1. A New Polyketide from the Mangrove Endophytic FungusPenicilliumsp. sk14JW2P
- Author
-
Xishan Huang, Lin Ma, Zhigang She, Bin Yang, Xuefeng Sun, Yayue Liu, and Guoping Xia
- Subjects
Penicillium sp. SK14JW2P ,biology ,Stereochemistry ,Chemistry ,Organic Chemistry ,Absolute configuration ,Endophytic fungus ,biology.organism_classification ,Biochemistry ,Catalysis ,Inorganic Chemistry ,Polyketide ,chemistry.chemical_compound ,Drug Discovery ,Penicillium ,Ic50 values ,Physical and Theoretical Chemistry ,Mangrove ,Derivative (chemistry) - Abstract
Two polyketides were isolated from the mangrove endophytic fungus, Penicillium sp. sk14JW2P, and one derivative with a modified structure. The structures were elucidated by spectroscopic analyses, the structure of the compound 1 was further confirmed by single-crystal X-ray diffraction, and its absolute configuration was determined. Compound 1 and 2 showed acetylcholinesterase (AchE) inhibitory activities with IC50 values of 12±0.3 and 79±2 nM, respectively.
- Published
- 2014
- Full Text
- View/download PDF