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284 results on '"Pellegatta, Serena"'

1. Coexisting cancer stem cells with heterogeneous gene amplifications, transcriptional profiles, and malignancy are isolated from single glioblastomas

Author

De Bacco, Francesca, Orzan, Francesca, Crisafulli, Giovanni, Prelli, Marta, Isella, Claudio, Casanova, Elena, Albano, Raffaella, Reato, Gigliola, Erriquez, Jessica, D’Ambrosio, Antonio, Panero, Mara, Dall’Aglio, Carmine, Casorzo, Laura, Cominelli, Manuela, Pagani, Francesca, Melcarne, Antonio, Zeppa, Pietro, Altieri, Roberto, Morra, Isabella, Cassoni, Paola, Garbossa, Diego, Cassisa, Anna, Bartolini, Alice, Pellegatta, Serena, Comoglio, Paolo M., Finocchiaro, Gaetano, Poliani, Pietro L., and Boccaccio, Carla

Published
2023
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2. ERBB3 overexpression due to miR-205 inactivation confers sensitivity to FGF, metabolic activation, and liability to ERBB3 targeting in glioblastoma

Author

De Bacco, Francesca, Orzan, Francesca, Erriquez, Jessica, Casanova, Elena, Barault, Ludovic, Albano, Raffaella, D’Ambrosio, Antonio, Bigatto, Viola, Reato, Gigliola, Patanè, Monica, Pollo, Bianca, Kuesters, Geoffrey, Dell’Aglio, Carmine, Casorzo, Laura, Pellegatta, Serena, Finocchiaro, Gaetano, Comoglio, Paolo M., and Boccaccio, Carla

Published
2021
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5. The Immunomodulatory Effects of Fluorescein-Mediated Sonodynamic Treatment Lead to Systemic and Intratumoral Depletion of Myeloid-Derived Suppressor Cells in a Preclinical Malignant Glioma Model

Author

Pellegatta, Serena, primary, Corradino, Nicoletta, additional, Zingarelli, Manuela, additional, Porto, Edoardo, additional, Gionso, Matteo, additional, Berlendis, Arianna, additional, Durando, Gianni, additional, Maffezzini, Martina, additional, Musio, Silvia, additional, Aquino, Domenico, additional, DiMeco, Francesco, additional, and Prada, Francesco, additional

Published
2024
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7. Next‐generation agents for fluorescence‐guided glioblastoma surgery.

Author

Chirizzi, Cristina, Pellegatta, Serena, Gori, Alessandro, Falco, Jacopo, Rubiu, Emanuele, Acerbi, Francesco, and Bombelli, Francesca Baldelli

Subjects
*GLIOBLASTOMA multiforme, *TISSUE differentiation, *SURGICAL excision, *BRAIN cancer, *RADIOTHERAPY safety, TUMOR surgery
Abstract

Glioblastoma is a fast‐growing and aggressive form of brain cancer. Even with maximal treatment, patients show a low median survival and are often subjected to a high recurrence incidence. The currently available treatments require multimodal management, including maximal safe surgical resection, followed by radiation and chemotherapy. Because of the infiltrative glioblastoma nature, intraoperative differentiation of cancer tissue from normal brain parenchyma is very challenging, and this accounts for the low rate of complete tumor resection. For these reasons, clinicians have increasingly used various intraoperative adjuncts to improve surgical results, such as fluorescent agents. However, most of the existing fluorophores show several limitations such as poor selectivity, photostability, photosensitization and high costs. This could limit their application to successfully improve glioblastoma resection. In the present perspective, we highlight the possibility to develop next‐generation fluorescent tools able to more selectively label cancer cells during surgical resection. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Response assessment of GBM during immunotherapy by delayed contrast treatment response assessment maps.

Author

Cuccarini, Valeria, Savoldi, Filippo, Mardor, Yael, Last, David, Pellegatta, Serena, Mazzi, Federica, Bruzzone, Maria Grazia, Anghileri, Elena, Pollo, Bianca, Maddaloni, Luisa, Russo, Camilla, Bocchi, Elisa, Pinzi, Valentina, Eoli, Marica, and Aquino, Domenico

Subjects
TREATMENT delay (Medicine), KILLER cells, BLOOD cell count, IMMUNOTHERAPY, RECEIVER operating characteristic curves, GLIOBLASTOMA multiforme, CONTRAST-enhanced magnetic resonance imaging
Abstract

Introduction: Assessing the treatment response of glioblastoma multiforme during immunotherapy (IT) is an open issue. Treatment response assessment maps (TRAMs) might help distinguish true tumor progression (TTP) and pseudoprogression (PsP) in this setting. Methods: We recruited 16 naïve glioblastoma patients enrolled in a phase II trial consisting of the Stupp protocol (a standardized treatment for glioblastoma involving combined radiotherapy and chemotherapy with temozolomide, followed by adjuvant temozolomide) plus IT with dendritic cells. Patients were followed up till progression or death; seven underwent a second surgery for suspected progression. Clinical, immunological, and MRI data were collected from all patients and histology in case of second surgery. Patients were classified as responders (progression-free survival, PFS  >  12  months), and non-responders (PFS ≤  12), HIGH-NK (natural killer cells, i.e., immunological responders), and LOW-NK (immunological non-responders) based on immune cell counts in peripheral blood. TRAMs differentiate contrast-enhancing lesions with different washout dynamics into hypothesized tumoral (conventionally blue-colored) vs. treatment-related (red-colored). Results: Using receiver operating characteristic (ROC) curves, a threshold of −0.066 in VBlue/VCE (volume of the blue portion of tumoral area/volume of contrast enhancement) variation between values obtained in the MRI performed before PsP/TTP and at TTP/PSP allowed to discriminate TTP from PsP with a sensitivity of 71.4% and a specificity of 100%. Among HIGH-NK patients, at month 6 there was a significant reduction compared to baseline and month 2 in median “blue” volumes. Discussion: In conclusion, in our pilot study TRAMs support the discrimination between tumoral and treatment-related enhancing features in immunological responders vs. non-responders, the distinction between PsP and TTP, and might provide surrogate markers of immunological response. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Glioblastoma stem cells express non-canonical proteins and exclusive mesenchymal-like or non-mesenchymal-like protein signatures

Author

Babacic, Haris, Galardi, Silvia, Umer, Husen M., Hellström, Mats, Uhrbom, Lene, Maturi, Nagaprathyusha, Cardinali, Deborah, Pellegatta, Serena, Michienzi, Alessandro, Trevisi, Gianluca, Mangiola, Annunziato, Lehtiö, Janne, Ciafré, Silvia Anna, Pernemalm, Maria, Babacic, Haris, Galardi, Silvia, Umer, Husen M., Hellström, Mats, Uhrbom, Lene, Maturi, Nagaprathyusha, Cardinali, Deborah, Pellegatta, Serena, Michienzi, Alessandro, Trevisi, Gianluca, Mangiola, Annunziato, Lehtiö, Janne, Ciafré, Silvia Anna, and Pernemalm, Maria

Abstract

Glioblastoma (GBM) cancer stem cells (GSCs) contribute to GBM's origin, recurrence, and resistance to treatment. However, the understanding of how mRNA expression patterns of GBM subtypes are reflected at global proteome level in GSCs is limited. To characterize protein expression in GSCs, we performed in-depth proteogenomic analysis of patient-derived GSCs by RNA-sequencing and mass-spectrometry. We quantified > 10 000 proteins in two independent GSC panels and propose a GSC-associated proteomic signature characterizing two distinct phenotypic conditions; one defined by proteins upregulated in proneural and classical GSCs (GPC-like), and another by proteins upregulated in mesenchymal GSCs (GM-like). The GM-like protein set in GBM tissue was associated with necrosis, recurrence, and worse overall survival. Through proteogenomics, we discovered 252 non-canonical peptides in the GSCs, i.e., protein sequences that are variant or derive from genome regions previously considered non-protein-coding, including variants of the heterogeneous ribonucleoproteins implicated in RNA splicing. In summary, GSCs express two protein sets that have an inverse association with clinical outcomes in GBM. The discovery of non-canonical protein sequences questions existing gene models and pinpoints new protein targets for research in GBM.

Published
2023
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10. Data from Modifications to the Framework Regions Eliminate Chimeric Antigen Receptor Tonic Signaling

Author

Landoni, Elisa, primary, Fucá, Giovanni, primary, Wang, Jian, primary, Chirasani, Venkat R., primary, Yao, Zhiyuan, primary, Dukhovlinova, Elena, primary, Ferrone, Soldano, primary, Savoldo, Barbara, primary, Hong, Lee K., primary, Shou, Peishun, primary, Musio, Silvia, primary, Padelli, Francesco, primary, Finocchiaro, Gaetano, primary, Droste, Miriam, primary, Kuhlman, Brian, primary, Shamshiev, Abdijapar, primary, Pellegatta, Serena, primary, Dokholyan, Nikolay V., primary, and Dotti, Gianpietro, primary

Published
2023
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11. Abstract 4694: Single-cell analysis of glioblastoma immune contexture identifies a subset of activated and memory tumor-reactive CD8+ TILs and a Treg signature contributing to TIL irreversible dysfunction

Author

Sambruni, Irene, primary, Musio, Silvia, additional, Ianni, Natalia Di, additional, Maffezzini, Martina, additional, Patanè, Monica, additional, Eoli, Marica, additional, Silvani, Antonio, additional, Pollo, Bianca, additional, DiMeco, Francesco, additional, and Pellegatta, Serena, additional

Published
2023
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12. Supplementary Figures 1-8 from Modifications to the Framework Regions Eliminate Chimeric Antigen Receptor Tonic Signaling

Author

Landoni, Elisa, primary, Fucá, Giovanni, primary, Wang, Jian, primary, Chirasani, Venkat R., primary, Yao, Zhiyuan, primary, Dukhovlinova, Elena, primary, Ferrone, Soldano, primary, Savoldo, Barbara, primary, Hong, Lee K., primary, Shou, Peishun, primary, Musio, Silvia, primary, Padelli, Francesco, primary, Finocchiaro, Gaetano, primary, Droste, Miriam, primary, Kuhlman, Brian, primary, Shamshiev, Abdijapar, primary, Pellegatta, Serena, primary, Dokholyan, Nikolay V., primary, and Dotti, Gianpietro, primary

Published
2023
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13. Data from The MET Oncogene Is a Functional Marker of a Glioblastoma Stem Cell Subtype

Author

De Bacco, Francesca, primary, Casanova, Elena, primary, Medico, Enzo, primary, Pellegatta, Serena, primary, Orzan, Francesca, primary, Albano, Raffaella, primary, Luraghi, Paolo, primary, Reato, Gigliola, primary, D'Ambrosio, Antonio, primary, Porrati, Paola, primary, Patanè, Monica, primary, Maderna, Emanuela, primary, Pollo, Bianca, primary, Comoglio, Paolo M., primary, Finocchiaro, Gaetano, primary, and Boccaccio, Carla, primary

Published
2023
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14. Supplementary Table 1 from The MET Oncogene Is a Functional Marker of a Glioblastoma Stem Cell Subtype

Author

De Bacco, Francesca, primary, Casanova, Elena, primary, Medico, Enzo, primary, Pellegatta, Serena, primary, Orzan, Francesca, primary, Albano, Raffaella, primary, Luraghi, Paolo, primary, Reato, Gigliola, primary, D'Ambrosio, Antonio, primary, Porrati, Paola, primary, Patanè, Monica, primary, Maderna, Emanuela, primary, Pollo, Bianca, primary, Comoglio, Paolo M., primary, Finocchiaro, Gaetano, primary, and Boccaccio, Carla, primary

Published
2023
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15. Supplementary Table 7 from The MET Oncogene Is a Functional Marker of a Glioblastoma Stem Cell Subtype

Author

De Bacco, Francesca, primary, Casanova, Elena, primary, Medico, Enzo, primary, Pellegatta, Serena, primary, Orzan, Francesca, primary, Albano, Raffaella, primary, Luraghi, Paolo, primary, Reato, Gigliola, primary, D'Ambrosio, Antonio, primary, Porrati, Paola, primary, Patanè, Monica, primary, Maderna, Emanuela, primary, Pollo, Bianca, primary, Comoglio, Paolo M., primary, Finocchiaro, Gaetano, primary, and Boccaccio, Carla, primary

Published
2023
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16. Supplementary Tables 2-8 from The MET Oncogene Is a Functional Marker of a Glioblastoma Stem Cell Subtype

Author

De Bacco, Francesca, primary, Casanova, Elena, primary, Medico, Enzo, primary, Pellegatta, Serena, primary, Orzan, Francesca, primary, Albano, Raffaella, primary, Luraghi, Paolo, primary, Reato, Gigliola, primary, D'Ambrosio, Antonio, primary, Porrati, Paola, primary, Patanè, Monica, primary, Maderna, Emanuela, primary, Pollo, Bianca, primary, Comoglio, Paolo M., primary, Finocchiaro, Gaetano, primary, and Boccaccio, Carla, primary

Published
2023
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17. Supplementary Table S1 from Neurospheres Enriched in Cancer Stem–Like Cells Are Highly Effective in Eliciting a Dendritic Cell–Mediated Immune Response against Malignant Gliomas

Author

Pellegatta, Serena, primary, Poliani, Pietro Luigi, primary, Corno, Daniela, primary, Menghi, Francesca, primary, Ghielmetti, Francesco, primary, Suarez-Merino, Blanca, primary, Caldera, Valentina, primary, Nava, Sara, primary, Ravanini, Maria, primary, Facchetti, Fabio, primary, Bruzzone, Maria Grazia, primary, and Finocchiaro, Gaetano, primary

Published
2023
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18. Supplementary Materials and Methods and Figures 1 - 3 from Sox2 Is Required to Maintain Cancer Stem Cells in a Mouse Model of High-Grade Oligodendroglioma

Author

Favaro, Rebecca, primary, Appolloni, Irene, primary, Pellegatta, Serena, primary, Sanga, Alexandra Badiola, primary, Pagella, Pierfrancesco, primary, Gambini, Eleonora, primary, Pisati, Federica, primary, Ottolenghi, Sergio, primary, Foti, Maria, primary, Finocchiaro, Gaetano, primary, Malatesta, Paolo, primary, and Nicolis, Silvia K., primary

Published
2023
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19. Supplementary Materials and Methods from The MET Oncogene Is a Functional Marker of a Glioblastoma Stem Cell Subtype

Author

De Bacco, Francesca, primary, Casanova, Elena, primary, Medico, Enzo, primary, Pellegatta, Serena, primary, Orzan, Francesca, primary, Albano, Raffaella, primary, Luraghi, Paolo, primary, Reato, Gigliola, primary, D'Ambrosio, Antonio, primary, Porrati, Paola, primary, Patanè, Monica, primary, Maderna, Emanuela, primary, Pollo, Bianca, primary, Comoglio, Paolo M., primary, Finocchiaro, Gaetano, primary, and Boccaccio, Carla, primary

Published
2023
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20. Supplementary Table 1 from Sox2 Is Required to Maintain Cancer Stem Cells in a Mouse Model of High-Grade Oligodendroglioma

Author

Favaro, Rebecca, primary, Appolloni, Irene, primary, Pellegatta, Serena, primary, Sanga, Alexandra Badiola, primary, Pagella, Pierfrancesco, primary, Gambini, Eleonora, primary, Pisati, Federica, primary, Ottolenghi, Sergio, primary, Foti, Maria, primary, Finocchiaro, Gaetano, primary, Malatesta, Paolo, primary, and Nicolis, Silvia K., primary

Published
2023
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21. Supplementary Methods and Figures 1-8 from Neurospheres Enriched in Cancer Stem–Like Cells Are Highly Effective in Eliciting a Dendritic Cell–Mediated Immune Response against Malignant Gliomas

Author

Pellegatta, Serena, primary, Poliani, Pietro Luigi, primary, Corno, Daniela, primary, Menghi, Francesca, primary, Ghielmetti, Francesco, primary, Suarez-Merino, Blanca, primary, Caldera, Valentina, primary, Nava, Sara, primary, Ravanini, Maria, primary, Facchetti, Fabio, primary, Bruzzone, Maria Grazia, primary, and Finocchiaro, Gaetano, primary

Published
2023
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22. Data from Sox2 Is Required to Maintain Cancer Stem Cells in a Mouse Model of High-Grade Oligodendroglioma

Author

Favaro, Rebecca, primary, Appolloni, Irene, primary, Pellegatta, Serena, primary, Sanga, Alexandra Badiola, primary, Pagella, Pierfrancesco, primary, Gambini, Eleonora, primary, Pisati, Federica, primary, Ottolenghi, Sergio, primary, Foti, Maria, primary, Finocchiaro, Gaetano, primary, Malatesta, Paolo, primary, and Nicolis, Silvia K., primary

Published
2023
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23. Supplementary Figures 1-9 from The MET Oncogene Is a Functional Marker of a Glioblastoma Stem Cell Subtype

Author

De Bacco, Francesca, primary, Casanova, Elena, primary, Medico, Enzo, primary, Pellegatta, Serena, primary, Orzan, Francesca, primary, Albano, Raffaella, primary, Luraghi, Paolo, primary, Reato, Gigliola, primary, D'Ambrosio, Antonio, primary, Porrati, Paola, primary, Patanè, Monica, primary, Maderna, Emanuela, primary, Pollo, Bianca, primary, Comoglio, Paolo M., primary, Finocchiaro, Gaetano, primary, and Boccaccio, Carla, primary

Published
2023
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25. Glioblastoma stem cells express non‐canonical proteins and exclusive mesenchymal‐like or non‐mesenchymal‐like protein signatures

Author

Babačić, Haris, primary, Galardi, Silvia, additional, Umer, Husen M., additional, Hellström, Mats, additional, Uhrbom, Lene, additional, Maturi, Nagaprathyusha, additional, Cardinali, Deborah, additional, Pellegatta, Serena, additional, Michienzi, Alessandro, additional, Trevisi, Gianluca, additional, Mangiola, Annunziato, additional, Lehtiö, Janne, additional, Ciafrè, Silvia Anna, additional, and Pernemalm, Maria, additional

Published
2023
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27. Resetting cancer stem cell regulatory nodes upon MYC inhibition

Author

Galardi, Silvia, Savino, Mauro, Scagnoli, Fiorella, Pellegatta, Serena, Pisati, Federica, Zambelli, Federico, Illi, Barbara, Annibali, Daniela, Beji, Sara, Orecchini, Elisa, Alberelli, Maria Adele, Apicella, Clara, Fontanella, Rosaria Anna, Michienzi, Alessandro, Finocchiaro, Gaetano, Farace, Maria Giulia, Pavesi, Giulio, Ciafrè, Silvia Anna, and Nasi, Sergio

Published
2016
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28. MET inhibition overcomes radiation resistance of glioblastoma stem‐like cells

Author

De Bacco, Francesca, D'Ambrosio, Antonio, Casanova, Elena, Orzan, Francesca, Neggia, Roberta, Albano, Raffaella, Verginelli, Federica, Cominelli, Manuela, Poliani, Pietro L, Luraghi, Paolo, Reato, Gigliola, Pellegatta, Serena, Finocchiaro, Gaetano, Perera, Timothy, Garibaldi, Elisabetta, Gabriele, Pietro, Comoglio, Paolo M, and Boccaccio, Carla

Published
2016
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30. Transforming Fusions of FGFR and TACC Genes in Human Glioblastoma

Author

Singh, Devendra, Chan, Joseph Minhow, Zoppoli, Pietro, Niola, Francesco, Sullivan, Ryan, Castano, Angelica, Liu, Eric Minwei, Reichel, Jonathan, Porrati, Paola, Pellegatta, Serena, Qiu, Kunlong, Gao, Zhibo, Ceccarelli, Michele, Riccardi, Riccardo, Brat, Daniel J., Guha, Abhijit, Aldape, Ken, Golfinos, John G., Zagzag, David, Mikkelsen, Tom, Finocchiaro, Gaetano, Lasorella, Anna, Rabadan, Raul, and Iavarone, Antonio

Published
2012
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31. EGFR Amplified and Overexpressing Glioblastomas and Association With Better Response to Adjuvant Metronomic Temozolomide

Author

Cominelli, Manuela, Grisanti, Salvatore, Mazzoleni, Stefania, Branca, Caterina, Buttolo, Luciano, Furlan, Daniela, Liserre, Barbara, Bonetti, Maria Fausta, Medicina, Daniela, Pellegrini, Vilma, Buglione, Michela, Liserre, Roberto, Pellegatta, Serena, Finocchiaro, Gaetano, Dalerba, Piero, Facchetti, Fabio, Pizzi, Marina, Galli, Rossella, and Poliani, Pietro Luigi

Published
2015
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32. Deciphering the Labyrinthine System of the Immune Microenvironment in Recurrent Glioblastoma: Recent Original Advances and Lessons from Clinical Immunotherapeutic Approaches

Author

Anghileri, Elena, primary, Patanè, Monica, additional, Di Ianni, Natalia, additional, Sambruni, Irene, additional, Maffezzini, Martina, additional, Milani, Micaela, additional, Maddaloni, Luisa, additional, Pollo, Bianca, additional, Eoli, Marica, additional, and Pellegatta, Serena, additional

Published
2021
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36. Abstract 942: ErbB3 overexpression unleashed by miR-205 epigenetic silencing is a therapeutic target in glioblastoma

Author

De Bacco, Francesca, primary, Orzan, Francesca, additional, Erriquez, Jessica, additional, Casanova, Elena, additional, Barault, Ludovic, additional, Albano, Raffaella, additional, D'Ambrosio, Antonio, additional, Bigatto, Viola, additional, Reato, Gigliola, additional, Patané, Monica, additional, Pollo, Bianca, additional, Kuesters, Geoffrey, additional, Dell'Aglio, Carmine, additional, Casorzo, Laura, additional, Pellegatta, Serena, additional, Finocchiaro, Gaetano, additional, Comoglio, Paolo M., additional, and Boccaccio, Carla, additional

Published
2021
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38. Sonodynamic Therapy for the Treatment of Intracranial Gliomas

Author

D’Ammando, Antonio, primary, Raspagliesi, Luca, additional, Gionso, Matteo, additional, Franzini, Andrea, additional, Porto, Edoardo, additional, Di Meco, Francesco, additional, Durando, Giovanni, additional, Pellegatta, Serena, additional, and Prada, Francesco, additional

Published
2021
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42. Modifications to the Framework Regions Eliminate Chimeric Antigen Receptor Tonic Signaling

Author

Landoni, Elisa, primary, Fucá, Giovanni, additional, Wang, Jian, additional, Chirasani, Venkat R., additional, Yao, Zhiyuan, additional, Dukhovlinova, Elena, additional, Ferrone, Soldano, additional, Savoldo, Barbara, additional, Hong, Lee K., additional, Shou, Peishun, additional, Musio, Silvia, additional, Padelli, Francesco, additional, Finocchiaro, Gaetano, additional, Droste, Miriam, additional, Kuhlman, Brian, additional, Shamshiev, Abdijapar, additional, Pellegatta, Serena, additional, Dokholyan, Nikolay V., additional, and Dotti, Gianpietro, additional

Published
2021
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43. Abstract PO087: Radiotherapy treatment in combination with Dendritic Cell Immunotherapy promotes a microglia activation and a disruption of the SIRPα-CD47 signaling axis in the GL261 glioma model

Author

Pellegatta, Serena, primary, Di Ianni, Natalia, additional, Maffezzini, Martina, additional, Fumagalli, Maria Luisa, additional, Pinzi, Valentina, additional, Musio, Silvia, additional, Fariselli, Laura, additional, and Finocchiaro, Gaetano, additional

Published
2021
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45. High tumor mutational burden and T-cell activation are associated with long-term response to anti-PD1 therapy in Lynch syndrome recurrent glioblastoma patient

Author

Anghileri, Elena, primary, Di Ianni, Natalia, additional, Paterra, Rosina, additional, Langella, Tiziana, additional, Zhao, Junfei, additional, Eoli, Marica, additional, Patanè, Monica, additional, Pollo, Bianca, additional, Cuccarini, Valeria, additional, Iavarone, Antonio, additional, Rabadan, Raul, additional, Finocchiaro, Gaetano, additional, and Pellegatta, Serena, additional

Published
2020
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48. MR-Spectroscopy and Survival in Mice with High Grade Glioma Undergoing Unrestricted Ketogenic Diet.

Author

Ciusani, Emilio, Vasco, Chiara, Rizzo, Ambra, Girgenti, Vita, Padelli, Francesco, Pellegatta, Serena, Fariselli, Laura, Bruzzone, Maria Grazia, and Salmaggi, Andrea

Subjects
KETOGENIC diet, CELL culture, ANIMAL experimentation, GLIOMAS, NUCLEAR magnetic resonance spectroscopy, MITOCHONDRIA, SURVIVAL analysis (Biometry), RESEARCH funding, MICE
Abstract

Glioblastoma multiforme (GBM) is considered the most malignant form of primary brain tumor. Despite multimodal treatment, prognosis remains poor. Ketogenic diet (KD) has been suggested for the treatment of GBM. In this study, the syngenic, orthotopic GL261 mouse glioma model was used to evaluate the effects of KD on the metabolic responses of the tumor using 7T magnetic resonance imaging/spectroscopy. GL261 cells were injected into the caudate nucleus of mice. Following implantation, animals were fed with standard chow or underwent a KD. 18 days after initiating the diet, mice fed with KD displayed significantly higher plasmatic levels of ketone bodies and survived longer than those fed with the standard diet. Decreased concentrations of gamma-aminobutyric acid, N-Acetyl-Aspartate and N-acetylaspartylglutamate were found in tumor tissue after 9 days into the KD, while a huge increase in beta-hydroxybutyrate (bHB) was detected in tumor tissue as compared to normal brain. The accumulation of bHB in the tumor tissue in mice undergoing the KD, may suggest either elevated uptake/release of bHB by tumor cells, or the inability of tumor cells in this context to use it for mitochondrial metabolism. [ABSTRACT FROM AUTHOR]

Published
2021
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50. Expansion of effector and memory T cells is associated with increased survival in recurrent glioblastomas treated with dendritic cell immunotherapy

Author

Eoli, Marica, primary, Corbetta, Cristina, primary, Anghileri, Elena, primary, Di Ianni, Natalia, primary, Milani, Micaela, primary, Cuccarini, Valeria, primary, Musio, Silvia, primary, Paterra, Rosina, primary, Frigerio, Simona, primary, Nava, Sara, primary, Lisini, Daniela, primary, Pessina, Sara, primary, Maddaloni, Luisa, primary, Lombardi, Raffaella, primary, Tardini, Maria, primary, Ferroli, Paolo, primary, DiMeco, Francesco, primary, Bruzzone, Maria Grazia, primary, Antozzi, Carlo, primary, Pollo, Bianca, primary, Finocchiaro, Gaetano, primary, and Pellegatta, Serena, primary

Published
2019
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