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36 results on '"Pelissier, Fanny A."'

1. Microenvironment rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factors

Author

Lin, Chun-Han, Pelissier, Fanny A, Zhang, Hui, Lakins, Jon, Weaver, Valerie M, Park, Catherine, and LaBarge, Mark A

Subjects
Biochemistry and Cell Biology, Biological Sciences, Cancer, Genetics, Breast Cancer, Women's Health, 5.1 Pharmaceuticals, 2.1 Biological and endogenous factors, Acyltransferases, Animals, Antineoplastic Agents, Breast Neoplasms, Cell Cycle Proteins, Cell Line, Tumor, Cell Proliferation, Down-Regulation, Drug Resistance, Neoplasm, Female, Humans, Lapatinib, Mice, Mice, Knockout, Mice, Nude, Nuclear Proteins, Porphyrins, Protein Kinase Inhibitors, Quinazolines, RNA, Small Interfering, Receptor, ErbB-2, Signal Transduction, Transcription Factors, Tumor Microenvironment, Verteporfin, Xenograft Model Antitumor Assays, Receptor, erbB-2, Medical and Health Sciences, Developmental Biology, Biochemistry and cell biology
Abstract

Stiffness is a biophysical property of the extracellular matrix that modulates cellular functions, including proliferation, invasion, and differentiation, and it also may affect therapeutic responses. Therapeutic durability in cancer treatments remains a problem for both chemotherapies and pathway-targeted drugs, but the reasons for this are not well understood. Tumor progression is accompanied by changes in the biophysical properties of the tissue, and we asked whether matrix rigidity modulated the sensitive versus resistant states in HER2-amplified breast cancer cell responses to the HER2-targeted kinase inhibitor lapatinib. The antiproliferative effect of lapatinib was inversely proportional to the elastic modulus of the adhesive substrata. Down-regulation of the mechanosensitive transcription coactivators YAP and TAZ, either by siRNA or with the small-molecule YAP/TEAD inhibitor verteporfin, eliminated modulus-dependent lapatinib resistance. Reduction of YAP in vivo in mice also slowed the growth of implanted HER2-amplified tumors, showing a trend of increasing sensitivity to lapatinib as YAP decreased. Thus we address the role of stiffness in resistance to and efficacy of a HER2 pathway-targeted therapeutic via the mechanotransduction arm of the Hippo pathway.

Published
2015

3. Age-related dysfunction in mechanotransduction impairs differentiation of human mammary epithelial progenitors.

Author

Pelissier, Fanny A, Garbe, James C, Ananthanarayanan, Badriprasad, Miyano, Masaru, Lin, ChunHan, Jokela, Tiina, Kumar, Sanjay, Stampfer, Martha R, Lorens, James B, and LaBarge, Mark A

Subjects
Mammary Glands, Human, Epithelial Cells, Stem Cells, Humans, Adaptor Proteins, Signal Transducing, Phosphoproteins, Transcription Factors, Age Factors, Mechanotransduction, Cellular, Cell Differentiation, Adult, Middle Aged, Female, Mammary Glands, Human, Adaptor Proteins, Signal Transducing, Mechanotransduction, Cellular, Stem Cell Research - Nonembryonic - Non-Human, Stem Cell Research, Stem Cell Research - Nonembryonic - Human, Aging, 1.1 Normal biological development and functioning, Biochemistry and Cell Biology, Medical Physiology
Abstract

Dysfunctional progenitor and luminal cells with acquired basal cell properties accumulate during human mammary epithelial aging for reasons not understood. Multipotent progenitors from women aged 55 years is unaffected by physiological stiffness changes. Efficient activation of Hippo pathway transducers YAP and TAZ is required for the modulus-dependent myoepithelial/basal bias in younger progenitors. In older progenitors, YAP and TAZ are activated only when stressed with extraphysiologically stiff matrices, which bias differentiation towards luminal-like phenotypes. In vivo YAP is primarily active in myoepithelia of younger breasts, but localization and activity increases in luminal cells with age. Thus, aging phenotypes of mammary epithelia may arise partly because alterations in Hippo pathway activation impair microenvironment-directed differentiation and lineage specificity.

Published
2014

4. Trends in poisoning associated with the use of insecticides for bed bug infestations: a 20-year retrospective study in France.

Author

Laborde-Castérot, Hervé, Vodovar, Dominique, Ortiz De Zevallos, Adrian, Caré, Weniko, Nisse, Patrick, Bargel, Sophie, Rambourg, Marie-Odile, Langrand, Jérôme, Paret, Nathalie, Chevallier, Cécile, Facile, Anthony, Czerwiec, Aurore, Azzouz, Ramy, Garat, Anne, Leroux, Gael, Deguigne, Marie, Legeay, Marion, Descatha, Alexis, Delcourt, Nicolas, and Pelissier, Fanny

Subjects
BEDBUGS, INSECTICIDES, POISONING, POISON control centers, PUBLIC health, PEST control
Abstract

Bed bugs are pervasive global pests that have reemerged in the last 20 years as a significant public health concern, especially in densely populated urban areas. Beyond financial losses, expenses, inconvenience, and psychological distress, bed bug infestations often necessitate chemical management, posing poisoning risks to those with an infestation. The French Poison Control Centers recorded 1056 cases of exposure to bed bug insecticide products between 1999 and 2021. This study followed cases over 2007–2021, with a notable surge in reports of adverse reactions from 2016 onwards. Data revealed an increased recurrent misuse of insecticides, including substances banned or not approved for this use. Our findings underscore the growing public reliance on chemical insecticides for home bed bug management. With this is the concern of increased poisoning risks, and potential long-term health consequences from non-professional efforts by the public to manage bed bugs in their homes. This escalating trend emphasizes the need for safer and more sustainable pest management strategies in urban environments. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Aging phenotypes in cultured normal human mammary epithelial cells are correlated with decreased telomerase activity independent of telomere length

Author

Sputova, Klara, Garbe, James C, Pelissier, Fanny A, Chang, Eric, Stampfer, Martha R, and LaBarge, Mark A

Abstract

Abstract Background Shortening of telomeres, which are essential for maintenance of genomic integrity, is a mechanism commonly associated with the aging process. Here we ascertained whether changes in telomere lengths or telomerase activity correlated with age in normal human mammary epithelial cells (HMEC), or with phenotypes of aging in breast. Accordingly, flow cytometry fluorescence in situ hybridization (flowFISH) was used to determine relative telomere lengths (RTL), and telomerase activity was measured by the telomeric repeat amplification protocol (TRAP), in a collection of 41 primary HMEC strains established from women aged 16 to 91 years. Results RTL measurements of HMEC strains that were heterogeneous with respect to lineage composition revealed no significant associations between telomere length with age, maximum observed population doublings, or with lineage composition of the strains. However, within strains, luminal epithelial and cKit-expressing epithelial progenitor cells that were flow cytometry-enriched from individual HMEC strains exhibited significantly shorter telomeres relative to isogenic myoepithelial cells (P

Published
2013

6. Pre-hospital triage of children at risk of oesophageal button battery impaction: the button battery impaction score.

Author

Vaucel, Jules-Antoine, Gil-Jardine, Cédric, Paradis, Camille, Enaud, Raphael, Labadie, Magali, Deguigne, Marie, Le Roux, Gaël, Descatha, Alexis, Azzouz, Ramy, Nisse, Patrick, Patat, Anne-Marie, Paret, Nathalie, Blanc-Brisset, Ingrid, Nardon, Audrey, Courtois, Arnaud, de Haro, Luc, Simon, Nicolas, Delcourt, Nicolas, Pelissier, Fanny, and Tournoud, Christine

Subjects
BATTERY storage plants, ESOPHAGEAL perforation, MEDICAL triage, RAPID tooling, JOB descriptions, HEALTH facilities
Abstract

Button battery ingestion in children can be fatal if oesophageal perforation occurs. Such children require chest radiography in the emergency department to determine the button battery position and number. Current guidelines recommend that a button battery impacted in the oesophagus should be removed within two hours. We developed a clinical tool (the button battery impaction score) to estimate the risk of oesophageal impaction and help determine the most appropriate healthcare facility for initial assessment, either a local medical centre or a medical centre with the infrastructure for endoscopic retrieval. A multi-centre retrospective study was conducted over seven years in eight French poison centres. We included patients aged less than 12 years with radiography showing the button battery position and a symptom description before radiography. Button battery impaction scores were calculated using backward stepwise selection. A total of 1,430 patients were included, of whom 86, 461, and 375 had a button battery in their oesophagus, stomach, and post-pyloric position, respectively. No button batteries were identified by radiography in 508 patients. Sixteen of thirty-five factors independently predicted oesophageal impaction before chest radiography (P < 0.05). After the backward stepwise selection, the following seven factors contributed to the button battery impaction score: cough, drooling, dysphagia/food refusal, fever, pain (unspecified location), vomiting, and button battery ≥ 15 mm. The button battery impaction score showed an area under the curve value of 0.87, a negative predictive value of 0.98, and a sensitivity of 0.86. No cases of death, stricture, or haemorrhage were observed in patients with negative scores, including those with oesophageal impaction. A button battery impaction score used readily available data to predict the risk of oesophageal impaction after button battery ingestion and before chest radiography. When further validated, this rapid tool may be widely applicable in determining an appropriate facility for patient transfer to either a local medical centre or a medical centre with the infrastructure for endoscopic retrieval. [ABSTRACT FROM AUTHOR]

Published
2023
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7. sSupplementary Figure Legends 1-3 from Accumulation of Multipotent Progenitors with a Basal Differentiation Bias during Aging of Human Mammary Epithelia

Author

Garbe, James C., primary, Pepin, Francois, primary, Pelissier, Fanny A., primary, Sputova, Klara, primary, Fridriksdottir, Agla J., primary, Guo, Diana E., primary, Villadsen, Rene, primary, Park, Morag, primary, Petersen, Ole W., primary, Borowsky, Alexander D., primary, Stampfer, Martha R., primary, and LaBarge, Mark A., primary

Published
2023
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8. Data from Accumulation of Multipotent Progenitors with a Basal Differentiation Bias during Aging of Human Mammary Epithelia

Author

Garbe, James C., primary, Pepin, Francois, primary, Pelissier, Fanny A., primary, Sputova, Klara, primary, Fridriksdottir, Agla J., primary, Guo, Diana E., primary, Villadsen, Rene, primary, Park, Morag, primary, Petersen, Ole W., primary, Borowsky, Alexander D., primary, Stampfer, Martha R., primary, and LaBarge, Mark A., primary

Published
2023
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9. Supplementary Figure 1 from Accumulation of Multipotent Progenitors with a Basal Differentiation Bias during Aging of Human Mammary Epithelia

Author

Garbe, James C., primary, Pepin, Francois, primary, Pelissier, Fanny A., primary, Sputova, Klara, primary, Fridriksdottir, Agla J., primary, Guo, Diana E., primary, Villadsen, Rene, primary, Park, Morag, primary, Petersen, Ole W., primary, Borowsky, Alexander D., primary, Stampfer, Martha R., primary, and LaBarge, Mark A., primary

Published
2023
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10. Supplementary Figure 3 from Accumulation of Multipotent Progenitors with a Basal Differentiation Bias during Aging of Human Mammary Epithelia

Author

Garbe, James C., primary, Pepin, Francois, primary, Pelissier, Fanny A., primary, Sputova, Klara, primary, Fridriksdottir, Agla J., primary, Guo, Diana E., primary, Villadsen, Rene, primary, Park, Morag, primary, Petersen, Ole W., primary, Borowsky, Alexander D., primary, Stampfer, Martha R., primary, and LaBarge, Mark A., primary

Published
2023
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11. Supplementary Figure 2 from Accumulation of Multipotent Progenitors with a Basal Differentiation Bias during Aging of Human Mammary Epithelia

Author

Garbe, James C., primary, Pepin, Francois, primary, Pelissier, Fanny A., primary, Sputova, Klara, primary, Fridriksdottir, Agla J., primary, Guo, Diana E., primary, Villadsen, Rene, primary, Park, Morag, primary, Petersen, Ole W., primary, Borowsky, Alexander D., primary, Stampfer, Martha R., primary, and LaBarge, Mark A., primary

Published
2023
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14. Intoxications par l’hexahydrocannabinol : données des centres antipoison français 2021–2023

Author

Labadie, Magali, Nardon, Audrey, Schmitt, Corine, Paret, Nathalie, Chevalier, Cécile, Puskarczyk, Emmanuel, Nisse, Patrick, Descatha, Alexis, Langrand, Jérôme, Pelissier, Fanny, Paradis, Camille, Daveluy, Amélie, Guyon, Joris, Castaing, Nadège, Balkhi, Souleiman El, Saint-Marcoux, Franck, Grenouillet, Marike, Gaulier, Jean-Michel, and Tournoud, Christine

Published
2023
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17. Baclofen for the treatment of alcohol use disorder: the Cagliari Statement

Author

Agabio, Roberta, Sinclair, Julia MA, Addolorato, Giovanni, Aubin, Henri-Jean, Beraha, Esther M, Caputo, Fabio, Chick, Jonathan D, de La Selle, Patrick, Franchitto, Nicolas, Garbutt, James C, Haber, Paul S, Heydtmann, Mathis, Jaury, Philippe, Lingford-Hughes, Anne R, Morley, Kirsten C, Müller, Christian A, Owens, Lynn, Pastor, Adam, Paterson, Louise M, Pélissier, Fanny, Rolland, Benjamin, Stafford, Amanda, Thompson, Andrew, van den Brink, Wim, de Beaurepaire, Renaud, and Leggio, Lorenzo

Published
2018
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21. The Role of Age in Cellular Responses to Microenvironmental Cues as a Breast Cancer Susceptibility Factor

Author

Pelissier, Fanny

Abstract

Aging is the critical risk factor for many forms of cancer. We used the mammary gland as a model system to study the impact of age on human epithelia in which age is the greatest risk factor for cancer. Dysfunctional progenitor and luminal cells with acquired basal cell properties accumulate during aging for reasons that are not understood. We evaluated the hypothesis that a novel effect of aging is a defective stem cell regulation by the microenvironment. We identified Axl as a previously unappreciated mammary stem cell marker involved in breast epithelial homeostasis and breast cancer progression. We showed that Axl is a marker of a subpopulation of cKit epithelial progenitors. These progenitors are tightly regulated by the microenvironment, specifically the mechanical properties of the niche. We observed that mechano-response mechanisms in cKit progenitors are altered with age. Thus, tissue-level phenotypes of aging in breast may arise in part due to alterations in the Hippo mechano-signal transduction pathway that lead to reduced efficiency of YAP/TAZ activation. Finally, using mass cytometry, we described the first high-dimensional phenotypic heterogeneity in normal human mammary epithelial cells. Computational analysis using unsupervised population partitioning identified clusters of a specific subset of luminal cells that acquired a more basal phenotype and accumulate with age. Moreover, distinct age-related phenotypic signatures were detectable in cKit-progenitor cells, considered the cell-of-origin for breast cancers. Here, we propose a model where reciprocal interactions between the microenvironment and breast epithelial progenitors are skewed during the aging process, leading to a decrease in breast tissue integrity, and increase in phenotypic divergence and susceptibility to tumorigenesis.

Published
2016

24. Mise en place d’une politique publique de réduction des usages de pesticides : le plan Ecophyto

Author

Gary , Christian, Munier-Jolain , Nathalie, Pelissier , Fanny, Gaunand , Ariane, Colinet , Laurence, Département EA , ., ASIRPA (Analyse Socio‐économique des Impacts de la Recherche Publique Agronomique) , ., Fonctionnement et conduite des systèmes de culture tropicaux et méditerranéens (UMR SYSTEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Centre International de Hautes Etudes Agronomiques Méditerranéennes - Institut Agronomique Méditerranéen de Montpellier (CIHEAM-IAMM), Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Agroécologie [Dijon], Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, ACTALIA [Villers-Bocage], Délégation à l'évaluation, Institut National de la Recherche Agronomique (INRA), Collège de Direction (CODIR), Département Environnement et Agronomie (DEPT EA), auto-saisine, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Centre International de Hautes Etudes Agronomiques Méditerranéennes - Institut Agronomique Méditerranéen de Montpellier (CIHEAM-IAMM), Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université Bourgogne Franche-Comté [COMUE] (UBFC), Collège de Direction, Département Environnement et Agronomie (DPT_EA), Fonctionnement et conduite des systèmes de culture tropicaux et méditerranéens ( SYSTEM ), Centre de Coopération Internationale en Recherche Agronomique pour le Développement ( CIRAD ) -Institut National de la Recherche Agronomique ( INRA ) -Centre international d'études supérieures en sciences agronomiques ( Montpellier SupAgro ) -Institut national d’études supérieures agronomiques de Montpellier ( Montpellier SupAgro ), Institut National de la Recherche Agronomique ( INRA ) -Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université Bourgogne Franche-Comté ( UBFC ), Institut National de la Recherche Agronomique ( INRA ), and Département Environnement et Agronomie ( DPT_EA )

Subjects
[ SDV ] Life Sciences [q-bio], reduction of pollution, lutte contre la pollution, public policy, [SDV]Life Sciences [q-bio], impact sur l'environnement, politique publique, pesticide
Abstract

Le recours aux pesticides a des conséquences environnementales et sanitaires préoccupantes et différentes politiques publiques ont été élaborées pour le réduire. La question de l'utilisation des pesticides constitue entre 2003 et 2010 à la fois un problème de société important (problem stream), un enjeu en termes de politique sectorielle (policy stream) et une problématique importante pour l'environnement, sujet qui se trouve placé au cœur d’un débat national stimulé par la tenue du Grenelle de l’Environnement (political stream). Dans ce contexte, l’étude Ecophyto R&D, réalisée par l’INRA, a identifié les marges de manœuvre de réduction de pesticides dans différentes filières de production végétale. Appuyé sur une plateforme d'expérimentation, de démonstration et d’acquisition de références (DEPHY EXPE) et sur un réseau d’agriculteurs (DEPHY FERME), Ecopyhto R&D trouve des prolongements dans des actions qui appuient la mise en œuvre du plan Ecophyto.

Published
2014

25. Mise en place d’une politique publique de réduction des usages de pesticides : le plan Ecophyto

Author

Gary, Christian, Munier Jolain, Nathalie, Pelissier, Fanny, Gaunand, Ariane, Colinet, Laurence, and Institut National de Recherche Agronomique UAR 1155 Département Environnement et Agronomie

Subjects
lutte contre la pollution, impact sur l'environnement, politique publique, pesticide
Abstract

Le recours aux pesticides a des conséquences environnementales et sanitaires préoccupantes et différentes politiques publiques ont été élaborées pour le réduire. La question de l'utilisation des pesticides constitue entre 2003 et 2010 à la fois un problème de société important (problem stream), un enjeu en termes de politique sectorielle (policy stream) et une problématique importante pour l'environnement, sujet qui se trouve placé au cœur d’un débat national stimulé par la tenue du Grenelle de l’Environnement (political stream). Dans ce contexte, l’étude Ecophyto R&D, réalisée par l’INRA, a identifié les marges de manœuvre de réduction de pesticides dans différentes filières de production végétale. Appuyé sur une plateforme d'expérimentation, de démonstration et d’acquisition de références (DEPHY EXPE) et sur un réseau d’agriculteurs (DEPHY FERME), Ecopyhto R&D trouve des prolongements dans des actions qui appuient la mise en œuvre du plan Ecophyto.

Published
2014

26. Evaluation of the Possible Impact of Care Network for Stroke and Transient Ischemic Attack on Rates of Recurrence

Author

Raffe , Florie, Jacquin , Agnès, Milleret , Olivier, Durier , Jérôme, SAUZE , Damien, Peyron , Christine, Osseby , Guy-Victor, Menassa , Mickael, Hervieu , Marie, Pelissier , Fanny, Routhier , Pierre, Giroud , Maurice, Bejot , Yannick, Centre d'épidémiologie des populations ( CEP ), Université de Bourgogne ( UB ) -Centre Régional de Lutte contre le cancer - Centre Georges-François Leclerc ( CRLCC - CGFL ), Laboratoire d'Economie et de Gestion ( LEG ), Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] ( CAPS ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Comité français d'histoire de la géologie ( COFRHIGEO ), Neurology, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon), Centre d'épidémiologie des populations (CEP), Université de Bourgogne (UB)-Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER, Laboratoire d'Economie et de Gestion (LEG), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] (CAPS), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), Comité français d'histoire de la géologie (COFRHIGEO), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), and PRZEDWOJ, VALERIE

Subjects
Stroke, Ischemic Attack, [ SHS.ECO ] Humanities and Social Sciences/Economies and finances, Impact of care network, [SHS.ECO] Humanities and Social Sciences/Economics and Finance, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2011

29. Accumulation of multipotent progenitors with a basal differentiation bias during aging of human mammary epithelia

Author

Garbe, James C, Pepin, Francois, Pelissier, Fanny A, Sputova, Klara, Fridriksdottir, Agla J, Guo, Diana E, Villadsen, Rene, Park, Morag, Petersen, Ole W, Borowsky, Alexander D, Stampfer, Martha R, Labarge, Mark A, Garbe, James C, Pepin, Francois, Pelissier, Fanny A, Sputova, Klara, Fridriksdottir, Agla J, Guo, Diana E, Villadsen, Rene, Park, Morag, Petersen, Ole W, Borowsky, Alexander D, Stampfer, Martha R, and Labarge, Mark A

Abstract

Women older than 50 years account for 75% of new breast cancer diagnoses, and the majority of these tumors are of a luminal subtype. Although age-associated changes, including endocrine profiles and alterations within the breast microenvironment, increase cancer risk, an understanding of the cellular and molecular mechanisms that underlies these observations is lacking. In this study, we generated a large collection of normal human mammary epithelial cell strains from women ages 16 to 91 years, derived from primary tissues, to investigate the molecular changes that occur in aging breast cells. We found that in finite lifespan cultured and uncultured epithelial cells, aging is associated with a reduction of myoepithelial cells and an increase in luminal cells that express keratin 14 and integrin-a6, a phenotype that is usually expressed exclusively in myoepithelial cells in women younger than 30 years. Changes to the luminal lineage resulted from age-dependent expansion of defective multipotent progenitors that gave rise to incompletely differentiated luminal or myoepithelial cells. The aging process therefore results in both a shift in the balance of luminal/myoepithelial lineages and to changes in the functional spectrum of multipotent progenitors, which together increase the potential for malignant transformation. Together, our findings provide a cellular basis to explain the observed vulnerability to breast cancer that increases with age.

Published
2012

32. Abstract 4888: Axl receptor signaling in required for stem cell traits and metastasis in breast cancer.

Author

Tiron, Crina, primary, Pelissier, Fanny, additional, Wnuk-Lipinska, Katarzyna, additional, Stefansson, Ingunn, additional, Virtakoivu, Reeta, additional, Miyano, Masaru, additional, Sandal, Tone, additional, Micklem, David, additional, Garbe, James, additional, Stampfer, Martha, additional, Ivaska, Johanna, additional, Akslen, Lars, additional, LaBarge, Mark, additional, and Lorens, James, additional

Published
2013
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33. Abstract C76: Axl signaling is required for stem cell traits and metastasis in breast cancer

Author

Tiron, Crina, primary, Pelissier, Fanny, additional, Wnuk-Lipinska, Katarzyna, additional, Stefansson, Ingunn, additional, Virtakoivu, Reeta, additional, Miyano, Masaru, additional, Sandal, Tone, additional, Micklem, David, additional, Garbe, James, additional, Stampfer, Martha, additional, Ivaska, Johanna, additional, Akslen, Lars, additional, LaBarge, Mark, additional, and Lorens, James, additional

Published
2013
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34. Accumulation of Multipotent Progenitors with a Basal Differentiation Bias during Aging of Human Mammary Epithelia

Author

Garbe, James C., primary, Pepin, Francois, additional, Pelissier, Fanny A., additional, Sputova, Klara, additional, Fridriksdottir, Agla J., additional, Guo, Diana E., additional, Villadsen, Rene, additional, Park, Morag, additional, Petersen, Ole W., additional, Borowsky, Alexander D., additional, Stampfer, Martha R., additional, and LaBarge, Mark A., additional

Published
2012
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35. Evaluation of the Possible Impact of a Care Network for Stroke and Transient Ischemic Attack on Rates of Recurrence

Author

Raffe, Florie, primary, Jacquin, Agnès, additional, Milleret, Olivier, additional, Durier, Jérôme, additional, Sauze, Damien, additional, Peyron, Christine, additional, Osseby, Guy Victor, additional, Menassa, Michaël, additional, Hervieu, Marie, additional, Pelissier, Fanny, additional, Routhier, Pierre, additional, Beis, Jean-Noel, additional, Giroud, Maurice, additional, and Béjot, Yannick, additional

Published
2011
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36. Le bebop et Charlie Parker

Author

PELISSIER, Fanny, BELLONI, Federico, STAROBINSKI, Georges, and GIARDINA, Adriano

Subjects
Création musicale et biographie, Arts et esthétique, Sections SV, STI

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