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2. Mitochondrial complex I deactivation is related to superoxide production in acute hypoxia

Author

European Commission, Fundación Domingo Martínez, Instituto de Investigación Sanitaria Hospital Universitario de la Princesa, Swiss National Science Foundation, Ministerio de Economía y Competitividad (España), Universidad Autónoma de Madrid, Hernansanz-Agustín, Pablo, Ramos, Elena, Navarro, Elisa, Parada, Esther, Sánchez-López, Nuria, Peláez-Aguado, Laura, Cabrera-García, Daniel J., Tello, Daniel, Buendía Abaitua, Izaskun, Marina, Anabel, Egea Maiquez, Javier, López, Manuela G., Bogdanova, Anna, Martínez-Ruiz, Antonio, European Commission, Fundación Domingo Martínez, Instituto de Investigación Sanitaria Hospital Universitario de la Princesa, Swiss National Science Foundation, Ministerio de Economía y Competitividad (España), Universidad Autónoma de Madrid, Hernansanz-Agustín, Pablo, Ramos, Elena, Navarro, Elisa, Parada, Esther, Sánchez-López, Nuria, Peláez-Aguado, Laura, Cabrera-García, Daniel J., Tello, Daniel, Buendía Abaitua, Izaskun, Marina, Anabel, Egea Maiquez, Javier, López, Manuela G., Bogdanova, Anna, and Martínez-Ruiz, Antonio

Abstract

Mitochondria use oxygen as the final acceptor of the respiratory chain, but its incomplete reduction can also produce reactive oxygen species (ROS), especially superoxide. Acute hypoxia produces a superoxide burst in different cell types, but the triggering mechanism is still unknown. Herein, we show that complex I is involved in this superoxide burst under acute hypoxia in endothelial cells. We have also studied the possible mechanisms by which complex I could be involved in this burst, discarding reverse electron transport in complex I and the implication of PTEN-induced putative kinase 1 (PINK1). We show that complex I transition from the active to ‘deactive’ form is enhanced by acute hypoxia in endothelial cells and brain tissue, and we suggest that it can trigger ROS production through its Na/H antiporter activity. These results highlight the role of complex I as a key actor in redox signalling in acute hypoxia.

Published
2017

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