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12 results on '"Penington, Jocelyn Sietsma"'

1. A G358S mutation in the Plasmodium falciparum Na+ pump PfATP4 confers clinically-relevant resistance to cipargamin

Author

Qiu, Deyun, Pei, Jinxin V., Rosling, James E. O., Thathy, Vandana, Li, Dongdi, Xue, Yi, Tanner, John D., Penington, Jocelyn Sietsma, Aw, Yi Tong Vincent, Aw, Jessica Yi Han, Xu, Guoyue, Tripathi, Abhai K., Gnadig, Nina F., Yeo, Tomas, Fairhurst, Kate J., Stokes, Barbara H., Murithi, James M., Kümpornsin, Krittikorn, Hasemer, Heath, Dennis, Adelaide S. M., Ridgway, Melanie C., Schmitt, Esther K., Straimer, Judith, Papenfuss, Anthony T., Lee, Marcus C. S., Corry, Ben, Sinnis, Photini, Fidock, David A., van Dooren, Giel G., Kirk, Kiaran, and Lehane, Adele M.

Published
2022
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2. A 4-cyano-3-methylisoquinoline inhibitor of Plasmodium falciparum growth targets the sodium efflux pump PfATP4

Author

Gilson, Paul R., Kumarasingha, Rasika, Thompson, Jennifer, Zhang, Xinxin, Penington, Jocelyn Sietsma, Kalhor, Robabeh, Bullen, Hayley E., Lehane, Adele M., Dans, Madeline G., de Koning-Ward, Tania F., Holien, Jessica K., Soares da Costa, Tatiana P., Hulett, Mark D., Buskes, Melissa J., Crabb, Brendan S., Kirk, Kiaran, Papenfuss, Anthony T., Cowman, Alan F., and Abbott, Belinda M.

Published
2019
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3. Type 1 diabetes: a disease of developmental origins

Author

Phillips, Jessica E., Couper, Jennifer J., Penno, Megan A.S., Harrison, Leonard C., Anderson, Heather, Bandala‐Sanchez, Esther, Barry, Simon C, Baskerville, Tracey, Battersby, Rachel, Bediaga, Naiara G, Bezuidenhout, Debra, Brownrigg, Emma, Catteau, Jacki, Choo, Ace, Colman, Peter G, Cotterill, Andrew, Couper, Jennifer J, Craig, Maria E, Curran, Sheryl, Davis, Elizabeth A, Dodd, Jodie M, Edwards, Danielle, French, Jane, Gibson, Emily, Giles, Lynne C, Gwiazdzinski, Alison, Harris, Mark, Harrison, Leonard C, Haynes, Aveni, Hope, Christopher M, Hsieh, Cecilia, Huang, Dexing, Hu, William, Keytash, Azita, Krieg, Meredith, Law, Soi C, Lloyd‐Johnsen, Catherine, Morahan, Grant, Neale, Alana M, Ngui, Katrina, Papenfuss, Anthony T, Penno, Megan AS, Poth, Megan, Ramoso, Benjamin, Rawlinson, William D, Roberts, Alison, Sadlon, Timothy J, Schulze, Alexandra, Penington, Jocelyn Sietsma, Sinnott, Richard O, Spooner, Kelly, Stone, Natalie L, Thomson, Rebecca L, Toome, Sarah, Tully, Alexandra, Vuillermin, Peter J, Watson, Kelly, Wentworth, John M, and Wilson, Julianne

Published
2017
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4. Generation and characterisation of P. falciparum parasites with a G358S mutation in the PfATP4 Na+ pump and clinically relevant levels of resistance to some PfATP4 inhibitors

Author

Qiu, Deyun, primary, Pei, Jinxin V., additional, Rosling, James E. O., additional, Li, Dongdi, additional, Xue, Yi, additional, Penington, Jocelyn Sietsma, additional, Kümpornsin, Krittikorn, additional, Vincent Aw, Yi Tong, additional, Han Aw, Jessica Yi, additional, Hasemer, Heath, additional, Dennis, Adelaide S. M., additional, Ridgway, Melanie C., additional, Papenfuss, Anthony T., additional, Lee, Marcus C. S., additional, van Dooren, Giel G., additional, Kirk, Kiaran, additional, and Lehane, Adele M., additional

Published
2022
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5. A G358S mutation in the Plasmodium falciparum Na+ pump PfATP4 confers clinically-relevant resistance to cipargamin.

Author

Qiu, Deyun, Pei, Jinxin V., Rosling, James E. O., Thathy, Vandana, Li, Dongdi, Xue, Yi, Tanner, John D., Penington, Jocelyn Sietsma, Aw, Yi Tong Vincent, Aw, Jessica Yi Han, Xu, Guoyue, Tripathi, Abhai K., Gnadig, Nina F., Yeo, Tomas, Fairhurst, Kate J., Stokes, Barbara H., Murithi, James M., Kümpornsin, Krittikorn, Hasemer, Heath, and Dennis, Adelaide S. M.

Subjects
PLASMODIUM falciparum, PLASMODIUM, ORAL drug administration, PARASITES, TOXOPLASMA gondii, ADENOSINE triphosphatase
Abstract

Diverse compounds target the Plasmodium falciparum Na+ pump PfATP4, with cipargamin and (+)-SJ733 the most clinically-advanced. In a recent clinical trial for cipargamin, recrudescent parasites emerged, with most having a G358S mutation in PfATP4. Here, we show that PfATP4G358S parasites can withstand micromolar concentrations of cipargamin and (+)-SJ733, while remaining susceptible to antimalarials that do not target PfATP4. The G358S mutation in PfATP4, and the equivalent mutation in Toxoplasma gondii ATP4, decrease the sensitivity of ATP4 to inhibition by cipargamin and (+)-SJ733, thereby protecting parasites from disruption of Na+ regulation. The G358S mutation reduces the affinity of PfATP4 for Na+ and is associated with an increase in the parasite's resting cytosolic [Na+]. However, no defect in parasite growth or transmissibility is observed. Our findings suggest that PfATP4 inhibitors in clinical development should be tested against PfATP4G358S parasites, and that their combination with unrelated antimalarials may mitigate against resistance development. In a recent clinical trial for oral administration of cipargamin in individuals with malaria, there was an emergence of recrudescent parasites with a G358S mutation in PfATP4. In this work, the authors investigate the effect of this mutation on the function of the ATPase, on parasite growth and susceptibility to antimalarial drugs. [ABSTRACT FROM AUTHOR]

Published
2022
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6. Dual Plasmepsin-Targeting Antimalarial Agents Disrupt Multiple Stages of the Malaria Parasite Life Cycle

Author

Favuzza, Paola, primary, de Lera Ruiz, Manuel, additional, Thompson, Jennifer K., additional, Triglia, Tony, additional, Ngo, Anna, additional, Steel, Ryan W.J., additional, Vavrek, Marissa, additional, Christensen, Janni, additional, Healer, Julie, additional, Boyce, Christopher, additional, Guo, Zhuyan, additional, Hu, Mengwei, additional, Khan, Tanweer, additional, Murgolo, Nicholas, additional, Zhao, Lianyun, additional, Penington, Jocelyn Sietsma, additional, Reaksudsan, Kitsanapong, additional, Jarman, Kate, additional, Dietrich, Melanie H., additional, Richardson, Lachlan, additional, Guo, Kai-Yuan, additional, Lopaticki, Sash, additional, Tham, Wai-Hong, additional, Rottmann, Matthias, additional, Papenfuss, Tony, additional, Robbins, Jonathan A., additional, Boddey, Justin A., additional, Sleebs, Brad E., additional, Sabroux, Hélène Jousset, additional, McCauley, John A., additional, Olsen, David B., additional, and Cowman, Alan F., additional

Published
2020
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7. Influence of fecal collection conditions and 16S rRNA gene sequencing at two centers on human gut microbiota analysis

Author

Penington, Jocelyn Sietsma, Penno, Megan AS, Ngui, Katrina M, Ajami, Nadim J, Roth-Schulze, Alexandra J, Wilcox, Stephen A, Bandala-Sanchez, Esther, Wentworth, John M, Barry, Simon C, Brown, Cheryl Y, Couper, Jennifer J, Petrosino, Joseph F, Papenfuss, Anthony T, Harrison, Leonard C, Colman, PG, Cotterill, A, Craig, ME, Davis, EA, Harris, M, Haynes, A, Giles, L, Morahan, G, Morbey, C, Rawlinson, WD, Sinnott, RO, Soldatos, G, Thomson, RL, Vuillermin, Peter, Penington, Jocelyn Sietsma, Penno, Megan AS, Ngui, Katrina M, Ajami, Nadim J, Roth-Schulze, Alexandra J, Wilcox, Stephen A, Bandala-Sanchez, Esther, Wentworth, John M, Barry, Simon C, Brown, Cheryl Y, Couper, Jennifer J, Petrosino, Joseph F, Papenfuss, Anthony T, Harrison, Leonard C, Colman, PG, Cotterill, A, Craig, ME, Davis, EA, Harris, M, Haynes, A, Giles, L, Morahan, G, Morbey, C, Rawlinson, WD, Sinnott, RO, Soldatos, G, Thomson, RL, and Vuillermin, Peter

Abstract

To optimise fecal sampling for reproducible analysis of the gut microbiome, we compared different methods of sample collection and sequencing of 16S rRNA genes at two centers. Samples collected from six individuals on three consecutive days were placed in commercial collection tubes (OMNIgeneGut OMR-200) or in sterile screw-top tubes in a home fridge or home freezer for 6-24 h, before transfer and storage at-80 °C. Replicate samples were shipped to centers in Australia and the USA for DNA extraction and sequencing by their respective PCR protocols, and analysed with the same bioinformatic pipeline. Variation in gut microbiome was dominated by differences between individuals. Minor differences in the abundance of taxa were found between collection-processing methods and day of collection, and between the two centers. We conclude that collection with storage and transport at 4 °C within 24 h is adequate for 16S rRNA analysis of the gut microbiome. Other factors including differences in PCR and sequencing methods account for relatively minor variation compared to differences between individuals.

Published
2018

8. Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors

Author

Sisquella, Xavier, primary, Ofir-Birin, Yifat, additional, Pimentel, Matthew A., additional, Cheng, Lesley, additional, Abou Karam, Paula, additional, Sampaio, Natália G., additional, Penington, Jocelyn Sietsma, additional, Connolly, Dympna, additional, Giladi, Tal, additional, Scicluna, Benjamin J., additional, Sharples, Robyn A., additional, Waltmann, Andreea, additional, Avni, Dror, additional, Schwartz, Eli, additional, Schofield, Louis, additional, Porat, Ziv, additional, Hansen, Diana S., additional, Papenfuss, Anthony T., additional, Eriksson, Emily M., additional, Gerlic, Motti, additional, Hill, Andrew F., additional, Bowie, Andrew G., additional, and Regev-Rudzki, Neta, additional

Published
2017
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10. Influence of fecal collection conditions and 16S rRNA gene sequencing protocols at two centers on human gut microbiota analysis

Author

Penington, Jocelyn Sietsma, primary, Penno, Megan A S, additional, Ngui, Katrina M, additional, Ajami, Nadim J, additional, Roth-Schulze, Alexandra J, additional, Wilcox, Stephen A, additional, Bandala-Sanchez, Esther, additional, Wentworth, John M, additional, Barry, Simon C, additional, Brown, Cheryl Y, additional, Couper, Jennifer J, additional, Petrosino, Joseph F, additional, Papenfuss, Anthony T, additional, and Harrison, Leonard C, additional

Published
2017
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12. Influence of fecal collection conditions and 16S rRNA gene sequencing at two centers on human gut microbiota analysis.

Author

Penington JS, Penno MAS, Ngui KM, Ajami NJ, Roth-Schulze AJ, Wilcox SA, Bandala-Sanchez E, Wentworth JM, Barry SC, Brown CY, Couper JJ, Petrosino JF, Papenfuss AT, and Harrison LC

Subjects
Australia, Cryopreservation methods, Humans, Individuality, RNA, Ribosomal, 16S standards, Sequence Analysis, DNA, United States, Feces microbiology, Gastrointestinal Microbiome genetics, RNA, Ribosomal, 16S genetics, Specimen Handling methods
Abstract

To optimise fecal sampling for reproducible analysis of the gut microbiome, we compared different methods of sample collection and sequencing of 16S rRNA genes at two centers. Samples collected from six individuals on three consecutive days were placed in commercial collection tubes (OMNIgeneGut OMR-200) or in sterile screw-top tubes in a home fridge or home freezer for 6-24 h, before transfer and storage at -80 °C. Replicate samples were shipped to centers in Australia and the USA for DNA extraction and sequencing by their respective PCR protocols, and analysed with the same bioinformatic pipeline. Variation in gut microbiome was dominated by differences between individuals. Minor differences in the abundance of taxa were found between collection-processing methods and day of collection, and between the two centers. We conclude that collection with storage and transport at 4 °C within 24 h is adequate for 16S rRNA analysis of the gut microbiome. Other factors including differences in PCR and sequencing methods account for relatively minor variation compared to differences between individuals.

Published
2018
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