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1,444 results on '"Pekkanen, Juha"'

3. Continuous Rather Than Solely Early Farm Exposure Protects From Hay Fever Development

Author

Theodorou, Johanna, Böck, Andreas, Renz, Harald, Pfefferle, Petra I., Genuneit, Jon, Kabesch, Michael, Roponen, Marjut, Laurent, Lucie, Pechlivanis, Sonali, Depner, Martin, Kirjavainen, Pirkka V., Roduit, Caroline, Täubel, Martin, Frei, Remo, Skevaki, Chrysanthi, Hose, Alexander, Barnig, Cindy, Schmausser-Hechfellner, Elisabeth, Ege, Markus J., Schaub, Bianca, Divaret-Chauveau, Amandine, Lauener, Roger, Karvonen, Anne M., Pekkanen, Juha, Riedler, Josef, Illi, Sabina, and von Mutius, Erika

Published
2023
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5. Maternal body mass index, gestational weight gain, and the risk of overweight and obesity across childhood: An individual participant data meta-analysis

Author

Voerman, Ellis, Santos, Susana, Golab, Bernadeta Patro, Amiano, Pilar, Ballester, Ferran, Barros, Henrique, Bergström, Anna, Charles, Marie-Aline, Chatzi, Leda, Chevrier, Cécile, Chrousos, George P, Corpeleijn, Eva, Costet, Nathalie, Crozier, Sarah, Devereux, Graham, Eggesbø, Merete, Ekström, Sandra, Fantini, Maria Pia, Farchi, Sara, Forastiere, Francesco, Georgiu, Vagelis, Godfrey, Keith M, Gori, Davide, Grote, Veit, Hanke, Wojciech, Hertz-Picciotto, Irva, Heude, Barbara, Hryhorczuk, Daniel, Huang, Rae-Chi, Inskip, Hazel, Iszatt, Nina, Karvonen, Anne M, Kenny, Louise C, Koletzko, Berthold, Küpers, Leanne K, Lagström, Hanna, Lehmann, Irina, Magnus, Per, Majewska, Renata, Mäkelä, Johanna, Manios, Yannis, McAuliffe, Fionnuala M, McDonald, Sheila W, Mehegan, John, Mommers, Monique, Morgen, Camilla S, Mori, Trevor A, Moschonis, George, Murray, Deirdre, Chaoimh, Carol Ní, Nohr, Ellen A, Andersen, Anne-Marie Nybo, Oken, Emily, Oostvogels, Adriëtte JJM, Pac, Agnieszka, Papadopoulou, Eleni, Pekkanen, Juha, Pizzi, Costanza, Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Rifas-Shiman, Sheryl L, Ronfani, Luca, Santos, Ana C, Standl, Marie, Stoltenberg, Camilla, Thiering, Elisabeth, Thijs, Carel, Torrent, Maties, Tough, Suzanne C, Trnovec, Tomas, Turner, Steve, van Rossem, Lenie, von Berg, Andrea, Vrijheid, Martine, Vrijkotte, Tanja GM, West, Jane, Wijga, Alet, Wright, John, Zvinchuk, Oleksandr, Sørensen, Thorkild IA, Lawlor, Debbie A, Gaillard, Romy, and Jaddoe, Vincent WV

Subjects
Biomedical and Clinical Sciences, Public Health, Health Sciences, Nutrition and Dietetics, Reproductive Medicine, Nutrition, Prevention, Pediatric, Clinical Research, Obesity, Oral and gastrointestinal, Stroke, Reproductive health and childbirth, Cardiovascular, Generic health relevance, Metabolic and endocrine, Cancer, Australia, Body Mass Index, Cohort Studies, Data Analysis, Europe, Female, Gestational Weight Gain, Humans, North America, Overweight, Pediatric Obesity, Pregnancy, Risk Factors, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundMaternal obesity and excessive gestational weight gain may have persistent effects on offspring fat development. However, it remains unclear whether these effects differ by severity of obesity, and whether these effects are restricted to the extremes of maternal body mass index (BMI) and gestational weight gain. We aimed to assess the separate and combined associations of maternal BMI and gestational weight gain with the risk of overweight/obesity throughout childhood, and their population impact.Methods and findingsWe conducted an individual participant data meta-analysis of data from 162,129 mothers and their children from 37 pregnancy and birth cohort studies from Europe, North America, and Australia. We assessed the individual and combined associations of maternal pre-pregnancy BMI and gestational weight gain, both in clinical categories and across their full ranges, with the risks of overweight/obesity in early (2.0-5.0 years), mid (5.0-10.0 years) and late childhood (10.0-18.0 years), using multilevel binary logistic regression models with a random intercept at cohort level adjusted for maternal sociodemographic and lifestyle-related characteristics. We observed that higher maternal pre-pregnancy BMI and gestational weight gain both in clinical categories and across their full ranges were associated with higher risks of childhood overweight/obesity, with the strongest effects in late childhood (odds ratios [ORs] for overweight/obesity in early, mid, and late childhood, respectively: OR 1.66 [95% CI: 1.56, 1.78], OR 1.91 [95% CI: 1.85, 1.98], and OR 2.28 [95% CI: 2.08, 2.50] for maternal overweight; OR 2.43 [95% CI: 2.24, 2.64], OR 3.12 [95% CI: 2.98, 3.27], and OR 4.47 [95% CI: 3.99, 5.23] for maternal obesity; and OR 1.39 [95% CI: 1.30, 1.49], OR 1.55 [95% CI: 1.49, 1.60], and OR 1.72 [95% CI: 1.56, 1.91] for excessive gestational weight gain). The proportions of childhood overweight/obesity prevalence attributable to maternal overweight, maternal obesity, and excessive gestational weight gain ranged from 10.2% to 21.6%. Relative to the effect of maternal BMI, excessive gestational weight gain only slightly increased the risk of childhood overweight/obesity within each clinical BMI category (p-values for interactions of maternal BMI with gestational weight gain: p = 0.038, p < 0.001, and p = 0.637 in early, mid, and late childhood, respectively). Limitations of this study include the self-report of maternal BMI and gestational weight gain for some of the cohorts, and the potential of residual confounding. Also, as this study only included participants from Europe, North America, and Australia, results need to be interpreted with caution with respect to other populations.ConclusionsIn this study, higher maternal pre-pregnancy BMI and gestational weight gain were associated with an increased risk of childhood overweight/obesity, with the strongest effects at later ages. The additional effect of gestational weight gain in women who are overweight or obese before pregnancy is small. Given the large population impact, future intervention trials aiming to reduce the prevalence of childhood overweight and obesity should focus on maternal weight status before pregnancy, in addition to weight gain during pregnancy.

Published
2019

7. Gestational weight gain charts for different body mass index groups for women in Europe, North America, and Oceania

Author

Santos, Susana, Eekhout, Iris, Voerman, Ellis, Gaillard, Romy, Barros, Henrique, Charles, Marie-Aline, Chatzi, Leda, Chevrier, Cécile, Chrousos, George P, Corpeleijn, Eva, Costet, Nathalie, Crozier, Sarah, Doyon, Myriam, Eggesbø, Merete, Fantini, Maria Pia, Farchi, Sara, Forastiere, Francesco, Gagliardi, Luigi, Georgiu, Vagelis, Godfrey, Keith M, Gori, Davide, Grote, Veit, Hanke, Wojciech, Hertz-Picciotto, Irva, Heude, Barbara, Hivert, Marie-France, Hryhorczuk, Daniel, Huang, Rae-Chi, Inskip, Hazel, Jusko, Todd A, Karvonen, Anne M, Koletzko, Berthold, Küpers, Leanne K, Lagström, Hanna, Lawlor, Debbie A, Lehmann, Irina, Lopez-Espinosa, Maria-Jose, Magnus, Per, Majewska, Renata, Mäkelä, Johanna, Manios, Yannis, McDonald, Sheila W, Mommers, Monique, Morgen, Camilla S, Moschonis, George, Murínová, Ľubica, Newnham, John, Nohr, Ellen A, Andersen, Anne-Marie Nybo, Oken, Emily, Oostvogels, Adriëtte JJM, Pac, Agnieszka, Papadopoulou, Eleni, Pekkanen, Juha, Pizzi, Costanza, Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Rifas-Shiman, Sheryl L, Roeleveld, Nel, Santa-Marina, Loreto, Santos, Ana C, Smit, Henriette A, Sørensen, Thorkild IA, Standl, Marie, Stanislawski, Maggie, Stoltenberg, Camilla, Thiering, Elisabeth, Thijs, Carel, Torrent, Maties, Tough, Suzanne C, Trnovec, Tomas, van Gelder, Marleen MHJ, van Rossem, Lenie, von Berg, Andrea, Vrijheid, Martine, Vrijkotte, Tanja GM, Zvinchuk, Oleksandr, van Buuren, Stef, and Jaddoe, Vincent WV

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Health Sciences, Conditions Affecting the Embryonic and Fetal Periods, Pediatric, Nutrition, Obesity, Clinical Research, Prevention, Perinatal Period - Conditions Originating in Perinatal Period, Metabolic and endocrine, Reproductive health and childbirth, Good Health and Well Being, Adult, Body Mass Index, Europe, Female, Gestational Weight Gain, Humans, North America, Oceania, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Risk Factors, Weight gain, Charts, References, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundGestational weight gain differs according to pre-pregnancy body mass index and is related to the risks of adverse maternal and child health outcomes. Gestational weight gain charts for women in different pre-pregnancy body mass index groups enable identification of women and offspring at risk for adverse health outcomes. We aimed to construct gestational weight gain reference charts for underweight, normal weight, overweight, and grades 1, 2 and 3 obese women and to compare these charts with those obtained in women with uncomplicated term pregnancies.MethodsWe used individual participant data from 218,216 pregnant women participating in 33 cohorts from Europe, North America, and Oceania. Of these women, 9065 (4.2%), 148,697 (68.1%), 42,678 (19.6%), 13,084 (6.0%), 3597 (1.6%), and 1095 (0.5%) were underweight, normal weight, overweight, and grades 1, 2, and 3 obese women, respectively. A total of 138, 517 women from 26 cohorts had pregnancies with no hypertensive or diabetic disorders and with term deliveries of appropriate for gestational age at birth infants. Gestational weight gain charts for underweight, normal weight, overweight, and grade 1, 2, and 3 obese women were derived by the Box-Cox t method using the generalized additive model for location, scale, and shape.ResultsWe observed that gestational weight gain strongly differed per maternal pre-pregnancy body mass index group. The median (interquartile range) gestational weight gain at 40 weeks was 14.2 kg (11.4-17.4) for underweight women, 14.5 kg (11.5-17.7) for normal weight women, 13.9 kg (10.1-17.9) for overweight women, and 11.2 kg (7.0-15.7), 8.7 kg (4.3-13.4) and 6.3 kg (1.9-11.1) for grades 1, 2, and 3 obese women, respectively. The rate of weight gain was lower in the first half than in the second half of pregnancy. No differences in the patterns of weight gain were observed between cohorts or countries. Similar weight gain patterns were observed in mothers without pregnancy complications.ConclusionsGestational weight gain patterns are strongly related to pre-pregnancy body mass index. The derived charts can be used to assess gestational weight gain in etiological research and as a monitoring tool for weight gain during pregnancy in clinical practice.

Published
2018

18. TNF-α–induced protein 3 is a key player in childhood asthma development and environment-mediated protection

Author

Ege, Markus, Depner, Martin, Illi, Sabina, Loss, Georg J., Renz, Harald, Pfefferle, Petra I., Kabesch, Michael, Genuneit, Jon, Karvonen, Anne M., Hyvärinen, Anne, Kirjavainen, Pirkka V., Remes, Sami, Braun-Fahrländer, Charlotte, Roduit, Caroline, Frei, Remo, Kaulek, Vincent, Dalphin, Marie-Laure, Divaret-Chauveau, Amandine, Doekes, Gert, Krusche, Johanna, Twardziok, Monika, Rehbach, Katharina, Böck, Andreas, Tsang, Miranda S., Schröder, Paul C., Kumbrink, Jörg, Kirchner, Thomas, Xing, Yuhan, Riedler, Josef, Dalphin, Jean-Charles, Pekkanen, Juha, Lauener, Roger, Roponen, Marjut, Li, Jing, Wong, Chun K., Wong, Gary W.K., and Schaub, Bianca

Published
2019
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28. Exposure to nonmicrobial N-glycolylneuraminic acid protects farmers' children against airway inflammation and colitis

Author

Alfvén, Tobias, Alm, Johan, Bergström, Anna, Engstrand, Lars, Rosenlund, Helen, Hakansson, Niclas, Lilja, Gunnar, Nyberg, Frederik, Swartz, Jackie, Wickman, Magnus, Wildhaber, Johannes, Möller, Alex, Brunekreef, Bert, Boeve, Mirian, Douwes, Jeroen, Huber, Machteld, Gertraud Weiss, Mirjam Matze, Schreue, Mynda, Michles, Karin B., Sennhauser, Felix, Scheynius, Annika, Hirvonen, Maija-Riitta, Remes, Sami, Roponen, Marjut, Tiittanen, Pekka, Dalphin, Marie-Laure, Gisela Buchele, Vincent Kaulek, Ege, Markus, Kabesch, Michael, Pfefferle, Petra, Loss, Georg, Hyvärinen, Anne, Frei, Remo, Ferstl, Ruth, Roduit, Caroline, Ziegler, Mario, Schiavi, Elisa, Barcik, Weronika, Rodriguez-Perez, Noelia, Wirz, Oliver F., Wawrzyniak, Marcin, Pugin, Benoit, Nehrbass, Dirk, Jutel, Marek, Smolinska, Sylwia, Konieczna, Patrycja, Bieli, Christian, Loeliger, Susanne, Waser, Marco, Pershagen, Göran, Riedler, Josef, Depner, Martin, Schaub, Bianca, Genuneit, Jon, Renz, Harald, Pekkanen, Juha, Karvonen, Anne M., Dalphin, Jean-Charles, van Hage, Marianne, Doekes, Gert, Akdis, Mübeccel, Braun-Fahrländer, Charlotte, Akdis, Cezmi A., von Mutius, Erika, O’Mahony, Liam, and Lauener, Roger P.

Published
2018
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35. Association Between Short-term Exposure to Ultrafine Particles and Mortality in Eight European Urban Areas

Author

UF&HEALTH Study Group, Stafoggia, Massimo, Schneider, Alexandra, Cyrys, Josef, Samoli, Evangelia, Andersen, Zorana Jovanovic, Bedada, Getahun Bero, Bellander, Tom, Cattani, Giorgio, Eleftheriadis, Konstantinos, Faustini, Annunziata, Hoffmann, Barbara, Jacquemin, Bénédicte, Katsouyanni, Klea, Massling, Andreas, Pekkanen, Juha, Perez, Noemi, Peters, Annette, Quass, Ulrich, Yli-Tuomi, Tarja, and Forastiere, Francesco

Published
2017

37. Asthmatic farm children show increased CD3+ CD8low T-cells compared to non-asthmatic farm children

Author

Twardziok, Monika, Schröder, Paul C., Krusche, Johanna, Casaca, Vera I., Illi, Sabina, Böck, Andreas, Loss, Georg J., Kabesch, Michael, Toncheva, Antoaneta A., Roduit, Caroline, Depner, Martin, Genuneit, Jon, Renz, Harald, Roponen, Marjut, Weber, Juliane, Braun-Fahrländer, Charlotte, Riedler, Josef, Lauener, Roger, Vuitton, Dominique Angèle, Dalphin, Jean-Charles, Pekkanen, Juha, von Mutius, Erika, Schaub, Bianca, Hyvärinen, Anne, Karvonen, Anne M., Kirjavainen, Pirkka V., Remes, Sami, Kaulek, Vincent, Dalphin, Marie-Laure, Ege, Markus, Pfefferle, Petra I., and Doekes, Gert

Published
2017
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38. Latent class analysis reveals clinically relevant atopy phenotypes in 2 birth cohorts

Author

Bauer, Carl Peter, Forster, Johannes, Zepp, Fred, Wahn, Volker, Schuster, Antje, Bergmann, Renate L., Bergmann, Karl E., Reich, Andreas, Grabenhenrich, Linus, Schaub, Bianca, Loss, Georg J., Renz, Harald, Kabesch, Michael, Roponen, Marjut, Hyvärinen, Anne, Tiittanen, Pekka, Remes, Sami, Braun-Fahrländer, Charlotte, Frei, Remo, Kaulek, Vincent, Dalphin, Marie-Laure, Doekes, Gert, Blümer, Nicole, Frey, Urs, Hose, Alexander J., Depner, Martin, Illi, Sabina, Lau, Susanne, Keil, Thomas, Wahn, Ulrich, Fuchs, Oliver, Pfefferle, Petra Ina, Schmaußer-Hechfellner, Elisabeth, Genuneit, Jon, Lauener, Roger, Karvonen, Anne M., Roduit, Caroline, Dalphin, Jean-Charles, Riedler, Josef, Pekkanen, Juha, von Mutius, Erika, and Ege, Markus J.

Published
2017
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40. Renal Effects of Uranium in Drinking Water

Author

Kurttio, Päivi, Auvinen, Anssi, Salonen, Laina, Saha, Heikki, Pekkanen, Juha, Mäkeläinen, Ilona, Väisänen, Sari B., Penttilä, Ilkka M., and Komulainen, Hannu

Published
2002

48. Early‐life environment and the risk of eczema at 2 years—Meta‐analyses of six Finnish birth cohorts

Author

Lukkarinen, Minna, primary, Kirjavainen, Pirkka V., additional, Backman, Katri, additional, Gonzales‐Inca, Carlos, additional, Hickman, Brandon, additional, Kallio, Sampo, additional, Karlsson, Hasse, additional, Karlsson, Linnea, additional, Keski‐Nisula, Leea, additional, Korhonen, Laura S., additional, Korpela, Katri, additional, Kuitunen, Mikael, additional, Kukkonen, Anna Kaarina, additional, Käyhkö, Niina, additional, Lagström, Hanna, additional, Lukkarinen, Heikki, additional, Peltola, Ville, additional, Pentti, Jaana, additional, Salonen, Anne, additional, Savilahti, Erkki, additional, Tuoresmäki, Pauli, additional, Täubel, Martin, additional, Vahtera, Jussi, additional, de Vos, Willem M., additional, Pekkanen, Juha, additional, and Karvonen, Anne M., additional

Published
2023
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49. ω-3 fatty acids contribute to the asthma-protective effect of unprocessed cow's milk

Author

Karvonen, A., Tiittanen, P., Dalphin, M.-L., Schaub, B., Depner, M., Illi, S., Kabesch, M., Brick, Tabea, Schober, Yvonne, Böcking, Christian, Pekkanen, Juha, Genuneit, Jon, Loss, Georg, Dalphin, Jean-Charles, Riedler, Josef, Lauener, Roger, Nockher, Wolfgang Andreas, Renz, Harald, Vaarala, Outi, Braun-Fahrländer, Charlotte, von Mutius, Erika, Ege, Markus Johannes, and Pfefferle, Petra Ina

Published
2016
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50. Author response to Dr Wise's letter

Author

Casas, Lidia, Espinosa, Aina, Borràs-Santos, Alícia, Jacobs, José, Krop, Esmeralda, Heederik, Dick, Nemery, Benoit, Pekkanen, Juha, Hyvärinen, Anne, Täubel, Martin, and Zock, Jan-Paul

Published
2016

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