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36 results on '"Pelliccia, Piernicola"'

5. Pediatric cystic diseases of the kidney

Author

Ferro, Federica, Vezzali, Norberto, Comploj, Evi, Pedron, Elena, Di Serafino, Marco, Esposito, Francesco, Pelliccia, Piernicola, Rossi, Eugenio, Zeccolini, Massimo, and Vallone, Gianfranco

Published
2019
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7. Kidney function and renal resistive index in children with juvenile idiopathic arthritis

Author

Cafarotti, Alessandro, Marcovecchio, Maria Loredana, Lapergola, Giuseppe, Di Battista, Caterina, Marsili, Manuela, Basilico, Raffaella, Di Donato, Giulia, David, Daniela, Pelliccia, Piernicola, Chiarelli, Francesco, Breda, Luciana, Marcovecchio, Loredana [0000-0002-4415-316X], and Apollo - University of Cambridge Repository

Subjects
Male, Inflammation, Adolescent, Renal resistive index, Juvenile arthritis, General Medicine, Kidney, General Biochemistry, Genetics and Molecular Biology, Arthritis, Juvenile, Methotrexate, Creatinine, Renal damage, Humans, Female, Cystatin C, Child, Urinary albumin excretion
Abstract

Juvenile idiopathic arthritis (JIA) is a common pediatric rheumatic disease. Renal manifestations have been rarely observed in JIA, although amyloidosis could be a renal complication in systemic JIA (sJIA). To investigate renal damage in JIA children and to establish the relationship with treatment. Blood urea nitrogen (BUN), creatinine, cystatin C (CysC), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), urinary albumin excretion (UAE), estimated glomerular filtration rate (eGFR), and renal resistive index (RRI) were assessed in 49 JIA children (9 boys/40 girls, mean age 10.3 ± 3.8 years) and in 49 healthy controls (24 boys/25 girls, mean age 11.3 ± 3.4 years). Twenty-two JIA patients were on methotrexate (MTX) therapy (group A) and 27 on biologic drugs (group B). CysC and BUN (respectively, 0.8 ± 0.1 vs. 0.7 ± 0.1 mg/dl; 13.3 ± 2.9 vs. 11.7 ± 1.4 mg/dl) were higher (p ≤ 0.001) whereas creatinine and eGFR (respectively, 0.5 ± 0.1 vs. 0.6 ± 0.1 mg/dl; 99.2 ± 10.5 vs. 122.5 ± 19.8 ml/min/1.73 m2) were lower in JIA children as compared to controls (p p = 0.003). Mean RRI was higher in JIA children than controls (0.7 ± 0.04 vs. 0.6 ± 0.04; p p p p = 0.003) and eGFR (p = 0.001). JIA children had reduced eGFR, increased UAE and higher RRI values, than controls. RRIs were higher in patients on biologic drugs than MTX group and were associated with inflammation indexes and disease state, suggesting a direct effect of the disease.

Published
2022
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8. Kidney function and renal resistive index in children with juvenile idiopathic arthritis

Author

Cafarotti, Alessandro, primary, Marcovecchio, Maria Loredana, additional, Lapergola, Giuseppe, additional, Di Battista, Caterina, additional, Marsili, Manuela, additional, Basilico, Raffaella, additional, Di Donato, Giulia, additional, David, Daniela, additional, Pelliccia, Piernicola, additional, Chiarelli, Francesco, additional, and Breda, Luciana, additional

Published
2022
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18. Reply

Author

Sferrazza Papa, Simone, primary, Attanasi, Marina, additional, Di Pillo, Sabrina, additional, Mohn, Angelika, additional, Chiarelli, Francesco, additional, and Pelliccia, Piernicola, additional

Published
2019
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19. Paediatric liver ultrasound: a pictorial essay

Author

Di Serafino, Marco, primary, Severino, Rosa, additional, Gioioso, Matilde, additional, Rossi, Eugenio, additional, Vezzali, Norberto, additional, Pelliccia, Piernicola, additional, Caprio, Maria Grazia, additional, Acampora, Ciro, additional, Iorio, Raffaele, additional, and Vallone, Gianfrancio, additional

Published
2019
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23. Ultrasonography of the pediatric spleen: a pictorial essay

Author

Di Serafino, Marco, primary, Verde, Francesco, additional, Ferro, Federica, additional, Vezzali, Norberto, additional, Rossi, Eugenio, additional, Acampora, Ciro, additional, Valente, Iacopo, additional, Pelliccia, Piernicola, additional, Speca, Stefania, additional, and Vallone, Gianfranco, additional

Published
2018
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27. A 6-Month-Old Boy with Uncontrollable Dystonic Posture of the Neck

Author

Alessandro Cafarotti, Luciana Breda, Roberta Salvatore, Cinzia Bascietto, Francesco Chiarelli, and Pelliccia Piernicola

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, Complete blood count, Physical examination, medicine.disease, Surgery, Hiatal hernia, Pediatrics, Perinatology and Child Health, Orthopedic surgery, medicine, Vomiting, Medical history, medicine.symptom, business, Torticollis, Sandifer syndrome
Abstract

A6-month-old boy was admitted to the Department of Paediatrics, University of Chieti, Italy, with a 3-month history of uncontrollable dystonic posture of the neck. During the second month of life, the child began to present with a twisting of the neck to one side that persisted for 7 days, after which the abnormal position moved to the other side. The movements were not associated with vomiting, cyanosis, loss of consciousness, tonic or clonic movements, or a post-ictal state. The child’s personal medical history was otherwise unremarkable. Many different specialists, including orthopedic surgeons, otolaryngologists, orthoptists, and ophthalmologists, examined the child and found no evidence of pathology. The investigations included electroencephalograms, magnetic resonance imaging of the head, and X-ray and ultrasound of the neck, but showed no anomalous findings. On admission, physical examination revealed normal growth parameters, vital signs, and neurological findings. After sound stimulation, the child showed difficulty in turning his head to the opposite side and presented resistance to passive mobilization of the neck. A specialist in neurological evaluation demonstrated reduced reaction to the environment and a slight reduction of ocular motility due to torticollis. Laboratory investigations, including a complete blood count; blood electrolytes; serum pyruvate, lactate, and ammonium levels; and urine and blood amino acids, were within normal range. An occult blood test produced a negative result. A paroxysmal non-epileptic event was suspected and 24-hour pH metering revealed postprandial acid reflux of severe grade. Gastroesophageal ultrasound excluded the presence of hiatal hernia. Therapy with ranitidine (8 mg/kg per day) was started, after which symptoms rapidly improved and then disappeared completely within a few days. After 8 months of treatment with ranitidine, the treatment was ended and no problems have recurred. A 6-Month-Old Boy with Uncontrollable Dystonic Posture of the Neck

Published
2014
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28. 90K immunostimulatory glycoprotein in children with juvenile idiopathic arthritis.

Author

Cecamore, Cristina, Marsili, Manuela, Salvatore, Roberta, Troiani, Roberto, D'Egidio, Maurizia, Tinari, Nicola, Pelliccia, Piernicola, Chiarelli, Francesco, Marcovecchio, M. Loredana, and Breda, Luciana

Subjects
GLYCOPROTEINS, JUVENILE idiopathic arthritis, TUMOR necrosis factors, C-reactive protein, CLINICAL trials
Abstract

Objectives: To assess whether circulating levels of 90K glycoprotein are increased in children with juvenile idiopathic arthritis (JIA) at different stages of the disease, compared to healthy controls and to evaluate potential over time changes in its concentrations following treatment with the antitumor-necrosis factor (TNF) drug etanercept. Methods: 90K glycoprotein, C-reactive protein, erythrocyte sedimentation rate, TNF, antinuclear antibodies, rheumatoid factor and the Juvenile Arthritis Disease Activity Score were assessed in 71 children: 23 with newly diagnosed JIA, 23 with established and active JIA and 25 healthy controls. Patients, eligible for anti-TNF treatment, underwent a similar clinical/laboratory assessment after 6- and 12-month etanercept therapy. Results: At baseline, significant differences were found in 90K levels between the three study groups: JIA at onset (157.7 [131.4-241.5] μg/ml), JIA on treatment (90.0 [68.8-120.2] μg/ml) and control group (58.0 [44.5-79.0] μg/ml), (p for trend <.001), with the JIA at onset group showing the highest values. In the JIA on treatment group, following one-year etanercept treatment, a significant reduction in 90K was detected already at 6 months (74.3 [56.0-104.1] μg/ml p = .001) and a further decline was observed at 12 months (49.3 [46.0-67.6] μg/ml p < .001). Conclusion: Our study showed that 90K glycoprotein levels are increased in JIA children compared to healthy controls, suggesting a potential pathogenetic role in the JIA. Besides, 12 months of therapy with etanercept can reduce 90K levels. [ABSTRACT FROM AUTHOR]

Published
2018
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29. Protein-losing enteropathy in an infant with rotavirus infection.

Author

Parisi, Adriana, Cafarotti, Alessandro, Salvatore, Roberta, Pelliccia, Piernicola, Breda, Luciana, and Chiarelli, Francesco

Subjects
PROTEIN-losing enteropathy, BLOOD protein disorder diagnosis, ROTAVIRUS diseases, HYPOPROTEINEMIA, DIARRHEA in children, FEVER in children, EDEMA, PATIENTS, DIAGNOSIS
Abstract

Protein-losing enteropathy (PLE) is a rare gastro-intestinal complication characterised by intestinal loss of proteins with consequent hypoproteinaemia and generalised oedema. Rotavirus infection associated with PLE in children has rarely been reported. A 6-month-old girl presented with diarrhoea, fever and generalised oedema. Total serum proteins were 34 g/L (61-79) and plasma albumin 16.8 g/L (40-50), serum sodium was 126 mmol/L and there was mild metabolic alkalosis (pH 7.46). Stool for alpha-1 antitrypsin was >1.2 mg/g (<0.6) which supported the diagnosis of PLE. Stool examination demonstrated the presence of rotavirus antigen by the rapid immunochromatographic test. Abdominal ultrasound showed bowel distension and intestinal wall thickening with a small amount of ascites. Echocardiography excluded pericardial effusion. Two albumin infusions (1 g/kg) were required to sustain normal serum albumin levels. Over the next 2 weeks, there was gradual normalisation of stools and progressive reduction of oedema. In children with acute and symptomatic PLE, rotavirus should be considered in the differential diagnosis. The availability of the rapid immunochromatographic test facilitates the diagnosis. In most cases, supportive care alone is sufficient, but albumin infusions may be required in more severely affected children. [ABSTRACT FROM AUTHOR]

Published
2018
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30. Prevalence of SARS-CoV-2-IgG Antibodies in Children with CKD or Immunosuppression

Author

Morello, William, Mastrangelo, Antonio, Guzzo, Isabella, Cusinato, Lisa, Annicchiarico Petruzzelli, Luigi, Benevenuta, Chiara, Martelli, Laura, Dall’Amico, Roberto, Vianello, Federica Alessandra, Puccio, Giuseppe, Massella, Laura, Benetti, Elisa, Pecoraro, Carmine, Peruzzi, Licia, Montini, Giovanni, Peruzzi, Licia, Petruzzelli, Luigi Annicchiarico, Becherucci, Francesca, Benetti, Elisa, Benevenuta, Chiara, Brugnara, Milena, Casadio, Luca, Chimenz, Roberto, Conti, Giovanni, Corrado, Ciro, D’Agostino, Viviana, Dall’Amico, Roberto, Gianoglio, Bruno, Giordano, Mario, Gualeni, Chiara, Guarino, Stefano, Guzzo, Isabella, La Manna, Angela, La Scola, Claudio, Martelli, Laura, Massella, Laura, Mastrangelo, Antonio, Materassi, Marco, Montini, Giovanni, Morello, William, Pani, Antonello, Papalia, Teresa, Pasini, Andrea, Pecoraro, Carmine, Pelliccia, Piernicola, Pennesi, Marco, Pugliese, Fabrizio, Ratsch, Ilse Maria, Romagnani, Paola, Roperto, Rosa Maria, Tamburello, Chiara, Vergine, Gianluca, Vergori, Antonio, Vianello, Federica Alessandra, and Vidal, Enrico

Published
2021
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35. Genital swelling in an adolescent patient

Author

Savino, Alessandra, primary, Pelliccia, Piernicola, additional, Breda, Luciana, additional, Verini, Marcello, additional, Salladini, Carmela, additional, Neri, Matteo, additional, Angelucci, Domenico, additional, and Chiarelli, Francesco, additional

Published
2005
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36. Ultrasonography of the pediatric spleen: a pictorial essay

Author

Piernicola Pelliccia, Gianfranco Vallone, Francesco Verde, Iacopo Valente, Eugenio Rossi, Ciro Acampora, Stefania Speca, Marco Di Serafino, Federica Ferro, Norberto Vezzali, Di Serafino, Marco, Verde, Francesco, Ferro, Federica, Vezzali, Norberto, Rossi, Eugenio, Acampora, Ciro, Valente, Iacopo, Pelliccia, Piernicola, Speca, Stefania, and Vallone, Gianfranco

Subjects
medicine.medical_specialty, Congenital anomalies, Focal splenic lesions, Pediatric sonography, Splenomegaly, Trauma, Tumors, Infarction, Focal splenic lesion, Spleen, Congenital anomalie, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Blunt, Internal Medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Hemoperitoneum, Child, Pathological, Splenic Diseases, Ultrasonography, Tumor, business.industry, Ultrasound, General Medicine, medicine.disease, medicine.anatomical_structure, Abdominal trauma, 030220 oncology & carcinogenesis, Splenic Disease, Pictorial Essay, Radiology, medicine.symptom, business, Human
Abstract

In infants and children, the spleen is involved in many pathological processes, whether those processes are isolated or related to systemic diseases. Pathology of the pediatric spleen includes congenital anomalies, splenomegaly, trauma, focal lesions, infarction, and tumors. Ultrasonography (US) is a widely available, fast, noninvasive imaging technique to assess the size, shape, and position of the spleen, as well as to define splenic echotexture. US is capable of screening for splenic disorders without the risk of ionizing radiation; it is the initial imaging examination performed to evaluate suspected splenic pathology, providing clinicians with helpful decisional support. US plays an important role in the detection of even very small amounts of hemoperitoneum, a herald of significant abdominal organ injury, in pediatric blunt abdominal trauma. Moreover, contrast-enhanced US may allow early detection of splenic injuries, ideally minimizing children's risk from radiation exposure. This pictorial essay illustrates the normal ultrasound appearance of the pediatric spleen and the sonographic findings which may guide clinicians to a correct diagnosis of pathologic conditions.

Published
2019

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