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Objective To investigate the effect of back percussion along the meridian on lung function in patients with pulmonary dysfunction in recovery period of stroke. Methods Totally 90 patients with pulmonary dysfunction in recovery period of stroke were randomly divided into the observation group and control group, with 45 cases in each group. All patients received comprehensive rehabilitation therapy combined with routine care, and those in the observation group were given back percussion therapy along the meridian. The indexes of pulmonary function including partial pressure of oxygen (PaO2), partial pressure of carbon dioxide in artery (PaCO2) and oxyhemoglobin saturation (SaO2) were observed before and after treatment. The 6-minute walking distance, scores of Modified British Medical Research Council (mMRC), Short Form 36 Health Survey Questionnaire (SF-36) and satisfaction degree of two groups were compared. Results Patients in the observation group achieved better outcomes of PaO2、PaCO2、SaO2 compared with those in the control group (P＜0. 01). Patients in the observation group had a longer 6-minute walking distance and lower score of mMRC compared with those in the control group after intervention(P

With a long industrial chain and a powerful ability to drive other industries, the automobile manufacturing industry has a prominent strategic position in the national economy. In recent years, many countries have put on their agenda the digitalization of the automobile manufacturing industry, leading to an connected, autonomous, shared, and electric (also known as CASE)? development trend in the industry. As one of the six major automobile industry clusters in China, the Chengdu-Chongqing economic circle has achieved initial results in the digital transformation of the automobile manufacturing industry. However, the region is still faced with some constraints, such as insufficient digital infrastructure, relatively slow development of new automobile products, insufficient innovation ability of the automobile industry, and complex digital transformation of small and medium-sized automobile enterprises (automobile SMEs). This paper intends to construct a framework for the mechanism of action of the digital transformation in the automobile manufacturing industry, analyze the effects of the digital transformation of the automobile manufacturing industry in the Chengdu-Chongqing economic circle, and propose feasible paths for the digital transformation of the automobile manufacturing industry in the region by drawing on domestic and international experience in this regard. The specific paths include: (a) Smoothing the "dual-core" data chain to facilitate the digital transformation of the automobile manufacturing industry; (b) Developing the new energy vehicle (NEV) industry to upgrade the quality of automobile products; (c) Achieving corner overtaking in the digital transformation of the automobile manufacturing industry with digital technology; (d) Jointly building the automobile industrial park to promote the digital transformation of the industry; (e) Addressing problems facing automobile SMEs in digital transformation via targeted policy tools. [ABSTRACT FROM AUTHOR]

Heracleum dissectum Ledeb. is an ethnic herb used by Oroqen people in Northeast China. The roots of this plant are usually used for treatment of several diseases. However, chemical constituents and pharmacological study were rarely reported. In this present study, phytochemical investigation of H. dissectum methanolic extract (HdME) led to the isolation of a new benzofuran derivative glycoside, 6-methoxycarbonylethyl-benzofuran-5-O-β-d-xylopyranosyl (1 → 2)-β-d-glucopyranoside (1) and a new coumarin glycoside, 6″-β-d-glucopyranosyl-apterin (2). Their structures were elucidated on the basis of physicochemical properties and the detailed interpretation of various spectroscopic data. Adipogenesis accumulating activity was assayed in 3T3-L1 cells. Compound 2 could potently accelerate the accumulation of triglycerides (TG) in 3T3-L1 adipocytes in which TG concentrations were 15.6 ± 2.3, 26.8 ± 1.8, and 35.6 ± 2.6% higher than those of the control group at the concentration of 3, 10, and 30 μM, respectively. In contrast, compound 1 exhibited comparatively weak activity on TG accumulation in adipocytes. This result denoted that the new compound 2 might possess antidiabetic activity in vivo. [ABSTRACT FROM AUTHOR]

Myocardial ischemia is the most common cardiovascular disease. Reperfusion, an important myocardial ischemia tool, causes unexpected and irreversible damage to cardiomyocytes, resulting in myocardial ischemia/reperfusion (MI/R) injury. Upon stress, especially oxidative stress induced by reactive oxygen species (ROS), autophagy, which degrades the intracellular energy storage to produce metabolites that are recycled into metabolic pathways to buffer metabolic stress, is initiated during myocardial ischemia and MI/R injury. Excellent cardioprotective effects of autophagy regulators against MI and MI/R have been reported. Reversing disordered cardiac metabolism induced by ROS also exhibits cardioprotective action in patients with myocardial ischemia. Herein, we review current knowledge on the crosstalk between ROS, cardiac autophagy, and metabolism in myocardial ischemia and MI/R. Finally, we discuss the possible regulators of autophagy and metabolism that can be exploited to harness the therapeutic potential of cardiac metabolism and autophagy in the diagnosis and treatment of myocardial ischemia and MI/R.