Search

Your search keyword '"Pennone, Mauro"' showing total 28 results
Start Over Author "Pennone, Mauro"
28 results on '"Pennone, Mauro"'

2. Provisional versus elective two-stent strategy for unprotected true left main bifurcation lesions: Insights from a FAILS-2 sub-study

Author

Kawamoto, Hiroyoshi, Chieffo, Alaide, D'Ascenzo, Fabrizio, Jabbour, Richard J., Naganuma, Toru, Cerrato, Enrico, Ugo, Fabrizio, Pavani, Marco, Varbella, Ferdinando, Boccuzzi, Giacomo, Pennone, Mauro, Garbo, Roberto, Conrotto, Federico, Biondi-Zoccai, Giuseppe, D'Amico, Maurizio, Moretti, Claudio, Escaned, Javier, Gaita, Fiorenzo, Nakamura, Sunao, and Colombo, Antonio

Published
2018
Full Text
View/download PDF

3. Percutaneous coronary intervention or coronary artery bypass graft in left main coronary artery disease: a comprehensive meta-analysis of adjusted observational studies and randomized controlled trials

Author

Bertaina, Maurizio, De Filippo, Ovidio, Iannaccone, Mario, Colombo, Antonio, Stone, Gregg, Serruys, Patrick, Mancone, Massimo, Omedè, Pierluigi, Conrotto, Federico, Pennone, Mauro, Kimura, Takeshi, Kawamoto, Hiroyoshi, Zoccai, Giuseppe Biondi, Sheiban, Imad, Templin, Christian, Benedetto, Umberto, Cavalcante, Rafael, D’Amico, Maurizio, Gaudino, Mario, Moretti, Claudio, Gaita, Fiorenzo, and D’Ascenzo, Fabrizio

Published
2018
Full Text
View/download PDF

5. Percutaneous vs. surgical revascularization for patients with unprotected left main stenosis: a meta-analysis of 5 years follow-up RCTs

Author

D'Ascenzo, Fabrizio, De Filippo, Ovidio, Elia, Edoardo, Doronzo, Mattia Paolo, Omedè, Pierluigi, Montefusco, Antonio, Pennone, Mauro, Salizzoni, Stefano, Conrotto, Federico, Gallone, Guglielmo, Angelini, Filippo, Franchin, Luca, Bruno, Francesco, Boffini, Massimo, Gaudino, Mario, Rinaldi, Mauro, and De Ferrari, Gaetano Maria

Subjects
meta-analysis, Coronary artery disease, Unprotected left main (ULM), coronary artery bypass graft (CABG), percutaneous coronary intervention (PCI)
Published
2021

6. Machine learning-based prediction of adverse events following an acute coronary syndrome (PRAISE): a modelling study of pooled datasets

Author

D'Ascenzo, Fabrizio, primary, De Filippo, Ovidio, additional, Gallone, Guglielmo, additional, Mittone, Gianluca, additional, Deriu, Marco Agostino, additional, Iannaccone, Mario, additional, Ariza-Solé, Albert, additional, Liebetrau, Christoph, additional, Manzano-Fernández, Sergio, additional, Quadri, Giorgio, additional, Kinnaird, Tim, additional, Campo, Gianluca, additional, Simao Henriques, Jose Paulo, additional, Hughes, James M, additional, Dominguez-Rodriguez, Alberto, additional, Aldinucci, Marco, additional, Morbiducci, Umberto, additional, Patti, Giuseppe, additional, Raposeiras-Roubin, Sergio, additional, Abu-Assi, Emad, additional, De Ferrari, Gaetano Maria, additional, Piroli, Francesco, additional, Saglietto, Andrea, additional, Conrotto, Federico, additional, Omedé, Pierluigi, additional, Montefusco, Antonio, additional, Pennone, Mauro, additional, Bruno, Francesco, additional, Bocchino, Pier Paolo, additional, Boccuzzi, Giacomo, additional, Cerrato, Enrico, additional, Varbella, Ferdinando, additional, Sperti, Michela, additional, Wilton, Stephen B., additional, Velicki, Lazar, additional, Xanthopoulou, Ioanna, additional, Cequier, Angel, additional, Iniguez-Romo, Andres, additional, Munoz Pousa, Isabel, additional, Cespon Fernandez, Maria, additional, Caneiro Queija, Berenice, additional, Cobas-Paz, Rafael, additional, Lopez-Cuenca, Angel, additional, Garay, Alberto, additional, Blanco, Pedro Flores, additional, Rognoni, Andrea, additional, Biondi Zoccai, Giuseppe, additional, Biscaglia, Simone, additional, Nunez-Gil, Ivan, additional, Fujii, Toshiharu, additional, Durante, Alessandro, additional, Song, Xiantao, additional, Kawaji, Tetsuma, additional, Alexopoulos, Dimitrios, additional, Huczek, Zenon, additional, Gonzalez Juanatey, Jose Ramon, additional, Nie, Shao-Ping, additional, Kawashiri, Masa-aki, additional, Colonnelli, Iacopo, additional, Cantalupo, Barbara, additional, Esposito, Roberto, additional, Leonardi, Sergio, additional, Grosso Marra, Walter, additional, Chieffo, Alaide, additional, Michelucci, Umberto, additional, Piga, Dario, additional, Malavolta, Marta, additional, Gili, Sebastiano, additional, Mennuni, Marco, additional, Montalto, Claudio, additional, Oltrona Visconti, Luigi, additional, and Arfat, Yasir, additional

Published
2021
Full Text
View/download PDF

7. Fractional flow reserve guided versus angiographic guided surgical revascularization: A meta‐analysis

Author

Bruno, Francesco, primary, D'Ascenzo, Fabrizio, additional, Marengo, Giorgio, additional, Manfredi, Roberto, additional, Saglietto, Andrea, additional, Gallone, Guglielmo, additional, Franchin, Luca, additional, Piroli, Francesco, additional, Angelini, Filippo, additional, De Filippo, Ovidio, additional, Conrotto, Federico, additional, Omedè, Pierluigi, additional, Montefusco, Antonio, additional, Pennone, Mauro, additional, Boffini, Massimo, additional, Pocar, Marco, additional, Rinaldi, Mauro, additional, and De Ferrari, Gaetano Maria, additional

Published
2020
Full Text
View/download PDF

9. Reduced Rate of Hospital Admissions for ACS during Covid-19 Outbreak in Northern Italy

Author

De Filippo, Ovidio, primary, D’Ascenzo, Fabrizio, additional, Angelini, Filippo, additional, Bocchino, Pier Paolo, additional, Conrotto, Federico, additional, Saglietto, Andrea, additional, Secco, Gioel Gabrio, additional, Campo, Gianluca, additional, Gallone, Guglielmo, additional, Verardi, Roberto, additional, Gaido, Luca, additional, Iannaccone, Mario, additional, Galvani, Marcello, additional, Ugo, Fabrizio, additional, Barbero, Umberto, additional, Infantino, Vincenzo, additional, Olivotti, Luca, additional, Mennuni, Marco, additional, Gili, Sebastiano, additional, Infusino, Fabio, additional, Vercellino, Matteo, additional, Zucchetti, Ottavio, additional, Casella, Gianni, additional, Giammaria, Massimo, additional, Boccuzzi, Giacomo, additional, Tolomeo, Paolo, additional, Doronzo, Baldassarre, additional, Senatore, Gaetano, additional, Grosso Marra, Walter, additional, Rognoni, Andrea, additional, Trabattoni, Daniela, additional, Franchin, Luca, additional, Borin, Andrea, additional, Bruno, Francesco, additional, Galluzzo, Alessandro, additional, Gambino, Alfonso, additional, Nicolino, Annamaria, additional, Truffa Giachet, Alessandra, additional, Sardella, Gennaro, additional, Fedele, Francesco, additional, Monticone, Silvia, additional, Montefusco, Antonio, additional, Omedè, Pierluigi, additional, Pennone, Mauro, additional, Patti, Giuseppe, additional, Mancone, Massimo, additional, and De Ferrari, Gaetano M., additional

Published
2020
Full Text
View/download PDF

10. Percutaneous vs. surgical revascularization for patients with unprotected left main stenosis: a meta-analysis of 5-year follow-up randomized controlled trials

Author

D’Ascenzo, Fabrizio, primary, De Filippo, Ovidio, additional, Elia, Edoardo, additional, Doronzo, Mattia Paolo, additional, Omedè, Pierluigi, additional, Montefusco, Antonio, additional, Pennone, Mauro, additional, Salizzoni, Stefano, additional, Conrotto, Federico, additional, Gallone, Guglielmo, additional, Angelini, Filippo, additional, Franchin, Luca, additional, Bruno, Francesco, additional, Boffini, Massimo, additional, Gaudino, Mario, additional, Rinaldi, Mauro, additional, and De Ferrari, Gaetano Maria, additional

Published
2020
Full Text
View/download PDF

11. Impact of structural features of very thin stents implanted in unprotected left main or coronary bifurcations on clinical outcomes

Author

Iannaccone, Mario, primary, D'Ascenzo, Fabrizio, additional, Gallone, Guglielmo, additional, Mitomo, Satoru, additional, Parma, Radosław, additional, Trabattoni, Daniela, additional, Ryan, Nicola, additional, Muscoli, Saverio, additional, Venuti, Giuseppe, additional, Montabone, Andrea, additional, De Lio, Francesca, additional, Zaccaro, Lorenzo, additional, Quadri, Giorgio, additional, De Filippo, Ovidio, additional, Wojakowski, Wojciech, additional, Rognoni, Andrea, additional, Helft, Gerard, additional, Gallo, Diego, additional, De Luca, Leonardo, additional, Figini, Filippo, additional, Imori, Yoichi, additional, Conrotto, Federico, additional, Boccuzzi, Giacomo, additional, Mattesini, Alessio, additional, Wańha, Wojciech, additional, Smolka, Grzegorz, additional, Huczek, Zenon, additional, Rolfo, Cristina, additional, Pennone, Mauro, additional, Cortese, Bernardo, additional, Capodanno, Davide, additional, Chieffo, Alaide, additional, Nuñez‐Gil, Ivan, additional, Morbiducci, Umberto, additional, D'Amico, Maurizio, additional, Varbella, Ferdinando, additional, Romeo, Francesco, additional, Sheiban, Imad, additional, Escaned, Javier, additional, Garbo, Roberto, additional, Moretti, Claudio, additional, Mario, Carlo, additional, and De Ferrari, Gaetano M., additional

Published
2019
Full Text
View/download PDF

12. Daily risk of adverse outcomes in patients undergoing complex lesions revascularization: A subgroup analysis from the RAIN-CARDIOGROUP VII study (veRy thin stents for patients with left mAIn or bifurcatioN in real life)

Author

Biolè, Carloalberto, Huczek, Zenon, Nuñez-Gil, Ivan, Boccuzzi, Giacomo, Autelli, Michele, Montefusco, Antonio, Trabattoni, Daniela, Ryan, Nicola, Venuti, Giuseppe, Imori, Yoichi, Takano, Hitoshi, Matsuda, Junya, Shimizu, Wataru, Muscoli, Saverio, Montabone, Andrea, Wojakowski, Wojciech, Rognoni, Andrea, Helft, Gerard, Gallo, Diego, Parma, Radoslaw, De Luca, Leonardo, Figini, Filippo, Mitomo, Satoru, Pennone, Mauro, Mattesini, Alessio, Templin, Christian, Quadri, Giorgio, Wańha, Wojciech, Cerrato, Enrico, Smolka, Grzegorz, et al, University of Zurich, and Biolè, Carloalberto

Subjects
10209 Clinic for Cardiology, 610 Medicine & health, 2705 Cardiology and Cardiovascular Medicine
Published
2019

13. Fractional flow reserve guided versus angiographic guided surgical revascularization: A meta-analysis.

Author

Bruno, Francesco, D'Ascenzo, Fabrizio, Marengo, Giorgio, Manfredi, Roberto, Saglietto, Andrea, Gallone, Guglielmo, Franchin, Luca, Piroli, Francesco, Angelini, Filippo, De Filippo, Ovidio, Conrotto, Federico, Omedè, Pierluigi, Montefusco, Antonio, Pennone, Mauro, Boffini, Massimo, Pocar, Marco, Rinaldi, Mauro, and Maria De Ferrari, Gaetano

Published
2021
Full Text
View/download PDF

14. Long-Term Outcomes of Different Two-Stent Techniques With Second-Generation Drug-Eluting Stents for Unprotected Left Main Bifurcation Disease: Insights From the FAILS-2 Study

Author

Pavani, Marco, Conrotto, Federico, Cerrato, Enrico, D Ascenzo, Fabrizio, Kawamoto, Hiroyoshi, Nunez-Gil, Ivan J., Pennone, Mauro, Garbo, Roberto, Tomassini, Francesco, Colombo, Francesco, Scacciatella, Paolo, Varbella, Ferdinando, Chieffo, Alaide, antonio colombo, and Escaned, Avier

Subjects
Male, Time Factors, Incidence, LM bifurcation disease, T-stenting technique, culotte technique, mini-crush technique, two-stent strategies, Aged, Coronary Angiography, Coronary Artery Disease, Coronary Vessels, Europe, Female, Follow-Up Studies, Humans, Japan, Percutaneous Coronary Intervention, Postoperative Complications, Prosthesis Design, Retrospective Studies, Risk Factors, Drug-Eluting Stents, Registries
Abstract

To investigate the long-term clinical outcomes of second-generation drug-eluting stent (2G-DES) implantation for the treatment of complex unprotected left main coronary artery (ULMCA) bifurcation lesions with different two-stent techniques.Several two-stent techniques for ULMCA bifurcation lesions have been described. However, a paucity of data exists regarding the optimal strategy, especially in the 2G-DES era.The FAILS-2 registry enrolled 1270 consecutive patients treated for ULMCA stenosis with 2G-DES. We compared long-term outcomes of different two-stent strategies in patients who underwent PCI for complex ULMCA bifurcation disease. The primary endpoints were the incidence of death and major adverse cardiac events (MACE, defined as a composite of all-cause death, myocardial infarction [MI], target-lesion revascularization [TLR], and stent thrombosis [ST]) at long-term follow-up.A total of 238 patients were included in the present analysis. T-stenting strategy was used in 66 patients, mini-crush in 104 patients, and culotte in 68 patients. After a median follow-up of 2.27 years, death rates were comparable for the three techniques (9.3% T-stenting vs 9.0% mini-crush vs 4.5% culotte [P=.48]). MACE rates were also similar between the three groups (22% T-stenting vs 26% mini-crush vs 31% culotte [P=.50]). Finally, we showed no differences in MI, ST, and TLR rates between groups. At multivariate analysis, no significant advantage of one technique over the others was observed.T-stenting, mini-crush, and culotte techniques using 2G-DES for ULMCA bifurcation disease showed similar clinical outcomes at long-term follow-up. MACE rates were mainly driven by in-stent restenosis at the circumflex ostium.

Published
2018

15. Daily risk of adverse outcomes in patients undergoing complex lesions revascularization: A subgroup analysis from the RAIN-CARDIOGROUP VII study (veRy thin stents for patients with left mAIn or bifurcatioN in real life)

Author

Biolè, Carloalberto, primary, Huczek, Zenon, additional, Nuñez-Gil, Ivan, additional, Boccuzzi, Giacomo, additional, Autelli, Michele, additional, Montefusco, Antonio, additional, Trabattoni, Daniela, additional, Ryan, Nicola, additional, Venuti, Giuseppe, additional, Imori, Yoichi, additional, Takano, Hitoshi, additional, Matsuda, Junya, additional, Shimizu, Wataru, additional, Muscoli, Saverio, additional, Montabone, Andrea, additional, Wojakowski, Wojciech, additional, Rognoni, Andrea, additional, Helft, Gerard, additional, Gallo, Diego, additional, Parma, Radoslaw, additional, De Luca, Leonardo, additional, Figini, Filippo, additional, Mitomo, Satoru, additional, Pennone, Mauro, additional, Mattesini, Alessio, additional, Templin, Christian, additional, Quadri, Giorgio, additional, Wańha, Wojciech, additional, Cerrato, Enrico, additional, Smolka, Grzegorz, additional, Protasiewicz, Marcin, additional, Kuliczkowski, Wiktor, additional, Rolfo, Cristina, additional, Cortese, Bernardo, additional, Capodanno, Davide, additional, Chieffo, Alaide, additional, Morbiducci, Umberto, additional, Iannaccone, Mario, additional, Gili, Sebastiano, additional, di Mario, Carlo, additional, D'Amico, Maurizio, additional, Romeo, Francesco, additional, Lüscher, Thomas F., additional, Sheiban, Imad, additional, Escaned, Javier, additional, Varbella, Ferdinando, additional, and D'Ascenzo, Fabrizio, additional

Published
2019
Full Text
View/download PDF

16. Percutaneous vs. surgical revascularization for patients with unprotected left main stenosis: a meta-analysis of 5-year follow-up randomized controlled trials

Author

D’Ascenzo, Fabrizio, De Filippo, Ovidio, Elia, Edoardo, Doronzo, Mattia Paolo, Omedè, Pierluigi, Montefusco, Antonio, Pennone, Mauro, Salizzoni, Stefano, Conrotto, Federico, Gallone, Guglielmo, Angelini, Filippo, Franchin, Luca, Bruno, Francesco, Boffini, Massimo, Gaudino, Mario, Rinaldi, Mauro, and De Ferrari, Gaetano Maria

Published
2021
Full Text
View/download PDF

17. Corrigendum to “Provisional versus elective two-stent strategy for unprotected true left main bifurcation lesions: Insights from a FAILS-2 sub-study” [Int. J. Cardiol. 250 (2018) 80–85]

Author

Kawamoto, Hiroyoshi, primary, Chieffo, Alaide, additional, D'Ascenzo, Fabrizio, additional, Jabbour, Richard J., additional, Naganuma, Toru, additional, Cerrato, Enrico, additional, Ugo, Fabrizio, additional, Pavani, Marco, additional, Varbella, Ferdinando, additional, Boccuzzi, Giacomo, additional, Pennone, Mauro, additional, Garbo, Roberto, additional, Conrotto, Federico, additional, Biondi-Zoccai, Giuseppe, additional, D'Amico, Maurizio, additional, Moretti, Claudio, additional, Escaned, Javier, additional, Gaita, Fiorenzo, additional, Nakamura, Sunao, additional, and Colombo, Antonio, additional

Published
2018
Full Text
View/download PDF

18. Impact of chronic kidney disease on mortality in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention. A long-term single-center mortality study

Author

Peyracchia, Mattia, primary, Scacciatella, Paolo, additional, Conrotto, Federico, additional, Meynet, Ilaria, additional, Biava, Lorenza M., additional, Budano, Carlo, additional, Pennone, Mauro, additional, D'''''Amico, Maurizio, additional, and Gaita, Fiorenzo, additional

Published
2017
Full Text
View/download PDF

24. Provisional versus elective two-stent strategy for unprotected true left main bifurcation lesions: Insights from a FAILS-2 sub-study

Author

Giuseppe Biondi-Zoccai, Fabrizio D'Ascenzo, Maurizio D'Amico, Federico Conrotto, Claudio Moretti, Ferdinando Varbella, Sunao Nakamura, Richard J. Jabbour, Toru Naganuma, Javier Escaned, Mauro Pennone, Roberto Garbo, Marco Pavani, Antonio Colombo, Giacomo Boccuzzi, Fiorenzo Gaita, Enrico Cerrato, Fabrizio Ugo, Hiroyoshi Kawamoto, Alaide Chieffo, Kawamoto, Hiroyoshi, Chieffo, Alaide, D'Ascenzo, Fabrizio, Jabbour, Richard J, Naganuma, Toru, Cerrato, Enrico, Ugo, Fabrizio, Pavani, Marco, Varbella, Ferdinando, Boccuzzi, Giacomo, Pennone, Mauro, Garbo, Roberto, Conrotto, Federico, Biondi zoccai, Giuseppe, D'Amico, Maurizio, Moretti, Claudio, Escaned, Javier, Gaita, Fiorenzo, Nakamura, Sunao, and Colombo, Antonio

Subjects
Male, medicine.medical_specialty, True bifurcation lesions, medicine.medical_treatment, Coronary Artery Disease, 030204 cardiovascular system & hematology, Percutaneous coronary intervention, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Statistical significance, medicine, Humans, Registries, 030212 general & internal medicine, Circumflex, Drug-eluting stent, Unprotected left main coronary artery, Cardiology and Cardiovascular Medicine, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Stent, Drug-Eluting Stents, Middle Aged, medicine.disease, Coronary Vessels, Surgery, Conventional PCI, Cardiology, Female, True bifurcation lesion, business, Mace, Follow-Up Studies
Abstract

Background This study sought to investigate the optimal percutaneous coronary intervention (PCI) strategy for true unprotected left main coronary artery (ULMCA) bifurcations. Methods The FAILS-2 was a retrospective multi-center study including patients with ULMCA disease treated with second-generation drug-eluting stents. Of these, we compared clinical outcomes of a provisional strategy (PS; n=216) versus an elective two-stent strategy (E2S; n=161) for true ULMCA bifurcations. The primary endpoint was the incidence of major adverse cardiac events (MACEs) at 3-years. We further performed propensity-score adjustment for clinical outcomes. Results There were no significant differences between the groups in terms of patient and lesion characteristics. 9.7% of patients in the PS group crossed over to a provisional two-stent strategy. MACEs were not significantly different between groups (MACE at 3-year; PS 28.1% vs. E2S 28.9%, adjusted p=0.99). The rates of target lesion revascularization (TLR) on the circumflex artery (LCX) were numerically high in the E2S group (LCX-TLR at 3-years; PS 11.8% vs. E2S 16.6%, adjusted p=0.51). Conclusions E2S was associated with a comparable MACE rate to PS for true ULMCA bifurcations. The rates of LCX-TLR tended to be higher in the E2S group although there was no statistical significance. Condensed abstract This study sought to compare the clinical outcomes of a provisional strategy (PS) with an elective two-stent strategy (E2S) for the treatment of true unprotected left main coronary artery bifurcations. 377 Patients (PS 216 vs. E2S 161 patients) were evaluated, and 9.7% in the PS group crossed over to a two-stent strategy. E2S was associated with a similar major adverse cardiac event rate at 3-years when compared to the PS strategy (PS 28.1% vs. E2S 28.9%, p=0.99). However, the left circumflex artery TLR rate at 3-year tended to be higher in the E2S group (PS 11.8% vs. E2S 16.6%, p=0.51).

Published
2018

25. Percutaneous vs. surgical revascularization for patients with unprotected left main stenosis: a meta-analysis of 5-year follow-up randomized controlled trials.

Author

D'Ascenzo F, De Filippo O, Elia E, Doronzo MP, Omedè P, Montefusco A, Pennone M, Salizzoni S, Conrotto F, Gallone G, Angelini F, Franchin L, Bruno F, Boffini M, Gaudino M, Rinaldi M, and De Ferrari GM

Subjects
Aged, Constriction, Pathologic etiology, Follow-Up Studies, Humans, Randomized Controlled Trials as Topic, Treatment Outcome, Coronary Artery Bypass adverse effects
Abstract

Aims: A 5-year survival of patients with unprotected left main (ULM) stenosis according to the choice of revascularization (percutaneous vs. surgical) remains to be defined., Methods and Results: Randomized controlled trials (RCTs) comparing percutaneous coronary intervention (PCI) vs. coronary artery bypass graft (CABG) with a follow-up of at least 5 years were included. All-cause death was the primary endpoint. MACCE [a composite endpoint of all-cause mortality, myocardial infarction (MI), stroke, and repeat revascularization] along with its single components and cardiovascular (CV) death were the secondary ones. Analyses were stratified according to the use of first- vs. last-generation coronary stents. Subgroup comparisons were performed according to SYNTAX score (below or above 33) and to age (using cut-offs of each trial's subgroup analysis). Four RCTs with 4394 patients were identified: 2197 were treated with CABG, 657 with first generation, and 1540 with last-generation stents. At 5-year rates of all-cause death did not differ [odds ratio (OR) 0.93, 95% confidence interval (CI) 0.71-1.21], as those of CV death and stroke. Coronary artery bypass graft reduced rates of MACCE (OR 0.69, 95% CI 0.60-0.79), mainly driven by MI (OR 0.48, 95% CI 0.36-0.65) and revascularization (OR 0.53, 95% CI 0.45-0.64). Benefit of CABG for MACCE was consistent, although with different extent, across values of SYNTAX score (OR 0.76, 95% CI 0.59-0.97 for values < 32 and OR 0.63, 95% CI 0.47-0.84 for values ≥ 33) while was not evident for 'younger' patients (OR 0.83, 95% CI 0.65-1.07 vs. OR 0.65, 95% CI 0.51-0.84 for 'older' patients)., Conclusion: For patients with ULM disease followed-up for 5 years, no significant difference was observed in all-cause and cardiovascular death between PCI and CABG. Coronary artery bypass graft reduced risk of MI, revascularization, and MACCE especially in older patients and in those with complex coronary disease and a high SYNTAX score., (Published on behalf of the European Society of Cardiology.)

Published
2021
Full Text
View/download PDF

26. Impact of structural features of very thin stents implanted in unprotected left main or coronary bifurcations on clinical outcomes.

Author

Iannaccone M, D'Ascenzo F, Gallone G, Mitomo S, Parma R, Trabattoni D, Ryan N, Muscoli S, Venuti G, Montabone A, De Lio F, Zaccaro L, Quadri G, De Filippo O, Wojakowski W, Rognoni A, Helft G, Gallo D, De Luca L, Figini F, Imori Y, Conrotto F, Boccuzzi G, Mattesini A, Wańha W, Smolka G, Huczek Z, Rolfo C, Pennone M, Cortese B, Capodanno D, Chieffo A, Nuñez-Gil I, Morbiducci U, D'Amico M, Varbella F, Romeo F, Sheiban I, Escaned J, Garbo R, Moretti C, di Mario C, and De Ferrari GM

Subjects
Aged, Coronary Artery Disease diagnostic imaging, Europe, Female, Humans, Male, Middle Aged, Percutaneous Coronary Intervention adverse effects, Prosthesis Design, Registries, Retrospective Studies, Risk Assessment, Risk Factors, Time Factors, Treatment Outcome, Coronary Artery Disease therapy, Drug-Eluting Stents, Percutaneous Coronary Intervention instrumentation
Abstract

Objectives: To evaluate the independent clinical impact of stent structural features in a large cohort of patients undergoing unprotected left main (ULM) or coronary bifurcation percutaneous coronary intervention (PCI) with a range of very thin strut stents., Background: Clinical impact of structural features of contemporary stents remains to be defined., Methods: All consecutive patients enrolled in the veRy thin stents for patients with left mAIn or bifurcatioN in real life (RAIN) registry were included. The following stent structural features were studied: antiproliferative drugs (everolimus vs. sirolimus vs. zotarolimus), strut material (platinum-chromium vs. cobalt-chromium), polymer (bioresorbable vs. durable), number of crowns (<8 vs. ≥8) and number of connectors (<3 vs. ≥3). For small diameter stents (≤2.5 mm), struct thickness (74 vs. 80/81 μm) was also tested. Target lesion failure (TLF), a composite of target lesion revascularization and stent thrombosis, was the primary endpoint. Multivariate analysis was performed with Cox regression models., Results: Out of 2,707 patients, 110 (4.1%) experienced a TLF event after 16 months (12-18). After adjustment for confounders, an increased number of connectors (adjusted hazard ratio [adj-HR] 0.62, 95% confidence interval (CI) 0.39-0.99, p = .04) reduced risk of TLF, driven by stents with ≥2.5 mm diameter (HR 0.54, 95% CI 0.32-0.93, p = .02). This independent relationship was lost for stents with diameter <2.5 mm, where only strut thickness appeared to impact. Conversely, no independent relationship of polymer type, number of crowns, and the specific limus-family eluted drug with outcomes was observed., Conclusions: Among a range of contemporary very thin stent models, an increased number of connectors improved device-related outcomes in this investigated high-risk procedural setting., (© 2019 Wiley Periodicals, Inc.)

Published
2020
Full Text
View/download PDF

27. Impact of chronic kidney disease on mortality in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention. A long-term single-center mortality study.

Author

Peyracchia M, Scacciatella P, Conrotto F, Meynet I, Biava LM, Budano C, Pennone M, D'Amico M, and Gaita F

Subjects
Aged, Cohort Studies, Female, Follow-Up Studies, Glomerular Filtration Rate, Humans, Male, Middle Aged, Prognosis, Prospective Studies, Renal Insufficiency, Chronic physiopathology, ST Elevation Myocardial Infarction mortality, Severity of Illness Index, Time Factors, Hospital Mortality, Percutaneous Coronary Intervention methods, Renal Insufficiency, Chronic mortality, ST Elevation Myocardial Infarction therapy
Abstract

Background: Chronic kidney disease (CKD) is associated with increased risk of mortality. We examined the impact of moderate and severe CKD at presentation on short- and long-term mortality among unselected patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PPCI)., Methods: The study cohort consists of 501 patients (pts), enrolled from October 2005 to December 2012. The median follow-up was 46.52±25.58 months (range 8-99). A severe CKD (estimated Glomerular Filtration Rate [eGFR] <30 mL/min/1.73 m2) was detected in 16 pts (3.19%), a moderate CKD (eGFR 30-59 mL/min/1.73 m2) in 110 (21.96%) and a normal kidney function (eGFR >60 mL/min/1.73 m2) in 375 (74.85%)., Results: The crude in-hospital mortality rate resulted significantly higher in pts with severe and moderate CKD compared to pts with normal renal function (50% and 19.08% versus 2.93%, P<0.0001), as well as the long-term mortality rate (57.14% and 46.34% versus 8.77%, P<0.0001). After adjustment for confounding variables, severe and moderate CKD resulted the main independent predictors of in-hospital (odds ratio [OR]=21.815, P<0.0001 for severe CKD and OR= 4.203, P=0.002 for moderate CKD) and long-term (hazard ratio [HR]= 5.272, P=0.001; HR= 1.978, P=0.006) mortality., Conclusions: CKD is a frequent condition in patients with STEMI treated with PPCI and it is associated to an excess of mortality, resulting the main independent negative prognostic predictor.

Published
2018
Full Text
View/download PDF

28. [Feasibility and safety of same-day discharge after percutaneous coronary intervention with femoral access and AngioSeal closure device: a single-center experience].

Author

Pennone M, D'Amico M, Frisenda V, Scacciatella P, Conrotto F, Budano C, Seren Gay M, and Marra S

Subjects
Adult, Aged, Angioplasty, Balloon, Coronary methods, Coronary Angiography instrumentation, Coronary Artery Disease diagnostic imaging, Feasibility Studies, Female, Follow-Up Studies, Humans, Male, Middle Aged, Patient Satisfaction, Patient Selection, Retrospective Studies, Risk Assessment, Risk Factors, Treatment Outcome, Ambulatory Surgical Procedures, Angioplasty, Balloon, Coronary instrumentation, Coronary Artery Disease therapy, Femoral Artery, Patient Discharge
Abstract

Background: Same-day discharge after coronary angiography or percutaneous coronary interventions (PCI) is safe. It allows a decrease in length of hospital stay, waiting list and operating expenses with increased patient satisfaction. The aim of this study was to evaluate the feasibility and safety of this approach in our center., Methods: 798 selected patients considered suitable for same-day discharge were enrolled in our study and underwent coronary angiography and/or PCI procedures over a period of 5 years. All procedures were performed by femoral approach using the 6-8F AngioSeal closure device. A follow-up telephone interview was carried out in all patients after 7-10 days from discharge with particular regard to bleeding/vascular complications., Results: After PCI procedures, 738 patients (92.4%) were discharged as day cases. The remaining 60 patients (7.6%) were kept in hospital for longer observation. Procedural success was achieved in 100% of patients. Hemostasis with the AngioSeal closure device was successfully obtained in 98.4% of cases. At follow-up, 6 patients developed mild size hematoma on femoral access site, without any other vascular complications or major bleeding needing blood transfusion., Conclusions: In our experience same-day discharge after coronary angiography or PCI was found to be feasible and safe in selected patients undergoing uncomplicated procedures performed by femoral approach using a closure device.

Published
2011
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results