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142 results on '"Pelizzari, Laura"'

2. Transvaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) in Urogynecological Surgery: A Systematic Review.

Author

Vacca, Lorenzo, Rosato, Eleonora, Lombardo, Riccardo, Geretto, Paolo, Albisinni, Simone, Campi, Riccardo, De Cillis, Sabrina, Pelizzari, Laura, Gallo, Maria Lucia, Sampogna, Gianluca, Lombisani, Andrea, Campagna, Giuseppe, Giammo, Alessandro, Li Marzi, Vincenzo, and De Nunzio, Cosimo

Abstract

Background: Minimally invasive surgery could improve cosmetic outcomes and reduce the risks of surgical injury with less postoperative pain and a quicker patient's discharge. Recently, transvaginal natural orifice transluminal endoscopic surgery (vNOTES) has been introduced in urogynecology with exciting results. Evidence Acquisition: After PROSPERO registration (n°CRD42023406815), we performed a comprehensive literature search on Pubmed, Embase, and Cochrane CENTRAL, including peer-reviewed studies evaluating transvaginal natural orifice transluminal endoscopic surgery. No limits on time or type of study were applied. Evidence synthesis: Overall, 12 manuscripts were included in the analysis. Seven studies evaluated uterosacral ligament suspension, four studies evaluated sacral colpopexy, three evaluated sacrospinous ligament suspension, and one study evaluated lateral suspension. Overall success rates were high (>90%); however, definitions of success were heterogeneous. In terms of complication, most of the studies reported low-grade complications (Clavien–Dindo I and II); only two patients needed mesh removal because of mesh exposure. The risk of bias of the trials was rated in the medium to high-risk category. Conclusions: The present review highlights important initial results for vNOTES. Future randomized clinical trials are needed to better define its role in the management of urogynecological procedures. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Bowel Dysfunctions in Disorders of Consciousness after Acquired Brain Injury: a scoping review protocol

Author

Ciardi, Gianluca, Lamberti, Gianfranco, Frizziero, Antonio, Zandalasini, Matteo, Pelizzari, Laura, Paravati, Stefano, Feltroni, Lucia, and Guasconi, Massimo

Subjects
disorders of counsciousness, Medicine and Health Sciences, bowel dysfunction, acute brain injury, conservative treatment, rehabilitation
Abstract

Bowel dysfunction is a common cmorbidity for neurologic disease patients, with a great impact on quality of life and an increasing social impairment.

Published
2022
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24. Cardiac and Respiratory Influences on Intracranial and Neck Venous Flow, Estimated Using Real-Time Phase-Contrast MRI

Author

Laganà, Maria Marcella, Pirastru, Alice, Ferrari, Francesca, Di Tella, Sonia, Cazzoli, Marta, Pelizzari, Laura, Jin, Ning, Zacà, Domenico, Alperin, Noam, Baselli, Giuseppe, Baglio, Francesca, Di Tella, Sonia (ORCID:0000-0002-2248-5120), Laganà, Maria Marcella, Pirastru, Alice, Ferrari, Francesca, Di Tella, Sonia, Cazzoli, Marta, Pelizzari, Laura, Jin, Ning, Zacà, Domenico, Alperin, Noam, Baselli, Giuseppe, Baglio, Francesca, and Di Tella, Sonia (ORCID:0000-0002-2248-5120)

Abstract

The study of brain venous drainage has gained attention due to its hypothesized link with various neurological conditions. Intracranial and neck venous flow rate may be estimated using cardiac-gated cine phase-contrast (PC)-MRI. Although previous studies showed that breathing influences the neck's venous flow, this aspect could not be studied using the conventional segmented PC-MRI since it reconstructs a single cardiac cycle. The advent of real-time PC-MRI has overcome these limitations. Using this technique, we measured the internal jugular veins and superior sagittal sinus flow rates in a group of 16 healthy subjects (12 females, median age of 23 years). Comparing forced-breathing and free-breathing, the average flow rate decreased and the respiratory modulation increased. The flow rate decrement may be due to a vasoreactive response to deep breathing. The respiratory modulation increment is due to the thoracic pump's greater effect during forced breathing compared to free breathing. These results showed that the breathing mode influences the average blood flow and its pulsations. Since effective drainage is fundamental for brain health, rehabilitative studies might use the current setup to investigate if respiratory exercises positively affect clinical variables and venous drainage.

Published
2022

29. Multimodal Evaluation of Neurovascular Functionality in Early Parkinson's Disease

Author

Laganà, Maria Marcella, Pirastru, Alice, Pelizzari, Laura, Rossetto, Federica, Di Tella, Sonia, Bergsland, Niel, Nemni, Raffaello, Meloni, Mario, Baglio, Francesca, Di Tella, Sonia (ORCID:0000-0002-2248-5120), Laganà, Maria Marcella, Pirastru, Alice, Pelizzari, Laura, Rossetto, Federica, Di Tella, Sonia, Bergsland, Niel, Nemni, Raffaello, Meloni, Mario, Baglio, Francesca, and Di Tella, Sonia (ORCID:0000-0002-2248-5120)

Abstract

Parkinson's disease (PD) is a multisystem neurological condition affecting different neurotransmitter pathways characterized by aberrant functional connectivity (FC) and perfusion alteration. Since the FC, measuring neuronal activity, and cerebral blood flow (CBF) are closely related through the neurovascular coupling (NVC) mechanism, we aim to assess whether FC changes found in PD mirror perfusion ones. A multimodal MRI study was implemented by acquiring resting state functional MRI (rsfMRI) and arterial spin labeling (ASL) datasets on a group of 26 early PD (66.8 +/- 8 years, 22 males, median [interquartile range] Hoehn and Yahr = 1.5 [1]) and 18 age- and sex-matched healthy controls (HCs). In addition, a T1-weighted MPRAGE was also acquired in the same scan session. After a standard preprocessing, resting state networks (RSNs) and CBF maps were extracted from rsfMRI and ASL dataset, respectively. Then, by means of a dual regression algorithm performed on RSNs, a cluster of FC differences between groups was obtained and used to mask CBF maps in the subsequent voxel-wise group comparison. Furthermore, a gray matter (GM) volumetric assessment was performed within the FC cluster in order to exclude tissue atrophy as a source of functional changes. Reduced FC for a PD patient with respect to HC group was found within a sensory-motor network (SMN, p(FWE)= 0.01) and visual networks (VNs, primary p(FWE)= 0.022 and lateral p(FWE)= 0.01). The latter was accompanied by a decreased CBF (primary p(FWE)= 0.037, lateral p(FWE)= 0.014 VNs), while no GM atrophy was detected instead. The FC alteration found in the SMN of PD might be likely due to a dopaminergic denervation of the striatal pathways causing a functional disconnection. On the other hand, the changes in connectivity depicted in VNs might be related to an altered non-dopaminergic system, since perfusion was also reduced, revealing a compromised NVC. Finally, the absence of GM volume loss might imply that functional cha

Published
2020

30. Parietal Perfusion Alterations in Parkinson's Disease Patients Without Dementia

Author

Pelizzari, Laura, Di Tella, Sonia, Rossetto, Federica, Laganà, Maria Marcella, Bergsland, Niel, Pirastru, Alice, Meloni, Mario, Nemni, Raffaello, Baglio, Francesca, Di Tella, Sonia (ORCID:0000-0002-2248-5120), Pelizzari, Laura, Di Tella, Sonia, Rossetto, Federica, Laganà, Maria Marcella, Bergsland, Niel, Pirastru, Alice, Meloni, Mario, Nemni, Raffaello, Baglio, Francesca, and Di Tella, Sonia (ORCID:0000-0002-2248-5120)

Abstract

Fronto-parietal regions are involved in cognitive processes that are commonly affected in Parkinson's disease (PD). The aims of this study were to investigate cerebral blood flow (CBF) and gray matter (GM) volume within the regions belonging to the fronto-parietal circuit in people with PD (pwPD) without dementia, and to assess their association with cognitive performance. Twenty-seven pwPD without dementia (mean [SD] age = 67.4 [8.1] years, 20 males, mean [SD] Montreal Cognitive Assessment, MoCA score = 24.2 [2.9], median [IQR] Hoehn and Yahr scale = 1.5 [1-2]) and twenty-six age- and sex-matched healthy controls (HC) were scanned with arterial spin labeling (ASL) and T1-weighted magnetic resonance imaging (MRI) sequences to investigate CBF and GM volume, respectively. The cognitive performance of the enrolled pwPD was assessed with MoCA, Trail Making Test (TMT, part A, B, B-A), phonemic fluency and semantic fluency tests. The scores were adjusted for age and education. After standard preprocessing, CBF differences between pwPD and HC were tested with a voxel-wise approach. Voxel-based morphometry was used to compare pwPD and HC in terms of GM volume. Both voxel-wise comparisons between pwPD and HC were restricted to regions of the fronto-parietal circuit. The following additional voxel-wise analyses were performed within regions showing either perfusion or GM volume alterations: (1) correlation with neuropsychological test scores; (2) subgroup comparison after median split on each neuropsychological test score. Family-wise error-corrected (FWE)p-values lower than 0.05 were considered significant. Significant hypoperfusion was identified in the left inferior parietal lobule (IPL, p(peak)= 0.037) and in the bilateral superior parietal lobule (SPL, left hemisphere: p(peak)= 0.037; right hemisphere: p(peak)= 0.049) of pwPD when compared to HC. No significant GM atrophy was observed. Local hypoperfusion did not correlate with any neuropsychological test scores. However

Published
2020

35. supplementary – Supplemental material for Cerebral blood flow and cerebrovascular reactivity correlate with severity of motor symptoms in Parkinson’s disease

Author

Pelizzari, Laura, Laganà, Maria Marcella, Rossetto, Federica, Bergsland, Niels, Galli, Mirco, Baselli, Giuseppe, Clerici, Mario, Nemni, Raffaello, and Baglio, Francesca

Subjects
FOS: Clinical medicine, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, supplementary for Cerebral blood flow and cerebrovascular reactivity correlate with severity of motor symptoms in Parkinson’s disease by Laura Pelizzari, Maria Marcella Laganà, Federica Rossetto, Niels Bergsland, Mirco Galli, Giuseppe Baselli, Mario Clerici, Raffaello Nemni and Francesca Baglio in Therapeutic Advances in Neurological Disorders

Published
2019
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36. Pelvic floor muscle training: Novel versus traditional remote rehabilitation methods—A systematic review and meta‐analysis on their effectiveness for women with urinary incontinence.

Author

Sampogna, Gianluca, Pelizzari, Laura, Lombardo, Riccardo, De Nunzio, Cosimo, and Li Marzi, Vincenzo

Subjects
KEGEL exercises, PELVIC floor, URINARY incontinence in women, REHABILITATION, PATIENT reported outcome measures, MEDICAL quality control
Abstract

PROMs from the first 100 patients who answered the questionnaire and agreed to share their data for research purposes showed that most patients were not worried about inappropriate management via telerehabilitation (median: 2; range: 1-10) and felt satisfied after this service (median: 10; range: 4-10). Supervised exercise therapy compared with no exercise therapy to reverse debilitating effects of androgen deprivation therapy in patients with prostate cancer: a systematic review and meta-analysis. We read with interest the review by Papanikolaou et al. comparing novel vs traditional rehabilitation methods in women with urinary incontinence.[1] The authors have the merit of performing a systematic search following precisely the PRISMA guidelines. [Extracted from the article]

Published
2023
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46. Lipoprotein(a) Levels Are Associated with the Size of Extracranial Arteries in Multiple Sclerosis.

Author

Jakimovski, Dejan, Zivadinov, Robert, Pelizzari, Laura, Browne, Richard W., Weinstock-Guttman, Bianca, and Ramanathan, Murali

Subjects
ARTERIOSCLEROSIS, MULTIPLE sclerosis, MAGNETIC resonance angiography, VERTEBRAL artery, CAROTID artery
Abstract

Background: Hyperlipidemia is associated with worse clinical and radiological outcomes in persons with multiple sclerosis (PwMS) and studies show greater MS extracranial arterial vessel pathology. Objective: The aim of this study was to determine the effect of lipid profile measures on extracranial arterial vessels in PwMS and healthy controls (HCs). Methods: Non-contrast magnetic resonance angiography was conducted on 104 PwMS and 41 HCs. The cross-sectional area (CSA) of the common carotid artery (CCA) and vertebral artery (VA) was measured using a semi-automated edge-detection/contouring method at cervical levels C4-C7. The lipid profile was obtained at the time of the scan. Repeated measures analyses adjusted for age, gender, and body mass index were used. Results: In PwMS, age was associated with CCA CSA (F = 7.65, η2 = 0.083, p = 0.007) and lipoprotein(a) [Lp(a)] with VA CSA (F = 13.4, η2 = 0.13, p < 0.001). These associations were not present in HCs. PwMS with Lp(a) ≥30 and ≥50 mg/dL, and within the highest Lp(a) quartile had significantly larger CCA and VA when compared to those with lower Lp(a) threshold values. Total cholesterol and low- and high-density lipoprotein cholesterol were not associated with CCA or VA CSA. Conclusions: Lp(a) levels are associated with CSA of major extracranial arterial vessels in PwMS but not in HCs. The clinical and pathological significance of these associations, if any, remains unknown. [ABSTRACT FROM AUTHOR]

Published
2020
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