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Your search keyword '"Pen'kov LIu"' showing total 5 results
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5 results on '"Pen'kov LIu"'

1. [Antioxidant enzymes in skin experimental burn trauma].

Author

Mokhal'chik EV, Titkova SM, Anurov MV, Pen'kov LIu, and Korkina LG

Subjects
Animals, Burns pathology, Disease Models, Animal, Epidermis pathology, Inflammation enzymology, Inflammation pathology, Lipopolysaccharides pharmacology, Male, Rats, Rats, Wistar, Antioxidants metabolism, Burns enzymology, Epidermis enzymology, Gene Expression Regulation, Enzymologic drug effects, Oxidoreductases metabolism
Abstract

The effect of experimental burn trauma (20%) on myeloperoxidase (MPO) and antioxidant enzymes (catalase, glutathione peroxidase (GPO), glutathione-S-transferase (GST)) was studied in unburned skin, epidermis (20 mm from the burned area) and the wound tissue of rats. The most common features were the increase of MPO on the 1st day and a delayed increase of GPO and GST after the 4th day. The additional operations (necrectomy) and lipopolysaccharide administration induced marked inflammatory reaction in skin and epidermis (evaluated by the increase in MPO and GPO/GST activities).

Published
2006

3. [Changes in reactivity of the contractile system of the small intestine caused by disturbed parasympathetic innervation].

Author

Tsibulevskiĭ AIu, Khripun AI, Ettinger AP, Dubovaia TK, Polivoda MD, and Pen'kov LIu

Subjects
Animals, Electrophysiology, Intestine, Small drug effects, Male, Muscle Contraction drug effects, Muscle Contraction physiology, Muscle, Smooth drug effects, Parasympathetic Nervous System drug effects, Parasympathomimetics pharmacology, Quinuclidines pharmacology, Rats, Vagotomy, Intestine, Small innervation, Intestine, Small physiology, Muscle, Smooth innervation, Muscle, Smooth physiology, Parasympathetic Nervous System physiology
Abstract

We studied the role of parasympathetic division of vegetative nervous system in regulation of the intestine activity in rats subjected to bilateral subdiaphragmal vagotomy, the response of the neuromuscular apparatus of the small intestine to stimulation by aceclydine taken as an example. Intravenous injection of aceclydine (0.5 mg/kg) into intact animals is accompanied by characteristics changes in the electrical and contractile activities of the intestine, which reflect its enhanced motor activity. Vagotomy leads to changes of response of the intestine to pharmacological stimulation, most expressed within 3, 7, and 30 days. It was proposed that distortion of reactive properties of the intestine contractile system under these conditions is related to functional changes in rhythm-setting neurons of intramural ganglia and M-cholinoreceptors of neuromuscular synapses.

Published
1998

4. [The current methods for the prevention, diagnosis and surgical treatment of the adhesive complications of peritonitis in children].

Author

Ivanova MN, Konovalov AK, Pen'kov LIu, and Sergeev AV

Subjects
Animals, Appendectomy, Child, Diagnosis, Differential, Disease Models, Animal, Humans, Peritonitis diagnosis, Peritonitis prevention & control, Peritonitis surgery, Postoperative Care, Postoperative Complications diagnosis, Postoperative Complications etiology, Postoperative Complications surgery, Prodigiozan administration & dosage, Rats, Time Factors, Tissue Adhesions diagnosis, Tissue Adhesions etiology, Tissue Adhesions prevention & control, Tissue Adhesions surgery, Peritonitis complications, Postoperative Complications prevention & control
Abstract

The paper is based on clinical and experimental findings of one of the postoperative complications of purulent peritonitis, namely adhesion formation. The authors consider that impaired cytodynamic relationship in the focus of peritonitis concurrent with gastrointestinal paresis underlie the pathogenesis of the above-mentioned complication. In this connection, the authors propose a set of anti-adhesive measures, which involves prodigiosane cytomodulation and differential treatment of enteroparesis. Intestinal ultrasonic echocardiography was used for diagnostic purposes. Laparoscopy was employed in the surgical treatment of adhesive complications of peritonitis, which allowed relaparotomy to be eliminated or its traumaticity to be reduced to a great extent. There were no deaths and relapses of adhesive disease.

Published
1993

5. [The diagnosis of motor disorders of the small intestine in peritonitis in children and the rationale for pathogenetic methods of correction].

Author

Pen'kov LIu, Ettinger AP, Polivoda MD, Baĭtinger VF, and Konovalov AK

Subjects
Adolescent, Animals, Autonomic Nervous System physiopathology, Child, Child, Preschool, Combined Modality Therapy, Efferent Pathways physiopathology, Female, Humans, Infant, Intestine, Small innervation, Intestine, Small surgery, Male, Peritonitis etiology, Peritonitis physiopathology, Peritonitis surgery, Rats, Rats, Wistar, Gastrointestinal Motility, Intestine, Small physiopathology, Peritonitis diagnosis
Abstract

The work deals with the results of experimental (200 animals) and clinical (20 patients) study into the role of the efferent link of the autonomic nervous system in regulating motor activity of the small intestine and the possibility of using direct electroenteromyography in the diagnosis of the stages of paresis and the degree of motor disorders in peritonitis. The pathogenetic methods of treatment of intestinal paresis are substantiated. Medicamentous stimulation of the cholinergic nervous system in peritonitis is effective only when intactness of the intramural ganglia is maintained, in which case the electroenteromyographic test with neostigmine methylsulfate or cerucal may be conducted. The pathogenetic method of treatment in all other cases is medicamentous blockade of the adrenergic nervous system.

Published
1992

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