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Although diverse uranium (U) adsorbents have been explored, it is still a great challenge for high-efficient uranium extraction form seawater. Herein a wood-mimetic oriented porous Ti3C2Tx-MXene/gelatin hydrogel (MGH) has been explored through growing directional ice crystals cooled by liquid nitrogen and subsequently forming pores by freeze-dry (Ice-template) method, for ultrafast and high-efficient U-adsorption from seawater with great enhancement by both electric field and sunlight. Different from disperse Ti3C2Tx-MXene powder, this MGH not only can be easily utilized but also can own ultrahigh specific surface area for high-efficient U-adsorption. The U-adsorbing capacity of this MGH (10 mg) can reach 4.17 mg·g−1 after only 1 week in 100 kg of seawater, which is outstanding in existing adsorbents. Furthermore, on the positive pole of 0.4 V direct current source or under 1-sun irradiation, the U-adsorbing capacity of the MGH can increase by 57.11% and 13.57%, respectively. Most importantly, the U-adsorption of this hydrogel can be greatly enhanced by simultaneously using the above two methods, which can increase the U-adsorbing capacity by 79.95% reaching 7.51 mg·g−1. This work provides a new biomimetic porous MXene-based hydrogel for electric field/sunlight bi-enhanced high-efficient U-extraction from seawater, which will inspire new strategy to design novel U-adsorbents and systems.

Although metal–organic frameworks (MOFs) own excellent uranium adsorption capacity but are still difficult to conveniently extract uranium from seawater due to the discrete powder state. In this study, a new MOF-based macroporous membrane has been explored, which can high-efficiently extract uranium through continuously filtering seawater. Through modifying the UiO-66 with poly(amidoxime) (PAO), it can disperse well in a N,N-dimethylformamide solution of graphene oxide and cotton fibers. Then, the as-prepared super-hydrophilic MOF-based macroporous membrane can be fabricated after simple suction filtration. Compared with nonmodified MOFs, this UiO-66@PAO can be dispersed uniformly in the membrane because it can stabilize well in the solution, which have largely enhanced uranium adsorbing capacity owing to the modified PAO. Last but not least, different from powder MOFs, this UiO-66@PAO membrane provides the convenient and continuously uranium adsorbing process. As a consequence, the uranium extraction capacity of this membrane can reach 579 mg·g−1 in 32 ppm U-added simulated seawater for only 24 h. Most importantly, this UiO-66@PAO membrane (100 mg) can remove 80.6% uranyl ions from 5 L seawater after 50 filtering cycles. This study provides a universal method to design and fabricate a new MOF-based adsorbent for high-efficient uranium recovery from seawater.

Dynamic covalent bond-based shape memory polymers (DCB-SMPs) are one of most important SMPs which have a wide potential application prospect. Different from common strong covalent bonds, DCBs own relatively weak bonding energy, similarly to the supramolecular interactions of noncovalent bonds, and can dynamically combine and dissociate these bonds. DCB-SMP solids, which can be designed to respond for different stimuli, can provide excellent self-healing, good reprocessability, and high mechanical performance, because DCBs can obtain dynamic cross-linking without sacrificing ultrahigh fixing rates. Furthermore, besides DCB-SMP solids, DCB-SMP hydrogels with responsiveness to various stimuli also have been developed recently, which have special biocompatible soft/wet states. Particularly, DCB-SMPs can be combined with emerging 3D-printing techniques to design various original shapes and subsequently complex shape recovery. This review has summarized recent research studies about SMPs based on various DCBs including DCB-SMP solids, DCB-SMP hydrogels, and the introduction of new 3D-printing techniques using them. Last but not least, the advantages/disadvantages of different DCB-SMPs have been analyzed via polymeric structures and the future development trends in this field have been predicted.

The extent to which organic matters (OM) in PM 2.5 affect virus infections and the key organic molecules involved in this process remain unclear. Herein, this study utilized ultra-high resolution mass spectrometry coupled with in vitro experiments to identify the organic molecules associated with respiratory virus infection for the first time. Water-soluble organic matters (WSOM) and water-insoluble organic matters (WIOM) were separated from PM 2.5 samples collected at the urban area of Guangzhou, China. Their molecular compositions were analyzed using Fourier transform ion cyclotron resonance mass spectrometry. Subsequently, in vitro experiments were conducted to explore the impact of WSOM and WIOM exposure on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pseudo-virus infection in A549 cells. Results revealed that WSOM and WIOM respectively promoted 1.7 to 2.1-fold and 1.9 to 3.5-fold upregulation of SARS-CoV-2 pseudo-virus infection in a concentration-dependent manner (at 25 to 100 μg mL -1 ) compared to the virus-only control group. Partial least squares model analysis indicated that the increased virus infection was likely related to phthalate ester and nitro-aromatic molecules in WSOM, as well as Lipid C molecules with aliphatic and olefinic structures in WIOM. Interestingly, the molecules responsible for upregulating SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) expression and virus infection differed. Thus, it was concluded that ACE2 upregulation alone may not fully elucidate the mechanisms underlying increased susceptibility to virus infection. The findings highlight the critical importance of aromatic and lipid molecules found in OM in relation to respiratory virus infection., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)

Background: Inpatient falls are common adverse events in hospitals, particularly among older adults. However, current research on falls in the older population is limited by small sample sizes and reliance on single-center designs without distinguishing the different levels of fall injuries., Objective: To examine the circumstances of falls in older inpatients and investigate the factors influencing serious fall injuries., Design: A secondary analysis of multicenter cross-sectional administrative data from the China National Database of Nursing Quality (CNDNQ)., Setting(s): 67 hospitals in Hunan, China., Participants: 5143 fall incidents from 5048 older inpatients were included from January 2019 to December 2022., Methods: Descriptive statistics (means, standard deviations, frequencies, and percentages) were used to describe fall characteristics. Given the multilevel data structure, a Generalized Linear Mixed Model (GLMM) with a Logistic link function was employed, treating hospitals and wards as random effects. Univariate and multivariate analyses were conducted., Results: The prevalences of fall-related injuries and serious fall injuries in this study were 63.3 % and 25.0 %, respectively. Nurse-to-patient ratio at the time of fall ≤0.05 (aOR = 1.522, 95 % CI: 1.297-1.785), female gender (aOR = 1.304, 95 % CI: 1.137-1.497), a lengthy hospital stay (aOR = 1.009, 95 % CI: 1.001-1.018) were associated with an increased risk of serious fall injuries. Surgical (aOR = 0.655, 95 % CI: 0.482-0.889) and orthopedic wards (aOR = 0.649, 95 % CI: 0.449-0.939) exhibited lower risks of serious fall injuries than internal medicine wards. The period from 8:00 to 15:59 was associated with a higher risk of serious fall injuries compared to the period from 0:00 to 7:59 (aOR = 1.416, 95 % CI: 1.171-1.713). Compared to lying, standing (aOR = 2.594, 95 % CI: 1.733-3.883), getting in/out of bed (aOR = 1.403, 95 % CI: 1.009-1.951), walking or rehabilitating (aOR = 3.039, 95 % CI: 2.194-4.208), toileting (aOR = 1.411, 95 % CI: 1.038-1.917), and showering (aOR = 2.170, 95 % CI: 1.391-3.385) were associated with an increased risk of serious fall injuries., Conclusions: Fall-related injuries and serious fall injuries are highly prevalent among older inpatients. The study provides insights for targeted fall prevention strategies, improving nursing management and patient safety., Registration: Not registered., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Background: Few studies have integrated the impact of individual and cumulative childhood maltreatment on multiple psychiatric symptoms, with the mechanisms underlying these associations largely unknown. This study aims to comprehensively assess the associations between childhood maltreatment, multiple peripheral immune biomarkers, and various psychiatric symptoms in adulthood and to explore whether peripheral immune inflammation plays a mediator role in the associations between childhood maltreatment and psychiatric symptoms in adulthood., Methods: Using data from the UK Biobank, we constructed a retrospective cohort study of 138,915 participants who provided self-reported childhood maltreatment and had peripheral immune biomarkers assessed. We examined seven types of psychiatric symptoms in adulthood, including depressive symptoms, anxiety symptoms, mania, post-traumatic stress disorder (PTSD), psychotic experiences, self-harm, and alcohol use disorder. Logistic regression models were performed to explore the associations between childhood maltreatment, immune biomarkers, and psychiatric symptoms, calculating the average marginal effects for each indicator of childhood maltreatment. Mediation analyses were conducted to determine the extent to which the immune biomarkers could explain the association between childhood maltreatment and psychiatric symptoms in adulthood. Subgroup and sensitivity analyses were also performed., Results: Among the participants, 77,937 (56.10 %) were female, with a mean age of 55.91 (SD: 7.73) years at baseline. There were dose-response relationships existed between the accumulation of childhood maltreatment indicators and all seven assessed psychiatric symptoms and multimorbidity in adulthood (e.g., for depressive symptoms, OR = 1.67 [95 %CI, 1.57 to 1.78] for one childhood maltreatment indicator; OR = 2.77 [95 % CI, 2.58 to 2.97] for two; OR = 4.91 [95 % CI, 4.61 to 5.24] for three or more). Emotional abuse and physical neglect showed the strongest average marginal effects on psychiatric symptoms. Levels of C-reactive protein (CRP) and counts of leukocytes and neutrophils were positively associated with depressive symptoms (e.g., OR = 1.13 [95 % CI, 1.08 to 1.17] for CRP level), anxiety symptoms, PTSD, and psychotic experiences. Moreover, levels of CRP partially mediated the association between childhood maltreatment scores and psychiatric symptoms, albeit with a relatively low mediation proportion (0.65 %-1.77 %)., Conclusions: Our findings underscore the importance of interventions that address multiple forms of childhood maltreatment to mitigate long-term mental health challenges substantially. While peripheral immunity responses may serve as predictors of mental health problems, they might not to be the primary mechanism through which childhood maltreatment influences psychiatric symptoms in adulthood., (Copyright © 2024 Elsevier Inc. All rights reserved.)

Background: Previous research revealed an association between coffee consumption and depressive symptoms. However, the results differed between studies in adults and adolescents. Additionally, limited research on coffee and depressive symptoms has distinguished between black and sugar-sweetened coffee. Furthermore, few studies have examined the potential sex differences in the abovementioned association. This longitudinal study aimed to explore the associations of black and sugar-sweetened coffee consumption with subsequent depressive symptoms in adolescents while also investigating sex disparities within these associations., Methods: In this longitudinal study, 10,770 individuals completing standardized questionnaires at baseline and follow-up were included in the main analysis. The data were analyzed using generalized linear mixed-effects models, and subgroup analyses were grouped according to sex., Results: After adjusting for covariates and baseline depressive symptoms status, adolescents who consumed black coffee daily (OR, 1.45; 95 % CI, 1.14-1.84) had a greater risk of experiencing depressive symptoms compared with those who did not consume it or consumed it monthly. Similarly, in comparison with none or monthly consumers, those who consumed sugar-sweetened coffee weekly (OR, 1.22; 95 % CI, 1.03-1.44) and daily (OR, 1.32; 95 % CI, 1.02-1.73) demonstrated an elevated risk of having depressive symptoms. Subgroup analyses showed that black and sugar-sweetened coffee consumption was associated with depressive symptoms only in males., Limitations: Self-reported data on coffee consumption and depressive symptoms., Conclusions: Adolescents who consume black or sugar-sweetened coffee weekly or daily are at a higher risk of developing depressive symptoms, with this association appearing to be more pronounced in male adolescents. Future studies are needed to confirm these findings., Competing Interests: Declaration of competing interest The authors declare no conflicts of interest., (Copyright © 2024 Elsevier B.V. All rights reserved.)

Background: Osteoma is the most common benign tumor of the craniomaxillofacial region. Its etiology remains unclear, and the computed tomography and histopathologic examination contribute to its diagnosis. There are very rare reports of recurrence and malignant transformation after surgical resection. Furthermore, giant frontal osteomas that occurred repeatedly and were accompanied by skin multiple keratinous cysts and multinucleated giant cell granulomas have not been reported in previous literature., Methods: The previous cases of recurrent frontal osteoma in the literature and all cases of frontal osteoma in our department in the last 5 years were reviewed., Results: A total of 17 cases of frontal osteoma (mean age 40 y, all female) were reviewed in our department. All patients underwent open surgery to remove the frontal osteoma, and no evidence of complications was found during postoperative follow-up. Two patients underwent 2 or more operations due to the recurrence of osteoma., Conclusions: Two cases of recurrent giant frontal osteoma were reviewed emphatically in this study, including 1 case of giant frontal osteoma with skin multiple keratinous cysts and multinucleated giant cell granulomas. As far as we know, this is the first giant frontal osteoma that occurred repeatedly and was accompanied by skin multiple keratinous cysts and multinucleated giant cell granulomas., Competing Interests: The authors report no conflicts of interest., (Copyright © 2023 by Mutaz B. Habal, MD.)