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5. SMA-miRs (MiR-181a- 5p, -324-5p, and -451a) are overexpressed in spinal muscular atrophy skeletal muscle and serum samples

Author

Abiusi, E., Infante, P., Cagnoli, C., Severini, L. L., Pane, M., Coratti, G., Pera, M. C., D'amico, A., Diano, F., Novelli, A., Spartano, S., Fiori, S., Baranello, G., Moroni, I., Mora, M., Pasanisi, M. B., Pocino, K., Le Pera, L., D'Amico, D., Travaglini, L., Ria, F., Bruno, C., Locatelli, D., Bertini, E. S., Morandi, L. O., Mercuri, E., Di Marcotullio, L., Tiziano, F. D., Abiusi E. (ORCID:0000-0001-9028-012X), Pane M. (ORCID:0000-0002-4851-6124), Coratti G. (ORCID:0000-0001-6666-5628), Pera M. C. (ORCID:0000-0001-6777-1721), D'amico A., Diano F., Novelli A., Spartano S., Fiori S., Baranello G., Pocino K. (ORCID:0000-0003-2456-5308), Ria F. (ORCID:0000-0002-8444-0307), Bertini E. S., Mercuri E. (ORCID:0000-0002-9851-5365), Tiziano F. D. (ORCID:0000-0002-5545-6158), Abiusi, E., Infante, P., Cagnoli, C., Severini, L. L., Pane, M., Coratti, G., Pera, M. C., D'amico, A., Diano, F., Novelli, A., Spartano, S., Fiori, S., Baranello, G., Moroni, I., Mora, M., Pasanisi, M. B., Pocino, K., Le Pera, L., D'Amico, D., Travaglini, L., Ria, F., Bruno, C., Locatelli, D., Bertini, E. S., Morandi, L. O., Mercuri, E., Di Marcotullio, L., Tiziano, F. D., Abiusi E. (ORCID:0000-0001-9028-012X), Pane M. (ORCID:0000-0002-4851-6124), Coratti G. (ORCID:0000-0001-6666-5628), Pera M. C. (ORCID:0000-0001-6777-1721), D'amico A., Diano F., Novelli A., Spartano S., Fiori S., Baranello G., Pocino K. (ORCID:0000-0003-2456-5308), Ria F. (ORCID:0000-0002-8444-0307), Bertini E. S., Mercuri E. (ORCID:0000-0002-9851-5365), and Tiziano F. D. (ORCID:0000-0002-5545-6158)

Abstract

Background: Spinal muscular atrophy (SMA) is a neuromuscular disorder characterized by the degeneration of the second motor neuron. The phenotype ranges from very severe to very mild forms. All patients have the homozygous loss of the SMN1 gene and a variable number of SMN2 (generally 2–4 copies), inversely related to the severity. The amazing results of the available treatments have made compelling the need of prognostic biomarkers to predict the progression trajectories of patients. Besides the SMN2 products, few other biomarkers have been evaluated so far, including some miRs. Methods: We performed whole miRNome analysis of muscle samples of patients and controls (14 biopsies and 9 cultures). The levels of muscle differentially expressed miRs were evaluated in serum samples (51 patients and 37 controls) and integrated with SMN2 copies, SMN2 full-length transcript levels in blood and age (SMA-score). Results: Over 100 miRs were differentially expressed in SMA muscle; 3 of them (hsa-miR-181a-5p, -324-5p, -451a; SMA-miRs) were significantly upregulated in the serum of patients. The severity predicted by the SMA-score was related to that of the clinical classification at a correlation coefficient of 0.87 (p<10-5). Conclusions: MiRNome analyses suggest the primary involvement of skeletal muscle in SMA pathogenesis. The SMA-miRs are likely actively released in the blood flow; their function and target cells require to be elucidated. The accuracy of the SMA-score needs to be verified in replicative studies: If confirmed, its use could be crucial for the routine prognostic assessment, also in presymptomatic patients.

Published
2021

6. SMA-miRs (MiR-181a- 5p, -324-5p, and -451a) are overexpressed in spinal muscular atrophy skeletal muscle and serum samples

Author

Abiusi, Emanuela, Infante, P., Cagnoli, C., Severini, L. L., Pane, Marika, Coratti, Giorgia, Pera, Maria Carmela, D'Amico, Adele, Diano, Federica, Novelli, Agnese, Spartano, Serena, Fiori, Simona, Baranello, Giovanni, Moroni, I., Mora, M., Pasanisi, M. B., Pocino, Krizia, Le Pera, L., D'Amico, D., Travaglini, L., Ria, Francesco, Bruno, C., Locatelli, D., Bertini, Enrico Silvio, Morandi, L. O., Mercuri, Eugenio Maria, Di Marcotullio, L., Tiziano, Francesco Danilo, Abiusi E. (ORCID:0000-0001-9028-012X), Pane M. (ORCID:0000-0002-4851-6124), Coratti G. (ORCID:0000-0001-6666-5628), Pera M. C. (ORCID:0000-0001-6777-1721), D'amico A., Diano F., Novelli A., Spartano S., Fiori S., Baranello G., Pocino K. (ORCID:0000-0003-2456-5308), Ria F. (ORCID:0000-0002-8444-0307), Bertini E. S., Mercuri E. (ORCID:0000-0002-9851-5365), Tiziano F. D. (ORCID:0000-0002-5545-6158), Abiusi, Emanuela, Infante, P., Cagnoli, C., Severini, L. L., Pane, Marika, Coratti, Giorgia, Pera, Maria Carmela, D'Amico, Adele, Diano, Federica, Novelli, Agnese, Spartano, Serena, Fiori, Simona, Baranello, Giovanni, Moroni, I., Mora, M., Pasanisi, M. B., Pocino, Krizia, Le Pera, L., D'Amico, D., Travaglini, L., Ria, Francesco, Bruno, C., Locatelli, D., Bertini, Enrico Silvio, Morandi, L. O., Mercuri, Eugenio Maria, Di Marcotullio, L., Tiziano, Francesco Danilo, Abiusi E. (ORCID:0000-0001-9028-012X), Pane M. (ORCID:0000-0002-4851-6124), Coratti G. (ORCID:0000-0001-6666-5628), Pera M. C. (ORCID:0000-0001-6777-1721), D'amico A., Diano F., Novelli A., Spartano S., Fiori S., Baranello G., Pocino K. (ORCID:0000-0003-2456-5308), Ria F. (ORCID:0000-0002-8444-0307), Bertini E. S., Mercuri E. (ORCID:0000-0002-9851-5365), and Tiziano F. D. (ORCID:0000-0002-5545-6158)

Abstract

Background: Spinal muscular atrophy (SMA) is a neuromuscular disorder characterized by the degeneration of the second motor neuron. The phenotype ranges from very severe to very mild forms. All patients have the homozygous loss of the SMN1 gene and a variable number of SMN2 (generally 2–4 copies), inversely related to the severity. The amazing results of the available treatments have made compelling the need of prognostic biomarkers to predict the progression trajectories of patients. Besides the SMN2 products, few other biomarkers have been evaluated so far, including some miRs. Methods: We performed whole miRNome analysis of muscle samples of patients and controls (14 biopsies and 9 cultures). The levels of muscle differentially expressed miRs were evaluated in serum samples (51 patients and 37 controls) and integrated with SMN2 copies, SMN2 full-length transcript levels in blood and age (SMA-score). Results: Over 100 miRs were differentially expressed in SMA muscle; 3 of them (hsa-miR-181a-5p, -324-5p, -451a; SMA-miRs) were significantly upregulated in the serum of patients. The severity predicted by the SMA-score was related to that of the clinical classification at a correlation coefficient of 0.87 (p<10-5). Conclusions: MiRNome analyses suggest the primary involvement of skeletal muscle in SMA pathogenesis. The SMA-miRs are likely actively released in the blood flow; their function and target cells require to be elucidated. The accuracy of the SMA-score needs to be verified in replicative studies: If confirmed, its use could be crucial for the routine prognostic assessment, also in presymptomatic patients.

Published
2021

8. Event series: Open Science and Covid-19. Working together to fight the pandemic

Author

De Leo F., Lazzeri E., Le Pera L., Pavone G., and Via A.

Subjects
Coronavirus Disease Research Community - COVID-19 Open Science in Italy
Abstract

L'emergenza sanitaria da Covid-19 ha reso evidente la necessità di collaborare a livello globale. Per trovare soluzioni rapide ed efficaci alla pandemia è doveroso condividere nel modo più aperto possibile dati, pubblicazioni, software e altre tipologie di risultati scientifici. Se ne parlerà in una serie di webinar e tutorial organizzati dai nodi italiani di OpenAIRE, ELIXIR, RDA e EOSC Pillar.

Published
2020

12. The role of the intensive care unit in real-time surveillance of emerging pandemics: the Italian GiViTI experience

Author

Bertolini, G, Nattino, G, Langer, M, Tavola, M, Crespi, D, Mondini, M, Rossi, C, Previtali, C, Marshall, J, Poole, D, Abascià, A, Acquarolo, A, Adorni, A, Agnelli, V, Agostini, F, Alampi, D, Alberti, A, Alborghetti, A, Alleva, S, Ambrosoni, S, Antonini, B, Arditi, E, Avalli, L, Babini, M, Bagalini, G, Balata, A, Balicco, B, Barbagallo, M, Bartoli, T, Bassi, G, Becarelli, S, Beck, E, Bellin, M, Bellonzi, A, Bellorini, M, Benanti, C, Bensi, M, Bernasconi, Mo, Berruto, F, Bertolini, R, Besozzi, A, Biamino, C, Bianchi, T, Bianchin, A, Boccalatte, D, Bocchi, A, Bonaccorso, G, Bonazzi, M, Balsamo, C, Bonicalzi, V, Boniotti, C, Bonizzoli, M, Bottazzi, A, Breschi, C, Brizio, E, Brunetti, B, Brunori, E, Bubbico, G, Buscaglia, G, Calicchio, G, Calligaro, P, Calva, S, Candido, M, Capitanio, G, Caroleo, S, Casagli, S, Casalini, P, Castiglione, G, Cerana, M, Chiani, C, Chierego, G, Ciani, A, Ciceri, R, Cigada, Mg, Cima, M, Cingolani, E, Cinque, E, Coletta, Rp, Colombo, L, Colombo, R, Converso, M, Corrado, A, Cortis, G, Costagli, V, Crema, L, Crestan, E, Da, D, Cero, Pd, Ferro, Md, De Blasi RA, De Blasio, E, De Cristofaro MG, De Luca, A, Di Pasquale, D, Doroni, L, Fabi, Mc, Facondini, F, Fagoni, Nazzareno, Falzetti, G, Faraldi, L, Fiore, G, Fiume, C, Galeotti, E, Galleschi, N, Gallo, M, Gamberini, E, Garelli, A, Giacomello, S, Gianni, M, Giudici, R, Giuntini, R, Gnesin, P, Gorietti, A, Grassitelli, S, Greco, M, Irpino, A, Guadagna, A, Guadagnucci, A, Guagliardi, C, Laici, C, Lain, G, Lanza, G, Lefons, U, Leggieri, C, Lembo, R, Librenti, M, Liverani, C, Longobardo, A, Madeira, Sm, Madonna, R, Magatti, Mf, Mamprin, F, Mannolini, G, Marafon, S, Marchesi, G, Marifoglou, D, Martinelli, P, Martinelli, S, Escobar, Rm, Mastroianni, A, Mastropierro, R, Mediani, Ts, Messina, M, Milan, B, Molesi, A, Alberto, Cm, Mongelli, P, Morigi, A, Mosti, G, Muttini, S, Nardini, M, Nascimben, E, Natalini, G, Negri, G, Negro, G, Neri, M, Netto, R, Nonini, S, Odetto, L, Olivieri, C, Candida, Mo, Osti, D, Palmer, M, Parnigotto, A, Parrini, V, Pasculli, M, Pasetti, G, Passafiume, M, Pastorini, S, Patrignani, L, Pedeferri, M, Pegoraro, M, Pelati, E, Pelosi, G, Pera, L, Perino, P, Pero, A, Perzolla, D, Peta, M, Pinna, C, Pizzali, M, Postiglione, M, Potalivo, A, Raffaeli, M, Randellini, R, Rech, A, Renda, B, Ricciardi, G, Rizzi, S, Romagnoli, S, Rossi, G, Rossi, M, Rutta, C, Sagliaschi, U, Salcuni, R, Salvi, G, Scalera, M, Scarrone, S, Schiavuzzi, M, Aurelio, Ps, Selvaggi, P, Sicignano, A, Sorbara, C, Spagarino, E, Sparicio, D, Spinazzola, Ar, Sucre, Mj, Terzitta, M, Tetamo, R, Tibaldi, G, Todesco, L, Tomaselli, P, Torta, M, Turriziani, I, Ughi, L, Vaccari, C, Vaj, M, Vanzino, R, Vardanega, A, Vecchiarelli, P, Vedovati, S, Zanni, V, Zappa, S, Zardin, M, Zaro, G, Zuccaro, F, Barattini, M, Chieregato, A, Fumagalli, R, Livigni, S, Mengoli, F, Nardi, G, Palma, D, Portolani, L, Radrizzani, D, Terzitta, M., Bertolini, G, Nattino, G, Langer, M, Tavola, M, Crespi, D, Mondini, M, Rossi, C, Previtali, C, Marshall, J, Poole, D, Abascia, A, Acquarolo, A, Adorni, A, Agnelli, V, Agostini, F, Alampi, D, Alberti, A, Alborghetti, A, Alleva, S, Ambrosoni, S, Antonini, B, Arditi, E, Avalli, L, Babini, M, Bagalini, G, Balata, A, Balicco, B, Barbagallo, M, Bartoli, T, Bassi, G, Becarelli, S, Beck, E, Bellin, M, Bellonzi, A, Bellorini, M, Benanti, C, Bensi, M, Bernasconi, M, Berruto, F, Besozzi, A, Biamino, C, Bianchi, T, Bianchin, A, Boccalatte, D, Bocchi, A, Bonaccorso, G, Bonazzi, M, Balsamo, C, Bonicalzi, V, Boniotti, C, Bonizzoli, M, Bottazzi, A, Breschi, C, Brizio, E, Brunetti, B, Brunori, E, Bubbico, G, Buscaglia, G, Calicchio, G, Calligaro, P, Calva, S, Candido, M, Capitanio, G, Caroleo, S, Casagli, S, Casalini, P, Castiglione, G, Cerana, M, Chiani, C, Chierego, G, Ciani, A, Ciceri, R, Cigada, M, Cima, M, Cingolani, E, Cinque, E, Coletta, R, Colombo, L, Colombo, R, Converso, M, Corrado, A, Cortis, G, Costagli, V, Crema, L, Crestan, E, Da, D, Cero, P, Ferro, M, De Blasi, R, De Blasio, E, De Cristofaro, M, De Luca, A, Di Pasquale, D, Doroni, L, Fabi, M, Facondini, F, Fagoni, N, Falzetti, G, Faraldi, L, Fiore, G, Fiume, C, Galeotti, E, Galleschi, N, Gallo, M, Gamberini, E, Garelli, A, Giacomello, S, Gianni, M, Giudici, R, Giuntini, R, Gnesin, P, Gorietti, A, Grassitelli, S, Greco, M, Irpino, A, Guadagna, A, Guadagnucci, A, Guagliardi, C, Laici, C, Lain, G, Lanza, G, Lefons, U, Leggieri, C, Lembo, R, Librenti, M, Liverani, C, Longobardo, A, Madeira, S, Madonna, R, Magatti, M, Mamprin, F, Mannolini, G, Marafon, S, Marchesi, G, Marifoglou, D, Martinelli, P, Martinelli, S, Escobar, R, Mastroianni, A, Mastropierro, R, Mediani, T, Messina, M, Milan, B, Molesi, A, Alberto, C, Mongelli, P, Morigi, A, Mosti, G, Muttini, S, Nardini, M, Nascimben, E, Natalini, G, Negri, G, Negro, G, Neri, M, Netto, R, Nonini, S, Odetto, L, Olivieri, C, Candida, M, Osti, D, Palmer, M, Parnigotto, A, Parrini, V, Pasculli, M, Pasetti, G, Passafiume, M, Pastorini, S, Patrignani, L, Pedeferri, M, Pegoraro, M, Pelati, E, Pelosi, G, Pera, L, Perino, P, Pero, A, Perzolla, D, Peta, M, Pinna, C, Pizzali, M, Postiglione, M, Potalivo, A, Raffaeli, M, Randellini, R, Rech, A, Renda, B, Ricciardi, G, Rizzi, S, Romagnoli, S, Rossi, G, Rossi, M, Rutta, C, Sagliaschi, U, Salcuni, R, Salvi, G, Scalera, M, Scarrone, S, Schiavuzzi, M, Aurelio, P, Selvaggi, P, Sicignano, A, Sorbara, C, Spagarino, E, Sparicio, D, Spinazzola, A, Sucre, M, Terzitta, M, Tetamo, R, Tibaldi, G, Todesco, L, Tomaselli, P, Torta, M, Turriziani, I, Ughi, L, Vaccari, C, Vaj, M, Vanzino, R, Vardanega, A, Vecchiarelli, P, Vedovati, S, Zanni, V, Zappa, S, Zardin, M, Zaro, G, Zuccaro, F, Barattini, M, Chieregato, A, Fumagalli, R, Livigni, S, Mengoli, F, Nardi, G, Palma, D, Portolani, L, and Radrizzani, D

Subjects
medicine.medical_specialty, Epidemiology, surveillance system, law.invention, 03 medical and health sciences, Influenza A Virus, H1N1 Subtype, 0302 clinical medicine, Public health surveillance, law, Infectious disease epidemiology, influenza, pandemic, Humans, Influenza, Human, Intensive Care Units, Italy, Public Health Surveillance, Pandemics, Pandemic, medicine, human, 030212 general & internal medicine, medicine (all), Intensive care medicine, business.industry, Public health, Outbreak, 030208 emergency & critical care medicine, Monitoring system, medicine.disease, Intensive care unit, infectious disease epidemiology, humans, influenza a virus, h1n1 subtype, intensive care units, italy, public health surveillance, pandemics, infectious diseases, epidemiology, Infectious Diseases, Human mortality from H5N1, Medical emergency, business
Abstract

SUMMARYThe prompt availability of reliable epidemiological information on emerging pandemics is crucial for public health policy-makers. Early in 2013, a possible new H1N1 epidemic notified by an intensive care unit (ICU) to GiViTI, the Italian ICU network, prompted the re-activation of the real-time monitoring system developed during the 2009–2010 pandemic. Based on data from 216 ICUs, we were able to detect and monitor an outbreak of severe H1N1 infection, and to compare the situation with previous years. The timely and correct assessment of the severity of an epidemic can be obtained by investigating ICU admissions, especially when historical comparisons can be made.

Published
2015

14. Workers’ buyout: l’esperienza italiana

Author

Monni, S., Novelli, G., Pera, L., Realini, A., Paola Demartini, salvatore Monni, Monni, S., Novelli, G., Pera, L., and Realini, A.

Subjects
Italia
Published
2017

16. The role of the intensive care unit in real-time surveillance of emerging pandemics: The Italian GiViTI experience

Author

Bertolini, G, Nattino, G, Langer, M, Tavola, M, Crespi, D, Mondini, M, Rossi, C, Previtali, C, Marshall, J, Poole, D, Abascia, A, Acquarolo, A, Adorni, A, Agnelli, V, Agostini, F, Alampi, D, Alberti, A, Alborghetti, A, Alleva, S, Ambrosoni, S, Antonini, B, Arditi, E, Avalli, L, Babini, M, Bagalini, G, Balata, A, Balicco, B, Barbagallo, M, Bartoli, T, Bassi, G, Becarelli, S, Beck, E, Bellin, M, Bellonzi, A, Bellorini, M, Benanti, C, Bensi, M, Bernasconi, M, Berruto, F, Besozzi, A, Biamino, C, Bianchi, T, Bianchin, A, Boccalatte, D, Bocchi, A, Bonaccorso, G, Bonazzi, M, Balsamo, C, Bonicalzi, V, Boniotti, C, Bonizzoli, M, Bottazzi, A, Breschi, C, Brizio, E, Brunetti, B, Brunori, E, Bubbico, G, Buscaglia, G, Calicchio, G, Calligaro, P, Calva, S, Candido, M, Capitanio, G, Caroleo, S, Casagli, S, Casalini, P, Castiglione, G, Cerana, M, Chiani, C, Chierego, G, Ciani, A, Ciceri, R, Cigada, M, Cima, M, Cingolani, E, Cinque, E, Coletta, R, Colombo, L, Colombo, R, Converso, M, Corrado, A, Cortis, G, Costagli, V, Crema, L, Crestan, E, Da, D, Cero, P, Ferro, M, De Blasi, R, De Blasio, E, De Cristofaro, M, De Luca, A, Di Pasquale, D, Doroni, L, Fabi, M, Facondini, F, Fagoni, N, Falzetti, G, Faraldi, L, Fiore, G, Fiume, C, Galeotti, E, Galleschi, N, Gallo, M, Gamberini, E, Garelli, A, Giacomello, S, Gianni, M, Giudici, R, Giuntini, R, Gnesin, P, Gorietti, A, Grassitelli, S, Greco, M, Irpino, A, Guadagna, A, Guadagnucci, A, Guagliardi, C, Laici, C, Lain, G, Lanza, G, Lefons, U, Leggieri, C, Lembo, R, Librenti, M, Liverani, C, Longobardo, A, Madeira, S, Madonna, R, Magatti, M, Mamprin, F, Mannolini, G, Marafon, S, Marchesi, G, Marifoglou, D, Martinelli, P, Martinelli, S, Escobar, R, Mastroianni, A, Mastropierro, R, Mediani, T, Messina, M, Milan, B, Molesi, A, Alberto, C, Mongelli, P, Morigi, A, Mosti, G, Muttini, S, Nardini, M, Nascimben, E, Natalini, G, Negri, G, Negro, G, Neri, M, Netto, R, Nonini, S, Odetto, L, Olivieri, C, Candida, M, Osti, D, Palmer, M, Parnigotto, A, Parrini, V, Pasculli, M, Pasetti, G, Passafiume, M, Pastorini, S, Patrignani, L, Pedeferri, M, Pegoraro, M, Pelati, E, Pelosi, G, Pera, L, Perino, P, Pero, A, Perzolla, D, Peta, M, Pinna, C, Pizzali, M, Postiglione, M, Potalivo, A, Raffaeli, M, Randellini, R, Rech, A, Renda, B, Ricciardi, G, Rizzi, S, Romagnoli, S, Rossi, G, Rossi, M, Rutta, C, Sagliaschi, U, Salcuni, R, Salvi, G, Scalera, M, Scarrone, S, Schiavuzzi, M, Aurelio, P, Selvaggi, P, Sicignano, A, Sorbara, C, Spagarino, E, Sparicio, D, Spinazzola, A, Sucre, M, Terzitta, M, Tetamo, R, Tibaldi, G, Todesco, L, Tomaselli, P, Torta, M, Turriziani, I, Ughi, L, Vaccari, C, Vaj, M, Vanzino, R, Vardanega, A, Vecchiarelli, P, Vedovati, S, Zanni, V, Zappa, S, Zardin, M, Zaro, G, Zuccaro, F, Barattini, M, Chieregato, A, Fumagalli, R, Livigni, S, Mengoli, F, Nardi, G, Palma, D, Portolani, L, Radrizzani, D, Bertolini G., Nattino G., Langer M., Tavola M., Crespi D., Mondini M., Rossi C., Previtali C., Marshall J., Poole D., Abascia A., Acquarolo A., Adorni A., Agnelli V., Agostini F., Alampi D., Alberti A., Alborghetti A., Alleva S., Ambrosoni S., Antonini B., Arditi E., Avalli L., Babini M., Bagalini G., Balata A., Balicco B., Barbagallo M., Bartoli T., Bassi G., Becarelli S., Beck E., Bellin M., Bellonzi A., Bellorini M., Benanti C., Bensi M., Bernasconi M. O., Berruto F., Besozzi A., Biamino C., Bianchi T., Bianchin A., Boccalatte D., Bocchi A., Bonaccorso G., Bonazzi M., Balsamo C., Bonicalzi V., Boniotti C., Bonizzoli M., Bottazzi A., Breschi C., Brizio E., Brunetti B., Brunori E., Bubbico G., Buscaglia G., Calicchio G., Calligaro P., Calva S., Candido M., Capitanio G., Caroleo S., Casagli S., Casalini P., Castiglione G., Cerana M., Chiani C., Chierego G., Ciani A., Ciceri R., Cigada M. G., Cima M., Cingolani E., Cinque E., Coletta R. P., Colombo L., Colombo R., Converso M., Corrado A., Cortis G., Costagli V., Crema L., Crestan E., Da D., Cero P. D., Ferro M. D., De Blasi R. A., De Blasio E., De Cristofaro M. G., De Luca A., Di Pasquale D., Doroni L., Fabi M. C., Facondini F., Fagoni N., Falzetti G., Faraldi L., Fiore G., Fiume C., Galeotti E., Galleschi N., Gallo M., Gamberini E., Garelli A., Giacomello S., Gianni M., Giudici R., Giuntini R., Gnesin P., Gorietti A., Grassitelli S., Greco M., Irpino A., Guadagna A., Guadagnucci A., Guagliardi C., Laici C., Lain G., Lanza G., Lefons U., Leggieri C., Lembo R., Librenti M., Liverani C., Longobardo A., Madeira S. M., Madonna R., Magatti M. F., Mamprin F., Mannolini G., Marafon S., Marchesi G., Marifoglou D., Martinelli P., Martinelli S., Escobar R. M., Mastroianni A., Mastropierro R., Mediani T. S., Messina M., Milan B., Molesi A., Alberto C. M., Mongelli P., Morigi A., Mosti G., Muttini S., Nardini M., Nascimben E., Natalini G., Negri G., Negro G., Neri M., Netto R., Nonini S., Odetto L., Olivieri C., Candida M. O., Osti D., Palmer M., Parnigotto A., Parrini V., Pasculli M., Pasetti G., Passafiume M., Pastorini S., Patrignani L., Pedeferri M., Pegoraro M., Pelati E., Pelosi G., Pera L., Perino P., Pero A., Perzolla D., Peta M., Pinna C., Pizzali M., Postiglione M., Potalivo A., Raffaeli M., Randellini R., Rech A., Renda B., Ricciardi G., Rizzi S., Romagnoli S., Rossi G., Rossi M., Rutta C., Sagliaschi U., Salcuni R., Salvi G., Scalera M., Scarrone S., Schiavuzzi M., Aurelio P. S., Selvaggi P., Sicignano A., Sorbara C., Spagarino E., Sparicio D., Spinazzola A. R., Sucre M. J., Terzitta M., Tetamo R., Tibaldi G., Todesco L., Tomaselli P., Torta M., Turriziani I., Ughi L., Vaccari C., Vaj M., Vanzino R., Vardanega A., Vecchiarelli P., Vedovati S., Zanni V., Zappa S., Zardin M., Zaro G., Zuccaro F., Barattini M., Chieregato A., Fumagalli R., Livigni S., Mengoli F., Nardi G., Palma D., Portolani L., Radrizzani D., Bertolini, G, Nattino, G, Langer, M, Tavola, M, Crespi, D, Mondini, M, Rossi, C, Previtali, C, Marshall, J, Poole, D, Abascia, A, Acquarolo, A, Adorni, A, Agnelli, V, Agostini, F, Alampi, D, Alberti, A, Alborghetti, A, Alleva, S, Ambrosoni, S, Antonini, B, Arditi, E, Avalli, L, Babini, M, Bagalini, G, Balata, A, Balicco, B, Barbagallo, M, Bartoli, T, Bassi, G, Becarelli, S, Beck, E, Bellin, M, Bellonzi, A, Bellorini, M, Benanti, C, Bensi, M, Bernasconi, M, Berruto, F, Besozzi, A, Biamino, C, Bianchi, T, Bianchin, A, Boccalatte, D, Bocchi, A, Bonaccorso, G, Bonazzi, M, Balsamo, C, Bonicalzi, V, Boniotti, C, Bonizzoli, M, Bottazzi, A, Breschi, C, Brizio, E, Brunetti, B, Brunori, E, Bubbico, G, Buscaglia, G, Calicchio, G, Calligaro, P, Calva, S, Candido, M, Capitanio, G, Caroleo, S, Casagli, S, Casalini, P, Castiglione, G, Cerana, M, Chiani, C, Chierego, G, Ciani, A, Ciceri, R, Cigada, M, Cima, M, Cingolani, E, Cinque, E, Coletta, R, Colombo, L, Colombo, R, Converso, M, Corrado, A, Cortis, G, Costagli, V, Crema, L, Crestan, E, Da, D, Cero, P, Ferro, M, De Blasi, R, De Blasio, E, De Cristofaro, M, De Luca, A, Di Pasquale, D, Doroni, L, Fabi, M, Facondini, F, Fagoni, N, Falzetti, G, Faraldi, L, Fiore, G, Fiume, C, Galeotti, E, Galleschi, N, Gallo, M, Gamberini, E, Garelli, A, Giacomello, S, Gianni, M, Giudici, R, Giuntini, R, Gnesin, P, Gorietti, A, Grassitelli, S, Greco, M, Irpino, A, Guadagna, A, Guadagnucci, A, Guagliardi, C, Laici, C, Lain, G, Lanza, G, Lefons, U, Leggieri, C, Lembo, R, Librenti, M, Liverani, C, Longobardo, A, Madeira, S, Madonna, R, Magatti, M, Mamprin, F, Mannolini, G, Marafon, S, Marchesi, G, Marifoglou, D, Martinelli, P, Martinelli, S, Escobar, R, Mastroianni, A, Mastropierro, R, Mediani, T, Messina, M, Milan, B, Molesi, A, Alberto, C, Mongelli, P, Morigi, A, Mosti, G, Muttini, S, Nardini, M, Nascimben, E, Natalini, G, Negri, G, Negro, G, Neri, M, Netto, R, Nonini, S, Odetto, L, Olivieri, C, Candida, M, Osti, D, Palmer, M, Parnigotto, A, Parrini, V, Pasculli, M, Pasetti, G, Passafiume, M, Pastorini, S, Patrignani, L, Pedeferri, M, Pegoraro, M, Pelati, E, Pelosi, G, Pera, L, Perino, P, Pero, A, Perzolla, D, Peta, M, Pinna, C, Pizzali, M, Postiglione, M, Potalivo, A, Raffaeli, M, Randellini, R, Rech, A, Renda, B, Ricciardi, G, Rizzi, S, Romagnoli, S, Rossi, G, Rossi, M, Rutta, C, Sagliaschi, U, Salcuni, R, Salvi, G, Scalera, M, Scarrone, S, Schiavuzzi, M, Aurelio, P, Selvaggi, P, Sicignano, A, Sorbara, C, Spagarino, E, Sparicio, D, Spinazzola, A, Sucre, M, Terzitta, M, Tetamo, R, Tibaldi, G, Todesco, L, Tomaselli, P, Torta, M, Turriziani, I, Ughi, L, Vaccari, C, Vaj, M, Vanzino, R, Vardanega, A, Vecchiarelli, P, Vedovati, S, Zanni, V, Zappa, S, Zardin, M, Zaro, G, Zuccaro, F, Barattini, M, Chieregato, A, Fumagalli, R, Livigni, S, Mengoli, F, Nardi, G, Palma, D, Portolani, L, Radrizzani, D, Bertolini G., Nattino G., Langer M., Tavola M., Crespi D., Mondini M., Rossi C., Previtali C., Marshall J., Poole D., Abascia A., Acquarolo A., Adorni A., Agnelli V., Agostini F., Alampi D., Alberti A., Alborghetti A., Alleva S., Ambrosoni S., Antonini B., Arditi E., Avalli L., Babini M., Bagalini G., Balata A., Balicco B., Barbagallo M., Bartoli T., Bassi G., Becarelli S., Beck E., Bellin M., Bellonzi A., Bellorini M., Benanti C., Bensi M., Bernasconi M. O., Berruto F., Besozzi A., Biamino C., Bianchi T., Bianchin A., Boccalatte D., Bocchi A., Bonaccorso G., Bonazzi M., Balsamo C., Bonicalzi V., Boniotti C., Bonizzoli M., Bottazzi A., Breschi C., Brizio E., Brunetti B., Brunori E., Bubbico G., Buscaglia G., Calicchio G., Calligaro P., Calva S., Candido M., Capitanio G., Caroleo S., Casagli S., Casalini P., Castiglione G., Cerana M., Chiani C., Chierego G., Ciani A., Ciceri R., Cigada M. G., Cima M., Cingolani E., Cinque E., Coletta R. P., Colombo L., Colombo R., Converso M., Corrado A., Cortis G., Costagli V., Crema L., Crestan E., Da D., Cero P. D., Ferro M. D., De Blasi R. A., De Blasio E., De Cristofaro M. G., De Luca A., Di Pasquale D., Doroni L., Fabi M. C., Facondini F., Fagoni N., Falzetti G., Faraldi L., Fiore G., Fiume C., Galeotti E., Galleschi N., Gallo M., Gamberini E., Garelli A., Giacomello S., Gianni M., Giudici R., Giuntini R., Gnesin P., Gorietti A., Grassitelli S., Greco M., Irpino A., Guadagna A., Guadagnucci A., Guagliardi C., Laici C., Lain G., Lanza G., Lefons U., Leggieri C., Lembo R., Librenti M., Liverani C., Longobardo A., Madeira S. M., Madonna R., Magatti M. F., Mamprin F., Mannolini G., Marafon S., Marchesi G., Marifoglou D., Martinelli P., Martinelli S., Escobar R. M., Mastroianni A., Mastropierro R., Mediani T. S., Messina M., Milan B., Molesi A., Alberto C. M., Mongelli P., Morigi A., Mosti G., Muttini S., Nardini M., Nascimben E., Natalini G., Negri G., Negro G., Neri M., Netto R., Nonini S., Odetto L., Olivieri C., Candida M. O., Osti D., Palmer M., Parnigotto A., Parrini V., Pasculli M., Pasetti G., Passafiume M., Pastorini S., Patrignani L., Pedeferri M., Pegoraro M., Pelati E., Pelosi G., Pera L., Perino P., Pero A., Perzolla D., Peta M., Pinna C., Pizzali M., Postiglione M., Potalivo A., Raffaeli M., Randellini R., Rech A., Renda B., Ricciardi G., Rizzi S., Romagnoli S., Rossi G., Rossi M., Rutta C., Sagliaschi U., Salcuni R., Salvi G., Scalera M., Scarrone S., Schiavuzzi M., Aurelio P. S., Selvaggi P., Sicignano A., Sorbara C., Spagarino E., Sparicio D., Spinazzola A. R., Sucre M. J., Terzitta M., Tetamo R., Tibaldi G., Todesco L., Tomaselli P., Torta M., Turriziani I., Ughi L., Vaccari C., Vaj M., Vanzino R., Vardanega A., Vecchiarelli P., Vedovati S., Zanni V., Zappa S., Zardin M., Zaro G., Zuccaro F., Barattini M., Chieregato A., Fumagalli R., Livigni S., Mengoli F., Nardi G., Palma D., Portolani L., and Radrizzani D.

Abstract

The prompt availability of reliable epidemiological information on emerging pandemics is crucial for public health policy-makers. Early in 2013, a possible new H1N1 epidemic notified by an intensive care unit (ICU) to GiViTI, the Italian ICU network, prompted the re-activation of the real-time monitoring system developed during the 2009-2010 pandemic. Based on data from 216 ICUs, we were able to detect and monitor an outbreak of severe H1N1 infection, and to compare the situation with previous years. The timely and correct assessment of the severity of an epidemic can be obtained by investigating ICU admissions, especially when historical comparisons can be made.

Published
2016

18. Foxm1 controls a pro-stemness microRNA network in neural stem cells

Author

Besharat, Z. M., Abballe, L., Cicconardi, F., Bhutkar, A., Grassi, L., Le Pera, L., Moretti, M., Chinappi, M., D'Andrea, D., Mastronuzzi, A., Ianari, A., Vacca, A., De Smaele, E., Locatelli, Franco, Po, A., Miele, E., Ferretti, E., Locatelli F. (ORCID:0000-0002-7976-3654), Besharat, Z. M., Abballe, L., Cicconardi, F., Bhutkar, A., Grassi, L., Le Pera, L., Moretti, M., Chinappi, M., D'Andrea, D., Mastronuzzi, A., Ianari, A., Vacca, A., De Smaele, E., Locatelli, Franco, Po, A., Miele, E., Ferretti, E., and Locatelli F. (ORCID:0000-0002-7976-3654)

Abstract

Cerebellar neural stem cells (NSCs) require Hedgehog-Gli (Hh-Gli) signalling for their maintenance and Nanog expression for their self-renewal. To identify novel molecular features of this regulatory pathway, we used next-generation sequencing technology to profile mRNA and microRNA expression in cerebellar NSCs, before and after induced differentiation (Diff-NSCs). Genes with higher transcript levels in NSCs (vs. Diff-NSCs) included Foxm1, which proved to be directly regulated by Gli and Nanog. Foxm1 in turn regulated several microRNAs that were overexpressed in NSCs: miR-130b, miR-301a, and members of the miR-15∼16 and miR-17∼92 clusters and whose knockdown significantly impaired the neurosphere formation ability. Our results reveal a novel Hh-Gli-Nanog-driven Foxm1-microRNA network that controls the self-renewal capacity of NSCs.

Published
2018

19. The prognostic importance of chronic end-stage diseases in geriatric patients admitted to 163 Italian ICUs

Author

Poole, D., Finazzi, S., Nattino, G., Radrizzani, D., Gristina, G., Malacarne, P., Livigni, S., Bertolini, G., Sorgato, C., Mannoni, R., Agnelli, V., Chiani, C., Lanza, G., Venturini, E., Gianni, M., Olivieri, M. C., Guerriero, B., Della Mora, E., Palmer, M., Blasetti, A., Coletta, R., Covani Frigieri, F., Guarducci, M. D., Caracciolo, A., Lain, G., Bernard, M., DE Blasio, E., Zanni, V., Marchesi, G., Madeira, S. M., Spagarino, E., Potalivo, A., Mengoli, F., Parrini, V., Sagliaschi, U., Prandini, A., Rosano, A., Natalini, G., Piccioni, G., Schiavuzzi, M., Bronzini, N., Piva, S., Besozzi, A., Napoleone, A., Patrignani, L., Pisu, M., Mancosu, S., Chiarello, M., Pastorini, S., Bassi, G., Negro, G., Orsini, I., Marifoglou, D., Pota, V., Pegoraro, M., Sucre, M. J., DI Masi, P., Castiglione, G., Morello, G., Garofalo, G., Caroleo, S., Visconti, M. G., Gamberini, E., Mastroianni, A., Liccardi, M. M., Anelati, D., Martinelli, S., Bonato, A., Adorni, A., Colombo, D., Dal Cero, P., Crema, L., Petrucci, N., Beck, E., Alleva, S., Giuntini, R., DA Re, D., Casalini, P., Fabi, M. C., Galeotti, E., Bagalini, G., Bellonzi, A., Zoppellari, R., Lamborghini, S., Pera, L., Doni, L., Bonizzoli, M., Librenti, M., Barattini, M., Mangani, V., Terzitta, M., Guagliardi, C., Bruzzone, C., Arditi, E., Cerana, M., Tavola, M., Falini, S., Vespignani, M. G., Salvi, G., Ramello, P. L., Molesi, A., Ceradelli, M., Buonanno, R., Righini, E., DI Cocco, A., DI Martino, R., Cinque, E., Bonfiglio, M., Ciceri, R., Colombo, L., Nardini, M., Rossi, G., Boccalatte-Rosa, D. L., Babini, M., Zompanti, V., Negri, G., Antonini, B., Baratta, A., Zuccaro, F., Rossi, M., Pedeferri, M., Bellin, M., Sicignano, A., Pezzi, A., Leggieri, C., Fontana, G., Faraldi, L., Cigada, M. G., Magenta, P., Colombo, R., Colombo, S., Gonzi, S., Pizzali, M., Girardis, M., Piccinini, P., Bignone, P., Padovan, L., Bianchin, A., Caria, F. C., Randellini, R., Roticiani, V., Grassi, M., Belluomo Anello, C., Decristofaro, M., Postiglione, M., Giacomello, S., Olivieri, C., Vaccari, C., Dal Ferro, M., Messina, M., Belgiorno, N., Odetto, L., Pasetti, G. S., Balicco, B., Pizzaballa, M. L., Muraro, L., Pignataro, A., Guadagna, A., Fabbri, P. G., Tetamo, R., Bottazzi, A., Mediani, T. S., Gorietti, A., Breschi, C., Ciani, A., Segalini, P., Codeluppi, V., Berruto, F., Pastorelli, M., Comite, C., Pelati, E., Bertolini, R., Lefons, U., DI Pasquale, D. A., Mannolini, G., Vlassich, F., Becarelli, S., Garelli, A., Salsi, P., Rossi, S., Facondini, F., Alampi, D., Cingolani, E., Molino, F. M., Nardi, G., Casula, M., DE Blasi, R. A., Vulcano, G. A., Azzolini, M., Bernasconi, M. O., Bellato, V., Calicchio, G., Righetti, F., Turati, M., Dei Poli, M., Zaro, G., Brizio, E., Coaloa, M., Falzetti, G., Mamprin, F., Liverani, C. M., Clementi, S., Bonucci, P., Varesio, V., Pannacci, R., Fiore, G., Gallo, M., Torta, M., Selvaggi, P., Bert, P. P., Segala, V., Pettazzi, G., Bensi, M., Bocchi, A., Cima, M., Morbelli, M., Peta, M., DI Stella, R., Maggiolo, C., Lembo, R., Pero, A., Marafon, S., Carnevale, L., Vanzino, R., Vecchiarelli, P., and Marino, G.

Subjects
Male, medicine.medical_specialty, Cirrhosis, Disease, Severity of Illness Index, law.invention, 03 medical and health sciences, 0302 clinical medicine, Patient Admission, Postoperative Complications, law, Internal medicine, 80 and over, aged, critical care, prognosis, Medicine, Dementia, Humans, Hospital Mortality, Elective surgery, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Critical care, Prognosis, Female, Intensive Care Units, Italy, Chronic Disease, 030208 emergency & critical care medicine, Odds ratio, medicine.disease, Comorbidity, Intensive care unit, Anesthesiology and Pain Medicine, 030228 respiratory system, Cohort, business
Abstract

BACKGROUND The number of elderly patients undergoing major surgical interventions and then needing admission to intensive care unit (ICU) grows steadily. We investigated this issue in a cohort of 232,278 patients admitted in five years (2011-2015) to 163 Italian general ICUs. METHODS Surgical patients older than 75 registered in the GiViTI MargheritaPROSAFE project were analyzed. The impact on hospital mortality of important chronic conditions (severe COPD, NYHA class IV, dementia, end-stage renal disease, cirrhosis with portal hypertension) was investigated with two prognostic models developed yearly on patients staying in the ICU less or more than 24 hours. RESULTS 44,551 elderly patients (19.2%) underwent emergency (47.3%) or elective surgery (52.7%). At least one severe comorbidity was present in 14.6% of them, yielding a higher hospital mortality (32.4%, vs. 21.1% without severe comorbidity). In the models for patients staying in the ICU 24 hours or more, cirrhosis, NYHA class IV, and severe COPD were constant independent predictors of death (adjusted odds ratios [ORs] range 1.67-1.97, 1.54-1.91, and 1.34-1.50, respectively), while dementia was statistically significant in four out of five models (adjusted ORs 1.23-1.28). End-stage renal disease, instead, never resulted to be an independent prognostic factor. For patients staying in the ICU less than 24 hours, chronic comorbidities were only occasionally independent predictors of death. CONCLUSIONS Our study confirms that elderly surgical patients represent a relevant part of all ICUs admissions. About one of seven bear at least one severe chronic comorbidity, that, excluding end-stage renal disease, are all strong independent predictors of hospital death.

Published
2017

20. Results and Perspectives of the Auger Engineering Radio Array

Author

Glaser, Jens Christian, Pierre Auger Collaboration, Almela, A., Diogo, F., Dobrigkeit, C., Dorofeev, A., Dova, M. T., Dundovic, A., Suarez Durán, M., Ebr, J., Torralba Elipe, G., Enge, R., Erdmann, Martin, Alvarez-Muñiz, J., Erfani, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Falcke, H., Fang, K., Farrar, G., Fauth, A. C., Fazzini, N., Rodriguez Fernandez, G., Ambrosio, M., Fick, B., Figueira, J. M., Filevich, A., Filipčič, A., Fratu, O., Freire, M. M., Fujii, T., Fuster, A., Głas, D., Valdés Galicia, J. F., Anastasi, G. A., Garcia-Pinto, D., García, B., Gaté, F., Gemmeke, H., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Giulio, C. Di, Anchordoqui, L., Glass, H., Golup, G., Sanabria Gomez, J. D., González, N., Gookin, B., Gordon, J., Gorgi, A., Gorham, P., Gouffon, P., Andrada, B., Salesa Greus, F., Grillo, A. F., Grubb, T. D., Guarino, F., Guedes, G. P., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Harton, J. L., Andringa, S., Hasankiadeh, Q., Haungs, A., Hebbeker, Thomas, Heck, D., Heimann, P., Herve, A. E., Hill, G. C., Hojvat, C., Holt, E., Homola, P., dos Anjos, R. C., Horvath, P., Hrabovský, M., Huege, T., Hulsman, J., Hörandel, J. R., Insolia, A., Isar, P. G., Jandt, I., Jansen, S., Johnsen, J. A., Aramo, C., de Jong, S. J., Josebachuili, M., Kambeitz, O., Kampert, K. H., Kasper, P., Katkov, I., Keilhauer, B., Kemp, E., Kieckhafer, R. M., Klages, H. O., Arqueros, F., Kleifges, M., Kleinfeller, J., Krause, Raphael, Krohm, N., Kümpel, Daniel, Kunka, N., Kääpä, A., LaHurd, D., Latronico, L., Lauscher, Markus, Aab, A., Arsene, N., Lautridou, P., Lebrun, P., Legumina, R., Letessier-Selvon, A., Lhenry-Yvon, I., Link, K., Lopes, L., Luce, Q., Lucero, A., López, R., Asorey, H., Torres Machado, D., Malacari, M., Mallamaci, M., Mandat, D., Mantsch, P., Mariş, I. C., Mariazzi, A. G., Marsella, G., Martello, D., Martinez, H., Assis, P., Mathes, H. J., Mathys, S., Matteo, A. Di, Matthews, J., Matthews, J. A. J., Matthiae, G., De Mauro, G., Mayotte, E., Mazur, P. O., Medina, C., Aublin, J., Medina-Tanco, G., Melo, D., Menshikov, A., Messina, S., Masías Meza, J. J., Kukec Mezek, G., Micheletti, M. I., Middendorf, Lukas, Minaya, I. A., Miramonti, L., Avila, G., De Mitri, I., Mitrica, B., Mockler, D., Molina-Bueno, L., Mollerach, S., Montanet, F., Morello, C., Mostafá, M., Muller, M. A., Müller, Gero, Kuotb Awad, A. M., Müller, S., Naranjo, I., Navas, S., Nellen, L., de Mello Neto, J. R. T., Neuser, J., Nguyen, P. H., Niculescu-Oglinzanu, M., Niechciol, M., Niemietz, L., Badescu, A. M., Niggemann, Tim, Nitz, D., Nosek, D., Novotny, V., Nožka, H., Núñez, L. A., Ochilo, L., Oikonomou, F., Olinto, A., de Oliveira, J., Balaceanu, A., Leigui de Oliveira, M. A., Pękala, J., Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Paul, T., Pech, M., Pedreira, F., Baus, C., Todero Peixoto, C. J., Pelayo, R., Pera, L. del, Pereira, L. A. S., Perrone, L., Peters, Christine, Petrera, S., Peña-Rodriguez, J., Phuntsok, J., Piegaia, R., Beatty, J. J., Pierog, T., Pieroni, P., Pimenta, M., Pirronello, V., Platino, M., Plum, Matthias, Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Abreu, P., Becker, K. H., Quel, E. J., Querchfeld, S., Quinn, S., Ramos-Pollant, R., Rautenberg, J., Ravel, O., Ravignani, D., Reinert, Darius, Revenu, B., Ridky, J., Bellido, J. A., Risse, M., Ristori, P., Rizi, V., Rodríguez-Frías, M. D., Rogozin, D., Rodriguez Rojo, J., Rosado, J., Roth, M., Roulet, E., Rovero, A. C., Berat, C., Saffi, S. J., Saftoiu, A., Salazar, H., Saleh, A., Salina, G., Al Samarai, I., Sanchez-Lucas, P., Santos, E., Santos, E. M., Sarazin, F., van den Berg, A. M., Sarkar, B., Sarmento, R., Sarmiento-Cano, C., Sato, R., Scarso, C., Schauer, M., Scherini, V., Schieler, H., Schmidt, D., Scholten, O., Gómez Berisso, M., Schovánek, P., Schröder, F. G., Schulz, A., Schulz, J., Schumacher, Johannes, Sciutto, S. J., Segreto, A., Pakk Selmi-Dei, D., Settimo, M., Shadkam, A., Bertaina, M. E., Shellard, R. C., Sigl, G., Silli, G., Sima, O., Śmiałkowski, A., Šmída, R., Snow, G. R., Sommers, P., Sonntag, S., Sorokin, J., Bertou, X., de Souza, V., Squartini, R., Stanca, D., Stanič, S., Stasielak, J., Strafella, F., Suarez, F., Sudholz1, T., Suomijärvi, T., Supanitsky, A. D., Biermann, P. L., Sutherland, M. S., Swain, J., Szadkowski, Z., Sánchez, F., Taborda, O. A., Tapia, A., Tepe, A., Theodoro, V. M., Timmermans, C., Tomankova, L., Billoir, P., Tomé, B., Tonachini, A., Torri, M., Travnicek, P., Trini, M., Ulrich, R., Unger, M., Urban, Martin, Valbuena-Delgado, A., Valiño, I., Biteau, J., Valore, L., van Aar, G., Varela, E., Varner, G., Veberič, D., Verzi, V., Vicha, J., Villaseñor, L., Gómez Vitale, P. F., van Vliet, A., Aglietta, M., Blaess, S. G., Vorobiov, S., Vázquez, J. R., Vázquez, R. A., Wahlberg, H., Wainberg, O., Walz, David Simon, Watsona, A. A., Weber, M., Weindl, A., Wiencke, L., Blanco, A., Wilczyński, H., Winchen, T., Wittkowski, D., Wundheiler, B., Wykes, S., Yang, L., Yelos, D., Yushkov, A., Zas, E., Zavrtanik, D., Blazek, J., Zavrtanik, M., Zepeda, A., Zimmermann, B., Ziolkowski, M., Zong, Z., Zuccarello, F., Bleve, C., van Bodegom, P., Boháčová, M., Boncioli, D., Bonifazi, C., Borodai, N., Botti, A. M., Ahn, E. J., Brack, J., Brancus, I., Martínez Bravo, O., Bretz, Thomas, Bridgeman, A., Briechle, Florian Lukas, Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Albuquerque, I. F. M., Caballero-Mora, K. S., Caccianiga, B., Caccianiga, L., Cancio, A., Canfora, F., Caramete, L., Caruso, R., Rodrigues de Carvalho, W., López Casado, Aida, Castellina, A., Allekotte, I., Alvarez Castillo, J., Díaz Castro, M. L., Cataldi, G., Cazon, L., Cester, R., Chavez, A. G., Chiavassa, A., Chinellato, J. A., Chudoba, J., Clay, R. W., Allison, P., Colalillo, R., Coleman, A., Collica, L., Coluccia, M. R., Conceição, R., Contreras, F., Cooper, M. J., Coutu, S., Covault, C. E., Cronin, J., de Almeida, R. M., Vargas Cárdenas, B., D'Amico, S., D'Olivo, J. C., Dalliere, R., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., Debatin, J., and Deligny, O.

Subjects
radio wave, showers: atmosphere, air, detector: surface, engineering, cosmic radiation: energy, calibration, Auger, observatory, energy [cosmic radiation], surface [detector], site, ddc:530, energy [radiation], radiation: energy, atmosphere [showers], experimental results
Abstract

7th International Conference on Acoustic and Radio EeV Neutrino Detection Activities (ARENA 2016) : Groningen, The Netherlands, June 7-10, 2016 / S. Buitink, J.R. Hörandel, S. de Jong, R. Lahmann, R. Nahnhauer and O. Scholten (eds.) 7th International Conference on Acoustic and Radio EeV Neutrino Detection Activities, ARENA, Groningen, Netherlands, 7 Jun 2016 - 10 Jun 2016; Les Ulis : EDP Sciences, The European physical journal. Web of Conferences, 135, 01006, 1-5 (2017). doi:10.1051/epjconf/201713501006, Published by EDP Sciences, Les Ulis

Published
2017
Full Text
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22. Characterization of Sicilian virgin olive oils. Note X. A comparison between Cerasuola and Nocellara del BeliceUn noventa por ciento de los olivos de la cuenca mediterránea son destinados a la producción de aceite. Dentro de un amplio es varieties

Author

Pizzimenti, G., Maisano, R., Pollicino, D., Mavrogeni, E., La Pera, L., Alfa, M., and Dugo, G.mo

Subjects
Characterization, Variety, lcsh:TX341-641, Quality, Caracterización, lcsh:Nutrition. Foods and food supply, Olive oil, Aceite de oliva, Calidad, Variedad
Abstract

Ninety percent of the olive trees are destined to oil production in the Mediterranean basin. Within a wide study of Southern Italian olive oils, with a particular reference to Sicily, several varieties of olive have been studied. The result of an analytical study carried out with two cultivars "Nocellara del Belice" and "Cerasuola" for six consecutive years is described in this paper. Parameters related to olive oil purity and shelf-life together with the composition (%) of sterols and fatty acids of the single oils are shown. Data were analyzed by the univariate non-parametric Mann-Whitney test and the multivariate procedure of Factor Analysis.Un noventa por ciento de los olivos de la cuenca mediterránea son destinados a la producción de aceite. Dentro de un amplio estudio de los aceites de oliva del sur de Italia, con especial atención a Sicilia, se han estudiado distintas variedades de olivos. El resultado de un estudio analítico llevado a cabo con dos cultivares "Nocellara del Belice" y "Cerasuola" es descrito en este trabajo. Se muestran distintos parámetros relacionados con la pureza del aceite y la estabilidad junto con la composición (%) esterólica y de ácidos grasos de los ácidos individuales. Los datas obtenidos se analizan tanto por métodos paramétricos univariantes (test de Mann-Whitney) como por procedimientos multivariantes de análisis factorial.

Published
2004

24. Analysis of furan in toasted coffee by HS/SPME-GC-MS

Author

FANARA, Serena, AGOZZINO, Pasquale, AVELLONE, Giuseppe, LA PERA L, DUGO GMO, FANARA S, AGOZZINO P, AVELLONE G, LA PERA L, and DUGO GMO

Subjects
Furan, coffee,HS/SPME-GC-MS, Settore CHIM/10 - Chimica Degli Alimenti
Published
2008

28. Investigaciones bioarqueológicas en la laguna Chadilauquen, Embajador Martini, departamento Realicó, provincia de La Pampa: segunda etapa

Author

Mendonça, Osvaldo Juan, Aguerre, Ana M., Arrieta, Mario A., and Pera, L. M.

Subjects
Antropología, deformación anular, bioarqueología, Holoceno, Isótopos, La Pampa (Argentina), Arqueología
Abstract

Se presentan los resultados obtenidos a partir del análisis de evidencia arqueológica recuperada desde 1989 durante trabajos arqueológicos y bioarqueológicos en la laguna Chadilauquen, a 5 km al SE de Embajador Martini, depto. de Realicó, prov. de La Pampa. El objetivo de esta segunda etapa fue aportar información relacionada con nuevos materiales expuestos por la acción de agentes erosivos y evaluarlos conjuntamente con aquellos obtenidos en campañas anteriores. Los nuevos hallazgos fueron encontrados en posición topológica similar a los recuperados entre 1989 y 1994. Se analizaron factores post-depósito para proporcionar una caracterización más ajustada sobre los procesos de formación del lugar y del fenómeno de remoción sedimentaria observado sobre la margen NE de la laguna. En abril de 2003, mediando invitación expresa del Municipio, se renovaron los trabajos en la laguna. Recién en el año 2005 se dieron las condiciones climáticas adecuadas que, junto con el necesario descenso de las aguas, posibilitaron la continuación de los trabajos sistemáticos. En el año 2009, se obtuvieron muestras de materiales óseos y dentales a fin de realizar sobre ellos tanto dataciones por AMS (Universidad de Arizona) como análisis químicos (Universidad de Arizona y Universidad de South Florida). Los resultados sugieren la existencia de al menos dos eventos de ocupación potencialmente verificables en diferentes niveles estratigráficos. Se discuten posibles diferencias cronológicas a lo largo del Holoceno y la existencia de variaciones temporales y culturales dentro de un patrón isotópico general de tipo C3., In this paper we present the results of the analysis of archaeological evidence recovered since 1989 during different archaeological and bioarchaeological fieldworks at Chadilauquen lagoon, located about five km SE from the town of Embajador Martini (Realicó district, La Pampa Province, Argentina). The aim of this second stage was to contribute with new information obtained from new naturally exposed archaeological evidence and to compare and evaluate it with the information obtained in previous fieldworks. Post deposit factors were analyzed to provide a more accurate characterization on the formation processes that took place and determined the distribution of findings as well as the sedimentary removal phenomenon observed at the NE margin of the lagoon. The new findings were found in a similar topologic position than those recovered between 1989 and 1994. On April 2003, due to a formal invitation from the County authorities, the works at the lagoon were renewed. In the year 2005 adequate climatic conditions as well as the decrease of water level made possible to continue systematic research at the place. In 2009, bone and dental samples were obtained for AMS dating and sent to the University of Arizona. Several chemical analyses were performed at the University of Arizona as well as at the University of South Florida. Results suggest the existence of different episodes of human occupation potentially verifiable at least from two stratigraphic levels. Possible chronologic differences throughout the Holocene and the existence of chronologic as well as cultural variation in a general isotopic C3 pattern are discussed., Facultad de Ciencias Naturales y Museo

Published
2013

31. METALLI PESANTI NEL VINO

Author

LA PERA, L., Rando, Rossana, LO TURCO, Vincenzo, DI BELLA, Giuseppa, and Dugo, Giacomo

Published
2011

32. AROMI DEL VINO

Author

LO TURCO, Vincenzo, Pollicino, Donatella, LA PERA, L., Amirante, P., Tamborrino, A., and Dugo, Giacomo

Published
2011

34. CONTAMINANTI DEL VINO

Author

LA PERA, L., DI BELLA, Giuseppa, LO TURCO, Vincenzo, Saitta, Marcello, and Dugo, Giacomo

Published
2011

43. AEIOP PROTOCOL RB 05: AD INTERIM ANALYSIS ON 31/5/2008

Author

Acquaviva, A, LE PERA, L, Cozza, R, Hadjistilianou, T, DE FRANCESCO, S, Bomarzo, A, Petris, Mg, Midena, Edoardo, Donfrancesco, A, Garre, Ml, Priolo, G, Pession, A, Burnellli, R, Tamburini, A, D'Amico, S, Reibaldi, A, Santoro, N, Scarsello, G, Indolfi, P, and Balistreri, A.

Published
2008

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