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The energy accuracy of laser beams is an essential property of the inertial confinement fusion (ICF) facility. However, the energy gain is difficult to control precisely by traditional Frantz-Nodvik equations due to the dramatically-increasing complexity of the huge optical system. A novel method based on ensemble deep neural networks is proposed to predict the laser output energy of the main amplifier. The artificial neural network counts in 39 more related factors that the physical model neglected, and an ensemble method is exploited to obtain robust and stable predictions. The sensitivity of each factor is analyzed by saliency after training to find out the factors which should be controlled strictly. The identification of factor sensitivities reduces relatively unimportant factors, simplifying the neural network model with little effect on the prediction results. The predictive accuracy is benchmarked against the measured energy and the proposed method obtains a relative deviation of 1.59% in prediction, which has a 2.5 times improvement in accuracy over the conventional method.

In the present study, we sought to investigate the influence of high fat diet on the core clock genes and the muscle functional genes daily expression in the skeletal muscle of Chinese soft-shelled turtle. The turtles were fed by two diets including a control fat diet (the CON treatment, 7.98% lipid) and a high fat diet (the HFD treatment, 13.86% lipid) for six weeks and administrated by the photophase regimen of 24h light/dark (12L:12D) cycle. After the feeding trial experiment, we measured the daily expression levels of 17 core clock genes (Clock, Bmal1/2, NPAS2, Tim, Cry1/2, Per1/2, DBP, AANAT, NIFL3, BHLHE40, NR1D2, RORA, RORB, RORC) and 12 muscle functional genes (FBXO32, MBNL1, MSTN, Myf5, Myf6, MyoD, MyoG, MyoM1, PPARa, PDK4, Trim63, UCP3) in the skeletal muscle of the two treatments. The results showed that except for Bmal1, NPAS2, Per2 and RORB, the expression of the other 13 core clock genes exhibited circadian oscillation in the CON treatment. Among the 12 muscle functional genes, MBNL1, PDK4 and MyoM1 did not exhibit circadian oscillation in the CON treatment. In the HFD treatment, the circadian rhythms expressional patterns of the 8 core clock genes (Clock, Bmal2, Cry2, Per1, DBP, NFIL3, BHLHE40 and RORA) and 6 muscle functional genes (MSTN, Myf5, MyoD, MyoG, PPARa and Trim63) were disrupted. In addition, compared with the CON treatment, the circadian expression of the 5 core clock genes (Tim, Cry1, AANAT, NR1D2, RORC) and the 3 muscle functional genes (FBXO32, Myf6, UCP3) showed the advanced or delayed expression peaks in the HFD treatment. In CON treatment, the circadian expression of the MyoG, MyoD, Myf6, FBXO32 and PPARa showed positive or negative correlation with the transcription pattern of Clock, Bmal2, Cry1/2, Per1/2. However, only the FBXO32 and Myf6 presented positive or negative correlation with the circadian expression of Cry1, RORB, AANAT and Tim in HFD treatment. In summary, these results demonstrate that the disruption of the circadian rhythm of the core clock genes and muscle functional genes in the skeletal muscle is closely associated with feeding high fat diet to Chinese soft-shelled turtle.

A new relay-imaged off-axial eight-pass laser amplifier with several joules energy and 1 Hz repetition rate was demonstrated. The extraction efficiency and pulse-to-pulse energy stability were greatly improved. Under the single-pass small-signal gain of 3.6, a net gain of 900 and an effective extraction efficiency of 42.4% in the beam aperture were realized. Pulse-to-pulse energy stability of 0.83% (peak–valley) and 0.17% (root-mean-square) was achieved by the significant saturation of eight-pass amplification, which, to the best of our knowledge, is the best energy stability in several-joules-class amplifiers. The far-field quality was 2.52 times the diffraction limit, and the near-field modulation of the 90% beam aperture was 1.28. No parasitic oscillations or pencil beams were observed. Moreover, another key feature of the proposed amplifier was the ability to remarkably improve the pulse contrast with a unique design.

A high precision inspection method based on image mosaic was proposed for the final optics inspection in an Inertial Confinement Fusion(ICF).The image mosaic method contains image registration stage and image fusion stage.In the image registration stage,a registration method based on feature matching of local damaged area was used to overcome the exposure difference between the subimages and the lack of image information,and the moving information in the inspection system was used in image matching to improve the inspection precision and inspection efficiency.In the image fusion stage,the Poisson image fusion was adopted to eliminate the "stitching line" caused by an exposure difference and to implement the seamless mosaic.The images of final optics inspected by Final Optics Online Inspection(FOOI)was compared with the proposed method and Scale Invariant FeatureTransform(SIFT)method,and the results show that the proposed method is superior to SIFT method.The 4×4mosaic image shows that the inspection resolution of the FOOI device in the ICF has been improved significantly by proposed method.

In grading-eliminated no-nonsense observation of ultrafast incident laser light e-fields(GRENOUILLE) measurements of femtosecond laser pulse, a nonuniform spatial beam profile can largely distort the trace, which results in an inaccurate temporal measurement. The spatial beam profile effects on the GRENOUILLE trace are demonstrated both theoretically and numerically. Results from the numerical simulation show that due to the presence of feedback regarding the validity of the measurement data, the GRENOUILLE phase-retrieval algorithm is insensitive to trace distortion; hence a nonuniform spatial beam profile can hardly introduce any noticeable inaccuracy. Special attention should be paid to the situation where incident beam is too narrow to generate adequate delay between two replicas of the pulse, which leads to a clipped trace followed by a misleading temporal result.