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719 results on '"Penna, Claudia"'

1. An intrinsic mechanism of metabolic tuning promotes cardiac resilience to stress

Author

Sorge, Matteo, Savoré, Giulia, Gallo, Andrea, Acquarone, Davide, Sbroggiò, Mauro, Velasco, Silvia, Zamporlini, Federica, Femminò, Saveria, Moiso, Enrico, Morciano, Giampaolo, Balmas, Elisa, Raimondi, Andrea, Nattenberg, Gabrielle, Stefania, Rachele, Tacchetti, Carlo, Rizzo, Angela Maria, Corsetto, Paola, Ghigo, Alessandra, Turco, Emilia, Altruda, Fiorella, Silengo, Lorenzo, Pinton, Paolo, Raffaelli, Nadia, Sniadecki, Nathan J, Penna, Claudia, Pagliaro, Pasquale, Hirsch, Emilio, Riganti, Chiara, Tarone, Guido, Bertero, Alessandro, and Brancaccio, Mara

Published
2024
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3. Discovery of a novel 1,3,4-oxadiazol-2-one-based NLRP3 inhibitor as a pharmacological agent to mitigate cardiac and metabolic complications in an experimental model of diet-induced metaflammation

Author

Gastaldi, Simone, Rocca, Carmine, Gianquinto, Eleonora, Granieri, Maria Concetta, Boscaro, Valentina, Blua, Federica, Rolando, Barbara, Marini, Elisabetta, Gallicchio, Margherita, De Bartolo, Anna, Romeo, Naomi, Mazza, Rosa, Fedele, Francesco, Pagliaro, Pasquale, Penna, Claudia, Spyrakis, Francesca, Bertinaria, Massimo, and Angelone, Tommaso

Subjects
Physics - Biological Physics, Physics - Medical Physics
Abstract

Inspired by the recent advancements in understanding the binding mode of sulfonylurea-based NLRP3 inhibitors to the NLRP3 sensor protein, we developed new NLRP3 inhibitors by replacing the central sulfonylurea moiety with different heterocycles. Computational studies evidenced that some of the designed compounds were able to maintain important interaction within the NACHT domain of the target protein similarly to the most active sulfonylurea-based NLRP3 inhibitors. Among the studied compounds, the 1,3,4-oxadiazol-2-one derivative 5 (INF200) showed the most promising results being able to prevent NLRP3-dependent pyroptosis triggered by LPS/ATP and LPS/MSU by 66.3 +/- 6.6% and 61.6 +/- 11.5% and to reduce IL-1\b{eta} release (35.5 +/- 8.8 % {\mu}M) at 10 {\mu}M in human macrophages. The selected compound INF200 (20 mg/kg/day) was then tested in an in vivo rat model of high-fat diet (HFD)-induced metaflammation to evaluate its beneficial cardiometabolic effects. INF200 significantly counteracted HFD-dependent "anthropometric" changes, improved glucose and lipid profiles, and attenuated systemic inflammation and biomarkers of cardiac dysfunction (particularly BNP). Hemodynamic evaluation on Langendorff model indicate that INF200 limited myocardial damage-dependent ischemia/reperfusion injury (IRI) by improving post-ischemic systolic recovery and attenuating cardiac contracture, infarct size, and LDH release, thus reversing the exacerbation of obesity-associated damage. Mechanistically, in post-ischemic hearts, IFN200 reduced IRI-dependent NLRP3 activation, inflammation, and oxidative stress. These results highlight the potential of the novel NLRP3 inhibitor, INF200, and its ability to reverse the unfavorable cardio-metabolic dysfunction associated with obesity.

Published
2023

29. Enhancing Heart Transplantation: Utilizing Gas-Loaded Nanocarriers to Mitigate Cold/Hypoxia Stress

Author

Rubeo, Chiara, primary, Hoti, Gjylije, additional, Giordano, Magalì, additional, Molinar, Chiara, additional, Aragno, Manuela, additional, Mantuano, Beatrice, additional, Comità, Stefano, additional, Femminò, Saveria, additional, Cavalli, Roberta, additional, Trotta, Francesco, additional, Penna, Claudia, additional, and Pagliaro, Pasquale, additional

Published
2024
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36. Management of cancer patients at high and very-high risk of cardiotoxicity: main questions and answers

Author

Lisi, Daniela Di, primary, Dessalvi, Christian Cadeddu, additional, Zito, Concetta, additional, Madaudo, Cristina, additional, Manganaro, Roberta, additional, Mercurio, Valentina, additional, Deidda, Martino, additional, Santoro, Ciro, additional, Penna, Claudia, additional, Monte, Ines Paola, additional, Spallarossa, Paolo, additional, Tocchetti, Carlo Gabriele, additional, and Novo, Giuseppina, additional

Published
2023
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38. Discovery of a novel 1,3,4-oxadiazol-2-one-based NLRP3 inhibitor as a pharmacological agent to mitigate cardiac and metabolic complications in an experimental model of diet-induced metaflammation

Author

Gastaldi, Simone, primary, Rocca, Carmine, additional, Gianquinto, Eleonora, additional, Granieri, Maria Concetta, additional, Boscaro, Valentina, additional, Blua, Federica, additional, Rolando, Barbara, additional, Marini, Elisabetta, additional, Gallicchio, Margherita, additional, De Bartolo, Anna, additional, Romeo, Naomi, additional, Mazza, Rosa, additional, Fedele, Francesco, additional, Pagliaro, Pasquale, additional, Penna, Claudia, additional, Spyrakis, Francesca, additional, Bertinaria, Massimo, additional, and Angelone, Tommaso, additional

Published
2023
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41. Chromogranin A-Derived Peptides in Cardiac Pre- and Post-conditioning

Author

Penna, Claudia, Pagliaro, Pasquale, Amenta, Carlo, Editor-in-chief, Bavetta, Sebastiano, Series editor, Caruso, Calogero, Series editor, Lavanco, Gioacchino, Series editor, Maresca, Bruno, Series editor, Öchsner, Andreas, Series editor, Piva, Mariacristina, Series editor, Pozzi Mucelli, Roberto, Series editor, Restivo, Antonio, Series editor, Seel, Norbert M., Series editor, Viviani, Gaspare, Series editor, Angelone, Tommaso, editor, Cerra, Maria Carmela, editor, and Tota, Bruno, editor

Published
2017
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43. Growth hormone-releasing hormone attenuates cardiac hypertrophy and improves heart function in pressure overload-induced heart failure

Author

Gesmundo, Iacopo, Miragoli, Michele, Carullo, Pierluigi, Trovato, Letizia, Larcher, Veronica, Di Pasquale, Elisa, Brancaccio, Mara, Mazzola, Marta, Villanova, Tania, Sorge, Matteo, Taliano, Marina, Gallo, Maria Pia, Alloatti, Giuseppe, Penna, Claudia, Hare, Joshua M., Ghigo, Ezio, Schally, Andrew V., Condorelli, Gianluigi, and Granata, Riccarda

Published
2017

47. Enhancing Vitamin D3 Efficacy: Insights from Complexation with Cyclodextrin Nanosponges and Its Impact on Gut–Brain Axes in Physiology and IBS Syndrome.

Author

Uberti, Francesca, Trotta, Francesco, Cavalli, Roberta, Galla, Rebecca, Caldera, Fabrizio, Ferrari, Sara, Mulè, Simone, Brovero, Arianna, Molinari, Claudio, Pagliaro, Pasquale, and Penna, Claudia

Subjects
CHOLECALCIFEROL, CYCLODEXTRINS, CELL physiology, PHYSIOLOGY, TIGHT junctions, OCCLUDINS, CLAUDINS
Abstract

Vitamin D3 (VitD3) plays a crucial role in various cellular functions through its receptor interaction. The biological activity of Vitamin D3 can vary based on its solubility and stability. Thus, the challenge lies in maximizing its biological effects through its complexation within cyclodextrin (βNS-CDI 1:4) nanosponges (NS) (defined as VitD3NS). Therefore, its activity has been evaluated on two different gut–brain axes (healthy gut/degenerative brain and inflammatory bowel syndrome gut/degenerative brain axis). At the gut level, VitD3-NS mitigated liposaccharide-induced damage (100 ng/mL; for 48 h), restoring viability, integrity, and activity of tight junctions and reducing ROS production, lipid peroxidation, and cytokines levels. Following intestinal transit, VitD3-NS improved the neurodegenerative condition in the healthy axis and the IBS model, suggesting the ability of VitD3-NS to preserve efficacy and beneficial effects even in IBS conditions. In conclusion, this study demonstrates the ability of this novel form of VitD3, named VitD3-NS, to act on the gut–brain axis in healthy and damaged conditions, emphasizing enhanced biological activity through VitD3 complexation, as such complexation increases the beneficial effect of vitamin D3 in both the gut and brain by about 50%. [ABSTRACT FROM AUTHOR]

Published
2024
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