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Your search keyword '"Peng, Guangyin"' showing total 4 results
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4 results on '"Peng, Guangyin"'

1. Large-scale Gastric Cancer Screening and Localization Using Multi-task Deep Neural Network

Author

Yu, Hong, Zhang, Xiaofan, Song, Lingjun, Jiang, Liren, Huang, Xiaodi, Chen, Wen, Zhang, Chenbin, Li, Jiahui, Yang, Jiji, Hu, Zhiqiang, Duan, Qi, Chen, Wanyuan, He, Xianglei, Fan, Jinshuang, Jiang, Weihai, Zhang, Li, Qiu, Chengmin, Gu, Minmin, Sun, Weiwei, Zhang, Yangqiong, Peng, Guangyin, Shen, Weiwei, and Fu, Guohui

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition
Abstract

Gastric cancer is one of the most common cancers, which ranks third among the leading causes of cancer death. Biopsy of gastric mucosa is a standard procedure in gastric cancer screening test. However, manual pathological inspection is labor-intensive and time-consuming. Besides, it is challenging for an automated algorithm to locate the small lesion regions in the gigapixel whole-slide image and make the decision correctly.To tackle these issues, we collected large-scale whole-slide image dataset with detailed lesion region annotation and designed a whole-slide image analyzing framework consisting of 3 networks which could not only determine the screening result but also present the suspicious areas to the pathologist for reference. Experiments demonstrated that our proposed framework achieves sensitivity of 97.05% and specificity of 92.72% in screening task and Dice coefficient of 0.8331 in segmentation task. Furthermore, we tested our best model in real-world scenario on 10,315 whole-slide images collected from 4 medical centers., Comment: under minor revision

Published
2019

3. DNA-protein crosslinks induced by formaldehyde and its repair process

Author

Zhao, Wei, Peng, Guangyin, and Yang, Xu

Subjects
Formaldehyde -- Analysis, DNA probes -- Evaluation, Environmental services industry
Abstract

Byline: Wei Zhao, Guangyin Peng, Xu Yang KCL-SDS assay was used to explore DNA-Protein Crosslinks (DPC) effect induced by formaldehyde (FA) and the repair. Gaseous FA could cause DPC at concentrations as 1.0 mg m−3 and 3.0 mg m−3 (p < 0.01), which was removed within 12 h. Meanwhile, in vitro studies showed that 75 [micro]mol L−1 liquid FA could significantly induce DPC in HepG2 cells, and was removed after 18 h and 24 h. These results suggested that FA could induce DPC at relatively high concentrations, and removing of DPC in vivo required shorter time than that in vitro.

Published
2009

4. [A comparison between the effects on DNA-protein cross-links of Saccharomyces and E. coli induced by formaldehyde].

Author

Gan Y, Xu Q, Peng G, Wu K, and Liu KY

Subjects
Dose-Response Relationship, Drug, Escherichia coli genetics, Pichia genetics, DNA chemistry, DNA Damage, Escherichia coli drug effects, Formaldehyde toxicity, Pichia drug effects, Proteins chemistry
Abstract

To explore the effect of formaldehyde on DNA-protein cross-links (DPC) in eucaryotic cells and prokaryotic cells, Pichia pastoris and E. coli DH5alpha were chosen as materials to evaluate the amount of DPC induced by liquid formaldehyde in vivo by the method of KCl-SDS assay. The results showed that formaldehyde could not induce DPC at low dose(25micromol/L,P > 0.05), but could obviously induce DPC at higher dose (125 and 625micromol/L, P < 0.05). The DPC coefficient in Pichia pastoris was 10-fold higher than that in E. coli DH5alpha. It is concluded that formaldehyde could induce DPC in eucaryotic cells and prokaryotic cells with a dose-dependent manner and the DPC coefficient in Pichia pastoris is higher than that in E. coli DH5alpha.

Published
2007

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