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Patients with cutaneous leishmaniasis (CL) due toLeishmania braziliensisinfection have an exacerbated inflammatory response associated with tissue damage and ulcer development. An increase in the rate of patients who fail therapy with pentavalent antimony has been documented. An adjuvant therapy with an anti-inflammatory drug with the potential ofLeishmaniakilling would benefit CL patients. The aim of the present study was to investigate the contribution of peroxisome proliferator-activated receptor-γ (PPAR-γ) activation by pioglitazone in the regulation of the inflammatory response andL. braziliensiskilling by monocytes. Pioglitazone is an oral drug used in the treatment of diabetes, and its main mechanism of action is through the activation of PPAR-γ, which is expressed in many cell types of the immune response. We found that activation of PPAR-γ by pioglitazone decreases the inflammatory response in CL patients without affectingL. braziliensiskilling by monocytes. Our data suggest that pioglitazone may serve as an adjunctive treatment for CL caused byL. braziliensis.

Submitted by Helena Fortuna (hfortuna@ubi.pt) on 2015-03-10T12:13:38Z No. of bitstreams: 9 Dissertação Fábio Peixoto.pdf: 8469216 bytes, checksum: a62e1938702441dbf49c76d03a3248b6 (MD5) 1.pdf: 95156 bytes, checksum: 501a275d73c619f73900b2c8d2c8dc4a (MD5) 2.pdf: 129467 bytes, checksum: e57855e828135011e123f5df29969684 (MD5) 3.pdf: 1079434 bytes, checksum: 0b4732e53ea4eb25aa97b30c48d8199c (MD5) 4.pdf: 558355 bytes, checksum: 947dd689ec0acd6417f975e504ca3bee (MD5) 5.pdf: 4949967 bytes, checksum: fc02a84112b6d0b2a7e961e0b8caef73 (MD5) 6.pdf: 405441 bytes, checksum: 75f6fe2f09e86c4f3a06b85fd093469c (MD5) 7.pdf: 456739 bytes, checksum: 239563201229343f60138107e889e0bd (MD5) 8.pdf: 154446 bytes, checksum: 5dc4142b3e73bb9beabee94ce5000c55 (MD5) Made available in DSpace on 2015-03-10T12:13:38Z (GMT). No. of bitstreams: 9 Dissertação Fábio Peixoto.pdf: 8469216 bytes, checksum: a62e1938702441dbf49c76d03a3248b6 (MD5) 1.pdf: 95156 bytes, checksum: 501a275d73c619f73900b2c8d2c8dc4a (MD5) 2.pdf: 129467 bytes, checksum: e57855e828135011e123f5df29969684 (MD5) 3.pdf: 1079434 bytes, checksum: 0b4732e53ea4eb25aa97b30c48d8199c (MD5) 4.pdf: 558355 bytes, checksum: 947dd689ec0acd6417f975e504ca3bee (MD5) 5.pdf: 4949967 bytes, checksum: fc02a84112b6d0b2a7e961e0b8caef73 (MD5) 6.pdf: 405441 bytes, checksum: 75f6fe2f09e86c4f3a06b85fd093469c (MD5) 7.pdf: 456739 bytes, checksum: 239563201229343f60138107e889e0bd (MD5) 8.pdf: 154446 bytes, checksum: 5dc4142b3e73bb9beabee94ce5000c55 (MD5) Previous issue date: 2013

Submitted by Deise Lorena Araújo (deiselorena@uepb.edu.br) on 2016-09-02T20:02:36Z No. of bitstreams: 1 PDF - Fábio Rolim Peixoto.pdf: 1353557 bytes, checksum: 3a4ded5d1a973bdb12b81b1831f4e112 (MD5) Approved for entry into archive by Irenilda Medeiros (nildamedeiros@uepb.edu.br) on 2016-09-16T12:53:01Z (GMT) No. of bitstreams: 1 PDF - Fábio Rolim Peixoto.pdf: 1353557 bytes, checksum: 3a4ded5d1a973bdb12b81b1831f4e112 (MD5) Made available in DSpace on 2016-09-16T12:53:01Z (GMT). No. of bitstreams: 1 PDF - Fábio Rolim Peixoto.pdf: 1353557 bytes, checksum: 3a4ded5d1a973bdb12b81b1831f4e112 (MD5) Previous issue date: 2009-08-25 Universidade Estadual da Paraíba In this dissertation, we intend to accomplish the critical analysis of the romance The Hours (The Hours), written by the North American Michael Cunningham, in 1999, as well as of the adaptation of this work for the movies: The Hours, american film driven by Stephen Daldry, in 2002. The work of Cunningham narrates one day in the three women's life that they live in time and different space but they have your linked lives by the romance Mrs. Dalloway, of Virginia Woolf. In the development of this research, we located the present intertextuality in the works of Cunningham and of V. Woolf, showing as this dialogue is introduced to the reader. For the accomplishment of this project, we looked for back-up in the theory of the enunciation, proposed by Mikhail Bakhtin; as well as we fell back upon the parody concepts and paraphrase postulated by Domício Proença Filho, Affonso Romano de Sant´Anna, Linda Hutcheon, Leyla Perrone-Moisés, Julia Kristeva, Sandra Nitrini and Graham Allen. In what it concerns the analysis of the film, we made use of concepts of the movie theories (Bazin, Metz, Agel, Brito, among other) and a comparison between the romance and the film, in the intention of accomplishing aesthetic approaches and semiotics between the literature and the movies. Nesta pesquisa, propomo-nos a realizar a análise crítica do romance As Horas (The Hours), escrito pelo norte-americano Michael Cunningham, em 1999, como também da adaptação desta obra para o cinema: As Horas, filme americano dirigido por Stephen Daldry, em 2002. A obra de Cunningham narra um dia na vida de três mulheres que vivem em tempo e espaço distintos mas têm suas vidas ligadas pelo romance Mrs. Dalloway, de Virginia Woolf. No desenvolvimento desta pesquisa, localizamos a intertextualidade presente nas obras de Cunningham e de V. Wololf, mostrando como este diálogo é apresentado ao leitor. Para a realização deste intento, buscamos respaldo na teoria da enunciação, proposta por Mikhail Bakhtin; bem como recorremos aos conceitos de paródia e paráfrase postulados por Domício Proença Filho, Affonso Romano de Sant´Anna, Linda Hutcheon, Leyla Perrone-Moisés, Julia Kristeva, Sandra Nitrini e Graham Allen. No que diz respeito à análise do filme, fizemos uso de conceitos das teorias fílmicas (Bazin, Metz, Agel, Brito, entre outros) e uma comparação entre o romance e o filme, na intenção de realizar aproximações estéticas e semióticas entre a literatura e o cinema.