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1. Hunting for the nature of the enigmatic narrow-line Seyfert 1 galaxy PKS 2004-447

Author

Berton, M., Peluso, G., Marziani, P., Komossa, S., Foschini, L., Ciroi, S., Chen, S., Congiu, E., Gallo, L. C., Björklund, I., Crepaldi, L., Di Mille, F., Järvelä, E., Kotilainen, J., Kreikenbohm, A., Morrell, N., Romano, P., Sani, E., Terreran, G., Tornikoski, M., Vercellone, S., and Vietri, A.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

Narrow-line Seyfert 1 (NLS1) galaxies are a class of active galactic nuclei (AGN) that, in some cases, can harbor powerful relativistic jets. One of them, PKS 2004-447, shows gamma-ray emission, and underwent its first recorded multifrequency flare in 2019. However, past studies revealed that in radio this source can be classified as a compact steep-spectrum source (CSS), suggesting that, unlike other gamma-ray sources, the relativistic jets of PKS 2004-447 have a large inclination with respect to the line of sight. We present here a set of spectroscopic observations of this object, aimed at carefully measuring its black hole mass and Eddington ratio, determining the properties of its emission lines, and characterizing its long term variability. We find that the black hole mass is $(1.5\pm0.2)\times10^7$ M$_\odot$, and the Eddington ratio is 0.08. Both values are within the typical range of NLS1s. The spectra also suggest that the 2019 flare was caused mainly by the relativistic jet, while the accretion disk played a minor role during the event. In conclusion, we confirm that PKS 2004-447 is one of the rare examples of gamma-ray emitting CSS/NLS1s hybrid, and that these two classes of objects are likely connected in the framework of AGN evolution., Comment: 14 pages, 8 figures, 4 tables, resubmitted to A&A after minor comments from the referee

Published
2021
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3. New onset of guttate psoriasis, Hallopeau’s continuous acrodermatitis, and psoriatic arthritis after COVID-19 vaccine

Author

Zoli, A, Peluso, Giusy, Grimaldi, M, De Simone, Clara, D'Agostino, Maria Antonietta, Ortolan, A, Peluso, G, De Simone, C (ORCID:0000-0002-0898-0045), D’Agostino, MA (ORCID:0000-0002-5347-0060), Zoli, A, Peluso, Giusy, Grimaldi, M, De Simone, Clara, D'Agostino, Maria Antonietta, Ortolan, A, Peluso, G, De Simone, C (ORCID:0000-0002-0898-0045), and D’Agostino, MA (ORCID:0000-0002-5347-0060)

Abstract

Not available

Published
2024

4. Predicting ventricular arrhythmia inducibility in ajmaline-induced brugada type I pattern: validation of the dST-Tiso interval

Author

Iacopino, S, primary, Sorrenti, P, additional, Petretta, A, additional, Colella, J, additional, Di Vilio, A, additional, Statuto, G, additional, Filannino, P, additional, Artale, P, additional, Giacopelli, D, additional, Camastra, D, additional, Peluso, G, additional, Fabiano, G, additional, Campagna, G, additional, Fabiano, E, additional, and Cecchini, F, additional

Published
2023
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5. Pulse-induced switches in a Josephson tunnel stacked device

Author

Pepe, G. P., Peluso, G., Valentino, M., Barone, A., Parlato, L., Esposito, E., Granata, C., Russo, M., De Leo, C., and Rotoli, G.

Subjects
Condensed Matter - Superconductivity
Abstract

Pulse activated transitions from the metastable to the running state and viceversa have been observed in a stacked double tunnel Nb-based Josephson system. Experimental results are compared with numerical simulations based on the Sine-Gordon model of the stacked junctions by injecting pulses with variable amplitude in one of the junctions of the stack, and observing the voltage response of the other junction. Both experimental and numerical results show the possibility to induce both direct and back-switching transitions from the metastable to the running state simply by changing the amplitude of the electronic pulses injected across the stack device., Comment: Submitted to Appl.Phys.Letters, May 2001 PDF format: 14 pages, 3 Figures

Published
2001
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7. POS0026 THE INDEPENDENT INFLUENCE OF SEX ON THE DISEASE IMPACT DOMAINS IN PSORIATIC ARTHRITIS IS MODEST, ONCE CONFOUNDERS ARE TAKEN INTO ACCOUNT

Author

Ortolan, A., primary, Capacci, A., additional, Zoli, A., additional, DI Murro, S., additional, Cristiano, F., additional, Cerasuolo, P., additional, La Ferrara, R., additional, Lanzo, L., additional, Tur, C., additional, Rubortone, P., additional, Verardi, L., additional, Calabrese, G., additional, Aquilino, P., additional, Peluso, G., additional, and D’agostino, M. A., additional

Published
2023
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8. POS1353 SEMIQUANTITATIVE ASSESSMENT OF KNEE OSTEOARTHRITIS-RELATED SYNOVITIS COMPARED TO CHRONIC INFLAMMATORY ARTHRITIDES: RELATION TO AGE AND IMPACT ON BONE/STRUCTURAL DAMAGE

Author

Rubortone, P., primary, Leone, F., additional, Petricca, L., additional, Perniola, S., additional, Bruno, D., additional, Gigante, M. R., additional, Di Mario, C., additional, Tolusso, B., additional, Peluso, G., additional, Gremese, E., additional, D’agostino, M. A., additional, Alivernini, S., additional, and Lizzio, M. M., additional

Published
2023
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9. POS0425 SINGLE-CELL RNA SEQUENCING OF SYNOVIAL TISSUE-DERIVED MYELOID CELLS IN PSORIATIC ARTHRITIS PATIENTS ACROSS DISEASE PHASES

Author

Bruno, D., primary, Somma, D., additional, Tolusso, B., additional, Di Mario, C., additional, Coletto, L. A., additional, Elmesmari, A., additional, Petricca, L., additional, Gigante, M. R., additional, Perniola, S., additional, Paglionico, A., additional, Varriano, V., additional, Peluso, G., additional, D’agostino, M. A., additional, Gremese, E., additional, Kurowska-Stolarska, M., additional, and Alivernini, S., additional

Published
2023
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10. Chronic related group classification system as a new public health tool to predict risk and outcome of COVID-19 in patients with systemic rheumatic diseases: A population-based study of more than forty thousand patients

Author

De Lorenzis, E., Parente, Paolo, Natalello, G., Soldati, S., Bosello, Silvia Laura, Barbara, A., Sorge, C., Axelrod, S., Verardi, Lucrezia, Cerasuolo, Pier Giacomo, Peluso, Giusy, Gemma, A., Davoli, Marina, Biliotti, D., Bruzzese, Vincenzo, Goletti, M., Di Martino, M., D'Agostino, M. A., De Lorenzis E., Parente P., Natalello G., Soldati S., Bosello S. L. (ORCID:0000-0002-4837-447X), Barbara A., Sorge C., Axelrod S., Verardi L., Cerasuolo P. G., Peluso G., Gemma A., Davoli M., Biliotti D., Bruzzese V., Goletti M., Di Martino M., D'Agostino M. A., De Lorenzis, E., Parente, Paolo, Natalello, G., Soldati, S., Bosello, Silvia Laura, Barbara, A., Sorge, C., Axelrod, S., Verardi, Lucrezia, Cerasuolo, Pier Giacomo, Peluso, Giusy, Gemma, A., Davoli, Marina, Biliotti, D., Bruzzese, Vincenzo, Goletti, M., Di Martino, M., D'Agostino, M. A., De Lorenzis E., Parente P., Natalello G., Soldati S., Bosello S. L. (ORCID:0000-0002-4837-447X), Barbara A., Sorge C., Axelrod S., Verardi L., Cerasuolo P. G., Peluso G., Gemma A., Davoli M., Biliotti D., Bruzzese V., Goletti M., Di Martino M., and D'Agostino M. A.

Published
2023

13. Erratum: Correction: Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence (eLife (2020) 9 PII: e80871)

Author

Alessio N., Squillaro T., Di Bernardo G., Galano G., De Rosa R., Melone M. A. B., Peluso G., Galderisi U., Alessio, N., Squillaro, T., Di Bernardo, G., Galano, G., De Rosa, R., Melone, M. A. B., Peluso, G., and Galderisi, U.

Subjects
medicine, stem cells, regenerative medicine, human, mouse
Abstract

Senescent cells secrete several molecules, collectively named senescence-associated secretory phenotype (SASP). In the SASP of cells that became senescent following several in vitro chemical and physical stress, we identified the IGFBP-4 protein that can be considered a general stress mediator. This factor appeared to play a key role in senescence-paracrine signaling. We provided evidences showing that genotoxic injury, such as low dose irradiation, may promote an IGFBP-4 release in bloodstream both in mice irradiated with 100 mGy X-ray and in human subjects that received Computer Tomography. Increased level of circulating IGFBP-4 may be responsible of pro-aging effect. We found a significant increase of senescent cells in the lungs, heart, and kidneys of mice that were intraperitoneally injected with IGFBP-4 twice a week for two months. We then analyzed how genotoxic stressors may promote the release of IGFBP-4 and the molecular pathways associated with the induction of senescence by this protein.

Published
2022

17. POS1251 INCIDENCE AND OUTCOMES OF SARS-CoV-2 INFECTION IN PATIENTS WITH SYSTEMIC AUTOIMMUNE RHEUMATIC DISEASES: A POPULATION-BASED STUDY OF MORE THAN FOUR MILLION INHABITANTS IN THE LAZIO ITALIAN REGION

Author

De Lorenzis, E., primary, Parente, P., additional, Natalello, G., additional, Soldati, S., additional, Bosello, S. L., additional, Barbara, A., additional, Sorge, C., additional, Axelrod, S., additional, Verardi, L., additional, Cerasuolo, P. G., additional, Peluso, G., additional, Gemma, A., additional, Davoli, M., additional, Biliotti, D., additional, Bruzzese, V., additional, Goletti, M., additional, DI Martino, M., additional, and D’agostino, M. A., additional

Published
2022
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18. POS0316 SEMIQUANTITATIVE ASSESSMENT OF SYNOVITIS ON US-GUIDED SYNOVIAL MEMBRANE BIOPSIES IS CONTINGENT ON DISEASE PHASE AND PREDICTIVE OF TREATMENT RESPONSE IN NAIVE TO TREATMENT PSORIATIC ARTHRITIS

Author

Bruno, D., primary, Tolusso, B., additional, Gessi, M., additional, DI Mario, C., additional, Gigante, M. R., additional, Petricca, L., additional, Perniola, S., additional, Paglionico, A., additional, Varriano, V., additional, Peluso, G., additional, Bui, L., additional, Elmesmari, A., additional, Somma, D., additional, D’agostino, M. A., additional, Kurowska-Stolarska, M., additional, Gremese, E., additional, and Alivernini, S., additional

Published
2022
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22. Hunting for the nature of the enigmatic narrow-line Seyfert 1 galaxy PKS 2004-447

Author

Berton, M., primary, Peluso, G., additional, Marziani, P., additional, Komossa, S., additional, Foschini, L., additional, Ciroi, S., additional, Chen, S., additional, Congiu, E., additional, Gallo, L. C., additional, Björklund, I., additional, Crepaldi, L., additional, Di Mille, F., additional, Järvelä, E., additional, Kotilainen, J., additional, Kreikenbohm, A., additional, Morrell, N., additional, Romano, P., additional, Sani, E., additional, Terreran, G., additional, Tornikoski, M., additional, Vercellone, S., additional, and Vietri, A., additional

Published
2021
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25. New onset of remitting seronegative symmetrical synovitis with pitting oedema and palmoplantar psoriasis flare-up after Sars-Cov-2 vaccination

Author

Quattrini, Laura, Verardi, Lucrezia, Caldarola, Giacomo, Peluso, Giusy, De Simone, Clara, D'Agostino, Maria Antonietta, Quattrini L., Verardi L., Caldarola G. (ORCID:0000-0002-8837-9232), Peluso G., De Simone C. (ORCID:0000-0002-0898-0045), D'Agostino M. (ORCID:0000-0002-5347-0060), Quattrini, Laura, Verardi, Lucrezia, Caldarola, Giacomo, Peluso, Giusy, De Simone, Clara, D'Agostino, Maria Antonietta, Quattrini L., Verardi L., Caldarola G. (ORCID:0000-0002-8837-9232), Peluso G., De Simone C. (ORCID:0000-0002-0898-0045), and D'Agostino M. (ORCID:0000-0002-5347-0060)

Published
2021

26. Telemedicine will not keep us apart in COVID-19 pandemic

Author

Perniola, S., Alivernini, Stefano, Varriano, V., Paglionico, A., Tanti, G., Rubortone, Pietro, Lanzo, Lucia, Melpignano, Fabrizio, Tur, Carlo, De Lorenzis, E., Peluso, Giusy, Capacci, A., Gremese, Elisa, Alivernini S. (ORCID:0000-0002-7383-4212), Rubortone P., Lanzo L., Melpignano F., Tur C., Peluso G., Gremese E. (ORCID:0000-0002-2248-1058), Perniola, S., Alivernini, Stefano, Varriano, V., Paglionico, A., Tanti, G., Rubortone, Pietro, Lanzo, Lucia, Melpignano, Fabrizio, Tur, Carlo, De Lorenzis, E., Peluso, Giusy, Capacci, A., Gremese, Elisa, Alivernini S. (ORCID:0000-0002-7383-4212), Rubortone P., Lanzo L., Melpignano F., Tur C., Peluso G., and Gremese E. (ORCID:0000-0002-2248-1058)

Abstract

not applicable

Published
2021

27. High-dose fotemustine in temozolomide-pretreated glioblastoma multiforme patients

Author

Marinelli A., Lamberti G., Cerbone L., Cordua N., Buonerba C., Peluso G., Di Lorenzo G., De Placido S., Marinelli A., Lamberti G., Cerbone L., Cordua N., Buonerba C., Peluso G., Di Lorenzo G., De Placido S., Marinelli, A., Lamberti, G., Cerbone, L., Cordua, N., Buonerba, C., Peluso, G., Di Lorenzo, G., and De Placido, S.

Subjects
Adult, Aged, 80 and over, Male, Incidence, glioblastoma, Administration, Intravenou, Middle Aged, Nitrosourea Compound, fotemustine, Thrombocytopenia, Disease-Free Survival, Drug Administration Schedule, Antineoplastic Agent, Brain Neoplasm, Dacarbazine, Temozolomide, Female, Neoplasm Recurrence, Local, Organophosphorus Compound, MGMT, Aged, Human
Abstract

Background: Glioblastoma multiforme (GBM) is a rare and deadly disease, with a reported average incidence rate of 3.19 cases per 100,000 inhabitants. Fotemustine, a third-generation nitrosourea with an alanine phosphor carrier that facilitates cellular penetration, has been extensively investigated in the setting of recurrent/progressive disease after initial treatment. Fotemustine is usually administered following a schedule consisting of 3 doses every week, followed by maintenance doses administered every 3 weeks. Methods: In this phase I/II trial, we aimed to assess whether the use of a biweekly regimen allowed administration of higher dose than the standard 100mg/m2 dose approved per label indication in a population of patients with recurrent GBM. In this phase I/II trial, fotemustine was administered intravenously over 1hour every 2 weeks at either 120 or 140mg/m2 doses for up to 1 year, until disease progression, unacceptable toxicity, or patient's request to withdraw from the study. The phase I part of the trial was conducted following the classic 3+3 study design. The phase II part of the trial was a single-arm study. The primary efficacy endpoint was the percentage of patients who had not progressed after 24 weeks (PFS-24). Results: Thirty-seven patients were enrolled in this phase I/II trial from August 2006 to November 2011. Treatment was well tolerated in the overall population. Main severe toxicity was grades 3 and 4 thrombocytopenia, which occurred in 4 of 6 patients treated at the 140mg/m2 dose level and in 3 of 31 patients treated at 120mg/m2. Median PFS and overall survival were 12.1 (1-40.2) weeks and 19.7 (1-102) weeks, respectively. Conclusion: We conclude that fotemustine can be safely administered at 120mg/m2 biweekly. The efficacy of such modified schedule and doses should be compared to the biweekly schedule at 80mg 2 and the standard weekly schedule at 80 to 100mg/m2.

Published
2018

29. Ultrafast photoresponse of superconductor/ferromagnet nano-layered hybrids

Author

Pepe, G.P., Pan, D., Pagliarulo, V., Parlato, L., Marrocco, N., De Lisio, C., Peluso, G., Barone, A., di Uccio, U.S., Casaburi, A., Tafuri, F., Khafizov, M., Taneda, T., and Sobolewski, R.

Subjects
Barium compounds -- Electric properties, Barium compounds -- Optical properties, Ferromagnetism -- Analysis, Nickel alloys -- Electric properties, Nickel alloys -- Optical properties, Niobium -- Electric properties, Niobium -- Optical properties, Photodetectors -- Design and construction, Photodetectors -- Evaluation, Superconductors -- Optical properties, Business, Electronics, Electronics and electrical industries
Published
2009

30. Erratum: Eradication of HCV infection with the direct-acting antiviral therapy in renal allograft recipients (BioMed Research International (2019) 2019 (8) DOI: 10.1155/2019/4674560)

Author

Calogero A., Sagnelli E., Creta M., Angeletti S., Peluso G., Incollingo P., Candida M., Minieri G., Carlomagno N., Dodaro C. A., CICCOZZI, ANTONELLO, Sagnelli C., Calogero, A., Sagnelli, E., Creta, M., Angeletti, S., Peluso, G., Incollingo, P., Candida, M., Minieri, G., Carlomagno, N., Dodaro, C. A., Ciccozzi, Antonello, and Sagnelli, C.

Abstract

[This corrects the article DOI: 10.1155/2019/4674560.].

Published
2019

31. Risk-related 18F-FDG PET/CT and new diagnostic strategies in patients with solitary pulmonary nodule: the ITALIAN multicenter trial

Author

Spadafora, M, Pace, L, Evangelista, L, Mansi, L, Del Prete, F, Saladini, G, Miletto, P, Fanti, S, Del Vecchio, S, Guerra, L, Pepe, G, Peluso, G, Nicolai, E, Storto, G, Ferdeghini, M, Giordano, A, Farsad, M, Schillaci, O, Gridelli, C, Cuocolo, A, Spadafora M., Pace L., Evangelista L., Mansi L., Del Prete F., Saladini G., Miletto P., Fanti S., Del Vecchio S., Guerra L., Pepe G., Peluso G., Nicolai E., Storto G., Ferdeghini M., Giordano A., Farsad M., Schillaci O., Gridelli C., Cuocolo A., Spadafora, M, Pace, L, Evangelista, L, Mansi, L, Del Prete, F, Saladini, G, Miletto, P, Fanti, S, Del Vecchio, S, Guerra, L, Pepe, G, Peluso, G, Nicolai, E, Storto, G, Ferdeghini, M, Giordano, A, Farsad, M, Schillaci, O, Gridelli, C, Cuocolo, A, Spadafora M., Pace L., Evangelista L., Mansi L., Del Prete F., Saladini G., Miletto P., Fanti S., Del Vecchio S., Guerra L., Pepe G., Peluso G., Nicolai E., Storto G., Ferdeghini M., Giordano A., Farsad M., Schillaci O., Gridelli C., and Cuocolo A.

Abstract

Purpose: Diagnosis of solitary pulmonary nodule (SPN) is an important public health issue and 18F-FDG PET/CT has proven to be more effective than CT alone. Pre-test risk stratification and clinical presentation of SPN could affect the diagnostic strategy. A relevant issue is whether thoracic segmental (s)-PET/CT could be implemented in patients with SPN. This retrospective multicenter study compared the results of FDG whole-body (wb)-PET/CT to those of s-PET/CT. Methods: 18F-FDG PET/CT of 502 patients, stratified for pre-test cancer risk, were retrospectively analyzed. The thoracic part of wb-PET/CT, considered s-PET/CT, was compared to wb-PET/CT. Clinical and PET/CT variables were investigated for SPN characterization as well as for identification of patients in whom s-PET/CT could be performed. Histopathology or follow-up data were used as a reference. Results: In the study population, 36% had malignant, 35% benign, and 29% indeterminate SPN. 18F-FDG uptake indicative of thoracic and extra-thoracic lesions was detectable in 13% and 3% of the patients. All patients with extra-thoracic metastases (n = 13) had thoracic lymph node involvement and highest 18F-FDG uptake at level of SPN (negative predictive value 100%). Compared to wb-PET/CT, s-PET/CT could save about 2/3 of 18F-FDG dose, radiation exposure or scan-time, without affecting the clinical impact of PET/CT. Conclusion: Pre-test probability of malignancy can guide the diagnostic strategy of 18FDG-PET/CT in patients with SPN. In subjects with low-intermediate pretest probability s-PET/CT imaging might be planned in advance, while in those at high risk and with thoracic lymph node involvement a wb-PET/CT is necessary

Published
2018

32. Performance of FDG-PET/CT in solitary pulmonary nodule based on pre-test likelihood of malignancy: results from the ITALIAN retrospective multicenter trial

Author

Evangelista, L, Cuocolo, A, Pace, L, Mansi, L, Del Vecchio, S, Miletto, P, Sanfilippo, S, Pellegrino, S, Guerra, L, Pepe, G, Peluso, G, Salvatore, M, Galicchio, R, Zuffante, M, Annunziata, S, Farsad, M, Chiaravalloti, A, Spadafora, M, Evangelista L., Cuocolo A., Pace L., Mansi L., Del Vecchio S., Miletto P., Sanfilippo S., Pellegrino S., Guerra L., Pepe G., Peluso G., Salvatore M., Galicchio R., Zuffante M., Annunziata S., Farsad M., Chiaravalloti A., Spadafora M., Evangelista, L, Cuocolo, A, Pace, L, Mansi, L, Del Vecchio, S, Miletto, P, Sanfilippo, S, Pellegrino, S, Guerra, L, Pepe, G, Peluso, G, Salvatore, M, Galicchio, R, Zuffante, M, Annunziata, S, Farsad, M, Chiaravalloti, A, Spadafora, M, Evangelista L., Cuocolo A., Pace L., Mansi L., Del Vecchio S., Miletto P., Sanfilippo S., Pellegrino S., Guerra L., Pepe G., Peluso G., Salvatore M., Galicchio R., Zuffante M., Annunziata S., Farsad M., Chiaravalloti A., and Spadafora M.

Abstract

Purpose: The aim of this study was to determine the performance of 18F-FDG-PET/CT in patients with solitary pulmonary nodule (SPN), stratifying the risk according to the likelihood of pulmonary malignancy. Methods: FDG-PET/CT of 502 patients, stratified for pre-test cancer risk, were retrospectively analyzed. FDG uptake in SPN was assessed by a 4-point scoring system and semiquantitative analysis using the ratio between SUVmax in SPN and SUVmean in mediastinal blood pool (BP) and between SUVmax in SPN and SUVmean in liver (L). Histopathology and/or follow-up data were used as standard of reference. Results: SPN was malignant in 180 (36%) patients, benign in 175 (35%), and indeterminate in 147 (29%). The 355 patients with a definitive SPN nature (malignant or benign) were considered for the analysis. Considering FDG uptake ≥ 2, sensitivity, specificity, positive (PPV) and negative (NPV) predictive values, and accuracy were 85.6%, 85.7%, 86%, 85.2%, and 85.6% respectively. Sensitivity and PPV were higher (P < 0.05) in intermediate and high-risk patients, while specificity and NPV were higher (P < 0.05) in low-risk patients. On receiver operating characteristic curve analysis, the cut-offs for better discrimination between benign and malignant SPN were 1.56 (sensitivity 81% and specificity 87%) and 1.12 (sensitivity 81% and specificity 86%) for SUVmax/SUVmeanBP and SUVmax/SUVmeanL respectively. In intermediate and high-risk patients, including the SUVmax/SUVmeanBP, the specificity shifted from 85% and 50% to 100%. Conclusion: Visual FDG-PET/CT has an acceptable performance in patients with SPN, but accuracy improves when SUVratios are considered, particularly in patients with intermediate and high risk of malignancy.

Published
2018

33. Non destructive evaluation of advanced composite materials for aerospace application using HTS SQUIDs

Author

Bonavolonta, C., Velentino, M., Peluso, G., and Barone, A.

Subjects
Superconducting quantum interference devices -- Design and construction, Composite materials -- Electric properties, Eddy currents (Electric) -- Analysis, Business, Electronics, Electronics and electrical industries
Abstract

A non destructive evaluation (NDE) Eddy current system prototype based on HTS dc SQUID magnetomer designed for testing of carbon fiber composite material which provides information about the localization and the dimension of the defect even if it is not visible to naked eyes is presented.

Published
2007

34. No higher risk of respiratory symptoms in Italian rheumatological patients under IL-6R-inhibitor therapy in SARS-CoV-2 pandemic

Author

Alivernini, Stefano, Petricca, L., Perniola, S., Fedele, A. L., Gigante, M. R., Capacci, A., Paglionico, A., Varriano, V., De Lorenzis, E., Lanzo, Lucia, Melpignano, Fabrizio, Rubortone, Pietro, Tanti, Giacomo, Tur, Carlo, Bruno, Dario, Gigante, Laura, Natalello, Gerlando, Verardi, Lucrezia, Di Mario, Clara, Tolusso, Barbara, Mirone, Luisa, Lizzio, Marco Maria, Zoli, Angelo, Peluso, G., Bosello, Silvia Laura, Gremese, Elisa, Alivernini S. (ORCID:0000-0002-7383-4212), Lanzo L., Melpignano F., Rubortone P., Tanti G., Tur C., Bruno D., Gigante L., Natalello G., Verardi L., Di Mario C., Tolusso B. (ORCID:0000-0002-9108-6609), Mirone L. (ORCID:0000-0001-5820-5533), Lizzio M. M., Zoli A. (ORCID:0000-0003-1597-058X), Bosello S. L. (ORCID:0000-0002-4837-447X), Gremese E. (ORCID:0000-0002-2248-1058), Alivernini, Stefano, Petricca, L., Perniola, S., Fedele, A. L., Gigante, M. R., Capacci, A., Paglionico, A., Varriano, V., De Lorenzis, E., Lanzo, Lucia, Melpignano, Fabrizio, Rubortone, Pietro, Tanti, Giacomo, Tur, Carlo, Bruno, Dario, Gigante, Laura, Natalello, Gerlando, Verardi, Lucrezia, Di Mario, Clara, Tolusso, Barbara, Mirone, Luisa, Lizzio, Marco Maria, Zoli, Angelo, Peluso, G., Bosello, Silvia Laura, Gremese, Elisa, Alivernini S. (ORCID:0000-0002-7383-4212), Lanzo L., Melpignano F., Rubortone P., Tanti G., Tur C., Bruno D., Gigante L., Natalello G., Verardi L., Di Mario C., Tolusso B. (ORCID:0000-0002-9108-6609), Mirone L. (ORCID:0000-0001-5820-5533), Lizzio M. M., Zoli A. (ORCID:0000-0003-1597-058X), Bosello S. L. (ORCID:0000-0002-4837-447X), and Gremese E. (ORCID:0000-0002-2248-1058)

Abstract

NA

Published
2020

35. Subclinical atherosclerosis and endothelial dysfunction in patients with polymyalgia rheumatica: a pilot study

Author

Santoro, L, Birra, D, Bosello, Silvia Laura, Nesci, Domenico Arturo, Di Giorgio, A, Peluso, Eugenio, Giupponi, B, Zaccone, V, Gasbarrini, Antonio, Zoli, Angelo, Santoliquido, Angelo, Bosello, S (ORCID:0000-0002-4837-447X), Nesci, A (ORCID:0000-0001-9466-1755), Peluso, G, Gasbarrini, A (ORCID:0000-0002-7278-4823), Zoli, A (ORCID:0000-0003-1597-058X), Santoliquido, A (ORCID:0000-0003-1539-4017), Santoro, L, Birra, D, Bosello, Silvia Laura, Nesci, Domenico Arturo, Di Giorgio, A, Peluso, Eugenio, Giupponi, B, Zaccone, V, Gasbarrini, Antonio, Zoli, Angelo, Santoliquido, Angelo, Bosello, S (ORCID:0000-0002-4837-447X), Nesci, A (ORCID:0000-0001-9466-1755), Peluso, G, Gasbarrini, A (ORCID:0000-0002-7278-4823), Zoli, A (ORCID:0000-0003-1597-058X), and Santoliquido, A (ORCID:0000-0003-1539-4017)

Abstract

N/A

Published
2020

38. Electromagnetic non-destructive evaluation of fiberglass/aluminum laminates using HTS SQUID magnetometers

Author

Bonavolonta, C., Pepe, G.P., Valentino, M., Peluso, G., Caprino, G., and Lopresto, V.

Subjects
Non-destructive testing -- Research, Glass reinforced plastics -- Research, High temperature superconductors -- Electric properties, Superconducting quantum interference devices -- Design and construction, Business, Electronics, Electronics and electrical industries
Abstract

A nondestructive evaluation of Fiber/Metal Laminates (FML) specimens based on an eddy-current technique that uses an HTS Superconducting QUantum Interference Device (SQUID) magnetometer is proposed .The purpose of this technique is to demonstrate that this technique is capable of detecting the presence of damage hidden by plastic surface deformation due to the high sensitivity of the HTS SQUID magnetic phase derivative.

Published
2005

39. Proximity effect in NiCu-based Josephson tunnel junctions

Author

Latempa, R., Parlato, L., Peluso, G., Pepe, G.P., Golubov, A.A., Ruotolo, A., and Barone, A.

Subjects
Nickel compounds -- Electric properties, Copper compounds -- Electric properties, Tunneling (Physics) -- Analysis, Josephson junction -- Design and construction, Business, Electronics, Electronics and electrical industries
Abstract

The experimental results of both fabrication and the characterization of superconducting tunnel junctions based on Nb/NiCu superconductor/ferromagnet (S/F) bilayers are presented. Results are compared with theoretical predictions from a proximity model for S/F bilayers in the framework of Usadel equations for the S and F layer.

Published
2005

40. Inflammatory bowel disease: Differential expression of multiple transglutaminases in human colon: impaired keratinocyte transglutaminase expression in ulcerative colitis

Author

D'Argenio, G., Calvani, M., Della Valle, N., Cosenza, V., Di Matteo, G., Giorgio, P., Margarucci, S., Petillo, O., Jori, F.P., Galderisi, U., and Peluso, G.

Subjects
Wound healing -- Research, Ulcerative colitis -- Care and treatment, Transglutaminases -- Properties, Rats as laboratory animals -- Models, Keratinocytes -- Genetic aspects, Colon (Anatomy) -- Abnormalities, Health
Published
2005

43. Analysis of low-velocity impact damage in reinforced carbon fiber composites by HTS-SQUID magnetometers

Author

Ruosi, A., Valentino, M., Peluso, G., and Pepe, G.

Subjects
Non-destructive testing -- Research, Superconducting quantum interference devices -- Research, Superconductivity -- Research, Business, Electronics, Electronics and electrical industries
Abstract

Research describing a high temperature superconducting quantum interference device for evaluating low velocity impact damage is presented. The use of the device on multi-ply carbon fibres is analysed.

Published
2001

44. A new superconducting device with transistor-like properties

Author

Pepe, G, Parlato, L, Ammendola, G, Esposito, E, Peluso, G, Barone, A, and Booth, N

Subjects
Superconductivity -- Research, Transistor circuits -- Research, Business, Electronics, Electronics and electrical industries
Abstract

Research is presented describing the study of superconducting electronics properties which resemble transistor elements and support low temperature applications.

Published
2001

45. FRI0270 ONE-YEAR EFFECTIVENESS, RETENTION RATE AND SAFETY OF SECUKINUMAB IN ANKYLOSING SPONDYLITIS AND PSORIATIC ARTHRITIS: A REAL-LIFE MULTICENTRE STUDY

Author

Chimenti, M. S., primary, Fonti, G. L., additional, Conigliaro, P., additional, Sunzini, F., additional, Scrivo, R., additional, Navarini, L., additional, Triggianese, P., additional, Peluso, G., additional, Scolieri, P., additional, Caccavale, R., additional, Picchianti-Diamanti, A., additional, De Martino, E., additional, Salemi, S., additional, Birra, D., additional, Altobelli, A., additional, Paroli, M., additional, Bruzzese, V., additional, Laganà, B., additional, Gremese, E., additional, Conti, F., additional, Afeltra, A., additional, and Perricone, R., additional

Published
2020
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46. AB0757 ASSOCIATION BETWEEN DEPRESSIVE SYMPTOMS AND ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH PSORIATIC ARTHRITIS

Author

De Lorenzis, E., primary, DI Giorgio, A., additional, Natalello, G., additional, Nesci, A., additional, Bruno, D., additional, Lucchetti, D., additional, Tanti, G., additional, DI Mario, C., additional, Rubortone, P., additional, Magurano, M. R., additional, Tolusso, B., additional, Santoliquido, A., additional, Peluso, G., additional, and Gremese, E., additional

Published
2020
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48. ARE MITOCHONDRIA A POSSIBLE THERAPEUTIC TARGET IN HUNTINGTON'S DISEASE?

Author

Melone, M, Di Cristo, F, Digilio, FA, Paladino, S, Valentino, A, Finicelli, M, Squillaro, T, Napolitano, F, Scialo, F, Galderisi, U, Giordano, A, Peluso, G, M. Melone, F. Di Cristo, FA. Digilio, S. Paladino, A. Valentino, M. Finicelli, T Squillaro, F. Napolitano, F. Scialo, U. Galderisi, A. Giordano, G. Peluso, Melone, M, Di Cristo, F, Digilio, Fa, Paladino, S, Valentino, A, Finicelli, M, Squillaro, T, Napolitano, F, Scialo, F, Galderisi, U, Giordano, A, and Peluso, G

Abstract

Background Mitochondrial dysfunction, characterized by abnormalities of mitochondrial biogenesis, dynamics, trafficking, and alterations in the synthesis of high-energy molecules, seems to play a fundamental role in the pathogenesis of neurodegeneration in Huntington’s disease (HD). Meldonium is a small molecule that inhibits endogenous carnitine synthesis and carnitine cell uptake. The decrease of carnitine availability inside the cell induces a significant reprogramming of cell metabolic pathways that apparently counters the mitochondrial dysfunction, at least in the case of heart or brain ischemia. Aims To evaluate neuroprotective actions of meldonium in both in vitro and in vivo HD models. Methods We used STHdhQ111/Q111 cells expressing a mutated form of the huntingtin protein (mHtt), and a transgenic Drosophila model of HD in which the expression of Htt, with a 128Q expansion (Q128HD-FL) in the nervous system, led to progressive motor performance deficits. Results We found that meldonium could prevent cytotoxicity induced by serum deprivation in STHdhQ111/Q111 cells. Meldonium could also reduce the accumulation of mHtt aggregates inside the cell. In addition, meldonium was able to upregulate the expression of PGC-1α, which is a master co-regulator of mitochondrial biogenesis, energy homeostasis, and antioxidant defense, as well as a potential HD target. As expected, the increase of PGC-1α was accompanied by the increment of mitochondrial mass and by the rebalancing of mitochondrial dynamics with a promotion of the mitochondrial fusion. Interestingly, when given per os, meldonium significantly alleviated motor dysfunction and prolonged the survival of transgenic Drosophila model of HD. Conclusions Our study strongly suggests, after considering these factors together, that meldonium (itself or as a lead structure for the synthesis of novel drugs) is a potential treatment for the management of HD.

Published
2018

49. Experimental and numerical results of electromagnetic nondestructive testing with HTc SQUIDs

Author

Ruosi, A., Pepe, G., Peluso, G., Valentino, M., and Monebhurrun, V.

Subjects
Integrated circuits -- Testing, Non-destructive testing -- Methods, Printed circuits -- Testing, Superconducting quantum interference devices -- Usage, Business, Electronics, Electronics and electrical industries
Abstract

The effectiveness of an eddy-current nondestructive evaluation (NDE) system based on high-temperature superconducting quantum interference devices in detecting surface and subsurface artificial features in Al-Ti planar structures has been assessed. Finite element method and volume integrals are used in modeling the anomalous flaws. Results indicate that the NDE system is very accurate based on the close agreement between experimental and computed data.

Published
1999

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