Search

Your search keyword '"Peng, Yen-Ling"' showing total 32 results
Start Over Author "Peng, Yen-Ling"
32 results on '"Peng, Yen-Ling"'

1. Dysregulated immune and metabolic pathways are associated with poor survival in adult acute myeloid leukemia with CEBPA bZIP in-frame mutations

Author

Tien, Feng-Ming, Yao, Chi-Yuan, Tsai, Xavier Cheng-Hong, Lo, Min-Yen, Chen, Chien-Yuan, Lee, Wan-Hsuan, Lin, Chien-Chin, Kuo, Yuan-Yeh, Peng, Yen-Ling, Tseng, Mei-Hsuan, Wu, Yu-Sin, Liu, Ming-Chih, Lin, Liang-In, Chuang, Ming-Kai, Ko, Bor-Sheng, Yao, Ming, Tang, Jih-Luh, Chou, Wen-Chien, Hou, Hsin-An, and Tien, Hwei-Fang

Published
2024
Full Text
View/download PDF

4. Distinct clinico-biological features in AML patients with low allelic ratio FLT3-ITD: role of allogeneic stem cell transplantation in first remission

Author

Tien, Feng-Ming, Tsai, Cheng-Hong, Huang, Sheng-Chuan, Liu, Jia-Hau, Chen, Chien-Yuan, Kuo, Yuan-Yeh, Chuang, Yi-Kuang, Tseng, Mei-Hsuan, Peng, Yen-Ling, Liu, Ming-Chih, Liu, Chia-Wen, Liao, Xiu-Wen, Lin, Liang-In, Wu, Yu-Sin, Hou, Mei-Fang, Wu, Shang-Ju, Hsu, Szu-Chun, Ko, Bor-Sheng, Chou, Wen-Chien, Yao, Ming, Hou, Hsin-An, Tang, Jih-Luh, and Tien, Hwei-Fang

Published
2022
Full Text
View/download PDF

8. Validation of the prognostic significance of the 2022 European LeukemiaNet risk stratification system in intensive chemotherapy treated aged 18 to 65 years patients with de novo acute myeloid leukemia

Author

Lo, Min‐Yen, primary, Tsai, Xavier Cheng‐Hong, additional, Lin, Chien‐Chin, additional, Tien, Feng‐Ming, additional, Kuo, Yuan‐Yeh, additional, Lee, Wan‐Hsuan, additional, Peng, Yen‐Ling, additional, Liu, Ming‐Chih, additional, Tseng, Mei‐Hsuan, additional, Hsu, Cheng‐An, additional, Chen, Jui‐Che, additional, Lin, Liang‐In, additional, Sun, Hsun‐I, additional, Chuang, Yi‐Kuang, additional, Ko, Bor‐Sheng, additional, Tang, Jih‐Luh, additional, Yao, Ming, additional, Chou, Wen‐Chien, additional, Hou, Hsin‐An, additional, and Tien, Hwei‐Fang, additional

Published
2023
Full Text
View/download PDF

13. Distinct genetic landscapes and their clinical implications in younger and older patients with myelodysplastic syndromes.

Author

Lee, Wan‐Hsuan, Lin, Chien‐Chin, Wang, Yu‐Hung, Yao, Chi‐Yuan, Kuo, Yuan‐Yeh, Tseng, Mei‐Hsuan, Peng, Yen‐Ling, Hsu, Cheng‐An, Sun, Hsun‐I, Chuang, Yi‐Kuang, Hsu, Chia‐Lang, Tien, Feng‐Ming, Tsai, Cheng‐Hong, Chou, Wen‐Chien, Hou, Hsin‐An, and Tien, Hwei‐Fang

Subjects
OLDER patients, MYELODYSPLASTIC syndromes, ASIANS, GENE frequency, GENETIC mutation
Abstract

Myelodysplastic syndromes (MDS) are a group of clinically and genetically diverse diseases that impose patients with an increased risk of leukemic transformation. While MDS is a disease of the elderly, the interplay between aging and molecular profiles is not fully understood, especially in the Asian population. Thus, we compared the genetic landscape between younger and older patients in a cohort of 698 patients with primary MDS to advance our understanding of the distinct pathogenesis and different survival impacts of gene mutations in MDS according to age. We found that the average mutation number was higher in the older patients than younger ones. The younger patients had more WT1 and CBL mutations, but less mutated ASXL1, DNMT3A, TET2, SF3B1, SRSF2, STAG2, and TP53 than the older patients. In multivariable survival analysis, RUNX1 mutations with higher variant allele frequency (VAF) and U2AF1 and TP53 mutations were independent poor prognostic indicators in the younger patients, whereas DNMT3A and IDH2 mutations with higher VAF and TP53 mutations conferred inferior outcomes in the older patients. In conclusion, we demonstrated the distinct genetic landscape between younger and older patients with MDS and suggested that mutations impact survival in an age‐depended manner. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

14. GATA2 zinc finger 1 mutations are associated with distinct clinico-biological features and outcomes different from GATA2 zinc finger 2 mutations in adult acute myeloid leukemia

Author

Tien, Feng-Ming, Hou, Hsin-An, Tsai, Cheng-Hong, Tang, Jih-Luh, Chiu, Yu-Chiao, Chen, Chien-Yuan, Kuo, Yuan-Yeh, Tseng, Mei-Hsuan, Peng, Yen-Ling, Liu, Ming-Chih, Liu, Chia-Wen, Liao, Xiu-Wen, Lin, Liang-In, Lin, Chien-Ting, Wu, Shang-Ju, Ko, Bor-Sheng, Hsu, Szu-Chun, Huang, Shang-Yi, Yao, Ming, Chou, Wen-Chien, and Tien, Hwei-Fang

Published
2018
Full Text
View/download PDF

16. Distinct clinico-biological features in AML patients with low allelic ratio FLT3-ITD: role of allogeneic stem cell transplantation in first remission

Author

Tien, Feng-Ming, primary, Tsai, Cheng-Hong, additional, Huang, Sheng-Chuan, additional, Liu, Jia-Hau, additional, Chen, Chien-Yuan, additional, Kuo, Yuan-Yeh, additional, Chuang, Yi-Kuang, additional, Tseng, Mei-Hsuan, additional, Peng, Yen-Ling, additional, Liu, Ming-Chih, additional, Liu, Chia-Wen, additional, Liao, Xiu-Wen, additional, Lin, Liang-In, additional, Wu, Yu-Sin, additional, Hou, Mei-Fang, additional, Wu, Shang-Ju, additional, Hsu, Szu-Chun, additional, Ko, Bor-Sheng, additional, Chou, Wen-Chien, additional, Yao, Ming, additional, Hou, Hsin-An, additional, Tang, Jih-Luh, additional, and Tien, Hwei-Fang, additional

Published
2021
Full Text
View/download PDF

19. The Clinical Association and Prognostic Impact of IL1RAP Expression in Patients with De Novo Acute Myeloid Leukemia

Author

Wei, Chao-Hung, primary, Tsai, Cheng-Hong, additional, Tang, Jih-Luh, additional, Kuo, Yuan-Yeh, additional, Tien, Feng-Ming, additional, Lin, Chien-Chin, additional, Tseng, Mei-Hsuan, additional, Peng, Yen-Ling, additional, Liu, Ming-Chih, additional, Liu, Chia-Wen, additional, Yao, Ming, additional, Lin, Liang-In, additional, Chou, Wen-Chien, additional, Chen, Chien-Yu, additional, Hou, Hsin-An, additional, and Tien, Hwei-Fang, additional

Published
2019
Full Text
View/download PDF

20. Minimal Residual Disease Monitoring By Next-Generation Sequencing in Patients with Acute Myeloid Leukemia: MRD Positivity after First Consolidation Chemotherapy Can Better Predict Clinical Outcomes Than That after Induction Chemotherapy

Author

Tsai, Cheng-Hong, primary, Tang, Jih-Luh, additional, Tien, Feng-Ming, additional, Kuo, Yuan-Yeh, additional, Lin, Chien-Chin, additional, Tseng, Mei-Hsuan, additional, Peng, Yen-Ling, additional, Liu, Ming-Chih, additional, Liu, Chia-Wen, additional, Yao, Ming, additional, Lin, Liang-In, additional, Chou, Wen-Chien, additional, Chen, Chien-Yu, additional, Hou, Hsin-An, additional, and Tien, Hwei-Fang, additional

Published
2019
Full Text
View/download PDF

21. Incorporation of long non-coding RNA expression profile in the 2017 ELN risk classification can improve prognostic prediction of acute myeloid leukemia patients

Author

Tsai, Cheng-Hong, primary, Yao, Chi-Yuan, additional, Tien, Feng-Min, additional, Tang, Jih-Luh, additional, Kuo, Yuan-Yeh, additional, Chiu, Yu-Chiao, additional, Lin, Chien-Chin, additional, Tseng, Mei-Hsuan, additional, Peng, Yen-Ling, additional, Liu, Ming-Chih, additional, Liu, Chia-Wen, additional, Yao, Ming, additional, Lin, Liang-In, additional, Chou, Wen-Chien, additional, Chen, Chien-Yu, additional, Hou, Hsin-An, additional, and Tien, Hwei-Fang, additional

Published
2019
Full Text
View/download PDF

22. Incorporation of Long Non-Coding RNA Expression Profile in the 2017 ELN Risk Classification Can Improve Prognostic Prediction of Acute Myeloid Leukemia Patients

Author

Tsai, Cheng-Hong, primary, Yao, Chi-Yuan, additional, Tien, Feng-Min, additional, Tang, Jih-Luh, additional, Kuo, Yuan-Yeh, additional, Chiu, Yu-Chiao, additional, Lin, Chien-Chin, additional, Tseng, Mei-Hsuan, additional, Peng, Yen-Ling, additional, Liu, Ming-Chih, additional, Liu, Chia-Wen, additional, Yao, Ming, additional, Lin, Liang-In, additional, Chen, Chien-Yu, additional, Chou, Wen-Chien, additional, Hou, Hsin-An, additional, and Tien, Hwei-Fang, additional

Published
2018
Full Text
View/download PDF

24. Use of SSRI, But Not SNRI, Increased Upper and Lower Gastrointestinal Bleeding

Author

Cheng, Yuan-Lung, Hu, Hsiao-Yun, Lin, Xi-Hsuan, Luo, Jiing-Chyuan, Peng, Yen-Ling, Hou, Ming-Chih, Lin, Han-Chieh, and Lee, Fa-Yauh

Subjects
Adult, Male, Databases, Factual, Incidence, Taiwan, Observational Study, Middle Aged, Risk Factors, Antidepressive Agents, Second-Generation, Humans, Female, Serotonin and Noradrenaline Reuptake Inhibitors, Gastrointestinal Hemorrhage, Selective Serotonin Reuptake Inhibitors, Aged, Follow-Up Studies, Proportional Hazards Models, Retrospective Studies
Abstract

Selective serotonin receptor inhibitor (SSRI) and serotonin-noradrenaline reuptake inhibitor (SNRI) users have been reported to have an increased risk of upper gastrointestinal bleeding (UGIB), but their association with lower gastrointestinal bleeding (LGIB) is less studied. This study aimed to analyze the incidence of UGIB and LGIB among SSRI users, SNRI users, and controls. Using the National Health Insurance Research Database of Taiwan, 9753 subjects who were taking serotonin reuptake inhibitors (8809 with SSRIs, and 944 with SNRIs), and 39,012 age, sex, and enrollment time-matched controls were enrolled at a 1:4 ratio. The log-rank test was used to analyze differences in the cumulative hazard of UGIB and LGIB between groups. Cox proportional hazard regression analysis was used to evaluate the independent risk factors for UGIB and LGIB. During the 10-year follow-up period from 2000 to 2010, SSRI users, but not SNRI users, had significantly higher incidences of UGIB and LGIB than the controls (P

Published
2015

32. Risk Factors for Upper Gastrointestinal Bleeding in Patients Taking Selective COX-2 Inhibitors: A Nationwide Population-Based Cohort Study.

Author

Lin XH, Young SH, Luo JC, Peng YL, Chen PH, Lin CC, Chen WM, Hou MC, and Lee FY

Subjects
Adult, Aged, Cohort Studies, Female, Gastrointestinal Hemorrhage epidemiology, Humans, Incidence, Male, Middle Aged, Proportional Hazards Models, Retrospective Studies, Risk Factors, Cyclooxygenase 2 Inhibitors adverse effects, Gastrointestinal Hemorrhage chemically induced
Abstract

Objective: Cyclooxygenase-2 inhibitors (coxibs) are associated with less upper gastrointestinal bleeding (UGIB) than traditional nonsteroidal anti-inflammatory drugs (tNSAIDs). However, they also increase the risk of UGIB in high-risk patients. We aimed to identify the risk factors of UGIB in coxibs users., Design: Retrospective cohort study., Setting: 2000-2010 National Health Insurance Research Database of Taiwan., Subjects: Patients taking coxibs as the study group and patients not taking any coxibs as controls., Methods: After age, gender, and comorbidity matching by propensity score, 12,145 coxibs users and 12,145 matched controls were extracted for analysis. The primary end point was the occurrence of UGIB. Cox multivariate proportional hazard regression models were used to determine the risk factors for UGIB among all the enrollees and coxibs users., Results: During a mean follow-up of three years, coxibs users had significantly higher incidence of UGIB than matched controls (P < 0.001, log-rank test). Cox regression analysis showed that coxibs increased risk of UGIB in all participants (hazard ratio = 1.37, 95% confidence interval = 1.19-1.55, P < 0.001). Independent risk factors for UGIB among coxibs users were age, male gender, diabetes, chronic renal disease, cirrhosis, history of peptic ulcer disease, PU bleeding (PUB), Helicobacter pylori (H. pylori) infection, and concomitant use of tNSAIDs, acetylsalicylic acid, or thienopyridines., Conclusions: Among coxibs users, H. pylori infection and history of PUB were especially important risk factors for UGIB. Further studies are needed to determine whether proton pump inhibitors might play a protective role in these at-risk patients., (© 2017 American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com)

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results