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Monitoring structural stability in urban areas and infrastructure networks is emerging as one of the dominant socio-economic issues for population security. The problem is accentuated by the age of the infrastructure because of increasing risks due to material deterioration and loss of load capacity. In this case, SAR satellite data are crucial to identify and assess the deteriorating conditions of civil infrastructures. The large amount of data available from SAR satellite sensors leads to the exploitation and development of new GIS-based procedures for rapid responses and decision making. In recent decades, the DInSAR technique has been used efficiently for the monitoring of structures, providing measurement points located on structures with millimeter precision. Our study has analyzed the behavior of structures in settlements, attempting to discuss the interactions of soil and structures, and examining the behavior of different types of structures, such as roads and buildings. The method used is based on long-term SAR interferometry data and a semi-automatic procedure to measure the displacement (mm/year) of structures, through a GIS-based application performed in the “Implemented MOnitoring DIsplacement” I.MODI platform. The analysis provides extensive information on long-term spatial and temporal continuity of up to 25 years of record, using satellite SAR multi-sensors from ERS, Envisat, and COSMO-SkyMed. The interpretation uses time series spatial analysis, supported by orthophotos, and layers of the DBTR (regional topographic database), Digital Surface model (DSM), and hydrogeological map to show anomalous areas with a high displacement rate and to observe the correlation of settlements in the sediments. With the satellite information and Geographic Information System (GIS), we were able to observe relevant parameters, such as the velocity of advance in the direction of the slope (deformation profiles), the cumulative displacement, and the trend changes in structures. The results illustrate an innovative procedure that allows the management of DInSAR data to facilitate the effective management of structures in which a monitoring protocol was developed at different spatial scales, integrating the information into a GIS.

In the absence of systematic structural monitoring to support adequate maintenance standards, many existing infrastructures may reach unacceptable quality levels during their life cycle, resulting in significant damage and even potential failure. The metropolitan area of the Gulf of Salerno (Italy), served by a complex multimodal transport network connecting the port area to the roads and railways surrounding the urban area, represents an important industrial and commercial hub at the local and international scale. This particular scenario, developed in a complex morphological and geological context, has led to the interference and overlapping of the transport network (highway, railway, main and secondary roads) that run through the piedmont area north of the port. Given the relevance of the area, our research aims to highlight the capabilities of the persistent scatterer interferometry (PSI) technique, belonging to the group of differential interferometric synthetic aperture radar (SAR), to extract space–temporal series of displacements on ground points or artifacts with millimeter accuracy useful to understand ongoing deformation processes. By using archived data from the European Space Agency missions, i.e., ERS1/2 (European remote-sensing satellite) and ENVISAT (environmental satellite), and the most recent data from COSMO-SkyMed constellations, it was possible to collect a 28-year dataset that was used to spatially analyze displacement patterns at a site-specific scale to check the stability of viaducts and embankments, and on a larger scale to understand the activity of the surrounding slopes. Despite the different resolution and subsequently the ground density, the analysis of the different datasets showed a spatiotemporal consistency in the displacement patterns that concerned two subareas showing significant annual velocity trends, one northeast of the city and the second in the port area. The analysis presented in this paper highlights how a complex geologic area, combining slope movements and various fault systems, could be a major concern for the stability of the overlying infrastructure and also the role that a PSI analysis can play in remotely monitoring their behavior over long periods of time.

In order to improve the observation capability in one of the most active volcanic areas in the world, Mt. Etna, we developed a processing method to use the surveillance cameras for a quasi real-time mapping of syn-eruptive processes. Following an evaluation of the current performance of the Etna permanent ground NEtwork of Thermal and Visible Sensors (Etna_NETVIS), its possible implementation and optimization was investigated to determine the locations of additional observation sites to be rapidly set up during emergencies. A tool was then devised to process time series of ground-acquired images and extract a coherent multi-temporal dataset of georeferenced map. The processed datasets can be used to extract 2D features such as evolution maps of active lava flows. The tool was validated on ad-hoc test fields and then adopted to map the evolution of two recent lava flows. The achievable accuracy (about three times the original pixel size) and the short processing time makes the tool suitable for rapidly assessing lava flow evolutions, especially in the case of recurrent eruptions, such as those of the 2011–2015 Etna activity. The tool can be used both in standard monitoring activities and during emergency phases (eventually improving the present network with additional mobile stations) when it is mandatory to carry out a quasi-real-time mapping to support civil protection actions. The developed tool could be integrated in the control room of the Osservatorio Etneo, thus enabling the Etna_NETVIS for mapping purposes and not only for video surveillance.

In order to improve the observation capability in one of the most active volcanic areas in the world, Mt. Etna, we developed a processing method to use the surveillance cameras for a quasi real-time mapping of syn-eruptive processes. Following an evaluation of the current performance of the Etna permanent ground NEtwork of Thermal and Visible Sensors (Etna_NETVIS), its possible implementation and optimization was investigated to determine the locations of additional observation sites to be rapidly set up during emergencies. A tool was then devised to process time series of ground-acquired images and extract a coherent multi-temporal dataset of georeferenced map. The processed datasets can be used to extract 2D features such as evolution maps of active lava flows. The tool was validated on ad-hoc test fields and then adopted to map the evolution of two recent lava flows. The achievable accuracy (about three times the original pixel size) and the short processing time makes the tool suitable for rapidly assessing lava flow evolutions, especially in the case of recurrent eruptions, such as those of the 2011–2015 Etna activity. The tool can be used both in standard monitoring activities and during emergency phases (eventually improving the present network with additional mobile stations) when it is mandatory to carry out a quasi-real-time mapping to support civil protection actions. The developed tool could be integrated in the control room of the Osservatorio Etneo, thus enabling the Etna_NETVIS for mapping purposes and not only for video surveillance. [ABSTRACT FROM AUTHOR]

In the absence of systematic structural monitoring to support adequate maintenance standards, many existing infrastructures may reach unacceptable quality levels during their life cycle, resulting in significant damage and even potential failure. The metropolitan area of the Gulf of Salerno (Italy), served by a complex multimodal transport network connecting the port area to the roads and railways surrounding the urban area, represents an important industrial and commercial hub at the local and international scale. This particular scenario, developed in a complex morphological and geological context, has led to the interference and overlapping of the transport network (highway, railway, main and secondary roads) that run through the piedmont area north of the port. Given the relevance of the area, our research aims to highlight the capabilities of the persistent scatterer interferometry (PSI) technique, belonging to the group of differential interferometric synthetic aperture radar (SAR), to extract space–temporal series of displacements on ground points or artifacts with millimeter accuracy useful to understand ongoing deformation processes. By using archived data from the European Space Agency missions, i.e., ERS1/2 (European remote-sensing satellite) and ENVISAT (environmental satellite), and the most recent data from COSMO-SkyMed constellations, it was possible to collect a 28-year dataset that was used to spatially analyze displacement patterns at a site-specific scale to check the stability of viaducts and embankments, and on a larger scale to understand the activity of the surrounding slopes. Despite the different resolution and subsequently the ground density, the analysis of the different datasets showed a spatiotemporal consistency in the displacement patterns that concerned two subareas showing significant annual velocity trends, one northeast of the city and the second in the port area. The analysis presented in this paper highlights how a complex geologic area, combining slope movements and various fault systems, could be a major concern for the stability of the overlying infrastructure and also the role that a PSI analysis can play in remotely monitoring their behavior over long periods of time. [ABSTRACT FROM AUTHOR]

This was a 24-week, multicenter phase-2 study designed to assess safety, tolerability, and pharmacodynamics of FBS0701, a novel oral chelator, in adults with transfusional iron overload. Fifty-one patients, stratified by transfusional iron intake, were randomized to FBS0701 at either 14.5 or 29 mg/kg/d (16 and 32 mg/kg/d salt form). FBS0701 was generally well tolerated at both doses. Forty-nine patients (96%) completed the study. There were no drug-related serious adverse events. No adverse events (AEs) showed dose-dependency in frequency or severity. Treatment-related nausea, vomiting, abdominal pain, and diarrhea were each noted in < 5% of patients. Mean serum creatinine did not change significantly from Baseline or between dose groups. Transaminases wer increased in 8 (16%), three of whom acquired HCV on-study from a single blood bank while five had an abnormal baseline ALT. The 24 week mean change in liver iron concentration (ΔLIC) at 14.5 mg/kg/d was +3.1 mg/g (dw); 29% achieved a decrease in LIC. Mean ΔLIC at 29 mg/kg/d was -0.3 mg/g (dw); 44% achieved a decrease in LIC (P < .03 for ΔLIC between doses). The safety and tolerability profile at therapeutic doses compare favorably to other oral chelators.

Aims: To evaluate the safety and tolerability of a new oral solution formulation of tolevamer potassium sodium, a nonantibiotic polymer that binds Clostridium difficile toxins A and B., Methods: This phase 1 randomized, double-blind, placebo-controlled study evaluated four doses of tolevamer potassium sodium in 40 healthy volunteers using a sequential dose escalation paradigm and doses of 6, 9, 12 and 15 g day(-1) for 9 days. Within each 10 patient cohort, eight patients received active treatment and two matching placebo. Placebo subjects were pooled to provide eight per arm. All subjects received three times daily dosing on days 2-8 as well as a loading dose (a single dose equal to the total daily dose) either on day 1 or day 9., Results: All 40 subjects completed the study per protocol. Treatment-emergent adverse events (TEAEs) were generally mild, transient, and resolved without sequelae. There were no serious AEs or deaths. There was no relationship detected between dose and the incidence of TEAEs, whether drug-related (all gastrointestinal disorders) or not. No clinically significant changes in laboratory parameters, including serum and urinary potassium concentrations, vital signs, and results of physical examination, were observed. A small but statistically significant reduction in 24 h urine potassium excretion was seen in the 15 g day(-1) dose group, and on day 10 in the 6 g day(-1) group., Conclusions: Tolevamer oral solution administered for 9 days at total daily doses up to 15 g, with loading doses of up to 15 g, was generally safe and well-tolerated in healthy volunteers.

Background: Current antibiotic therapies for Clostridium difficile-associated diarrhea have limitations, including progression to severe disease, recurrent C. difficile-associated diarrhea, and selection for nosocomial pathogens. Tolevamer, a soluble, high-molecular weight, anionic polymer that binds C. difficile toxins A and B is a unique nonantibiotic treatment option., Methods: In this 3-arm, multicenter, randomized, double-blind, active-controlled, parallel-design phase II study, patients with mild to moderately severe C. difficile-associated diarrhea were randomized to receive 3 g of tolevamer per day (n = 97), 6 g of tolevamer per day (n = 95), or 500 mg of vancomycin per day (n = 97). The primary efficacy parameter was time to resolution of diarrhea, defined as the first day of 2 consecutive days when the patient had hard or formed stools (any number) or < or = 2 stools of loose or watery consistency., Results: In the per-protocol study population, resolution of diarrhea was achieved in 48 (67%) of 72 patients receiving 3 g of tolevamer per day (median time to resolution of diarrhea, 4.0 days; 95% confidence interval, 2.0-6.0 days), in 58 (83%) of 70 patients receiving 6 g of tolevamer per day (median time to resolution of diarrhea, 2.5 days; 95% confidence interval, 2.0-3.0 days), and in 73 (91%) of 80 patients receiving vancomycin (median time to resolution of diarrhea, 2.0 days; 95% confidence interval, 1.0-3.0 days). Tolevamer administered at a dosage of 6 g per day was found to be noninferior to vancomycin administered at a dosage of 500 mg per day with regard to time to resolution of diarrhea (P = .02) and was associated with a trend toward a lower recurrence rate. Tolevamer was well tolerated but was associated with an increased risk of hypokalemia., Conclusions: Tolevamer, a novel polystyrene binder of C. difficile toxins A and B, effectively treats mild to moderate C. difficile diarrhea and merits further clinical development.

A 4-year retrospective study showing that we isolated Bordetella holmesii, but not Bordetella pertussis, from patients with pertussis-like symptoms was performed. From 1995 through 1998, we isolated B. holmesii from 32 nasopharyngeal specimens that had been submitted from patients suspected of having pertussis. Previously, B. holmesii had been associated mainly with septicemia and was not thought to be associated with respiratory illness. A study was undertaken to describe the characteristics of the B. holmesii isolates recovered and why we were successful in detecting the organism in nasopharyngeal specimens. B. holmesii isolates were characterized for drug sensitivities and for genetic relatedness by pulsed-field gel electrophoresis (PFGE). These isolates, an additional strain of B. holmesii isolated from a blood culture and previously confirmed by the Centers for Disease Control and Prevention, Atlanta, Ga., and 14 other clinical isolates of Bordetella spp., including 4 of B. bronchiseptica, 5 of B. parapertussis, and 5 of B. pertussis, were studied. They were all separately inoculated on three Bordet Gengou (BG) selective media containing either 0.625 microgram of oxacillin per ml, 40 microgram of cephalexin per ml, or 2.5 microgram of methicillin per ml, on BG agar with no antibiotic (control), and on charcoal agar (CA) with and without 40 microgram of cephalexin per ml. We found that cephalexin, the antibiotic commonly incorporated in both CA and BG agar for the recovery of Bordetella spp., is inhibitory to the growth of B. holmesii. In addition, the genotypic analysis of the 32 B. holmesii isolates by PFGE following restriction with XbaI and SpeI identified the dominant strains circulating during the study period.

A total of 66 isolates of Salmonella javiana isolated from food, food handlers, and patrons that were epidemiologically linked to an outbreak of gastroenteritis were analyzed by pulsed-field gel electrophoresis. Analysis with restriction endonucleases XbaI and SpeI supported the epidemiologic association and suggested a pathway of transmission among food, food handlers, and patrons.

We report on two outbreaks of Salmonella enteritidis which occurred in 1992; both were associated with Monte Cristo sandwiches. The first outbreak, which occurred in Woods Hole, Massachusetts, was investigated as a case-control study, and involved 74 persons. The second outbreak, investigated as a cohort study, occurred in Brewster, Massachusetts, and involved 32 persons. Monte Cristo sandwiches were strongly implicated in both outbreaks; the odds ratio in the case-control study was 43, and the relative risk in the cohort study was 13. Food-preparation procedures were reviewed and food handlers were educated about safe food-preparation practices. Because of the short grilling time for Monte Cristo sandwiches, (usually several minutes) the eggs used in the preparation may only be partially cooked. As a result, this food should be viewed as high risk for S. enteritidis . Pasteurized eggs should be used to prepare Monte Cristo sandwiches, especially in a commercial setting.

The relationship between superstitious beliefs and behaviors, and measures of obsessive-compulsive experiences was examined in this study. Both superstitious beliefs and superstitious behaviors were correlated with measures of compulsivity and obsessionality. Compulsive checking, but not compulsive cleaning (from the MOCI and the CAC-R) were correlated with superstitiousness. Both subscales from the Obsessional Thoughts Questionnaire were correlated with superstitiousness. The implications of these findings for the role of perceived control in obsessive-compulsive phenomena were discussed.

Four recent outbreaks of pertussis in Massachusetts illustrate some features that contribute to the increased incidence of the disease. The outbreaks involved unimmunized groups of children with philosophical or religious exemptions from school or day-care immunization requirements and children and adults who were reluctant to undergo antibiotic prophylaxis or therapy. Parents and physicians should be aware that failure to immunize and to cooperate in follow-up preventive measures can have public health and potential medicolegal repercussions.