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610 results on '"Pellegrini, Luca"'

10. Feasibility, acceptability and practicality of transcranial stimulation in obsessive compulsive symptoms (FEATSOCS): A randomised controlled crossover trial

Author

Fineberg, Naomi A., Cinosi, Eduardo, Smith, Megan V.A., Busby, Amanda D., Wellsted, David, Huneke, Nathan T.M., Garg, Kabir, Aslan, Ibrahim H., Enara, Arun, Garner, Matthew, Gordon, Robert, Hall, Natalie, Meron, Daniel, Robbins, Trevor W., Wyatt, Solange, Pellegrini, Luca, and Baldwin, David S.

Published
2023
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11. Differential effects of sertraline and cognitive behavioural therapy on behavioural inhibition in patients with obsessive compulsive disorder

Author

Reid, Jemma E., primary, Pellegrini, Luca, additional, Drummond, Lynne, additional, Varlakova, Yana, additional, Shahper, Sonia, additional, Baldwin, David S., additional, Manson, Christopher, additional, Chamberlain, Samuel R., additional, Robbins, Trevor W., additional, Wellsted, David, additional, and Fineberg, Naomi A., additional

Published
2024
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13. Advances in problematic usage of the internet research – A narrative review by experts from the European network for problematic usage of the internet

Author

Fineberg, Naomi A., Menchón, José M., Hall, Natalie, Dell'Osso, Bernardo, Brand, Matthias, Potenza, Marc N., Chamberlain, Samuel R., Cirnigliaro, Giovanna, Lochner, Christine, Billieux, Joël, Demetrovics, Zsolt, Rumpf, Hans Jürgen, Müller, Astrid, Castro-Calvo, Jesús, Hollander, Eric, Burkauskas, Julius, Grünblatt, Edna, Walitza, Susanne, Corazza, Ornella, King, Daniel L., Stein, Dan J., Grant, Jon E., Pallanti, Stefano, Bowden-Jones, Henrietta, Ameringen, Michael Van, Ioannidis, Konstantinos, Carmi, Lior, Goudriaan, Anna E., Martinotti, Giovanni, Sales, Célia M.D., Jones, Julia, Gjoneska, Biljiana, Király, Orsolya, Benatti, Beatrice, Vismara, Matteo, Pellegrini, Luca, Conti, Dario, Cataldo, Ilaria, Riva, Gianluigi M., Yücel, Murat, Flayelle, Maèva, Hall, Thomas, Griffiths, Morgan, and Zohar, Joseph

Published
2022
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19. Prevalence and correlates of current suicide risk in an international sample of OCD adults: A report from the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS) network and Obsessive Compulsive and Related Disorders Network (OCRN) of the European College of Neuropsychopharmacology

Author

Benatti, Beatrice, Dell'Osso, Bernardo, Shen, Hanyang, Filippou-Frye, Maria, Varias, Andrea, Sanchez, Catherine, Jo, Booil, Hollander, Eric, Fineberg, Naomi A., Stein, Dan J., Nicolini, Humberto, Lanzagorta, Nuria, Marazziti, Donatella, Pallanti, Stefano, Van Ameringen, Michael, Lochner, Christine, Karamustafalioglu, Oguz, Hranov, Luchezar, Figee, Martin, Drummond, Lynne, Grant, Jon E., Denys, Damiaan, Fontenelle, Leonardo F., Menchon, Jose M., Zohar, Joseph, Pellegrini, Luca, and Rodriguez, Carolyn I.

Published
2021
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21. A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death

Author

Scott, Duncan E., Francis-Newton, Nicola J., Marsh, May E., Coyne, Anthony G., Fischer, Gerhard, Moschetti, Tommaso, Bayly, Andrew R., Sharpe, Timothy D., Haas, Kalina T., Barber, Lorraine, Valenzano, Chiara R., Srinivasan, Rajavel, Huggins, David J., Lee, Miyoung, Emery, Amy, Hardwick, Bryn, Ehebauer, Matthias, Dagostin, Claudio, Esposito, Alessandro, Pellegrini, Luca, Perrior, Trevor, McKenzie, Grahame, Blundell, Tom L., Hyvönen, Marko, Skidmore, John, Venkitaraman, Ashok R., and Abell, Chris

Published
2021
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24. CryoEM insights into RNA primer synthesis by the human primosome.

Author

Yin, Zhan, Kilkenny, Mairi L., Ker, De‐Sheng, and Pellegrini, Luca

Subjects
RNA synthesis, GENE rearrangement, DNA polymerases, DNA replication, DNA synthesis, STRUCTURAL dynamics, DEOXYRIBOZYMES, DNA primers
Abstract

Eukaryotic DNA replication depends on the primosome – a complex of DNA polymerase alpha (Pol α) and primase – to initiate DNA synthesis by polymerisation of an RNA–DNA primer. Primer synthesis requires the tight coordination of primase and polymerase activities. Recent cryo‐electron microscopy (cryoEM) analyses have elucidated the extensive conformational transitions required for RNA primer handover between primase and Pol α and primer elongation by Pol α. Because of the intrinsic flexibility of the primosome, however, structural information about the initiation of RNA primer synthesis is still lacking. Here, we capture cryoEM snapshots of the priming reaction to reveal the conformational trajectory of the human primosome that brings DNA primase subunits 1 and 2 (PRIM1 and PRIM2, respectively) together, poised for RNA synthesis. Furthermore, we provide experimental evidence for the continuous association of primase subunit PRIM2 with the RNA primer during primer synthesis, and for how both initiation and termination of RNA primer polymerisation are licenced by specific rearrangements of DNA polymerase alpha catalytic subunit (POLA1), the polymerase subunit of Pol α. Our findings fill a critical gap in our understanding of the conformational changes that underpin the synthesis of the RNA primer by the primosome. Together with existing evidence, they provide a complete description of the structural dynamics of the human primosome during DNA replication initiation. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Unveiling the Burden of Drug-Induced Impulsivity: A Network Analysis of the FDA Adverse Event Reporting System

Author

Fusaroli, Michele, primary, Polizzi, Stefano, additional, Menestrina, Luca, additional, Giunchi, Valentina, additional, Pellegrini, Luca, additional, Raschi, Emanuel, additional, Weintraub, Daniel, additional, Recanatini, Maurizio, additional, Castellani, Gastone, additional, De Ponti, Fabrizio, additional, and Poluzzi, Elisabetta, additional

Published
2023
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31. A metal ion-dependent mechanism of RAD51 nucleoprotein filament disassembly

Author

Pellegrini, Luca, Pellegrini, Luca [0000-0002-9300-497X], and Apollo - University of Cambridge Repository

Subjects
Molecular biology, FOS: Biological sciences, Genetics, 3101 Biochemistry and Cell Biology, Structural biology, 31 Biological Sciences
Abstract

The RAD51 ATPase polymerises on single-stranded DNA to form nucleoprotein filaments (NPFs) that are critical intermediates in the reaction of Homologous Recombination. ATP binding maintains the NPF in a competent conformation for strand pairing and exchange. Once strand exchange is completed, ATP hydrolysis licenses the filament for disassembly. Here we show that the ATP-binding site of the RAD51 NPF contains a second metal ion. In the presence of ATP, the metal ion promotes the local folding of RAD51 into the conformation required for DNA binding. The metal ion is absent in the ADP-bound RAD51 filament, that rearranges in a conformation incompatible with DNA binding. The presence of the second metal ion explains how RAD51 couples the nucleotide state of the filament to DNA binding. We propose that loss of the second metal ion upon ATP hydrolysis drives RAD51 dissociation from the DNA and weakens filament stability, contributing to NPF disassembly.

Published
2023

32. Flexible tethering of primase and DNA Pol α in the eukaryotic primosome

Author

Núñez-Ramírez, Rafael, Klinge, Sebastian, Sauguet, Ludovic, Melero, Roberto, Recuero-Checa, María A, Kilkenny, Mairi, Perera, Rajika L, García-Alvarez, Begoña, Hall, Richard J, Nogales, Eva, Pellegrini, Luca, and Llorca, Oscar

Subjects
Biological Sciences, Ecology, Genetics, 1.1 Normal biological development and functioning, Underpinning research, Generic health relevance, Amino Acid Sequence, DNA Polymerase I, DNA Primase, Models, Molecular, Molecular Sequence Data, Protein Subunits, RNA, Saccharomyces cerevisiae, Environmental Sciences, Information and Computing Sciences, Developmental Biology, Biological sciences, Chemical sciences, Environmental sciences
Abstract

The Pol α/primase complex or primosome is the primase/polymerase complex that initiates nucleic acid synthesis during eukaryotic replication. Within the primosome, the primase synthesizes short RNA primers that undergo limited extension by Pol α. The resulting RNA-DNA primers are utilized by Pol δ and Pol ε for processive elongation on the lagging and leading strands, respectively. Despite its importance, the mechanism of RNA-DNA primer synthesis remains poorly understood. Here, we describe a structural model of the yeast primosome based on electron microscopy and functional studies. The 3D architecture of the primosome reveals an asymmetric, dumbbell-shaped particle. The catalytic centers of primase and Pol α reside in separate lobes of high relative mobility. The flexible tethering of the primosome lobes increases the efficiency of primer transfer between primase and Pol α. The physical organization of the primosome suggests that a concerted mechanism of primer hand-off between primase and Pol α would involve coordinated movements of the primosome lobes. The first three-dimensional map of the eukaryotic primosome at 25 Å resolution provides an essential structural template for understanding initiation of eukaryotic replication.

Published
2011

35. Episodic obsessive-compulsive disorder and bipolar spectrum disorder: new evidence from a large Italian OCD sample.

Author

Bramante, Stefano, Rigardetto, Sylvia, Borgogno, Roberta, Mehanović, Emina, Pellegrini, Luca, Albert, Umberto, and Maina, Giuseppe

Subjects
SCIENTIFIC observation, CHRONIC diseases, MULTIPLE regression analysis, MULTIVARIATE analysis, CROSS-sectional method, FISHER exact test, T-test (Statistics), SEVERITY of illness index, CHI-squared test, DESCRIPTIVE statistics, SOCIODEMOGRAPHIC factors, OBSESSIVE-compulsive disorder, BIPOLAR disorder, COMORBIDITY
Abstract

Objectives: Obsessive-compulsive Disorder (OCD) has been considered to be a chronic illness; however, some authors described a subtype of OCD characterised by symptom-free periods of time: Episodic-OCD (E-OCD). Only few studies focussed on this subtype of the disorder. the objectives of this research were to study the association between the episodic course of the disorder and lifetime psychiatric comorbidities and to investigate socio-demographic and other clinical features correlated to the episodic course. Methods: the sample is composed of adult OCD patients. the course was defined episodic when at least one circumscribed symptom-free interval of at least 6 months was present. the sample was divided into two subgroups: Episodic-OCD and chronic-OCD. Differences between groups were analysed with Student's t-test, χ² tests, Fisher test and multivariate logistic regression. Results: Data regarding 585 individuals were collected. 14.2% (N = 83) of our sample had an episodic course. Bipolar I comorbid disorder, abrupt onset, lower severity of illness and lower rates of repeating compulsions were associated with the likelihood of having an E-OCD. Conclusions: Our findings confirm that a significant proportion of OCD patients have an episodic course and that E-OCD could represent a specific endophenotype. [ABSTRACT FROM AUTHOR]

Published
2023
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37. Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells

Author

Dev, Harveer, Chiang, Ting-Wei Will, Lescale, Chloe, de Krijger, Inge, Martin, Alistair G., Pilger, Domenic, Coates, Julia, Sczaniecka-Clift, Matylda, Wei, Wenming, Ostermaier, Matthias, Herzog, Mareike, Lam, Jonathan, Shea, Abigail, Demir, Mukerrem, Wu, Qian, Yang, Fengtang, Fu, Beiyuan, Lai, Zhongwu, Balmus, Gabriel, Belotserkovskaya, Rimma, Serra, Violeta, O’Connor, Mark J., Bruna, Alejandra, Beli, Petra, Pellegrini, Luca, Caldas, Carlos, Deriano, Ludovic, Jacobs, Jacqueline J. L., Galanty, Yaron, and Jackson, Stephen P.

Published
2018
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42. Problematic Usage of the Internet and other digital addictions in people with psychiatric disorders – a scoping review and meta-analysis

Author

Laws, Keith R., Gale, Tim, Fineberg, Naomi, Folorunso Bodunwa, Hopkins, Janine, Radhakrishnan, Tharunkrishnan, Pellegrini, Luca, Olalekan Aina, Mpavaenda, Davis, Lee, Monika, and Eberechi Chris-Okoro

Subjects
digital addictions, Psychiatric patients, Internet Addiction, Medicine and Health Sciences, behavioural addiction, Mental health, Social and Behavioral Sciences, Psychiatric disorders, Problematic Usage of the Internet (PUI)
Abstract

This scoping review aims to capture the data available from the published literature on the frequency and impact of PUI in psychiatric patients. Of note, some forms of offline gaming do not involve the active use of the Internet beyond an initial download of software, while some forms of gambling combine online and offline methods using mobile phones. As these behaviours may be just as disabling as fully online versions, we will include studies investigating all forms of digital addictive behaviours involving psychiatric patients.

Published
2023
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44. Coming together to define membrane contact sites

Author

Scorrano, Luca, De Matteis, Maria Antonietta, Emr, Scott, Giordano, Francesca, Hajnóczky, György, Kornmann, Benoît, Lackner, Laura L., Levine, Tim P., Pellegrini, Luca, Reinisch, Karin, Rizzuto, Rosario, Simmen, Thomas, Stenmark, Harald, Ungermann, Christian, and Schuldiner, Maya

Published
2019
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45. Effects of exercise on obsessive-compulsive disorder symptoms: a systematic review and meta-analysis.

Author

Bottoms, Lindsay, Prat Pons, Montserrat, Fineberg, Naomi A., Pellegrini, Luca, Fox, Oliver, Wellsted, David, Drummond, Lynne M., Reid, Jemma, Baldwin, David S., Hou, Ruihua, Chamberlain, Samuel, Sireau, Nick, Grohmann, Dominique, and Laws, Keith R.

Subjects
PREVENTION of mental depression, ANXIETY prevention, ONLINE information services, MEDICAL databases, META-analysis, CONFIDENCE intervals, SYSTEMATIC reviews, TREATMENT effectiveness, PRE-tests & post-tests, PHYSICAL activity, DESCRIPTIVE statistics, RESEARCH funding, MEDLINE, OBSESSIVE-compulsive disorder, EXERCISE therapy, GREY literature, EVALUATION
Abstract

This systematic review and meta-analysis assessed the efficacy of exercise in reducing OCD symptoms. We searched PubMed, Cochrane Central Register of Controlled Trials, MEDLINE, Scopus and grey literature until March 2022. The study was preregistered at Prospero (CRD42021283931). We included randomised controlled and pre-post trials assessing physical activity as an intervention for OCD. Risk of bias was assessed using the Cochrane ROBINS-I tool and the RoB2 tool. The analysis included 6 trials (N = 92); 2 were RCTS and 4 were pre-post design studies. A random-effects meta-analysis of pre-post data identified a large reduction of OCD symptoms following exercise (g = 1.33 [95%CI 1.06–1.61]; k = 6). Exercise was also associated with significant pre-post reductions in anxiety (g = 0.71 [95%CI 0.37–1.05; k = 4) and depression (g = 0.57 [95%CI 0.26–0.89]; k = 2). Risk of bias was moderate-high in uncontrolled trials on the ROBINS-I and RCTs showed 'some concerns' on the RoB2. Exercise was associated with a large pre-post reduction of OCD symptoms; however, few trials were of robust quality and all were at risk of bias. Further well-powered and better quality RCTs are required to assess the role of exercise as an intervention for OCD. Studies exploring exercise as an adjunct therapy for OCD have small participant numbers, therefore a systematic review and meta-analysis is needed to estimate potential efficacy. Pre-post analysis shows that exercise was associated with a large reduction of OCD symptoms The current systematic review and meta-analysis points to the potential for exercise to be beneficial for the treatment for OCD symptoms. However, more well-powered and better controlled RCTs are required to fully assess the benefit of exercise for the treatment of OCD symptoms. [ABSTRACT FROM AUTHOR]

Published
2023
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47. Effects of exercise on obsessive-compulsive disorder symptoms: a systematic review and meta-analysis

Author

Bottoms, Lindsay, primary, Prat Pons, Montserrat, additional, Fineberg, Naomi A., additional, Pellegrini, Luca, additional, Fox, Oliver, additional, Wellsted, David, additional, Drummond, Lynne M., additional, Reid, Jemma, additional, Baldwin, David S., additional, Hou, Ruihua, additional, Chamberlain, Samuel, additional, Sireau, Nick, additional, Grohmann, Dominique, additional, and Laws, Keith R., additional

Published
2022
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49. Adverse Reactions after the Third Dose of the BNT162b2 mRNA COVID-19 Vaccine among Medical School Residents in a Regional Reference University Hospital in Italy

Author

Rahmani, Alborz, primary, Dini, Guglielmo, additional, Montecucco, Alfredo, additional, Orsi, Andrea, additional, Sticchi, Laura, additional, Domnich, Alexander, additional, Bruzzone, Bianca, additional, Pellegrini, Luca, additional, Manca, Alessia, additional, Ogliastro, Matilde, additional, Kusznir Vitturi, Bruno, additional, Zacconi, Sonia, additional, Debarbieri, Nicoletta, additional, Icardi, Giancarlo, additional, and Durando, Paolo, additional

Published
2022
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