Search

Your search keyword '"Peng, Xiao-Dan"' showing total 17 results
Start Over Author "Peng, Xiao-Dan"
17 results on '"Peng, Xiao-Dan"'

7. Supplementary Data from Regorafenib Promotes Antitumor Immunity via Inhibiting PD-L1 and IDO1 Expression in Melanoma

Author

Wu, Rui-Yan, primary, Kong, Peng-Fei, primary, Xia, Liang-Ping, primary, Huang, Yun, primary, Li, Zhi-Ling, primary, Tang, Yun-Yun, primary, Chen, Yu-Hong, primary, Li, Xuan, primary, Senthilkumar, Ravichandran, primary, Zhang, Hai-Liang, primary, Sun, Ting, primary, Xu, Xue-Lian, primary, Yu, Yan, primary, Mai, Jia, primary, Peng, Xiao-Dan, primary, Yang, Dong, primary, Zhou, Li-Huan, primary, Feng, Gong-Kan, primary, Deng, Rong, primary, and Zhu, Xiao-Feng, primary

Published
2023
Full Text
View/download PDF

8. Additional file 2 of Disruption of super-enhancer-driven tumor suppressor gene RCAN1.4 expression promotes the malignancy of breast carcinoma

Author

Deng, Rong, Huang, Jun-Hao, Wang, Yan, Li-Huan Zhou, Wang, Zi-Feng, Hu, Bing-Xin, Chen, Yu-Hong, Yang, Dong, Mai, Jia, Li, Zhi-Ling, Zhang, Hai-Liang, Huang, Yun, Peng, Xiao-Dan, Gong-Kan Feng, Zhu, Xiao-Feng, and Tang, Jun

Abstract

Additional file 2 Table S1. The 10 downregulated HSA21 genes in the 112 pairs breast Cancer cohort from TCGA database. Table S2. The 11 upregulated HSA21 genes in the 112 pairs breast cancer cohort from TCGA database. Table S3. Correlation between RCAN1.4 expression and the clinicopathologic characteristics in BC patients. Table S4. Effect of factors on overall survival in BC patients in the univariate and multivariate cox regression model. Table S5. Primers used in RT-qPCR. Table S6. Oligonucleotide sequence of siRNAs. Table S7. Antibodies used in immunoblot.

Published
2020
Full Text
View/download PDF

10. Additional file 3 of Disruption of super-enhancer-driven tumor suppressor gene RCAN1.4 expression promotes the malignancy of breast carcinoma

Author

Deng, Rong, Huang, Jun-Hao, Wang, Yan, Li-Huan Zhou, Wang, Zi-Feng, Hu, Bing-Xin, Chen, Yu-Hong, Yang, Dong, Mai, Jia, Li, Zhi-Ling, Zhang, Hai-Liang, Huang, Yun, Peng, Xiao-Dan, Gong-Kan Feng, Zhu, Xiao-Feng, and Tang, Jun

Abstract

Additional file 3 Figure S1. RCAN1.4 is associated with unfavorable prognosis in BC patients. Figure S2. The tumor suppressive effects of RCAN1.4 in BC cells. Figure S3. The tumor suppressive effects of RCAN1.4 in BC cells via blocking CaN -mediated NFATc1 nuclear localization. Figure S4. ChIP-seq and RNA-seq on the promoter/super-enhancer Region of RCAN1.4 RCAN1.1, and RCAN1.2. Figure S5. Deletion of the human composite RCAN1.4 super-enhancer region promotes the migration and invasion ability of BC cells. Figure S6. The effect of BET inhibition and depletion on the expression of RCAN1.1 and RCAN1.2. Figure S7. RUNX3 activates the transcription of RCAN1.4 by binding to its specific SE. Figure S8. RUNX3 is associated with unfavorable prognosis in BC patients. Figure S9. Full unedited Western blotting gels for all figures.

Published
2020
Full Text
View/download PDF

11. MAPK1/3 kinase-dependent ULK1 degradation attenuates mitophagy and promotes breast cancer bone metastasis

Author

Deng, Rong, primary, Zhang, Hai-Liang, additional, Huang, Jun-Hao, additional, Cai, Rui-Zhao, additional, Wang, Yan, additional, Chen, Yu-Hong, additional, Hu, Bing-Xin, additional, Ye, Zhi-Peng, additional, Li, Zhi-Ling, additional, Mai, Jia, additional, Huang, Yun, additional, Li, Xuan, additional, Peng, Xiao-Dan, additional, Feng, Gong-Kan, additional, Li, Jun-Dong, additional, Tang, Jun, additional, and Zhu, Xiao-Feng, additional

Published
2020
Full Text
View/download PDF

12. Disruption of super-enhancer-driven tumor suppressor gene RCAN1.4 expression promotes the malignancy of breast carcinoma

Author

Deng, Rong, primary, Huang, Jun-Hao, additional, Wang, Yan, additional, Zhou, Li-Huan, additional, Wang, Zi-Feng, additional, Hu, Bing-Xin, additional, Chen, Yu-Hong, additional, Yang, Dong, additional, Mai, Jia, additional, Li, Zhi-Ling, additional, Zhang, Hai-Liang, additional, Huang, Yun, additional, Peng, Xiao-Dan, additional, Feng, Gong-Kan, additional, Zhu, Xiao-Feng, additional, and Tang, Jun, additional

Published
2020
Full Text
View/download PDF

13. MAPK1/3 kinase-dependent ULK1 degradation attenuates mitophagy and promotes breast cancer bone metastasis.

Author

Deng, Rong, Zhang, Hai-Liang, Huang, Jun-Hao, Cai, Rui-Zhao, Wang, Yan, Chen, Yu-Hong, Hu, Bing-Xin, Ye, Zhi-Peng, Li, Zhi-Ling, Mai, Jia, Huang, Yun, Li, Xuan, Peng, Xiao-Dan, Feng, Gong-Kan, Li, Jun-Dong, Tang, Jun, and Zhu, Xiao-Feng

Subjects
METASTATIC breast cancer, BREAST cancer, MITOGEN-activated protein kinases, BONE metastasis, NLRP3 protein
Abstract

The function of mitophagy in cancer is controversial. ULK1 is critical for induction of macroautophagy/autophagy and has a more specific role in mitophagy in response to hypoxia. Here, we show that ULK1 deficiency induces an invasive phenotype of breast cancer cells under hypoxia and increases osteolytic bone metastasis. Mechanistically, ULK1 depletion attenuates mitophagy ability during hypoxia. As a result, the accumulation of damaged, ROS-generating mitochondria leads to activation of the NLRP3 inflammasome, which induces abnormal soluble cytokines secretion, then promotes the differentiation and maturation of osteoclasts, and ultimately results in bone metastasis. Notably, phosphorylation of ULK1 by MAPK1/ERK2-MAPK3/ERK1 kinase triggers its interaction with BTRC and subsequent K48-linked ubiquitination and proteasome degradation. Also, a clearly negative correlation between the expression levels of ULK1 and p-MAPK1/3 was observed in human breast cancer tissues. The MAP2K/MEK inhibitor trametinib is sufficient to restore mitophagy function via upregulation of ULK1, leading to inhibition of NLRP3 inflammasome activation, thereby reduces bone metastasis. These results indicate that ULK1 knockout-mediated mitophagy defect promotes breast cancer bone metastasis and provide evidence to explore MAP2K/MEK- MAPK1/3 pathway inhibitors for therapy, especially in cancers displaying low levels of ULK1. Abbreviations: ATG: autophagy-related; Baf A1: bafilomycin A1; BTRC/β-TrCP: beta-transducin repeat containing E3 ubiquitin protein ligase; CHX: cycloheximide; CM: conditioned media; FBXW7/FBW7: F-box and WD repeat domain containing 7; MAPK1: mitogen-activated protein kinase 1; MTDR: MitoTracker Deep Red; mtROS: mitochondrial reactive oxygen species; microCT: micro-computed tomography; mtROS: mitochondrial reactive oxygen species; OCR: oxygen consumption rate; SQSTM1: sequestosome 1; ACP5/TRAP: acid phosphatase, tartrate resistant; ULK1: unc-51 like autophagy activating kinase 1 [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

14. Regorafenib Promotes Antitumor Immunity via Inhibiting PD-L1 and IDO1 Expression in Melanoma

Author

Wu, Rui-Yan, primary, Kong, Peng-Fei, additional, Xia, Liang-Ping, additional, Huang, Yun, additional, Li, Zhi-Ling, additional, Tang, Yun-Yun, additional, Chen, Yu-Hong, additional, Li, Xuan, additional, Senthilkumar, Ravichandran, additional, Zhang, Hai-Liang, additional, Sun, Ting, additional, Xu, Xue-Lian, additional, Yu, Yan, additional, Mai, Jia, additional, Peng, Xiao-Dan, additional, Yang, Dong, additional, Zhou, Li-Huan, additional, Feng, Gong-Kan, additional, Deng, Rong, additional, and Zhu, Xiao-Feng, additional

Published
2019
Full Text
View/download PDF

15. Polo-Like Kinase 1 phosphorylates and stabilizes KLF4 to promote tumorigenesis in nasopharyngeal carcinoma

Author

Mai, Jia, primary, Zhong, Zhuo-Yan, additional, Guo, Gui-Fang, additional, Chen, Xiu-Xing, additional, Xiang, Yan-Qun, additional, Li, Xuan, additional, Zhang, Hai-Liang, additional, Chen, Yu-Hong, additional, Xu, Xue-Lian, additional, Wu, Rui-Yan, additional, Yu, Yan, additional, Li, Zhi-Ling, additional, Peng, Xiao-Dan, additional, Huang, Yun, additional, Zhou, Li-Huan, additional, Feng, Gong-Kan, additional, Guo, Xiang, additional, Deng, Rong, additional, and Zhu, Xiao-Feng, additional

Published
2019
Full Text
View/download PDF

16. CaMKII-mediated Beclin 1 phosphorylation regulates autophagy that promotes degradation of Id and neuroblastoma cell differentiation

Author

Li, Xuan, primary, Wu, Xiao-Qi, additional, Deng, Rong, additional, Li, Dan-Dan, additional, Tang, Jun, additional, Chen, Wen-Dan, additional, Chen, Jing-Hong, additional, Ji, Jiao, additional, Jiao, Lin, additional, Jiang, Shan, additional, Yang, Fen, additional, Feng, Gong-Kan, additional, Senthilkumar, Ravichandran, additional, Yue, Fei, additional, Zhang, Hai-Liang, additional, Wu, Rui-Yan, additional, Yu, Yan, additional, Xu, Xue-Lian, additional, Mai, Jia, additional, Li, Zhi-Ling, additional, Peng, Xiao-Dan, additional, Huang, Yun, additional, Huang, Xiang, additional, Ma, Ning-Fang, additional, Tao, Qian, additional, Zeng, Yi-Xin, additional, and Zhu, Xiao-Feng, additional

Published
2017
Full Text
View/download PDF

17. Overexpression of PTK6 predicts poor prognosis in bladder cancer patients

Author

Xu, Xue-lian, primary, Ye, Yun-Lin, additional, Wu, Zhi-Ming, additional, He, Qiu-Ming, additional, Tan, Lei, additional, Xiao, Kang-Hua, additional, Wu, Rui-yan, additional, Yu, Yan, additional, Mai, Jia, additional, Li, Zhi-ling, additional, Peng, Xiao-dan, additional, Huang, Yun, additional, Li, Xuan, additional, Zhang, Hai-liang, additional, Zhu, Xiao-feng, additional, and Qin, Zi-Ke, additional

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results