214 results on '"Pelchen-Matthews, Annegret"'
Search Results
2. Heavy antiretroviral exposure and exhausted/limited antiretroviral options: predictors and clinical outcomes
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Mocroft, Amanda, Pelchen-Matthews, Annegret, Hoy, Jennifer, Llibre, Josep M., Neesgaard, Bastian, Jaschinski, Nadine, Domingo, Pere, Rasmussen, Line Dahlerup, Günthard, Huldrych F., Surial, Bernard, Öllinger, Angela, Knappik, Michael, de Wit, Stephane, Wit, Ferdinand, Mussini, Cristina, Vehreschild, Joerg, Monforte, Antonella D’Arminio, Sonnerborg, Anders, Castagna, Antonella, Anne, Alain Volny, Vannappagari, Vani, Cohen, Cal, Greaves, Wayne, Wasmuth, Jan C., Spagnuolo, Vincenzo, and Ryom, Lene
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- 2024
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3. Associations between integrase strand-transfer inhibitors and cardiovascular disease in people living with HIV: a multicentre prospective study from the RESPOND cohort consortium
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Neesgaard, Bastian, Greenberg, Lauren, Miró, Jose M, Grabmeier-Pfistershammer, Katharina, Wandeler, Gilles, Smith, Colette, De Wit, Stéphane, Wit, Ferdinand, Pelchen-Matthews, Annegret, Mussini, Cristina, Castagna, Antonella, Pradier, Christian, d'Arminio Monforte, Antonella, Vehreschild, Jörg J, Sönnerborg, Anders, Anne, Alain V, Carr, Andrew, Bansi-Matharu, Loveleen, Lundgren, Jens D, Garges, Harmony, Rogatto, Felipe, Zangerle, Robert, Günthard, Huldrych F, Rasmussen, Line D, Necsoi, Coca, van der Valk, Marc, Menozzi, Marianna, Muccini, Camilla, Peters, Lars, Mocroft, Amanda, and Ryom, Lene
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- 2022
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4. Observational cohort study of rilpivirine (RPV) utilization in Europe
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Cozzi-Lepri, Alessandro, Peters, Lars, Pelchen-Matthews, Annegret, Neesgaard, Bastian, De Wit, Stephane, Johansen, Isik Somuncu, Edwards, Simon, Stephan, Christoph, Adamis, Georgios, Staub, Therese, Zagalo, Alexandra, Domingo, Pere, Elbirt, Daniel, Kusejko, Katharina, Brännström, Johanna, Paduta, Dzmitry, Trofimova, Tatyana, Szlavik, Janos, Zilmer, Kai, Losso, Marcello, Van Eygen, Veerle, Pai, Helen, Lundgren, Jens, and Mocroft, Amanda
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- 2022
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5. Rapid formation of human immunodeficiency virus-like particles
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Bednarska, Joanna, Pelchen-Matthews, Annegret, Novak, Pavel, Burden, Jemima J., Summers, Peter A., Kuimova, Marina K., Korchev, Yuri, Marsh, Mark, and Shevchuk, Andrew
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- 2020
6. Trends in Mortality in People With HIV From 1999 through 2020: A Multicohort Collaboration.
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Tusch, Erich, Ryom, Lene, Pelchen-Matthews, Annegret, Mocroft, Amanda, Elbirt, Daniel, Oprea, Cristiana, Günthard, Huldrych F, Staehelin, Cornelia, Zangerle, Robert, Suarez, Isabelle, Vehreschild, Jörg Janne, Wit, Ferdinand, Menozzi, Marianna, Monforte, Antonella d'Arminio, Spagnuolo, Vincenzo, Pradier, Christian, Carlander, Christina, Suanzes, Paula, Wasmuth, Jan-Christian, and Carr, Andrew
- Subjects
HIV infection risk factors ,MORTALITY ,RISK assessment ,POISSON distribution ,VIROLOGY ,SECONDARY analysis ,RESEARCH funding ,HIV-positive persons ,HIV infections ,CAUSES of death ,DESCRIPTIVE statistics ,MULTIVARIATE analysis ,CONFIDENCE intervals ,TUMORS ,AIDS - Abstract
Background Mortality among people with human immunodeficiency virus (HIV) declined with the introduction of combination antiretroviral therapy. We investigated trends in mortality in people with HIV from 1999 through 2020. Methods Data were collected from the Data Collection on Adverse events of Anti-HIV Drugs (D:A:D) cohort between January 1999 through January 2015 and the International Cohort Consortium of Infectious Disease (RESPOND) from October 2017 through December 2020. Age-standardized all-cause and cause-specific mortality rates, classified using Coding Causes of Death in HIV, were calculated. Poisson models were used to assess mortality over time. Results Among 55 716 participants followed for median 6 years (interquartile range, 3–11), 5263 died (mortality rate [MR], 13.7/1000 person-years of follow-up [PYFU]; 95% confidence interval [CI], 13.4–14.1). Changing mortality was observed: AIDS mortality was most common between 1999–2009 (n = 952; MR, 4.2/1000 PYFU; 95% CI, 4.0–4.5) and non-AIDS–defining malignancy (NADM) between 2010–2020 (n = 444; MR, 2.8/1000 PYFU; 95% CI, 2.5–3.1). In multivariable analysis, all-cause mortality declined (adjusted mortality rate ratio [aMRR], 0.97 per year; 95% CI,.96–.98), mostly 1999–2010 (aMRR, 0.96 per year; 95% CI,.95–.97) but was stable 2011–2020 (aMRR, 1.00 per year; 95% CI,.96–1.05). Mortality due to all known causes except NADM also declined. Conclusions Mortality among people with HIV in the D:A:D and/or RESPOND cohorts declined between 1999–2009 and was stable over the period 2010–2020. This decline in mortality was not fully explained by improvements in immunologic–virologic status or other risk factors. [ABSTRACT FROM AUTHOR]
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- 2024
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7. Positive Voices 2022: Methodology and recruitment of a national survey of people with HIV and accessing care in England, Wales, and Scotland (Preprint)
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Sewell, Janey, primary, Kelly, Carole, additional, Aghaizu, Adamma, additional, Martin, Veronique, additional, Farah, Amal, additional, Smith, Colette, additional, Brown, Alison, additional, Humphreys, Clare, additional, Sparrowhawk, Alex, additional, Kitt, Hannah, additional, Delpech, Valerie, additional, Pelchen-Matthews, Annegret, additional, Rodger, Alison, additional, Lampe, Fiona, additional, and Kall, Meaghan, additional
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- 2024
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8. Trends in mortality in people with HIV from 1999 to 2020: a multi-cohort collaboration
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Tusch, E, Ryom, L, Pelchen-Matthews, A, Mocroft, A, Elbirt, D, Oprea, C, Günthard, H, Staehelin, C, Zangerle, R, Suarez, I, Vehreschild, J, Wit, F, Menozzi, M, d'Arminio Monforte, A, Spagnuolo, V, Pradier, C, Carlander, C, Suanzes, P, Wasmuth, J, Carr, A, Petoumenos, K, Borgans, F, Bonnet, F, De Wit, S, El-Sadr, W, Neesgaard, B, Jaschinski, N, Greenberg, L, Hosein, S, Gallant, J, Vannappagari, V, Young, L, Sabin, C, Lundgren, J, Peters, L, Reekie, J, Calvo, G, Dabis, F, Kirk, O, Law, M, Monforte, A, Morfeldt, L, Reiss, P, Weber, R, Lind-Thomsen, A, Brandt, R, Hillebreght, M, Zaheri, S, Scherrer, A, Schöni-Affolter, F, Rickenbach, M, Tavelli, A, Fanti, I, Leleux, O, Mourali, J, Marec, F, Boerg, E, Thulin, E, Sundström, A, Bartsch, G, Thompsen, G, Necsoi, C, Delforge, M, Fontas, E, Caissotti, C, Dollet, K, Mateu, S, Torres, F, Blance, A, Huang, R, Puhr, R, Laut, K, Kristensen, D, Phillips, A, Kamara, D, Smith, C, Hatleberg, C, Raben, D, Matthews, C, Bojesen, A, Grevsen, A, Powderly, B, Shortman, N, Moecklinghoff, C, Reilly, G, Franquet, X, Smit, C, Ross, M, Fux, C, Morlat, P, Friis-Møller, N, Kowalska, J, Bohlius, J, Bower, M, Fätkenheuer, G, Grulich, A, Sjøl, A, Meidahl, P, Iversen, J, Reiss, C, Hillebregt, M, Prins, J, Kuijpers, T, Scherpbier, H, van der Meer, J, Godfried, M, van der Poll, T, Nellen, F, Geerlings, S, van Vugt, M, Pajkrt, D, Bos, J, Wiersinga, W, van der Valk, M, Goorhuis, A, Hovius, J, van Eden, J, Henderiks, A, van Hes, A, Mutschelknauss, M, Nobel, H, Pijnappel, F, Jurriaans, S, Back, N, Zaaijer, H, Berkhout, B, Cornelissen, M, Schinkel, C, Thomas, X, Ziekenhuis, A, van den Berge, M, Stegeman, A, Baas, S, de Looff, L, Versteeg, D, Ziekenhuis, C, Pronk, M, Ammerlaan, H, De Munnik, E, Jansz, A, Tjhie, J, Wegdam, M, Deiman, B, Scharnhorst, V, van der Plas, A, Weijsenfeld, A, van der Ende, M, De Vries-Sluijs, T, van Gorp, E, Schurink, C, Nouwen, J, Verbon, A, Rijnders, B, Bax, H, van der Feltz, M, Bassant, N, van Beek, J, Vriesde, M, van Zonneveld, L, de Oude-Lubbers, A, van den Berg-Cameron, H, Bruinsma-Broekman, F, de Groot, J, de Man, M, Boucher, C, Koopmans, M, van Kampen, J, Pas, S, Mc–sophia, E, Driessen, G, van Rossum, A, van der Knaap, L, Visser, E, Branger, J, Rijkeboer-Mes, A, de Ven, C, Ziekenhuis, H, Schippers, E, van Nieuwkoop, C, van IJperen, J, Geilings, J, van der Hut, G, Franck, P, van Eeden, A, Brokking, W, Groot, M, Elsenburg, L, Damen, M, Kwa, I, Groeneveld, P, Bouwhuis, J, van den Berg, J, van Hulzen, A, van der Bliek, G, Bor, P, Bloembergen, P, Wolfhagen, M, Ruijs, G, Kroon, F, de Boer, M, Bauer, M, Jolink, H, Vollaard, A, Dorama, W, van Holten, N, Claas, E, Wessels, E, den Hollander, J, Pogany, K, Roukens, A, Kastelijns, M, Smit, J, Smit, E, Struik-Kalkman, D, Tearno, C, Bezemer, M, van Niekerk, T, Pontesilli, O, Lowe, S, Lashof, A, Posthouwer, D, Ackens, R, Schippers, J, Vergoossen, R, Weijenberg-Maes, B, van Loo, I, Havenith, T, Leyten, E, Gelinck, L, van Hartingsveld, A, Meerkerk, C, Wildenbeest, G, Mutsaers, J, Jansen, C, Mulder, J, Vrouenraets, S, Lauw, F, van Broekhuizen, M, Paap, H, Vlasblom, D, Smits, P, Zuiderzee, M, Weijer, S, El Moussaoui, R, Bosma, A, van Vonderen, M, van Houte, D, Kampschreur, L, Dijkstra, K, Faber, S, Weel, J, Kootstra, G, Delsing, C, van der Burg-van de Plas, M, Heins, H, Lucas, E, Kortmann, W, van Twillert, G, Stuart, J, Diederen, B, Pronk, D, van Truijen-Oud, F, van der Reijden, W, Jansen, R, Brinkman, K, van den Berk, G, Blok, W, Frissen, P, Lettinga, K, Schouten, W, Veenstra, J, Brouwer, C, Geerders, G, Hoeksema, K, Kleene, M, van der Meché, I, Spelbrink, M, Sulman, H, Toonen, A, Wijnands, S, Kwa, D, Witte, E, Koopmans, P, Keuter, M, van der Ven, A, ter Hofstede, H, Dofferhoff, A, van Crevel, R, Albers, M, Bosch, M, Grintjes-Huisman, K, Zomer, B, Stelma, F, Rahamat-Langendoen, J, Burger, D, Richter, C, Gisolf, E, Hassing, R, ter Beest, G, van Bentum, P, Langebeek, N, Tiemessen, R, Swanink, C, van Lelyveld, S, Soetekouw, R, Hulshoff, N, van der Prijt, L, van der Swaluw, J, Bermon, N, Herpers, B, Veenendaal, D, Verhagen, D, van Wijk, M, Ziekenhuis, S, van Kasteren, M, Brouwer, A, de Wiel, B, Kuipers, M, Santegoets, R, van der Ven, B, Marcelis, J, Buiting, A, Kabel, P, Bierman, W, Scholvinck, H, Wilting, K, Stienstra, Y, Jonge, H, van der Meulen, P, de Weerd, D, Ludwig-Roukema, J, Niesters, H, Riezebos-Brilman, A, van Leer-Buter, C, Knoester, M, Hoepelman, A, Mudrikova, T, Ellerbroek, P, Oosterheert, J, Arends, J, Barth, R, Wassenberg, M, Schadd, E, van Elst-Laurijssen, D, van Oers-Hazelzet, E, Vervoort, S, van Berkel, M, Schuurman, R, Verduyn-Lunel, F, Wensing, A, Peters, E, van Agtmael, M, Bomers, M, de Vocht, J, Heitmuller, M, Laan, L, Pettersson, A, Vandenbroucke-Grauls, C, Ang, C, Kinderziekenhuis, W, Geelen, S, Wolfs, T, Bont, L, Nauta, N, Bezemer, D, van Sighem, A, Boender, T, de Jong, A, Bergsma, D, Hoekstra, P, de Lang, A, Grivell, S, Jansen, A, Rademaker, M, Raethke, M, Meijering, R, Schnörr, S, de Groot, L, van den Akker, M, Bakker, Y, Claessen, E, El Berkaoui, A, Koops, J, Kruijne, E, Lodewijk, C, Munjishvili, L, Peeck, B, Ree, C, Regtop, R, Ruijs, Y, Rutkens, T, van de Sande, L, Schoorl, M, Timmerman, A, Tuijn, E, Veenenberg, L, van der Vliet, S, Wisse, A, Woudstra, T, Tuk, B, Dupon, M, Gaborieau, V, Lacoste, D, Malvy, D, Mercié, P, Neau, D, Pellegrin, J, Tchamgoué, S, Lazaro, E, Cazanave, C, Vandenhende, M, Vareil, M, Gérard, Y, Blanco, P, Bouchet, S, Breilh, D, Fleury, H, Pellegrin, I, Chêne, G, Thiébaut, R, Wittkop, L, Lawson-Ayayi, S, Gimbert, A, Desjardin, S, Lacaze-Buzy, L, Petrov-Sanchez, V, André, K, Bernard, N, Caubet, O, Caunegre, L, Chossat, I, Courtault, C, Dauchy, F, De Witte, S, Dondia, D, Duffau, P, Dutronc, H, Farbos, S, Faure, I, Ferrand, H, Gerard, Y, Greib, C, Hessamfar, M, Imbert, Y, Lataste, P, Marie, J, Mechain, M, Monlun, E, Ochoa, A, Pistone, T, Raymond, I, Receveur, M, Rispal, P, Sorin, L, Valette, C, Viallard, J, Wille, H, Wirth, G, Lafon, M, Trimoulet, P, Bellecave, P, Tumiotto, C, Haramburu, F, Miremeont-Salamé, G, Blaizeau, M, Decoin, M, Hannapier, C, Lenaud, E, Pougetoux, A, Delveaux, S, D’Ivernois, C, Diarra, F, Uwamaliya-Nziyumvira, B, Palmer, G, Conte, V, Sapparrart, V, Law, C, Moore, R, Edwards, S, Hoy, J, Watson, K, Roth, N, Lau, H, Bloch, M, Baker, D, Cooper, D, O’Sullivan, M, Nolan, D, Guelfi, G, Calvo, C, Domingo, P, Sambeat, M, Gatell, J, Del Cacho, E, Cadafalch, J, Fuster, M, Codina, C, Sirera, G, Vaqué, A, Clumeck, N, Gennotte, A, Gerard, M, Kabeya, K, Konopnicki, D, Libois, A, Martin, C, Payen, M, Semaille, P, Van Laethem, Y, Neaton, C, Krum, E, Thompson, G, Wentworth, D, Luskin-Hawk, R, Telzak, E, Abrams, D, Cohn, D, Markowitz, N, Arduino, R, Mushatt, D, Friedland, G, Perez, G, Tedaldi, E, Fisher, E, Gordin, F, Crane, L, Sampson, J, Baxter, J, Gazzard, B, Horban, A, Karpov, I, Losso, M, Pedersen, C, Ristola, M, Rockstroh, J, Fischer, A, Larsen, J, Podlekareva, D, Cozzi-Lepri, A, Shepherd, L, Schultze, A, Amele, S, Kundro, M, Schmied, B, Wien, P, Vassilenko, A, Mitsura, V, Paduto, D, Florence, E, Vandekerckhove, L, Hadziosmanovic, V, Begovac, J, Machala, L, Jilich, D, Sedlacek, D, Kronborg, G, Benfield, T, Gerstoft, J, Katzenstein, T, Møller, N, Ostergaard, L, Wiese, L, Nielsen, L, Zilmer, K, Smidt, J, Siseklinik, N, Aho, I, Viard, J, Duvivier, C, Schmidt, R, Degen, O, Stellbrink, H, Stefan, C, Goethe, J, Bogner, J, Chkhartishvili, N, Gargalianos, P, Xylomenos, G, Armenis, K, Sambatakou, H, Szlávik, J, Gottfredsson, M, Mulcahy, F, Yust, I, Turner, D, Burke, M, Shahar, E, Hassoun, G, Elinav, H, Haouzi, M, Sthoeger, Z, Esposito, R, Mazeu, I, Mussini, C, Mazzotta, F, Gabbuti, A, Annunziata, O, Vullo, V, Lichtner, M, Zaccarelli, M, Antinori, A, Acinapura, R, Plazzi, M, Lazzarin, A, Castagna, A, Gianotti, N, Galli, M, Ridolfo, A, Rozentale, B, Uzdaviniene, V, Matulionyte, R, Staub, T, Hemmer, R, Ormaasen, V, Maeland, A, Bruun, J, Knysz, B, Gasiorowski, J, Inglot, M, Bakowska, E, Flisiak, R, Grzeszczuk, A, Parczewski, M, Maciejewska, K, Aksak-Was, B, Beniowski, M, Mularska, E, Smiatacz, T, Gensing, M, Jablonowska, E, Malolepsza, E, Wojcik, K, Mozer-Lisewska, I, Caldeira, L, Mansinho, K, Maltez, F, Radoi, R, Panteleev, A, Panteleev, O, Yakovlev, A, Trofimora, T, Khromova, I, Kuzovatova, E, Blokhina, I, Novogrod, N, Borodulina, E, Vdoushkina, E, Jevtovic, D, Tomazic, J, Miró, J, Moreno, S, Rodriguez, J, Clotet, B, Jou, A, Paredes, R, Tural, C, Puig, J, Bravo, I, Gutierrez, M, Mateo, G, Laporte, J, Sonnerborg, A, Brännström, I, Flamholc, L, Cavassini, M, Calmy, A, Furrer, H, Battegay, M, Schmid, P, Kuznetsova, A, Kyselyova, G, Sluzhynska, M, Johnson, A, Simons, E, Johnson, M, Orkin, C, Weber, J, Scullard, G, Clarke, A, Leen, C, Morfeldt, C, Thulin, G, Åkerlund, B, Koppel, K, Karlsson, A, Håkangård, C, Castelli, F, Cauda, R, Perri, G, Iardino, R, Ippolito, G, Marchetti, G, Perno, C, von Schloesser, F, Viale, P, Ceccherini-Silberstein, F, Girardi, E, Caputo, S, Puoti, M, Andreoni, M, Ammassari, A, Balotta, C, Bandera, A, Bonfanti, P, Bonora, S, Borderi, M, Calcagno, A, Calza, L, Capobianchi, M, Cingolani, A, Cinque, P, De Luca, A, Biagio, A, Gori, A, Guaraldi, G, Lapadula, G, Madeddu, G, Maggiolo, F, Marcotullio, S, Monno, L, Nozza, S, Roldan, E, Rossotti, R, Rusconi, S, Santoro, M, Saracino, A, Galli, L, Lorenzini, P, Rodano, A, Shanyinde, M, Carletti, F, Carrara, S, Caro, A, Graziano, S, Petrone, F, Prota, G, Quartu, S, Truffa, S, Giacometti, A, Costantini, A, Barocci, V, Angarano, G, Santoro, C, Suardi, C, Donati, V, Verucchi, G, Minardi, C, Quirino, T, Abeli, C, Manconi, P, Piano, P, Cacopardo, B, Celesia, B, Vecchiet, J, Falasca, K, Pan, A, Lorenzotti, S, Sighinolfi, L, Segala, D, Vichi, F, Cassola, G, Viscoli, C, Alessandrini, A, Bobbio, N, Mazzarello, G, Mastroianni, C, Belvisi, V, Caramma, I, Chiodera, A, Milini, P, Rizzardini, G, Moioli, M, Piolini, R, Salpietro, S, Tincati, C, Puzzolante, C, Abrescia, N, Chirianni, A, Borgia, G, Orlando, R, Bonadies, G, Martino, F, Gentile, I, Maddaloni, L, Cattelan, A, Marinello, S, Cascio, A, Colomba, C, Baldelli, F, Schiaroli, E, Parruti, G, Sozio, F, Magnani, G, Ursitti, M, Cristaudo, A, Baldin, G, Capozzi, M, Cicalini, S, Sulekova, L, Iaiani, G, Latini, A, Mastrorosa, I, Savinelli, S, Vergori, A, Cecchetto, M, Viviani, F, Bagella, P, Rossetti, B, Franco, A, Del Vecchio, R, Francisci, D, Giuli, C, Caramello, P, Orofino, G, Sciandra, M, Bassetti, M, Londero, A, Pellizzer, G, Manfrin, V, Starnini, G, Ialungo, A, Central, C, Dellamonica, P, Bernard, E, Courjon, J, Cua, E, De Salvador-Guillouet, F, Durant, J, Etienne, C, Ferrando, S, Mondain-Miton, V, Naqvi, A, Perbost, I, Pillet, S, Prouvost-Keller, B, Pugliese, P, Rio, V, Risso, K, Roger, P, Aubert, V, Bernasconi, E, Böni, J, Braun, D, Bucher, H, Ciuffi, A, Dollenmaier, G, Egger, M, Elzi, L, Fehr, J, Fellay, J, Haerry, D, Hasse, B, Hirsch, H, Hoffmann, M, Hösli, I, Kahlert, C, Kaiser, L, Keiser, O, Klimkait, T, Kouyos, R, Kovari, H, Ledergerber, B, Martinetti, G, de Tejada, B, Marzolini, C, Metzner, K, Müller, N, Nicca, D, Pantaleo, G, Paioni, P, Rauch, A, Rudin, C, Speck, R, Stöckle, M, Tarr, P, Trkola, A, Vernazza, P, Wandeler, G, Yerly, S, Valk, M, Hutchinson, J, Rupasinghe, D, Han, W, Appoyer, H, Vera, J, Broster, B, Barbour, L, Carney, D, Greenland, L, Coughlan, R, Saint-Pierre, C, Stephan, C, Bucht, M, Chokoshvili, O, Borghi, V, Casabona, J, Miro, J, Lampe, F, Burns, F, Chaloner, C, Muccini, C, Lolatto, R, Sönnerborg, A, Nowak, P, Vesterbacka, J, Mattsson, L, Carrick, D, Stigsäter, K, Kusejko, K, Schulze, N, Franke, B, Rooney, J, Mcnicholl, I, Garges, H, Campo, R, Volny-Anne, A, Dedes, N, Williams, E, Bruguera, A, Volny-Anne, R, Mendão, L, Timiryasova, A, Fursa, O, Jakobsen, M, Kraef, C, Gardizi, M, Andersen, K, Kumar, L, Elsing, T, Shahi, S, Valdenmaiier, O, Bansi-Matharu, L, Byonanebye, D, Bannister, W, Roen, A, Null, N, Tusch, Erich, Ryom, Lene, Pelchen-Matthews, Annegret, Mocroft, Amanda, Elbirt, Daniel, Oprea, Cristiana, Günthard, Huldrych F, Staehelin, Cornelia, Zangerle, Robert, Suarez, Isabelle, Vehreschild, Jörg Janne, Wit, Ferdinand, Menozzi, Marianna, d'Arminio Monforte, Antonella, Spagnuolo, Vincenzo, Pradier, Christian, Carlander, Christina, Suanzes, Paula, Wasmuth, Jan-Christian, Carr, Andrew, Petoumenos, Kathy, Borgans, Frauke, Bonnet, Fabrice, De Wit, Stephane, El-Sadr, Wafaa, Neesgaard, Bastian, Jaschinski, Nadine, Greenberg, Lauren, Hosein, Sean R, Gallant, Joel, Vannappagari, Vani, Young, Lital, Sabin, Caroline, Lundgren, Jens, Peters, Lars, Reekie, Joanne, Monforte, A d’Arminio, Brandt, R Salbøl, Wit, F W N M, Marec, F Le, Laut, K Grønborg, Sabin, C A, Phillips, A N, Kamara, D A, Smith, C J, Hatleberg, C I, Brandt, R S, Grevsen, A L, Lundgren, J D, Fux, C A, Monforte, A d'Arminio, Iversen, J S, Reiss, Central P, Prins, J M, Kuijpers, T W, Scherpbier, H J, van der Meer, J T M, Godfried, M H, Nellen, F J B, Geerlings, S E, Bos, J C, Wiersinga, W J, Hovius, J W, van Hes, A M H, 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Capobianchi, M, Cingolani, A, Cinque, P, De Luca, A, Biagio, A, Gori, A, Guaraldi, G, Lapadula, G, Madeddu, G, Maggiolo, F, Marcotullio, S, Monno, L, Nozza, S, Roldan, E, Rossotti, R, Rusconi, S, Santoro, M, Saracino, A, Galli, L, Lorenzini, P, Rodano, A, Shanyinde, M, Carletti, F, Carrara, S, Caro, A, Graziano, S, Petrone, F, Prota, G, Quartu, S, Truffa, S, Giacometti, A, Costantini, A, Barocci, V, Angarano, G, Santoro, C, Suardi, C, Donati, V, Verucchi, G, Minardi, C, Quirino, T, Abeli, C, Manconi, P, Piano, P, Cacopardo, B, Celesia, B, Vecchiet, J, Falasca, K, Pan, A, Lorenzotti, S, Sighinolfi, L, Segala, D, Vichi, F, Cassola, G, Viscoli, C, Alessandrini, A, Bobbio, N, Mazzarello, G, Mastroianni, C, Belvisi, V, Caramma, I, Chiodera, A, Milini, P, Rizzardini, G, Moioli, M, Piolini, R, Salpietro, S, Tincati, C, Puzzolante, C, Abrescia, N, Chirianni, A, Borgia, G, Orlando, R, Bonadies, G, Martino, F, Gentile, I, Maddaloni, L, Cattelan, A, Marinello, S, Cascio, A, Colomba, C, Baldelli, F, Schiaroli, E, Parruti, G, Sozio, F, Magnani, G, Ursitti, M, Cristaudo, A, Baldin, G, Capozzi, M, Cicalini, S, Sulekova, L, Iaiani, G, Latini, A, Mastrorosa, I, Savinelli, S, Vergori, A, Cecchetto, M, Viviani, F, Bagella, P, Rossetti, B, Franco, A, Del Vecchio, R, Francisci, D, Giuli, C, Caramello, P, Orofino, G, Sciandra, M, Bassetti, M, Londero, A, Pellizzer, G, Manfrin, V, Starnini, G, Ialungo, A, Central, C, Dellamonica, P, Bernard, E, Courjon, J, Cua, E, De Salvador-Guillouet, F, Durant, J, Etienne, C, Ferrando, S, Mondain-Miton, V, Naqvi, A, Perbost, I, Pillet, S, Prouvost-Keller, B, Pugliese, P, Rio, V, Risso, K, Roger, P, Aubert, V, Bernasconi, E, Böni, J, Braun, D, Bucher, H, Ciuffi, A, Dollenmaier, G, Egger, M, Elzi, L, Fehr, J, Fellay, J, Haerry, D, Hasse, B, Hirsch, H, Hoffmann, M, Hösli, I, Kahlert, C, Kaiser, L, Keiser, O, Klimkait, T, Kouyos, R, Kovari, H, Ledergerber, B, Martinetti, G, de Tejada, B, Marzolini, C, Metzner, K, Müller, N, Nicca, D, Pantaleo, G, Paioni, P, Rauch, A, Rudin, C, Speck, R, Stöckle, M, Tarr, P, Trkola, A, Vernazza, P, Wandeler, G, Yerly, S, Valk, M, Hutchinson, J, Rupasinghe, D, Han, W, Appoyer, H, Vera, J, Broster, B, Barbour, L, Carney, D, Greenland, L, Coughlan, R, Saint-Pierre, C, Stephan, C, Bucht, M, Chokoshvili, O, Borghi, V, Casabona, J, Miro, J, Lampe, F, Burns, F, Chaloner, C, Muccini, C, Lolatto, R, Sönnerborg, A, Nowak, P, Vesterbacka, J, Mattsson, L, Carrick, D, Stigsäter, K, Kusejko, K, Schulze, N, Franke, B, Rooney, J, Mcnicholl, I, Garges, H, Campo, R, Volny-Anne, A, Dedes, N, Williams, E, Bruguera, A, Volny-Anne, R, Mendão, L, Timiryasova, A, Fursa, O, Jakobsen, M, Kraef, C, Gardizi, M, Andersen, K, Kumar, L, Elsing, T, Shahi, S, Valdenmaiier, O, Bansi-Matharu, L, Byonanebye, D, Bannister, W, Roen, A, Null, N, Tusch, Erich, Ryom, Lene, Pelchen-Matthews, Annegret, Mocroft, Amanda, Elbirt, Daniel, Oprea, Cristiana, Günthard, Huldrych F, Staehelin, Cornelia, Zangerle, Robert, Suarez, Isabelle, Vehreschild, Jörg Janne, Wit, Ferdinand, Menozzi, Marianna, d'Arminio Monforte, Antonella, Spagnuolo, Vincenzo, Pradier, Christian, Carlander, Christina, Suanzes, Paula, Wasmuth, Jan-Christian, Carr, Andrew, Petoumenos, Kathy, Borgans, Frauke, Bonnet, Fabrice, De Wit, Stephane, El-Sadr, Wafaa, Neesgaard, Bastian, Jaschinski, Nadine, Greenberg, Lauren, Hosein, Sean R, Gallant, Joel, Vannappagari, Vani, Young, Lital, Sabin, Caroline, Lundgren, Jens, Peters, Lars, Reekie, Joanne, Monforte, A d’Arminio, Brandt, R Salbøl, Wit, F W N M, Marec, F Le, Laut, K Grønborg, Sabin, C A, Phillips, A N, Kamara, D A, Smith, C J, Hatleberg, C I, Brandt, R S, Grevsen, A L, Lundgren, J D, Fux, C A, Monforte, A d'Arminio, Iversen, J S, Reiss, Central P, Prins, J M, Kuijpers, T W, Scherpbier, H J, van der Meer, J T M, Godfried, M H, Nellen, F J B, Geerlings, S E, Bos, J C, Wiersinga, W J, Hovius, J W, van Hes, A M H, Nobel, H E, Pijnappel, F J J, Back, N K T, Zaaijer, H L, Cornelissen, M T E, Schinkel, C J, Thomas, X V, Ziekenhuis, Admiraal De Ruyter, de Looff, L Hage, Ziekenhuis, Catharina, Pronk, M J H, Ammerlaan, H S M, De Munnik, E S, Jansz, A R, Wegdam, M C A, Weijsenfeld, A M, van der Ende, M E, De Vries-Sluijs, T E M S, van Gorp, E C M, Schurink, C A M, Nouwen, J L, Rijnders, B J A, Bax, H I, van Beek, J E A, van Zonneveld, L M, van den Berg-Cameron, H J, Bruinsma-Broekman, F B, de Man, M de Zeeuw, Boucher, C A B, Koopmans, M P G, van Kampen, J J A, Pas, S D, MC–Sophia, Erasmus, Driessen, G J A, van Rossum, A M C, van der Knaap, L C, de Ven, C J H M Duijf-van, Ziekenhuis, Haga, Schippers, E F, van IJperen, J M, Franck, P F H, Elsenburg, L J M, Kwa, I S, Groeneveld, P H P, Bouwhuis, J W, van den Berg, J F, van Hulzen, A G W, van der Bliek, G L, Bor, P C J, Wolfhagen, M J H M, Ruijs, G J H M, Kroon, F P, de Boer, M G J, Bauer, M P, Vollaard, A M, Claas, E C J, den Hollander, J G, Smit, J V, Lowe, S H, Lashof, A M L Oude, Ackens, R P, van Loo, I H M, Havenith, T R A, Leyten, E M S, Gelinck, L B S, Wildenbeest, G S, Mutsaers, J A E M, Jansen, C L, Mulder, J W, Vrouenraets, S M E, Lauw, F N, van Broekhuizen, M C, Vlasblom, D J, Smits, P H M, Zuiderzee, M C, Bosma, A S, van Vonderen, M G A, van Houte, D P F, Kampschreur, L M, Kootstra, G J, Delsing, C E, Stuart, J W T Cohen, Diederen, B M W, van Truijen-Oud, F A, van der Reijden, W A, van den Berk, G E L, Blok, W L, Frissen, P H J, Lettinga, K D, Schouten, W E M, Brouwer, C J, Geerders, G F, Kleene, M J, van der Meché, I B, Toonen, A J M, Koopmans, P P, van der Ven, A J A M, ter Hofstede, H J M, Dofferhoff, A S M, Bosch, M E W, Grintjes-Huisman, K J T, Zomer, B J, Stelma, F F, Gisolf, E H, Hassing, R J, van Bentum, P H M, Swanink, C M A, van Lelyveld, S F L, van der Prijt, L M M, Herpers, B L, Verhagen, D W M, Ziekenhuis, St Elisabeth, van Kasteren, M E E, Brouwer, A E, de Wiel, B A F M de Kruijf-van, Santegoets, R M W J, Marcelis, J H, Buiting, A G M, Kabel, P J, Bierman, W F W, Wilting, K R, Jonge, H de Groot-de, van der Meulen, P A, de Weerd, D A, Niesters, H G M, van Leer-Buter, C C, Hoepelman, A I M, Ellerbroek, P M, Oosterheert, J J, Arends, J E, Barth, R E, Wassenberg, M W M, Schadd, E M, van Elst-Laurijssen, D H M, van Oers-Hazelzet, E E B, Wensing, A M J, Peters, E J G, van Agtmael, M A, Laan, L M, Pettersson, A M, Vandenbroucke-Grauls, C M J E, Ang, C W, Kinderziekenhuis, Wilhelmina, Geelen, S P M, Wolfs, T F W, Bont, L J, Bezemer, D O, van Sighem, A I, Boender, T S, Rademaker, M J, Pellegrin, J L, Vareil, M O, Dauchy, F A, Receveur, M C, Vandenhende, M A, Viallard, J F, Lafon, Me, Blaizeau, M J, Boerg, Eloïse, Law, Central M, Calvo, Central G, Sambeat, M A, Gennotte, A F, Payen, M C, Neaton, Central J, El-Sadr, W M, Abrams, D I, Crane, L R, Fischer, A H, Larsen, J F, Wien, Pulmologisches Zentrum der Stadt, Mitsura, V M, Møller, N F, Nielsen, L N, Smidt, Jelena, Siseklinik, Nakkusosakond, Viard, J-P, Stellbrink, H J, Goethe, J W, Sthoeger, Z M, Monforte, A D’Arminio, Annunziata, Ospedale S Maria, Blokhina, I N, Novogrod, Nizhny, Gatell, J M, Miró, J M, Rodriguez, J M, Laporte, J M, Johnson, A M, Johnson, M A, Morfeldt, Central L, Perri, G Di, Marchetti, G C, Perno, C F, Caputo, S Lo, Capobianchi, M R, Biagio, A Di, Roldan, E Quiros, Santoro, M M, Caro, A Di, Manconi, P E, Moioli, M C, Ridolfo, A L, Martino, F Di, Cattelan, A M, Ursitti, M A, Sulekova, L Fontanelli, Plazzi, M M, Del Vecchio, R Fontana, Giuli, C Di, Orofino, G C, Roger, P M, Braun, D L, Bucher, H C, Günthard, H F, Hirsch, H H, Kouyos, R D, de Tejada, B Martinez, Metzner, K J, Scherrer, A U, Valk, Marc vd, Han, W Min, Saint-Pierre, C H U, Miro, J M, Wasmuth, J C, Vehreschild, J J, McNicholl, I, Williams, E D, Volny-Anne, R Campo Alain, Dedes, Nikos, Mendão, Luis, Jakobsen, M L, Kumar, L Ramesh, Elsing, T W, and null, null
- Abstract
Background: Mortality among people with HIV declined with the introduction of combination antiretroviral therapy. We investigated trends over time in all-cause and cause-specific mortality in people with HIV from 1999-2020. Methods: Data were collected from the D:A:D cohort from 1999 through January 2015 and RESPOND from October 2017 through 2020. Age-standardized all-cause and cause-specific mortality rates, classified using Coding Causes of Death in HIV (CoDe), were calculated. Poisson regression models were used to assess mortality trends over time. Results: Among 55716 participants followed for a median of 6 years (IQR 3-11), 5263 participants died (crude mortality rate [MR] 13.7/1000 PYFU; 95%CI 13.4-14.1). Changing patterns of mortality were observed with AIDS as the most common cause of death between 1999- 2009 (n = 952, MR 4.2/1000 PYFU; 95%CI 4.0-4.5) and non-AIDS defining malignancy (NADM) from 2010 -2020 (n = 444, MR 2.8/1000 PYFU; 95%CI 2.5-3.1). In multivariable analysis, all-cause mortality declined over time (adjusted mortality rate ratio [aMRR] 0.97 per year; 95%CI 0.96, 0.98), mostly from 1999 through 2010 (aMRR 0.96 per year; 95%CI 0.95-0.97), and with no decline shown from 2011 through 2020 (aMRR 1·00 per year; 95%CI 0·96-1·05). Mortality due all known causes except NADM also declined over the entire follow-up period. Conclusion: Mortality among people with HIV in the D:A:D and/or RESPOND cohorts decreased between 1999 and 2009 and was stable over the period from 2010 through 2020. The decline in mortality rates was not fully explained by improvements in immunologic-virologic status or other risk factors.
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- 2024
9. Heavy arv exposure and exhausted/limited arv options: predictors and clinical outcomes
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Mocroft, Amanda, primary, Pelchen-Matthews, Annegret, additional, Hoy, Jennifer, additional, Llibre, Josep M., additional, Neesgaard, Bastian, additional, Jaschinski, Nadine, additional, Domingo, Pere, additional, Rasmussen, Line Dahlerup, additional, Günthard, Huldrych F., additional, Surial, Bernard, additional, Öllinger, Angela, additional, Knappik, Michael, additional, De Wit, Stephan, additional, Wit, Ferdinand, additional, Mussini, Cristina, additional, Vehreschild, Joerg, additional, Monforte, Antonella D’Arminio, additional, Sonnerborg, Anders, additional, Castagna, Antonella, additional, Anne, Alain Volny, additional, Vannappagari, Vani, additional, Cohen, Cal, additional, Greaves, Wayne, additional, Wasmuth, Jan C., additional, Spagnuolo, Vincenzo, additional, and Ryom, Lene, additional
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- 2023
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10. Prevalence and Outcomes for Heavily Treatment-Experienced Individuals Living With Human Immunodeficiency Virus in a European Cohort
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Pelchen-Matthews, Annegret, Borges, Álvaro H., Reekie, Joanne, Rasmussen, Line D., Wiese, Lothar, Weber, Jonathan, Pradier, Christian, Degen, Olaf, Paredes, Roger, Tau, Luba, Flamholc, Leo, Gottfredsson, Magnus, Kowalska, Justyna, Jablonowska, Elzbieta, Mozer-Lisewska, Iwona, Radoi, Roxana, Vasylyev, Marta, Kuznetsova, Anastasiia, Begovac, Josip, Svedhem, Veronica, Clark, Andrew, and Cozzi-Lepri, Alessandro
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- 2021
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11. Infectious HIV-1 Assembles in Late Endosomes in Primary Macrophages
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Pelchen-Matthews, Annegret, Kramer, Beatrice, and Marsh, Mark
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- 2003
12. Endocytosis and Recycling of the HIV Coreceptor CCR5
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Signoret, Nathalie, Pelchen-Matthews, Annegret, Mack, Matthias, and Marsh, Mark
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- 2000
13. Phorbol Esters and SDF-1 Induce Rapid Endocytosis and down Modulation of the Chemokine Receptor CXCR4
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Signoret, Natalie, Oldridge, Joanne, Pelchen-Matthews, Annegret, Klasse, Per J., Tran, Thanh, Brass, Lawrence F., Rosenkilde, Mette M., Schwartz, Thue W., Holmes, William, Dallas, Walt, Luther, Michael A., Hoxie, James A., and Marsh, Mark
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- 1997
14. An Internalization Signal in the Simian Immunodeficiency Virus Transmembrane Protein Cytoplasmic Domain Modulates Expression of Envelope Glycoproteins on the Cell Surface
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Sauter, Monica M., Pelchen-Matthews, Annegret, Bron, Romke, Marsh, Mark, LaBranche, Celia C., Vance, Patricia J., Romano, Josephine, Haggarty, Beth S., Hart, Timothy K., and Hoxie, James A.
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- 1996
15. Uptake and effectiveness of two-drug compared with three-drug antiretroviral regimens among HIV-positive individuals in Europe
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Neesgaard, Bastian, Pelchen-Matthews, Annegret, Ryom, Lene, Florence, Eric, Peters, Lars, Roen, Ashley, Svedhem, Veronika, Clarke, Amanda, Benfield, Thomas, Mitsura, Viktar, Moreno, Santiago, Beniowski, Marek, Begovac, Josip, Matulionyte, Raimonda, Trofimova, Tatyana, Elbirt, Daniel, Kundro, Mariana, Vullo, Vincenzo, Behrens, Georg, Staub, Therese, Ragone, Leigh, Vannappagari, Vani, Lundgren, Jens, and Mocroft, Amanda
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- 2019
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16. Recent abacavir use and incident cardiovascular disease in contemporary-treated people with HIV
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Jaschinski, Nadine, Greenberg, Lauren, Neesgaard, Bastian, Miró, Jose M., Grabmeier-Pfistershammer, Katharina, Wandeler, Gilles, Smith, Colette, De Wit, Stéphane, Wit, Ferdinand, Pelchen-Matthews, Annegret, Mussini, Cristina, Castagna, Antonella, Pradier, Christian, D'Arminio Monforte, Antonella, Vehreschild, Jörg, Sönnerborg, Anders, Anne, Alain V., Carr, Andrew, Bansi-Matharu, Loveleen, Lundgren, Jens, Garges, Harmony, Rogatto, Felipe, Zangerle, Robert, Günthard, Huldrych F., Rasmussen, Line D., Nescoi, Coca, Van Der Valk, Marc, Menozzi, Marianna, Muccini, Camilla, Mocroft, Amanda, Peters, Lars, Ryom, Lene, Jaschinski, Nadine, Greenberg, Lauren, Neesgaard, Bastian, Miró, Jose M., Grabmeier-Pfistershammer, Katharina, Wandeler, Gilles, Smith, Colette, De Wit, Stéphane, Wit, Ferdinand, Pelchen-Matthews, Annegret, Mussini, Cristina, Castagna, Antonella, Pradier, Christian, D'Arminio Monforte, Antonella, Vehreschild, Jörg, Sönnerborg, Anders, Anne, Alain V., Carr, Andrew, Bansi-Matharu, Loveleen, Lundgren, Jens, Garges, Harmony, Rogatto, Felipe, Zangerle, Robert, Günthard, Huldrych F., Rasmussen, Line D., Nescoi, Coca, Van Der Valk, Marc, Menozzi, Marianna, Muccini, Camilla, Mocroft, Amanda, Peters, Lars, and Ryom, Lene
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Objective:Assessing whether the previously reported association between abacavir (ABC) and cardiovascular disease (CVD) remained amongst contemporarily treated people with HIV.Design:Multinational cohort collaboration.Methods:RESPOND participants were followed from the latest of 1 January 2012 or cohort enrolment until the first of a CVD event (myocardial infarction, stroke, invasive cardiovascular procedure), last follow-up or 31 December 2019. Logistic regression examined the odds of starting ABC by 5-year CVD or chronic kidney disease (CKD) D:A:D risk score. We assessed associations between recent ABC use (use within the past 6 months) and risk of CVD with negative binomial regression models, adjusted for potential confounders.Results:Of 29 340 individuals, 34% recently used ABC. Compared with those at low estimated CVD and CKD risks, the odds of starting ABC were significantly higher among individuals at high CKD risk [odds ratio 1.12 (95% confidence interval = 1.04-1.21)] and significantly lower for individuals at moderate, high or very high CVD risk [0.80 (0.72-0.88), 0.75 (0.64-0.87), 0.71 (0.56-0.90), respectively]. During 6.2 years of median follow-up (interquartile range; 3.87-7.52), there were 748 CVD events (incidence rate 4.7 of 1000 persons-years of follow up (4.3-5.0)]. The adjusted CVD incidence rate ratio was higher for individuals with recent ABC use [1.40 (1.20-1.64)] compared with individuals without, consistent across sensitivity analyses. The association did not differ according to estimated CVD (interaction P = 0.56) or CKD (P = 0.98) risk strata.Conclusion:Within RESPOND's contemporarily treated population, a significant association between CVD incidence and recent ABC use was confirmed and not explained by preferential ABC use in individuals at increased CVD or CKD risk.
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- 2023
17. Corrigendum to “Long-term impact of immediate versus deferred antiretroviral therapy on kidney health in people with HIV.” Kidney International 2024;106:136–144
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Pelchen-Matthews, Annegret, Mocroft, Amanda, Ryom, Lene, Ross, Michael J., Sharma, Shweta, Coca, Steven, Achhra, Amit, Cornell, Elaine, Tracy, Russell, Phillips, Andrew, Alonso, Marta Montero, Toulomi, Giota, Agan, Brian K., Medland, Nicholas, and Wyatt, Christina M.
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- 2024
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18. Aging and the evolution of comorbidities among HIV-positive individuals in a European cohort
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Pelchen-Matthews, Annegret, Ryom, Lene, Borges, Álvaro H., Edwards, Simon, Duvivier, Claudine, Stephan, Christoph, Sambatakou, Helen, Maciejewska, Katarzyna, Portu, José Joaquín, Weber, Jonathan, Degen, Olaf, Calmy, Alexandra, Reikvam, Dag Henrik, Jevtovic, Djordje, Wiese, Lothar, Smidt, Jelena, Smiatacz, Tomasz, Hassoun, Gamal, Kuznetsova, Anastasiia, Clotet, Bonaventura, Lundgren, Jens, and Mocroft, Amanda
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- 2018
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19. Incidence and risk factors for suicide, death due to substance use, and violent/accidental death in people with HIV
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Tusch, Erich S., primary, Ryom, Lene, additional, Fursa, Olga, additional, Peters, Lars, additional, Østergaard, Lars, additional, Florence, Eric, additional, Edwards, Simon, additional, Hoffmann, Christian, additional, Sambatakou, Helen, additional, Reiss, Peter, additional, Shahar, Eduardo, additional, Reikvam, Dag Henrik, additional, Schmied, Brigitte, additional, Paduta, Dzmitry, additional, Yakovlev, Alexei, additional, Szlávik, János, additional, Ranin, Jovan, additional, Zilmer, Kai, additional, Uždaviniene, Vilma, additional, Pelchen-Matthews, Annegret, additional, Mocroft, Amanda, additional, and Reekie, Joanne, additional
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- 2022
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20. Recent abacavir use and incident cardiovascular disease in contemporary-treated people with HIV
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Jaschinski, Nadine, primary, Greenberg, Lauren, additional, Neesgaard, Bastian, additional, Miró, Jose M., additional, Grabmeier-Pfistershammer, Katharina, additional, Wandeler, Gilles, additional, Smith, Colette, additional, De Wit, Stéphane, additional, Wit, Ferdinand, additional, Pelchen-Matthews, Annegret, additional, Mussini, Cristina, additional, Castagna, Antonella, additional, Pradier, Christian, additional, d’Arminio Monforte, Antonella, additional, Vehreschild, Jörg, additional, Sönnerborg, Anders, additional, Anne, Alain V., additional, Carr, Andrew, additional, Bansi-Matharu, Loveleen, additional, Lundgren, Jens, additional, Garges, Harmony, additional, Rogatto, Felipe, additional, Zangerle, Robert, additional, Günthard, Huldrych F., additional, Rasmussen, Line D., additional, Nescoi, Coca, additional, Van Der Valk, Marc, additional, Menozzi, Marianna, additional, Muccini, Camilla, additional, Mocroft, Amanda, additional, Peters, Lars, additional, and Ryom, Lene, additional
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- 2022
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21. Simian Immunodeficiency Virus Envelope Glycoprotein Counteracts Tetherin/BST-2/CD317 by Intracellular Sequestration
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Gupta, Ravindra K., Mlcochova, Petra, Pelchen-Matthews, Annegret, Petit, Sarah J., Mattiuzzo, Giada, Pillay, Deenan, Takeuchi, Yasuhiro, Marsh, Mark, Towers, Greg J., and Coffin, John M.
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- 2009
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22. Integrase Strand Transfer Inhibitor Use and Cancer Incidence in a Large Cohort Setting
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Greenberg, Lauren, Ryom, Lene, Neesgaard, Bastian, Miro, Jose M., Rasmussen, Line Dahlerup, Zangerle, Robert, Grabmeier-Pfistershammer, Katharina, Gunthard, Huldrych F., Kusejko, Katharina, Smith, Colette, Mussini, Cristina, Menozzi, Marianna, Wit, Ferdinand, Van der Valk, Marc, Monforte, Antonella d'Arminio, De Wit, Stephane, Necsoi, Coca, Pelchen-Matthews, Annegret, Lundgren, Jens, Peters, Lars, Castagna, Antonella, Muccini, Camilla, Vehreschild, Joerg Janne, Pradier, Christian, Riera, Andreu Bruguera, Sonnerborg, Anders, Petoumenos, Kathy, Garges, Harmony, Rogatto, Felipe, Dedes, Nikos, Bansi-Matharu, Loveleen, Mocroft, Amanda, Greenberg, Lauren, Ryom, Lene, Neesgaard, Bastian, Miro, Jose M., Rasmussen, Line Dahlerup, Zangerle, Robert, Grabmeier-Pfistershammer, Katharina, Gunthard, Huldrych F., Kusejko, Katharina, Smith, Colette, Mussini, Cristina, Menozzi, Marianna, Wit, Ferdinand, Van der Valk, Marc, Monforte, Antonella d'Arminio, De Wit, Stephane, Necsoi, Coca, Pelchen-Matthews, Annegret, Lundgren, Jens, Peters, Lars, Castagna, Antonella, Muccini, Camilla, Vehreschild, Joerg Janne, Pradier, Christian, Riera, Andreu Bruguera, Sonnerborg, Anders, Petoumenos, Kathy, Garges, Harmony, Rogatto, Felipe, Dedes, Nikos, Bansi-Matharu, Loveleen, and Mocroft, Amanda
- Abstract
In this analysis including 29 340 individuals from RESPOND and 1078 cancer events, the incidence of cancer decreased as cumulative INSTI exposure increased in ART-naive individuals, however there was no association between cancer risk and INSTI exposure in ART-experienced individuals. Background Limited data exist examining the association between incident cancer and cumulative integrase inhibitor (INSTI) exposure. Methods Participants were followed from baseline (latest of local cohort enrollment or January 1, 2012) until the earliest of first cancer, final follow-up, or December 31, 2019. Negative binomial regression was used to assess associations between cancer incidence and time-updated cumulative INSTI exposure, lagged by 6 months. Results Of 29 340 individuals, 74% were male, 24% were antiretroviral treatment (ART)-naive, and median baseline age was 44 years (interquartile range [IQR], 36-51). Overall, 13 950 (48%) individuals started an INSTI during follow-up. During 160 657 person-years of follow-up ([PYFU] median 6.2; IQR, 3.9-7.5), there were 1078 cancers (incidence rate [IR] 6.7/1000 PYFU; 95% confidence interval [CI], 6.3-7.1). The commonest cancers were non-Hodgkin lymphoma (n = 113), lung cancer (112), Kaposi's sarcoma (106), and anal cancer (103). After adjusting for potential confounders, there was no association between cancer risk and INSTI exposure (<= 6 months vs no exposure IR ratio: 1.15 [95% CI, 0.89-1.49], >6-12 months; 0.97 [95% CI, 0.71-1.32], >12-24 months; 0.84 [95% CI, 0.64-1.11], >24-36 months; 1.10 [95% CI, 0.82-1.47], >36 months; 0.90 [95% CI, 0.65-1.26] [P = .60]). In ART-naive participants, cancer incidence decreased with increasing INSTI exposure, mainly driven by a decreasing incidence of acquired immune deficiency syndrome cancers; however, there was no association between INSTI exposure and cancer for those ART-experienced (interaction P < .0001). Conclusions Cancer incidence in each INSTI exposure group was similar, despite re
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- 2022
23. Associations between integrase strand-transfer inhibitors and cardiovascular disease in people living with HIV:a multicentre prospective study from the RESPOND cohort consortium
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Neesgaard, Bastian, Greenberg, Lauren, Miró, Jose M., Grabmeier-Pfistershammer, Katharina, Wandeler, Gilles, Smith, Colette, De Wit, Stéphane, Wit, Ferdinand, Pelchen-Matthews, Annegret, Mussini, Cristina, Castagna, Antonella, Pradier, Christian, d'Arminio Monforte, Antonella, Vehreschild, Jörg J., Sönnerborg, Anders, Anne, Alain V., Carr, Andrew, Bansi-Matharu, Loveleen, Lundgren, Jens D., Garges, Harmony, Rogatto, Felipe, Zangerle, Robert, Günthard, Huldrych F., Rasmussen, Line D., Necsoi, Coca, van der Valk, Marc, Menozzi, Marianna, Muccini, Camilla, Peters, Lars, Mocroft, Amanda, Ryom, Lene, Neesgaard, Bastian, Greenberg, Lauren, Miró, Jose M., Grabmeier-Pfistershammer, Katharina, Wandeler, Gilles, Smith, Colette, De Wit, Stéphane, Wit, Ferdinand, Pelchen-Matthews, Annegret, Mussini, Cristina, Castagna, Antonella, Pradier, Christian, d'Arminio Monforte, Antonella, Vehreschild, Jörg J., Sönnerborg, Anders, Anne, Alain V., Carr, Andrew, Bansi-Matharu, Loveleen, Lundgren, Jens D., Garges, Harmony, Rogatto, Felipe, Zangerle, Robert, Günthard, Huldrych F., Rasmussen, Line D., Necsoi, Coca, van der Valk, Marc, Menozzi, Marianna, Muccini, Camilla, Peters, Lars, Mocroft, Amanda, and Ryom, Lene
- Abstract
Background: Although associations between older antiretroviral drug classes and cardiovascular disease in people living with HIV are well described, there is a paucity of data regarding a possible association with integrase strand-transfer inhibitors (INSTIs). We investigated whether exposure to INSTIs was associated with an increased incidence of cardiovascular disease. Methods: RESPOND is a prospective, multicentre, collaboration study between 17 pre-existing European and Australian cohorts and includes more than 32 000 adults living with HIV in clinical care after Jan 1, 2012. Individuals were eligible for inclusion in these analyses if they were older than 18 years, had CD4 cell counts and HIV viral load measurements in the 12 months before or within 3 months after baseline (latest of cohort enrolment or Jan 1, 2012), and had no exposure to INSTIs before baseline. These individuals were subsequently followed up to the earliest of the first cardiovascular disease event (ie, myocardial infarction, stroke, or invasive cardiovascular procedure), last follow-up, or Dec 31, 2019. We used multivariable negative binomial regression to assess associations between cardiovascular disease and INSTI exposure (0 months [no exposure] vs >0 to 6 months, >6 to 12 months, >12 to 24 months, >24 to 36 months, and >36 months), adjusted for cardiovascular risk factors. RESPOND is registered with ClinicalTrials.gov, NCT04090151, and is ongoing. Findings: 29 340 people living with HIV were included in these analyses, of whom 7478 (25·5%) were female, 21 818 (74·4%) were male, and 44 (<1%) were transgender, with a median age of 44·3 years (IQR 36·2–51·3) at baseline. As of Dec 31, 2019, 14 000 (47·7%) of 29 340 participants had been exposed to an INSTI. During a median follow-up of 6·16 years (IQR 3·87–7·52; 160 252 person-years), 748 (2·5%) individuals had a cardiovascular disease event (incidence rate of 4·67 events [95% CI 4·34–5·01] per 1000 person-years of foll
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- 2022
24. In Macrophages, HIV-1 Assembles into an Intracellular Plasma Membrane Domain Containing the Tetraspanins CD81, CD9, and CD53
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Deneka, Magdalena, Pelchen-Matthews, Annegret, Byland, Rahel, Ruiz-Mateos, Ezequiel, and Marsh, Mark
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- 2007
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25. Endocytosis of CD4 in Lymphoid and Non-Lymphoid Cells
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Pelchen-Matthews, Annegret, Armes, Jane E., Marsh, Mark, and Courtoy, Pierre J., editor
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- 1992
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26. On the Role of Endocytosis in the Entry of Animal Viruses
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Marsh, Mark, Pelchen-Matthews, Annegret, and Courtoy, Pierre J., editor
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- 1992
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27. Incidence and risk factors for suicide, death due to substance use, and violent/accidental death in people with HIV.
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Tusch, Erich S., Ryom, Lene, Fursa, Olga, Peters, Lars, Østergaard, Lars, Florence, Eric, Edwards, Simon, Hoffmann, Christian, Sambatakou, Helen, Reiss, Peter, Shahar, Eduardo, Reikvam, Dag Henrik, Schmied, Brigitte, Paduta, Dzmitry, Yakovlev, Alexei, Szlávik, János, Ranin, Jovan, Zilmer, Kai, Uždaviniene, Vilma, and Pelchen-Matthews, Annegret
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- 2023
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28. The Protein Tyrosine Kinase p56lck Inhibits CD4 Endocytosis by Preventing Entry of CD4 into Coated Pits
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Pelchen-Matthews, Annegret, Boulet, Isabelle, Littman, Dan R., Fagard, Remi, and Marsh, Mark
- Published
- 1992
29. Central Action of Dendrotoxin: Selective Reduction of a Transient K Conductance in Hippocampus and Binding to Localized Acceptors
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Halliwell, James V., Othman, Iekhsan B., Pelchen-Matthews, Annegret, and Dolly, J. Oliver
- Published
- 1986
30. Clinical outcomes of two-drug regimens vs. three-drug regimens in antiretroviral treatment-experienced people living with HIV
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Greenberg, Lauren, Ryom, Lene, Neesgaard, Bastian, Wandeler, Gilles, Staub, Therese, Gisinger, Martin, Skoll, Michael, Günthard, Huldrych F, Scherrer, Alexandra, Mussini, Cristina, Smith, Colette, Johnson, Margaret, De Wit, Stéphane, Necsoi, Coca, Pradier, Christian, Wit, Ferdinand, Lehmann, Clara, d’Arminio Monforte, Antonella, Miró, Jose M, Castagna, Antonella, Spagnuolo, Vincenzo, Sönnerborg, Anders, Law, Matthew, Hutchinson, Jolie, Chkhartishvili, Nikoloz, Bolokadze, Natalia, Wasmuth, Jan-Christian, Stephan, Christoph, Vannappagari, Vani, Rogatto, Felipe, Llibre, Josep M, Duvivier, Claudine, Hoy, Jennifer, Bloch, Mark, Bucher, Heiner C, Calmy, Alexandra, Volny Anne, Alain, Pelchen-Matthews, Annegret, Lundgren, Jens D, Peters, Lars, Bansi-Matharu, Loveleen, Mocroft, Amanda, Greenberg, Lauren, Ryom, Lene, Neesgaard, Bastian, Wandeler, Gille, Staub, Therese, Gisinger, Martin, Skoll, Michael, Günthard, Huldrych F, Scherrer, Alexandra, Mussini, Cristina, Smith, Colette, Johnson, Margaret, De Wit, Stéphane, Necsoi, Coca, Pradier, Christian, Wit, Ferdinand, Lehmann, Clara, d'Arminio Monforte, Antonella, Miró, Jose M, Castagna, Antonella, Spagnuolo, Vincenzo, Sönnerborg, Ander, Law, Matthew, Hutchinson, Jolie, Chkhartishvili, Nikoloz, Bolokadze, Natalia, Wasmuth, Jan-Christian, Stephan, Christoph, Vannappagari, Vani, Rogatto, Felipe, Llibre, Josep M, Duvivier, Claudine, Hoy, Jennifer, Bloch, Mark, Bucher, Heiner C, Calmy, Alexandra, Volny Anne, Alain, Pelchen-Matthews, Annegret, Lundgren, Jens D, Peters, Lar, Bansi-Matharu, Loveleen, and Mocroft, Amanda
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antiretroviral treatment ,two-drug regimens ,HIV ,610 Medicine & health ,dual therapy ,clinical outcomes - Abstract
Background: Limited data exist comparing clinical outcomes of two-drug regimens (2DRs) and three-drug regimens (3DRs) in people living with HIV. Methods: Antiretroviral treatment-experienced individuals in RESPOND switching to a new 2DR or 3DR from 1/1/12-1/10/18 were included. The incidence of clinical events (AIDS, non-AIDS cancer, cardiovascular disease, end-stage liver and renal disease, death) was compared between regimens using Poisson regression. Results: Of 9791 individuals included, 1088 (11.1%) started 2DRs and 8703 (88.9%) 3DRs. The most common 2DRs were dolutegravir plus lamivudine (22.8%) and raltegravir plus boosted darunavir (19.8%); the most common 3DR was dolutegravir plus 2 nucleoside reverse transcriptase inhibitors (46.9%). Individuals on 2DRs were older (median 52.6 years [interquartile range 46.7-59.0] vs 47.7 [39.7-54.3]), and a higher proportion had ≥1 comorbidity (81.6% vs 73.9%).There were 619 events during 27,159 person-years of follow-up (PYFU): 540 (incidence rate [IR] 22.5/1000 PYFU [95% CI 20.7-24.5]) on 3DRs, 79 (30.9/1000 PYFU [24.8-38.5]) on 2DRs. The most common events were death (7.5/1000 PYFU [95% CI 6.5-8.6]) and non-AIDS cancer (5.8/1000 PYFU [4.9-6.8]). After adjustment for baseline demographic and clinical characteristics, there was a similar incidence of events on both regimen types (2DRs vs 3DRs IR ratio: 0.92 [0.72-1.19]; p=0.53). Conclusions: This is the first large, international cohort assessing clinical outcomes on 2DRs. After accounting for baseline characteristics, there was a similar incidence of events on 2DRs and 3DRs. 2DRs appear to be a viable treatment option with regard to clinical outcomes; further research on resistance barriers and long-term durability of 2DRs is needed.
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- 2020
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31. Hypersensitivity reactions, hepatotoxicity, and other discontinuations in persons receiving integrase strand transfer inhibitors:results from the EuroSIDA study
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Pelchen-Matthews, Annegret, Larsen, Jakob Friis, Shepherd, Leah, Begovac, Josip, Pedersen, Karen, De Wit, Stéphane, Horban, Andrzej, Jablonowska, Elzbieta, Johnson, Margaret, Khromova, Irina, Losso, Marcelo H., Nielsen, Lars N., Ridolfo, Anna Lisa, Schmied, Brigitte, Stephan, Christoph, Yust, Israel, Curtis, Lloyd, Vannappagari, Vani, Ragone, Leigh, Roen, Ashley, Raben, Dorthe, Kirk, Ole, Peters, Lars, and Mocroft, Amanda
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integrase strand transfer inhibitors ,hepatotoxicity ,Human immunodeficiency virus ,serious adverse events ,antiretroviral therapy ,hypersensitivity reaction ,dolutegravir - Abstract
Background: Hypersensitivity reaction (HSR) and hepatotoxicity are rare, but potentially serious side-effects of antiretroviral use. Objective: To investigate discontinuations due to HSR, hepatotoxicity or other reasons among users of dolutegravir (DTG) vs. raltegravir (RAL) or elvitegravir (EVG) in the EuroSIDA cohort. Methods: We compared individuals ≥18 years and starting combination antiretroviral therapy (ART, ≥3 drugs) with DTG vs. RAL or EVG, with or without abacavir (ABC), between January 16, 2014 and January 23, 2019. Discontinuations due to serious adverse events (SAEs) were independently reviewed. Results: Altogether 4366 individuals started 5116 ART regimens including DTG, RAL, or EVG, contributing 9180 person-years of follow-up (PYFU), with median follow-up 1.6 (interquartile range 0.7–2.8) years per treatment episode. Of these, 3074 (60.1%) used DTG (1738 with ABC, 1336 without) and 2042 (39.9%) RAL or EVG (286 with ABC, 1756 without). 1261 (24.6%) INSTI episodes were discontinued, 649 of the DTG-containing regimens (discontinuation rate 115, 95% CI 106–124/1000 PYFU) and 612 RAL or EVG-containing regimens (173, CI 160–188/1000 PYFU). After independent review, there were five HSR discontinuations, two for DTG (one with and one without ABC, discontinuation rate 0.35, CI 0.04–1.28/1000 PYFU), and three for RAL or EVG without ABC (0.85, CI 0.18–2.48/1000 PYFU). There was one hepatotoxicity discontinuation on DTG with ABC (discontinuation rate 0.18, CI 0.00–0.99/1000 PYFU). Conclusion: During 5 years of observations in the EuroSIDA cohort independently reviewed discontinuations due to HSR or hepatotoxicity were very rare, indicating a low rate of SAEs.
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- 2021
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32. Clinical Outcomes of 2-Drug Regimens vs 3-Drug Regimens in Antiretroviral Treatment-Experienced People Living With Human Immunodeficiency Virus
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Greenberg, Lauren, Ryom, Lene, Neesgaard, Bastian, Wandeler, Gilles, Staub, Therese, Gisinger, Martin, Skoll, Michael, Günthard, Huldrych F., Scherrer, Alexandra, Mussini, Cristina, Smith, Colette, Johnson, Margaret, De Wit, Stéphane, Necsoi, Coca, Pradier, Christian, Wit, Ferdinand, Lehmann, Clara, d'Arminio Monforte, Antonella, Miró, Jose M., Castagna, Antonella, Spagnuolo, Vincenzo, Sönnerborg, Anders, Law, Matthew, Hutchinson, Jolie, Chkhartishvili, Nikoloz, Bolokadze, Natalia, Wasmuth, Jan Christian, Stephan, Christoph, Vannappagari, Vani, Rogatto, Felipe, Llibre, Josep M., Duvivier, Claudine, Hoy, Jennifer, Bloch, Mark, Bucher, Heiner C., Calmy, Alexandra, Volny Anne, Alain, Pelchen-Matthews, Annegret, Lundgren, Jens D., Peters, Lars, Bansi-Matharu, Loveleen, Mocroft, Amanda, Greenberg, Lauren, Ryom, Lene, Neesgaard, Bastian, Wandeler, Gilles, Staub, Therese, Gisinger, Martin, Skoll, Michael, Günthard, Huldrych F., Scherrer, Alexandra, Mussini, Cristina, Smith, Colette, Johnson, Margaret, De Wit, Stéphane, Necsoi, Coca, Pradier, Christian, Wit, Ferdinand, Lehmann, Clara, d'Arminio Monforte, Antonella, Miró, Jose M., Castagna, Antonella, Spagnuolo, Vincenzo, Sönnerborg, Anders, Law, Matthew, Hutchinson, Jolie, Chkhartishvili, Nikoloz, Bolokadze, Natalia, Wasmuth, Jan Christian, Stephan, Christoph, Vannappagari, Vani, Rogatto, Felipe, Llibre, Josep M., Duvivier, Claudine, Hoy, Jennifer, Bloch, Mark, Bucher, Heiner C., Calmy, Alexandra, Volny Anne, Alain, Pelchen-Matthews, Annegret, Lundgren, Jens D., Peters, Lars, Bansi-Matharu, Loveleen, and Mocroft, Amanda
- Abstract
BACKGROUND: Limited data exist that compare clinical outcomes of 2-drug regimens (2DRs) and 3-drug regimens (3DRs) in people living with human immunodeficiency virus. METHODS: Antiretroviral treatment-experienced individuals in the International Cohort Consortium of Infectious Diseases (RESPOND) who switched to a new 2DR or 3DR from 1 January 2012-1 October 2018 were included. The incidence of clinical events (AIDS, non-AIDS cancer, cardiovascular disease, end-stage liver and renal disease, death) was compared between regimens using Poisson regression. RESULTS: Of 9791 individuals included, 1088 (11.1%) started 2DRs and 8703 (88.9%) started 3DRs. The most common 2DRs were dolutegravir plus lamivudine (22.8%) and raltegravir plus boosted darunavir (19.8%); the most common 3DR was dolutegravir plus 2 nucleoside reverse transcriptase inhibitors (46.9%). Individuals on 2DRs were older (median, 52.6 years [interquartile range, 46.7-59.0] vs 47.7 [39.7-54.3]), and a higher proportion had ≥1 comorbidity (81.6% vs 73.9%). There were 619 events during 27 159 person-years of follow-up (PYFU): 540 (incidence rate [IR] 22.5/1000 PYFU; 95% confidence interval [CI]: 20.7-24.5) on 3DRs and 79 (30.9/1000 PYFU; 95% CI: 24.8-38.5) on 2DRs. The most common events were death (7.5/1000 PYFU; 95% CI: 6.5-8.6) and non-AIDS cancer (5.8/1000 PYFU; 95% CI: 4.9-6.8). After adjustment for baseline demographic and clinical characteristics, there was a similar incidence of events on both regimen types (2DRs vs 3DRs IR ratio, 0.92; 95% CI: .72-1.19; P = .53). CONCLUSIONS: This is the first large, international cohort to assess clinical outcomes on 2DRs. After accounting for baseline characteristics, there was a similar incidence of events on 2DRs and 3DRs. 2DRs appear to be a viable treatment option with regard to clinical outcomes. Further research on resistance barriers and long-term durability of 2DRs is needed.
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- 2021
33. Electron Microscopy Analysis of Viral Morphogenesis
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Pelchen‐Matthews, Annegret and Marsh, Mark
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- 2007
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34. Prevalence and outcomes of pregnancies in women with HIV over a 20-year period
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Kowalska, Justyna D., primary, Pelchen-Matthews, Annegret, additional, Ryom, Lene, additional, Losso, Marcelo H., additional, Trofimova, Tatiana, additional, Mitsura, Viktar M., additional, Khromova, Irina, additional, Paduta, Dzmitry, additional, Stephan, Christoph, additional, Domingo, Pere, additional, Bakowska, Elzbieta, additional, Monforte, Antonella d’Arminio, additional, Oestergaard, Lars, additional, Jablonowska, Elzbieta, additional, Kuznetsova, Anastasiia, additional, Moreno, Santiago, additional, Vasylyev, Marta, additional, Pradier, Christian, additional, Battegay, Manuel, additional, Vandekerckhove, Linos, additional, Castagna, Antonella, additional, Raben, Dorthe, additional, and Mocroft, Amanda, additional
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- 2021
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35. β2 Integrin Adhesion Complexes Maintain the Integrity of HIV-1 Assembly Compartments in Primary Macrophages
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Pelchen-Matthews, Annegret, Giese, Sebastian, Mlčochová, Petra, Turner, Jane, and Marsh, Mark
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- 2012
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36. HIV interaction with endosomes in macrophages and dendritic cells
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Kramer, Beatrice, Pelchen-Matthews, Annegret, Deneka, Magdalena, Garcia, Eduardo, Piguet, Vincent, and Marsh, Mark
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- 2005
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37. Virologic and immunologic outcomes of treatment with integrase inhibitors in a real-world setting:The RESPOND cohort consortium
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Neesgaard, Bastian, Mocroft, Amanda, Zangerle, Robert, Wit, Ferdinand, Lampe, Fiona, Günthard, Huldrych F, Necsoi, Coca, Law, Matthew, Mussini, Cristina, Castagna, Antonella, Monforte, Antonella d'Arminio, Pradier, Christian, Chkhartisvilli, Nikoloz, Reyes-Uruena, Juliana, Vehreschild, Jörg Janne, Wasmuth, Jan-Christian, Sönnerborg, Anders, Stephan, Christoph, Greenberg, Lauren, Llibre, Josep M, Volny-Anne, Alain, Peters, Lars, Pelchen-Matthews, Annegret, Vannappagari, Vani, Gallant, Joel, Rieger, Armin, Youle, Mike, Braun, Dominique, De Wit, Stephane, Petoumenos, Kathy, Borghi, Vanni, Spagnuolo, Vincenzo, Tsertsvadze, Tengiz, Lundgren, Jens, Ryom, Lene, Neesgaard, Bastian, Mocroft, Amanda, Zangerle, Robert, Wit, Ferdinand, Lampe, Fiona, Günthard, Huldrych F, Necsoi, Coca, Law, Matthew, Mussini, Cristina, Castagna, Antonella, Monforte, Antonella d'Arminio, Pradier, Christian, Chkhartisvilli, Nikoloz, Reyes-Uruena, Juliana, Vehreschild, Jörg Janne, Wasmuth, Jan-Christian, Sönnerborg, Anders, Stephan, Christoph, Greenberg, Lauren, Llibre, Josep M, Volny-Anne, Alain, Peters, Lars, Pelchen-Matthews, Annegret, Vannappagari, Vani, Gallant, Joel, Rieger, Armin, Youle, Mike, Braun, Dominique, De Wit, Stephane, Petoumenos, Kathy, Borghi, Vanni, Spagnuolo, Vincenzo, Tsertsvadze, Tengiz, Lundgren, Jens, and Ryom, Lene
- Abstract
OBJECTIVES: To compare virologic and immunologic outcomes of integrase inhibitor (INSTI)-containing, contemporary boosted protease inhibitor (PI/b)-containing and non-nucleotide reverse transcriptase inhibitor (NNRTI)-containing regimens in a real-life setting.METHODS: Using logistic regression, virologic and immunologic outcomes of INSTI use were compared to outcomes of PI/b or NNRTI treatment 12 months after treatment start or switch, for participants in the RESPOND cohort consortium. A composite treatment outcome (cTO) was used, defining success as viral load (VL) <200 copies/mL and failure as at least one of: VL ≥200 copies/mL, unknown VL in the time window, any changes of antiretroviral therapy (ART) regimen, AIDS, or death. In addition, on-treatment analysis including only individuals with known VL and no regimen changes was performed. Favorable immunologic response was defined as a 25% increase in CD4 count or as reaching ≥750 CD4 cells/μL.RESULTS: Between January 2012 and January 2019, 13,703 (33.0% ART-naïve) individuals were included, of whom 7,147 started/switched to a regimen with an INSTI, 3,102 to a PI/b and 3,454 to an NNRTI-containing regimen. The main reason for cTO failure in all treatment groups were changes in ART regimen. Compared to INSTIs, the adjusted odds ratio (aOR) of cTO success was significantly lower for PI/b (0.74 [95% confidence interval, CI 0.67-0.82], p <0.001), but similar for NNRTIs (1.07 [CI 0.97-1.17], p = 0.11). On-treatment analysis and sensitivity analyses using a VL cut-off of 50 copies/mL were consistent. Compared to INSTIs, the aORs of a 25% increase in CD4 count were lower for NNRTIs (0.80 [CI 0.71-0.91], p<0.001) and PI/b (0.87 [CI 0.76-0.99], p = 0.04).CONCLUSION: In this large analysis of a real-world population, cTO and on-treatment success were similar between INSTIs and NNRTIs, but lower for PI/b, though residual confounding cannot be fully excluded. Obtaining favorable immunologic o
- Published
- 2020
38. Virologic and immunologic outcomes of treatment with integrase inhibitors in a real-world setting: The RESPOND cohort consortium
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Neesgaard, Bastian, Mocroft, Amanda, Zangerle, Robert, Wit, Ferdinand, Lampe, Fiona C., Günthard, Hüldrych Fritz, Necsoi, Coca Valentina, Law, Mathew M.G., Mussini, Cristina, Castagna, Antonella, d'Arminio Monforte, Antonella, Pradier, Christian, Chkhartisvilli, Nikoloz, Reyes-Uruena, Juliana, Vehreschild, Jörg Janne, Wasmuth, Jan-Christian, Sönnerborg, Anders, Stephan, Christoph, Greenberg, Lauren, Llibre, Josep María, Volny-Anne, Alain, Peters, Lars, Pelchen-Matthews, Annegret, Vannappagari, Vani, Gallant, Joel J.E., Rieger, Armin, Youle, Michael, Braun, Dominique Laurent D., De Wit, Stéphane, Petoumenos, Kathy, Borghi, Vanni, Spagnuolo, Vincenzo, Tsertsvadze, Tengiz, Lundgren, Jens D, Neesgaard, Bastian, Mocroft, Amanda, Zangerle, Robert, Wit, Ferdinand, Lampe, Fiona C., Günthard, Hüldrych Fritz, Necsoi, Coca Valentina, Law, Mathew M.G., Mussini, Cristina, Castagna, Antonella, d'Arminio Monforte, Antonella, Pradier, Christian, Chkhartisvilli, Nikoloz, Reyes-Uruena, Juliana, Vehreschild, Jörg Janne, Wasmuth, Jan-Christian, Sönnerborg, Anders, Stephan, Christoph, Greenberg, Lauren, Llibre, Josep María, Volny-Anne, Alain, Peters, Lars, Pelchen-Matthews, Annegret, Vannappagari, Vani, Gallant, Joel J.E., Rieger, Armin, Youle, Michael, Braun, Dominique Laurent D., De Wit, Stéphane, Petoumenos, Kathy, Borghi, Vanni, Spagnuolo, Vincenzo, Tsertsvadze, Tengiz, and Lundgren, Jens D
- Abstract
Objectives To compare virologic and immunologic outcomes of integrase inhibitor (INSTI)-containing, contemporary boosted protease inhibitor (PI/b)-containing and non-nucleotide reverse transcriptase inhibitor (NNRTI)-containing regimens in a real-life setting. Methods Using logistic regression, virologic and immunologic outcomes of INSTI use were compared to outcomes of PI/b or NNRTI treatment 12 months after treatment start or switch, for participants in the RESPOND cohort consortium. A composite treatment outcome (cTO) was used, defining success as viral load (VL) <200 copies/mL and failure as at least one of: VL ≥200 copies/mL, unknown VL in the time window, any changes of antiretroviral therapy (ART) regimen, AIDS, or death. In addition, on-treatment analysis including only individuals with known VL and no regimen changes was performed. Favorable immunologic response was defined as a 25% increase in CD4 count or as reaching ≥750 CD4 cells/μL. Results Between January 2012 and January 2019, 13,703 (33.0% ART-naïve) individuals were included, of whom 7,147 started/switched to a regimen with an INSTI, 3,102 to a PI/b and 3,454 to an NNRTI-containing regimen. The main reason for cTO failure in all treatment groups were changes in ART regimen. Compared to INSTIs, the adjusted odds ratio (aOR) of cTO success was significantly lower for PI/b (0.74 [95% confidence interval, CI 0.67–0.82], p <0.001), but similar for NNRTIs (1.07 [CI 0.97–1.17], p = 0.11). On-treatment analysis and sensitivity analyses using a VL cut-off of 50 copies/mL were consistent. Compared to INSTIs, the aORs of a 25% increase in CD4 count were lower for NNRTIs (0.80 [CI 0.71–0.91], p<0.001) and PI/b (0.87 [CI 0.76–0.99], p = 0.04). Conclusion In this large analysis of a real-world population, cTO and on-treatment success were similar between INSTIs and NNRTIs, but lower for PI/b, though residual confounding cannot be fully excluded. Obtaining favorable immunologic outcomes were more likely for INSTI, SCOPUS: ar.j, info:eu-repo/semantics/published
- Published
- 2020
39. HIV-1 Trafficking to the Dendritic Cell–T-Cell Infectious Synapse Uses a Pathway of Tetraspanin Sorting to the Immunological Synapse
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Garcia, Eduardo, Pion, Marjorie, Pelchen-Matthews, Annegret, Collinson, Lucy, Arrighi, Jean-Francois, Blot, Guillaume, Leuba, Florence, Escola, Jean-Michel, Demaurex, Nicolas, Marsh, Mark, and Piguet, Vincent
- Published
- 2005
40. Endosomes, exosomes and Trojan viruses
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Pelchen-Matthews, Annegret, Raposo, Graça, and Marsh, Mark
- Published
- 2004
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41. Hypersensitivity reactions, hepatotoxicity, and other discontinuations in persons receiving integrase strand transfer inhibitors: results from the EuroSIDA study.
- Author
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Pelchen-Matthews, Annegret, Larsen, Jakob Friis, Shepherd, Leah, Begovac, Josip, Pedersen, Karen, De Wit, Stéphane, Horban, Andrzej, Jablonowska, Elzbieta, Johnson, Margaret, Khromova, Irina, Losso, Marcelo H., Nielsen, Lars N., Ridolfo, Anna Lisa, Schmied, Brigitte, Stephan, Christoph, Yust, Israel, Curtis, Lloyd, Vannappagari, Vani, Ragone, Leigh, and Roen, Ashley
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HEPATOTOXICOLOGY ,ALLERGIES ,ANTIRETROVIRAL agents ,DOLUTEGRAVIR ,HIV - Abstract
Background: Hypersensitivity reaction (HSR) and hepatotoxicity are rare, but potentially serious side-effects of antiretroviral use. Objective: To investigate discontinuations due to HSR, hepatotoxicity or other reasons among users of dolutegravir (DTG) vs. raltegravir (RAL) or elvitegravir (EVG) in the EuroSIDA cohort. Methods: We compared individuals ≥18 years and starting combination antiretroviral therapy (ART, ≥3 drugs) with DTG vs. RAL or EVG, with or without abacavir (ABC), between January 16, 2014 and January 23, 2019. Discontinuations due to serious adverse events (SAEs) were independently reviewed. Results: Altogether 4366 individuals started 5116 ART regimens including DTG, RAL, or EVG, contributing 9180 person-years of follow-up (PYFU), with median follow-up 1.6 (interquartile range 0.7–2.8) years per treatment episode. Of these, 3074 (60.1%) used DTG (1738 with ABC, 1336 without) and 2042 (39.9%) RAL or EVG (286 with ABC, 1756 without). 1261 (24.6%) INSTI episodes were discontinued, 649 of the DTG-containing regimens (discontinuation rate 115, 95% CI 106–124/1000 PYFU) and 612 RAL or EVG-containing regimens (173, CI 160–188/1000 PYFU). After independent review, there were five HSR discontinuations, two for DTG (one with and one without ABC, discontinuation rate 0.35, CI 0.04–1.28/1000 PYFU), and three for RAL or EVG without ABC (0.85, CI 0.18–2.48/1000 PYFU). There was one hepatotoxicity discontinuation on DTG with ABC (discontinuation rate 0.18, CI 0.00–0.99/1000 PYFU). Conclusion: During 5 years of observations in the EuroSIDA cohort independently reviewed discontinuations due to HSR or hepatotoxicity were very rare, indicating a low rate of SAEs. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
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42. Localization of HCMV UL33 and US27 in Endocytic Compartments and Viral Membranes
- Author
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Fraile-Ramos, Alberto, Pelchen-Matthews, Annegret, Kledal, Thomas N., Browne, Helena, Schwartz, Thue W., and Marsh, Mark
- Published
- 2002
43. The protein tyrosine kinase p56(super lck) inhibits CD4 endocytosis by preventing entry of CD4 into coated pits
- Author
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Pelchen-Matthews, Annegret, Boulet, Isabelle, Littman, Dan R., Fagard, Remi, and Marsh, Mark
- Subjects
Membrane proteins -- Research ,Lymphocytes -- Research ,Endocytosis -- Research ,Biological sciences - Abstract
The endocytic trafficking of CD4, a cell surface glycoprotein primarily expressed on helper Tlymphocytes, was studied to determine the mechanism by which it is constitutively internalized and recycled, but not endocytized in lymphocytes. It was discovered that an interaction between the cytoplasmic domain of CD4 andprotein tyrosine kinase p56(super lck) or PTK prevents endocytosis. It was further discovered that PTK prevents CD4 from entering coated pits by PTK, thusinhibiting endocytosis. These discoveries present a new regulatory mechanism for the internalization of a cell surface molecule.
- Published
- 1992
44. Chemokine receptor trafficking and viral replication
- Author
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Pelchen-Matthews, Annegret, Signoret, Nathalie, Klasse, Per J., Fraile-Ramos, Alberto, and Marsh, Mark
- Published
- 1999
45. The intracellular plasma membrane-connected compartment in the assembly of HIV-1 in human macrophages
- Author
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Nkwe, David O., primary, Pelchen-Matthews, Annegret, additional, Burden, Jemima J., additional, Collinson, Lucy M., additional, and Marsh, Mark, additional
- Published
- 2016
- Full Text
- View/download PDF
46. Role of the Endosomal ESCRT Machinery in HIV-1 Vpu-Induced Down-Regulation of BST2/Tetherin.: HRS and BST-2/Tetherin Down-Regulation
- Author
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Janvier, Katy, Pelchen-Matthews, Annegret, Jean-Baptiste, Renaud, Caillet, Marina, Marsh, Mark, Berlioz-Torrent, Clarisse, Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), 3 - Cell Biology Unit, MRC Laboratory for Molecular Cell Biology, University College London, London, United Kingdom, Cell Biology Unit, University College of London [London] (UCL)-MRC Laboratory for Molecular Cell Biology-University College of London [London] (UCL)-MRC Laboratory for Molecular Cell Biology, This work is funded by SIDACTION, ANRS, the ANR-07-JCJC-0102 program, and is part of the activities of the HIV-ACE research network (HEALTH-F3-2008-201095) supported by a grant of the European Commission, within the Priority 1 Health work programme of the 7th Framework Programme of the EU., Mark Marsh, ANR-07-JCJC-0102,JC - CBT,Cellular cofactors of the HIV-1 Gag and Env proteins involved in the late steps of the HIV-1 replicative cycle.(2007), European Project: 201095,EC:FP7:HEALTH,FP7-HEALTH-2007-A,HIV ACE(2008), Berlioz-Torrent, Clarisse, Jeunes chercheuses & jeunes chercheurs - Cellular cofactors of the HIV-1 Gag and Env proteins involved in the late steps of the HIV-1 replicative cycle. - - JC - CBT2007 - ANR-07-JCJC-0102 - JCJC - VALID, and Targeting assembly of infectious HIV particles - HIV ACE - - EC:FP7:HEALTH2008-03-01 - 2011-08-31 - 201095 - VALID
- Subjects
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,viruses ,[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases - Abstract
International audience; The cellular protein "Bone marrow stromal antigen 2" (BST2 also called Tetherin, CD317, HM1.24) was identified as a major mediator of the innate immune defense against the dissemination of enveloped viruses. BST2 was shown to physically trap the de novo formed viral particles at the surface of infected cells, thereby reducing viral release. Lentiviruses have evolved specific strategies to down-regulate the expression level of BST2 from the surface of the cells and as such promote viral egress. In Human Immunodeficiency Virus-1 (HIV-1), the accessory protein Vpu counters BST2 antiviral activity. However, the cellular and molecular mechanisms involved are not fully understood. Vpu-mediated antagonism of BST2 antiviral activity seems to involve complex interplay between the viral protein and host components regulating protein turnover and vesicular trafficking. This review focuses on the interplay between Vpu and the ubiquitin/endosomal pathway in countermeasures of HIV-1 to BST2 restriction.
- Published
- 2012
47. Rab7A is required for efficient production of infectious HIV-1
- Author
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Caillet, Marina, Janvier, Katy, Pelchen-Matthews, Annegret, Delcroix-Genête, Delphine, Camus, Gregory, Marsh, Mark, Berlioz-Torrent, Clarisse, Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), University College of London [London] (UCL), M.C holds a fellowship from the 'Ministe're franc¸ais de l'enseignement supe'rieur et de la Recherche' and a fellowship from SIDACTION. G.C. holds a fellowship from ANRS. AP-M and MM were supported by UK Medical Research Council funding to the MRC Cell Biology Unit. This work is funded by ANRS, the ANR-07-JCJC-0102 program and is part of the activities of the HIV-ACE research network (HEALTH-F3-2008-201095) supported by a grant of the European Commission, within the Priority 1 'Health' work programme of the 7th Framework Programme of the EU., Mark Marsh, ANR-07-JCJC-0102,JC - CBT,Cellular cofactors of the HIV-1 Gag and Env proteins involved in the late steps of the HIV-1 replicative cycle.(2007), European Project: 201095,EC:FP7:HEALTH,FP7-HEALTH-2007-A,HIV ACE(2008), Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), 3 - Cell Biology Unit, MRC Laboratory for Molecular Cell Biology, University College London, London, United Kingdom, Cell Biology Unit, and University College of London [London] (UCL)-MRC Laboratory for Molecular Cell Biology-University College of London [London] (UCL)-MRC Laboratory for Molecular Cell Biology
- Subjects
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,virus diseases - Abstract
International audience; Retroviruses take advantage of cellular trafficking machineries to assemble and release new infectious particles. Rab proteins regulate specific steps in intracellular membrane trafficking by recruiting tethering, docking and fusion factors, as well as the actin- and microtubule-based motor proteins that facilitate vesicle traffic. Using virological tests and RNA interference targeting Rab proteins, we demonstrate that the late endosome-associated Rab7A is required for HIV-1 propagation. Analysis of the late steps of the HIV infection cycle shows that Rab7A regulates Env processing, the incorporation of mature Env glycoproteins into viral particles and HIV-1 infectivity. We also show that siRNA-mediated Rab7A depletion induces a BST2/Tetherin phenotype on HIV-1 release. BST2/Tetherin is a restriction factor that impedes HIV-1 release by tethering mature virus particles to the plasma membrane. Our results suggest that Rab7A contributes to the mechanism by which Vpu counteracts the restriction factor BST2/Tetherin and rescues HIV-1 release. Altogether, our results highlight new roles for a major regulator of the late endocytic pathway, Rab7A, in the late stages of the HIV-1 replication cycle.
- Published
- 2011
- Full Text
- View/download PDF
48. 3D correlative light and electron microscopy of cultured cells using serial blockface scanning electron microscopy
- Author
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Russell, Matthew R. G., primary, Lerner, Thomas R., additional, Burden, Jemima J., additional, Nkwe, David O., additional, Pelchen-Matthews, Annegret, additional, Domart, Marie-Charlotte, additional, Durgan, Joanne, additional, Weston, Anne, additional, Jones, Martin L., additional, Peddie, Christopher J., additional, Carzaniga, Raffaella, additional, Florey, Oliver, additional, Marsh, Mark, additional, Gutierrez, Maximiliano G., additional, and Collinson, Lucy M., additional
- Published
- 2016
- Full Text
- View/download PDF
49. Tetherin Restricts Herpes Simplex Virus 1 and Is Antagonized by Glycoprotein M
- Author
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Blondeau, Caroline, primary, Pelchen-Matthews, Annegret, additional, Mlcochova, Petra, additional, Marsh, Mark, additional, Milne, Richard S. B., additional, and Towers, Greg J., additional
- Published
- 2013
- Full Text
- View/download PDF
50. Organization and regulation of intracellular plasma membrane-connected HIV-1 assembly compartments in macrophages
- Author
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Mlcochova, Petra, primary, Pelchen-Matthews, Annegret, additional, and Marsh, Mark, additional
- Published
- 2013
- Full Text
- View/download PDF
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