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2. Development of a pediatric differentiated thyroid carcinoma registry within the EuRRECa project: rationale and protocol

Author

Clement, S C, primary, Visser, W E, additional, Lebbink, C A, additional, Albano, D, additional, Claahsen-van der Grinten, H L, additional, Czarniecka, A, additional, Dias, R P, additional, Dierselhuis, M P, additional, Dzivite-Krisane, I, additional, Elisei, R, additional, Garcia-Burillo, A, additional, Izatt, L, additional, Kanaka-Gantenbein, C, additional, Krude, H, additional, Lamartina, L, additional, Lorenz, K, additional, Luster, M, additional, Navardauskaitė, R, additional, Negre Busó, M, additional, Newbold, K, additional, Peeters, R P, additional, Pellegriti, G, additional, Piccardo, A, additional, Priego, A L, additional, Redlich, A, additional, de Sanctis, L, additional, Sobrinho-Simões, M, additional, van Trotsenburg, A S P, additional, Verburg, F A, additional, Vriens, M, additional, Links, T P, additional, Ahmed, S F, additional, and van Santen, H M, additional

Published
2023
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3. Development of a pediatric differentiated thyroid carcinoma registry within the EuRRECa project:rationale and protocol

Author

Clement, S. C., Visser, W. E., Lebbink, C. A., Albano, D., Claahsen-Van der Grinten, H. L., Czarniecka, A., Dias, R. P., Dierselhuis, M. P., Dzivite-Krisane, I., Elisei, R., Garcia-Burillo, A., Izatt, L., Kanaka-Gantenbein, C., Krude, H., Lamartina, L., Lorenz, K., Luster, M., Navardauskaitė, R., Negre Busó, M., Newbold, K., Peeters, R. P., Pellegriti, G., Piccardo, A., Priego, A. L., Redlich, A., de Sanctis, L., Sobrinho-Simões, M., van Trotsenburg, A. S.P., Verburg, F. A., Vriens, M., Links, T. P., Ahmed, S. F., van Santen, H. M., Clement, S. C., Visser, W. E., Lebbink, C. A., Albano, D., Claahsen-Van der Grinten, H. L., Czarniecka, A., Dias, R. P., Dierselhuis, M. P., Dzivite-Krisane, I., Elisei, R., Garcia-Burillo, A., Izatt, L., Kanaka-Gantenbein, C., Krude, H., Lamartina, L., Lorenz, K., Luster, M., Navardauskaitė, R., Negre Busó, M., Newbold, K., Peeters, R. P., Pellegriti, G., Piccardo, A., Priego, A. L., Redlich, A., de Sanctis, L., Sobrinho-Simões, M., van Trotsenburg, A. S.P., Verburg, F. A., Vriens, M., Links, T. P., Ahmed, S. F., and van Santen, H. M.

Abstract

Background: Although differentiated thyroid carcinoma (DTC) is the most frequent endocrine pediatric cancer, it is rare in childhood and adolescence. While tumor persistence and recurrence are not uncommon, mortality remains extremely low. Complications of treatment are however reported in up to 48% of the survivors. Due to the rarity of the disease, current treatment guidelines are predominantly based on the results of small observational retrospective studies and extrapolations from results in adult patients. In order to develop more personalized treatment and follow-up strategies (aiming to reduce complication rates), there is an unmet need for uniform international prospective data collection and clinical trials. Methods and analysis: The European pediatric thyroid carcinoma registry aims to collect clinical data for all patients ≤18 years of age with a confirmed diagnosis of DTC who have been diagnosed, assessed, or treated at a participating site. This registry will be a component of the wider European Registries for Rare Endocrine Conditions project which has close links to Endo-ERN, the European Reference Network for Rare Endocrine Conditions. A multidisciplinary expert working group was formed to develop a minimal dataset comprising information regarding demographic data, diagnosis, treatment, and outcome. We constructed an umbrella-type registry, with a detailed basic dataset. In the future, this may provide the opportunity for research teams to integrate clinical research questions. Ethics and dissemination: Written informed consent will be obtained from all participants and/or their parents/guardians. Summaries and descriptive analyses of the registry will be disseminated via conference presentations and peer-reviewed publications.

Published
2023

4. Development of a pediatric differentiated thyroid carcinoma registry within the EuRRECa project: rationale and protocol

Author

Endocrinologie onderzoek, Arts-assistenten Kinderen, CTI Van der Vlist, Cancer, Heelkunde Opleiding, MS CGO, Endocrinologie patientenzorg, Brain, Child Health, Clement, S. C., Visser, W. E., Lebbink, C. A., Albano, D., Claahsen-Van der Grinten, H. L., Czarniecka, A., Dias, R. P., Dierselhuis, M. P., Dzivite-Krisane, I., Elisei, R., Garcia-Burillo, A., Izatt, L., Kanaka-Gantenbein, C., Krude, H., Lamartina, L., Lorenz, K., Luster, M., Navardauskaitė, R., Negre Busó, M., Newbold, K., Peeters, R. P., Pellegriti, G., Piccardo, A., Priego, A. L., Redlich, A., de Sanctis, L., Sobrinho-Simões, M., van Trotsenburg, A. S.P., Verburg, F. A., Vriens, M., Links, T. P., Ahmed, S. F., van Santen, H. M., Endocrinologie onderzoek, Arts-assistenten Kinderen, CTI Van der Vlist, Cancer, Heelkunde Opleiding, MS CGO, Endocrinologie patientenzorg, Brain, Child Health, Clement, S. C., Visser, W. E., Lebbink, C. A., Albano, D., Claahsen-Van der Grinten, H. L., Czarniecka, A., Dias, R. P., Dierselhuis, M. P., Dzivite-Krisane, I., Elisei, R., Garcia-Burillo, A., Izatt, L., Kanaka-Gantenbein, C., Krude, H., Lamartina, L., Lorenz, K., Luster, M., Navardauskaitė, R., Negre Busó, M., Newbold, K., Peeters, R. P., Pellegriti, G., Piccardo, A., Priego, A. L., Redlich, A., de Sanctis, L., Sobrinho-Simões, M., van Trotsenburg, A. S.P., Verburg, F. A., Vriens, M., Links, T. P., Ahmed, S. F., and van Santen, H. M.

Published
2023

16. Real-world efficacy and safety of lenvatinib: data from a compassionate use in the treatment of radioactive iodine-refractory differentiated thyroid cancer patients in Italy

Author

Locati, L.D., primary, Piovesan, A., additional, Durante, C., additional, Bregni, M., additional, Castagna, M.G., additional, Zovato, S., additional, Giusti, M., additional, Ibrahim, T., additional, Puxeddu, E., additional, Fedele, G., additional, Pellegriti, G., additional, Rinaldi, G., additional, Giuffrida, D., additional, Verderame, F., additional, Bertolini, F., additional, Bergamini, C., additional, Nervo, A., additional, Grani, G., additional, Rizzati, S., additional, Morelli, S., additional, Puliafito, I., additional, and Elisei, R., additional

Published
2019
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20. Italian consensus on diagnosis and treatment of differentiated thyroid cancer: joint statements of six Italian societies

Author

Pacini, F., Basolo, F., Bellantone, Rocco Domenico Alfonso, Boni, G., Cannizzaro, M. A., De Palma, M., Durante, C., Elisei, R., Fadda, Guido, Frasoldati, A., Fugazzola, L., Guglielmi, Rinaldo, Lombardi, Celestino Pio, Miccoli, P., Papini, Enrico, Pellegriti, G., Pezzullo, L., Pontecorvi, Alfredo, Salvatori, Massimo, Seregni, E., Vitti, P., Bellantone, R. (ORCID:0000-0002-0844-3469), Fadda, G. (ORCID:0000-0003-2013-7293), Guglielmi, R., Lombardi, C. P. (ORCID:0000-0001-8910-6693), Papini, E., Pontecorvi, A. (ORCID:0000-0003-0570-6865), Salvatori, M. (ORCID:0000-0003-0208-1273), Pacini, F., Basolo, F., Bellantone, Rocco Domenico Alfonso, Boni, G., Cannizzaro, M. A., De Palma, M., Durante, C., Elisei, R., Fadda, Guido, Frasoldati, A., Fugazzola, L., Guglielmi, Rinaldo, Lombardi, Celestino Pio, Miccoli, P., Papini, Enrico, Pellegriti, G., Pezzullo, L., Pontecorvi, Alfredo, Salvatori, Massimo, Seregni, E., Vitti, P., Bellantone, R. (ORCID:0000-0002-0844-3469), Fadda, G. (ORCID:0000-0003-2013-7293), Guglielmi, R., Lombardi, C. P. (ORCID:0000-0001-8910-6693), Papini, E., Pontecorvi, A. (ORCID:0000-0003-0570-6865), and Salvatori, M. (ORCID:0000-0003-0208-1273)

Abstract

Background: Thyroid nodules are a common clinical problem, and differentiated thyroid cancer is becoming increasingly prevalent. Methods: Six scientific Italian societies entitled to cure thyroid cancer patients (the Italian Thyroid Association, the Medical Endocrinology Association, the Italian Society of Endocrinology, the Italian Association of Nuclear Medicine and Molecular Imaging, the Italian Society of Unified Endocrine Surgery and the Italian Society of Anatomic Pathology and Diagnostic Cytology) felt the need to develop a consensus report based on significant scientific advances occurred in the field. Objective: The document includes recommendations regarding initial evaluation of thyroid nodules, clinical and ultrasound criteria for fine-needle aspiration biopsy, initial management of thyroid cancer including staging and risk assessment, surgical management, radioiodine remnant ablation, and levothyroxine therapy, short-term and long-term follow-up strategies, and management of recurrent and metastatic disease. The objective of this consensus is to inform clinicians, patients, researchers, and health policy makers about the best strategies (and their limitations) relating to the diagnosis and treatment of differentiated thyroid cancer.

Published
2018

21. Italian consensus on diagnosis and treatment of differentiated thyroid cancer: joint statements of six Italian societies

Author

Pacini, F., primary, Basolo, F., additional, Bellantone, R., additional, Boni, G., additional, Cannizzaro, M. A., additional, De Palma, M., additional, Durante, C., additional, Elisei, R., additional, Fadda, G., additional, Frasoldati, A., additional, Fugazzola, L., additional, Guglielmi, R., additional, Lombardi, C. P., additional, Miccoli, P., additional, Papini, E., additional, Pellegriti, G., additional, Pezzullo, L., additional, Pontecorvi, A., additional, Salvatori, M., additional, Seregni, E., additional, and Vitti, P., additional

Published
2018
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26. BRAF(V600E) MUTATION AND THE BIOLOGY OF PAPILLARY THYROID CANCER

Author

Frasca, Francesco, Nucera, C, Pellegriti, G, Gangemi, P, Attard, M, Stella, M, Loda, M, Vella, V, Giordano, C, Trimarchi, F, Mazzon, E, Belfiore, A, Vigneri, R., Vella, Veronica, FRASCA, F, NUCERA, C, PELLEGRITI, G, GANGEMI, P, ATTARD, M, STELLA, M, LODA, M, VELLA, V, GIORDANO, C, TRIMARCHI, F, MAZZON, E, BELFIORE, A, and VIGNERI, R

Subjects
Male, Cancer Research, endocrine system diseases, Endocrinology, Diabetes and Metabolism, medicine.disease_cause, thyroid, Papillary thyroid cancer, Settore MED/13 - Endocrinologia, Immunoenzyme Techniques, Endocrinology, thyroid cancer, skin and connective tissue diseases, Sicily, Microdissection, BRAF(V600E), Univariate analysis, Mutation, Geography, Reverse Transcriptase Polymerase Chain Reaction, Thyroid, BRAF V600, Papillary Thyroid Cancer, Middle Aged, humanities, medicine.anatomical_structure, Matrix Metalloproteinase 9, Oncology, Lymphatic Metastasis, Disease Progression, Female, Proto-Oncogene Proteins B-raf, Papillary thyroid cancer, BRAF(V600E), thyroid, thyroid cancer, Biology, Thyroid carcinoma, medicine, Carcinoma, Humans, Neoplasm Invasiveness, RNA, Messenger, Thyroid Neoplasms, neoplasms, DNA Primers, Lasers, Papillary thyroid cancer, BRAF, medicine.disease, Carcinoma, Papillary, digestive system diseases, Cancer research, V600E, Follow-Up Studies
Abstract

BRAF((V600E)) mutation is the most frequent genetic alteration in papillary thyroid carcinomas (PTCs) that are 80-90% of all thyroid cancers. We evaluated the relationship between BRAF((V600E)) and tumor, host, and environmental factors in PTCs from all geographical areas of Sicily. By PCR, BRAF((V600E)) was investigated in a series of 323 PTCs diagnosed in 2002-2005. The correlation between clinicopathological tumor, host, and environmental characteristics and the presence of BRAF((V600E)) were evaluated by both univariate and multivariate analyses. BRAF((V600E)) was found in 38.6% PTCs, with a 52% frequency in the classical PTCs and 26.4% in the tall cell variant. Univariate analysis indicated that BRAF((V600E)) was associated with greater tumor size (P=0.0048), extra-thyroid invasion (P

Published
2008

28. 'Sicilian Register of Thyroid Cancer': Descriptive, clinical and of risk factors epidemiology. Preliminary data

Author

PELLEGRITI G, S. ARENA, C. SCOLLO, R. VIGNERI, A. VIOLI, F. VERMIGLIO, P. RICHIUSA, A. MANIGLIA, L. GAMBINO, G. D'AZZO', M. ATTARD, G. DARDANONI, A. MIRA, F. TRIMARCHI J. ENDOCRINOL INVEST SUPPL TO NO, GIORDANO, Carla, PELLEGRITI G, S ARENA, C SCOLLO, R VIGNERI, A VIOLI, F VERMIGLIO, P RICHIUSA, GIORDANO C, A MANIGLIA, L GAMBINO, G D'AZZO', M ATTARD, G DARDANONI, A MIRA, and F TRIMARCHI J ENDOCRINOL INVEST SUPPL TO NO

Published
2004

30. The tall cell variant of papillary thyroid carcinoma: clinical and pathological features and outcomes

Author

Regalbuto, Concetto, Malandrino, P, Frasca, Francesco, Pellegriti, G, Le Moli, R, Vigneri, R, and Pezzino, V.

Subjects
Adult, Male, Adolescent, Carcinoma, Middle Aged, Prognosis, Carcinoma, Papillary, Young Adult, Treatment Outcome, Thyroid Cancer, Papillary, Thyroidectomy, Humans, Female, Neoplasm Invasiveness, Thyroid Neoplasms, Aged, Follow-Up Studies, Neoplasm Staging, Retrospective Studies
Abstract

The tall cell variant (TCV) is a relatively rare variant of papillary thyroid cancer. Since a controversy exists whether or not the TCV has a worse outcome, the aim of our study was to retrospectively compare the clinicopathological features and outcomes in a group of TCV patients and a larger group of patients with classical papillary thyroid carcinoma (cPTC).Data from 30 TCV and 293 cPTC patients were analyzed. Among the 293 cPTC, we also selected a "high-risk" cPTC group (no.=103) that was treated with the same protocol used for the TCV patients. All data were managed by Cox analysis.Compared to all cPTC patients, TCV subjects displayed only a significantly higher rate of extrathyroid extension. At multivariate analysis, TCV was not an independent variable for the prediction of a high risk of persistent/recurrent disease. At the last follow-up observation, there was no difference in the disease status between the TCV and all cPTC patients. Moreover, "high-risk" cPTC patients had a significant increase in persistent/recurrent disease.In our study, although the TCV histotype is associated with a higher prevalence of extrathyroid extension, it is characterized by an outcome that is not significantly different from that of all cPTC patients and is more favorable than that of "high-risk" cPTC patients. Only those TCV patients classified as "high risk" based on specific pathological and clinical features, according to current guidelines, should be treated aggressively, such as with a total thyroidectomy, neck lymph node dissection or ablative radioiodine treatment.

Published
2012

36. European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium

Author

Pacini, F., Schlumberger, M., Dralle, H., Elisei, R., Smit, J. W. A., Wiersinga, W., Moreno-Reyes, R., Van den Bruel, A., Zira, C., Feldt-Rasmussen, U., Godballe, C., Corone, C., Borson-Charzot, F., Reiners, C., Alevizaki, M., Duntas, L., Vlassopoulou, B., Esik, O., Mezosi, E., Moriarty, M. J., Smyth, P., Cohen, O., Krausz, Y., Pellegriti, G., Castagna, M. G., Marga, M., Bioro, T., Jarzab, B., Carrilho, F., de Castro, J. J., Limbert, E. S., Ioachim, D., Mogos, V., Ursu, H., Roumiantsev, P., Troshina, E., Hnilica, P., Besic, N., Zagar, I., Gomez, J. M., Sanchez-Franco, F., Berg, G., Tennvall, J., Wallin, G. K., Meier, C. A., Links, T. P., Ayvaz, G., Uysal, A. R., Cherenko, S., Larin, O., and Harmer, C.

Subjects
medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Thyroid Gland, Adenocarcinoma, Thyroglobulin, Thyroid carcinoma, Iodine Radioisotopes, Institut Gustave Roussy, Endocrinology, Internal medicine, Follicular phase, Adenocarcinoma, Follicular, medicine, University medical, Thyroid Neoplasms, Thyroid Nodule, Metabolic disease, Autoantibodies, Neck, Ultrasonography, Thyroid cancer, business.industry, Thyroid, Follicular, General Medicine, medicine.disease, humanities, medicine.anatomical_structure, business
Abstract

European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium Furio Pacini, Martin Schlumberger, Henning Dralle, Rossella Elisei, Johannes W A Smit, Wilmar Wiersinga and the European Thyroid Cancer Taskforce Section of Endocrinology and Metabolism, University of Siena, Via Bracci, 53100 Siena, Italy, Service de Medicine Nucleaire, Institut Gustave Roussy, Villejuif, France, Department of General, Visceral and Vascular Surgery, University of Halle, Germany, Department of Endocrinology, University of Pisa, Italy, Department of Endocrinology and Metabolic Disease, Leiden University Medical Center, The Netherlands and Department of Endocrinology and Metabolism, University of Amsterdam, The Netherlands

Published
2006

46. Long-term outcome of patients with insular carcinoma of the thyroid

Author

Pellegriti, G, Giuffrida, D, Scollo, R, Vigneri, R, Regalbuto, Concetto, Squatrito, Sebastiano, and Belfiore, A.

Subjects
poorly differentiated thyroid cancer, Insular thyroid cancer, Insular thyroid cancer, poorly differentiated thyroid cancer
Published
2002

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