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To investigate the incidence of skin diseases, the factors affecting the life quality, anxiety, and depression of patients with skin diseases and the correlation among the 3. A total of 1127 patients with skin diseases were selected online from March 2018 to June 2018. Logistic regression was used to analyze the factors influencing life quality, anxiety, and depression. Spearman rank correlation was used to analyze the correction among the life quality, anxiety, and depression. There was no significant difference in ethnicity, education, and time of question among patients (P > .05). Sex ratio, age, marital status, and occupation were statistically significant difference among patients with different skin diseases (P

Melatonin is a crucial neurohormone synthesized in the pineal gland that influences the physiology of animals. The molecular mechanism of norepinephrine control of the synthesis of melatonin is well documented; however, few reports have described the effects of epinephrine on the synthesis of melatonin. In this study, the effect of epinephrine on melatonin synthesis was investigated by adding different concentrations of epinephrine or norepinephrine to broiler pineal glands cultured in vitro. In addition, we investigated how epinephrine regulates the synthesis of melatonin and the transcription of the key melatonin synthesis enzyme AANAT. We determined the abundance of melatonin, norepinephrine, and epinephrine in broiler serum and the mRNA expression levels of key enzymes under different light conditions. The minimum concentrations of epinephrine and norepinephrine required to recover the melatonin synthesis rhythm in pineal cells were 10−13 and 10−11 mol/L, respectively. Under various light durations, epinephrine reached maximum levels two hours earlier than melatonin. These results demonstrate for the first time that epinephrine can increase the synthesis of melatonin by increasing the transcription of AANAT.

A series of cerous phosphate (CP) catalysts with different crystal structures were synthesized by a hydrothermal method at different temperatures (120, 140, 160, 180 and 200 °C) and their performances for the dehydration of glucose into 5-(hydroxymethyl)furfural (HMF) were also thoroughly investigated. These catalysts were characterized by XRD, N2 adsorption–desorption, SEM, in situ DRIFT, NH3-TPD and XPS. The results indicate that changing the temperature of synthesis will lead to a transformation of the crystal phase and morphology from 120 °C (nanoparticles, hexagonal structure) to 200 °C (nanorods, monoclinic structure); also, the different crystal phases possess different surface Ce4+ amounts and acidities. A good linear correlation is found between the Lewis acid content and the surface Ce4+ amount among these CP catalysts, and very good linearity is also displayed between the Lewis acid amount and the conversion of glucose or the selectivity of HMF, which indicates that Lewis acidity plays an important role in the dehydration of glucose to HMF. CP120, which has a hexagonal crystal structure, exhibits the best catalytic activity (97% conversion of glucose and 61% yield of HMF) because it has the highest amounts of Lewis acid and total acid.

A series of CeaTiOx catalysts with different Ce/Ti molar ratios was prepared by a sol–gel method and used for selective catalytic reaction (SCR) of NO with NH3. The NO conversion values confirmed that the Ce0.3TiOx catalyst showed a much higher activity at low temperature, and the catalyst exhibited 100% NO conversion in the broad temperature range of 200–350 °C and nearly 100% N2 selectivity. The catalysts were characterized by the BET surface area, XRD, XPS, NH3-TPD and H2-TPR. These results demonstrated that the excellent catalytic performance of the complete amorphous Ce0.3TiOx catalyst was associated with the strong interactions between Ce and Ti, the higher BET surface area, abundant acid sites, and greater presence of Ce3+ and chemisorbed oxygen. In situ DRIFTS was used for studies of the reaction mechanism and SO2 resistance. The results indicate that the L–H reaction pathway can be hindered in the presence of SO2 at low temperature ( 200 °C) led to a satisfactory SO2 resistance.

To evaluate the role of CHADSWe searched for cohort studies that reported risk estimates for incidence of ischaemic stroke/TIA or mortality by levels of CHADSEight cohort studies (7 prospective and 1 retrospective) enrolling 31,509 patients with CAD were included. The pooled RR of mortality was 2.38 (95% CI 1.63-3.47) for CHADSCHADS

In this work, the activity of xCuO-Ce0.9Zr0.1O2 catalysts for the reaction of NO + CO was investigated. Especially, in situ DRIFTS was applied to investigate the surface species under the adsorption of NO and/or CO and the reaction of NO and CO to understand the key intermediates species and reaction process of NO + CO. The results suggest that the copper oxide species are well dispersed on the surface of the catalysts, which can be easily reduced to form Cu+ species. The Cu+ species are proposed to be important activity species. The results of this work also suggest that N2O22− is likely an intermediate species that plays an important role in NO reduction by CO. Thus, more Cu+ and highly dispersed copper oxide species are expected to be beneficial for the reaction of CO + NO over the xCuO-Ce0.9Zr0.1O2 catalysts.

Mitochondria are the powerhouses of eukaryotic cells and the main source of reactive oxygen species (ROS) in hypoxic cells, participating in regulating redox homeostasis. The mechanism of tumor hypoxia tolerance, especially the role of mitochondria in tumor hypoxia resistance remains largely unknown. This study aimed to explore the role of mitochondria in tumor hypoxia resistance. We observed that glycolysis in hypoxic cancer cells was up-regulated more rapidly, with far lesser attenuation in aerobic oxidation, thus contributing to a more stable ATP/ADP ratio. In hypoxia, cancer cells rapidly convert hypoxia-induced O2·− into H2O2. H2O2 is further decomposed by a relatively stronger antioxidant system, causing ROS levels to increase lesser compared to normal cells. The moderate ROS leads to an appropriate degree of autophagy, eliminating the damaged mitochondria and offering nutrients to promote mitochondria fusion, thus protects mitochondria and improves hypoxia tolerance in cancer. The functional mitochondria could enable tumor cells to flexibly switch between glycolysis and oxidative phosphorylation to meet the different physiological requirements during the hypoxia/re-oxygenation cycling of tumor growth.

Telomerase activity controls telomere length, and this plays an important role in stem cells, aging and tumors. Antioxidant was shown to protect telomerase activity in normal cells but inhibit that in cancer cells, but the underlying mechanism is elusive. Here we found that 7721 hepatoma cells held a higher redox homeostasis threshold than L02 normal liver cells which caused 7721 cells to have a higher demand for ROS; MnSOD over-expression in 7721 decreased endogenous reactive oxygen species (ROS) and inhibited telomerase activity; Akt phosphorylation inhibitor and NAC both inhibited 7721 telomerase activity. The over-elimination of ROS by NAC resulted in the inhibition of Akt pathway. Our results suggest that ROS is involved in the regulation of cancer telomerase activity through Akt pathway. The different intracellular redox homeostasis and antioxidant system in normal cells and tumor cells may be the cause of the opposite effect on telomerase activity in response to NAC treatment. Our results provide a theoretical base of using antioxidants selectively inhibit cancer telomerase activity. Findings of the present study may provide insights into novel approaches for cancer treatment., Graphical abstract fx1, Highlights • This study explains why antioxidants selectively inhibit cancer telomerase activity. • Cancer cells have higher redox homeostasis threshold than normal cells. • ROS is involved in the regulation of cancer telomerase activity through Akt pathway.

The web reviews contain a lot of features of the evaluation object and express the viewpoints or attitudes of the reviewers. Therefore, analyzing them and identifying the sentiment polarity will be significantly important and valuable. This paper uses the appearing-frequency of noun words to extract the aspect words and uses some semantic rules to extract opinion words to form the aspect -- opinion word pairs. We use the sentiment orientation-point mutual information (SO-PMI) algorithm to calculate the sentiment strength of opinion words and get the semantic orientation of the opinion words and improved the algorithm. With the Chinese reviews of doctors from the medical websites www.39.net and www.chan120.net, experimental results demonstrate the validity of the proposed method.

The transformation of former industrial areas is important to urban redevelopment, although such activity is often limited by possible on-site pollution, complicated ownership, and legal constraints. Rather than treating these areas as a problem, many cities recognize the advantages of redeveloping them because of their often central locations. Some are transformed through a temporary city event with the participation and support of external organizations and planned as a part of the urban development. This paper is an in-depth case study on the planning perspectives of Expo 2010, Shanghai, China, a regeneration project on a former industrial site. By scrutinizing the case with the details based on compiling information, contextualizing the project, and comparing the expectation and reality during the preevent, event phase, and postevent phase of the project, it is found that (1) governmental participation plays a key role in the transformation of former industrial area with city event, especially...