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Your search keyword '"Peng Zhong-xing"' showing total 14 results
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14 results on '"Peng Zhong-xing"'

1. A patient with hereditary transthyretin amyloidosis involving multiple cranial nerves due to a rare p.(Phe84Ser) variant

Author

Yan Xian-rang, Hong Ming-fan, Zhou Zhi-hua, Liu Ai-qun, Peng Zhong-xing, Wu Wei-feng, Jing Cheng, Lin Jia-xiu, Long Ying, and Yu Qing-yun

Subjects
amyloid polyneuropathy, familial amyloidosis peripheral disease, transthyretin, neuroelectrophysiology, p.(phe64ser), p.(phe84ser), Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

We report a 30-year-old man involving gastrointestinal symptoms, vitreous opacity, and multiple cranial neuropathies. Transthyretin-related hereditary amyloidosis genetic testing revealed a rare c.251T > C variant p.(Phe84Ser). Only four cases with this variant have been reported before.

Published
2022
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14. Super-high-dose methylprednisolone does not improve efficacy or induce glucocorticoid resistance in experimental allergic encephalomyelitis.

Author

Wei ZS, Hong MF, Su QX, Wang XH, Yu QY, Peng ZX, Zhang MX, Jie A, Wang R, and Huang YQ

Subjects
Animals, Cytokines biosynthesis, Dose-Response Relationship, Drug, Dose-Response Relationship, Immunologic, Encephalomyelitis, Autoimmune, Experimental pathology, Female, Guinea Pigs, Male, Methylprednisolone therapeutic use, Nuclear Proteins biosynthesis, Protein Isoforms biosynthesis, RNA-Binding Proteins biosynthesis, Rats, Rats, Wistar, Receptors, Glucocorticoid biosynthesis, Serine-Arginine Splicing Factors, Treatment Outcome, Drug Resistance immunology, Encephalomyelitis, Autoimmune, Experimental drug therapy, Encephalomyelitis, Autoimmune, Experimental immunology, Methylprednisolone pharmacology
Abstract

Objective: To investigate whether a super-high dose (SHD) of methylprednisolone (MP) improves its efficacy or induces glucocorticoid (GC) resistance, and to explore the potential mechanisms of GC resistance in experimental allergic encephalomyelitis (EAE)., Methods: The therapeutic effects of SHD and low-dose MP were evaluated in EAE by analyzing clinical scores, pathological changes and cytokine production. Immunohistochemistry and RT-PCR were used to investigate the expression of GC receptor (GR) isoforms and splicing factor SRp30c., Results: Both MP doses had similar therapeutic effects. The ratio of GRα to GRβ was positively correlated with clinical score changes. However, there was no difference in the GRα/GRβ ratio between SHD and low-dose MP groups. SRp30c mRNA was correlated with GRβ expression., Conclusion: This study indicates that the GRα/GRβ ratio is associated with GC sensitivity, and SRp30c may play an important role in promoting alternative splicing of GR pre-mRNA to generate GRβ in EAE rats. Compared with low-dose MP, SHD MP does not improve efficacy or induce GC resistance., (Copyright © 2010 S. Karger AG, Basel.)

Published
2011
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