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1. Evaluation of Human Esophageal Epithelium Permeability in Presence of Different Formulations Containing Hyaluronic Acid and Chondroitin Sulphate

Author

Pellegatta G, Spadaccini M, Lamonaca L, Craviotto V, D'Amico F, Ceriotti L, Meloni M, and Repici A

Subjects
hyaluronic acid, chondroitin-sulphate, gastroesophageal reflux disease, antacid, caffeine, lucifer yellow, Medical technology, R855-855.5
Abstract

Gaia Pellegatta,1 Marco Spadaccini,1 Laura Lamonaca,1 Vincenzo Craviotto,1 Ferdinando D’Amico,1 Laura Ceriotti,2 Marisa Meloni,2 Alessandro Repici1 1Humanitas Clinical and Research Center and Humanitas University, Digestive Endoscopy Unit, Division of Gastroenterology, Rozzano, MI, Italy; 2VitroScreen, Milano, ItalyCorrespondence: Gaia PellegattaDigestive Endoscopy Unit, Division of Gastroenterology, Humanitas Research Hospital, Via Manzoni 56, Rozzano, MI 20089, ItalyTel +390282247091Email gaia.pellegatta@humanitas.itPurpose: New medical devices that contain hyaluronic acid (HA) and chondroitin sulphate (CS), with or without antacid components, have been developed for the treatment of gastroesophageal reflux disease (GERD) with the aim of improving oesophageal mucosal defences by creating a film on the oesophageal mucosa and acting as a mechanical barrier against the noxious components of refluxate, both acidic and basic.Methods: The film-forming and protective efficacy of medical device A based on HA and CS plus aluminium hydroxide, device B combining HA and CS with magnesium trisilicate and device C with only the combination of HA and CS was tested on a reconstructed human oesophageal epithelium (HO2E/S/5) as a biological model in 2 different pH environments, neutral and acidic, to mimic realistic conditions. Caffeine penetration kinetics and Lucifer yellow (LY) permeability modifications induced by these products were compared to those induced by a negative control series (saline solution, code NC) and positive control series (white Vaseline, code V) under neutral and acidic pH conditions.Results: Under neutral and acidic pH conditions, compared to the negative control, all the products tested reduced (> 80% and 85– 90%, respectively) the caffeine passage, and no significant difference was observed among the products tested. Under neutral and acidic conditions, the LY permeabilities registered with device A and device C were not different from that registered with the negative control, while an LY flux% increase was calculated after 2 hrs of treatment (21.1%) with device B under acidic conditions.Conclusion: These results confirm the ability of the products tested to interact with the oesophageal epithelium in order to adhere and create a stable protective film for at least 2 hours after their homogeneous distribution on the epithelium surface. Further clinical studies are needed to test these devices in the topical treatment of gastroesophageal reflux symptoms.Keywords: hyaluronic acid, chondroitin sulphate, gastroesophageal reflux disease, antacid, caffeine, Lucifer yellow

Published
2020

4. T.01.9: EVALUATION OF EFFICACY, SAFETYAND PATIENTS’ SATISFACTION OF THERAPEUTIC SWITCH FROM OFF-LABEL SWALLOWED TOPICAL CORTICOSTEROIDS TO BUDESONIDE ORODISPERSIBLE TABLETS IN PATIENTS WITH EOSINOPHILIC ESOPHAGITIS

Author

Pellegatta, G., primary, Mastrorocco, E., additional, Racca, F., additional, Giugliano, F., additional, Spadaccini, M., additional, Maselli, R., additional, Fugazza, A., additional, Hassan, C., additional, and Repici, A., additional

Published
2024
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6. Evaluation of Efficacy, Safety and Patients' Satisfaction of Therapeutic Switch from Off-Label Swallowed Topical Corticosteroids to Budesonide Orodispersible Tablets in patients with Eosinophilic Esophagitis

Author

Pellegatta, G., additional, Mastrorocco, E., additional, Racca, F., additional, Giugliano, F., additional, Spadaccini, M., additional, Maselli, R., additional, Fugazza, A., additional, Hassan, C., additional, and Repici, A., additional

Published
2024
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8. Impact of EUS-guided biliary drainage on the management of difficult biliary cannulation in patients with distal malignant biliary obstruction

Author

Spadaccini, M., additional, Giacchetto, M. C., additional, Colombo, M., additional, Andreozzi, M., additional, Carrara, S., additional, Alessandro, D. M., additional, franchellucci, G., additional, Terrin, M., additional, Binda, C., additional, Mauro, A., additional, Massimi, D., additional, Roberta, M., additional, Capogreco, A., additional, Galtieri, A., additional, Pellegatta, G., additional, Fabbri, C., additional, Anderloni, A., additional, Hassan, C., additional, Repici, A., additional, and Fugazza, A., additional

Published
2024
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9. Gender authorship in major US and European gastroenterology journals: the gap is still unfilled

Author

Mastrorocco, E., additional, Terrin, M., additional, Migliorisi, G., additional, Masoni, B., additional, Farinola, V., additional, De Deo, D., additional, Ferretti, S., additional, Poletti, V., additional, Mercurio, M., additional, Bartocci, B., additional, Galtieri, A., additional, Pellegatta, G., additional, Ferrara, E., additional, Carrara, S., additional, Sethi, A., additional, Siddiqui, U., additional, Repici, A., additional, and Maselli, R., additional

Published
2023
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11. Pattern of macrovascular invasion in hepatocellular carcinoma

Author

Guarino, M., Cucchetti, A., Pontillo, G., Farinati, F., Benevento, F., Rapaccini, G. L., Di Marco, M., Caturelli, E., Zoli, M., Rodolfo, S., Cabibbo, G., Marra, F., Mega, A., Gasbarrini, A., Svegliati-Baroni, G., Foschi, F. G., Missale, G., Masotto, A., Nardone, G., Raimondo, G., Azzaroli, F., Vidili, G., Oliveri, F., Trevisani, F., Giannini, E. G., Morisco, F., Biselli, M., Caraceni, P., Garuti, F., Gramenzi, A., Neri, A., Rampoldi, D., Santi, V., Forgione, A., Granito, A., Muratori, L., Piscaglia, F., Sansone, V., Tovoli, F., Dajti, E., Marasco, G., Ravaioli, F., Cappelli, A., Golfieri, R., Mosconi, C., Renzulli, M., Cela, E. M., Facciorusso, A., Pelizzaro, F., Imondi, A., Sartori, A., Penzo, B., Cacciato, V., Casagrande, E., Moscatelli, A., Pellegatta, G., Pieri, G., de Matthaeis, N., Allegrini, G., Lauria, V., Ghittoni, G., Pelecca, G., Chegai, F., Coratella, F., Ortenzi, M., Olivari, A., Inno, A., Marchetti, F., Busacca, A., Camma, C., Di Martino, V., Rizzo, G. E. M., Franze, M. S., Saitta, C., Sauchella, A., Bevilacqua, V., Borghi, A., Gardini, A. C., Conti, F., Berardinelli, D., Ercolani, G., Napoli, L., Campani, C., Di Bonaventura, C., Gitto, S., Coccoli, P., Malerba, A., Capasso, M., Fiorentino, A., Pignata, L., Cossiga, V., Romagnoli, V., Guarino M., Cucchetti A., Pontillo G., Farinati F., Benevento F., Rapaccini G.L., Di Marco M., Caturelli E., Zoli M., Rodolfo S., Cabibbo G., Marra F., Mega A., Gasbarrini A., Svegliati-Baroni G., Foschi F.G., Missale G., Masotto A., Nardone G., Raimondo G., Azzaroli F., Vidili G., Oliveri F., Trevisani F., Giannini E.G., Morisco F., Biselli M., Caraceni P., Garuti F., Gramenzi A., Neri A., Rampoldi D., Santi V., Forgione A., Granito A., Muratori L., Piscaglia F., Sansone V., Tovoli F., Dajti E., Marasco G., Ravaioli F., Cappelli A., Golfieri R., Mosconi C., Renzulli M., Cela E.M., Facciorusso A., Pelizzaro F., Imondi A., Sartori A., Penzo B., Cacciato V., Casagrande E., Moscatelli A., Pellegatta G., Pieri G., de Matthaeis N., Allegrini G., Lauria V., Ghittoni G., Pelecca G., Chegai F., Coratella F., Ortenzi M., Olivari A., Inno A., Marchetti F., Busacca A., Camma C., Di Martino V., Rizzo G.E.M., Franze M.S., Saitta C., Sauchella A., Bevilacqua V., Borghi A., Gardini A.C., Conti F., Berardinelli D., Ercolani G., Napoli L., Campani C., Di Bonaventura C., Gitto S., Coccoli P., Malerba A., Capasso M., Fiorentino A., Pignata L., Cossiga V., Romagnoli V., Guarino, M., Cucchetti, A., Pontillo, G., Farinati, F., Benevento, F., Rapaccini, G. L., Di Marco, M., Caturelli, E., Zoli, M., Rodolfo, S., Cabibbo, G., Marra, F., Mega, A., Gasbarrini, A., Svegliati-Baroni, G., Foschi, F. G., Missale, G., Masotto, A., Nardone, G., Raimondo, G., Azzaroli, F., Vidili, G., Oliveri, F., Trevisani, F., Giannini, E. G., Morisco, F., Biselli, M., Caraceni, P., Garuti, F., Gramenzi, A., Neri, A., Rampoldi, D., Santi, V., Forgione, A., Granito, A., Muratori, L., Piscaglia, F., Sansone, V., Tovoli, F., Dajti, E., Marasco, G., Ravaioli, F., Cappelli, A., Golfieri, R., Mosconi, C., Renzulli, M., Cela, E. M., Facciorusso, A., Pelizzaro, F., Imondi, A., Sartori, A., Penzo, B., Cacciato, V., Casagrande, E., Moscatelli, A., Pellegatta, G., Pieri, G., de Matthaeis, N., Allegrini, G., Lauria, V., Ghittoni, G., Pelecca, G., Chegai, F., Coratella, F., Ortenzi, M., Olivari, A., Inno, A., Marchetti, F., Busacca, A., Camma, C., Di Martino, V., Rizzo, G. E. M., Franze, M. S., Saitta, C., Sauchella, A., Bevilacqua, V., Borghi, A., Gardini, A. C., Conti, F., Berardinelli, D., Ercolani, G., Napoli, L., Campani, C., Di Bonaventura, C., Gitto, S., Coccoli, P., Malerba, A., Capasso, M., Fiorentino, A., Pignata, L., Cossiga, V., and Romagnoli, V.

Subjects
Ablation Techniques, Male, Registrie, Cirrhosis, Clinical Biochemistry, Mesenteric Vein, loco-regional treatment, 030204 cardiovascular system & hematology, Biochemistry, Gastroenterology, surgery, Antineoplastic Agent, Liver disease, 0302 clinical medicine, Non-alcoholic Fatty Liver Disease, cirrhosis, hepatocellular carcinoma, portal vein thrombosis, transplantation, Ascites, Ablation Technique, Registries, 030212 general & internal medicine, Chronic, Settore MED/12 - Gastroenterologia, Portal Vein, Liver Diseases, Liver Neoplasms, General Medicine, Middle Aged, Sorafenib, Prognosis, Hepatitis B, Alcoholic, Hepatitis C, Tumor Burden, Survival Rate, Italy, Liver Neoplasm, Hepatocellular carcinoma, Ascite, Female, medicine.symptom, Liver cancer, Human, medicine.medical_specialty, Carcinoma, Hepatocellular, Prognosi, Antineoplastic Agents, End Stage Liver Disease, 03 medical and health sciences, Mesenteric Veins, Hepatitis B, Chronic, Internal medicine, medicine, Humans, Hepatectomy, Neoplasm Invasiveness, portal vein thrombosi, Liver Diseases, Alcoholic, Aged, Neoplasm Invasivene, Performance status, business.industry, Carcinoma, Settore MED/09 - MEDICINA INTERNA, Patient Acuity, Hepatocellular, Hepatitis C, Chronic, medicine.disease, Liver Transplantation, Transplantation, Liver function, business, cirrhosi
Abstract

Background and aims: In patients with hepatocellular carcinoma (HCC), macrovascular invasion (MaVI) limits treatment options and decreases survival. Detailed data on the relationship between MaVI extension and patients' characteristics, and its impact on patients' outcome are limited. We evaluated the prevalence and extension of MaVI in a large cohort of consecutive HCC patients, analysing its association with liver disease and tumour characteristics, as well as with treatments performed and patients' survival. Methods: We analysed data of 4774 patients diagnosed with HCC recorded in the Italian Liver Cancer (ITA.LI.CA) database (2008-2018). Recursive partition analysis (RPA) was performed to evaluate interactions between MaVI, clinical variables and treatment, exploring the inter-relationship determining overall survival. Results: MaVI prevalence was 11.1%, and median survival of these patients was 6.0months (95% CI, 5.1-7.1). MaVI was associated with younger age at diagnosis, presence of symptoms, worse Performance Status (PS) and liver function, high alphafetoprotein levels and large HCCs. MaVI extension was associated with worse PS, ascites and greater impairment in liver function. RPA identified patients' categories with different treatment indications and survival, ranging from 2.4months in those with PS>1 and ascites, regardless of MaVI extension (receiving best supportive care in 90.3% of cases), to 14.1months in patients with PS 0-1, no ascites and Vp1-Vp2 MaVI (treated with surgery in 19.1% of cases). Conclusions: MaVI presence and extension, together with PS and ascites, significantly affect patients' survival and treatment selection. The decision tree based on these parameters may help assess patients' prognosis and inform therapeutic decisions.

Published
2021

12. Endoscopic ultrasound-guided ablation of solid pancreatic lesions: A systematic review of early outcomes with pooled analysis

Author

Spadaccini, M., Leo, M. Di, Iannone, A., Hoff, D.W. von den, Fugazza, A., Galtieri, P.A., Pellegatta, G., Maselli, R., Anderloni, A., Colombo, M., Siersema, P.D., Carrara, S., Repici, A., Spadaccini, M., Leo, M. Di, Iannone, A., Hoff, D.W. von den, Fugazza, A., Galtieri, P.A., Pellegatta, G., Maselli, R., Anderloni, A., Colombo, M., Siersema, P.D., Carrara, S., and Repici, A.

Abstract

Contains fulltext : 252157.pdf (Publisher’s version ) (Open Access), BACKGROUND: Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) is emerging as a complementary therapeutic approach for pancreatic solid masses. However, results of published data are difficult to interpret because of a retrospective design and small sample size. AIM: To systematically review data on EUS-RFA for solid lesions and to pool the results of the different experiences in order to provide more consistent evidence in terms of safety and efficacy. METHODS: A comprehensive systematic literature search on the main databases was performed to identify articles in which patients with pancreatic solid lesions underwent EUS-RFA. The primary outcomes were procedure-related adverse events (AEs) and mortality. Secondary outcomes were the technical success rate and the effects on primary tumor growth. Statistical analyses were performed using Stata version 14.0. RESULTS: In total, 14 studies were included, with 120 patients undergoing 153 ablations of 129 solid pancreatic lesions. The STARmed technology was used in seven studies, the Habib system in six studies, and the HybridTherm probe in one study. The pooled technical success rate was 99.0% (I (2): 25.82%). The pooled overall AE rate was 8.0% (I (2): 11.46%). Excluding mild AEs, the pooled rates of serious AEs was 1.0% (I (2): 0%). No mortality related to the procedure was reported. CONCLUSION: The present pooled analysis confirms the safety and feasibility of EUS-RFA.

Published
2022

13. Artificial intelligence and colonoscopy experience: Lessons from two randomised trials

Author

Repici, A., Spadaccini, M., Antonelli, G., Correale, L., Maselli, R., Galtieri, P. A., Pellegatta, G., Capogreco, A., Milluzzo, S. M., Lollo, G., Di Paolo, D., Badalamenti, M., Ferrara, E., Fugazza, A., Carrara, S., Anderloni, A., Rondonotti, E., Amato, A., De Gottardi, A., Spada, Cristiano, Radaelli, F., Savevski, V., Wallace, M. B., Sharma, P., Rosch, T., Hassan, Cesare, Spada C. (ORCID:0000-0002-5692-0960), Hassan C., Repici, A., Spadaccini, M., Antonelli, G., Correale, L., Maselli, R., Galtieri, P. A., Pellegatta, G., Capogreco, A., Milluzzo, S. M., Lollo, G., Di Paolo, D., Badalamenti, M., Ferrara, E., Fugazza, A., Carrara, S., Anderloni, A., Rondonotti, E., Amato, A., De Gottardi, A., Spada, Cristiano, Radaelli, F., Savevski, V., Wallace, M. B., Sharma, P., Rosch, T., Hassan, Cesare, Spada C. (ORCID:0000-0002-5692-0960), and Hassan C.

Abstract

Background and aims Artificial intelligence has been shown to increase adenoma detection rate (ADR) as the main surrogate outcome parameter of colonoscopy quality. To which extent this effect may be related to physician experience is not known. We performed a randomised trial with colonoscopists in their qualification period (AID-2) and compared these data with a previously published randomised trial in expert endoscopists (AID-1). Methods In this prospective, randomised controlled non-inferiority trial (AID-2), 10 non-expert endoscopists (<2000 colonoscopies) performed screening/surveillance/diagnostic colonoscopies in consecutive 40-80 year-old subjects using high-definition colonoscopy with or without a real-time deep-learning computer-aided detection (CADe) (GI Genius, Medtronic). The primary outcome was ADR in both groups with histology of resected lesions as reference. In a post-hoc analysis, data from this randomised controlled trial (RCT) were compared with data from the previous AID-1 RCT involving six experienced endoscopists in an otherwise similar setting. Results In 660 patients (62.3±10 years; men/women: 330/330) with equal distribution of study parameters, overall ADR was higher in the CADe than in the control group (53.3% vs 44.5%; relative risk (RR): 1.22; 95% CI: 1.04 to 1.40; p<0.01 for non-inferiority and p=0.02 for superiority). Similar increases were seen in adenoma numbers per colonoscopy and in small and distal lesions. No differences were observed with regards to detection of non-neoplastic lesions. When pooling these data with those from the AID-1 study, use of CADe (RR 1.29; 95% CI: 1.16 to 1.42) and colonoscopy indication, but not the level of examiner experience (RR 1.02; 95% CI: 0.89 to 1.16) were associated with ADR differences in a multivariate analysis. Conclusions In less experienced examiners, CADe assistance during colonoscopy increased ADR and a number of related polyp parameters as compared with the control group. Experien

Published
2022

14. OC.05.3 PERFORMANCE OF AI-AIDED COLONOSCOPY FOR THE DETECTION OF HIGH-RISK COLORECTAL CANCER PRECURSORS: A SYSTEMATIC REVIEW AND META-ANALYSIS

Author

Spadaccini, M., primary, Hassan, C., additional, Mori, Y., additional, Facciorusso, A., additional, Maselli, R., additional, Khalaf, K., additional, Alfarone, L., additional, Colombo, M., additional, Capogreco, A., additional, Galtieri, P.A., additional, Pellegatta, G., additional, Carrara, S., additional, Fugazza, A., additional, Anderloni, A., additional, Sharma, P., additional, and Repici, A., additional

Published
2022
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15. T.03.2 MULTICENTER STUDY OF COLD VERSUS HOT EMR FOR LARGE DUODENAL ADENOMAS

Author

Capogreco, A., primary, Spadaccini, M., additional, Maselli, R., additional, Galtieri, P.A., additional, Pellegatta, G., additional, Fugazza, A., additional, Anderloni, A., additional, Ferrara, E.C., additional, Carrara, S., additional, Vespa, E., additional, Pugliese, N., additional, Parigi, T., additional, Schachschal, G., additional, Creutzfeldt, A., additional, Hassan, C., additional, Bhandari, P., additional, Meining, A., additional, Rösch, T., additional, and Repici, A., additional

Published
2022
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16. OC.05.6 COMPARING NUMBER AND RELEVANCE OF FALSE ACTIVATIONS BETWEEN TWO ARTIFICIAL INTELLIGENCE CADE SYSTEMS: THE NOISE STUDY

Author

Spadaccini, M., primary, Hassan, C., additional, Alfarone, L., additional, Da Rio, L., additional, Maselli, R., additional, Carrara, S., additional, Galtieri, P.A., additional, Pellegatta, G., additional, Fugazza, A., additional, Koleth, G., additional, Emmanuel, J., additional, Anderloni, A., additional, Mori, Y., additional, Wallace, M.B., additional, Sharma, P., additional, and Repici, A., additional

Published
2022
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18. OC.04.3 CHARACTERIZATION COMPARISON BETWEEN TWO CAD SYSTEMS (COMBO CAD STUDY) IN REAL-LIFE ENDOSCOPY: AN INTERIM ANALYSIS

Author

Hassan, C., primary, Spadaccini, M., additional, Alfarone, L., additional, Da Rio, L., additional, Solitano, V., additional, Ferretti, S., additional, Poletti, V., additional, Maselli, R., additional, Carrara, S., additional, Galtieri, P.A., additional, Pellegatta, G., additional, Fugazza, A., additional, Anderloni, A., additional, Ferrara, E.C., additional, Spaggiari, P., additional, Terracciano, L.M., additional, and Repici, A., additional

Published
2022
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19. COMPARING NUMBER AND RELEVANCE OF FALSE ACTIVATIONS BETWEEN TWO ARTIFICIAL INTELLIGENCE CADE SYSTEMS: THE NOISE STUDY

Author

Spadaccini, M., additional, Alfarone, L., additional, Da Rio, L., additional, Maselli, R., additional, Carrara, S., additional, Galtieri, P.A., additional, Pellegatta, G., additional, Fugazza, A., additional, Koleth, G., additional, Emmanuel, J., additional, Anderloni, A., additional, Mori, Y., additional, Wallace, M.B, additional, Sharma, P., additional, Repici, A., additional, and Hassan, C., additional

Published
2022
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20. TECHNICAL OUTCOMES AND RISK OF STRICTURE AFTER ENDOSCOPIC SUBMUCOSAL DISSECTION FOR LARGE COLORECTAL LESIONS

Author

Maselli, R., additional, Spadaccini, M., additional, Galtieri, P.A., additional, Albouys, J., additional, Legros, R., additional, Lambin, T., additional, Capogreco, A., additional, Pellegatta, G., additional, Ferrara, E.C., additional, Fugazza, A., additional, Carrara, S., additional, Anderloni, A., additional, Pioche, M., additional, Jaques, J., additional, and Repici, A., additional

Published
2022
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21. LONG-TERM EFFICACY AND GASTROESOPHAGEAL REFLUX DISEASE AFTER PER ORAL ENDOSCOPIC MYOTOMY (POEM): A PROSPECTIVE STUDY WITH 5-YEARS OBJECTIVE FOLLOW-UP

Author

Vespa, E., additional, Maselli, R., additional, Pellegatta, G., additional, Galtieri, P.A., additional, Carlani, E., additional, Capogreco, A., additional, Spadaccini, M., additional, Nicoletti, R., additional, Craviotto, V., additional, Omodei, P., additional, Anderloni, A., additional, Fugazza, A., additional, Carrara, S., additional, Ferrara, E.C., additional, Hassan, C., additional, and Repici, A., additional

Published
2022
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22. MULTICENTER STUDY OF COLD VERSUS HOT EMR FOR LARGE DUODENAL ADENOMAS

Author

Capogreco, A., additional, Spadaccini, M., additional, Maselli, R., additional, Hassan, C., additional, Galtieri, P.A., additional, Pellegatta, G., additional, Anderloni, A., additional, Fugazza, A., additional, Carrara, S., additional, Ferrara, E.C., additional, Colombo, M., additional, Vespa, E., additional, Pugliese, N., additional, Parigi, T., additional, Schachschal, G., additional, Creutzfeldt, A., additional, Bhandari, P., additional, Meining, A., additional, Rosch, T., additional, and Repici, A., additional

Published
2022
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23. DETECTION RATE OF SESSILE SERRATED LESIONS AND ACCURACY OF OPTICAL BIOPSY AS QUALITY INDICATORS

Author

Gubbiotti, A., additional, Spadaccini, M., additional, Maselli, R., additional, Anderloni, A., additional, Carrara, S., additional, Galtieri, A., additional, Ferrara, E.C., additional, Pellegatta, G., additional, Fugazza, A., additional, Alfarone, L., additional, Da Rio, L., additional, Migliorisi, G., additional, Masoni, B., additional, Brandaleone, L., additional, Bertoli, P., additional, Poletti, V., additional, Ferretti, S., additional, Polverini, D., additional, Marcozzi, G., additional, Terrin, M., additional, Mastrorocco, E., additional, Franchellucci, G., additional, Hassan, C., additional, and Repici, A., additional

Published
2022
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24. CHARACTERIZATION COMPARISON BETWEEN TWO CAD SYSTEMS (COMBO CAD STUDY) IN REAL-LIFE ENDOSCOPY: AN INTERIM ANALYSIS

Author

Hassan, C., additional, Spadaccini, M., additional, Alfarone, L., additional, Da Rio, L., additional, Solitano, V., additional, Ferretti, S., additional, Poletti, V., additional, Maselli, R., additional, Carrara, S., additional, Galtieri, P.A., additional, Pellegatta, G., additional, Fugazza, A., additional, Anderloni, A., additional, Terracciano, L.M., additional, Spaggiari, P., additional, and Repici, A., additional

Published
2022
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27. OC.02.4 TECHNICAL OUTCOMES AND RISK OF STRICTURE AFTER ENDOSCOPIC SUBMUCOSAL DISSECTION FOR LARGE COLORECTAL LESIONS

Author

Maselli, R., primary, Spadaccini, M., additional, Galtieri, P.A., additional, Albouys, J., additional, Legros, R., additional, Capogreco, A., additional, Pellegatta, G., additional, Ferrara, E.C., additional, Fugazza, A., additional, Carrara, S., additional, Anderloni, A., additional, Jaques, J., additional, and Repici, A., additional

Published
2021
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28. AF.16 DIAGNOSTIC DELAY AND MISDIAGNOSIS IN EOSINOPHILIC ESOPHAGITIS

Author

Lenti, M.V., primary, Savarino, E., additional, Mauro, A., additional, Penagini, R., additional, Racca, F., additional, Ghisa, M., additional, Laserra, G., additional, Arsiè, E., additional, Longoni, V., additional, De Bortoli, N., additional, Sostilio, A., additional, Marabotto, E., additional, Ziola, S., additional, Vanoli, A., additional, Zingone, F., additional, Barberio, B., additional, Tolone, S., additional, Docimo, L., additional, Pellegatta, G., additional, Paoletti, G., additional, Ribolsi, M., additional, Repici, A., additional, Klersy, C., additional, and Di Sabatino, A., additional

Published
2021
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29. OC.03.5 FEASIBILITY AND SAFETY OF A NEW DEDICATED BILIARY STENT FOR TRANSMURAL EUS-GUIDED HEPATICO-GASTROSTOMY: THE FIT STUDY

Author

Fugazza, A., primary, Spadaccini, M., additional, Colombo, M., additional, Carrara, S., additional, Maselli, R., additional, Galtieri, P.A., additional, Pellegatta, G., additional, Ferrara, E.C., additional, Preatoni, P., additional, Omodei, P.D., additional, Ayoubi, M., additional, Repici, A., additional, and Anderloni, A., additional

Published
2021
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30. AF.122 SHORT- AND LONG-TERM OUTCOMES OF WESTERN-BASED ENDOSCOPIC SUBMUCOSAL DISSECTION FOR COLORECTAL LESIONS

Author

Maselli, R., primary, Spadaccini, M., additional, Belletrutti, P.J., additional, Galtieri, P.A., additional, Attardo, S., additional, Capogreco, A., additional, Carrara, S., additional, Anderloni, A., additional, Fugazza, A., additional, Ferrara, E.C., additional, Pellegatta, G., additional, Iannone, A., additional, Hassan, C., additional, and Repici, A., additional

Published
2021
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32. OC.02.6 ARTIFICIAL INTELLIGENCE VERSUS ADVANCED IMAGING FOR DETECTION OF COLORECTAL NEOPLASIA: A NETWORK METAANALYSIS

Author

Spadaccini, M., primary, Iannone, A., additional, Maselli, R., additional, Badalamenti, M., additional, Desai, M., additional, Thoguluva Chandrasekar, V., additional, Patel, H.K., additional, Fugazza, A., additional, Pellegatta, G., additional, Galtieri, P.A., additional, Carrara, S., additional, Anderloni, A., additional, Rex, D.K., additional, Victor, S., additional, Wallace, M.B., additional, Bhandari, P., additional, Sharma, P., additional, Hassan, C., additional, and Repici, A., additional

Published
2021
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33. AF.116 SUBMUCOSAL TUNNELLING TECHNIQUES FOR ZENKER’S DIVERTICULUM: A SYSTEMATIC REVIEW OF EARLY OUTCOMES WITH POOLED ANALYSIS

Author

Spadaccini, M., primary, Maselli, R., additional, Thoguluva Chandrasekar, V., additional, Patel, H.K., additional, Fugazza, A., additional, Galtieri, P.A., additional, Pellegatta, G., additional, Attardo, S., additional, Carrara, S., additional, Anderloni, A., additional, Desai, P., additional, Sharma, P., additional, Khashab, M., additional, and Repici, A., additional

Published
2021
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35. Novel 1-L polyethylene glycol + ascorbate versus high-volume polyethylene glycol regimen for colonoscopy cleansing: a multicenter, randomized, phase IV study

Author

Repici, A., Spada, Cristiano, Cannizzaro, Rino, Traina, M., Maselli, R., Maiero, S., Galtieri, A., Guarnieri, Giorgia, Di Leo, Mauro, Lorenzetti, R., Capogreco, A., Spadaccini, M., Antonelli, G., Zullo, A., Amata, M., Ferrara, Paola Emilia, Correale, L., Granata, A., Cesaro, Paola, Radaelli, F., Minelli Grazioli, L., Anderloni, A., Fugazza, A., Finati, E., Pellegatta, G., Carrara, S., Occhipinti, P., Buda, Alessandro, Fuccio, L., Manno, M., Hassan, Cesare, Spada C. (ORCID:0000-0002-5692-0960), Cannizzaro R., Guarnieri G., Di Leo M., Ferrara E., Cesaro P., Buda A., Hassan C., Repici, A., Spada, Cristiano, Cannizzaro, Rino, Traina, M., Maselli, R., Maiero, S., Galtieri, A., Guarnieri, Giorgia, Di Leo, Mauro, Lorenzetti, R., Capogreco, A., Spadaccini, M., Antonelli, G., Zullo, A., Amata, M., Ferrara, Paola Emilia, Correale, L., Granata, A., Cesaro, Paola, Radaelli, F., Minelli Grazioli, L., Anderloni, A., Fugazza, A., Finati, E., Pellegatta, G., Carrara, S., Occhipinti, P., Buda, Alessandro, Fuccio, L., Manno, M., Hassan, Cesare, Spada C. (ORCID:0000-0002-5692-0960), Cannizzaro R., Guarnieri G., Di Leo M., Ferrara E., Cesaro P., Buda A., and Hassan C.

Abstract

Background and Aims: Adequate bowel cleansing is critical to ensure quality and safety of a colonoscopy. A novel 1-L polyethylene glycol plus ascorbate (1L-PEG+ASC) regimen was previously validated against low-volume regimens but was never compared with high-volume regimens. Methods: In a phase IV study, patients undergoing colonoscopy were randomized 1:1 to receive split-dose 1L PEG+ASC or a split-dose 4-L PEG-based regimen (4L-PEG) in 5 Italian centers. Preparation was assessed with the Boston Bowel Preparation Scale (BBPS) by local endoscopists and centralized reading, both blinded to the randomization arm. The primary endpoint was noninferiority of 1L-PEG+ASC in colon cleansing. Secondary endpoints were superiority of 1L-PEG+ASC, patient compliance, segmental colon cleansing, adenoma detection rate, tolerability, and safety. Results: Three hundred eighty-eight patients (median age, 59.8 years) were randomized between January 2019 and October 2019: 195 to 1L-PEG+ASC and 193 to 4L-PEG. Noninferiority of 1L-PEG+ASC was demonstrated for cleansing in both the entire colon (BBPS ≥ 6: 97.9% vs 93%; relative risk [RR], 1.03; 95% confidence interval [CI], 1.001-1.04; P superiority = .027) and in the right-sided colon segment (98.4% vs 96.0%; RR, 1.02; 95% CI, .99-1.02; P noninferiority = .013). Compliance was higher with 1L-PEG+ASC than with 4L-PEG (178/192 [92.7%] vs 154/190 patients [81.1%]; RR, 1.10; 95% CI, 1.05-1.12), whereas no difference was found regarding safety (moderate/severe side effects: 20.8% vs 25.8%; P = .253). No difference in adenoma detection rate (38.8% vs 43.0%) was found. Conclusions: One-liter PEG+ASC showed noninferiority compared with 4L-PEG in achieving adequate colon cleansing and provided a higher patient compliance. No differences in tolerability and safety were detected. (Clinical trial registration number: NCT03742232.)

Published
2021

36. Pattern of macrovascular invasion in hepatocellular carcinoma

Author

Guarino, Mariateresa, Cucchetti, A., Pontillo, G., Farinati, F., Benevento, F., Rapaccini, Gian Ludovico, Di Marco, Maria Teresa, Caturelli, E., Zoli, M., Rodolfo, S., Cabibbo, G., Marra, F., Mega, A., Gasbarrini, Antonio, Svegliati-Baroni, G., Foschi, F. G., Missale, G., Masotto, A., Nardone, G., Raimondo, G., Azzaroli, F., Vidili, G., Oliveri, F., Trevisani, F., Giannini, E. G., Morisco, F., Biselli, M., Caraceni, P., Garuti, F., Gramenzi, A., Neri, A., Rampoldi, D., Santi, V., Forgione, Alessandra, Granito, A., Muratori, L., Piscaglia, F., Sansone, V., Tovoli, F., Dajti, E., Marasco, G., Ravaioli, F., Cappelli, A., Golfieri, R., Mosconi, C., Renzulli, M., Cela, E. M., Facciorusso, A., Pelizzaro, F., Imondi, A., Sartori, A., Penzo, B., Cacciato, V., Casagrande, E., Moscatelli, A., Pellegatta, G., Pieri, G., De Matthaeis, Nicoletta, Allegrini, G., Lauria, V., Ghittoni, G., Pelecca, G., Chegai, F., Coratella, F., Ortenzi, M., Olivari, Elena Armida, Inno, A., Marchetti, F., Busacca, A., Camma, C., Di Martino, V., Rizzo, G. E. M., Franze, M. S., Saitta, C., Sauchella, A., Bevilacqua, V., Borghi, A., Gardini, A. C., Conti, Francesco, Berardinelli, D., Ercolani, G., Napoli, L., Campani, C., Di Bonaventura, C., Gitto, S., Coccoli, P., Malerba, A., Capasso, Monica, Fiorentino, Alice, Pignata, L., Cossiga, V., Romagnoli, V., Guarino M., Rapaccini G. L. (ORCID:0000-0002-6467-857X), Di Marco M., Gasbarrini A. (ORCID:0000-0002-7278-4823), Forgione A., de Matthaeis N., Olivari A., Conti F., Capasso M., Fiorentino A., Guarino, Mariateresa, Cucchetti, A., Pontillo, G., Farinati, F., Benevento, F., Rapaccini, Gian Ludovico, Di Marco, Maria Teresa, Caturelli, E., Zoli, M., Rodolfo, S., Cabibbo, G., Marra, F., Mega, A., Gasbarrini, Antonio, Svegliati-Baroni, G., Foschi, F. G., Missale, G., Masotto, A., Nardone, G., Raimondo, G., Azzaroli, F., Vidili, G., Oliveri, F., Trevisani, F., Giannini, E. G., Morisco, F., Biselli, M., Caraceni, P., Garuti, F., Gramenzi, A., Neri, A., Rampoldi, D., Santi, V., Forgione, Alessandra, Granito, A., Muratori, L., Piscaglia, F., Sansone, V., Tovoli, F., Dajti, E., Marasco, G., Ravaioli, F., Cappelli, A., Golfieri, R., Mosconi, C., Renzulli, M., Cela, E. M., Facciorusso, A., Pelizzaro, F., Imondi, A., Sartori, A., Penzo, B., Cacciato, V., Casagrande, E., Moscatelli, A., Pellegatta, G., Pieri, G., De Matthaeis, Nicoletta, Allegrini, G., Lauria, V., Ghittoni, G., Pelecca, G., Chegai, F., Coratella, F., Ortenzi, M., Olivari, Elena Armida, Inno, A., Marchetti, F., Busacca, A., Camma, C., Di Martino, V., Rizzo, G. E. M., Franze, M. S., Saitta, C., Sauchella, A., Bevilacqua, V., Borghi, A., Gardini, A. C., Conti, Francesco, Berardinelli, D., Ercolani, G., Napoli, L., Campani, C., Di Bonaventura, C., Gitto, S., Coccoli, P., Malerba, A., Capasso, Monica, Fiorentino, Alice, Pignata, L., Cossiga, V., Romagnoli, V., Guarino M., Rapaccini G. L. (ORCID:0000-0002-6467-857X), Di Marco M., Gasbarrini A. (ORCID:0000-0002-7278-4823), Forgione A., de Matthaeis N., Olivari A., Conti F., Capasso M., and Fiorentino A.

Abstract

Background and aims: In patients with hepatocellular carcinoma (HCC), macrovascular invasion (MaVI) limits treatment options and decreases survival. Detailed data on the relationship between MaVI extension and patients' characteristics, and its impact on patients' outcome are limited. We evaluated the prevalence and extension of MaVI in a large cohort of consecutive HCC patients, analysing its association with liver disease and tumour characteristics, as well as with treatments performed and patients' survival. Methods: We analysed data of 4774 patients diagnosed with HCC recorded in the Italian Liver Cancer (ITA.LI.CA) database (2008-2018). Recursive partition analysis (RPA) was performed to evaluate interactions between MaVI, clinical variables and treatment, exploring the inter-relationship determining overall survival. Results: MaVI prevalence was 11.1%, and median survival of these patients was 6.0 months (95% CI, 5.1-7.1). MaVI was associated with younger age at diagnosis, presence of symptoms, worse Performance Status (PS) and liver function, high alphafetoprotein levels and large HCCs. MaVI extension was associated with worse PS, ascites and greater impairment in liver function. RPA identified patients' categories with different treatment indications and survival, ranging from 2.4 months in those with PS > 1 and ascites, regardless of MaVI extension (receiving best supportive care in 90.3% of cases), to 14.1 months in patients with PS 0-1, no ascites and Vp1-Vp2 MaVI (treated with surgery in 19.1% of cases). Conclusions: MaVI presence and extension, together with PS and ascites, significantly affect patients' survival and treatment selection. The decision tree based on these parameters may help assess patients' prognosis and inform therapeutic decisions.

Published
2021

37. The changing scenario of hepatocellular carcinoma in Italy: an update

Author

Garuti, F., Neri, A., Avanzato, F., Gramenzi, A., Rampoldi, D., Rucci, P., Farinati, F., Giannini, E. G., Piscaglia, F., Rapaccini, Gian Ludovico, Di Marco, Maria Teresa, Caturelli, E., Zoli, M., Sacco, R., Cabibbo, G., Marra, F., Mega, A., Morisco, F., Gasbarrini, Antonio, Svegliati-Baroni, G., Foschi, F. G., Missale, G., Masotto, A., Nardone, G., Raimondo, G., Azzaroli, F., Vidili, G., Brunetto, M. R., Trevisani, F., Biselli, M., Caraceni, P., Santi, V., Granito, A., Muratori, L., Sansone, V., Tovoli, F., Dajti, E., Marasco, G., Ravaioli, F., Cappelli, A., Golfieri, R., Mosconi, C., Renzulli, M., Cela, E. M., Facciorusso, A., Cacciato, V., Casagrande, E., Moscatelli, A., Pellegatta, G., De Matthaeis, Nicoletta, Allegrini, G., Lauria, V., Ghittoni, G., Pelecca, G., Chegai, F., Coratella, F., Ortenzi, M., Biasini, E., Olivani, A., Inno, A., Marchetti, F., Busacca, A., Camma, C., Di Martino, V., Rizzo, G. E. M., Franze, M. S., Saitta, C., Sauchella, A., Bevilacqua, V., Berardinelli, D., Borghi, A., Gardini, A. C., Conti, Francesco, Cucchetti, A., Dall'Aglio, A. C., Ercolani, G., Campani, C., Di Bonaventura, C., Gitto, S., Malerba, P. C. A., Capasso, Monica, Guarino, Mariateresa, Oliveri, F., Romagnoli, V., Rapaccini G. L. (ORCID:0000-0002-6467-857X), Di Marco M., Gasbarrini A. (ORCID:0000-0002-7278-4823), de Matthaeis N., Conti F., Capasso M., Guarino M., Garuti, F., Neri, A., Avanzato, F., Gramenzi, A., Rampoldi, D., Rucci, P., Farinati, F., Giannini, E. G., Piscaglia, F., Rapaccini, Gian Ludovico, Di Marco, Maria Teresa, Caturelli, E., Zoli, M., Sacco, R., Cabibbo, G., Marra, F., Mega, A., Morisco, F., Gasbarrini, Antonio, Svegliati-Baroni, G., Foschi, F. G., Missale, G., Masotto, A., Nardone, G., Raimondo, G., Azzaroli, F., Vidili, G., Brunetto, M. R., Trevisani, F., Biselli, M., Caraceni, P., Santi, V., Granito, A., Muratori, L., Sansone, V., Tovoli, F., Dajti, E., Marasco, G., Ravaioli, F., Cappelli, A., Golfieri, R., Mosconi, C., Renzulli, M., Cela, E. M., Facciorusso, A., Cacciato, V., Casagrande, E., Moscatelli, A., Pellegatta, G., De Matthaeis, Nicoletta, Allegrini, G., Lauria, V., Ghittoni, G., Pelecca, G., Chegai, F., Coratella, F., Ortenzi, M., Biasini, E., Olivani, A., Inno, A., Marchetti, F., Busacca, A., Camma, C., Di Martino, V., Rizzo, G. E. M., Franze, M. S., Saitta, C., Sauchella, A., Bevilacqua, V., Berardinelli, D., Borghi, A., Gardini, A. C., Conti, Francesco, Cucchetti, A., Dall'Aglio, A. C., Ercolani, G., Campani, C., Di Bonaventura, C., Gitto, S., Malerba, P. C. A., Capasso, Monica, Guarino, Mariateresa, Oliveri, F., Romagnoli, V., Rapaccini G. L. (ORCID:0000-0002-6467-857X), Di Marco M., Gasbarrini A. (ORCID:0000-0002-7278-4823), de Matthaeis N., Conti F., Capasso M., and Guarino M.

Abstract

Background and aims: Epidemiology of hepatocellular carcinoma (HCC) is changing in most areas of the world. This study aimed at updating the changing scenario of aetiology, clinical presentation, management and prognosis of HCC in Italy during the last 15 years. Methods: Retrospective analysis of the Italian Liver Cancer (ITA.LI.CA) database included 6034 HCC patients managed in 23 centres from 2004 to 2018. Patients were divided into three groups according to the date of cancer diagnosis (2004-2008, 2009-2013 and 2014-2018). Results: The main results were: (i) a progressive patient ageing; (ii) a progressive increase of non-viral cases and, particularly, of ‘metabolic’ and ‘metabolic + alcohol’ HCCs; (iii) a slightly decline of cases diagnosed under surveillance, but with an incremental use of the semiannual schedule; (iv) a favourable cancer stage migration; (v) an increased use of radiofrequency ablation to the detriment of percutaneous ethanol injection; (vi) improved outcomes of ablative and transarterial treatments; (vii) an improved overall survival (adjusted for the lead time in surveyed patients) in the last calendar period, particularly in viral patients; (viii) a large gap between the number of potential candidates (according to oncologic criteria and age) to liver transplant and that of transplanted patients. Conclusions: During the last 15 years several aspects of HCC scenario have changed, as well as its management. The improvement in patient survival observed in the last period was likely because of a larger use of thermal ablation with respect to the less effective alcohol injection and to an improved management of intermediate stage patients.

Published
2021

40. Submucosal Tunnelling Techniques for Zenker’S Diverticulum: A Systematic Review of Early Outcomes With Pooled Analysis

Author

Spadaccini, M, additional, Maselli, R, additional, Thoguluva Chandrasekar, V, additional, Patel, HK, additional, Fugazza, A, additional, Galtieri, PA, additional, Pellegatta, G, additional, Attardo, S, additional, Carrara, S, additional, Anderloni, A, additional, Alkandari, A, additional, Sharma, P, additional, Khashab, M, additional, and Repici, A, additional

Published
2021
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43. Efficacy of Real-Time Computer-Aided Detection of Colorectal Neoplasia in a Non-Expert Setting: A Randomized Controlled Trial

Author

Repici, A, additional, Spadaccini, M, additional, Antonelli, G, additional, Maselli, R, additional, Galtieri, PA, additional, Pellegatta, G, additional, Capogreco, A, additional, Milluzzo, SM, additional, Lollo, G, additional, Ferrara, EC, additional, Fugazza, A, additional, Carrara, S, additional, Anderloni, A, additional, Amato, A, additional, De Gottardi, A, additional, Spada, C, additional, Radaelli, F, additional, and Hassan, C, additional

Published
2021
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44. Review article – esophageal reflux hypersensitivity: Non-GERD or still GERD?

Author

Savarino, V., Marabotto, E., Zentilin, P., Demarzo, M. G., Pellegatta, G., Frazzoni, M., De Bortoli, N., Tolone, S., Giannini, E. G., Savarino, E., Savarino, Vincenzo, Marabotto, Elisa, Zentilin, Patrizia, Demarzo, Maria Giulia, Pellegatta, Gaia, Frazzoni, Marzio, De Bortoli, Nicola, Tolone, Salvatore, Giannini, Edoardo Giovanni, and Savarino, Edoardo

Subjects
Functional heartburn, Gastro-esophageal reflux disease, Non-erosive reflux disease, Reflux hypersensitivity, Rome IV, digestive, oral, and skin physiology, humanities, digestive system diseases
Abstract

The most recent iteration of the classifications for functional esophageal disorders, Rome IV, proposed relevant modifications of the previous definitions for Rome III. They specifically considered increased esophageal acid exposure as the marker of gastroesophageal reflux disease (GERD), including the remaining part of non-erosive reflux disease patients with normal acid in the group with functional alterations, considering both reflux hypersensitivity and functional heartburn. However, recent pathophysiological and therapeutic data suggest the need for a return to including reflux hypersensitivity in the GERD spectrum. Indeed, physiologic alterations in esophageal mucosal integrity and chemical clearance, the presence of microscopic esophagitis, and strict symptom-reflux association support the concept that reflux hypersensitivity pertains to GERD. Surgical anti-reflux therapy has resulted in positive outcomes, even in the long term, in patients with reflux hypersensitivity and not in those with functional heartburn. Moreover, clinical trials using neuromodulators have been scarce and provided conflicting results. As a result, the real progress of the Rome IV classifications is in dispute. This article aims to summarize the most recent knowledge of non-erosive reflux disease and reflux hypersensitivity to discuss the utility of Rome IV criteria in the identification and management of functional esophageal disorders.

Published
2020

45. Endoscopy units and the COVID-19 Outbreak: A Multi-Center Experience from Italy

Author

Repici, A, Pace, F, Gabbiadini, R, Colombo, M, Hassan, C, Dinelli, M, Maselli, R, Spadaccini, M, Mutignani, M, Gabbrielli, A, Signorelli, C, Spada, C, Leoni, P, Fabbri, C, Segato, S, Gaffuri, N, Mangiavillano, B, Radaelli, F, Salerno, R, Bargiggia, S, Maroni, L, Benedetti, A, Occhipinti, P, De Grazia, F, Ferraris, L, Cengia, G, Greco, S, Alvisi, C, Scarcelli, A, De Luca, L, Cereatti, F, Testoni, Pa, Mingotto, R, Aragona, G, Manes, G, Beretta, P, Amvrosiadis, G, Cennamo, V, Lella, F, Missale, G, Lagoussis, P, Triossi, O, Giovanardi, M, De Roberto, G, Canto, P, Buscarini, E, Anderloni, A, Carrara, S, Fugazza, A, Galtieri, Pa, Pellegatta, G, Antonelli, G, Rosch, T, and Sharma, P

Subjects
Coronavirus, Pandemic, Survery, COVID-19, Endoscopy
Published
2020

46. Endoscopy Units and the Coronavirus Disease 2019 Outbreak: A Multicenter Experience From Italy

Author

Repici, A., Pace, F., Gabbiadini, R., Colombo, M., Hassan, Cesare, Dinelli, M., Maselli, R., Spadaccini, M., Mutignani, Massimiliano, Gabbrielli, A., Signorelli, C., Spada, Cristiano, Leoni, Paola, Fabbri, Carlo, Segato, S., Gaffuri, N., Mangiavillano, B., Radaelli, F., Salerno, R., Bargiggia, S., Maroni, L., Benedetti, A., Occhipinti, P., De Grazia, F., Ferraris, L., Cengia, G., Greco, Sara, Alvisi, C., Scarcelli, A., De Luca, L., Cereatti, F., Testoni, P. A., Mingotto, R., Aragona, G., Manes, G., Beretta, P., Amvrosiadis, G., Cennamo, Vincenzo, Lella, F., Missale, G., Lagoussis, P., Triossi, O., Giovanardi, Mattia, De Roberto, G., Cantu, P., Buscarini, E., Anderloni, A., Carrara, S., Fugazza, A., Galtieri, P. A., Pellegatta, G., Antonelli, G., Rosch, T., Sharma, P., Hassan C., Mutignani M. (ORCID:0000-0002-1272-4888), Spada C. (ORCID:0000-0002-5692-0960), Leoni P., Fabbri C., Greco S., Cennamo V., Giovanardi M., Repici, A., Pace, F., Gabbiadini, R., Colombo, M., Hassan, Cesare, Dinelli, M., Maselli, R., Spadaccini, M., Mutignani, Massimiliano, Gabbrielli, A., Signorelli, C., Spada, Cristiano, Leoni, Paola, Fabbri, Carlo, Segato, S., Gaffuri, N., Mangiavillano, B., Radaelli, F., Salerno, R., Bargiggia, S., Maroni, L., Benedetti, A., Occhipinti, P., De Grazia, F., Ferraris, L., Cengia, G., Greco, Sara, Alvisi, C., Scarcelli, A., De Luca, L., Cereatti, F., Testoni, P. A., Mingotto, R., Aragona, G., Manes, G., Beretta, P., Amvrosiadis, G., Cennamo, Vincenzo, Lella, F., Missale, G., Lagoussis, P., Triossi, O., Giovanardi, Mattia, De Roberto, G., Cantu, P., Buscarini, E., Anderloni, A., Carrara, S., Fugazza, A., Galtieri, P. A., Pellegatta, G., Antonelli, G., Rosch, T., Sharma, P., Hassan C., Mutignani M. (ORCID:0000-0002-1272-4888), Spada C. (ORCID:0000-0002-5692-0960), Leoni P., Fabbri C., Greco S., Cennamo V., and Giovanardi M.

Abstract

Up to 20% of health care personnel (HCP) were found to be infected with coronavirus disease (COVID-19)1 in the outbreak in northern Italy.2 Recommendations on patient and HCP protection have been made, such as postponing procedures, triage, use of personal protective equipment (PPE), and creation of differentiated in-hospital pathways.3,4 However, several barriers against the adoption of these strategies exist, including cultural factors and shortages of medical resources; therefore, there are few reports of real-world experiences and outcomes with their adoption.5 The aim of this survey was to investigate the burden of COVID-19 on endoscopic activity in a high-risk area of COVID-19 outbreak, approaches to evaluating patients, adoption and compliance of HCP with protective measures, and initial possible viral transmission outcomes from endoscopy units within a large, community-based setting (both between patients and HCP and between HCP).

Published
2020

47. T05.01.19 LONG-TERM OUTCOMES AFTER “NON-CURATIVE” ENDOSCOPIC SUBMUCOSAL DISSECTION (ESD) FOR COLORECTAL ADENOCARCINOMA

Author

Spadaccini, M., primary, Maselli, R., additional, Galtieri, P.A., additional, Anderloni, A., additional, Fugazza, A., additional, Carrara, S., additional, Ferrara, E.C., additional, Pellegatta, G., additional, Di Leo, M., additional, D'Amico, F., additional, Lamonaca, L., additional, Craviotto, V., additional, and Repici, A., additional

Published
2020
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48. OC.15.3 SAFETY AND EFFICACY OF MULTI-BAND MUCOSECTOMY IN BARRETT'S ESOPHAGUS: A SYSTEMATIC REVIEW WITH POOLED ANALYSIS

Author

Spadaccini, M., primary, Maselli, R., additional, Attardo, S., additional, Thoguluva Chandrasekar, V., additional, Galtieri, P.A., additional, Anderloni, A., additional, Fugazza, A., additional, Carrara, S., additional, Di Leo, M., additional, Pellegatta, G., additional, Ferrara, E.C., additional, Craviotto, V., additional, Lamonaca, L., additional, D'Amico, F., additional, Belletrutti, P., additional, and Repici, A., additional

Published
2020
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49. T02.01.15 GASTRIC PERORAL ENDOSCOPIC PYLOROMYOTOMY FOR REFRACTORY GASTROPARESIS: A SYSTEMATIC REVIEW OF EARLY OUTCOMES WITH POOLED ANALYSIS

Author

Spadaccini, M., primary, Maselli, R., additional, Thoguluva Chandrasekar, V., additional, Anderloni, A., additional, Carrara, S., additional, Galtieri, A.P., additional, Pellegatta, G., additional, Ferrara, E.C., additional, Di Leo, M., additional, Fugazza, A., additional, Colombo, M., additional, Palma, R., additional, Hassan, C., additional, Sethi, A., additional, Khashab, M.A., additional, and Repici, A., additional

Published
2020
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