolci, A., Donà, G., Donato, C., Donato, P., Donini, A., Donna, M. E., Donvito, T. V., Esposito, L., Esposito, N., Evangelista, M., Faita, G., Falco, M., Falcone, D. A., Falorni, F., Fanciullacci, A., Fanton, L., Fasolo, L., Fassina, R., Fassone, A., Fatarella, P., Fedele, F., Fera, I., Fera, L., Ferioli, S., Ferlini, M. G., Ferlino, R., Ferrante, G., Ferrara, F. N., Ferrarese, M. F., Ferrari, G., Ferrari, O., Ferreri, A., Ferroni, M., Fezzi, G., Figaroli, C., Fina, M. G., Fioretta, A., Fiorucci, C., Firrincieli, R., Fischetti, M., Fischietti, G., Fiume, D. C., Flecchia, G., Forastiere, G., Fossati, B., Franceschi, P. L., Franchi, L., Franzoso, F., Frapporti, G., Frasca, G., Frisotti, A., Fumagalli, G., Fusco, D., Gabriele, P., Gabrieli, A., Gagliano, D., Galimberti, G., Galli, A., Gallicchio, N., Gallio, F., Gallipoli, T., Gallo, P., Galopin, T., Gambarelli, L., Garbin, A., Garozzo, G. M., Gasparri, R., Gastaldo, M., Gatti, E., Gazzaniga, P., Gennachi, N., Gentile, R. V., Germani, P., Gesualdi, F., Gherardi, E., Ghezzi, C., Ghidini, M. G., Ghionda, F., Giacci, L., Gialdini, D., Giampaolo, C., Giancane, R., Giannanti, A., Giannese, S., Giannini, L., Giaretta, M., Giaretta, R., Giavardi, L., Giordano, P., Giordano, E., Giordano, B., Gioria, G. M., Giugliano, R., Grassi, E. A., Greco, A., Greco, L., Grilletti, N., Grimaldi, N., Grisetti, G., Groppelli, G., Gualtieri, L., Guarducci, M., Guastella, G., Guerra, M., Guerrini, F., Guglielmini, A., Guido, A., Gulotta, P., Iacono, E., Iadarola, G., Ianiro, G., Iarussi, V., Ieluzzi, M. L., Ierardi, C., Ingaldi, F., Interlandi, S., Iocca, M., Iorno, A., Ioverno, E., Iurato, R., La Pace, L., La Piscopia, C., La Selva, R., Lafratta, M., Lamparelli, M., Lanaro, G., Lancerotto, R., Larcher, M., Lassandro, M., Lattuada, G., Laurino, P., Lefons, C., Legrottaglie, F., Lemma, A., Leone, D., Leone, F., Leso, A., Leuzzi, G., Levato, G., Libardi, L., Libralesso, N., Licini, P. I., Licursi, G., Lidonnici, F., Lillo, C., Liveri, L., Livio, A., Loiero, R. A., Loison, M., Lombardo, G., Lombardo, T., Lomunno, V., Lomuscio, S., Lonedo, A., Longo, E., Longoni, P., Lora, L., Lotterio, A., Lucatello, L., Luongo, A., Lupoli, M., Macchia, C., Macri, G., Mafessanti, M., Maggialetti, V., Maggioni, A., Magnani, M., Maiellaro, G., Mancuso, A., Maniglio, A. R., Mannari, G. L., Manni, A., Manocchio, B., Mao, M., Maranò, A., Maraone, E., Marascio, D., Marcheselli, P., Marchetto, B., Marchetto, S., Marchi, A., Marchi, G. L., Mariano, C., Marinacci, S., Marinelli, S., Marini, G., Marra, V. C., Marrali, F., Marseglia, C., Martello, G., Martino, C., Martino, G., Martino, M., Marulli, C. F., Maruzzi, G., Marzotti, A., Mascheroni, G., Mascolo, P., Masoch, G., Masone, R., Massa, E., Massa, L., Massafra, M., Massi, M., Massignani, D. M., Matarese, A. M., Matini, G., Mauro, R., Mazzi, M., Mazzillo, A., Mazzocato, E., Mazzoleni, N. S., Mazzone, A., Melacci, A., Mele, E., Meliota, P., Menaspà, S., Meneghello, F., Merola, G., Merone, L., Metrucci, A., Mezzina, V., Micchi, A., Michielon, A., Migliore, N., Minero, G., Minotta, F., Mirandola, C., Mistrorigo, S., Modafferi, L., Moitre, R., Mola, E., Monachese, C., Mongiardini, C., Montagna, F., Montani, M., Montemurno, I., Montolli, R., Montorsi, S., Montresor, M., Monzani, M. G., Morabito, F., Mori, G., Moro, A., Mosca, M. F., Motti, F., Muddolon, L., Mugnai, M., Muscas, F., Naimoli, F., Nanci, G., Nargi, E., Nasorri, R., Nastrini, G., Negossi, M., Negrini, A., Negroni, A., Neola, V., Niccolini, F., Niro, C. M., Nosengo, C., Novella, G., Nuti, C., Obici, F., Olita, C., Oliverio, S. S., Olivieri, I., Oriente, S., Orlando, G., Paci, C., Pagano, G., Pagliara, C., Paita, G., Paladini, G., Paladino, G., Palano, T., Palatella, A., Palermo, P., Palmisano, M., Pando, P., Panessa, P., Panigo, F., Panozzo, G., Panvini, F., Panzieri, F., Panzino, A., Panzitta, F., Paoli, N., Papagna, R., Papaleo, M. G., Papalia, G., Parisi, R., Parotti, N., Parravicini, D., Passarella, P., Pastore, G. A., Patafio, M., Pavone, P., Pedroli, W., Pedroni, M., Pelligra, G., Pellizzari, M., Penati, A., Perlot, M., Perrone, A., Perrone, G., Peruzzi, P., Peselli, C., Petracchini, L., Petrera, L., Petrone, S., Peverelli, C., Pianorsi, F., Piazza, G. P., Piazzolla, G., Picci, A., Pienabarca, G., Pietronigro, T. P., Pignocchino, P., Pilone, R., Pinto, D., Pirovano, E., Pirrotta, D., Pisante, V., Pitotto, P., Pittari, L., Piva, A., Pizzoglio, A., Plantera, O. R., Plebani, W., Plessi, S., Podrecca, D., Poerio, V., Poggiani, F., Pogliani, W., Poli, L., Poloni, F. G., Porcelli, R., Porto, S., Pranzo, L., Prevedello, C., Profeta, C., Profico, D., Punzi, A., Quaglia, G. M., Racano, M., Raccone, A., Radice, F., Raho, C. A., Raimondi, R., Rainò, M., Ramponi, R., Ramunni, A., Ramunni, A. L., Ravasio, F., Ravera, M., Re Sartò, G., Rebustello, G., Regazzoli, S., Restelli, C., Rezzonico, M., Ricchiuto, F., Rigo, S., Rigon, G., Rigon, R., Rinaldi, O. V., Rinaldi, M., Risplendente, P. G., Rispoli, M., Riundi, R., Riva, M. G., Rizzi, A. L., Rizzi, D., Rizzo, L. D., Rocchi, L., Rondinone, B., Rosa, B., Rosati, F., Roselli, F., Rossetti, A., Rossetti, C., Rossi, R., Rossi, P. R., Rossi, A., Rossi, C. L., Rossitto, A., Ruffini, R., Ruffo, A., Ruggio, S., Ruo, M., Russo, B., Russo, L., Russo, R., Russo, S., Russo, U., Russo, V., Ruta, G., Sacchi, F., Sacco Botto, F., Saia, A., Salladini, G., Salmoiraghi, S., Saluzzo, F., Salvatore, C., Salvatori, E., Salvio, G., Sandri, P., Sandrini, T., Sangermano, V., Santoni, N., Saracino, A. D., Saracino, A., Sarasin, P., Sardo Infirri, C., Sarrì, B., Sartori, G., Sartori, N., Sauro, C., Scaglioni, M., Scalfi, C., Scamardella, A. M., Scandale, G., Scandone, L., Scannavini, G., Scarati, R., Scardi, A., Scarpa, F. M., Scazzi, P., Schifone, A., Schiroso, G., Scigliano, G., Scilla, A., Sciortino, M., Scolaro, G., Scollo, E., Scorretti, G., Sellitti, R., Selmo, A., Selvaggio, G., Sempio, A., Seren, F., Serio, L., Serra, C., Serra, L., Siciliano, D., Sideri, A., Sighele, M., Signore, R., Siliberto, F., Silvestro, M., Simioni, G., Simmini, G., Simonato, L., Sinchetto, F., Sizzano, E., Smajato, G., Smaldone, M., Sola, G., Sordillo, L., Sovran, C. S., Spagnul, P., Spanò, F., Sproviero, S., Squintani, A., Stella, L., Stilo, V., Stocchiero, B., Stornello, M. C., Stracka, G., Strada, S., Stranieri, G., Stucci, N., Stufano, N., Suppa, A., Susca, V. G., Sutti, M., Taddei, M., Tagliabue, E., Tagliente, G., Talato, F., Talerico, P., Talia, R., Taranto, R., Tartaglia, M., Tauro, N., Tedesco, A., Tieri, P., Tirelli, M., Tocci, L., Todesco, P., Tognolo, M., Tomba, A., Tonello, P., Tonon, R., Toscano, L., Tosi, A., Tosi, G., Toso, S., Travaglio, P., Tremul, L., Tresso, C., Triacchini, P., Triggiano, L., Trigilio, A., Trimeloni, J., Tripicchio, G., Tritto, G. S., Trono, F., Trotta, E., Trotta, G., Tubertini, A., Turri, C., Turri, L., Tuttolani, M. P., Urago, M., Ursini, G., Valcanover, F., Valente, L., Valenti, M., Valentini, F., Vallone, G., Valz, P., Valzano, L., Vanin, V., Vatteroni, M., Vegetti, L., Vendrame, D., Veramonti, I., Veronelli, G., Vesco, A., Vicariotto, G., Vignale, G., Villa, P. L., Vinciguerra, R., Visco, A., Visentin, G., Visonà, E., Vitali, E., Vitali, S., Vitti, F., Volpone, D. A., Zambon, N., Zammarrelli, A., Zanaboni, A., Zane, D., Zanetti, B., Zanibellato, R., Zappetti, M., Zappone, P., Zerilli, G., Zirino, V., Zoccali, R., Zuin, F., Altomonte, M., Anelli, N., Angiò, F., Annale, P., Antonacci, S., Anzilotta, R., Bano, F., Basadonna, O., Beduschi, L., Becagli, P., Bellotti, G., Blotta, C., Bruno, G., Cappuccini, A., Caramatti, S., Cariolato, M. P., Castellana, M., Castellani, L., Catania, R., Chielli, A., Chinellato, A., Ciaccia, A., Clerici, E., Cocci, A., Costanzo, G., D’Ercole, F., De Stefano, G., Decè, F., Di Cicco, N., Di Marco, A., Donati Sarti, C., Draghi, E., Dusi, G., Esposito, V., Ferraro, L., Ferretti, A., Ferri, E., Foggetti, L., Foglia, A., Fonzi, E., Frau, G., Fuoco, M. R., Furci, G., Gallo, L., Garra, V., Giannini, A., Gris, A., Iacovino, R., Interrigi, R., Joppi, R., Laner, B., La Fortezza, G., La Padula, A., Lista, M. R., Lupi, G., Maffei, D., Maggioni, G., Magnani, L., Marrazzo, E., Marcon, L., Marinò, V., Maroni, A., Martinelli, C., Mastandrea, E., Mastropierro, F., Meo, A. T., Mero, P., Minesso, E., Moschetta, V., Mosele, E., Nanni, C., Negretti, A., Nisticò, C., Orsini, A., Osti, M., Pacilli, M. C., Pennestre, C., Picerno, G., Piol, K., Pivano, L., Pizzuti, E., Poggi, L., Poidomani, I., Pozzetto, M., Presti, M. L., Ravani, R., Recalenda, V., Romagnuolo, F., Rossignoli, S., Rossin, E., Sabatella, C., Sacco, F., Sanità, F., Sansone, E., Servadei, F., Sisto, M. T., Sorio, A., Sorrentino, A., Spinelli, E., Spolaor, A., Squillacioti, A., Stella, P., Talerico, A., Todisco, C., Vadino, M., Zuliani, C., and Risk & Prevention Collaborative Group
- Published
- 2017
- Full Text
- View/download PDF
5. A New Strategy for Analysis and Visualization of Massively Parallel Computations of Turbulent and Transitional Flows
- Author
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Cadiou, A., primary, Buffat, M., additional, Di Pierro, B., additional, Penven, L. Le, additional, and Pera, C., additional
- Published
- 2017
- Full Text
- View/download PDF
6. Direct numerical simulation of particle transport by hairpin vortices in a laminar boundary layer
- Author
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Prevel, M., Vinkovic, I., Doppler, D., Pera, C., and Buffat, M.
- Published
- 2013
- Full Text
- View/download PDF
7. LES study of cycle-to-cycle variations in a spark ignition engine
- Author
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Enaux, B., Granet, V., Vermorel, O., Lacour, C., Pera, C., Angelberger, C., and Poinsot, T.
- Published
- 2011
- Full Text
- View/download PDF
8. Establishment of a Pediatric Liver Transplantation Program: Experience With 100 Transplantation Procedures
- Author
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Ciria, R., Sánchez-Hidalgo, J.M., Briceño, J., Naranjo, Á., Pleguezuelo, M., Díaz-Nieto, R., Luque, A., Jiménez, J., García-Menor, E., Gilbert, J.J., de la Mata, M., Pérez-Navero, J.L., Solórzano, G., Rufián, S., Pera, C., and López-Cillero, P.
- Published
- 2009
- Full Text
- View/download PDF
9. In situ analysis and visualization of massively parallel simulations of transitional and turbulent flows In situ analysis and visualization of massively parallel simulations of transitional and turbulent flows
- Author
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Cadiou, A., Buffat, M., Pera, C., Di Pierro, B., Alizard, F., Le Penven, L., Laboratoire de Mecanique des Fluides et d'Acoustique (LMFA), École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
[PHYS.MECA.MEFL]Physics [physics]/Mechanics [physics]/Fluid mechanics [physics.class-ph] - Abstract
International audience; The increase of computational resources with the generalization of massively parallel supercomputers benefits to various fields of physics among which turbulence and fluid mechanics, making it possible to increase time and space accuracy and gain further knowledge in fundamental mechanisms. Parametric studies, high fidelity statistics, high resolutions, can be realized. However, this access poses many problems in terms of data management, analysis and visualization. Traditional workflow, consisting of writing raw data on disks and performing post-processing to extract physical quantities of interest, considerably slows down the analysis, if not becomes impossible, because of data transfer, storage and re-accessibility issues. This is particularly difficult when it comes to visualization. Usage has to be revisited to maintain consistency with the accuracy of the computation step and in this context, in situ processing is a promising approach. We developed an in situ analysis and visualization strategy with an hybrid method for transitional and turbulent flow analysis with a pseudo-spectral solver. It is shown to have a low impact on computational time with a reasonable increase of resource usage, while enriching data exploration. Large time sequences have been analyzed. This could not have been achieved with the traditional workflow. Moreover, computational steering has been performed with real-time adjustment of the simulations, thereby getting closer to a numerical experiment process.
- Published
- 2020
10. Respiratory Needs in Patients with Type 1 Spinal Muscular Atrophy Treated with Nusinersen
- Author
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Sansone, V. A., Pirola, A., Albamonte, E., Pane, M., Lizio, A., D'Amico, A., Catteruccia, M., Cutrera, R., Bruno, C., Pedemonte, M., Messina, S., Rao, F., Roma, E., Salmin, F., Coratti, Giorgia, Di Bari, A., De Sanctis, R., Pera, C. M., Sframeli, M., Piastra, Marco, Macagno, F., Vita, G., Bertini, E., Mercuri, Eugenio Maria, Coratti G. (ORCID:0000-0001-6666-5628), Piastra M. (ORCID:0000-0002-3144-8970), Mercuri E. (ORCID:0000-0002-9851-5365), Sansone, V. A., Pirola, A., Albamonte, E., Pane, M., Lizio, A., D'Amico, A., Catteruccia, M., Cutrera, R., Bruno, C., Pedemonte, M., Messina, S., Rao, F., Roma, E., Salmin, F., Coratti, Giorgia, Di Bari, A., De Sanctis, R., Pera, C. M., Sframeli, M., Piastra, Marco, Macagno, F., Vita, G., Bertini, E., Mercuri, Eugenio Maria, Coratti G. (ORCID:0000-0001-6666-5628), Piastra M. (ORCID:0000-0002-3144-8970), and Mercuri E. (ORCID:0000-0002-9851-5365)
- Abstract
Objective: To evaluate the effects of nusinersen on respiratory function of patients with type 1 spinal muscular atrophy. Study design: Observational, longitudinal cohort study. We collected respiratory data from 118 children with type 1 spinal muscular atrophy and differing pulmonary requirements and conducted a semistructured qualitative interview among a subsample of caregivers at baseline, 6 months, and 10 months after the first nusinersen treatment. Patients were stratified according to ventilation modalities and age at study entry. Results: Most patients in our cohort remained stable (84/109 = 77%). More than 80% of the children treated before age 2 years survived, in contrast to the lower survival reported in natural history studies, and did so without tracheostomy or noninvasive ventilation (NIV) ≥16 hours. In those less than 2 years old, only 3 patients shifted from NIV ≤10 hours to NIV >10 hours, and the other 3 reduced the hours of NIV required. Most of the older patients remained stable; this included not only those on tracheostomy or NIV >10 hours but also 75% of those on NIV ≤10 hours. Conclusions: Our results suggest that nusinersen may produce some improvement in the progression of respiratory impairment, both in terms of survival and need for respiratory support ≥16 hours, especially before the age of 2 years.
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- 2020
11. Direct numerical simulation of spray flame/acoustic interactions
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Pera, C. and Reveillon, J.
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- 2007
- Full Text
- View/download PDF
12. A proposal for scoring marginal liver grafts
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Briceño, J., Solórzano, G., and Pera, C.
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- 2000
- Full Text
- View/download PDF
13. Comparison of stationary vs ambulatory 24-hour pH monitoring systems in diagnosis og gastroesophageal reflux disease
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Grande, L., Culell, P., Ros, E., Lacima, G., Pujol, A., García-Valdecasas, J. C., Fuster, J., Visa, J., and Pera, C.
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- 1993
- Full Text
- View/download PDF
14. Obstructing colorectal carcinomas: Prospective study
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Garcia-Valdecasas, J. C., Llovera, J. M., deLacy, A. M., Reverter, J. C., Grande, L., Fuster, J., Cugat, E., Visa, J., and Pera, C.
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- 1991
- Full Text
- View/download PDF
15. Melatonin versus vitamin E as protective treatment against oxidative stress after extra-hepatic bile duct ligation in rats
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Montilla, P., Cruz, A., Padillo, F. J., Túnez, I., Gascon, F., Muñoz, M. C., Gómez, M., and Pera, C.
- Published
- 2001
16. Identification of ricin A-chain HLA class II-restricted epitopes by human T-cell clones
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Tommasi, M., Castelletti, D., Pasti, M., Fracasso, G., Lorenzetti, I., Sartoris, S., Pera, C., Ferrara, G. B., Tridente, G., and Colombatti, M.
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- 2001
17. Prognostic significance of K-ras, p53, bcl-2, PCNA, CD34 in radically resected non-small cell lung cancers
- Author
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Grossi, F, Loprevite, M, Chiaramondia, M, Ceppa, P, Pera, C, Ratto, G.B, Serrano, J, Ferrara, G.B, Costa, R, Boni, L, and Ardizzoni, A
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- 2003
- Full Text
- View/download PDF
18. Identification of a new DRB3*02 allelic variant (DRB3*0209) by high-resolution sequence-based typing
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Morabito, A., Pera, C., Longo, A., Delfino, L., and Ferrara, G. B.
- Published
- 2000
19. Novel associations among HLA-DQA1 and -DQB1 alleles, revealed by high-resolution sequence-based typing (SBT)
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Pera, C., Delfino, L., Longo, A., Pistillo, M. P., and Ferrara, G. B.
- Published
- 2000
20. CHARACTERIZATION OF AMMINOACIDIC RESIDUES WITH BIOLOGICAL SIGNIFICANCE IN TRANSPLANT REJECTION
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LONGO, A., DELFINO, L., PERA, C., POZZI, S., and FERRARA, G. B.
- Published
- 1998
21. Increased plasma levels of atrial natriuretic peptide and endocrine markers of volume depletion in patients with obstructive jaundice
- Author
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GALLARDO, J. M., PADILLO, J., MARTIN-MALO, A., MINO, G., PERA, C., and SITGES-SERRA, A.
- Published
- 1998
22. HLA-A typing: comparison between serology, the amplification refractory mutation system with polymerase chain reaction and sequencing
- Author
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Pera, C., Delfino, L., Morabito, A., Longo, A., Johnston-Dow, L., White, C. B., Colonna, M., and Ferrara, G. B.
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- 1997
23. C13/14 ASSESSING LATE MORTALITY AFTER LIVER TRANSPLANTATION
- Author
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González-Galilea, A., de la Mata, M., Fraga, E., Montero, J L, Costán, G., Delgado, M., Solórzano, G., López-Cillero, P., Rufián, S., Pera, C., and Miño, G.
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- 1997
24. High amplitude contractions in the middle third of the oesophagus: a manometric marker of chronic alcoholism?
- Author
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Grande, L., Monforte, R., Ros, E., Toledo-Pimentel, V., Estruch, R., Lacima, G., Urbano-Marquez, A., and Pera, C.
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- 1996
25. Prospective Study of 100 Patients with Gastroesophageal Reflux: Prognostic Value of Symptoms, Presence of Esophagitis, and Lower Esophageal Sphincter Pressure
- Author
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Ros, E., Pujol, A., Grande, L., Bordas, J. M., Pera, C., Siewert, J. R., editor, and Hölscher, A. H., editor
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- 1988
- Full Text
- View/download PDF
26. Nocturnal pH-Monitoring in the Diagnosis of Pathological Gastroesophageal Reflux
- Author
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Pujol, A., Grande, L., Ros, E., Pera, C., Siewert, J. R., editor, and Hölscher, A. H., editor
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- 1988
- Full Text
- View/download PDF
27. Are all people with diabetes and cardiovascular risk factors or microvascular complications at very high risk? Findings from the Risk and Prevention Study
- Author
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Marzona, I., Avanzini, F., Lucisano, G., Tettamanti, M., Baviera, M., Nicolucci, A., Roncaglioni, M. C., Tombesi, M., Tognoni, G., Massa, E., Marrocco, W., Micalella, M., Caimi, V., Longoni, P., Franzosi, M. G., Monesi, L., Pangrazzi, I., Barlera, S., Milani, V., Nicolis, E., Casola, C., Clerici, F., Palumbo, A., Sgaroni, G., Marchioli, R., Silletta, M. G., Pioggiarella, R., Scarano, M., Marfisi, R. M., Flamminio, A., Macino, L., Ferri, B., Pera, C., Polidoro, A., Abbatino, D., Acquati, M., Addorisio, G., Adinolfi, D., Adreani, L., Agistri, M. R., Agneta, A., Agnolio, M. L., Agostini, N., Agostino, G., Airo, A., Alaimo, N., Albano, M., Albano, N., Alecci, G., Alemanno, S., Alexanian, A., Alfarano, M., Alfe, L., Alonzo, N., Alvino, S., Ancora, A., Andiloro, S., Andreatta, E., Angeli, S., Angiari, F., Angilletti, V., Annicchiarico, C., Anzivino, M., Aprea, R., Aprile, A., Aprile, E., Aprile, I., Aprile, L., Armellani, V., Arnetoli, M., Aronica, A., Autiero, V., Bacca, G., Baccalaro, A. M., Bacci, M., Baglio, G., Bagnani, M., Baiano, A., Baldari, A., Ballarini, L., Banchi, G., Bandera, R., Bandini, F., Baratella, M., Barbieri, A., Barbieri Vita, A., Bardi, M., Barlocchi, M., Baron, P., Bartoli, M., Basile, A., Basile, F., Basile, S., Battaggia, A., Battaglia, A., Bau, A., Beconcini, G., Beggio, R., Belfiore, P. A., Belicchi, M., Bellamoli, S., Bellini, C., Bellomo, M., Benetollo, C., Benetti, R., Beretta, E., Bertalero, P., Bertaso, F. G., Bertolani, U., Bettelli, G., Biagiotti, G., Bianchi, S., Bianco, G., Biccari, F., Bigioli, F., Bindi, M., Bisanti, G., Bitetti, E. M., Blasetti, M. P., Blesi, F., Boato, V., Boga, S., Boidi, E., Boldrin, G., Bollati, A., Bolzan, L., Bolzonella, S., Bonardi, P., Bonato, G. B., Bonci, M., Bonfitto, G., Bonincontro, E., Boninsegna, F., Bonissone, D., Bono, L., Bonollo, E., Borghi, M., Borioli, N., Borsatto, M., Bosco, T., Bosisio Pioltelli, M., Botarelli, C., Botassis, S., Bottini, F., Bottos, C., Bova, G., Bova, V., Bozzani, A., Bozzetto, R. M., Braga, V. T., Braglia, M., Bramati, E., Brazzoli, C., Breglia, G., Brescia, A., Briganti, D., Brigato, G., Brocchi, A., Brosio, F. A., Bruni, E., Buscaglia, E., Bussini, M. D., Bussotti, A., Buzzaccarini, F., Buzzatti, A., Caccamo, G., Cacciavillani, C., Caggiano, G., Calciano, F. P., Calderisi, M., Calienno, S., Caltagirone, P., Calzolari, I., Cammisa, M., Campanaro, M., Campanella, G. B., Campese, F., Canali, G., Candiani, D. E. L., Canepa, R., Canini, D., Canino, A., Cantoro, E. A., Capilupi, V., Capotosto, P., Cappelli, B., Capraro, G., Carafa, F. A., Carano, Q., Carcaterra, V., Carriero, D., Carrozzo, G., Cartanese, M., Casalena, M., Casarola, M., Caso, C., Casotto, M., Castaldi, F., Castegnaro, R., Castellani, G., Castri, S., Catalano, E., Catinello, N., Caturano, G., Cavallaro, R., Cavallo, A. M., Cavallo, G., Cavion, M. T., Cavirani, G., Cazzaniga, F., Cazzetta, D., Cecconi, V., Cefalo, A., Celebrano, M., Celora, A., Centonze, P., Cerati, D., Cesaretti, D., Checchia, G., Checchin, A., Cherubini, M., Chianese, L., Chiappa, A., Chiappa, M. V., Chiariello, G., Chiavini, G., Chicco, M., Chiumeo, F., Ciacciarelli, A., Ciaci, D., Ciancaglini, R., Cicale, C., Cicale, S., Cipolla, A., Ciruolo, A., Citeri, A. L., Citterio, G., Clerici, M., Coazzoli, E., Collecchia, G., Colletta, F., Colombo, I., Colorio, P., Coluccia, S., Comerio, M., Comoretto, P., Compagni, M., Conte, O., Contri, S., Contrisciani, A., Coppetti, T., Corasaniti, F., Corradi, M. T., Corsano, A., Corsini, A., Corti, N., Costantini, G., Costantino, A., Cotroneo, S., Cozzi, D., Cravello, M. G., Cristiano, E., Cucchi, R., Cusmai, L., D'Errico, G. B., D'Agostino, P., Dal Bianco, L., Dal Mutto, U., Dal Pozzo, G., Dallapiccola, P., Dallatorre, G., Dalle Molle, G., Dalloni, E., D'Aloiso, A., D'Amicis, G., Danese, R., Danieli, D., Danisi, G., D'Anna, M. A., Danti, G., D'Ascanio, S., Davidde, G., De Angeli, D., De Bastiani, R., De Battisti, A., De Bellis, A., De Berardinis, G., De Carlo, F., De Giorgi, D., De Gobbi, R., De Lorenzis, E., De Luca, P., De Martini, G., De Marzi, M., De Matteis, D., De Padova, S., De Polo, P., De Sabato, N., De Stefano, T., De Vita, M. T., De Vito, U., De Zolt, V., Debernardi, F., Del Carlo, A., Del Re, G., Del Zotti, F., D'Elia, R., Della Giovanna, P., Dell'Acqua, L., Dell'Orco, R. L., Demaria, G., Di Benedetto, M. G., Di Chiara, G., Di Corcia, V., Di Domizio, O., Di Donato, P., Di Donato, S., Di Fermo, G., Di Franco, M., Di Giovannantonio, G., Di Lascio, G., Di Lecce, G., Di Lorenzo, N., Di Maro, T., Di Mattia, Q., Di Michele, E., Di Modica, R. S., Di Murro, D., Di Noi, M. C., Di Paoli, V., Di Santi, M., Di Sanzo, A., Di Turi, C., Diazzi, A., Dileo, I., D'Ingianna, A. P., Dolci, A., Dona, G., Donato, C., Donato, P., Donini, A., Donna, M. E., Donvito, T. V., Esposito, L., Esposito, N., Evangelista, M., Faita, G., Falco, M., Falcone, D. A., Falorni, F., Fanciullacci, A., Fanton, L., Fasolo, L., Fassina, R., Fassone, A., Fatarella, P., Fedele, F., Fera, I., Fera, L., Ferioli, S., Ferlini, M. G., Ferlino, R., Ferrante, G., Ferrara, F. N., Ferrarese, M. F., Ferrari, G., Ferrari, O., Ferreri, A., Ferroni, M., Fezzi, G., Figaroli, C., Fina, M. G., Fioretta, A., Fiorucci, C., Firrincieli, R., Fischetti, M., Fischietti, G., Fiume, D. C., Flecchia, G., Forastiere, G., Fossati, B., Franceschi, P. L., Franchi, L., Franzoso, F., Frapporti, G., Frasca, G., Frisotti, A., Fumagalli, G., Fusco, D., Gabriele, P., Gabrieli, A., Gagliano, D., Galimberti, G., Galli, A., Gallicchio, N., Gallio, F., Gallipoli, T., Gallo, P., Galopin, T., Gambarelli, L., Garbin, A., Garozzo, G. M., Gasparri, R., Gastaldo, M., Gatti, E., Gazzaniga, P., Gennachi, N., Gentile, R. V., Germani, P., Gesualdi, F., Gherardi, E., Ghezzi, C., Ghidini, M. G., Ghionda, F., Giacci, L., Gialdini, D., Giampaolo, C., Giancane, R., Giannanti, A., Giannese, S., Giannini, L., Giaretta, M., Giaretta, R., Giavardi, L., Giordano, P., Giordano, E., Giordano, B., Gioria, G. M., Giugliano, R., Grassi, E. A., Greco, A., Greco, L., Grilletti, N., Grimaldi, N., Grisetti, G., Groppelli, G., Gualtieri, L., Guarducci, M., Guastella, G., Guerra, M., Guerrini, F., Guglielmini, A., Guido, A., Gulotta, P., Iacono, E., Iadarola, G., Ianiro, G., Iarussi, V., Ieluzzi, M. L., Ierardi, C., Ingaldi, F., Interlandi, S., Iocca, M., Iorno, A., Ioverno, E., Iurato, R., La Pace, L., La Piscopia, C., La Selva, R., Lafratta, M., Lamparelli, M., Lanaro, G., Lancerotto, R., Larcher, M., Lassandro, M., Lattuada, G., Laurino, P., Lefons, C., Legrottaglie, F., Lemma, A., Leone, D., Leone, F., Leso, A., Leuzzi, G., Levato, G., Libardi, L., Libralesso, N., Licini, P. I., Licursi, G., Lidonnici, F., Lillo, C., Liveri, L., Livio, A., Loiero, R. A., Loison, M., Lombardo, G., Lombardo, T., Lomunno, V., Lomuscio, S., Lonedo, A., Longo, E., Lora, L., Lotterio, A., Lucatello, L., Luongo, A., Lupoli, M., Macchia, C., Macri, G., Mafessanti, M., Maggialetti, V., Maggioni, A., Magnani, M., Maiellaro, G., Mancuso, A., Maniglio, A. R., Mannari, G. L., Manni, A., Manocchio, B., Mao, M., Marano, A., Maraone, E., Marascio, D., Marcheselli, P., Marchetto, B., Marchetto, S., Marchi, A., Marchi, G. L., Mariano, C., Marinacci, S., Marinelli, S., Marini, G., Marra, V. C., Marrali, F., Marseglia, C., Martello, G., Martino, C., Martino, G., Martino, M., Marulli, C. F., Maruzzi, G., Marzotti, A., Mascheroni, G., Mascolo, P., Masoch, G., Masone, R., Massa, L., Massafra, M., Massi, M., Massignani, D. M., Matarese, A. M., Matini, G., Mauro, R., Mazzi, M., Mazzillo, A., Mazzocato, E., Mazzoleni, N. S., Mazzone, A., Melacci, A., Mele, E., Meliota, P., Menaspa, S., Meneghello, F., Merola, G., Merone, L., Metrucci, A., Mezzina, V., Micchi, A., Michielon, A., Migliore, N., Minero, G., Minotta, F., Mirandola, C., Mistrorigo, S., Modafferi, L., Moitre, R., Mola, E., Monachese, C., Mongiardini, C., Montagna, F., Montani, M., Montemurno, I., Montolli, R., Montorsi, S., Montresor, M., Monzani, M. G., Morabito, F., Mori, G., Moro, A., Mosca, M. F., Motti, F., Muddolon, L., Mugnai, M., Muscas, F., Naimoli, F., Nanci, G., Nargi, E., Nasorri, R., Nastrini, G., Negossi, M., Negrini, A., Negroni, A., Neola, V., Niccolini, F., Niro, C. M., Nosengo, C., Novella, G., Nuti, C., Obici, F., Olita, C., Oliverio, S. S., Olivieri, I., Oriente, S., Orlando, G., Paci, C., Pagano, G., Pagliara, C., Paita, G., Paladini, G., Paladino, G., Palano, T., Palatella, A., Palermo, P., Palmisano, M., Pando, P., Panessa, P., Panigo, F., Panozzo, G., Panvini, F., Panzieri, F., Panzino, A., Panzitta, F., Paoli, N., Papagna, R., Papaleo, M. G., Papalia, G., Parisi, R., Parotti, N., Parravicini, D., Passarella, P., Pastore, G. A., Patafio, M., Pavone, P., Pedroli, W., Pedroni, M., Pelligra, G., Pellizzari, M., Penati, A., Perlot, M., Perrone, A., Perrone, G., Peruzzi, P., Peselli, C., Petracchini, L., Petrera, L., Petrone, S., Peverelli, C., Pianorsi, F., Piazza, G. P., Piazzolla, G., Picci, A., Pienabarca, G., Pietronigro, T. P., Pignocchino, P., Pilone, R., Pinto, D., Pirovano, E., Pirrotta, D., Pisante, V., Pitotto, P., Pittari, L., Piva, A., Pizzoglio, A., Plantera, O. R., Plebani, W., Plessi, S., Podrecca, D., Poerio, V., Poggiani, F., Pogliani, W., Poli, L., Poloni, F. G., Porcelli, R., Porto, S., Pranzo, L., Prevedello, C., Profeta, C., Profico, D., Punzi, A., Quaglia, G. M., Racano, M., Raccone, A., Radice, F., Raho, C. A., Raimondi, R., Raino, M., Ramponi, R., Ramunni, A., Ramunni, A. L., Ravasio, F., Ravera, M., Re Sarto, G., Rebustello, G., Regazzoli, S., Restelli, C., Rezzonico, M., Ricchiuto, F., Rigo, S., Rigon, G., Rigon, R., Rinaldi, O. V., Rinaldi, M., Risplendente, P. G., Rispoli, M., Riundi, R., Riva, M. G., Rizzi, A. L., Rizzi, D., Rizzo, L. D., Rocchi, L., Rondinone, B., Rosa, B., Rosati, F., Roselli, F., Rossetti, A., Rossetti, C., Rossi, R., Rossi, P. R., Rossi, A., Rossi, C. L., Rossitto, A., Ruffini, R., Ruffo, A., Ruggio, S., Ruo, M., Russo, B., Russo, L., Russo, R., Russo, S., Russo, U., Russo, V., Ruta, G., Sacchi, F., Sacco Botto, F., Saia, A., Salladini, G., Salmoiraghi, S., Saluzzo, F., Salvatore, C., Salvatori, E., Salvio, G., Sandri, P., Sandrini, T., Sangermano, V., Santoni, N., Saracino, A. D., Saracino, A., Sarasin, P., Sardo Infirri, C., Sarri, B., Sartori, G., Sartori, N., Sauro, C., Scaglioni, M., Scalfi, C., Scamardella, A. M., Scandale, G., Scandone, L., Scannavini, G., Scarati, R., Scardi, A., Scarpa, F. M., Scazzi, P., Schifone, A., Schiroso, G., Scigliano, G., Scilla, A., Sciortino, M., Scolaro, G., Scollo, E., Scorretti, G., Sellitti, R., Selmo, A., Selvaggio, G., Sempio, A., Seren, F., Serio, L., Serra, C., Serra, L., Siciliano, D., Sideri, A., Sighele, M., Signore, R., Siliberto, F., Silvestro, M., Simioni, G., Simmini, G., Simonato, L., Sinchetto, F., Sizzano, E., Smajato, G., Smaldone, M., Sola, G., Sordillo, L., Sovran, C. S., Spagnul, P., Spano, F., Sproviero, S., Squintani, A., Stella, L., Stilo, V., Stocchiero, B., Stornello, M. C., Stracka, G., Strada, S., Stranieri, G., Stucci, N., Stufano, N., Suppa, A., Susca, V. G., Sutti, M., Taddei, M., Tagliabue, E., Tagliente, G., Talato, F., Talerico, P., Talia, R., Taranto, R., Tartaglia, M., Tauro, N., Tedesco, A., Tieri, P., Tirelli, M., Tocci, L., Todesco, P., Tognolo, M., Tomba, A., Tonello, P., Tonon, R., Toscano, L., Tosi, A., Tosi, G., Toso, S., Travaglio, P., Tremul, L., Tresso, C., Triacchini, P., Triggiano, L., Trigilio, A., Trimeloni, J., Tripicchio, G., Tritto, G. S., Trono, F., Trotta, E., Trotta, G., Tubertini, A., Turri, C., Turri, L., Tuttolani, M. P., Urago, M., Ursini, G., Valcanover, F., Valente, L., Valenti, M., Valentini, F., Vallone, G., Valz, P., Valzano, L., Vanin, V., Vatteroni, M., Vegetti, L., Vendrame, D., Veramonti, I., Veronelli, G., Vesco, A., Vicariotto, G., Vignale, G., Villa, P. L., Vinciguerra, R., Visco, A., Visentin, G., Visona, E., Vitali, E., Vitali, S., Vitti, F., Volpone, D. A., Zambon, N., Zammarrelli, A., Zanaboni, A., Zane, D., Zanetti, B., Zanibellato, R., Zappetti, M., Zappone, P., Zerilli, G., Zirino, V., Zoccali, R., Zuin, F., Altomonte, M., Anelli, N., Angio, F., Annale, P., Antonacci, S., Anzilotta, R., Bano, F., Basadonna, O., Beduschi, L., Becagli, P., Bellotti, G., Blotta, C., Bruno, G., Cappuccini, A., Caramatti, S., Cariolato, M. P., Castellana, M., Castellani, L., Catania, R., Chielli, A., Chinellato, A., Ciaccia, A., Clerici, E., Cocci, A., Costanzo, G., D'Ercole, F., De Stefano, G., Dece, F., Di Cicco, N., Di Marco, A., Donati Sarti, C., Draghi, E., Dusi, G., Esposito, V., Ferraro, L., Ferretti, A., Ferri, E., Foggetti, L., Foglia, A., Fonzi, E., Frau, G., Fuoco, M. R., Furci, G., Gallo, L., Garra, V., Giannini, A., Gris, A., Iacovino, R., Interrigi, R., Joppi, R., Laner, B., La Fortezza, G., La Padula, A., Lista, M. R., Lupi, G., Maffei, D., Maggioni, G., Magnani, L., Marrazzo, E., Marcon, L., Marino, V., Maroni, A., Martinelli, C., Mastandrea, E., Mastropierro, F., Meo, A. T., Mero, P., Minesso, E., Moschetta, V., Mosele, E., Nanni, C., Negretti, A., Nistico, C., Orsini, A., Osti, M., Pacilli, M. C., Pennestre, C., Picerno, G., Piol, K., Pivano, L., Pizzuti, E., Poggi, L., Poidomani, I., Pozzetto, M., Presti, M. L., Ravani, R., Recalenda, V., Romagnuolo, F., Rossignoli, S., Rossin, E., Sabatella, C., Sacco, F., Sanita, F., Sansone, E., Servadei, F., Sisto, M. T., Sorio, A., Sorrentino, A., Spinelli, E., Spolaor, A., Squillacioti, A., Stella, P., Talerico, A., Todisco, C., Vadino, M., and Zuliani, C.
- Subjects
Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Population ,030209 endocrinology & metabolism ,030204 cardiovascular system & hematology ,Overweight ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Prediction model ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,Diabetes Mellitus ,Medicine ,Humans ,Multicenter Studies as Topic ,Myocardial infarction ,Risk factor ,education ,Stroke ,Aged ,Randomized Controlled Trials as Topic ,education.field_of_study ,Lifestyle habits ,business.industry ,Major cardiovascular events ,Atrial fibrillation ,General Medicine ,Middle Aged ,medicine.disease ,Cardiovascular Diseases ,Heart failure ,Physical therapy ,Female ,medicine.symptom ,business ,Diabetic Angiopathies - Abstract
To verify whether it is possible, in people with diabetes mellitus (DM) considered at very high cardiovascular (CV) risk, stratify this risk better and identify significant modifiable risk factor (including lifestyle habits) to help patients and clinicians improve CV prevention. People with DM and microvascular diseases or one or more CV risk factors (hypertension, hyperlipidemia, smoking, poor dietary habits, overweight, physical inactivity) included in the Risk and Prevention study were selected. We considered the combined endpoint of non-fatal acute myocardial infarction and stroke and CV death. A multivariate Cox proportional analysis was carried out to identify relevant predictors. We also used the RECPAM method to identify subgroups of patients at higher risk. In our study, the rate of major CV events was lower than expected (5 % in 5 years). Predictors of CV events were age, male, sex, heart failure, previous atherosclerotic disease, atrial fibrillation, insulin treatment, high HbA1c, heart rate and other CV diseases while being physically active was protective. RECPAM analysis indicated that history of atherosclerotic diseases and a low BMI defined worse prognosis (HR 4.51 95 % CI 3.04–6.69). Among subjects with no previous atherosclerotic disease, men with HbA1c more than 8 % were at higher CV risk (HR 2.77; 95 % CI 1.86–4.14) with respect to women. In this population, the rate of major CV events was lower than expected. This prediction model could help clinicians identify people with DM at higher CV risk and support them in achieving goals of physical activity and HbA1c.
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- 2016
28. Regular Wine Consumption in Chronic Heart Failure: Impact on Outcomes, Quality of Life, and Circulating Biomarkers
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Cosmi, Franco, Di Giulio, Paola, Masson, Serge, Finzi, Andrea, Marfisi, Rosa Maria, Cosmi, Deborah, Scarano, Marco, Tognoni, Gianni, Maggioni, Aldo P., Porcu, Maurizio, Boni, Silvana, Cutrupi, Giovanni, Tavazzi, Luigi, Latini, Roberto Tavazzi, L, Tognoni, G, Barlera, S, Franzosi, Mg, Latini, R, Lucci, D, Maggioni, Ap, Marchioli, R, Nicolosi, Gl, Porcu, M, Yusuf, S, Camerini, F, Cohn, Jn, Decarli, A, Pitt, B, Sleight, P, Poole-Wilson, Pa, Geraci, E, Scherillo, M, Fabbri, G, Bartolomei, B, Bertoli, D, Cobelli, F, Fresco, C, Ledda, A, Levantesi, G, Opasich, C, Rusconi, F, Sinagra, G, Turazza, F, Volpi, A, Ceseri, M, Alongi, G, Atzori, A, Bambi, F, Bastarolo, D, Bianchini, F, Cangioli, I, Canu, V, Caporusso, C, Cenni, G, Cintelli, L, Cocchio, M, Confente, A, Fenicia, E, Friso, G, Gianfriddo, M, Grilli, G, Lazzaro, B, Lonardo, G, Luise, A, Nota, R, Orlando, M, Petrolo, R, Pierattini, C, Pierota, V, Provenzani, A, Quartuccio, V, Ragno, A, Serio, C, Spolaor, A, Tafi, A, Tellaroli, E, Ghio, S, Ghizzardi, E, Masson, S, Crociati, L, Rovere, Mt, Corra, U, Di Giulio, P, Finzi, A, Gorini, M, Gonzini, L, Milani, V, Orsini, G, Bianchini, E, Cabiddu, S, Cipressa, L, Cipressa, Ml, Di Bitetto, G, Ferri, B, Galbiati, L, Lorimer, A, Pera, C, Priami, P, Rossi, Mg, Pasotti, E, Vaghi, F, Roncarolo, P, Zunino, Mt, Matta, F, Actis, E, Gaita, F, Azzaro, G, Zanetta, M, Paino, Am, Parravicini, U, Vegis, D, Conte, R, Ferraro, P, De Bernardi, A, Morelloni, S, Fagnani, M, Lucchina, Pg, Montagna, L, Bellone, E, Sappe, D, Ferraro, F, Delucchi, M, Reynaud, Sg, Dore, M, La, A, Massobrio, N, Bo, L, Trinchero, R, Imazio, M, Brocchi, G, Nejrotti, A, Rissone, L, Gabasio, S, Zocchi, C, Randazzo, S, Crenna, A, Giannuzzi, P, Bonanomi, E, Mezzani, A, De Marchi, M, Begliuomini, G, Gianonatti, Ca, Gavazzi, A, Grosu, A, Cas, Ld, Nodari, S, Garyfallidis, P, Bertoletti, A, Bonifazi, C, Arisi, S, Mascaro, F, Fraccarollo, M, Dell, S, Sfolcini, M, Bortolini, F, Raccagni, D, Turelli, A, Santarone, M, Miglierina, E, Sormani, L, Jemoli, R, Tettamanti, F, Pirelli, S, Bianchi, C, Verde, S, Mariani, M, Ziacchi, V, Ferrazza, A, Russo, A, Bortolotti, M, Pasini, Gf, Jones, Kn, Cuzzucrea, D, Gullace, G, Carbone, C, Granata, A, De, S, Del Rosso, G, Inserra, C, Renaldini, E, Zappa, C, Moretti, M, Zanini, R, Ferrari, M, Cei, A, Lissi, C, Dovico, E, Fiorentini, C, Palermo, P, Brusoni, B, Negrini, M, Heyman, J, Danzi, Gb, Frigerio, M, Beretta, L, Sachero, A, Casazza, F, Squadroni, L, Lombardi, F, Marano, L, Margonato, A, Fragasso, G, Febo, Oc, Aiolfi, E, Olmetti, F, Grieco, A, Antonazzo, V, Specchia, G, Mortara, A, Robustelli, F, Songini, Mg, Schweiger, C, Frisinghelli, A, Palvarini, M, Campana, C, Scelsi, L, Marsan, Na, Gualco, A, De Feo, S, Iannone, Ma, Diaco, T, Zaniboni, D, Milanesi, G, Nassiacos, D, Meloni, S, Giani, P, Nicoli, T, Malinverni, C, Gusmini, A, Pozzoni, L, Bisiani, G, Margaroli, P, Schizzarotto, A, Daverio, A, Morelli, E, Occhi, G, Partesana, N, Bandini, P, Rosella, Mg, Giustiniani, S, Cucchi, G, Pedretti, R, Raimondo, R, Vaninetti, R, Fedele, A, Ghezzi, I, Rezzonico, E, Salerno, Ja, Morandi, F, Salvucci, F, Valenti, C, Graziano, G, Romano, M, Cimminiello, C, Mangone, I, Lombardo, M, Quorso, P, Marinoni, G, Breghi, M, Erckert, M, Dienstl, A, Mirante, G, Stefenelli, C, Cioffi, G, Buczkowska, E, Bonanome, A, Bazzanini, F, Parissenti, L, Serafini, C, Catania, G, Tarantini, L, Rigatelli, G, Boni, S, Pasini, A, Masini, E, Zampiero, Aa, Zanchetta, M, Franceschetto, L, Delise, P, Marcon, C, Sacchetta, A, Borgese, L, Artusi, L, Casolino, P, Corbara, F, Banzato, A, Barbiero, M, Aldegheri, Mp, Bazzucco, R, Crivellenti, G, Raviele, A, Zanella, C, Pascotto, P, Sarto, P, Milan, S, Barbieri, E, Girardi, P, Dalla, W, Mule, Jd, Di Sipio ML, Cazzin, R, Milan, D, Zonzin, P, Carraro, M, Rossi, R, Carbonieri, E, Rossi, I, Stritoni, P, Meneghetti, P, Risica, G, Tenderini, Pl, Vassanelli, C, Zanolla, L, Perini, G, Brighetti, G, Chiozza, R, Giuliano, G, Baldin, Mg, Gortan, R, Cesanelli, R, Piazza, R, Mos, L, Vriz, O, Pavan, D, Pascottini, G, Alberti, E, Werren, M, Solinas, L, Longaro, F, Fioretti, P, Albanese, Mc, Miani, D, Gianrossi, R, Pende, A, Rubartelli, P, Magaia, O, Caruso, D, Faraguti, As, Magliani, L, Miccoli, F, Guglielmino, G, Cantarelli, A, Orlandi, S, Vallebona, A, Pozzati, A, Brega, G, Pancaldi, Lg, Vandelli, R, Urbinati, S, Poci, Mg, Zoli, M, Costa, Gm, Guiducci, U, Zobbi, G, Tartagni, F, Tisselli, A, Gentili, A, Pieri, P, Cagnetta, E, Bendinelli, S, Barbieri, A, Conti, R, Ferrari, R, Merlini, F, Fucili, A, Moruzzi, P, Buia, E, Galvani, M, Ferrini, D, Baggioni, G, Yiannacopulu, P, Canè, G, Bonfiglioli, A, Zandomeneghi, R, Brugioni, L, Giannini, A, Di, R, Giuliani, M, Rusconi, L, Del Corso, P, Piovaccari, G, Bologna, F, Venturi, P, Melandri, F, Bagni, E, Bolognese, L, Perticucci, R, Zuppiroli, A, Nannini, M, Consoli, N, Petrone, P, Pipitò, C, Colombi, L, Bernardi, D, Mariani, Pr, Testa, R, Mazzinghi, F, Cosmi, F, Cosmi, D, Zipoli, A, Cecchi, A, Castelli, G, Ciaccheri, M, Mori, F, Pieri, F, Valoti, P, Chiarantini, D, Santoro, Gm, Minneci, C, Marchi, F, Milli, M, Zambaldi, G, Geri, Aa, Cipriani, M, Alessandri, M, Severi, S, Stefanelli, S, Comella, A, Poddighe, R, Digiorgio, A, Carluccio, M, Berti, S, Rizza, A, Bonatti, V, Molendi, V, Brancato, A, D'Aprile, N, Giappichini, G, Del Vecchio, S, Mantini, G, De Tommasi, F, Meucci, G, Cordoni, M, Bechi, S, Barsotti, L, Baldini, P, Romei, M, Scopelliti, G, Lauri, G, Pestelli, F, Furiozzi, F, Cocchieri, M, Severini, D, Patriarchi, F, Chiocchi, P, Buccolieri, M, Martinelli, S, Wee, A, Angelici, F, Bernardinangeli, M, Proietti, G, Biscottini, B, Panciarola, R, Marinacci, L, Perna, Gp, Gabrielli, D, Moraca, A, Moretti, L, Partemi, L, Gregori, G, Amici, R, Patteri, G, Capone, P, Savini, E, Morgagni, Gl, Paccaloni, L, Pezzuoli, F, Carincola, S, Papi, S, De Crescentini, S, Gerardi, P, Midi, P, Gallenzi, E, Pajes, G, Mancone, C, Di, V, Di Gennaro, M, Calcagno, S, Toscano, S, Antonicoli, S, Carta, F, Giorgi, G, Comito, F, Daniele, E, Goretti, Sm, Ciarla, O, Gelfo, Pg, Acquaviva, A, Testa, D, Testa, G, Pagliaro, Fa, Russo, F, Vetta, F, Marchese, I, Di, G, D'Ambrosio, A, Leggio, F, Del Sindaco, D, Lacchè, A, Avallone, A, Risa, Mp, Azzolini, P, Baldo, E, Giovannini, E, Pulignano, G, Tondo, C, Picchio, E, Biffani, E, Tanzi, P, Pozzar, F, Farnetti, F, Azzarito, M, Santini, M, Varveri, A, Ferraiuolo, G, Valtorta, C, Gaspardone, A, Barbato, G, Ceci, V, Aspromonte, N, Bellocci, F, Colizzi, C, Fedele, F, Perez, Fi, Galati, A, Rossetti, A, Mainella, A, Ciuffetta, D, Matteucci, C, Busi, G, De, A, Farina, G, Granatelli, A, Leone, F, Frasca, F, Castellani, G, Massaro, G, Mastrogiuseppe, G, Vacri, A, De Sanctis, F, Cioli, M, Di Luzio, S, Napoletano, C, Piccioni, Ll, De Simone, G, Ottaviano, A, Mazza, V, Spedaliere, C, Staniscia, Td, Calgione, E, De Marco, G, Chiacchio, T, Di, T, Romanzi, S, Salvatore, G, Golino, P, Palermo, A, Mascia, F, Vetrano, A, Vinciguerra, A, Caliendo, L, Longobardi, R, De Caro, G, Di Nola, R, Piemonte, F, Prinzi, D, De Rosa, P, De, V, Riello, F, Capuano, V, Vecchio, G, Landi, M, Amato, S, Garofalo, M, D'Avino, M, Sensale, P, Maiolica, O, Santoro, R, Caso, P, Miceli, D, Maurea, N, Bianchi, U, Crispo, C, Chiariello, M, Filardi, Pp, Russo, L, Capuano, N, Ungaro, G, Vergara, G, Scafuro, F, D'Angelo, G, Campaniello, C, Bottiglieri, P, Volpe, A, Battista, R, De Risi, L, Cardillo, G, Sibilio, G, Marino, Ap, Silvestri, F, Predotti, P, Iervoglini, A, De Matteis, C, Sarnicola, P, Matarazzo, Mm, Baldi, S, Iuliano, V, Astarita, C, Cuccaro, P, Liguori, A, Liguori, G, Gregorio, G, Petraglia, L, Antonelli, G, Amodio, G, De Luca, I, Franchini, G, Lenti, Ml, Cavallari, D, D'Agostino, C, Scalera, G, Altamura, Cm, Russo, M, Mascolo, Ar, Pettinati, G, Ciricugno, Sa, Scrutinio, D, Passantino, A, Mastrangelo, D, Di Masi, A, De, R, Cannone, M, Dibiase, F, Pensato, M, Loliva, F, Trapani, F, Panettieri, I, Leone, L, Di, M, Carrone, M, Gallone, V, Cocco, F, Costantini, M, Tritto, C, Cavalieri, F, Stella, L, Magliari, F, Callerame, M, De Giorgi, A, Pellegrino, L, Correra, M, Portulano, V, Nisi, Gl, Grassi, G, Cristallo, E, De Laura, D, Salerno, C, Fanelli, R, Villella, M, Pede, S, Renna, A, De Lorenzi, E, Urso, L, Lenti, V, Peluso, A, Baldi, N, Polimeni, G, Palma, P, Lauletta, R, Tagliamonte, E, Cirillo, T, Centonze, G, D'Alessandro, B, Truncellito, L, Mecca, D, Petruzzi, Ma, Coviello, Ro, Lopizzo, A, Chiaffitelli, M, Barbuzzi, S, Gubelli, S, Germinario, G, Cosentino, N, Mingrone, A, Vico, R, Borrello, G, Mazza, Ml, Cimino, R, Galasso, D, Cassadonte, F, Talarico, U, Perticone, F, Cassano, S, Catapano, F, Calemme, S, Feraco, E, Cloro, C, Misuraca, G, Caporale, R, Vigna, L, Spagnuolo, V, De Rosa, F, Spadafora, G, Zampaglione, G, Russo, R, Schipani, Fa, Ferragina, Af, Stranieri, D, Musca, G, Carpino, C, Bencardino, P, Raimondo, F, Musacchio, D, Pulitano, G, Ruggeri, A, Provenzano, A, Salituri, S, Musolino, M, Calandruccio, S, Marrari, A, Tripodi, E, Scali, R, Anastasio, L, Arone, A, Aragona, P, Donnangelo, L, Comito, Mg, Bilotta, F, Vaccaro, I, Rametta, R, Ventura, V, Bonvegna, A, Alì, A, Cinnirella, C, Raineri, M, Pompeo, F, Ingurgio, Nc, Carini, V, Coco, R, Giunta, G, Leonardi, G, Randazzo, V, Di Blasi, V, Tamburino, C, Russo, G, Mangiameli, S, Cardillo, R, Castelli, D, Inserra, V, Arena, A, Gulizia, Mm, Raciti, S, Rapisarda, G, Romano, R, Prestifilippo, P, Braschi, Gb, Ledda, G, Terrazzino, R, De Caro, M, Scilabra, G, Graffagnino, B, Grassi, R, Scimone, Gf, Vasquez, L, Coppolino, C, Casale, A, Castelli, M, D'Urso, G, D'Antonio, E, Presti, Ll, Badalamenti, E, Conti, P, Sanfilippo, N, Cirrincione, V, Cinà, Mt, Cusimano, G, Taormina, A, Giuliano, P, Bajardi, A, Mandala, V, Canonico, A, Geraci, G, Sabella, Fp, Enia, F, Floresta, Am, Cascio, Il, Gumina, D, Cavallaro, A, Piccione, G, Ferrante, R, Blandino, M, Iudicello, Ms, Mossuti, E, Romano, G, Lombardo, L, Monastra, P, Di Vincenzo, D, Orru, P, Muscas, F, Giardina, G, Corda, M, Locci, G, Podda, A, Ledda, M, Siddi, P, Lai, C, Pili, G, Mercuro, G, Mureddu, G, Ganau, A, Meloni, G, Poddighe, G, Sanna, G., Cosmi, Franco, Di Giulio, Paola, Masson, Serge, Finzi, Andrea, Marfisi, Rosa Maria, Cosmi, Deborah, Scarano, Marco, Tognoni, Gianni, Maggioni, Aldo P, Porcu, Maurizio, Boni, Silvana, Cutrupi, Giovanni, Tavazzi, Luigi, Latini, Roberto, on behalf of the GISSI-HF, Investigator, Margonato, Alberto, DI GIULIO, Paola, Maggioni, Aldo P., GISSI HF, Investigator, and Sinagra, Gianfranco
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Male ,Health Status ,Left ,Wine ,Comorbidity ,Ventricular Function, Left ,Health Statu ,Quality of life ,Risk Factors ,Surveys and Questionnaires ,Prevalence ,Ventricular Function ,Surveys and Questionnaire ,Depression (differential diagnoses) ,Depression ,Medicine (all) ,Middle Aged ,Prognosis ,biological marker ,Italy ,Female ,Risk assessment ,Cardiology and Cardiovascular Medicine ,biological markers ,Human ,Cardiac function curve ,Vasculitis ,medicine.medical_specialty ,Vasculiti ,Alcohol Drinking ,Prognosi ,Lower risk ,Risk Assessment ,Internal medicine ,medicine ,Humans ,Protective Factor ,Aged ,Heart Failure ,business.industry ,Risk Factor ,Stroke Volume ,Biomarker ,quality of life ,wine ,aged ,alcohol drinking ,biomarkers ,chronic disease ,comorbidity ,depression ,female ,heart failure ,humans ,italy ,male ,middle aged ,prevalence ,prognosis ,protective factors ,risk assessment ,risk factors ,stroke volume ,surveys and questionnaires ,vasculitis ,ventricular function, left ,health status ,cardiology and cardiovascular medicine ,Biomarkers ,Chronic Disease ,Protective Factors ,Quality of Life ,medicine.disease ,Clinical trial ,Heart failure ,Physical therapy ,business - Abstract
Background— Moderate, regular alcohol consumption is generally associated with a lower risk of cardiovascular events but data in patients with chronic heart failure are scarce. We evaluated the relations between wine consumption, health status, circulating biomarkers, and clinical outcomes in a large Italian population of patients with chronic heart failure enrolled in a multicenter clinical trial. Methods and Results— A brief questionnaire on dietary habits was administered at baseline to 6973 patients enrolled in the Gruppo Italiano per lo Studio della Sopravvivenza nell’Insufficienza Cardiaca-Heart Failure (GISSI-HF) trial. The relations between wine consumption, fatal and nonfatal clinical end points, quality of life, symptoms of depression, and circulating biomarkers of cardiac function and inflammation (in subsets of patients) were evaluated with simple and multivariable-adjusted statistical models. Almost 56% of the patients reported drinking at least 1 glass of wine per day. After adjustment, clinical outcomes were not significantly different in the predefined 4 groups of wine consumption. However, patients with more frequent wine consumption had a significantly better perception of health status (Kansas City Cardiomyopathy Questionnaire score, adjusted P P =0.01), and lower plasma levels of biomarkers of vascular inflammation (osteoprotegerin and C-terminal proendothelin-1, adjusted P P =0.01) after adjusting for possible confounders. Conclusions— We show for the first time in a large cohort of patients with chronic heart failure that moderate wine consumption is associated with a better perceived and objective health status, lower prevalence of depression, and less vascular inflammation, but does not translate into more favorable clinical 4-year outcomes. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT0033633.
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- 2015
29. Role of Three-Hour Postprandial Intraesophageal pH Monitoring in the Diagnosis of Gastroesophageal Reflux
- Author
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Grande, L., Pujol, A., Ros, E., Pera, C., Siewert, J. R., editor, and Hölscher, A. H., editor
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- 1988
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30. [Quality of life, depression and cognitive functions 1. Operational protocol and its implementation]
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Rete Infermieri GISSI HF, Di Giulio P, Pera C, Scarano M, Ferri B, Lepore V, Miani D, Tognoni G, Rosson V, Serafini C, Zumino T, Partemi L, Falleroni ML, Moretti L, Porta L, Santorsola A, Tenerelli T, Bertoncelli B, Mengoli G, Stagnitto M, Puddu GM, Masini E, Pasini A, Boni S, Valsesia E, Cornacini G, Melis D, Mulina A, Giurlanda A, Fava M, Bellini P, Vallucci S, Cuomo A, Campanale S, Monatti G, Bianco T, Milli V, Antonelli L, Fanin L, Faiola L, Stefanizzi R, Mariani M, Rossi A, Regnani T, Loreni F, Cianfrocca R, Pisani A, Faraolfi V, Ponzalli P, Savli T, Cresci M, Guardalben S, Belluzzo B, Ruberti R, Zizzi M, Tonda C, Cadrobbi MG, Gilardi R, Mondì A, Costa A, Milan S, Zottarelli A, Parodi B, Sartorio N, Rossin B, Santi A, Cagnan P, Maradei E, Cauteruccio A, Carpino C, Addeo R, Izzo A, Amendola G, Prizzitano AM, Piluso GM, Iadevaio AL, Cinà MT, Cirrincione V, Gumina S, Codato G, Raimondo F, Capiello MG, Creta F, Barbieri M, Chiarella L, Abbondio L, Piccin M, Spillone V, Cutrupi G, Ruggeri A, Sicilia G, Provengano A, Marcari P, Ricci S, Pazzagli E, La Grotteria M, Orsini R, Leandri L, Vetere NA, Braggion E, Giordanino S, Armando S, Zampieri E, Danese MC, Valentini A, Ferrante MG, Santacroce C, Crocetti I, Macchi F, Bernacchi M, Pini D, Varì M, Lucente M, Scaramastra F, Reichardt S, Gabasio S, Zocchi C, Studhika M, Budzowska E, Cescon M, Lazzari D, Prizzon A, Di Biaggio P, Buda C, Mastrangelo V, Avigliano M, Dell'Aquila L, Bonanomi E, Mezzani A, Porcini F, Girardi G., PERRONE FILARDI, PASQUALE, Rete Infermieri GISSI, Hf, Di Giulio, P, Pera, C, Scarano, M, Ferri, B, Lepore, V, Miani, D, Tognoni, G, Rosson, V, Serafini, C, Zumino, T, Partemi, L, Falleroni, Ml, Moretti, L, Porta, L, Santorsola, A, Tenerelli, T, Bertoncelli, B, Mengoli, G, Stagnitto, M, Puddu, Gm, Masini, E, Pasini, A, Boni, S, Valsesia, E, Cornacini, G, Melis, D, Mulina, A, Giurlanda, A, Fava, M, Bellini, P, Vallucci, S, Cuomo, A, Campanale, S, Monatti, G, Bianco, T, Milli, V, Antonelli, L, Fanin, L, Faiola, L, Stefanizzi, R, Mariani, M, Rossi, A, Regnani, T, Loreni, F, Cianfrocca, R, Pisani, A, Faraolfi, V, Ponzalli, P, Savli, T, Cresci, M, Guardalben, S, Belluzzo, B, Ruberti, R, Zizzi, M, Tonda, C, Cadrobbi, Mg, Gilardi, R, Mondì, A, Costa, A, Milan, S, Zottarelli, A, Parodi, B, Sartorio, N, Rossin, B, Santi, A, Cagnan, P, Maradei, E, Cauteruccio, A, Carpino, C, Addeo, R, Izzo, A, Amendola, G, PERRONE FILARDI, Pasquale, Prizzitano, Am, Piluso, Gm, Iadevaio, Al, Cinà, Mt, Cirrincione, V, Gumina, S, Codato, G, Raimondo, F, Capiello, Mg, Creta, F, Barbieri, M, Chiarella, L, Abbondio, L, Piccin, M, Spillone, V, Cutrupi, G, Ruggeri, A, Sicilia, G, Provengano, A, Marcari, P, Ricci, S, Pazzagli, E, La Grotteria, M, Orsini, R, Leandri, L, Vetere, Na, Braggion, E, Giordanino, S, Armando, S, Zampieri, E, Danese, Mc, Valentini, A, Ferrante, Mg, Santacroce, C, Crocetti, I, Macchi, F, Bernacchi, M, Pini, D, Varì, M, Lucente, M, Scaramastra, F, Reichardt, S, Gabasio, S, Zocchi, C, Studhika, M, Budzowska, E, Cescon, M, Lazzari, D, Prizzon, A, Di Biaggio, P, Buda, C, Mastrangelo, V, Avigliano, M, Dell'Aquila, L, Bonanomi, E, Mezzani, A, Porcini, F, and Girardi, G.
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Time Factors ,Depression ,Cardiology ,Prognosis ,Nursing Research ,Cognition ,Clinical Protocols ,Italy ,Data Interpretation, Statistical ,Surveys and Questionnaires ,Quality of Life ,Humans ,Cardiomyopathies ,Geriatric Assessment ,Aged ,Randomized Controlled Trials as Topic - Abstract
The QDF (Quality of life, Depression and cognitive Function) is a project elaborated and implemented by a Research Network of the nursing personnel of the cardiological services which promoted and run the GISSI-HF trial. It is a "companion study" which included up to 1/3 of all the GISSI-HF centres.To describe the distribution and evaluation of QDF variables measured with standardised instruments (Kansas City Cardiomiopathy Quality of Life questionnaire, KCCQ; Geriaric Depression scale GDS, Mini Mental State Examination MMSE), to verify whether and how far their knowledge could influence clinical decisions; to assess the prognostic impact of QDF values measured at entrance on mortality and morbidity. The study protocol included also a comprehensive evaluation of QDF variables independent from the questionnaires, by the nurses in charge of the study patients (the results of this part of the protocol are not included in this report).The QDF data were collected at baseline, 6 months, 1, 2 and 3 years through two self administered questionnaires (KCCQ, GDS), while the MMSE only for patients70 years. The questionnaires were administered to the patients who accepted to participate. A specific goal of the project focuses on the degree of independence between the results of the questionnaires and the judgement of the nurses. This contribution presents the operational implementation of the study protocol and general framework.
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- 2009
31. [Quality of life, depression and cognitive functions 2. Methodological aspects and data quality]
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Rete Infermieri GISSI HF, Di Giulio P, Pera C, Scarano M, Ferri B, Lepore V, Miani D, Tognoni G, Rosson V, Serafini C, Zumino MT, Partemi L, Falleroni ML, Moretti L, Porta L, Santorsola A, Tenerelli T, Bertoncelli B, Mengoli G, Stagnitto M, Puddu GM, Masini E, Pasini A, Boni S, Valsesia E, Cornacini G, Melis D, Mulina A, Giurlanda A, Fava M, Bellini P, Vallucci S, Cuomo A, Campanale S, Monatti G, Bianco T, Milli V, Antonelli L, Fanin L, Faiola L, Stefanizzi R, Mariani M, Rossi A, Regnani ST, Loreni F, Cianfrocca R, Pisani A, Faraolfi V, Ponzalli P, Savli T, Cresci M, Guardalben S, Belluzzo B, Ruberti R, Zizzi M, Tonda C, Cadrobbi MG, Gilardi R, Mondì A, Costa A, Milan S, Zottarelli A, Parodi B, Sartorio N, Rossin B, Santi A, Cagnan P, Maradei E, Cauteruccio A, Carpino C, Addeo R, Izzo A, Amendola G, Prizzitano AM, Piluso GM, Iadevaio AL, Cinà MT, Cirrincione V, Gumina S, Codato G, Raimondo F, Capiello MG, Creta F, Barbieri M, Chiarella L, Abbondio L, Piccin M, Spillone V, Cutrupi G, Ruggeri A, Sicilia G, Provengano A, Marcari P, Ricci S, Pazzagli E, La Grotteria M, Orsini R, Leandri L, Vetere NA, Braggion E, Giordanino S, Armando S, Zampieri E, Danese MC, Valentini A, Ferrante MG, Santacroce C, Crocetti I, Macchi F, Bernacchi M, Pini D, Varì M, Lucente M, Scaramastra F, Reichardt S, Gabasio S, Zocchi C, Studhika M, Budzowska E, Cescon M, Lazzari D, Prizzon A, Di Biaggio P, Buda C, Mastrangelo V, Avigliano M, Dell'Aquila L, Bonanomi E, Mezzani A, Porcini F, Girardi G., PERRONE FILARDI, PASQUALE, Rete Infermieri GISSI, Hf, Di Giulio, P, Pera, C, Scarano, M, Ferri, B, Lepore, V, Miani, D, Tognoni, G, Rosson, V, Serafini, C, Zumino, Mt, Partemi, L, Falleroni, Ml, Moretti, L, Porta, L, Santorsola, A, Tenerelli, T, Bertoncelli, B, Mengoli, G, Stagnitto, M, Puddu, Gm, Masini, E, Pasini, A, Boni, S, Valsesia, E, Cornacini, G, Melis, D, Mulina, A, Giurlanda, A, Fava, M, Bellini, P, Vallucci, S, Cuomo, A, Campanale, S, Monatti, G, Bianco, T, Milli, V, Antonelli, L, Fanin, L, Faiola, L, Stefanizzi, R, Mariani, M, Rossi, A, Regnani, St, Loreni, F, Cianfrocca, R, Pisani, A, Faraolfi, V, Ponzalli, P, Savli, T, Cresci, M, Guardalben, S, Belluzzo, B, Ruberti, R, Zizzi, M, Tonda, C, Cadrobbi, Mg, Gilardi, R, Mondì, A, Costa, A, Milan, S, Zottarelli, A, Parodi, B, Sartorio, N, Rossin, B, Santi, A, Cagnan, P, Maradei, E, Cauteruccio, A, Carpino, C, Addeo, R, Izzo, A, Amendola, G, PERRONE FILARDI, Pasquale, Prizzitano, Am, Piluso, Gm, Iadevaio, Al, Cinà, Mt, Cirrincione, V, Gumina, S, Codato, G, Raimondo, F, Capiello, Mg, Creta, F, Barbieri, M, Chiarella, L, Abbondio, L, Piccin, M, Spillone, V, Cutrupi, G, Ruggeri, A, Sicilia, G, Provengano, A, Marcari, P, Ricci, S, Pazzagli, E, La Grotteria, M, Orsini, R, Leandri, L, Vetere, Na, Braggion, E, Giordanino, S, Armando, S, Zampieri, E, Danese, Mc, Valentini, A, Ferrante, Mg, Santacroce, C, Crocetti, I, Macchi, F, Bernacchi, M, Pini, D, Varì, M, Lucente, M, Scaramastra, F, Reichardt, S, Gabasio, S, Zocchi, C, Studhika, M, Budzowska, E, Cescon, M, Lazzari, D, Prizzon, A, Di Biaggio, P, Buda, C, Mastrangelo, V, Avigliano, M, Dell'Aquila, L, Bonanomi, E, Mezzani, A, Porcini, F, and Girardi, G.
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Depression ,Patient Selection ,Cardiology ,Middle Aged ,Prognosis ,Nursing Research ,Cognition ,Italy ,Surveys and Questionnaires ,Quality of Life ,Humans ,Multicenter Studies as Topic ,Cardiomyopathies ,Geriatric Assessment ,Aged ,Randomized Controlled Trials as Topic - Abstract
To document the degree of reliability of validated and mainly qualitative questionnaires most often used in research settings and/or projects, in a broad network of unselected cardiological centres; to assess whether the quality of data could be compatible with their use not only as descriptive but also in prognostic scores including mainly "hard" clinical variables.Eighty-three patients were included. Compliance with the self-administration of the Kansas City Cardiomiopathy Questionnaire (KCCQ) and the Geriatric Depression Scale (GDS) was very high throughout the study (KCCQ 97.7% baseline and 85.8% at three years). As expected more difficulties were encountered with the Mini Mental State Examination (administered to 80.6% patients baseline and to 54.3% at three years). Main reasons for not administering questionnaires was ascribed to organizational and patients problems.It is worth noticing that the study was conducted by nurses without economical incentives. The questionnaires were well completed with minimal missing data. If questionnaires are well presented to patients, a routine assessment of quality of life and depression could be feasible in everyday care.
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- 2009
32. [Quality of life, depression and cognitive functions 4. Quality of life]
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Rete Infermieri GISSI HF, Di Giulio P, Pera C, Scarano M, Ferri B, Lepore V, Miani D, Tognoni G, Rosson V, Serafini C, Zumino MT, Partemi L, Falleroni ML, Moretti L, Porta L, Santorsola A, Tenerelli T, Bertoncelli B, Mengoli G, Stagnitto M, Puddu GM, Masini E, Pasini A, Boni S, Valsesia E, Cornacini G, Melis D, Mulina A, Giurlanda A, Fava M, Bellini P, Vallucci S, Cuomo A, Campanale S, Monatti G, Bianco T, Milli V, Antonelli L, Fanin L, Faiola L, Stefanizzi R, Mariani M, Rossi A, Regnani ST, Loreni F, Cianfrocca R, Pisani A, Faraolfi V, Ponzalli P, Savli T, Cresci M, Guardalben S, Belluzzo B, Ruberti R, Zizzi M, Tonda C, Cadrobbi MG, Gilardi R, Mondì A, Costa A, Milan S, Zottarelli A, Parodi B, Sartorio N, Rossin B, Santi A, Cagnan P, Maradei E, Cauteruccio A, Carpino C, Addeo R, Izzo A, Amendola G, Prizzitano AM, Piluso GM, Iadevaio AL, Cinà MT, Cirrincione V, Gumina S, Codato G, Raimondo F, Capiello MG, Creta F, Barbieri M, Chiarella L, Abbondio L, Piccin M, Spillone V, Cutrupi G, Ruggeri A, Sicilia G, Provengano A, Marcari P, Ricci S, Pazzagli E, La Grotteria M, Orsini R, Leandri L, Vetere NA, Braggion E, Giordanino S, Armando S, Zampieri E, Danese MC, Valentini A, Ferrante MG, Santacroce C, Crocetti I, Macchi F, Bernacchi M, Pini D, Varì M, Lucente M, Scaramastra F, Reichardt S, Gabasio S, Zocchi C, Studhika M, Budzowska E, Cescon M, Lazzari D, Prizzon A, Di Baggio P, Buda C, Mastrangelo V, Avigliano M, Dell'Aquila L, Bonanomi E, Mezzani A, Porcini F, Girardi G., PERRONE FILARDI, PASQUALE, Rete Infermieri GISSI, Hf, Di Giulio, P, Pera, C, Scarano, M, Ferri, B, Lepore, V, Miani, D, Tognoni, G, Rosson, V, Serafini, C, Zumino, Mt, Partemi, L, Falleroni, Ml, Moretti, L, Porta, L, Santorsola, A, Tenerelli, T, Bertoncelli, B, Mengoli, G, Stagnitto, M, Puddu, Gm, Masini, E, Pasini, A, Boni, S, Valsesia, E, Cornacini, G, Melis, D, Mulina, A, Giurlanda, A, Fava, M, Bellini, P, Vallucci, S, Cuomo, A, Campanale, S, Monatti, G, Bianco, T, Milli, V, Antonelli, L, Fanin, L, Faiola, L, Stefanizzi, R, Mariani, M, Rossi, A, Regnani, St, Loreni, F, Cianfrocca, R, Pisani, A, Faraolfi, V, Ponzalli, P, Savli, T, Cresci, M, Guardalben, S, Belluzzo, B, Ruberti, R, Zizzi, M, Tonda, C, Cadrobbi, Mg, Gilardi, R, Mondì, A, Costa, A, Milan, S, Zottarelli, A, Parodi, B, Sartorio, N, Rossin, B, Santi, A, Cagnan, P, Maradei, E, Cauteruccio, A, Carpino, C, Addeo, R, Izzo, A, Amendola, G, PERRONE FILARDI, Pasquale, Prizzitano, Am, Piluso, Gm, Iadevaio, Al, Cinà, Mt, Cirrincione, V, Gumina, S, Codato, G, Raimondo, F, Capiello, Mg, Creta, F, Barbieri, M, Chiarella, L, Abbondio, L, Piccin, M, Spillone, V, Cutrupi, G, Ruggeri, A, Sicilia, G, Provengano, A, Marcari, P, Ricci, S, Pazzagli, E, La Grotteria, M, Orsini, R, Leandri, L, Vetere, Na, Braggion, E, Giordanino, S, Armando, S, Zampieri, E, Danese, Mc, Valentini, A, Ferrante, Mg, Santacroce, C, Crocetti, I, Macchi, F, Bernacchi, M, Pini, D, Varì, M, Lucente, M, Scaramastra, F, Reichardt, S, Gabasio, S, Zocchi, C, Studhika, M, Budzowska, E, Cescon, M, Lazzari, D, Prizzon, A, Di Baggio, P, Buda, C, Mastrangelo, V, Avigliano, M, Dell'Aquila, L, Bonanomi, E, Mezzani, A, Porcini, F, and Girardi, G.
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Male ,Depression ,Cardiology ,Prognosis ,Hospitalization ,Nursing Research ,Cognition ,Italy ,Risk Factors ,Data Interpretation, Statistical ,Surveys and Questionnaires ,Quality of Life ,Humans ,Female ,Mortality ,Cardiomyopathies ,Aged ,Randomized Controlled Trials as Topic - Abstract
Aim of this paper is to explore and quanti-quantitatively assess whether QoL as measured with the Kansas City Cardiomiopathy Questionnaire (KCCQ) summary score could be considered as an independent relevant component of clinical prognostic score of morbidity and mortality and identify patients at risk for death or admissions.Sixty-three per cent NYHA II and 39.4% NYHA III-IV patients experience a good Qol (score75). Risk factors for "not good" (75) QoL are age, NYHA class III-IV, diabetes, COPD and previous hospitalizations. NYHA II and III-IV patients with not good QoL experience an higher mortality than patients with a good QoL in the same classes. NYHA II patients with not good QoL experience the same 1 year readmission rates as NYHA III-IV patients with good QoL.Quality of life scores identify patients with different risk of mortality and readmissions within the same NYHA class. The prognostic value of KCCQ summary scores could identify candidates for disease management in whom better targeted care strategies may reduce hospitalizations and prevent deaths.
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- 2009
33. [Quality of life, depression and cognitive functions 3. The main characteristics of the QDF study population]
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Rete Infermieri GISSI HF, Di Giulio P, Pera C, Scarano M, Ferri B, Lepore V, Miani D, Tognoni G, Rosson V, Serafini C, Zumino MT, Partemi L, Falleroni ML, Moretti L, Porta L, Santorsola A, Tenerelli T, Bertoncelli B, Mengoli G, Stagnitto M, Puddu GM, Masini E, Pasini A, Boni S, Valsesia E, Cornacini G, Melis D, Mulina A, Giurlanda A, Fava M, Bellini P, Vallucci S, Cuomo A, Campanale S, Monatti G, Bianco T, Milli V, Antonelli L, Fanin L, Faiola L, Stefanizzi R, Mariani M, Rossi A, Regnani ST, Loreni F, Cianfrocca R, Pisani A, Faraolfi V, Ponzalli P, Savli T, Cresci M, Guardalben S, Belluzzo B, Ruberti R, Zizzi M, Tonda C, Cadrobbi MG, Gilardi R, Mondì A, Costa A, Milan S, Zottarelli A, Parodi B, Sartorio N, Rossin B, Santi A, Cagnan P, Maradei E, Cauteruccio A, Carpino C, Addeo R, Izzo A, Amendola G, Prizzitano AM, Piluso GM, Iadevaio AL, Cinà MT, Cirrincione V, Gumina S, Codato G, Raimondo F, Cappiello MG, Creta F, Barbieri M, Chiarella L, Abbondio L, Piccin M, Spillone V, Cutrupi G, Ruggeri A, Sicilia G, Provengano A, Marcari P, Ricci S, Pazzagli E, La Grotteria M, Orsini R, Leandri L, Vetere NA, Braggion E, Giordanino S, Armando S, Zampieri E, Danese MC, Valentini A, Ferrante MG, Santacroce C, Crocetti I, Macchi F, Bernacchi M, Pini D, Varì M, Lucente M, Scaramastra F, Reichardt S, Gabasio S, Zocchi C, Studhika M, Budzowska E, Cescon M, Lazzari D, Prizzon A, Di Biaggio P, Buda C, Mastrangelo V, Avigliano M, Dell'Aquila L, Bonanomi E, Mezzani A, Porcini F, Girardi G., PERRONE FILARDI, PASQUALE, Rete Infermieri GISSI, Hf, Di Giulio, P, Pera, C, Scarano, M, Ferri, B, Lepore, V, Miani, D, Tognoni, G, Rosson, V, Serafini, C, Zumino, Mt, Partemi, L, Falleroni, Ml, Moretti, L, Porta, L, Santorsola, A, Tenerelli, T, Bertoncelli, B, Mengoli, G, Stagnitto, M, Puddu, Gm, Masini, E, Pasini, A, Boni, S, Valsesia, E, Cornacini, G, Melis, D, Mulina, A, Giurlanda, A, Fava, M, Bellini, P, Vallucci, S, Cuomo, A, Campanale, S, Monatti, G, Bianco, T, Milli, V, Antonelli, L, Fanin, L, Faiola, L, Stefanizzi, R, Mariani, M, Rossi, A, Regnani, St, Loreni, F, Cianfrocca, R, Pisani, A, Faraolfi, V, Ponzalli, P, Savli, T, Cresci, M, Guardalben, S, Belluzzo, B, Ruberti, R, Zizzi, M, Tonda, C, Cadrobbi, Mg, Gilardi, R, Mondì, A, Costa, A, Milan, S, Zottarelli, A, Parodi, B, Sartorio, N, Rossin, B, Santi, A, Cagnan, P, Maradei, E, Cauteruccio, A, Carpino, C, Addeo, R, Izzo, A, Amendola, G, PERRONE FILARDI, Pasquale, Prizzitano, Am, Piluso, Gm, Iadevaio, Al, Cinà, Mt, Cirrincione, V, Gumina, S, Codato, G, Raimondo, F, Cappiello, Mg, Creta, F, Barbieri, M, Chiarella, L, Abbondio, L, Piccin, M, Spillone, V, Cutrupi, G, Ruggeri, A, Sicilia, G, Provengano, A, Marcari, P, Ricci, S, Pazzagli, E, La Grotteria, M, Orsini, R, Leandri, L, Vetere, Na, Braggion, E, Giordanino, S, Armando, S, Zampieri, E, Danese, Mc, Valentini, A, Ferrante, Mg, Santacroce, C, Crocetti, I, Macchi, F, Bernacchi, M, Pini, D, Varì, M, Lucente, M, Scaramastra, F, Reichardt, S, Gabasio, S, Zocchi, C, Studhika, M, Budzowska, E, Cescon, M, Lazzari, D, Prizzon, A, Di Biaggio, P, Buda, C, Mastrangelo, V, Avigliano, M, Dell'Aquila, L, Bonanomi, E, Mezzani, A, Porcini, F, and Girardi, G.
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Aged, 80 and over ,Male ,Depression ,Age Factors ,Cardiology ,Prognosis ,Education ,Nursing Research ,Cognition ,Sex Factors ,Italy ,Surveys and Questionnaires ,Quality of Life ,Humans ,Female ,Cardiomyopathies ,Aged ,Randomized Controlled Trials as Topic - Abstract
This contribution describes the patients included for the QDF (Quality of life, Depression and Cognitive functions) study and explores the distribution and time trends of scores of the three dimensions.The large majority of patients are males (78.3%), and mean age is 67.2 +/- 10.7 years (9.2%80 years). Patients in NYHA class III-IV experience more depression and a worse QoL as compared to the less severly clinically affected counterparts in NYHA class. Although QoL and depression are influenced by the same variables, not all patients with bad QoL are depressed and viceversa. Mean scores of cognitive functioning are not influenced by the same variables that influence QoL and depression.The regular measurement of QoL, depression and cognitive function is recommended by some authors. It seems to be confirmed that the three dimensions need to be explored to disentangle the specific informative value that each of them could add to clinical measures.
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- 2009
34. [Quality of life, depression and cognitive functions 6. Cognitive functions]
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Rete Infermieri GISSI HF, Di Giulio P, Pera C, Scarano M, Ferri B, Lepore V, Miani D, Tognoni G, Rosson V, Serafini C, Zumino MT, Partemi L, Falleroni ML, Moretti L, Porta L, Santorsola A, Tenerelli T, Bertoncelli B, Mengoli G, Stagnitto M, Puddu GM, Masini E, Pasini A, Boni S, Valsesia E, Cornacini G, Melis D, Mulina A, Giurlanda A, Fava M, Bellini P, Vallucci S, Cuomo A, Campanale S, Monatti G, Bianco T, Milli V, Antonelli L, Fanin L, Faiola L, Stefanizzi R, Mariani M, Rossi A, Regnani ST, Loreni F, Cianfrocca R, Pisani A, Faraolfi V, Ponzalli P, Savli T, Cresci M, Guardalben S, Belluzzo B, Ruberti R, Zizzi M, Tonda C, Cadrobbi MG, Gilardi R, Mondì A, Costa A, Milan S, Zottarelli A, Parodi B, Sartorio N, Rossin B, Santi A, Cagnan P, Maradei E, Cauteruccio A, Carpino C, Addeo R, Izzo A, Amendola G, Prizzitano AM, Piluso GM, Iadevaio AL, Cinà MT, Cirrincione V, Gumina S, Codato G, Raimondo F, Cappiello MG, Creta F, Barbieri M, Chiarella L, Abbondio L, Piccin M, Spillone V, Cutrupi G, Ruggeri A, Sicilia G, Provengano A, Marcari P, Ricci S, Pazzagli E, La Grotteria M, Orsini R, Leandri L, Vetere NA, Braggion E, Giordanino S, Armando S, Zampieri E, Danese MC, Valentini A, Ferrante MG, Santacroce C, Crocetti I, Macchi F, Bernacchi M, Pini D, Varì M, Lucente M, Scaramastra F, Reichardt S, Gabasio S, Zocchi C, Studhika M, Budzowska E, Cescon M, Lazzari D, Prizzon A, Di Biaggio P, Buda C, Mastrangelo V, Avigliano M, Dell'Aquila L, Bonanomi E, Mezzani A, Porcini F, Girardi G., PERRONE FILARDI, PASQUALE, Rete Infermieri GISSI, Hf, Di Giulio, P, Pera, C, Scarano, M, Ferri, B, Lepore, V, Miani, D, Tognoni, G, Rosson, V, Serafini, C, Zumino, Mt, Partemi, L, Falleroni, Ml, Moretti, L, Porta, L, Santorsola, A, Tenerelli, T, Bertoncelli, B, Mengoli, G, Stagnitto, M, Puddu, Gm, Masini, E, Pasini, A, Boni, S, Valsesia, E, Cornacini, G, Melis, D, Mulina, A, Giurlanda, A, Fava, M, Bellini, P, Vallucci, S, Cuomo, A, Campanale, S, Monatti, G, Bianco, T, Milli, V, Antonelli, L, Fanin, L, Faiola, L, Stefanizzi, R, Mariani, M, Rossi, A, Regnani, St, Loreni, F, Cianfrocca, R, Pisani, A, Faraolfi, V, Ponzalli, P, Savli, T, Cresci, M, Guardalben, S, Belluzzo, B, Ruberti, R, Zizzi, M, Tonda, C, Cadrobbi, Mg, Gilardi, R, Mondì, A, Costa, A, Milan, S, Zottarelli, A, Parodi, B, Sartorio, N, Rossin, B, Santi, A, Cagnan, P, Maradei, E, Cauteruccio, A, Carpino, C, Addeo, R, Izzo, A, Amendola, G, PERRONE FILARDI, Pasquale, Prizzitano, Am, Piluso, Gm, Iadevaio, Al, Cinà, Mt, Cirrincione, V, Gumina, S, Codato, G, Raimondo, F, Cappiello, Mg, Creta, F, Barbieri, M, Chiarella, L, Abbondio, L, Piccin, M, Spillone, V, Cutrupi, G, Ruggeri, A, Sicilia, G, Provengano, A, Marcari, P, Ricci, S, Pazzagli, E, La Grotteria, M, Orsini, R, Leandri, L, Vetere, Na, Braggion, E, Giordanino, S, Armando, S, Zampieri, E, Danese, Mc, Valentini, A, Ferrante, Mg, Santacroce, C, Crocetti, I, Macchi, F, Bernacchi, M, Pini, D, Varì, M, Lucente, M, Scaramastra, F, Reichardt, S, Gabasio, S, Zocchi, C, Studhika, M, Budzowska, E, Cescon, M, Lazzari, D, Prizzon, A, Di Biaggio, P, Buda, C, Mastrangelo, V, Avigliano, M, Dell'Aquila, L, Bonanomi, E, Mezzani, A, Porcini, F, and Girardi, G.
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Aged, 80 and over ,Heart Failure ,Male ,Time Factors ,Depression ,Cardiology ,Prognosis ,Education ,Hospitalization ,Nursing Research ,Sex Factors ,Italy ,Risk Factors ,Prevalence ,Quality of Life ,Humans ,Female ,Mortality ,Cognition Disorders ,Aged ,Randomized Controlled Trials as Topic - Abstract
The prevalence of cognitive impairment (CI) is reported to be higher in heart failure patients than in the general population.To describe the prevalence of CI and to assess its prognostic value on the increased risk of hospitalizations and death over the medium term (3 years).MMSE was administered to 620/745 heart failure patients70 years. Up to 35% of the tested population were classified as mild CI and 12% as moderate. The severity of baseline clinical conditions, as expressed as NYHA classes, do not appear to be associated to different degrees of CI. The subgroup of patients with moderate CI includes higher proportion of people with the lowest educational level, of feminine gender, of higher age (80). Even in a population closely monitored as the one included in the GISSI-HLF trial, it is worth to be underlined that the presence of moderate CI appears to be strongly prognostic of an increased burden of care (hospitalizations), and of death over the whole observation period of the study (3 years).The presence of even mild or moderate CI is prognostic for increased mortality and readmissions for patients of the same NYHA class. In the absence of effective intervention strategies, research should concentrate on the yield, if any, of a systematic screening for CI in heart failure patients.
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- 2009
35. [Quality of life, depression and cognitive functions 5. Depression]
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Rete Infermieri GISSI HF, Di Giulio P, Pera C, Scarano M, Ferri B, Lepore V, Miani D, Tognoni G, Rosson V, Serafini C, Zumino MT, Partemi L, Falleroni ML, Moretti L, Porta L, Santorsola A, Tenerelli T, Bertoncelli B, Mengoli G, Stagnitto M, Puddu GM, Masini E, Pasini A, Boni S, Valsesia E, Cornacini G, Melis D, Mulina A, Giurlanda A, Fava M, Bellini P, Vallucci S, Cuomo A, Campanale S, Monatti G, Bianco T, Milli V, Antonelli L, Fanin L, Faiola L, Stefanizzi R, Mariani M, Rossi A, Regnani ST, Loreni F, Cianfrocca R, Pisani A, Faraolfi V, Ponzalli P, Savli T, Cresci M, Guardalben S, Belluzzo B, Ruberti R, Zizzi M, Tonda C, Cadrobbi MG, Gilardi R, Mondì A, Costa A, Milan S, Zottarelli A, Parodi B, Sartorio N, Rossin B, Santi A, Cagnan P, Maradei E, Cauteruccio A, Carpino C, Addeo R, Izzo A, Amendola G, Prizzitano AM, Piluso GM, Iadevaio AL, Cinà MT, Cirrincione V, Gumina S, Codato G, Raimondo F, Cappiello MG, Creta F, Barbieri M, Chiarella L, Abbondio L, Piccin M, Spillone V, Cutrupi G, Ruggeri A, Sicilia G, Provengano A, Marcari P, Ricci S, Pazzagli E, La Grotteria M, Orsini R, Leandri L, Vetere NA, Braggion E, Giordanino S, Armando S, Zampieri E, Danese MC, Valentini A, Ferrante MG, Santacroce C, Crocetti I, Macchi F, Bernacchi M, Pini D, Varì M, Lucente M, Scaramastra F, Reichardt S, Gabasio S, Zocchi C, Studhika M, Budzowska E, Cescon M, Lazzari D, Prizzon A, Di Biaggio P, Buda C, Mastrangelo V, Avigliano M, Dell'Aquila L, Bonanomi E, Mezzani A, Porcini F, Girardi G., PERRONE FILARDI, PASQUALE, Rete Infermieri GISSI, Hf, Di Giulio, P, Pera, C, Scarano, M, Ferri, B, Lepore, V, Miani, D, Tognoni, G, Rosson, V, Serafini, C, Zumino, Mt, Partemi, L, Falleroni, Ml, Moretti, L, Porta, L, Santorsola, A, Tenerelli, T, Bertoncelli, B, Mengoli, G, Stagnitto, M, Puddu, Gm, Masini, E, Pasini, A, Boni, S, Valsesia, E, Cornacini, G, Melis, D, Mulina, A, Giurlanda, A, Fava, M, Bellini, P, Vallucci, S, Cuomo, A, Campanale, S, Monatti, G, Bianco, T, Milli, V, Antonelli, L, Fanin, L, Faiola, L, Stefanizzi, R, Mariani, M, Rossi, A, Regnani, St, Loreni, F, Cianfrocca, R, Pisani, A, Faraolfi, V, Ponzalli, P, Savli, T, Cresci, M, Guardalben, S, Belluzzo, B, Ruberti, R, Zizzi, M, Tonda, C, Cadrobbi, Mg, Gilardi, R, Mondì, A, Costa, A, Milan, S, Zottarelli, A, Parodi, B, Sartorio, N, Rossin, B, Santi, A, Cagnan, P, Maradei, E, Cauteruccio, A, Carpino, C, Addeo, R, Izzo, A, Amendola, G, PERRONE FILARDI, Pasquale, Prizzitano, Am, Piluso, Gm, Iadevaio, Al, Cinà, Mt, Cirrincione, V, Gumina, S, Codato, G, Raimondo, F, Cappiello, Mg, Creta, F, Barbieri, M, Chiarella, L, Abbondio, L, Piccin, M, Spillone, V, Cutrupi, G, Ruggeri, A, Sicilia, G, Provengano, A, Marcari, P, Ricci, S, Pazzagli, E, La Grotteria, M, Orsini, R, Leandri, L, Vetere, Na, Braggion, E, Giordanino, S, Armando, S, Zampieri, E, Danese, Mc, Valentini, A, Ferrante, Mg, Santacroce, C, Crocetti, I, Macchi, F, Bernacchi, M, Pini, D, Varì, M, Lucente, M, Scaramastra, F, Reichardt, S, Gabasio, S, Zocchi, C, Studhika, M, Budzowska, E, Cescon, M, Lazzari, D, Prizzon, A, Di Biaggio, P, Buda, C, Mastrangelo, V, Avigliano, M, Dell'Aquila, L, Bonanomi, E, Mezzani, A, Porcini, F, and Girardi, G.
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Male ,Time Factors ,Depression ,Health Status ,Cardiology ,Patient Readmission ,Hospitalization ,Nursing Research ,Cognition ,Sex Factors ,Italy ,Risk Factors ,Data Interpretation, Statistical ,Prevalence ,Quality of Life ,Humans ,Female ,Mortality ,Geriatric Assessment ,Aged ,Randomized Controlled Trials as Topic - Abstract
Depression is common in patients with heart failure but its causal and/or prognostic role with respect to the cardiac condition in still a matter of research.To describe the prevalence of depression and to assess its specific prognostic value in terms of increased risk of hospitalizations or death.Overall, 27.5% of 1495 patients experience symptoms of depression. Risk factors for depression are female sex, age70, higher NYHA class, previous hospitalizations and comorbidities. Depressed patients of the same NYHA class are at higher risk for 1 and 3 years mortality and all causes hospital admissions.Depression, assessed with a simple and easy to administer instrument, can add information to clinical variables in the identification of patients at increased risk of mortality and readmissions within the same NYHA class.
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- 2009
36. Mitomycin C as an adjuvant treatment to resected gastric cancer: a 10-year follow-up
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Estape, J., Grau, J.J., Lcobendas, F., Curto, J., Daniels, M., Vinolas, N., and Pera, C.
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Mitomycin -- Adverse and side effects ,Stomach cancer -- Prognosis ,Mitomycin -- Evaluation ,Health - Abstract
Gastric, or stomach, cancer may be treated surgically; surgery may then be followed by chemotherapy. In 1983, the authors published a study including a five-year follow-up of 70 stomach cancer patients. All patients had undergone surgery; 37 patients received by no further treatment (controls), and 33 patients received mitomycin C as adjuvant chemotherapy. At the five-year follow-up, death due to cancer recurrence had occurred in 23 of 37 control-group patients and 7 of 33 treatment-group patients. Thus survival was significantly better in the treatment group. The results of the 10-year follow-up of these same patients are reported here. By 10 years, death due to cancer relapse had occurred in 31 of the 37 control patients, compared with 16 of the 33 treatment-group patients; these survival rates are significantly different. Relapse occurred most frequently in the peritoneal (abdominal) cavity, and there was a lower rate of metastasis (cancer spread) to the liver in patients who had received mitomycin-C than in controls. It is concluded that adjuvant chemotherapy with mitomycin-C following resection for stomach cancer is beneficial, even 10 years after surgery. No cases of delayed toxicity or second cancers were observed in the mitomycin-C group, and the initial toxicity was mild. (Consumer Summary produced by Reliance Medical Information, Inc.)
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- 1991
37. The role of nasal endoscopy in the prescription of allergen immunotherapy
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Schiappoli, M., Dama, A. R., Passalacqua, G., Le Pera, C., and Gianenrico Senna
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Adult ,Male ,Adolescent ,Animals ,Desensitization, Immunologic ,Endoscopy ,Female ,Humans ,Intradermal Tests ,Middle Aged ,Nasal Cavity ,Nasal Obstruction ,Predictive Value of Tests ,Pyroglyphidae ,Rhinitis, Allergic ,Young Adult ,Patient Selection ,Desensitization ,Allergic ,Immunologic ,Rhinitis - Published
- 2013
38. Preliminary trial of a retroperitoneal approach for modified selective distal splenorenal shunt
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Pera, C., Visa, J., Rodes, J., and Teres, J.
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- 1978
- Full Text
- View/download PDF
39. Lymphography of the thyroid gland: Is intraglandular dissemination of thyroid carcinoma possible?
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Fernandez-Cruz, Laureano, Astudillo, E., and Pera, C.
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- 1977
- Full Text
- View/download PDF
40. Cardiovascular events and intensity of treatment in polycythemia vera
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Marchioli, R, Finazzi, G, Specchia, G, Cacciola, R, Cavazzina, R, Cilloni, D, De Stefano, V, Elli, E, Iurlo, A, Latagliata, R, Lunghi, F, Lunghi, M, Marfisi, Rm, Musto, P, Masciulli, A, Musolino, C, Cascavilla, N, Quarta, G, Randi, M. L., Rapezzi, D, Ruggeri, M, Rumi, E, Scortechini, Ar, Santini, S, Scarano, M, Siragusa, S, Spadea, A, Tieghi, A, Angelucci, E, Visani, G, Vannucchi, Am, Specchia G, Barbui T., D'Amico, A, Ferri, B, Guido, C, Marfisi, L, Pera, C, Polidoro, A, Sacco, M, Levantesi, G, Tognoni, G, Barosi, G, Carobbio, A, Leoni, P, Mulattieri, S, Tomassetti, S, Honorati, E, Ricco, A, Albano, F, Pastore, D, Carluccio, P, Mazzone, Am, Rossi, Ar, Finazzi, Mc, Delaini, F, Falanga, A, Rambaldi, A, Guaragna, G, Giannotta, A, Usala, E, Simula, Mp, Pilo, F, Cacciola, E, Pezzella, F, Seria, E, Di Francesco, E, Gallamini, A, Bertolotti, L, Antonioli, E, Guglielmelli, P, Pieri, L, Susini, Mc, Bartalucci, N, Bosi, A, D'Angelo, A, Centorrino, R, Gerace, D, Allegra, A, Cortelezzi, A, De Philippis, C, Ferretti, E, Ciceri, F, Claudiani, S, Malato, S, Trinca, S, Pogliani, Em, Belotti, A, Lanzi, E, Elli, Em, Gaidano, G, Deambrogi, C, Rossi, D, Saglio, G, Rotolo, A, Zanone, C, Bertozzi, I, Tezza, F, Aneloni, V, Quintini, G, Saccullo, G, Caracciolo, C, Cazzola, M, Casetti, I, Elena, C, Landini, B, Barulli, S, Guiducci, B, Lucesole, M, Malerba, L, Isidori, A, Grossi, A, De Stefanis, M, Biagioni, C, Merli, F, Imovilli, A, Codeluppi, K, Rubagotti, S, Romano, N, Bonini, A, Bellesia, E, Martorelli, Mc, Villani, O, Zifarone, E, Zonno, A, Santopietro, V, Za, T, Rossi, E, Ciminello, Am, Betti, S, Alimena, G, Tafuri, A, Breccia, M, Carmosino, I, Pisani, F, Romano, A, D'Andrea, M, Nobile, M, Mantuano, Fs, Rossi, G, Tricarico, M, Rodeghiero, F, Bedin, F, Lissandrini, L, Finotto, S., Marchioli, R, Finazzi, G, Specchia, G, Cacciola, R, Cavazzina, R, Cilloni, D, De Stefano, V, Elli, E, Iurlo, A, Latagliata, R, Lunghi, F, Lunghi, M, Marfisi, RM, Musto, P, Masciulli, A, Musolino, C, Cascavilla, N, Quarta, G, Randi, ML, Rapezzi, D, Ruggeri, M, Rumi, E, Scortechini, AR, Santini, S, Scarano, M, Siragusa, S, Spadea, A, Tieghi, A, Angelucci, E, Visani, G, Vannucchi, AM, Barbui, T, and CYTO-PV Collaborative Group.
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Male ,Hematocrit ,RECURRENT THROMBOSIS ,law.invention ,Aged ,Antineoplastic Agents ,Cardiovascular Diseases ,Combined Modality Therapy ,Female ,Follow-Up Studies ,Humans ,Hydroxyurea ,Janus Kinase 2 ,Middle Aged ,Polycythemia Vera ,Thrombosis ,Phlebotomy ,Medicine (all) ,LEUKOCYTOSIS ,Polycythemia vera ,Randomized controlled trial ,law ,hemic and lymphatic diseases ,ESSENTIAL THROMBOCYTHEMIA ,Clinical endpoint ,Polycythemia Vera, Secondary Prophylaxis ,ESSENTIAL THROMBOCYTHEMIA, RECURRENT THROMBOSIS, RISK-FACTOR, HEMATOCRIT, MANAGEMENT, LEUKOCYTOSIS, PREVENTION, DIAGNOSIS, EFFICACY, WARFARIN ,medicine.diagnostic_test ,Hazard ratio ,General Medicine ,medicine.medical_specialty ,randomized trial ,polycythemia vera ,Cardiovascular event ,DIAGNOSIS ,WARFARIN ,RISK-FACTOR ,Internal medicine ,MANAGEMENT ,medicine ,Myelofibrosis ,Adverse effect ,business.industry ,EFFICACY ,medicine.disease ,PREVENTION ,Surgery ,Polycythemia Vera, Cardiovascular event, hematocrit ,Settore MED/15 - MALATTIE DEL SANGUE ,business - Abstract
A b s t r ac t Background Current treatment recommendations for patients with polycythemia vera call for maintaining a hematocrit of less than 45%, but this therapeutic strategy has not been tested in a randomized clinical trial. Methods We randomly assigned 365 adults with JAK2-positive polycythemia vera who were being treated with phlebotomy, hydroxyurea, or both to receive either more intensive treatment (target hematocrit
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- 2013
41. N-3 fatty acids in patients with multiple cardiovascular risk factors
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Roncaglioni, Maria Carla, Avanzini, Fausto, Barlera, Simona, Marzona, Irene, Milani, Valentina, Tombesi, Massimo, Caimi, Vittorio, Longoni, Paolo, Silletta, Maria Giuseppina, Tognoni, Gianni, Marchioli, Avanzini F, Roberto., Caimi, V, Longoni, P, Marchioli, R, Roncaglioni, Mc, Silletta, Mg, Tognoni, G, Tombesi, M, Barlera, S, Milani, V, Nicolis, Eb, Casola, C, Marzona, I, Massa, E, Marrocco, W, Micalella, M, Avanzini, F, Franzosi, Mg, Geraci, E, Giansiracusa, N, Rocchetti, L, Decarli, A, Satolli, R, Alli, C, Beghi, E, Bertele', V, Volpi, A, Baviera, M, Monesi, L, Pangrazzi, I, Nicolis, E, Clerici, F, Palumbo, A, Sgaroni, G, Pioggiarella, R, Scarano, M, Marfisi, Rm, Flamminio, A, Macino, L, Ferri, B, Pera, C, Polidoro, A, Abbatino, D, Acquati, M, Addorisio, G, Adinolfi, D, Adreani, L, Agistri, Mr, Agneta, A, Agnolio, Ml, Agostini, N, Agostino, G, Airò, A, Alaimo, N, Albano, M, Albano, N, Alecci, G, Alemanno, S, Alexanian, A, Alfarano, M, Alfè, L, Alonzo, N, Alvino, S, Ancora, A, Andiloro, S, Andreatta, E, Angeli, S, Angiari, F, Angilletti, V, Annicchiarico, C, Anzivino, M, Aprea, R, Aprile, A, Aprile, E, Aprile, I, Aprile, L, Armellani, V, Arnetoli, M, Aronica, A, Autiero, V, Bacca, G, Baccalaro, Am, Bacci, M, Baglio, G, Bagnani, M, Baiano, A, Baldari, A, Ballarini, L, Banchi, G, Bandera, R, Bandini, F, Baratella, M, Barbieri, A, Barbieri Vita, A, Bardi, M, Barlocchi, M, Baron, P, Bartoli, M, Basile, A, Basile, F, Basile, S, Battaggia, A, Battaglia, A, Baù, A, Beconcini, G, Beggio, R, Belfiore, Pa, Belicchi, M, Bellamoli, S, Bellini, C, Bellomo, M, Benetollo, C, Benetti, R, Beretta, E, Bertalero, P, Bertaso, Fg, Bertolani, U, Bettelli, G, Biagiotti, G, Bianchi, S, Bianco, G, Biccari, F, Bigioli, F, Bindi, M, Bisanti, G, Bitetti, Em, Blasetti, Mp, Blesi, F, Boato, V, Boga, S, Boidi, E, Boldrin, G, Bollati, A, Bolzan, L, Bolzonella, S, Bonardi, P, Bonato, Gb, Bonci, M, Bonfitto, G, Bonincontro, E, Boninsegna, F, Bonissone, D, Bono, L, Bonollo, E, Borghi, M, Borioli, N, Borsatto, M, Bosco, T, Bosisio Pioltelli, M, Botarelli, C, Botassis, S, Bottini, F, Bottos, C, Bova, G, Bova, V, Bozzani, A, Bozzetto, Rm, Braga, Vt, Braglia, M, Bramati, E, Brazzoli, C, Breglia, G, Brescia, A, Briganti, D, Brigato, G, Brocchi, A, Brosio, Fa, Bruni, E, Buscaglia, E, Bussini, Md, Bussotti, A, Buzzaccarini, F, Buzzatti, A, Caccamo, G, Cacciavillani, C, Caggiano, G, Calciano, Fp, Calderisi, M, Calienno, S, Caltagirone, P, Calzolari, I, Cammisa, M, Campanaro, M, Campanella, Gb, Campese, F, Canali, G, Candiani, De, Canepa, R, Canini, D, Canino, A, Cantoro, Ea, Capilupi, V, Capotosto, P, Cappelli, B, Capraro, G, Carafa, Fa, Carano, Q, Carcaterra, V, Carriero, D, Carrozzo, G, Cartanese, M, Casalena, M, Casarola, M, Caso, C, Casotto, M, Castaldi, F, Castegnaro, R, Castellani, G, Castri, S, Catalano, E, Catinello, N, Caturano, G, Cavallaro, R, Cavallo, Am, Cavallo, G, Cavion, Mt, Cavirani, G, Cazzaniga, F, Cazzetta, D, Cecconi, V, Cefalo, A, Celebrano, M, Celora, A, Centonze, P, Cerati, D, Cesaretti, D, Checchia, G, Checchin, A, Cherubini, M, Chianese, L, Chiappa, A, Chiappa, Mv, Chiariello, G, Chiavini, G, Chicco, M, Chiumeo, F, Ciacciarelli, A, Ciaci, D, Ciancaglini, R, Cicale, C, Cicale, S, Cipolla, A, Ciruolo, A, Citeri, Al, Citterio, G, Clerici, M, Coazzoli, E, Collecchia, G, Colletta, F, Colombo, I, Colorio, P, Coluccia, S, Comerio, M, Comoretto, P, Compagni, M, Conte, O, Contri, S, Contrisciani, A, Coppetti, T, Corasaniti, F, Corradi, Mt, Corsano, A, Corsini, A, Corti, N, Costantini, G, Costantino, A, Cotroneo, S, Cozzi, D, Cravello, Mg, Cristiano, E, Cucchi, R, Cusmai, L, D' Errico GB, D'Agostino, P, Dal Bianco, L, Dal Mutto, U, Dal Pozzo, G, Dallapiccola, P, Dallatorre, G, Dalle Molle, G, Dalloni, E, D'Aloiso, A, D'Amicis, G, Danese, R, Danieli, D, Danisi, G, D'Anna, Ma, Danti, G, D'Ascanio, S, Davidde, G, De Angeli, D, De Bastiani, R, De Battisti, A, De Bellis, A, De Berardinis, G, De Carlo, F, De Giorgi, D, De Gobbi, R, De Lorenzis, E, De Luca, P, De Martini, G, De Marzi, M, De Matteis, D, De Padova, S, De Polo, P, De Sabato, N, De Stefano, T, De Vita MT, De Vita, U, De Zolt, V, Debernardi, F, Del Carlo, A, Del Re, G, Del Zotti, F, D'Elia, R, Della Giovanna, P, Dell'Acqua, L, Dell'Orco, Rl, Demaria, G, Di Benedetto MG, Di Chiara, G, Di Corcia, V, Di Domizio, O, Di Donato, P, Di Donato, S, Di Fermo, G, Di Franco, M, Di Giovannantonio, G, Di Lascio, G, Di Lecce, G, Di Lorenzo, N, Di Maro, T, Di Mattia, Q, Di Michele, E, Di Modica RS, Di Murro, D, Di Noi MC, Di Paoli, V, Di Santi, M, Di Sanzo, A, Di Turi, C, Diazzi, A, Dileo, I, D'Ingianna, Ap, Dolci, A, Donà, G, Donato, C, Donato, P, Donini, A, Donna, Me, Donvito, Tv, Esposito, L, Esposito, N, Evangelista, M, Faita, G, Falco, M, Falcone, Da, Falorni, F, Fanciullacci, A, Fanton, L, Fasolo, L, Fassina, R, Fassone, A, Fatarella, P, Fedele, F, Fera, I, Fera, L, Ferioli, S, Ferlini, Mg, Ferlino, R, Ferrante, G, Ferrara, Fn, Ferrarese, Mf, Ferrari, G, Ferrari, O, Ferreri, A, Ferroni, M, Fezzi, G, Figaroli, C, Fina, Mg, Fioretta, A, Fiorucci, C, Firrincieli, R, Fischetti, M, Fischietti, G, Fiume, Dc, Flecchia, G, Forastiere, G, Fossati, B, Franceschi, Pl, Franchi, L, Franzoso, F, Frapporti, G, Frasca, G, Frisotti, A, Fumagalli, G, Fusco, D, Gabriele, P, Gabrieli, A, Gagliano, D, Galimberti, G, Galli, A, Gallicchio, N, Gallio, F, Gallipoli, T, Gallo, P, Galopin, T, Gambarelli, L, Garbin, A, Garozzo, Gm, Gasparri, R, Gastaldo, M, Gatti, E, Gazzaniga, P, Gennachi, N, Gentile, Rv, Germani, P, Gesualdi, F, Gherardi, E, Ghezzi, C, Ghidini, Mg, Ghionda, F, Giacci, L, Gialdini, D, Giampaolo, C, Giancane, R, Giannanti, A, Giannese, S, Giannini, L, Giaretta, M, Giaretta, R, Giavardi, L, Giordano, P, Giordano, E, Giordano, B, Gioria, Gm, Giugliano, R, Grassi, Ea, Greco, A, Greco, L, Grilletti, N, Grimaldi, N, Grisetti, G, Groppelli, G, Gualtieri, L, Guarducci, M, Guastella, G, Guerra, M, Guerrini, F, Guglielmini, A, Guido, A, Gulotta, P, Iacono, E, Iadarola, G, Ianiro, G, Iarussi, V, Ieluzzi, Ml, Ierardi, C, Ingaldi, F, Interlandi, S, Iocca, M, Iorno, A, Ioverno, E, Iurato, R, La Pace, L, La Piscopia, C, La Selva, R, Lafratta, M, Lamparelli, M, Lanaro, G, Lancerotto, R, Larcher, M, Lassandro, M, Lattuada, G, Laurino, P, Lefons, C, Legrottaglie, F, Lemma, A, Leone, D, Leone, F, Leso, A, Leuzzi, G, Levato, G, Libardi, L, Libralesso, N, Licini, Pi, Licursi, G, Lidonnici, F, Lillo, C, Liveri, L, Livio, A, Loiero, Ra, Loison, M, Lombardo, G, Lombardo, T, Lomunno, V, Lomuscio, S, Lonedo, A, Longo, E, Lora, L, Lotterio, A, Lucatello, L, Luongo, A, Lupoli, M, Macchia, C, Macri, G, Mafessanti, M, Maggialetti, V, Maggioni, A, Magnani, M, Maiellaro, G, Mancuso, A, Maniglio, Ar, Mannari, Gl, Manni, A, Manocchio, B, Mao, M, Maranò, A, Maraone, E, Marascio, D, Marcheselli, P, Marchetto, B, Marchetto, S, Marchi, A, Marchi, Gl, Mariano, C, Marinacci, S, Marinelli, S, Marini, G, Marra, Vc, Marrali, F, Marseglia, C, Martello, G, Martino, C, Martino, G, Martino, M, Marulli, Cf, Maruzzi, G, Marzotti, A, Mascheroni, G, Mascolo, P, Masoch, G, Masone, R, Massa, L, Massafra, M, Massi, M, Massignani, Dm, Matarese, Am, Matini, G, Mauro, R, Mazzi, M, Mazzillo, A, Mazzocato, E, Mazzoleni, Ns, Mazzone, A, Melacci, A, Mele, E, Meliota, P, Menaspà, S, Meneghello, F, Merola, G, Merone, L, Metrucci, A, Mezzina, V, Micchi, A, Michielon, A, Migliore, N, Minero, G, Minotta, F, Mirandola, C, Mistrorigo, S, Modafferi, L, Moitre, R, Mola, E, Monachese, C, Mongiardini, C, Montagna, F, Montani, M, Montemurno, I, Montolli, R, Montorsi, S, Montresor, M, Monzani, Mg, Morabito, F, Mori, G, Moro, A, Mosca, Mf, Motti, F, Muddolon, L, Mugnai, M, Muscas, F, Naimoli, F, Nanci, G, Nargi, E, Nasorri, R, Nastrini, G, Negossi, M, Negrini, A, Negroni, A, Neola, V, Niccolini, F, Niro, Cm, Nosengo, C, Novella, G, Nuti, C, Obici, F, Olita, C, Oliverio, Ss, Olivieri, I, Oriente, S, Orlando, G, Paci, C, Pagano, G, Pagliara, C, Paita, G, Paladini, G, Paladino, G, Palano, T, Palatella, A, Palermo, P, Palmisano, M, Pando, P, Panessa, P, Panigo, F, Panozzo, G, Panvini, F, Panzieri, F, Panzino, A, Panzitta, F, Paoli, N, Papagna, R, Papaleo, Mg, Papalia, G, Parisi, R, Parotti, N, Parravicini, D, Passarella, P, Pastore, Ga, Patafio, M, Pavone, P, Pedroli, W, Pedroni, M, Pelligra, G, Pellizzari, M, Penati, A, Perlot, M, Perrone, A, Perrone, G, Peruzzi, P, Peselli, C, Petracchini, L, Petrera, L, Petrone, S, Peverelli, C, Pianorsi, F, Piazza, Gp, Piazzolla, G, Picci, A, Pienabarca, G, Pietronigro, Tp, Pignocchino, P, Pilone, R, Pinto, D, Pirovano, E, Pirrotta, D, Pisante, V, Pitotto, P, Pittari, L, Piva, A, Pizzoglio, A, Plantera, Or, Plebani, W, Plessi, S, Podrecca, D, Poerio, V, Poggiani, F, Pogliani, W, Poli, L, Poloni, Fg, Porcelli, R, Porto, S, Pranzo, L, Prevedello, C, Profeta, C, Profico, D, Punzi, A, Quaglia, Gm, Racano, M, Raccone, A, Radice, F, Raho, Ca, Raimondi, R, Rainò, M, Ramponi, R, Ramunni, A, Ramunni, Al, Ravasio, F, Ravera, M, Re Sartò, G, Rebustello, G, Regazzoli, S, Restelli, C, Rezzonico, M, Ricchiuto, F, Rigo, S, Rigon, G, Rigon, R, Rinaldi, Ov, Rinaldi, M, Risplendente, Pg, Rispoli, M, Riundi, R, Riva, Mg, Rizzi, Al, Rizzi, D, Rizzo, Ld, Rocchi, L, Rondinone, B, Rosa, B, Rosati, F, Roselli, F, Rossetti, A, Rossetti, C, Rossi, R, Rossi, Pr, Rossi, A, Rossi, Cl, Rossitto, A, Ruffini, R, Ruffo, A, Ruggio, S, Ruo, M, Russo, B, Russo, L, Russo, R, Russo, S, Russo, U, Russo, V, Ruta, G, Sacchi, F, Sacco Botto, F, Saia, A, Salladini, G, Salmoiraghi, S, Saluzzo, F, Salvatore, C, Salvatori, E, Salvio, G, Sandri, P, Sandrini, T, Sangermano, V, Santoni, N, Saracino, Ad, Saracino, A, Sarasin, P, Sardo Infirri, C, Sarrì, B, Sartori, G, Sartori, N, Sauro, C, Scaglioni, M, Scalfi, C, Scamardella, Am, Scandale, G, Scandone, L, Scannavini, G, Scarati, R, Scardi, A, Scarpa, Fm, Scazzi, P, Schifone, A, Schirosa, G, Scigliano, G, Scilla, A, Sciortino, M, Scolaro, G, Scollo, E, Scorretti, G, Sellitti, R, Selmo, A, Selvaggio, G, Sempio, A, Seren, F, Serio, L, Serra, C, Serra, L, Siciliano, D, Sideri, A, Sighele, M, Signore, R, Siliberto, F, Silvestro, M, Simioni, G, Simmini, G, Simonato, L, Sinchetto, F, Sizzano, E, Smajato, G, Smaldone, M, Sola, G, Sordillo, L, Sovran, Cs, Spagnul, P, Spanò, F, Sproviero, S, Squintani, A, Stella, L, Stilo, V, Stocchiero, B, Stornello, Mc, Stracka, G, Strada, S, Stranieri, G, Stucci, N, Stufano, N, Suppa, A, Susca, Vg, Sutti, M, Taddei, M, Tagliabue, E, Tagliente, G, Talato, F, Talerico, P, Talia, R, Taranto, R, Tartaglia, M, Tauro, N, Tedesco, A, Tieri, P, Tirelli, M, Tocci, L, Todesco, P, Tognolo, M, Tomba, A, Tonello, P, Tonon, R, Toscano, L, Tosi, A, Tosi, G, Toso, S, Travaglio, P, Tremul, L, Tresso, C, Triacchini, P, Triggiano, L, Trigilio, A, Trimeloni, J, Tripicchio, G, Tritto, Gs, Trono, F, Trotta, E, Trotta, G, Tubertini, A, Turri, C, Turri, L, Tuttolani, Mp, Urago, M, Ursini, G, Valcanover, F, Valente, L, Valenti, M, Valentini, F, Vallone, G, Valz, P, Valzano, L, Vanin, V, Vatteroni, M, Vegetti, L, Vendrame, D, Veramonti, I, Veronelli, G, Vesco, A, Vicariotto, G, Vignale, G, Villa, Pl, Vinciguerra, R, Visco, A, Visentin, G, Visonà, E, Vitali, E, Vitali, S, Vitti, F, Volpone, Da, Zambon, N, Zammarrelli, A, Zanaboni, A, Zane, D, Zanetti, B, Zanibellato, R, Zappetti, M, Zappone, P, Zerilli, G, Zirino, V, Zoccali, R, Zuin, F, Altomonte, M, Anelli, N, Angiò, F, Annale, P, Antonacci, S, Anzilotta, R, Bano, F, Basadonna, O, Beduschi, L, Becagli, P, Bellotti, G, Blotta, C, Bruno, G, Cappuccini, A, Caramatti, S, Cariolato, Mp, Castellana, M, Castellani, L, Catania, R, Chielli, A, Chinellato, A, Ciaccia, A, Clerici, E, Cocci, A, Costanzo, G, D'Ercole, F, De Stefano, G, Decè, F, Di Cicco, N, Di Marco, A, Donati Sarti, C, Draghi, E, Dusi, G, Esposito, V, Ferraro, L, Ferretti, A, Ferri, E, Foggetti, L, Foglia, A, Fonzi, E, Frau, G, Fuoco, Mr, Furci, G, Gallo, L, Garra, V, Giannini, A, Gris, A, Iacovino, R, Interrigi, R, Joppi, R, Laner, B, La Fortezza, G, La Padula, A, Lista, Mr, Lupi, G, Maffei, D, Maggioni, G, Magnani, L, Marrazzo, E, Marcon, L, Marinò, V, Maroni, A, Martinelli, C, Mastandrea, E, Mastropierro, F, Meo, At, Mero, P, Minesso, E, Moschetta, V, Mosele, E, Nanni, C, Negretti, A, Nisticò, C, Orsini, A, Osti, M, Pacilli, Mc, Pennestre, C, Picerno, G, Piol, K, Pivano, L, Pizzuti, E, Poggi, L, Poidomani, I, Pozzetto, M, Presti, Ml, Ravani, R, Recalenda, V, Romagnuolo, F, Rossignoli, S, Rossin, E, Sabatella, C, Sacco, F, Sanità, F, Sansone, E, Servadei, F, Sisto, Mt, Sorio, A, Sorrentino, A, Spinelli, E, Spolaor, A, Squillacioti, A, Stella, P, Talerico, A, Todisco, C, Vadino, M, and Zuliani, C.
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Male ,medicine.medical_specialty ,General Practice ,Kaplan-Meier Estimate ,Placebo ,Double-Blind Method ,Risk Factors ,Internal medicine ,Fatty Acids, Omega-3 ,Clinical endpoint ,medicine ,Humans ,Myocardial infarction ,Treatment Failure ,Aged ,Proportional Hazards Models ,chemistry.chemical_classification ,Omega-3 ,business.industry ,Proportional hazards model ,Medicine (all) ,Hazard ratio ,Fatty Acids ,General Medicine ,Middle Aged ,medicine.disease ,Hospitalization ,Primary Prevention ,chemistry ,Cardiovascular Diseases ,Heart failure ,Cohort ,Female ,business ,Polyunsaturated fatty acid - Abstract
Background Trials have shown a beneficial effect of n-3 polyunsaturated fatty acids in patients with a previous myocardial infarction or heart failure. We evaluated the potential benefit of such therapy in patients with multiple cardiovascular risk factors or atherosclerotic vascular disease who had not had a myocardial infarction. Methods In this double-blind, placebo-controlled clinical trial, we enrolled a cohort of patients who were followed by a network of 860 general practitioners in Italy. Eligible patients were men and women with multiple cardiovascular risk factors or atherosclerotic vascular disease but not myocardial infarction. Patients were randomly assigned to n-3 fatty acids (1 g daily) or placebo (olive oil). The initially specified primary end point was the cumulative rate of death, nonfatal myocardial infarction, and nonfatal stroke. At 1 year, after the event rate was found to be lower than anticipated, the primary end point was revised as time to death from cardiovascular causes or admission to the hospital for cardiovascular causes. Results Of the 12,513 patients enrolled, 6244 were randomly assigned to n-3 fatty acids and 6269 to placebo. With a median of 5 years of follow-up, the primary end point occurred in 1478 of 12,505 patients included in the analysis (11.8%), of whom 733 of 6239 (11.7%) had received n-3 fatty acids and 745 of 6266 (11.9%) had received placebo (adjusted hazard ratio with n-3 fatty acids, 0.97; 95% confidence interval, 0.88 to 1.08; P=0.58). The same null results were observed for all the secondary end points. Conclusions In a large general-practice cohort of patients with multiple cardiovascular risk factors, daily treatment with n-3 fatty acids did not reduce cardiovascular mortality and morbidity. (Funded by Societa Prodotti Antibiotici and others; ClinicalTrials.gov number, NCT00317707.).
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- 2013
42. The Romanian Population Health State Analysis near Kosloduy NPP, Bulgaria
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Antonescu, E, primary, Dadulescu, E, additional, Mossang, D, additional, Sorop, I, additional, Prunariu, L, additional, Pera, C, additional, and Ciuvat, B, additional
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- 2015
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43. Once-daily prolonged-release Tacrolimus (ADVAGRAF) versus twice-daily Tacrolimus (PROGRAF) in liver transplantation
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Trunecka, P, Boillot, O, Seehofer, D, Pinna, Ad, Fischer, L, Ericzon, Bg, Troisi, Ri, Baccarani, U, ORTIZ DE URBINA, J, Wall, W, Mccaughan, G, Jones, R, DE ROOVER, A, Mies, S, Moreira, L, Lima, A, Cantisani, G, Kneteman, N, Grant, D, Roy, A, Scudamore, C, Tchervenkov, J, Clavien, P, Candinas, D, Schmidt, J, Schlitt, J, Bilbao, I, Charco, R, Pera, C, Bernardos, A, MIR PALLARDO, J, Varo, E, Isoniemi, H, Rostaing, L, Samuel, D, Pageaux, G, Durand, F, Duvoux, C, Boudjema, K, Wolf, P, Burroughs, A, O' GRADY, J, Prasad, R, Manas, D, Mccormick, A, Colledan, M, Valente, Umberto, Gerunda, G, Gridelli, B, Bentdal, O, Munn, S, Paczek, L, Bäckman, L., Trunecka P., Boillot O., Seehofer D., Pinna A.D., Fischer L., Ericzon B.G., Troisi R.I., Baccarani U., Ortiz de Urbina J., Wall W., and Tacrolimus Prolonged Release Liver Study Group
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Adult ,Graft Rejection ,Male ,medicine.medical_specialty ,Randomization ,medicine.medical_treatment ,Urology ,chemical and pharmacologic phenomena ,Liver transplantation ,Kidney Function Tests ,Tacrolimus ,Daclizumab ,medicine ,Humans ,Immunology and Allergy ,Pharmacology (medical) ,Adverse effect ,Antibacterial agent ,Transplantation ,Protein synthesis inhibitor ,business.industry ,tacrolimu ,Middle Aged ,Liver Transplantation ,Surgery ,Multicenter Study ,Calcineurin ,Treatment Outcome ,surgical procedures, operative ,Randomized Controlled Trial ,Immunosuppression ,Steroids ,RCT ,Female ,business ,Immunosuppressive Agents ,medicine.drug - Abstract
The efficacy and safety of dual-therapy regimens of twice-daily tacrolimus (BID; Prograf) and once-daily tacrolimus (QD; Advagraf) administered with steroids, without antibody induction, were compared in a multicenter, 1:1-randomized, two-arm, parallel-group study in 475 primary liver transplant recipients. A double-blind, double-dummy 24-week period was followed by an open extension to 12 months posttransplant. The primary endpoint, event rate of biopsy-proven acute rejection (BPAR) at 24 weeks, was 33.7% for tacrolimus BID versus 36.3% for tacrolimus QD (Per-protocol set; p = 0.512; treatment difference 2.6%, 95% confidence interval -7.3%, 12.4%), falling within the predefined 15% noninferiority margin. At 12 months, BPAR episodes requiring treatment were similar for tacrolimus BID and QD (28.1% and 24.7%). Twelve-month patient and graft survival was 90.8% and 85.6% for tacrolimus BID and 89.2% and 85.3% for tacrolimus QD. Adverse event (AE) profiles were similar for both tacrolimus BID and QD with comparable incidences of AEs and serious AEs. Tacrolimus QD was well tolerated with similar efficacy and safety profiles to tacrolimus BID.
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- 2010
44. Cooperative learning strategies to teach nutrition to geriatric nursing staff
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Arroyo, M., A M Rocandio Pablo, Ansotegui, L., Pascual, E., and La Pera, C. M.
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education program ,enfermeros/as ,MEDICINE ,geriatric nutrition ,Aprendizaje cooperativo ,NUTRITION AND DIETETICS ,assessment of knowledge ,enfermeras ,Cooperative learning ,cooperative learning ,nurses ,evaluación de conocimientos ,aprendizaje cooperativo ,auxiliares de enfermería ,programas de educación ,nutrición geriátrica ,enfermeros ,nursing assistants - Abstract
[EN] The objective of this study was to test the hypothesis that cooperative learning strategies will help to increase nutrition knowledge of nurses and nursing assistants caring for the elderly in different institutional communities of the Basque Country, Spain. The target population was a sample of volunteers, 16 nurses and 28 nursing assistants. Training consisted of 12 nutrition education sessions using cooperative strategies conducted over a period of 3 consecutive weeks. The assessment instruments included two pretest and two posttest questionnaires with questions selected in multiplechoice format. The first questionnaire was about general knowledge of applied nutrition (0-88 point scale) and the second one on geriatric nutrition knowledge (0-18 point scale). Data were analyzed using SPSS vs. 11.0. The outcomes indicated a significant increase in general nutrition knowledge (difference between the pre- and posttest mean score: 14.5±10.1; P
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- 2008
45. A complex chemical kinetic mechanism for the oxidation of gasoline surrogate fuels: n heptane, iso octane and toluene - Mechanism development and validation
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Da Cruz, A. Pires, Pera, C., Anderlohr, Jörg, Bounaceur, Roda, Battin-Leclerc, Frédérique, IFP Energies nouvelles (IFPEN), Département de Chimie Physique des Réactions (DCPR), and Institut National Polytechnique de Lorraine (INPL)-Centre National de la Recherche Scientifique (CNRS)
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Chemical Physics (physics.chem-ph) ,Physics - Chemical Physics ,FOS: Physical sciences ,[PHYS.PHYS.PHYS-CHEM-PH]Physics [physics]/Physics [physics]/Chemical Physics [physics.chem-ph] - Abstract
The development and validation against experimental results of a new gasoline surrogate complex kinetic mechanism is presented in this paper. The surrogate fuel is a ternary mixture of n heptane, iso octane and toluene. The full three components mechanism is based on existing n heptane/iso octane (gasoline PRF) and toluene mechanisms which were modified and coupled for the purpose of this work. Mechanism results are compared against available experimental data from the literature. Simulations with the PRF plus toluene mechanism show that its behavior is in agreement with experimental results for most of the tested settings. These include a wide variety of thermodynamic conditions and fuel proportions in experimental configurations such as HCCI engine experiments, rapid compression machines, a shock tube and a jet stirred reactor., Comment: Proceedings of the European Combustion Meeting 2007, Chania : Gr\`ece (2007)
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- 2007
46. Implementation of a Medical Data Manager on top of gLite services
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Montagnat, J, Jouvenot, D, Pera, C, Frohner, Á, Kunszt, Peter Z, Koblitz, B, Santos, N, and Loomis, C
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Computing and Computers - Abstract
This report describes the effort to deploy a Medical Data Management service on top of the EGEE grid infrastructure. The most widely accepted medical image standard, DICOM, was developed for fulfilling clinical practice. It is implemented in most medical image acquisition and analysis devices. The EGEE middleware is using the SRM standard for handling grid files. Our prototype is exposing an SRM compliant interface to the grid middleware, transforming on the fly SRM requests into DICOM transactions. The prototype ensures user identification, strict file access control and data protection through the use of relevant grid services. This Medical Data Manager is easing the access to medical databases needed for many medical data analysis applications deployed today. It offers a high level data management service, compatible with clinical practices, which encourages the migration of medical applications towards grid infrastructures. A limited scale testbed has been deployed as a proof of concept of this new service. The service is expected to be put into production with the next EGEE middleware generation.
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- 2006
47. Antiviral drugs can inhibit lymphocyte apoptosis induced by cytomegalovirus antigens
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Briceño, J, de la Torre-Cisneros, J, Alvarez-Kindelan, A, Sanchez-Guijo, P, and Pera, C
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- 2001
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48. Ulcera p�ptica post operatoria
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Pera, C., primary
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49. Benign Strictures of the Terminal Common Bile Duct
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Fernandez-Cruz, L., primary, Palacin, A., additional, and Pera, C., additional
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50. A Histological Study of the Sphincter of Oddi
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Fernandez-Cruz, L., primary and Pera, C., additional
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- View/download PDF
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