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10. 749P Patient-reported outcomes (PROs) in patients (pts) with mismatch repair deficient (dMMR)/microsatellite instability-high (MSI-H) primary advanced or recurrent endometrial cancer (pA/rEC) in the ENGOT-EN6-NSGO/GOG3031/RUBY trial

Author

Valabrega, G., Powell, M.A., Hietanen, S., Miller, E.M., Novák, Z., Holloway, R., Denschlag, D., Myers, T., Thijs, A.M., Pennington, K., Gilbert, L., Fleming, E., Copeland, L., Gogoi, R., Podzielinski, I., Cloven, N., Meyers, O., Garside, J., Mirza, M.R., and Black, D.

Published
2023
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15. A unified call to action from Australian nursing and midwifery leaders: Ensuring that Black lives matter

Author

Geia, L., Baird, K., Bail, K., Barclay, L., Bennett, J., Best, O., Birks, M., Blackley, L., Blackman, R., Bonner, A., Bryant AO, R., Buzzacott, C., Campbell, S., Catling, C., Chamberlain, C., Cox, L., Cross, W., Cruickshank, M., Cummins, A., Dahlen, H., Daly, J., Darbyshire, P., Davidson, P., Denney-Wilson, E., de Souza, R., Doyle, K., Drummond, A., Duff, J., Duffield, C., Dunning, T., East, L., Elliott, D., Elmir, R., Fergie OAM, D., Ferguson, C., Fernandez, R., Flower AM, D., Foureur, M., Fowler, C., Fry, M., Gorman, E., Grant, J., Gray, J., Halcomb, E., Hart, B., Hartz, D., Hazelton, M., Heaton, L., Hickman, L., Homer AO, C. S. E., Hungerford, C., Hutton, A., Jackson AO, D., Johnson, A., Kelly, M.A., Kitson, A., Knight, S., Levett-Jones, T., Lindsay, D., Lovett, R., Luck, L., Molloy, L., Manias, E., Mannix, J., Marriott, R., Martin, M., Massey, D., McCloughen, A., McGough, S., McGrath, L., Mills, J., Mitchell, B. G., Mohamed, J., Montayre, J., Moroney, T., Moyle, W., Moxham, L., Northam OAM, H., Nowlan, S., O'Brien, A. P., Ogunsiji, O., Paterson, C., Pennington, K., Peters, K., Phillips, J., Power, T., Procter, N., Ramjan, L., Ramsay, N., Rasmussen, B., Rihari-Thomas, J., Rind, B., Robinson, M., Roche, M., Sainsbury, K., Salamonson, Y., Sherwood, J., Shields, L., Sim, J., Skinner, I., Smallwood, G., Smallwood, R., Stewart, L., Taylor, S., Usher AM, K., Virdun, C., Wannell, J., Ward, R., West, C., West, R., Wilkes, L., Williams, R., Wilson, R., Wynaden, D., Wynne, R., Geia, L., Baird, K., Bail, K., Barclay, L., Bennett, J., Best, O., Birks, M., Blackley, L., Blackman, R., Bonner, A., Bryant AO, R., Buzzacott, C., Campbell, S., Catling, C., Chamberlain, C., Cox, L., Cross, W., Cruickshank, M., Cummins, A., Dahlen, H., Daly, J., Darbyshire, P., Davidson, P., Denney-Wilson, E., de Souza, R., Doyle, K., Drummond, A., Duff, J., Duffield, C., Dunning, T., East, L., Elliott, D., Elmir, R., Fergie OAM, D., Ferguson, C., Fernandez, R., Flower AM, D., Foureur, M., Fowler, C., Fry, M., Gorman, E., Grant, J., Gray, J., Halcomb, E., Hart, B., Hartz, D., Hazelton, M., Heaton, L., Hickman, L., Homer AO, C. S. E., Hungerford, C., Hutton, A., Jackson AO, D., Johnson, A., Kelly, M.A., Kitson, A., Knight, S., Levett-Jones, T., Lindsay, D., Lovett, R., Luck, L., Molloy, L., Manias, E., Mannix, J., Marriott, R., Martin, M., Massey, D., McCloughen, A., McGough, S., McGrath, L., Mills, J., Mitchell, B. G., Mohamed, J., Montayre, J., Moroney, T., Moyle, W., Moxham, L., Northam OAM, H., Nowlan, S., O'Brien, A. P., Ogunsiji, O., Paterson, C., Pennington, K., Peters, K., Phillips, J., Power, T., Procter, N., Ramjan, L., Ramsay, N., Rasmussen, B., Rihari-Thomas, J., Rind, B., Robinson, M., Roche, M., Sainsbury, K., Salamonson, Y., Sherwood, J., Shields, L., Sim, J., Skinner, I., Smallwood, G., Smallwood, R., Stewart, L., Taylor, S., Usher AM, K., Virdun, C., Wannell, J., Ward, R., West, C., West, R., Wilkes, L., Williams, R., Wilson, R., Wynaden, D., and Wynne, R.

Abstract

Nurses and midwives of Australia now is the time for change! As powerfully placed, Indigenous and non-Indigenous nursing and midwifery professionals, together we can ensure an effective and robust Indigenous curriculum in our nursing and midwifery schools of education. Today, Australia finds itself in a shifting tide of social change, where the voices for better and safer health care ring out loud. Voices for justice, equity and equality reverberate across our cities, our streets, homes, and institutions of learning. It is a call for new songlines of reform. The need to embed meaningful Indigenous health curricula is stronger now than it ever was for Australian nursing and midwifery. It is essential that nursing and midwifery leadership continue to build an authentic collaborative environment for Indigenous curriculum development. Bipartisan alliance is imperative for all academic staff to be confident in their teaching and learning experiences with Indigenous health syllabus. This paper is a call out. Now is the time for Indigenous and non-Indigenous nurses and midwives to make a stand together, for justice and equity in our teaching, learning, and practice. Together we will dismantle systems, policy, and practices in health that oppress. The Black Lives Matter movement provides us with a ‘now window’ of accepted dialogue to build a better, culturally safe Australian nursing and midwifery workforce, ensuring that Black Lives Matter in all aspects of health care.

Published
2020

16. A unified call to action from Australian nursing and midwifery leaders: Ensuring that Black lives matter

Author

Geia, Lynore, Baird, K., Bail, K., Barclay, L., Bennett, J., Best, O., Birks, M., Blackley, L., Blackman, R., Bonner, A., Bryant AO, R., Buzzacott, C., Campbell, S., Catling, C., Chamberlain, C., Cox, L., Cross, W., Cruickshank, M., Cummins, A., Dahlen, H., Daly, J., Darbyshire, P., Davidson, P., Denney-Wilson, E., De Souza, R., Doyle, K., Drummond, A., Duff, J., Duffield, Christine M, Dunning, T., East, L., Elliott, D., Elmir, R., Fergie, D., Ferguson, C., Fernandez, R., Flower, D., Foureur, M., Fowler, C., Fry, M., Gorman, E., Grant, J., Gray, J., Halcomb, E., Hart, B., Hartz, D., Hazelton, M., Heaton, L., Hickman, L., Homer, C. S. E., Hungerford, C., Hutton, A., Jackson, D., Johnson, A., Kelly, M. A., Kitson, A., Knight, S., Levett-Jones, T., Lindsay, D., Lovett, R., Luck, L., Molloy, L., Manias, E., Mannix, J., Marriott, A.M.R., Martin, M., Massey, D., McCloughen, A., McGough, S., McGrath, L., Mills, J., Mitchell, B. G., Mohamed, J., Montayre, J., Moroney, T., Moyle, W., Moxham, L., Northam, H., Nowlan, S., O'Brien, A. P., Ogunsiji, O., Paterson, C., Pennington, K., Peters, K., Philips, J., Power, T., Procter, N., Ramjan, L., Ramsay, N., Rasmussen, B., Rihari-Thomas, J., Rind, B., Robinson, M., Roche, M., Sainsbury, K., Salamonson, Y., Sherwood, J., Shields, L., Sim, J., Skinner, I., Smallwood, G., Smallwood, R., Stewart, L., Taylor, S., Usher, K., Virdun, C., Wannell, J., Ward, R., West, C., West, R., Wilkes, L., Williams, R., Wilson, R., Wynaden, D., Wynne, R., Geia, Lynore, Baird, K., Bail, K., Barclay, L., Bennett, J., Best, O., Birks, M., Blackley, L., Blackman, R., Bonner, A., Bryant AO, R., Buzzacott, C., Campbell, S., Catling, C., Chamberlain, C., Cox, L., Cross, W., Cruickshank, M., Cummins, A., Dahlen, H., Daly, J., Darbyshire, P., Davidson, P., Denney-Wilson, E., De Souza, R., Doyle, K., Drummond, A., Duff, J., Duffield, Christine M, Dunning, T., East, L., Elliott, D., Elmir, R., Fergie, D., Ferguson, C., Fernandez, R., Flower, D., Foureur, M., Fowler, C., Fry, M., Gorman, E., Grant, J., Gray, J., Halcomb, E., Hart, B., Hartz, D., Hazelton, M., Heaton, L., Hickman, L., Homer, C. S. E., Hungerford, C., Hutton, A., Jackson, D., Johnson, A., Kelly, M. A., Kitson, A., Knight, S., Levett-Jones, T., Lindsay, D., Lovett, R., Luck, L., Molloy, L., Manias, E., Mannix, J., Marriott, A.M.R., Martin, M., Massey, D., McCloughen, A., McGough, S., McGrath, L., Mills, J., Mitchell, B. G., Mohamed, J., Montayre, J., Moroney, T., Moyle, W., Moxham, L., Northam, H., Nowlan, S., O'Brien, A. P., Ogunsiji, O., Paterson, C., Pennington, K., Peters, K., Philips, J., Power, T., Procter, N., Ramjan, L., Ramsay, N., Rasmussen, B., Rihari-Thomas, J., Rind, B., Robinson, M., Roche, M., Sainsbury, K., Salamonson, Y., Sherwood, J., Shields, L., Sim, J., Skinner, I., Smallwood, G., Smallwood, R., Stewart, L., Taylor, S., Usher, K., Virdun, C., Wannell, J., Ward, R., West, C., West, R., Wilkes, L., Williams, R., Wilson, R., Wynaden, D., and Wynne, R.

Abstract

© 2020 Informa UK Limited, trading as Taylor & Francis Group. Nurses and midwives of Australia now is the time for change! As powerfully placed, Indigenous and non-Indigenous nursing and midwifery professionals, together we can ensure an effective and robust Indigenous curriculum in our nursing and midwifery schools of education. Today, Australia finds itself in a shifting tide of social change, where the voices for better and safer health care ring out loud. Voices for justice, equity and equality reverberate across our cities, our streets, homes, and institutions of learning. It is a call for new songlines of reform. The need to embed meaningful Indigenous health curricula is stronger now than it ever was for Australian nursing and midwifery. It is essential that nursing and midwifery leadership continue to build an authentic collaborative environment for Indigenous curriculum development. Bipartisan alliance is imperative for all academic staff to be confident in their teaching and learning experiences with Indigenous health syllabus. This paper is a call out. Now is the time for Indigenous and non-Indigenous nurses and midwives to make a stand together, for justice and equity in our teaching, learning, and practice. Together we will dismantle systems, policy, and practices in health that oppress. The Black Lives Matter movement provides us with a ‘now window’ of accepted dialogue to build a better, culturally safe Australian nursing and midwifery workforce, ensuring that Black Lives Matter in all aspects of health care.

Published
2020

17. A unified call to action from Australian nursing and midwifery leaders: ensuring that Black lives matter

Author

Geia, L, Baird, K, Bail, K, Barclay, Lesley M, Bennett, James E, Best, O, Birks, M, Blackley, L, Blackman, R, Bonner, A, Bryant, R, Buzzacott, C, Campbell, S, Catling, Christine, Chamberlain, C, Cox, L, Cross, W, Cruickshank, M, Cummins, A, Dahlen, H, Daly, J, Darbyshire, Philip, Davidson, Patricia M, Denney-Wilson, Elizabeth, De Souza, R, Doyle, K, Drummond, A, Duff, J, Duffield, C, Dunning, T, East, Leah, Elliott, D, Elmir, R, Fergie, D, Ferguson, Caleb, Fernandez, Ritin S, Flower, D, Foureur, M, Fowler, Cathrine, Fry, M, Gorman, E, Grant, J, Gray, Joanne, Halcomb, Elizabeth J, Hart, B, Hartz, D, Hazelton, M, Heaton, L, Hickman, Louise, Homer, C, Hungerford, C, Hutton, A, Jackson, Debra, Johnson, A, Kelly, Margaret, Kitson, A, Knight, S, Levett-Jones, Tracy, Lindsay, D, Lovett, Raymond W, Luck, Lauretta, Molloy, Luke J, Manias, E, Mannix, Judy, Marriott, A, Martin, M, Massey, D, McCloughen, Andrea, McGough, S, McGrath, L, Mills, J, Mitchell, Brett, Mohamed, J, Montayre, J, Moroney, Tracey, Moyle, Wendy, Moxham, Lorna, Northam, H, Nowlan, S, O'Brien, A, Ogunsiji, O, Paterson, C, Pennington, K, Peters, Kathleen, Phillips, Jane, Power, Tamara, Procter, Nicholas, Ramjan, Lucie, Ramsay, N, Rasmussen, B, Rihari-Thomas, J, Rind, B, Robinson, M, Roche, Michael, Sainsbury, K, Salamonson, Yenna, Sherwood, J, Shields, L, Sim, Jenny, Skinner, J, Smallwood, G, Smallwood, R, Stewart, L, Taylor, S, Usher, K, Virdun, C, Wannell, J, Ward, R, West, C, West, R, Wilkes, Lesley, Williams, R, Wilson, Rhonda, Wynaden, D, Wynne, R, Geia, L, Baird, K, Bail, K, Barclay, Lesley M, Bennett, James E, Best, O, Birks, M, Blackley, L, Blackman, R, Bonner, A, Bryant, R, Buzzacott, C, Campbell, S, Catling, Christine, Chamberlain, C, Cox, L, Cross, W, Cruickshank, M, Cummins, A, Dahlen, H, Daly, J, Darbyshire, Philip, Davidson, Patricia M, Denney-Wilson, Elizabeth, De Souza, R, Doyle, K, Drummond, A, Duff, J, Duffield, C, Dunning, T, East, Leah, Elliott, D, Elmir, R, Fergie, D, Ferguson, Caleb, Fernandez, Ritin S, Flower, D, Foureur, M, Fowler, Cathrine, Fry, M, Gorman, E, Grant, J, Gray, Joanne, Halcomb, Elizabeth J, Hart, B, Hartz, D, Hazelton, M, Heaton, L, Hickman, Louise, Homer, C, Hungerford, C, Hutton, A, Jackson, Debra, Johnson, A, Kelly, Margaret, Kitson, A, Knight, S, Levett-Jones, Tracy, Lindsay, D, Lovett, Raymond W, Luck, Lauretta, Molloy, Luke J, Manias, E, Mannix, Judy, Marriott, A, Martin, M, Massey, D, McCloughen, Andrea, McGough, S, McGrath, L, Mills, J, Mitchell, Brett, Mohamed, J, Montayre, J, Moroney, Tracey, Moyle, Wendy, Moxham, Lorna, Northam, H, Nowlan, S, O'Brien, A, Ogunsiji, O, Paterson, C, Pennington, K, Peters, Kathleen, Phillips, Jane, Power, Tamara, Procter, Nicholas, Ramjan, Lucie, Ramsay, N, Rasmussen, B, Rihari-Thomas, J, Rind, B, Robinson, M, Roche, Michael, Sainsbury, K, Salamonson, Yenna, Sherwood, J, Shields, L, Sim, Jenny, Skinner, J, Smallwood, G, Smallwood, R, Stewart, L, Taylor, S, Usher, K, Virdun, C, Wannell, J, Ward, R, West, C, West, R, Wilkes, Lesley, Williams, R, Wilson, Rhonda, Wynaden, D, and Wynne, R

Abstract

Nurses and midwives of Australia now is the time for change! As powerfully placed, Indigenous and non-Indigenous nursing and midwifery professionals, together we can ensure an effective and robust Indigenous curriculum in our nursing and midwifery schools of education. Today, Australia finds itself in a shifting tide of social change, where the voices for better and safer health care ring out loud. Voices for justice, equity and equality reverberate across our cities, our streets, homes, and institutions of learning. It is a call for new songlines of reform. The need to embed meaningful Indigenous health curricula is stronger now than it ever was for Australian nursing and midwifery. It is essential that nursing and midwifery leadership continue to build an authentic collaborative environment for Indigenous curriculum development. Bipartisan alliance is imperative for all academic staff to be confident in their teaching and learning experiences with Indigenous health syllabus. This paper is a call out. Now is the time for Indigenous and non-Indigenous nurses and midwives to make a stand together, for justice and equity in our teaching, learning, and practice. Together we will dismantle systems, policy, and practices in health that oppress. The Black Lives Matter movement provides us with a ‘now window’ of accepted dialogue to build a better, culturally safe Australian nursing and midwifery workforce, ensuring that Black Lives Matter in all aspects of health care.

Published
2020

18. A unified call to action from Australian nursing and midwifery leaders: ensuring that Black lives matter

Author

Geia, L., primary, Baird, K., additional, Bail, K., additional, Barclay, L., additional, Bennett, J., additional, Best, O., additional, Birks, M., additional, Blackley, L., additional, Blackman, R., additional, Bonner, A., additional, Bryant AO, R., additional, Buzzacott, C., additional, Campbell, S., additional, Catling, C., additional, Chamberlain, C., additional, Cox, L., additional, Cross, W., additional, Cruickshank, M., additional, Cummins, A., additional, Dahlen, H., additional, Daly, J., additional, Darbyshire, P., additional, Davidson, P., additional, Denney-Wilson, E., additional, De Souza, R., additional, Doyle, K., additional, Drummond, A., additional, Duff, J., additional, Duffield, C., additional, Dunning, T., additional, East, L., additional, Elliott, D., additional, Elmir, R., additional, Fergie OAM, D., additional, Ferguson, C., additional, Fernandez, R., additional, Flower AM, D., additional, Foureur, M., additional, Fowler, C., additional, Fry, M., additional, Gorman, E., additional, Grant, J., additional, Gray, J., additional, Halcomb, E., additional, Hart, B., additional, Hartz, D., additional, Hazelton, M., additional, Heaton, L., additional, Hickman, L., additional, Homer AO, C. S. E., additional, Hungerford, C., additional, Hutton, A., additional, Jackson AO, D., additional, Johnson, A., additional, Kelly, M. A., additional, Kitson, A., additional, Knight, S., additional, Levett-Jones, T., additional, Lindsay, D., additional, Lovett, R., additional, Luck, L., additional, Molloy, L., additional, Manias, E., additional, Mannix, J., additional, Marriott, A. M. R., additional, Martin, M., additional, Massey, D., additional, McCloughen, A., additional, McGough, S., additional, McGrath, L., additional, Mills, J., additional, Mitchell, B. G., additional, Mohamed, J., additional, Montayre, J., additional, Moroney, T., additional, Moyle, W., additional, Moxham, L., additional, Northam OAM, H., additional, Nowlan, S., additional, O'Brien, A. P., additional, Ogunsiji, O., additional, Paterson, C., additional, Pennington, K., additional, Peters, K., additional, Phillips, J., additional, Power, T., additional, Procter, N., additional, Ramjan, L., additional, Ramsay, N., additional, Rasmussen, B., additional, Rihari-Thomas, J., additional, Rind, B., additional, Robinson, M., additional, Roche, M., additional, Sainsbury, K., additional, Salamonson, Y., additional, Sherwood, J., additional, Shields, L., additional, Sim, J., additional, Skinner, I., additional, Smallwood, G., additional, Smallwood, R., additional, Stewart, L., additional, Taylor, S., additional, Usher AM, K., additional, Virdun, C., additional, Wannell, J., additional, Ward, R., additional, West, C., additional, West, R., additional, Wilkes, L., additional, Williams, R., additional, Wilson, R., additional, Wynaden, D., additional, and Wynne, R., additional

Published
2020
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28. From Possibility to Action: An Interdisciplinary Action-Learning School dealing with Waste

Author

Lambert-Pennington, K, Saija, L, and Franchina, A

Subjects
Social sciences (General), H1-99, Action-learning, Zero waste, Sicily, Sociology (General), HM401-1281
Abstract

For more than a decade, researchers and activists have collaborated in the Simeto Valley for the advancement of development inspired by social solidarity and the need of reconnecting people to the local ecosystem. Over time, this experiment has progressively turned into an interdisciplinary action research partnership that involves now mainly planners and anthropologists. One of the activities carried out in the Valley is an action-learning Summer School organized by the University of Memphis in partnership with the University of Massachussets, Boston and the University of Catania. The work of this partnership lies between planning and anthropology and has generated an interdisciplinary space and a shared methodology of action-learning. This methodology is neither exclusively inductive nor used as a basis for deduction, but modified in the course of collective action. This paper describes the theoretical and pedagogical principles underlying CoPED and draws on its 2017 edition, which focused on Zero Waste, to show how it provides a platform for theory-in-action., Cambio. Rivista sulle Trasformazioni Sociali, Vol. 8 No. 15 (2018): Another World is Possible. Collaborate to Transform

Published
2018

40. A proteomic investigation of similarities between conventional and herbal antidepressant treatments

Author

Pennington, K., Focking, M., McManus, C.A., Pariante, C.M., Dunn, M.J., and Cotter, D.R.

Subjects
Clomipramine -- Usage, Clomipramine -- Health aspects, Gel electrophoresis -- Usage, Mass spectrometry -- Usage, Affective disorders -- Diagnosis, Affective disorders -- Drug therapy, Neuroplasticity -- Research, Pharmaceuticals and cosmetics industries, Psychology and mental health
Published
2009

46. Temporal Patterns of Influenza A and B in Tropical and Temperate Countries: What Are the Lessons for Influenza Vaccination?

Author

Caini, S., Andrade, W., Badur, S., Balmaseda, A., Barakat, A., Bella, A., Bimohuen, A., Brammer, L., Bresee, J., Bruno, A., Castillo, L., Ciblak, M.A., Clara, A.W., Cohen, C., Cutter, J., Daouda, C., Lozano, C., Mora, D. De, Dorji, K., Emukule, G.O., Fasce, R.A., Feng, L., Ferreira de Almeida, W.A., Guiomar, R., Heraud, J.M., Holubka, O., Huang, Q.S., Kadjo, H.A., Kiyanbekova, L., Kosasih, H., Kusznierz, G., Lara, J., Li, M., Lopez, L., Mai Hoang, P.V., Henriques, C.M., Matute, M.L., Mironenko, A., Moreno, B., Mott, J.A., Njouom, R., Nurhayati, ., Ospanova, A., Owen, R., Pebody, R., Pennington, K., Puzelli, S., Quynh Le, M.T., Razanajatovo, N.H., Rodrigues, A., Rudi, J.M., Lin, R., Venter, M., Vernet, M.A., Wangchuk, S., Yang, J., Yu, H., Zambon, M., Schellevis, F., Paget, J., Caini, S., Andrade, W., Badur, S., Balmaseda, A., Barakat, A., Bella, A., Bimohuen, A., Brammer, L., Bresee, J., Bruno, A., Castillo, L., Ciblak, M.A., Clara, A.W., Cohen, C., Cutter, J., Daouda, C., Lozano, C., Mora, D. De, Dorji, K., Emukule, G.O., Fasce, R.A., Feng, L., Ferreira de Almeida, W.A., Guiomar, R., Heraud, J.M., Holubka, O., Huang, Q.S., Kadjo, H.A., Kiyanbekova, L., Kosasih, H., Kusznierz, G., Lara, J., Li, M., Lopez, L., Mai Hoang, P.V., Henriques, C.M., Matute, M.L., Mironenko, A., Moreno, B., Mott, J.A., Njouom, R., Nurhayati, ., Ospanova, A., Owen, R., Pebody, R., Pennington, K., Puzelli, S., Quynh Le, M.T., Razanajatovo, N.H., Rodrigues, A., Rudi, J.M., Lin, R., Venter, M., Vernet, M.A., Wangchuk, S., Yang, J., Yu, H., Zambon, M., Schellevis, F., and Paget, J.

Abstract

Contains fulltext : 171632.PDF (publisher's version ) (Open Access), INTRODUCTION: Determining the optimal time to vaccinate is important for influenza vaccination programmes. Here, we assessed the temporal characteristics of influenza epidemics in the Northern and Southern hemispheres and in the tropics, and discuss their implications for vaccination programmes. METHODS: This was a retrospective analysis of surveillance data between 2000 and 2014 from the Global Influenza B Study database. The seasonal peak of influenza was defined as the week with the most reported cases (overall, A, and B) in the season. The duration of seasonal activity was assessed using the maximum proportion of influenza cases during three consecutive months and the minimum number of months with >/=80% of cases in the season. We also assessed whether co-circulation of A and B virus types affected the duration of influenza epidemics. RESULTS: 212 influenza seasons and 571,907 cases were included from 30 countries. In tropical countries, the seasonal influenza activity lasted longer and the peaks of influenza A and B coincided less frequently than in temperate countries. Temporal characteristics of influenza epidemics were heterogeneous in the tropics, with distinct seasonal epidemics observed only in some countries. Seasons with co-circulation of influenza A and B were longer than influenza A seasons, especially in the tropics. DISCUSSION: Our findings show that influenza seasonality is less well defined in the tropics than in temperate regions. This has important implications for vaccination programmes in these countries. High-quality influenza surveillance systems are needed in the tropics to enable decisions about when to vaccinate.

Published
2016

50. Dietary Energy Restriction Inhibits Estrogen-Induced Mammary Carcinogenesis in the Female ACI Rat

Author

Strecker, T. E., Xie, B., Pennington, K. L., McComb, R. D., and Schull, J. D.

Subjects
Carcinogenesis -- Physiological aspects, Rats -- Physiological aspects, Breast cancer -- Research, Estrogen -- Physiological aspects, Low-calorie diet -- Physiological aspects, Progesterone -- Receptors, Epithelium -- Physiological aspects, Food/cooking/nutrition
Abstract

The female ACI rat is a unique and physiologically relevant animal model for the study of breast cancer etiology in that it is highly susceptible to the development of estrogen-induced mammary cancer but rarely develops mammary cancer spontaneously. Data from our laboratory indicate that the genetic basis of the susceptibility of the ACI rat to estrogen-induced mammary cancer development is distinct from the more widely used dimethyl-benz[a]anthracene-induced mammary cancer model. It is well established that dietary energy restriction inhibits carcinogen-induced mammary carcinogenesis in rodents. However, the effect of dietary energy restriction on estrogen-induced mammary cancer development has yet to be determined. The purpose of the present study was to investigate whether dietary energy restriction inhibits mammary carcinogenesis induced by 17beta-estradiol ([E.sub.2]) in female ACI rats. To test this hypothesis, we examined the incidence of mammary tumors and precancerous lesions in [E.sub.2]-treated female ACI rats fed a 40% energy-restricted diet. The effects of dietary energy restriction and estrogen on mammary tumor latency, multiplicity and size were also examined. To address the mechanisms through which dietary energy restriction might exert its inhibitory effects on [E.sub.2]-induced mammary cancer development, we examined progesterone receptor expression and cell proliferation in the mammary epithelium of [E.sub.2]-treated rats fed the energy-restricted diet. The data presented indicate that dietary energy restriction inhibits [E.sub.2]-induced mammary cancer development in female ACI rats apparently by inhibiting the progression of precursor lesions into carcinomas. The potential involvement of progesterone receptor expression and mammary cell proliferation in the ability of dietary energy restriction to inhibit [E.sub.2]-induced mammary carcinogenesis is also discussed. [Supported by grant 97A146 from the American Institute for Cancer Research and grants CA68529 and CA77876 from National Institutes of Health.]

Published
2001

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