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2. YAP Accelerates Notch-Driven Cholangiocarcinogenesis via mTORC1 in Mice

Author

Lu, Xinjun, Peng, Baogang, Chen, Ge, Pes, Mario G, Ribback, Silvia, Ament, Cindy, Xu, Hongwei, Pal, Rajesh, Rodrigues, Pedro M, Banales, Jesus M, Evert, Matthias, Calvisi, Diego F, Chen, Xin, Fan, Biao, and Wang, Jingxiao

Subjects
Biomedical and Clinical Sciences, Liver Cancer, Liver Disease, Cancer, Rare Diseases, Digestive Diseases, 2.1 Biological and endogenous factors, Aetiology, Adaptor Proteins, Signal Transducing, Adult, Aged, Animals, Bile Duct Neoplasms, Cholangiocarcinoma, Female, Humans, Male, Mechanistic Target of Rapamycin Complex 1, Mice, Middle Aged, Proto-Oncogene Mas, Receptor, Notch1, Transcription Factors, YAP-Signaling Proteins, Medical and Health Sciences, Pathology, Biomedical and clinical sciences, Health sciences
Abstract

Intrahepatic cholangiocarcinoma (iCCA) is a lethal malignant neoplasm with limited therapeutic options. Previous studies have found that Notch1 overexpression alone suffices to induce iCCA in the mouse, albeit after long latency. The current study found that activation of the Yes-associated protein (Yap) proto-oncogene occurs during Notch1-driven iCCA progression. After co-expressing activated Notch1 intracellular domain (Nicd) and Yap (YapS127A) in the mouse liver, rapid iCCA formation and progression occurred in Nicd/Yap mice. Mechanistically, an increased expression of amino acid transporters and activation of the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway was detected in Nicd/Yap mouse liver tumors. Significantly, the genetic deletion of Raptor, the major mTORC1 component, completely suppressed iCCA development in Nicd/Yap mice. Elevated expression of Notch1, YAP, amino acid transporters, and members of the mTORC1 pathway was also detected ubiquitously in a collection of human iCCA specimens. Their levels were associated with a poor patient outcome. This study demonstrates that Notch and YAP concomitant activation is frequent in human cholangiocarcinogenesis. Notch and YAP synergize to promote iCCA formation by activating the mTORC1 pathway.

Published
2021

11. Supplementary Figure from Combination Neoantigen-Based Dendritic Cell Vaccination and Adoptive T-Cell Transfer Induces Antitumor Responses Against Recurrence of Hepatocellular Carcinoma

Author

Peng, Sui, primary, Chen, Shuling, primary, Hu, Wei, primary, Mei, Jie, primary, Zeng, Xuezhen, primary, Su, Tianhong, primary, Wang, Wei, primary, Chen, Zebin, primary, Xiao, Han, primary, Zhou, Qian, primary, Li, Bin, primary, Xie, Yubin, primary, Hu, Huanjing, primary, He, Minghui, primary, Han, Yanyan, primary, Tang, Longqing, primary, Ma, Yifan, primary, Li, Xiaoshuang, primary, Zhou, Xiangjun, primary, Dai, Zihao, primary, Liu, Zelong, primary, Tan, Jiehui, primary, Xu, Lixia, primary, Li, Shaoqiang, primary, Shen, Shunli, primary, Li, Dongming, primary, Lai, Jiaming, primary, Peng, Baogang, primary, Peng, Zhenwei, primary, and Kuang, Ming, primary

Published
2023
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12. Data from Combination Neoantigen-Based Dendritic Cell Vaccination and Adoptive T-Cell Transfer Induces Antitumor Responses Against Recurrence of Hepatocellular Carcinoma

Author

Peng, Sui, primary, Chen, Shuling, primary, Hu, Wei, primary, Mei, Jie, primary, Zeng, Xuezhen, primary, Su, Tianhong, primary, Wang, Wei, primary, Chen, Zebin, primary, Xiao, Han, primary, Zhou, Qian, primary, Li, Bin, primary, Xie, Yubin, primary, Hu, Huanjing, primary, He, Minghui, primary, Han, Yanyan, primary, Tang, Longqing, primary, Ma, Yifan, primary, Li, Xiaoshuang, primary, Zhou, Xiangjun, primary, Dai, Zihao, primary, Liu, Zelong, primary, Tan, Jiehui, primary, Xu, Lixia, primary, Li, Shaoqiang, primary, Shen, Shunli, primary, Li, Dongming, primary, Lai, Jiaming, primary, Peng, Baogang, primary, Peng, Zhenwei, primary, and Kuang, Ming, primary

Published
2023
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15. Vitamin B6 Metabolic Pathway is Involved in the Pathogenesis of Liver Diseases via Multi-Omics Analysis

Author

Mei,Meihua, Liu,Danping, Tang,Xiuxin, You,Ying, Peng,Baogang, He,Xiaoshun, and Huang,Junqi

Subjects
Journal of Hepatocellular Carcinoma
Abstract

Meihua Mei,1– 4,* Danping Liu,1– 4,* Xiuxin Tang,1– 4,* Ying You,1– 4 Baogang Peng,5 Xiaoshun He,1– 3 Junqi Huang1– 4 1Organ Transplant Center, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People’s Republic of China; 2Guangdong Provincial Key Laboratory of Organ Donation & Transplant Immunology, Guangzhou, 510080, People’s Republic of China; 3Guangdong Provincial International Cooperation Base of Science & Technology (Organ Transplantation), Guangzhou, 510080, People’s Republic of China; 4Department of Laboratory Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People’s Republic of China; 5Hepatobiliary Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People’s Republic of China*These authors contributed equally to this workCorrespondence: Junqi Huang, The First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhong Shan Er Lu, Guangzhou, 510080, People’s Republic of China, Tel +86 (20) 28823388 ext. 8670, Email huangjq@mail.sysu.edu.cnPurpose: To clarify the underlying regulatory mechanisms of progression from liver cirrhosis to hepatocellular carcinoma (HCC), we analyzed the microbiomics, metabolomics, and proteomics in plasma and tissues from patients with HCC or decompensated liver cirrhosis (DC).Patients and Methods: Tissues and plasma from 44 HCC patients and 28 patients with DC were collected for metabolomic analysis. 16S rRNA sequencing was performed in nine HCC tissues (HCCT), four distal noncancerous tissues (HCCN), and 11 DC tissues (DCT). Five HCC tissues had liver cirrhosis (HCCT-LC). Five hepatocellular carcinoma tissues without liver cirrhosis (HCCT-NLC) and five DCT were selected for proteomic sequencing. After combining proteomic and metabolomic analysis, we constructed a mouse model of chronic liver injury using carbon tetrachloride (CCl4) and treated them with vitamin B6 (VB6).Results: 16s rRNA sequence results showed that HCC tissues had higher alpha diversity. The highest LDA scores were detected for Elizabethkingia in HCCT, Subsaxibacter in DCT, and Stenotrophomon in HCCN. Metabolomics results demonstrated some metabolites, including capric acid, L-threonate, choline, alpha-D-Glucose, D-ribose, betaine, 2E-eicosenoic acid, linoleic acid, L-palmitoylcarnitine, taurodeoxycholic acid, L-pyroglutamic acid, androsterone sulfate, and phthalic acid mono-2-ethylhexyl ester (MEHP), had better diagnostic efficacy than AFP (AUC: 0.852; 95% CI: 0.749, 0.954). In a combined analysis of metabolomics and proteomics, we found that HCCT-LC had more obvious disorders of VB6 metabolism and pentose and glucuronate interconversions than DCT, and kynurenine metabolism disorder was more significant in HCCT-LC than in HCCT-NLC. In the CCl4-induced chronic liver injury model, after VB6 supplementation, inflammatory cell infiltration, hepatocyte edema, and degeneration were significantly improved.Conclusion: We found significant differences in the flora distribution between HCCT and DC; MEHP was a new diagnostic biomarker of HCC, and VB6 ameliorated the inflammatory cell infiltration, hepatocyte edema, and degeneration in chronic liver injury.Keywords: hepatocellular carcinoma, cirrhosis, proteomics, metabolomics, microbiomics, vitamin B6

Published
2022

17. Supplementary Data from Multiomic Analysis Reveals Comprehensive Tumor Heterogeneity and Distinct Immune Subtypes in Multifocal Intrahepatic Cholangiocarcinoma

Author

Chen, Shuling, primary, Xie, Yubin, primary, Cai, Yuhong, primary, Hu, Huanjing, primary, He, Minghui, primary, Liu, Lijuan, primary, Liao, Changyi, primary, Wang, Yuanqi, primary, Wang, Jianping, primary, Ren, Xiaoxue, primary, Zeng, Qianwen, primary, Peng, Hong, primary, Shen, Shunli, primary, Li, Shaoqiang, primary, Li, Dongming, primary, Lai, Jiaming, primary, Peng, Baogang, primary, Ren, Jian, primary, Kuang, Ming, primary, and Peng, Sui, primary

Published
2023
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18. Table S9 from The Influence of Immune Heterogeneity on the Effectiveness of Immune Checkpoint Inhibitors in Multifocal Hepatocellular Carcinomas

Author

Huang, Manling, primary, He, Minghui, primary, Guo, Yu, primary, Li, Heping, primary, Shen, Shunli, primary, Xie, Yubin, primary, Li, Xiaoxing, primary, Xiao, Han, primary, Fang, Lujing, primary, Li, Dongming, primary, Peng, Baogang, primary, Liang, Lijian, primary, Yu, Jun, primary, Kuang, Ming, primary, Xu, Lixia, primary, and Peng, Sui, primary

Published
2023
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19. Figure S1-S17 from The Influence of Immune Heterogeneity on the Effectiveness of Immune Checkpoint Inhibitors in Multifocal Hepatocellular Carcinomas

Author

Huang, Manling, primary, He, Minghui, primary, Guo, Yu, primary, Li, Heping, primary, Shen, Shunli, primary, Xie, Yubin, primary, Li, Xiaoxing, primary, Xiao, Han, primary, Fang, Lujing, primary, Li, Dongming, primary, Peng, Baogang, primary, Liang, Lijian, primary, Yu, Jun, primary, Kuang, Ming, primary, Xu, Lixia, primary, and Peng, Sui, primary

Published
2023
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21. Lenvatinib Combined With Transarterial Chemoembolization as First-Line Treatment for Advanced Hepatocellular Carcinoma: A Phase III, Randomized Clinical Trial (LAUNCH)

Author

Peng, Zhenwei, primary, Fan, Wenzhe, additional, Zhu, Bowen, additional, Wang, Guoying, additional, Sun, Junhui, additional, Xiao, Chengjiang, additional, Huang, Fuxi, additional, Tang, Rong, additional, Cheng, Yu, additional, Huang, Zhen, additional, Liang, Yuchuang, additional, Fan, Huishuang, additional, Qiao, Liangliang, additional, Li, Fuliang, additional, Zhuang, Wenquan, additional, Peng, Baogang, additional, Wang, Jiping, additional, Li, Jiaping, additional, and Kuang, Ming, additional

Published
2023
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24. A modified method for isolating mouse islets of an adequate quality, quantity, and purity

Author

Xu, Jiejie, Peng, Baogang, Zhang, Caiyun, Xu, Jiwei, Ma, Yi, and Lu, Xinjun

Subjects
Zoological specimens -- Collections and collecting -- Physiological aspects -- Methods, Islands of Langerhans -- Physiological aspects -- Methods, Diabetes -- Research, Biological sciences
Abstract

Abstract: Mouse islets are widely used in diabetes research. Thus an adequate quality, quantity, and purity of islets are needed for high-quality investigations. We performed a combination of filtration and [...]

Published
2017

25. Combination Neoantigen-Based Dendritic Cell Vaccination and Adoptive T-Cell Transfer Induces Antitumor Responses Against Recurrence of Hepatocellular Carcinoma

Author

Peng, Sui, primary, Chen, Shuling, additional, Hu, Wei, additional, Mei, Jie, additional, Zeng, Xuezhen, additional, Su, Tianhong, additional, Wang, Wei, additional, Chen, Zebin, additional, Xiao, Han, additional, Zhou, Qian, additional, Li, Bin, additional, Xie, Yubin, additional, Hu, Huanjing, additional, He, Minghui, additional, Han, Yanyan, additional, Tang, Longqing, additional, Ma, Yifan, additional, Li, Xiaoshuang, additional, Zhou, Xiangjun, additional, Dai, Zihao, additional, Liu, Zelong, additional, Tan, Jiehui, additional, Xu, Lixia, additional, Li, Shaoqiang, additional, Shen, Shunli, additional, Li, Dongming, additional, Lai, Jiaming, additional, Peng, Baogang, additional, Peng, Zhenwei, additional, and Kuang, Ming, additional

Published
2022
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27. Toripalimab plus bevacizumab as first-line treatment for advanced hepatocellular carcinoma: A single-arm phase II study.

Author

Hao, Chunyi, primary, Du, Chengyou, additional, Peng, Baogang, additional, Zhang, Wu, additional, Shan, Yunfeng, additional, Lv, Ang, additional, Wu, Jianhui, additional, Shang, Changzhen, additional, Luo, Xuan, additional, Wei, Jinxing, additional, Xiao, Heng, additional, Qiu, Jianguo, additional, Hua, Yunpeng, additional, Shen, Shunli, additional, Wang, Ting, additional, Dai, Shengjie, additional, Chen, Xiang, additional, Yan, Shican, additional, and Hao, Chunyi, additional

Published
2022
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28. Somatic Mutation Profiles Revealed by Next Generation Sequencing (NGS) in 39 Chinese Hepatocellular Carcinoma Patients

Author

Ke, Lixin, primary, Shen, Jianming, additional, Feng, Jikun, additional, Chen, Jialin, additional, Shen, Shunli, additional, Li, Shaoqiang, additional, Kuang, Ming, additional, Liang, Lijian, additional, Lu, Cuncun, additional, Li, Dongming, additional, He, Qiang, additional, Peng, Baogang, additional, and Hua, Yunpeng, additional

Published
2022
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29. Senescence Reprograming Drived by Polybromo-1 Deficiency Promotes Intrahepatic Cholangiocarcinoma Progression

Author

Wu, Xiwen, primary, Zhang, Yi, additional, Song, Zimin, additional, Li, Muqi, additional, Qian, Baifeng, additional, Lin, Shuirong, additional, Zhao, Chenfeng, additional, Lin, Haozhong, additional, Wen, Haoxiang, additional, Huang, Yihao, additional, wang, Nian, additional, Huang, Ya, additional, Peng, Hong, additional, Guo, Yu, additional, Guo, Ruomi, additional, Peng, Baogang, additional, and Shen, Shunli, additional

Published
2022
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30. Genomic Characteristics, Metabolic Signature and Immune Microenvironment of Clonorchis Sinensis-Related Intrahepatic Cholangiocarcinoma

Author

Xu, Lixia, primary, Zhang, Ying, additional, Lin, Zhilong, additional, Deng, Xinlang, additional, Huang, Mingle, additional, Ren, Xiaoxue, additional, Yang, Qingxia, additional, Zheng, Gaomin, additional, Chen, Zebin, additional, Wu, Zhongdao, additional, Sun, Xi, additional, Lin, Jie, additional, Li, Xiaoxing, additional, Shen, Shunli, additional, Li, Shaoqiang, additional, Peng, Baogang, additional, Liang, Lijian, additional, Lai, Jiaming, additional, Xie, Yubin, additional, and Kuang, Ming, additional

Published
2022
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32. METTL1 promotes hepatocarcinogenesis via m 7 G tRNA modification‐dependent translation control

Author

Chen, Zhihang, primary, Zhu, Wanjie, additional, Zhu, Shenghua, additional, Sun, Kaiyu, additional, Liao, Junbin, additional, Liu, Haining, additional, Dai, Zihao, additional, Han, Hui, additional, Ren, Xuxin, additional, Yang, Qingxia, additional, Zheng, Siyi, additional, Peng, Baogang, additional, Peng, Sui, additional, Kuang, Ming, additional, and Lin, Shuibin, additional

Published
2021
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34. Multiomic Analysis Reveals Comprehensive Tumor Heterogeneity and Distinct Immune Subtypes in Multifocal Intrahepatic Cholangiocarcinoma

Author

Chen, Shuling, primary, Xie, Yubin, additional, Cai, Yuhong, additional, Hu, Huanjing, additional, He, Minghui, additional, Liu, Lijuan, additional, Liao, Changyi, additional, Wang, Yuanqi, additional, Wang, Jianping, additional, Ren, Xiaoxue, additional, Zeng, Qianwen, additional, Peng, Hong, additional, Shen, Shunli, additional, Li, Shaoqiang, additional, Li, Dongming, additional, Lai, Jiaming, additional, Peng, Baogang, additional, Ren, Jian, additional, Kuang, Ming, additional, and Peng, Sui, additional

Published
2021
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35. N7-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression

Author

Dai, Zihao, primary, Liu, Haining, additional, Liao, Junbin, additional, Huang, Cheng, additional, Ren, Xiaoxue, additional, Zhu, Wanjie, additional, Zhu, Shenghua, additional, Peng, Baogang, additional, Li, Shaoqiang, additional, Lai, Jiaming, additional, Liang, Lijian, additional, Xu, Lixia, additional, Peng, Sui, additional, Lin, Shuibin, additional, and Kuang, Ming, additional

Published
2021
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38. Pristimerin synergistically sensitizes conditionally reprogrammed patient derived-primary hepatocellular carcinoma cells to sorafenib through endoplasmic reticulum stress and ROS generation by modulating Akt/FoxO1/p27kip1 signaling pathway

Author

Tang, Yubo, primary, Chen, Jie, additional, Li, Jiaqi, additional, Zheng, Yifan, additional, Zhong, Xiuxiu, additional, Huang, Shuai, additional, Chen, Bin, additional, Peng, Baogang, additional, Zou, Xuenong, additional, and Chen, Xiao, additional

Published
2021
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39. Three‐day postoperative antibiotics reduces post‐hepatectomy infection rate in hepatitis B virus‐related hepatocellular carcinoma

Author

Chen, Zebin, primary, Jiang, Hong, additional, Wang, Yuanqi, additional, Liang, Ruiming, additional, Xu, Lixia, additional, Lai, Jiaming, additional, Shen, Jingxian, additional, Li, Jiali, additional, Li, Dongming, additional, Li, Shaoqiang, additional, Lei, Kai, additional, Zhou, Qian, additional, Peng, Baogang, additional, Peng, Hong, additional, Peng, Sui, additional, and Kuang, Ming, additional

Published
2021
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48. The Influence of Immune Heterogeneity on the Effectiveness of Immune Checkpoint Inhibitors in Multifocal Hepatocellular Carcinomas

Author

Huang, Manling, primary, He, Minghui, additional, Guo, Yu, additional, Li, Heping, additional, Shen, Shunli, additional, Xie, Yubin, additional, Li, Xiaoxing, additional, Xiao, Han, additional, Fang, Lujing, additional, Li, Dongming, additional, Peng, Baogang, additional, Liang, Lijian, additional, Yu, Jun, additional, Kuang, Ming, additional, Xu, Lixia, additional, and Peng, Sui, additional

Published
2020
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